BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 57114 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Cyclin-dependent kinase 7 Homo sapiens 2900 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57115 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Cyclin-dependent kinase 7 Homo sapiens 4.5 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57116 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Cyclin-dependent kinase 7 Homo sapiens 6200 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57117 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 31 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57118 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Cyclin-dependent kinase 7 Homo sapiens 2600 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57119 CN1CCC([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12?,17-/m1/s1 BIIVYFLTOXDAOV-RGUGMKFQSA-N 31099 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methyl-4-piperidinyl]-1-benzopyran-4-one::2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methyl-4-piperidyl]chromone::2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one::2-(2-chlorophenyl)-8-[(3S)-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one::CHEMBL45741::Flavopiridol::cid_24867231 Cyclin-dependent kinase 7 Homo sapiens 23 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31099&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3BLR,1C8K,1E1Y 24867231 252615340 CHEMBL45741 ZINC29416077 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57120 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Cyclin-dependent kinase 7 Homo sapiens 760 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57121 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 1800 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57122 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Cyclin-dependent kinase 7 Homo sapiens 930 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57123 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Cyclin-dependent kinase 7 Homo sapiens 140 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57124 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Cyclin-dependent kinase 7 Homo sapiens 45 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 57125 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Cyclin-dependent kinase 7 Homo sapiens 330 7.4 23.00 C PubChem 10.7270/Q2NC5ZHH aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80548 [O-][N+](=O)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1 InChI=1S/C19H13N3O2/c23-22(24)14-11-9-13(10-12-14)20-19-15-5-1-3-7-17(15)21-18-8-4-2-6-16(18)19/h1-12H,(H,20,21) PAOOQRRWBZDBPN-UHFFFAOYSA-N 32344 MLS000723809::N-(4-nitrophenyl)-9-acridinamine::N-(4-nitrophenyl)acridin-9-amine::SMR000305404::acridin-9-yl-(4-nitrophenyl)amine::cid_47484 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32344&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 47484 252615779 ZINC04015369 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80549 Brc1ccc(cc1)C(=O)NNC1=Nc2cccc3cccc1c23 InChI=1S/C18H12BrN3O/c19-13-9-7-12(8-10-13)18(23)22-21-17-14-5-1-3-11-4-2-6-15(20-17)16(11)14/h1-10H,(H,20,21)(H,22,23) YEGFDPRPLRNQKO-UHFFFAOYSA-N 32345 MLS000391610::N'-(2-benzo[cd]indolyl)-4-bromobenzohydrazide::N'-benzo[cd]indol-2-yl-4-bromanyl-benzohydrazide::N'-benzo[cd]indol-2-yl-4-bromo-benzohydrazide::N'-benzo[cd]indol-2-yl-4-bromobenzohydrazide::SMR000260645::cid_5044744 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32345&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 5044744 252615780 ZINC04979942 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80550 COC(=O)c1c(NC(=O)C2C3CCC(C3)C2C(O)=O)sc2CCCCCc12 InChI=1S/C20H25NO5S/c1-26-20(25)16-12-5-3-2-4-6-13(12)27-18(16)21-17(22)14-10-7-8-11(9-10)15(14)19(23)24/h10-11,14-15H,2-9H2,1H3,(H,21,22)(H,23,24) SRWNKGYXOWZYBF-UHFFFAOYSA-N 32346 2-[(3-methoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)carbamoyl]bicyclo[2.2.1]heptane-3-carboxylic acid::2-[[(3-methoxycarbonyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)amino]-oxomethyl]-3-bicyclo[2.2.1]heptanecarboxylic acid::3-({[3-(methoxycarbonyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid::3-[(3-carbomethoxy-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)carbamoyl]norbornane-2-carboxylic acid::MLS000673690::SMR000298221::cid_2887468 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32346&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2887468 252615781 ZINC04614560 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80551 CSc1ccccc1C(=O)NCc1ccc(F)cc1 InChI=1S/C15H14FNOS/c1-19-14-5-3-2-4-13(14)15(18)17-10-11-6-8-12(16)9-7-11/h2-9H,10H2,1H3,(H,17,18) DPRSNEFBULLPSI-UHFFFAOYSA-N 32347 MLS000674332::N-(4-fluorobenzyl)-2-(methylthio)benzamide::N-[(4-fluorophenyl)methyl]-2-(methylthio)benzamide::N-[(4-fluorophenyl)methyl]-2-methylsulfanyl-benzamide::N-[(4-fluorophenyl)methyl]-2-methylsulfanylbenzamide::SMR000297279::cid_2592173 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32347&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2592173 252615782 ZINC03474051 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80552 CC1Cc2ccccc2N1c1ncnc(N)c1[N+]([O-])=O InChI=1S/C13H13N5O2/c1-8-6-9-4-2-3-5-10(9)17(8)13-11(18(19)20)12(14)15-7-16-13/h2-5,7-8H,6H2,1H3,(H2,14,15,16) IQECUWFFIFFPBO-UHFFFAOYSA-N 32348 6-(2-methyl-2,3-dihydro-1H-indol-1-yl)-5-nitro-4-pyrimidinamine::6-(2-methyl-2,3-dihydroindol-1-yl)-5-nitro-4-pyrimidinamine::6-(2-methyl-2,3-dihydroindol-1-yl)-5-nitro-pyrimidin-4-amine::6-(2-methyl-2,3-dihydroindol-1-yl)-5-nitropyrimidin-4-amine::MLS000665974::SMR000294670::[6-(2-methylindolin-1-yl)-5-nitro-pyrimidin-4-yl]amine::cid_2958734 Cyclin-dependent kinase 7 Homo sapiens 8222.176091 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32348&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2958734 252615783 ZINC04059602 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80553 Cc1cc(NC(=O)CCC(=O)N(Cc2ccco2)C(C(=O)NCC2CCCO2)c2ccncc2)no1 InChI=1S/C25H29N5O6/c1-17-14-21(29-36-17)28-22(31)6-7-23(32)30(16-20-5-3-13-35-20)24(18-8-10-26-11-9-18)25(33)27-15-19-4-2-12-34-19/h3,5,8-11,13-14,19,24H,2,4,6-7,12,15-16H2,1H3,(H,27,33)(H,28,29,31) QQQMLAFGEUIECA-UHFFFAOYSA-N 32349 MLS000688854::N'-(2-furanylmethyl)-N-(5-methyl-3-isoxazolyl)-N'-[2-oxo-2-(2-oxolanylmethylamino)-1-pyridin-4-ylethyl]butanediamide::N'-(2-furfuryl)-N'-[2-keto-1-(4-pyridyl)-2-(tetrahydrofurfurylamino)ethyl]-N-(5-methylisoxazol-3-yl)succinamide::N'-(furan-2-ylmethyl)-N-(5-methyl-1,2-oxazol-3-yl)-N'-[2-oxidanylidene-2-(oxolan-2-ylmethylamino)-1-pyridin-4-yl-ethyl]butanediamide::N'-(furan-2-ylmethyl)-N-(5-methyl-1,2-oxazol-3-yl)-N'-[2-oxo-2-(oxolan-2-ylmethylamino)-1-pyridin-4-ylethyl]butanediamide::SMR000285740::cid_3210804 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32349&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3210804 252615784 ZINC13150871 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80554 O=C(Nc1ccccc1C(=O)N1CCCC1)C1COc2ccccc2O1 InChI=1S/C20H20N2O4/c23-19(18-13-25-16-9-3-4-10-17(16)26-18)21-15-8-2-1-7-14(15)20(24)22-11-5-6-12-22/h1-4,7-10,18H,5-6,11-13H2,(H,21,23) SAPPCAIOKBTHDY-UHFFFAOYSA-N 32350 MLS000708313::N-(2-pyrrolidin-1-ylcarbonylphenyl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide::N-[2-(pyrrolidine-1-carbonyl)phenyl]-2,3-dihydro-1,4-benzodioxin-3-carboxamide::N-[2-(pyrrolidine-1-carbonyl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide::N-[2-[oxo(1-pyrrolidinyl)methyl]phenyl]-2,3-dihydro-1,4-benzodioxin-3-carboxamide::SMR000287780::cid_3152117 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32350&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3152117 252615785 ZINC00793316 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80555 O=C(CSc1ccc2nnc(-c3cccnc3)n2n1)c1ccccc1 InChI=1S/C18H13N5OS/c24-15(13-5-2-1-3-6-13)12-25-17-9-8-16-20-21-18(23(16)22-17)14-7-4-10-19-11-14/h1-11H,12H2 GGYXJCAZPGQJQS-UHFFFAOYSA-N 32351 1-phenyl-2-[(3-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]ethanone::1-phenyl-2-[[3-(3-pyridinyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio]ethanone::1-phenyl-2-[[3-(3-pyridyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio]ethanone::MLS000624306::SMR000323618::cid_7190795 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32351&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 7190795 252615786 ZINC04327927 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80556 CCOC(=O)c1sc(=NC(=O)CCS(=O)(=O)c2ccccc2)n(C)c1C InChI=1S/C17H20N2O5S2/c1-4-24-16(21)15-12(2)19(3)17(25-15)18-14(20)10-11-26(22,23)13-8-6-5-7-9-13/h5-9H,4,10-11H2,1-3H3 LACDMQVFMWOXPA-UHFFFAOYSA-N 32352 2-(3-besylpropanoylimino)-3,4-dimethyl-4-thiazoline-5-carboxylic acid ethyl ester::2-[3-(benzenesulfonyl)-1-oxopropyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester::MLS000624279::SMR000323584::cid_7243149::ethyl 2-[3-(benzenesulfonyl)propanoylimino]-3,4-dimethyl-1,3-thiazole-5-carboxylate::ethyl 3,4-dimethyl-2-[3-(phenylsulfonyl)propanoylimino]-1,3-thiazole-5-carboxylate Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32352&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 7243149 252615787 ZINC13116682 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80557 Clc1ccc(Cl)c(c1)N1CSCC1=O InChI=1S/C9H7Cl2NOS/c10-6-1-2-7(11)8(3-6)12-5-14-4-9(12)13/h1-3H,4-5H2 HRJXNWDAAXUHSF-UHFFFAOYSA-N 32353 3-(2,5-dichlorophenyl)-1,3-thiazolan-4-one::3-(2,5-dichlorophenyl)-1,3-thiazolidin-4-one::3-(2,5-dichlorophenyl)-4-thiazolidinone::3-(2,5-dichlorophenyl)thiazolidin-4-one::3-[2,5-bis(chloranyl)phenyl]-1,3-thiazolidin-4-one::MLS000694803::SMR000333127::cid_1478350 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32353&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1478350 252615788 ZINC01390970 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80558 OC(=O)c1cc(c[nH]1)C(=O)C1CCCCC1 InChI=1S/C12H15NO3/c14-11(8-4-2-1-3-5-8)9-6-10(12(15)16)13-7-9/h6-8,13H,1-5H2,(H,15,16) VNNJHOPOSWRBEL-UHFFFAOYSA-N 32354 4-(cyclohexanecarbonyl)-1H-pyrrole-2-carboxylic acid::4-(cyclohexylcarbonyl)-1H-pyrrole-2-carboxylic acid::4-[cyclohexyl(oxo)methyl]-1H-pyrrole-2-carboxylic acid::4-cyclohexylcarbonyl-1H-pyrrole-2-carboxylic acid::MLS000736313::SMR000338263::cid_1482736 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32354&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1482736 252615789 ZINC04014623 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80559 COc1ccc(Cn2c(=O)[nH]c3cc(ccc3c2=O)C(=O)NC2CCCC2)cc1 InChI=1S/C22H23N3O4/c1-29-17-9-6-14(7-10-17)13-25-21(27)18-11-8-15(12-19(18)24-22(25)28)20(26)23-16-4-2-3-5-16/h6-12,16H,2-5,13H2,1H3,(H,23,26)(H,24,28) FDYKOPIMHKFXOO-UHFFFAOYSA-N 32355 MLS000730065::N-cyclopentyl-2,4-diketo-3-p-anisyl-1H-quinazoline-7-carboxamide::N-cyclopentyl-3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide::N-cyclopentyl-3-[(4-methoxyphenyl)methyl]-2,4-bis(oxidanylidene)-1H-quinazoline-7-carboxamide::N-cyclopentyl-3-[(4-methoxyphenyl)methyl]-2,4-dioxo-1H-quinazoline-7-carboxamide::SMR000308342::cid_16195425 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32355&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16195425 252615790 ZINC04791473 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80560 Cc1c(C#N)c(N)nc(Cl)c1C#N InChI=1S/C8H5ClN4/c1-4-5(2-10)7(9)13-8(12)6(4)3-11/h1H3,(H2,12,13) KXEZBQTZEBDTNH-UHFFFAOYSA-N 32356 2-amino-6-chloro-4-methyl-3,5-pyridinedicarbonitrile::2-amino-6-chloro-4-methyl-dinicotinonitrile::2-amino-6-chloro-4-methylpyridine-3,5-dicarbonitrile::2-azanyl-6-chloranyl-4-methyl-pyridine-3,5-dicarbonitrile::MLS000692177::SMR000333852::cid_606000 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32356&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 606000 252615791 ZINC20366540 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80561 COc1ccc(CNC(=O)C2Cc3ccccc3CN2C(=O)c2ccco2)cc1 InChI=1S/C23H22N2O4/c1-28-19-10-8-16(9-11-19)14-24-22(26)20-13-17-5-2-3-6-18(17)15-25(20)23(27)21-7-4-12-29-21/h2-12,20H,13-15H2,1H3,(H,24,26) PRHKODZYMBRWMQ-UHFFFAOYSA-N 32357 2-(2-furoyl)-N-p-anisyl-3,4-dihydro-1H-isoquinoline-3-carboxamide::2-(furan-2-carbonyl)-N-[(4-methoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide::2-(furan-2-ylcarbonyl)-N-[(4-methoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide::2-[2-furanyl(oxo)methyl]-N-[(4-methoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide::MLS000517008::SMR000343177::cid_3999744 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32357&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3999744 252615792 ZINC03364406 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80562 Cn1cccc1C(=O)NC(=O)COC(=O)c1cc(ccc1Cl)S(=O)(=O)N1CCCCC1 InChI=1S/C20H22ClN3O6S/c1-23-9-5-6-17(23)19(26)22-18(25)13-30-20(27)15-12-14(7-8-16(15)21)31(28,29)24-10-3-2-4-11-24/h5-9,12H,2-4,10-11,13H2,1H3,(H,22,25,26) PTPRILYGRSXZTF-UHFFFAOYSA-N 32358 2-chloro-5-(1-piperidinylsulfonyl)benzoic acid [2-[[(1-methyl-2-pyrrolyl)-oxomethyl]amino]-2-oxoethyl] ester::2-chloro-5-piperidinosulfonyl-benzoic acid [2-keto-2-[(1-methylpyrrole-2-carbonyl)amino]ethyl] ester::MLS001002843::SMR000370809::[2-[(1-methylpyrrol-2-yl)carbonylamino]-2-oxidanylidene-ethyl] 2-chloranyl-5-piperidin-1-ylsulfonyl-benzoate::[2-[(1-methylpyrrole-2-carbonyl)amino]-2-oxoethyl] 2-chloro-5-piperidin-1-ylsulfonylbenzoate::cid_2438071 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32358&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2438071 252615793 ZINC03322600 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80563 O=C(CSc1ccncc1)Nc1ccc2ccccc2c1 InChI=1S/C17H14N2OS/c20-17(12-21-16-7-9-18-10-8-16)19-15-6-5-13-3-1-2-4-14(13)11-15/h1-11H,12H2,(H,19,20) KCXWIWRYZDOMKP-UHFFFAOYSA-N 32359 MLS000772778::N-(2-naphthalenyl)-2-(pyridin-4-ylthio)acetamide::N-(2-naphthyl)-2-(4-pyridylthio)acetamide::N-naphthalen-2-yl-2-pyridin-4-ylsulfanyl-ethanamide::N-naphthalen-2-yl-2-pyridin-4-ylsulfanylacetamide::SMR000377376::cid_2103808 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32359&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2103808 252615794 ZINC12514929 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80564 CC(N=Nc1ncc(Cl)cc1Cl)c1ccccn1 InChI=1S/C12H10Cl2N4/c1-8(11-4-2-3-5-15-11)17-18-12-10(14)6-9(13)7-16-12/h2-8H,1H3 ZWQYXLBRFDHHIP-UHFFFAOYSA-N 32360 (3,5-dichloro-2-pyridyl)-[1-(2-pyridyl)ethylideneamino]amine::3,5-bis(chloranyl)-N-(1-pyridin-2-ylethylideneamino)pyridin-2-amine::3,5-dichloro-N-(1-pyridin-2-ylethylideneamino)pyridin-2-amine::3,5-dichloro-N-[1-(2-pyridinyl)ethylideneamino]-2-pyridinamine::MLS000772548::SMR000377273::cid_3351416 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32360&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 91896151 252615795 ZINC13146785 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 80565 CCCc1cc(=O)[nH]c(SCCCCN2C(=O)c3ccccc3C2=O)n1 InChI=1S/C19H21N3O3S/c1-2-7-13-12-16(23)21-19(20-13)26-11-6-5-10-22-17(24)14-8-3-4-9-15(14)18(22)25/h3-4,8-9,12H,2,5-7,10-11H2,1H3,(H,20,21,23) GXOHAZQQMSEHFC-UHFFFAOYSA-N 32361 2-[4-[(4-keto-6-propyl-1H-pyrimidin-2-yl)thio]butyl]isoindoline-1,3-quinone::2-[4-[(4-oxidanylidene-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butyl]isoindole-1,3-dione::2-[4-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]butyl]isoindole-1,3-dione::2-[4-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)thio]butyl]isoindole-1,3-dione::MLS000761528::SMR000371639::cid_2097425 Cyclin-dependent kinase 7 Homo sapiens >100000 PubChem 10.7270/Q2DV1H9K aid1380 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32361&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2097425 252615796 ZINC13598479 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153806 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 8061 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32::4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4::4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine::CDK Inhibitor, 1::[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine Cyclin-dependent kinase 7 Homo sapiens 73 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8061&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1PXO,2WEV 447961 11108815 C06058 ZINC02047389 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153807 CCNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C16H18N6O2S2/c1-3-18-16-20-10(2)14(25-16)13-7-8-19-15(22-13)21-11-5-4-6-12(9-11)26(17,23)24/h4-9H,3H2,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) TWVJVNNYNNBYED-UHFFFAOYSA-N 81429 CDK Inhibitor, 2 Cyclin-dependent kinase 7 Homo sapiens 56 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81429&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11696791 131342003 ZINC38268005 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153808 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C15H16N6O2S2/c1-9-13(24-15(17-2)19-9)12-6-7-18-14(21-12)20-10-4-3-5-11(8-10)25(16,22)23/h3-8H,1-2H3,(H,17,19)(H2,16,22,23)(H,18,20,21) OTPFZAVDWPCJLJ-UHFFFAOYSA-N 81430 CDK Inhibitor, 3 Cyclin-dependent kinase 7 Homo sapiens 25 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81430&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11675224 131342004 ZINC38224817 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153809 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(=O)(=O)NC)n1 InChI=1S/C16H18N6O2S2/c1-10-14(25-16(17-2)20-10)13-7-8-19-15(22-13)21-11-5-4-6-12(9-11)26(23,24)18-3/h4-9,18H,1-3H3,(H,17,20)(H,19,21,22) YKEMTVGDNWRGJT-UHFFFAOYSA-N 81431 CDK Inhibitor, 4 Cyclin-dependent kinase 7 Homo sapiens 107 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81431&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11560195 131342005 ZINC35816054 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153810 CNS(=O)(=O)c1cccc(Nc2nccc(n2)-c2sc(N)nc2C)c1 InChI=1S/C15H16N6O2S2/c1-9-13(24-14(16)19-9)12-6-7-18-15(21-12)20-10-4-3-5-11(8-10)25(22,23)17-2/h3-8,17H,1-2H3,(H2,16,19)(H,18,20,21) MPLSNQAHULTSPR-UHFFFAOYSA-N 81432 CDK Inhibitor, 5 Cyclin-dependent kinase 7 Homo sapiens 127 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81432&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11689352 131342006 ZINC38252668 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153811 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(C)(=O)=O)n1 InChI=1S/C16H17N5O2S2/c1-10-14(24-16(17-2)19-10)13-7-8-18-15(21-13)20-11-5-4-6-12(9-11)25(3,22)23/h4-9H,1-3H3,(H,17,19)(H,18,20,21) BFQBIVCJNIEQPK-UHFFFAOYSA-N 81433 CDK Inhibitor, 6 Cyclin-dependent kinase 7 Homo sapiens 91 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81433&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11595939 131342007 ZINC35900679 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153812 CCNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(C)(=O)=O)n1 InChI=1S/C17H19N5O2S2/c1-4-18-17-20-11(2)15(25-17)14-8-9-19-16(22-14)21-12-6-5-7-13(10-12)26(3,23)24/h5-10H,4H2,1-3H3,(H,18,20)(H,19,21,22) XUKYEEYMPUGKNF-UHFFFAOYSA-N 81434 CDK Inhibitor, 7 Cyclin-dependent kinase 7 Homo sapiens 47 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81434&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11682552 131342008 ZINC38238888 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153813 CCNS(=O)(=O)c1cccc(Nc2nccc(n2)-c2sc(N)nc2C)c1 InChI=1S/C16H18N6O2S2/c1-3-19-26(23,24)12-6-4-5-11(9-12)21-16-18-8-7-13(22-16)14-10(2)20-15(17)25-14/h4-9,19H,3H2,1-2H3,(H2,17,20)(H,18,21,22) WZGHCPBEOCOZJD-UHFFFAOYSA-N 81435 CDK Inhibitor, 8 Cyclin-dependent kinase 7 Homo sapiens 193 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81435&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11661098 131342009 ZINC38209395 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153814 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C20H24N6O3S2/c1-13-4-5-15(12-17(13)31(27,28)26-8-10-29-11-9-26)24-19-22-7-6-16(25-19)18-14(2)23-20(21-3)30-18/h4-7,12H,8-11H2,1-3H3,(H,21,23)(H,22,24,25) NNMRZPOMVQNXMS-UHFFFAOYSA-N 81436 CDK Inhibitor, 9 Cyclin-dependent kinase 7 Homo sapiens 3469 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81436&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11510921 131342010 ZINC43101526 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153815 Cc1nc(N)sc1-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C19H22N6O3S2/c1-12-3-4-14(11-16(12)30(26,27)25-7-9-28-10-8-25)23-19-21-6-5-15(24-19)17-13(2)22-18(20)29-17/h3-6,11H,7-10H2,1-2H3,(H2,20,22)(H,21,23,24) OQWUAZIPUCLTLQ-UHFFFAOYSA-N 81437 CDK Inhibitor, 10 Cyclin-dependent kinase 7 Homo sapiens 304 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81437&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11640878 131342011 ZINC35984693 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153816 COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2sc(=O)n(C)c2C)cc1 InChI=1S/C18H21N5O4S2/c1-12-16(28-18(24)23(12)2)15-8-9-19-17(22-15)21-13-4-6-14(7-5-13)29(25,26)20-10-11-27-3/h4-9,20H,10-11H2,1-3H3,(H,19,21,22) WQZVTNFUNLTGDW-UHFFFAOYSA-N 81438 CDK Inhibitor, 11 Cyclin-dependent kinase 7 Homo sapiens 940 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81438&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CDK 2XMY 11339532 131342012 ZINC58633057 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153817 Cc1c(sc(=O)n1C)-c1ccnc(Nc2cccc(c2)C#N)n1 InChI=1S/C16H13N5OS/c1-10-14(23-16(22)21(10)2)13-6-7-18-15(20-13)19-12-5-3-4-11(8-12)9-17/h3-8H,1-2H3,(H,18,19,20) ITSPBRBMIPVDCF-UHFFFAOYSA-N 81439 CDK Inhibitor, 12 Cyclin-dependent kinase 7 Homo sapiens 6.8 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81439&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11244207 131342013 ZINC70463262 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153818 Cc1c(sc(=O)n1C)-c1ccnc(Nc2ccc(C)c(c2)N(=O)=O)n1 InChI=1S/C16H15N5O3S/c1-9-4-5-11(8-13(9)21(23)24)18-15-17-7-6-12(19-15)14-10(2)20(3)16(22)25-14/h4-8H,1-3H3,(H,17,18,19) DMCVVJAYVRAPRW-UHFFFAOYSA-N 81440 CDK Inhibitor, 13 Cyclin-dependent kinase 7 Homo sapiens 0.56 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81440&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10089699 131342014 C06058 ZINC34190543 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 153819 Cc1c(sc(=O)n1C)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C19H22N6OS/c1-13-17(27-19(26)24(13)2)16-7-8-21-18(23-16)22-14-3-5-15(6-4-14)25-11-9-20-10-12-25/h3-8,20H,9-12H2,1-2H3,(H,21,22,23) CGGMDMYBCWDOLZ-UHFFFAOYSA-N 81441 CDK Inhibitor, 14 Cyclin-dependent kinase 7 Homo sapiens 2.3 Curated from the literature by BindingDB 10.1016/j.chembiol.2010.07.016 10.7270/Q2BV7F3Q 21035734 aid1799550 Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81441&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11257553 131342015 ZINC58650237 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 200915 Oc1ccc2oc3c(CCCNC3=O)c2c1 InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) AACFPJSJOWQNBN-UHFFFAOYSA-N 32334 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofur[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofuro[2,3-c]azepin-1-one::7-oxidanyl-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::MLS000043346::SMR000019965::cid_755673 Cyclin-dependent kinase 7 Homo sapiens 1.53e+4 Curated from the literature by BindingDB 10.1074/jbc.M805358200 10.7270/Q20863WJ 18829454 aid1799807 Sharlow, ER; Giridhar, KV; LaValle, CR; Chen, J; Leimgruber, S; Barrett, R; Bravo-Altamirano, K; Wipf, P; Lazo, JS; Wang, QJ University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32334&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 755673 252615771 ZINC00210586 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 200919 Oc1ccc2oc(=O)c3NCCCc3c2c1 InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-11(8)12(15)16-10/h3-4,6,13-14H,1-2,5H2 VDZXTSOINJESSP-UHFFFAOYSA-N 92601 CID 797718 Cyclin-dependent kinase 7 Homo sapiens 8.4e+3 Curated from the literature by BindingDB 10.1074/jbc.M805358200 10.7270/Q20863WJ 18829454 aid1799807 Sharlow, ER; Giridhar, KV; LaValle, CR; Chen, J; Leimgruber, S; Barrett, R; Bravo-Altamirano, K; Wipf, P; Lazo, JS; Wang, QJ University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92601&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 797718 160845098 ZINC00302630 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 252780 Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15) AYZRKFOEZQBUEA-UHFFFAOYSA-N 12028 4-Arylazo-3,5-diamino-1H-pyrazole 31b::4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::CAN508 Cyclin-dependent kinase 7 Homo sapiens 2.6e+4 Curated from the literature by BindingDB 10.1111/cbdd.12330 10.7270/Q28C9TXB 24803299 aid1800495 Jorda, R; Navratilova, J; Huskova, Z; Schutznerova, E; Cankai, P; Strnad, M; Krystof, V Institute of Experimental Botany ASCR and Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12028&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search F18 3TN8,3TNH,3TNW,2CLX 9859248 46512535 ZINC17782150 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 252785 Nc1n[nH]c(N)c1\N=N\c1ccncc1 InChI=1S/C8H9N7/c9-7-6(8(10)15-14-7)13-12-5-1-3-11-4-2-5/h1-4H,(H5,9,10,14,15)/b13-12+ RZLCSJZALMLKCU-OUKQBFOZSA-N 123786 AAP1742 Cyclin-dependent kinase 7 Homo sapiens 1.488e+4 Curated from the literature by BindingDB 10.1111/cbdd.12330 10.7270/Q28C9TXB 24803299 aid1800495 Jorda, R; Navratilova, J; Huskova, Z; Schutznerova, E; Cankai, P; Strnad, M; Krystof, V Institute of Experimental Botany ASCR and Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123786&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 21955055 225150195 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 254311 CCN1CCN(Cc2ccc(NC(=O)c3cccc(c3)-c3ccc4nc(NC(=O)C5CC5)sc4n3)cc2C(F)(F)F)CC1 InChI=1S/C29H25F3N8OS/c1-17-34-24(16-25(35-17)40-12-10-33-11-13-40)39-28-38-23-9-8-22(37-27(23)42-28)18-4-2-5-19(14-18)26(41)36-21-7-3-6-20(15-21)29(30,31)32/h2-9,14-16,33H,10-13H2,1H3,(H,36,41)(H,34,35,38,39) LQPZDDNAQNTKSD-UHFFFAOYSA-N 124970 US8765747, 2 Cyclin-dependent kinase 7 Homo sapiens 13 US Patent 10.7270/Q2VX0F6R aid1800532 US8765747 Choi, HG; Sim, T; Gray, N; Zhou, W; Chang, JW; Zhang, J; Weisberg, E Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=124970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=124970&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NG7 4AGW 51359962 225151358 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267701 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m0/s1 SCACHXWSWJBIHG-DZGCQCFKSA-N 50358212 CHEMBL1922218::US8846696, (2S3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 500 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358212&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111408 136962236 CHEMBL1922218 ZINC03939648 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267702 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 1300 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267703 CCC(O)[C@@H](CC)Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-8-7-9-21-10-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m1/s1 VFEDEOUBYBLDKN-AAFJCEBUSA-N 50358221 CHEMBL1922120::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 1100 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358221&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111409 136962245 CHEMBL1922120 ZINC13975716 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267704 CCC(O)[C@H](CC)Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-8-7-9-21-10-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m0/s1 VFEDEOUBYBLDKN-VYRBHSGPSA-N 50358235 CHEMBL1922209::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 1500 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358235&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111410 136962259 CHEMBL1922209 ZINC13975717 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267705 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-8-7-9-22-10-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m1/s1 AGGGWZCOULSEER-PYUWXLGESA-N 50358222 CHEMBL1922121::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 2200 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358222&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111411 136962246 CHEMBL1922121 ZINC73166188 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267706 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-8-7-9-22-10-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m0/s1 AGGGWZCOULSEER-ATNAJCNCSA-N 50358236 CHEMBL1922210::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 3500 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358236&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111412 136962260 CHEMBL1922210 ZINC73160288 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267707 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-9-8-10-23-11-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m1/s1 XHPNYYOUZWOWNT-PYUWXLGESA-N 50358223 CHEMBL1922122::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 1600 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358223&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111413 136962247 CHEMBL1922122 ZINC73168664 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267708 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-9-8-10-23-11-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m0/s1 XHPNYYOUZWOWNT-ATNAJCNCSA-N 50358237 CHEMBL1922211::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol Cyclin-dependent kinase 7 Homo sapiens 3500 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358237&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111414 136962261 CHEMBL1922211 ZINC14020367 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267709 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m1/s1 SQUNXPPTEPGMQR-OAHLLOKOSA-N 50358210 CHEMBL1922123::US8846696, (3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 3100 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358210&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11574520 136962234 CHEMBL1922123 ZINC03939653 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 267710 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m0/s1 SQUNXPPTEPGMQR-HNNXBMFYSA-N 50358211 CHEMBL1922212::US8846696, (3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 2500 7.4 US Patent 10.7270/Q2Z31XCT aid1800694 US8846696 Fischer, PM; Jarman, M; McDonald, E; Nutley, B; Raynaud, F; Wilson, S; Workman, P Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358211&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11581762 136962235 CHEMBL1922212 ZINC03939654 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 308354 COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 InChI=1S/C21H24FN3O3/c1-13(26)24-17-5-3-4-15(10-17)21(27)25-20-11-14(8-9-23-20)18-7-6-16(22)12-19(18)28-2/h6-9,11-12,15,17H,3-5,10H2,1-2H3,(H,24,26)(H,23,25,27)/t15-,17+/m0/s1 QNWXRLPZIFMTBK-DOTOQJQBSA-N 164883 US9067888, 33 Cyclin-dependent kinase 7 Homo sapiens >5000 7.5 US Patent 10.7270/Q2CR5S4T aid1801360 US9067888 Zeitlmann, L; Niestroj, A; Heiser, U AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164883&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 53373586 311419854 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 308355 COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1 InChI=1S/C20H22FN3O3/c1-12(25)23-16-5-3-14(9-16)20(26)24-19-10-13(7-8-22-19)17-6-4-15(21)11-18(17)27-2/h4,6-8,10-11,14,16H,3,5,9H2,1-2H3,(H,23,25)(H,22,24,26) FUMJKSZLZJFCAQ-UHFFFAOYSA-N 164884 US9067888, 34 Cyclin-dependent kinase 7 Homo sapiens >5000 7.5 US Patent 10.7270/Q2CR5S4T aid1801360 US9067888 Zeitlmann, L; Niestroj, A; Heiser, U AstraZeneca AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164884&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76029028 311419855 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50167518 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50165528 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Cyclin-dependent kinase 7 Homo sapiens 87 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50187232 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50190380 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-dependent kinase 7 Homo sapiens 45 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50177668 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Cyclin-dependent kinase 7 Homo sapiens 300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50195280 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Cyclin-dependent kinase 7 Homo sapiens 87 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50227560 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Cyclin-dependent kinase 7 Homo sapiens 45 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50227616 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50302539 N#Cc1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C21H19N5O/c22-12-14-1-3-17-19(10-14)24-25-21(17)20-11-16-9-15(2-4-18(16)23-20)13-26-5-7-27-8-6-26/h1-4,9-11,23H,5-8,13H2,(H,24,25) QJRKDESSUVYBDT-UHFFFAOYSA-N 12116 3-(Indol-2-yl)indazole 6::3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carbonitrile Cyclin-dependent kinase 7 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2015.02.004 10.7270/Q26H4K23 25771484 Song, P; Chen, M; Ma, X; Xu, L; Liu, T; Zhou, Y; Hu, Y Zhejiang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12116&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23645998 46512619 ZINC14949226 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50345215 Cc1cc(nc(OC2CCCCC2)n1)-c1cnc(Nc2ccccn2)s1 InChI=1S/C19H21N5OS/c1-13-11-15(23-18(22-13)25-14-7-3-2-4-8-14)16-12-21-19(26-16)24-17-9-5-6-10-20-17/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,21,24) YEZLWBMZTQEIQF-UHFFFAOYSA-N 50186376 CHEMBL427045::N-(5-(2-(cyclohexyloxy)-6-methylpyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.04.048 10.7270/Q2N29WK0 16682184 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186376&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16037674 104070425 CHEMBL427045 ZINC34875205 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50345219 C1CCC(CC1)Oc1nccc(n1)-c1cnc(Nc2ccccn2)s1 InChI=1S/C18H19N5OS/c1-2-6-13(7-3-1)24-17-20-11-9-14(22-17)15-12-21-18(25-15)23-16-8-4-5-10-19-16/h4-5,8-13H,1-3,6-7H2,(H,19,21,23) GNHNRVSQWNAGHC-UHFFFAOYSA-N 50186373 CHEMBL424696::N-(5-(2-(cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine Cyclin-dependent kinase 7 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2006.04.048 10.7270/Q2N29WK0 16682184 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186373&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44413509 104070422 CHEMBL424696 ZINC34804861 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50336852 CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12 InChI=1S/C30H31F3N8O/c1-4-41-28-26(27(34)35-18-36-28)25(38-41)10-8-20-15-21(6-5-19(20)2)29(42)37-23-9-7-22(24(16-23)30(31,32)33)17-40-13-11-39(3)12-14-40/h5-7,9,15-16,18H,4,11-14,17H2,1-3H3,(H,37,42)(H2,34,35,36) BNRXMSGHPVYSDK-UHFFFAOYSA-N 50086441 CHEMBL3426225::US10266537, Compound 3 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00270 10.7270/Q2J38V91 25835317 Zhang, CH; Zheng, MW; Li, YP; Lin, XD; Huang, M; Zhong, L; Li, GB; Zhang, RJ; Lin, WT; Jiao, Y; Wu, XA; Yang, J; Xiang, R; Chen, LJ; Zhao, YL; Cheng, W; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50086441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50086441&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118737057 103985649 CHEMBL3426225 ZINC27650632 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50331856 COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) ZDNURMVOKAERHZ-UHFFFAOYSA-N 50179207 3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine::CHEMBL120077::JNJ-10198409 Cyclin-dependent kinase 7 Homo sapiens 56700 ChEMBL 10.1021/jm050680m 10.7270/Q2W095HW 16366598 Ho, CY; Ludovici, DW; Maharoof, US; Mei, J; Sechler, JL; Tuman, RW; Strobel, ED; Andraka, L; Yen, HK; Leo, G; Li, J; Almond, H; Lu, H; DeVine, A; Tominovich, RM; Baker, J; Emanuel, S; Gruninger, RH; Middleton, SA; Johnson, DL; Galemmo, RA Johnson & Johnson Pharmaceutical Research and Development LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179207&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9797370 104064435 CHEMBL120077 6020 ZINC13677843 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50726790 CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 InChI=1S/C19H18F3N5O3/c1-18(2)11-4-3-10(7-13(11)25-14(28)8-30-18)24-17-26-12-5-6-29-15(12)16(27-17)23-9-19(20,21)22/h3-7H,8-9H2,1-2H3,(H,25,28)(H2,23,24,26,27) IGRYEDIMNMEBBU-UHFFFAOYSA-N 50235816 CHEMBL4069365 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235816&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137634241 384991558 CHEMBL4069365 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50345200 Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 InChI=1S/C19H21N5OS/c1-13-11-21-18(25-14-7-3-2-4-8-14)24-17(13)15-12-22-19(26-15)23-16-9-5-6-10-20-16/h5-6,9-12,14H,2-4,7-8H2,1H3,(H,20,22,23) LZCHLXVPHWVKTF-UHFFFAOYSA-N 50186374 CHEMBL212049::N-(5-(2-(cyclohexyloxy)-5-methylpyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine Cyclin-dependent kinase 7 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2006.04.048 10.7270/Q2N29WK0 16682184 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186374&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44413527 104070423 CHEMBL212049 ZINC34804865 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50345201 CN1CCN(Cc2cnc(Nc3ncc(s3)-c3cc(C)nc(OC4CCCCC4)n3)cn2)CC1 InChI=1S/C24H32N8OS/c1-17-12-20(29-23(28-17)33-19-6-4-3-5-7-19)21-14-27-24(34-21)30-22-15-25-18(13-26-22)16-32-10-8-31(2)9-11-32/h12-15,19H,3-11,16H2,1-2H3,(H,26,27,30) DLIDUXYWQPLFEM-UHFFFAOYSA-N 50186375 CHEMBL210540::N-(5-(2-(cyclohexyloxy)-6-methylpyrimidin-4-yl)thiazol-2-yl)-5-((4-methylpiperazin-1-yl)methyl)pyrazin-2-amine Cyclin-dependent kinase 7 Homo sapiens 530 ChEMBL 10.1016/j.bmcl.2006.04.048 10.7270/Q2N29WK0 16682184 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50186375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50186375&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16037675 104070424 CHEMBL210540 ZINC34804858 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50380305 CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1 InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30) HESLKTSGTIBHJU-UHFFFAOYSA-N 50269948 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one::CHEMBL514554::D3RKN_2::PF-228::US10266549, Example 32::US10774092, Example 32 Cyclin-dependent kinase 7 Homo sapiens 197 ChEMBL 10.1074/jbc.M606695200 10.7270/Q2J67GQH 17395594 Slack-Davis, JK; Martin, KH; Tilghman, RW; Iwanicki, M; Ung, EJ; Autry, C; Luzzio, MJ; Cooper, B; Kath, JC; Roberts, WG; Parsons, JT University of Virginia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269948&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P4N 6YOJ 11612883 104115362 CHEMBL514554 ZINC35636073 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50391820 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 3.2 ChEMBL 10.1016/j.bmcl.2015.05.100 10.7270/Q2736SQ1 26115571 Sánchez-Martínez, C; Gelbert, LM; Lallena, MJ; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408430 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C(O)=O InChI=1S/C16H14ClN5O4S/c1-10-3-4-11(16(23)24)7-13(10)27(25,26)21(2)18-8-12-9-19-22-6-5-14(17)20-15(12)22/h3-9H,1-2H3,(H,23,24)/b18-8+ RBFTYVKFYBZVGB-QGMBQPNBSA-N 50118210 CHEMBL3612497 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118210&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188264 104011547 CHEMBL3612497 ZINC13491035 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408431 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C#N InChI=1S/C16H13ClN6O2S/c1-11-3-4-12(8-18)7-14(11)26(24,25)22(2)19-9-13-10-20-23-6-5-15(17)21-16(13)23/h3-7,9-10H,1-2H3/b19-9+ AYCKASQUVBKOMD-DJKKODMXSA-N 50118212 CHEMBL3612498 Cyclin-dependent kinase 7 Homo sapiens 3590 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118212&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188266 104011549 CHEMBL3612498 ZINC87515504 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408434 CN(\N=C\c1cnn2ccc(C)nc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H16N6O4S/c1-11-4-5-14(22(23)24)8-15(11)27(25,26)20(3)17-9-13-10-18-21-7-6-12(2)19-16(13)21/h4-10H,1-3H3/b17-9+ QZIMFEZMFNJUKH-RQZCQDPDSA-N 50118224 CHEMBL3612503 Cyclin-dependent kinase 7 Homo sapiens 8750 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118224&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188271 104011561 CHEMBL3612503 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408435 COc1ccc(cc1OC)-c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C23H22N6O6S/c1-15-5-7-18(29(30)31)12-22(15)36(32,33)27(2)24-13-17-14-25-28-10-9-19(26-23(17)28)16-6-8-20(34-3)21(11-16)35-4/h5-14H,1-4H3/b24-13+ UCRFEDKYGLHWFM-ZMOGYAJESA-N 50118236 CHEMBL3612504 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118236&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188272 104011573 CHEMBL3612504 ZINC08035172 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408437 CN(\N=C\c1cnn2ccc(nc12)-c1cccnc1)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C20H17N7O4S/c1-14-5-6-17(27(28)29)10-19(14)32(30,31)25(2)22-12-16-13-23-26-9-7-18(24-20(16)26)15-4-3-8-21-11-15/h3-13H,1-2H3/b22-12+ ZRKHDIABAALLSW-WSDLNYQXSA-N 50118241 CHEMBL3612505 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118241&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188273 104011578 CHEMBL3612505 ZINC27325228 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408438 COc1ccc(cn1)-c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2n1 InChI=1S/C21H19N7O5S/c1-14-4-6-17(28(29)30)10-19(14)34(31,32)26(2)23-12-16-13-24-27-9-8-18(25-21(16)27)15-5-7-20(33-3)22-11-15/h4-13H,1-3H3/b23-12+ JWTRWPDHWSAJPG-FSJBWODESA-N 50118259 CHEMBL3612506 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118259&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188274 104011596 CHEMBL3612506 ZINC01494381 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408443 CN(\N=C\c1cnn2ccc(nc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H13N7O4S/c1-11-3-4-14(23(24)25)7-15(11)28(26,27)21(2)18-9-12-10-19-22-6-5-13(8-17)20-16(12)22/h3-7,9-10H,1-2H3/b18-9+ NAYMGHBSMQSCDC-GIJQJNRQSA-N 50118334 CHEMBL3612507 Cyclin-dependent kinase 7 Homo sapiens 1811 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118334&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188275 104011671 CHEMBL3612507 ZINC27330536 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408444 CN(CCc1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)C#N InChI=1S/C17H16ClN5O2S/c1-12-3-4-13(10-19)9-15(12)26(24,25)22(2)7-5-14-11-20-23-8-6-16(18)21-17(14)23/h3-4,6,8-9,11H,5,7H2,1-2H3 LAZZFPCNZBTRIQ-UHFFFAOYSA-N 50118344 CHEMBL3612513 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118344&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188281 104011681 CHEMBL3612513 ZINC13491161 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408447 Cc1ccc(cc1S(=O)(=O)n1cc(cn1)-c1cnn2ccc(Cl)nc12)[N+]([O-])=O InChI=1S/C16H11ClN6O4S/c1-10-2-3-12(23(24)25)6-14(10)28(26,27)22-9-11(7-19-22)13-8-18-21-5-4-15(17)20-16(13)21/h2-9H,1H3 OQOSJDFXPZMLPT-UHFFFAOYSA-N 50118345 CHEMBL3612514 Cyclin-dependent kinase 7 Homo sapiens 1680 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118345&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188282 319565714 CHEMBL3612514 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408595 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C15H13ClN6O4S/c1-10-3-4-12(22(23)24)7-13(10)27(25,26)20(2)17-8-11-9-18-21-6-5-14(16)19-15(11)21/h3-9H,1-2H3/b17-8+ QATNWRWOYYFNQO-CAOOACKPSA-N 50118346 CHEMBL3612482 Cyclin-dependent kinase 7 Homo sapiens 841 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118346&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188249 319565715 CHEMBL3612482 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408596 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccccc1 InChI=1S/C14H12ClN5O2S/c1-19(23(21,22)12-5-3-2-4-6-12)16-9-11-10-17-20-8-7-13(15)18-14(11)20/h2-10H,1H3/b16-9+ GGBHZIZDAKPCPO-CXUHLZMHSA-N 50118347 CHEMBL3612483 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118347&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188250 319565716 CHEMBL3612483 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408597 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccccc1C InChI=1S/C15H14ClN5O2S/c1-11-5-3-4-6-13(11)24(22,23)20(2)17-9-12-10-18-21-8-7-14(16)19-15(12)21/h3-10H,1-2H3/b17-9+ MVCPWLSPXUGHMG-RQZCQDPDSA-N 50118350 CHEMBL3612484 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118350&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188251 319565717 CHEMBL3612484 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408598 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(c1)[N+]([O-])=O InChI=1S/C14H11ClN6O4S/c1-19(26(24,25)12-4-2-3-11(7-12)21(22)23)16-8-10-9-17-20-6-5-13(15)18-14(10)20/h2-9H,1H3/b16-8+ MMJRDYPVGDJVNB-LZYBPNLTSA-N 50118352 CHEMBL3612485 Cyclin-dependent kinase 7 Homo sapiens 9244 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118352&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188252 319565718 CHEMBL3612485 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408599 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(C)c1 InChI=1S/C15H14ClN5O2S/c1-11-4-3-5-13(8-11)24(22,23)20(2)17-9-12-10-18-21-7-6-14(16)19-15(12)21/h3-10H,1-2H3/b17-9+ OPFFMYGRWXUDIA-RQZCQDPDSA-N 50118353 CHEMBL3612486 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118353&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188253 319565719 CHEMBL3612486 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408600 COc1cccc(c1)S(=O)(=O)N(C)\N=C\c1cnn2ccc(Cl)nc12 InChI=1S/C15H14ClN5O3S/c1-20(25(22,23)13-5-3-4-12(8-13)24-2)17-9-11-10-18-21-7-6-14(16)19-15(11)21/h3-10H,1-2H3/b17-9+ ZNQHETPKCVAICQ-RQZCQDPDSA-N 50118354 CHEMBL3612487 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118354&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188254 319565720 CHEMBL3612487 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408601 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(OC(F)(F)F)c1 InChI=1S/C15H11ClF3N5O3S/c1-23(20-8-10-9-21-24-6-5-13(16)22-14(10)24)28(25,26)12-4-2-3-11(7-12)27-15(17,18)19/h2-9H,1H3/b20-8+ OYSNJOXPTBUMBO-DNTJNYDQSA-N 50118356 CHEMBL3612488 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118356&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188255 319565721 CHEMBL3612488 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408602 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(c1)C#N InChI=1S/C15H11ClN6O2S/c1-21(25(23,24)13-4-2-3-11(7-13)8-17)18-9-12-10-19-22-6-5-14(16)20-15(12)22/h2-7,9-10H,1H3/b18-9+ SNTZKZOXOUODGP-GIJQJNRQSA-N 50118357 CHEMBL3612489 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118357&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188256 319565722 CHEMBL3612489 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408603 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C14H11ClN6O4S/c1-19(26(24,25)12-4-2-11(3-5-12)21(22)23)16-8-10-9-17-20-7-6-13(15)18-14(10)20/h2-9H,1H3/b16-8+ OXBZVQIFYTWYEI-LZYBPNLTSA-N 50118361 CHEMBL3612491 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118361&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188258 319565724 CHEMBL3612491 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408604 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C14H11ClFN5O2S/c1-20(24(22,23)12-4-2-11(16)3-5-12)17-8-10-9-18-21-7-6-13(15)19-14(10)21/h2-9H,1H3/b17-8+ OPDRBXSFNAPNDV-CAOOACKPSA-N 50118362 CHEMBL3612492 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118362&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188259 319565725 CHEMBL3612492 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408605 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccnc1 InChI=1S/C13H11ClN6O2S/c1-19(23(21,22)11-3-2-5-15-9-11)16-7-10-8-17-20-6-4-12(14)18-13(10)20/h2-9H,1H3/b16-7+ TXBODTAZBTZNAK-FRKPEAEDSA-N 50118364 CHEMBL3612494 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118364&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188261 319565727 CHEMBL3612494 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408606 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1ccc[n+]([O-])c1 InChI=1S/C13H11ClN6O3S/c1-18(24(22,23)11-3-2-5-19(21)9-11)15-7-10-8-16-20-6-4-12(14)17-13(10)20/h2-9H,1H3/b15-7+ MCUOKEDQZHNAMS-VIZOYTHASA-N 50118365 CHEMBL3612495 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118365&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188262 319565728 CHEMBL3612495 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50408607 CN(\N=C\c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc(Br)ccc1C InChI=1S/C15H13BrClN5O2S/c1-10-3-4-12(16)7-13(10)25(23,24)21(2)18-8-11-9-19-22-6-5-14(17)20-15(11)22/h3-9H,1-2H3/b18-8+ GIHANMLHNUCTLJ-QGMBQPNBSA-N 50118366 CHEMBL3612496 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.08.035 10.7270/Q2KK9DM6 26349627 Phillipson, LJ; Segal, DH; Nero, TL; Parker, MW; Wan, SS; de Silva, M; Guthridge, MA; Wei, AH; Burns, CJ The University of Melbourne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118366&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122188263 319565729 CHEMBL3612496 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50422573 CN(C)CCCNC(=O)c1csc2nc(cn12)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 InChI=1S/C25H31N7O3S/c1-25(2,3)20-13-21(30-35-20)29-23(34)27-17-9-7-16(8-10-17)18-14-32-19(15-36-24(32)28-18)22(33)26-11-6-12-31(4)5/h7-10,13-15H,6,11-12H2,1-5H3,(H,26,33)(H2,27,29,30,34) VBYMFAOTZHNONG-UHFFFAOYSA-N 50123803 CHEMBL3623375 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.08.068 10.7270/Q24X59MV 26342867 Lin, XD; Yang, HW; Ma, S; Li, WW; Zhang, CH; Wang, WJ; Xiang, R; Li, LL; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50123803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50123803&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122192466 104016215 CHEMBL3623375 ZINC13589966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50436262 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.1016/j.bmcl.2008.09.099 10.7270/Q2BG2NVC 18926699 Fan, J; Fahr, B; Stockett, D; Chan, E; Cheeti, S; Serafimova, I; Lu, Y; Pham, P; Walker, DH; Hoch, U; Choong, IC Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50436265 C[C@@H]1CNC[C@@H](C1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C18H26N4O2S2/c1-11-5-12(7-19-6-11)16(23)22-17-21-9-15(26-17)25-10-14-20-8-13(24-14)18(2,3)4/h8-9,11-12,19H,5-7,10H2,1-4H3,(H,21,22,23)/t11-,12+/m0/s1 SSMMYRQDZBSVCY-NWDGAFQWSA-N 50246466 (3R,5S)-N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)-5-methylpiperidine-3-carboxamide::CHEMBL452602 Cyclin-dependent kinase 7 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2008.09.099 10.7270/Q2BG2NVC 18926699 Fan, J; Fahr, B; Stockett, D; Chan, E; Cheeti, S; Serafimova, I; Lu, Y; Pham, P; Walker, DH; Hoch, U; Choong, IC Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246466&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25169529 104101892 CHEMBL452602 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50480424 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2016.01.011 10.7270/Q2SQ927C 26851505 Vymetalová, L; Havlícek, L; Å turc, A; Skrášková, Z; Jorda, R; Pospíšil, T; Strnad, M; KryÅ¡tof, V Palack£ University and Institute of Experimental Botany AS CR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50480425 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-dependent kinase 7 Homo sapiens 134 ChEMBL 10.1016/j.ejmech.2016.01.011 10.7270/Q2SQ927C 26851505 Vymetalová, L; Havlícek, L; Å turc, A; Skrášková, Z; Jorda, R; Pospíšil, T; Strnad, M; KryÅ¡tof, V Palack£ University and Institute of Experimental Botany AS CR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50480426 CC(O)CNc1nc(NCc2ccc(cc2)-c2ccccn2)c2[nH]nc(C(C)C)c2n1 InChI=1S/C23H27N7O/c1-14(2)19-20-21(30-29-19)22(28-23(27-20)26-12-15(3)31)25-13-16-7-9-17(10-8-16)18-6-4-5-11-24-18/h4-11,14-15,31H,12-13H2,1-3H3,(H,29,30)(H2,25,26,27,28) BEMMPKXTCFGEAN-UHFFFAOYSA-N 50154932 CHEMBL3774632 Cyclin-dependent kinase 7 Homo sapiens 2780 ChEMBL 10.1016/j.ejmech.2016.01.011 10.7270/Q2SQ927C 26851505 Vymetalová, L; Havlícek, L; Å turc, A; Skrášková, Z; Jorda, R; Pospíšil, T; Strnad, M; KryÅ¡tof, V Palack£ University and Institute of Experimental Botany AS CR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154932&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 127030849 340133502 CHEMBL3774632 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50505005 CC(=O)N1CCC(CC1)n1cc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)cn1 InChI=1S/C21H21ClN8O/c1-14(31)28-8-5-16(6-9-28)30-13-15(10-25-30)26-21-24-11-17(22)20(27-21)18-12-23-19-4-2-3-7-29(18)19/h2-4,7,10-13,16H,5-6,8-9H2,1H3,(H,24,26,27) FBFCEASGGVTKEY-UHFFFAOYSA-N 50184466 CHEMBL3823659 Cyclin-dependent kinase 7 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.6b00203 10.7270/Q2KS6TG9 27078757 Degorce, SL; Boyd, S; Curwen, JO; Ducray, R; Halsall, CT; Jones, CD; Lach, F; Lenz, EM; Pass, M; Pass, S; Trigwell, C AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184466&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 127051599 346550416 CHEMBL3823659 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50505006 C[C@@H](O)C(=O)N1CCC(CC1)n1nc(C)c(Nc2ncc(Cl)c(n2)-c2cnn3ccccc23)c1C InChI=1S/C24H27ClN8O2/c1-14-21(15(2)33(30-14)17-7-10-31(11-8-17)23(35)16(3)34)28-24-26-13-19(25)22(29-24)18-12-27-32-9-5-4-6-20(18)32/h4-6,9,12-13,16-17,34H,7-8,10-11H2,1-3H3,(H,26,28,29)/t16-/m1/s1 PZKWAHCUWGHBLH-MRXNPFEDSA-N 50184461 CHEMBL3823030 Cyclin-dependent kinase 7 Homo sapiens 300 ChEMBL 10.1021/acs.jmedchem.6b00203 10.7270/Q2KS6TG9 27078757 Degorce, SL; Boyd, S; Curwen, JO; Ducray, R; Halsall, CT; Jones, CD; Lach, F; Lenz, EM; Pass, M; Pass, S; Trigwell, C AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184461&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126970673 346550411 CHEMBL3823030 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50506115 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.1016/j.bmcl.2008.09.073 10.7270/Q28P60H0 18842409 Choong, IC; Serafimova, I; Fan, J; Stockett, D; Chan, E; Cheeti, S; Lu, Y; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50506116 CC(C)(C)c1cnc(CSc2cnc(N[C@H]3CC[C@H](N)CC3)s2)o1 InChI=1S/C17H26N4OS2/c1-17(2,3)13-8-19-14(22-13)10-23-15-9-20-16(24-15)21-12-6-4-11(18)5-7-12/h8-9,11-12H,4-7,10,18H2,1-3H3,(H,20,21)/t11-,12- JFSGUSJACVSEKX-HAQNSBGRSA-N 50293174 (trans)-N1-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)cyclohexane-1,4-diamine::CHEMBL496567 Cyclin-dependent kinase 7 Homo sapiens 105 ChEMBL 10.1016/j.bmcl.2008.09.073 10.7270/Q28P60H0 18842409 Choong, IC; Serafimova, I; Fan, J; Stockett, D; Chan, E; Cheeti, S; Lu, Y; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293174&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25195254 104134725 CHEMBL496567 ZINC40424652 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50576464 COc1ccc(cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1 InChI=1S/C22H19F3N4O4/c1-12-16(13(2)33-28-12)10-29-17-5-4-15(7-18(17)32-11-20(29)30)21(31)27-9-14-3-6-19(26-8-14)22(23,24)25/h3-8H,9-11H2,1-2H3,(H,27,31) IZHDJXVLMSZONH-UHFFFAOYSA-N 41575 CHEMBL1094408::US8614220, A85B1C1Z Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41575&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 071 3KB7 24993189 251974447 CHEMBL1094408 ZINC70725351 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50595365 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50597001 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Cyclin-dependent kinase 7 Homo sapiens 330 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50596100 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50596306 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579933 Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23) GPSZYOIFQZPWEJ-UHFFFAOYSA-N 50277583 2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5::4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine::Aminopyrimidine, 9::CHEMBL482967::CYC-116 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277583&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6420138 104120139 CHEMBL482967 ZINC03950132 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579934 Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCN(CC2)S(C)(=O)=O)n1 InChI=1S/C20H24N6O2S2/c1-14-19(29-15(2)22-14)18-8-9-21-20(24-18)23-16-4-6-17(7-5-16)25-10-12-26(13-11-25)30(3,27)28/h4-9H,10-13H2,1-3H3,(H,21,23,24) ZINARMLOUXQARO-UHFFFAOYSA-N 50319626 4-(2,4-Dimethylthiazol-5-yl)-N-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrimidin-2-amine::CHEMBL1083484 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319626&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11744184 104153987 CHEMBL1083484 ZINC36403407 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579935 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1 InChI=1S/C21H24N6OS/c1-14-20(29-15(2)23-14)19-8-9-22-21(25-19)24-17-4-6-18(7-5-17)27-12-10-26(11-13-27)16(3)28/h4-9H,10-13H2,1-3H3,(H,22,24,25) WMIWANZLOJYLPU-UHFFFAOYSA-N 50319627 1-(4-(4-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone::CHEMBL1083786 Cyclin-dependent kinase 7 Homo sapiens 2804 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319627&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10024433 104153988 CHEMBL1083786 ZINC34105115 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579936 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C21H25N7OS/c1-14-19(30-21(22-3)24-14)18-8-9-23-20(26-18)25-16-4-6-17(7-5-16)28-12-10-27(11-13-28)15(2)29/h4-9H,10-13H2,1-3H3,(H,22,24)(H,23,25,26) QLNAEPZXTGNWCX-UHFFFAOYSA-N 50319615 1-(4-(4-(4-(4-Methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone::CHEMBL1083785 Cyclin-dependent kinase 7 Homo sapiens 1080 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319615&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10320107 104153976 CHEMBL1083785 ZINC38513035 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579937 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(N)nc2C)cc1 InChI=1S/C20H23N7OS/c1-13-18(29-19(21)23-13)17-7-8-22-20(25-17)24-15-3-5-16(6-4-15)27-11-9-26(10-12-27)14(2)28/h3-8H,9-12H2,1-2H3,(H2,21,23)(H,22,24,25) ZBYYPNTVDDUJTC-UHFFFAOYSA-N 50319616 1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone::CHEMBL1084969 Cyclin-dependent kinase 7 Homo sapiens 2149 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319616&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46830768 104153977 CHEMBL1084969 ZINC49037499 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579938 CCNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C20H24N6OS/c1-3-21-20-23-14(2)18(28-20)17-8-9-22-19(25-17)24-15-4-6-16(7-5-15)26-10-12-27-13-11-26/h4-9H,3,10-13H2,1-2H3,(H,21,23)(H,22,24,25) KBXAGBWPAVTLBI-UHFFFAOYSA-N 50319617 CHEMBL1084630::N-Ethyl-4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319617&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10340715 104153978 CHEMBL1084630 ZINC03950136 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579939 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C19H22N6OS/c1-13-17(27-19(20-2)22-13)16-7-8-21-18(24-16)23-14-3-5-15(6-4-14)25-9-11-26-12-10-25/h3-8H,9-12H2,1-2H3,(H,20,22)(H,21,23,24) KLIUCXHHFFVGMK-UHFFFAOYSA-N 50319618 CHEMBL1084629::N,4-Dimethyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319618&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10430000 104153979 CHEMBL1084629 ZINC03950135 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579940 Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C19H21N5OS/c1-13-18(26-14(2)21-13)17-7-8-20-19(23-17)22-15-3-5-16(6-4-15)24-9-11-25-12-10-24/h3-8H,9-12H2,1-2H3,(H,20,22,23) WIFHQQKDNLBDGL-UHFFFAOYSA-N 50319619 4-(2,4-Dimethylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine::Aminopyrimidine, 5::CHEMBL1085626 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319619&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10248401 104153980 CHEMBL1085626 ZINC38423616 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579941 CCNc1nc(C)c(s1)-c1ccnc(Nc2ccc(CNC(C)=O)cc2)n1 InChI=1S/C19H22N6OS/c1-4-20-19-23-12(2)17(27-19)16-9-10-21-18(25-16)24-15-7-5-14(6-8-15)11-22-13(3)26/h5-10H,4,11H2,1-3H3,(H,20,23)(H,22,26)(H,21,24,25) VEJCMMPVTMQFME-UHFFFAOYSA-N 50319620 CHEMBL1084715::N-(4-(4-(2-(Ethylamino)-4-methylthiazol-5-yl)pyrimidin-2-ylamino)benzyl)acetamide Cyclin-dependent kinase 7 Homo sapiens 171 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319620&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11646645 104153981 CHEMBL1084715 ZINC35996783 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579942 CCNc1nc(C)c(s1)-c1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1 InChI=1S/C19H23N5O3S/c1-6-20-19-22-11(2)17(28-19)13-7-8-21-18(24-13)23-12-9-14(25-3)16(27-5)15(10-12)26-4/h7-10H,6H2,1-5H3,(H,20,22)(H,21,23,24) LNGVCHKMQJKHDR-UHFFFAOYSA-N 50319621 CHEMBL1086088::N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine Cyclin-dependent kinase 7 Homo sapiens 1395 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11647020 104153982 CHEMBL1086088 ZINC35997162 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579943 CNc1nc(C)c(s1)-c1ccnc(Nc2cc(OC)c(OC)c(OC)c2)n1 InChI=1S/C18H21N5O3S/c1-10-16(27-18(19-2)21-10)12-6-7-20-17(23-12)22-11-8-13(24-3)15(26-5)14(9-11)25-4/h6-9H,1-5H3,(H,19,21)(H,20,22,23) OTACRQCAOBRLAZ-UHFFFAOYSA-N 50319622 CHEMBL1083152::N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yl)thiazol-2-amine Cyclin-dependent kinase 7 Homo sapiens 370 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319622&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11718021 104153983 CHEMBL1083152 ZINC34641505 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579944 COc1cc(Nc2nccc(n2)-c2sc(C)nc2C)cc(OC)c1OC InChI=1S/C18H20N4O3S/c1-10-17(26-11(2)20-10)13-6-7-19-18(22-13)21-12-8-14(23-3)16(25-5)15(9-12)24-4/h6-9H,1-5H3,(H,19,21,22) WOHBHEXSHHPQIV-UHFFFAOYSA-N 50319623 4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine::CHEMBL1083151 Cyclin-dependent kinase 7 Homo sapiens 243 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319623&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11632150 104153984 CHEMBL1083151 ZINC35967092 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579945 Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(N)cc2)n1 InChI=1S/C15H15N5S/c1-9-14(21-10(2)18-9)13-7-8-17-15(20-13)19-12-5-3-11(16)4-6-12/h3-8H,16H2,1-2H3,(H,17,19,20) DGGKOQYFPRMYAH-UHFFFAOYSA-N 50319624 Aminopyrimidine, 4::CHEMBL1084454::N1-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl)benzene-1,4-diamine Cyclin-dependent kinase 7 Homo sapiens 2556 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319624&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46830767 104153985 CHEMBL1084454 ZINC49048774 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579946 CNc1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1 InChI=1S/C16H17N5S/c1-10-15(22-11(2)19-10)14-8-9-18-16(21-14)20-13-6-4-12(17-3)5-7-13/h4-9,17H,1-3H3,(H,18,20,21) BFNPREZASZQRTJ-UHFFFAOYSA-N 50319625 CHEMBL1083150::N1-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl)-N4-methylbenzene-1,4-diamine Cyclin-dependent kinase 7 Homo sapiens 4240 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319625&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46830766 104153986 CHEMBL1083150 ZINC49034924 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579947 CN(C)c1ccc(Nc2nccc(n2)-c2sc(C)nc2C)cc1 InChI=1S/C17H19N5S/c1-11-16(23-12(2)19-11)15-9-10-18-17(21-15)20-13-5-7-14(8-6-13)22(3)4/h5-10H,1-4H3,(H,18,20,21) FGGSNQOBRJVAKL-UHFFFAOYSA-N 8066 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37::4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine, 3::4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1-N-dimethylbenzene-1,4-diamine::N-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N,N-dimethylbenzene-1,4-diamine Cyclin-dependent kinase 7 Homo sapiens 4012 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8066&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CK8 2C5N,1PXP 447962 11108820 DB07562 ZINC01912557 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50579948 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 50229973 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine::4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine::CHEMBL298445::[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE Cyclin-dependent kinase 7 Homo sapiens 70 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229973&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CK7 2WEV,1PXO,4B9D 447961 104098225 CHEMBL298445 DB02833 ZINC02047389 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50596460 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Cyclin-dependent kinase 7 Homo sapiens 140 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50667166 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50668980 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50669096 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Cyclin-dependent kinase 7 Homo sapiens 3100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50666422 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Cyclin-dependent kinase 7 Homo sapiens 680 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50666610 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Cyclin-dependent kinase 7 Homo sapiens 190 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50666703 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50667991 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670880 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Cyclin-dependent kinase 7 Homo sapiens 0.580000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50676909 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670982 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50672546 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50686756 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50679870 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50684098 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50674229 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Cyclin-dependent kinase 7 Homo sapiens 70 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50681343 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Cyclin-dependent kinase 7 Homo sapiens 7700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50682816 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Cyclin-dependent kinase 7 Homo sapiens 4.6 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50689991 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Cyclin-dependent kinase 7 Homo sapiens 2600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50671274 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50674297 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Cyclin-dependent kinase 7 Homo sapiens 3100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50678603 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Cyclin-dependent kinase 7 Homo sapiens 330 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50682931 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Cyclin-dependent kinase 7 Homo sapiens 5100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50687026 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Cyclin-dependent kinase 7 Homo sapiens 2600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50688638 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50688667 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50684399 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670060 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50683059 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50685865 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50687288 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50691764 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 23 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50673267 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Cyclin-dependent kinase 7 Homo sapiens 1200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50680349 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Cyclin-dependent kinase 7 Homo sapiens 3300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50680370 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Cyclin-dependent kinase 7 Homo sapiens 130 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50688959 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670311 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670330 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50670368 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Cyclin-dependent kinase 7 Homo sapiens 5500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50674720 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Cyclin-dependent kinase 7 Homo sapiens 610 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50680419 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Cyclin-dependent kinase 7 Homo sapiens 140 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50681959 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50683338 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50689123 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Cyclin-dependent kinase 7 Homo sapiens 4100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50671878 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Cyclin-dependent kinase 7 Homo sapiens 7200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50690722 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Cyclin-dependent kinase 7 Homo sapiens 2900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50671978 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50673529 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50677813 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50682146 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Cyclin-dependent kinase 7 Homo sapiens 930 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50686196 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50692102 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50674995 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50684921 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Cyclin-dependent kinase 7 Homo sapiens 120 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50688121 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Cyclin-dependent kinase 7 Homo sapiens 7700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50690964 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Cyclin-dependent kinase 7 Homo sapiens 330 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50683750 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50686526 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Cyclin-dependent kinase 7 Homo sapiens 190 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50694173 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Cyclin-dependent kinase 7 Homo sapiens 3.7 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50693076 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50697371 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50693290 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Cyclin-dependent kinase 7 Homo sapiens 3500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50696088 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50697488 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50696216 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 31 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50697612 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Cyclin-dependent kinase 7 Homo sapiens 1700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50695039 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703970 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 1300 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50695088 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Cyclin-dependent kinase 7 Homo sapiens 6200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50693758 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Cyclin-dependent kinase 7 Homo sapiens 2.8 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50851801 Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) AZTMYWWWILJAKW-UHFFFAOYSA-N 50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757 Cyclin-dependent kinase 7 Homo sapiens >1525 ChEMBL 10.1016/j.bmcl.2007.09.063 10.7270/Q2X067WT 17935989 Tao, ZF; Chen, Z; Bui, MH; Kovar, P; Johnson, E; Bouska, J; Zhang, H; Rosenberg, S; Sowin, T; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224883&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44444843 104096404 CHEMBL248757 ZINC28963230 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50865174 COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) ZDNURMVOKAERHZ-UHFFFAOYSA-N 50179207 3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine::CHEMBL120077::JNJ-10198409 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50179207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50179207&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9797370 104064435 CHEMBL120077 6020 ZINC13677843 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50871023 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1073/pnas.0707498104 10.7270/Q24X58QS 18077425 McDermott, U; Sharma, SV; Dowell, L; Greninger, P; Montagut, C; Lamb, J; Archibald, H; Raudales, R; Tam, A; Lee, D; Rothenberg, SM; Supko, JG; Sordella, R; Ulkus, LE; Iafrate, AJ; Maheswaran, S; Njauw, CN; Tsao, H; Drew, L; Hanke, JH; Ma, XJ; Erlander, MG; Gray, NS; Haber, DA; Settleman, J Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898417 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Cyclin-dependent kinase 7 Homo sapiens 2900 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898418 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898419 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Cyclin-dependent kinase 7 Homo sapiens 4.5 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898420 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Cyclin-dependent kinase 7 Homo sapiens 6200 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898421 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898422 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 31 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898423 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Cyclin-dependent kinase 7 Homo sapiens 2600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898424 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898425 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898426 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898427 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898428 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898429 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898430 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898431 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 23 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898432 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898433 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898434 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898435 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898436 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Cyclin-dependent kinase 7 Homo sapiens 760 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898437 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898438 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898439 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898440 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898441 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898443 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898444 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 1800 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898445 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898446 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898447 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898448 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Cyclin-dependent kinase 7 Homo sapiens 140 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898450 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Cyclin-dependent kinase 7 Homo sapiens 930 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898451 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Cyclin-dependent kinase 7 Homo sapiens 330 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898452 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898453 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50898454 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50917069 O=C1NCCc2[nH]c(cc12)-c1ccncc1 InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) DKXHSOUZPMHNIZ-UHFFFAOYSA-N 27344 2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::JMC502647 Compound 8::Pyrrolopyridinone, 1 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1038/nchembio.90 10.7270/Q2DV1KVK 18469809 Montagnoli, A; Valsasina, B; Croci, V; Menichincheri, M; Rainoldi, S; Marchesi, V; Tibolla, M; Tenca, P; Brotherton, D; Albanese, C; Patton, V; Alzani, R; Ciavolella, A; Sola, F; Molinari, A; Volpi, D; Avanzi, N; Fiorentini, F; Cattoni, M; Healy, S; Ballinari, D; Pesenti, E; Isacchi, A; Moll, J; Bensimon, A; Vanotti, E; Santocanale, C Nerviano Medical Sciences Oncology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27344&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 0SY 4F9B 11715767 57299053 ZINC16052718 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50917094 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 875 ChEMBL 10.1038/nchembio.90 10.7270/Q2DV1KVK 18469809 Montagnoli, A; Valsasina, B; Croci, V; Menichincheri, M; Rainoldi, S; Marchesi, V; Tibolla, M; Tenca, P; Brotherton, D; Albanese, C; Patton, V; Alzani, R; Ciavolella, A; Sola, F; Molinari, A; Volpi, D; Avanzi, N; Fiorentini, F; Cattoni, M; Healy, S; Ballinari, D; Pesenti, E; Isacchi, A; Moll, J; Bensimon, A; Vanotti, E; Santocanale, C Nerviano Medical Sciences Oncology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50910078 Cn1cc(C2=C(C(=O)NC2=O)c2cccc(NCC(O)CO)c2)c2cc(F)ccc12 InChI=1S/C22H20FN3O4/c1-26-10-17(16-8-13(23)5-6-18(16)26)20-19(21(29)25-22(20)30)12-3-2-4-14(7-12)24-9-15(28)11-27/h2-8,10,15,24,27-28H,9,11H2,1H3,(H,25,29,30) RPGZQOOZHIEPJW-UHFFFAOYSA-N 50312990 (R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione::CHEMBL1082152 Cyclin-dependent kinase 7 Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2010.01.038 10.7270/Q2ZK5HNS 20138512 Gong, L; Hirschfeld, D; Tan, YC; Heather Hogg, J; Peltz, G; Avnur, Z; Dunten, P Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312990&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search DFN 1R0E 11560568 104147351 CHEMBL1082152 3502 ZINC12501080 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925903 C1CN(CCO1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)-c2cccnc2)c1 InChI=1S/C22H20N6OS/c1-2-16(12-23-4-1)17-10-18(14-24-13-17)20-15-26-22(30-20)27-21-11-19(3-5-25-21)28-6-8-29-9-7-28/h1-5,10-15H,6-9H2,(H,25,26,27) NWDVUFMFJOBAFA-UHFFFAOYSA-N 50379623 CHEMBL2011344 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379623&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867443 160858706 CHEMBL2011344 ZINC84614485 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925904 FC(F)(F)CNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C20H19F3N6O2S/c21-20(22,23)12-27-18(30)14-7-13(9-24-10-14)16-11-26-19(32-16)28-17-8-15(1-2-25-17)29-3-5-31-6-4-29/h1-2,7-11H,3-6,12H2,(H,27,30)(H,25,26,28) IVARDFDBTMUCOJ-UHFFFAOYSA-N 50379624 CHEMBL2013167 Cyclin-dependent kinase 7 Homo sapiens 705 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379624&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15980107 160858707 CHEMBL2013167 ZINC34840681 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925935 O=C(CN1CCN(CC1)c1ccnc(Nc2ncc(s2)-c2cccnc2)c1)N1CCOCC1 InChI=1S/C23H27N7O2S/c31-22(30-10-12-32-13-11-30)17-28-6-8-29(9-7-28)19-3-5-25-21(14-19)27-23-26-16-20(33-23)18-2-1-4-24-15-18/h1-5,14-16H,6-13,17H2,(H,25,26,27) QCBHCZCWZWNPGE-UHFFFAOYSA-N 50379625 CHEMBL2011328 Cyclin-dependent kinase 7 Homo sapiens 1760 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379625&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 07S 3TKH 56932125 160858708 CHEMBL2011328 ZINC84602340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925936 Cc1ccc(cn1)-c1cnc(Nc2cccc(NCCCN)n2)s1 InChI=1S/C17H20N6S/c1-12-6-7-13(10-20-12)14-11-21-17(24-14)23-16-5-2-4-15(22-16)19-9-3-8-18/h2,4-7,10-11H,3,8-9,18H2,1H3,(H2,19,21,22,23) OZMDYYHDLBNHMW-UHFFFAOYSA-N 50379626 CHEMBL2013059 Cyclin-dependent kinase 7 Homo sapiens 870 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379626&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867482 160858709 CHEMBL2013059 ZINC84604297 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925937 C1CN(CCN1)c1cccc(Nc2ncc(s2)-c2ccccc2)n1 InChI=1S/C18H19N5S/c1-2-5-14(6-3-1)15-13-20-18(24-15)22-16-7-4-8-17(21-16)23-11-9-19-10-12-23/h1-8,13,19H,9-12H2,(H,20,21,22) HJAJKTBYEIGNCK-UHFFFAOYSA-N 50379627 CHEMBL2013060 Cyclin-dependent kinase 7 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379627&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70691636 160858710 CHEMBL2013060 ZINC84596465 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925938 Cc1ccc(cn1)-c1cnc(Nc2cccc(n2)N2CCNCC2)s1 InChI=1S/C18H20N6S/c1-13-5-6-14(11-20-13)15-12-21-18(25-15)23-16-3-2-4-17(22-16)24-9-7-19-8-10-24/h2-6,11-12,19H,7-10H2,1H3,(H,21,22,23) UUKXPTABDYCDDA-UHFFFAOYSA-N 50379621 CHEMBL2013061 Cyclin-dependent kinase 7 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979138 160858704 CHEMBL2013061 ZINC34837443 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925939 Cc1ccc(cn1)-c1cnc(Nc2cc(ccn2)N2CCNCC2)s1 InChI=1S/C18H20N6S/c1-13-2-3-14(11-21-13)16-12-22-18(25-16)23-17-10-15(4-5-20-17)24-8-6-19-7-9-24/h2-5,10-12,19H,6-9H2,1H3,(H,20,22,23) GGKLVRKIZQTCIB-UHFFFAOYSA-N 50379628 CHEMBL2011330 Cyclin-dependent kinase 7 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379628&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16091079 160858711 CHEMBL2011330 ZINC35065554 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925940 C1CN(CCN1)c1ccnc(Nc2ncc(s2)-c2cncnc2)c1 InChI=1S/C16H17N7S/c1-2-20-15(7-13(1)23-5-3-17-4-6-23)22-16-21-10-14(24-16)12-8-18-11-19-9-12/h1-2,7-11,17H,3-6H2,(H,20,21,22) MARUNRKQKNXGKR-UHFFFAOYSA-N 50379629 CHEMBL2013062 Cyclin-dependent kinase 7 Homo sapiens 11000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379629&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979015 160858712 CHEMBL2013062 ZINC34836970 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925941 C1CN(CCN1)c1cccc(Nc2ncc(s2)-c2cncnc2)n1 InChI=1S/C16H17N7S/c1-2-14(21-15(3-1)23-6-4-17-5-7-23)22-16-20-10-13(24-16)12-8-18-11-19-9-12/h1-3,8-11,17H,4-7H2,(H,20,21,22) UOSJYZIEZUKMHD-UHFFFAOYSA-N 50379630 CHEMBL2013063 Cyclin-dependent kinase 7 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379630&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979261 160858713 CHEMBL2013063 ZINC34837786 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925942 Brc1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCNCC2)s1 InChI=1S/C17H17BrN6S/c18-13-7-12(9-20-10-13)15-11-22-17(25-15)23-16-8-14(1-2-21-16)24-5-3-19-4-6-24/h1-2,7-11,19H,3-6H2,(H,21,22,23) WEJMLPGOQFFMGP-UHFFFAOYSA-N 50379631 CHEMBL2013064 Cyclin-dependent kinase 7 Homo sapiens 480 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379631&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979393 160858714 CHEMBL2013064 ZINC34838209 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925943 C1CN(CCN1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)-c2cn[nH]c2)c1 InChI=1S/C20H20N8S/c1-2-23-19(8-17(1)28-5-3-21-4-6-28)27-20-24-13-18(29-20)15-7-14(9-22-10-15)16-11-25-26-12-16/h1-2,7-13,21H,3-6H2,(H,25,26)(H,23,24,27) BQLMSQOLZAQQCV-UHFFFAOYSA-N 50379632 CHEMBL2011349 Cyclin-dependent kinase 7 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379632&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979518 160858715 CHEMBL2011349 ZINC34838678 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925944 C1CN(CCO1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)-c2cncnc2)c1 InChI=1S/C21H19N7OS/c1-2-25-20(8-18(1)28-3-5-29-6-4-28)27-21-26-13-19(30-21)16-7-15(9-22-10-16)17-11-23-14-24-12-17/h1-2,7-14H,3-6H2,(H,25,26,27) CCFFFQSJNBTIIM-UHFFFAOYSA-N 50379633 CHEMBL2011346 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379633&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979397 160858716 CHEMBL2011346 ZINC34838224 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925945 C1CN(CCO1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)-n2ccnn2)c1 InChI=1S/C19H18N8OS/c1-2-21-18(10-15(1)26-5-7-28-8-6-26)24-19-22-13-17(29-19)14-9-16(12-20-11-14)27-4-3-23-25-27/h1-4,9-13H,5-8H2,(H,21,22,24) RKJMNPYRJOACTO-UHFFFAOYSA-N 50379634 CHEMBL2013065 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379634&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979747 160858717 CHEMBL2013065 ZINC34839414 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925946 Cn1cc(cn1)-c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCNCC2)s1 InChI=1S/C21H22N8S/c1-28-14-17(12-26-28)15-8-16(11-23-10-15)19-13-25-21(30-19)27-20-9-18(2-3-24-20)29-6-4-22-5-7-29/h2-3,8-14,22H,4-7H2,1H3,(H,24,25,27) RMPTVZJLQIMWDN-UHFFFAOYSA-N 50379635 CHEMBL2013066 Cyclin-dependent kinase 7 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379635&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979519 160858718 CHEMBL2013066 ZINC34838682 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925947 C1CN(CCN1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)-c2cccnc2)c1 InChI=1S/C22H21N7S/c1-2-16(12-24-4-1)17-10-18(14-25-13-17)20-15-27-22(30-20)28-21-11-19(3-5-26-21)29-8-6-23-7-9-29/h1-5,10-15,23H,6-9H2,(H,26,27,28) OFEVJLYZUAVMGH-UHFFFAOYSA-N 50379636 CHEMBL2013067 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379636&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867516 160858719 CHEMBL2013067 ZINC84614882 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925948 OC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCNCC2)s1 InChI=1S/C18H18N6O2S/c25-17(26)13-7-12(9-20-10-13)15-11-22-18(27-15)23-16-8-14(1-2-21-16)24-5-3-19-4-6-24/h1-2,7-11,19H,3-6H2,(H,25,26)(H,21,22,23) XBOYDJMJOONFFV-UHFFFAOYSA-N 50379637 CHEMBL2013068 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379637&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979633 160858720 CHEMBL2013068 ZINC34839072 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925949 NC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C18H18N6O2S/c19-17(25)13-7-12(9-20-10-13)15-11-22-18(27-15)23-16-8-14(1-2-21-16)24-3-5-26-6-4-24/h1-2,7-11H,3-6H2,(H2,19,25)(H,21,22,23) QIMWDPQUOYIAAE-UHFFFAOYSA-N 50379638 CHEMBL2013069 Cyclin-dependent kinase 7 Homo sapiens >3700 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379638&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979630 160858721 CHEMBL2013069 ZINC34839061 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925950 Cc1ccc(NC(=O)c2cncc(c2)-c2cnc(Nc3cc(ccn3)N3CCOCC3)s2)s1 InChI=1S/C23H22N6O2S2/c1-15-2-3-21(32-15)28-22(30)17-10-16(12-24-13-17)19-14-26-23(33-19)27-20-11-18(4-5-25-20)29-6-8-31-9-7-29/h2-5,10-14H,6-9H2,1H3,(H,28,30)(H,25,26,27) CENRERBBOKRKSW-UHFFFAOYSA-N 50379639 CHEMBL2013158 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379639&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70681104 160858722 CHEMBL2013158 ZINC84604967 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925951 CNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C19H20N6O2S/c1-20-18(26)14-8-13(10-21-11-14)16-12-23-19(28-16)24-17-9-15(2-3-22-17)25-4-6-27-7-5-25/h2-3,8-12H,4-7H2,1H3,(H,20,26)(H,22,23,24) GIAYDDWGZZEJQE-UHFFFAOYSA-N 50379640 CHEMBL2013159 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379640&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15980108 160858723 CHEMBL2013159 ZINC34840683 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925952 NCCNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C20H23N7O2S/c21-2-4-24-19(28)15-9-14(11-22-12-15)17-13-25-20(30-17)26-18-10-16(1-3-23-18)27-5-7-29-8-6-27/h1,3,9-13H,2,4-8,21H2,(H,24,28)(H,23,25,26) TWDABHIMTXVQHI-UHFFFAOYSA-N 50379641 CHEMBL2010809 Cyclin-dependent kinase 7 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379641&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search S25 3TKI 15980109 160858724 CHEMBL2010809 ZINC34840685 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925953 CS(=O)(=O)N1CCN(CC1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)C(=O)NCCN)c1 InChI=1S/C21H26N8O3S2/c1-34(31,32)29-8-6-28(7-9-29)17-2-4-24-19(11-17)27-21-26-14-18(33-21)15-10-16(13-23-12-15)20(30)25-5-3-22/h2,4,10-14H,3,5-9,22H2,1H3,(H,25,30)(H,24,26,27) ACQFRIFMXKIEAE-UHFFFAOYSA-N 50379642 CHEMBL2011352 Cyclin-dependent kinase 7 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379642&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979868 160858725 CHEMBL2011352 ZINC34839914 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925954 CC(=O)N1CCN(CC1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)C(=O)NCCN)c1 InChI=1S/C22H26N8O2S/c1-15(31)29-6-8-30(9-7-29)18-2-4-25-20(11-18)28-22-27-14-19(33-22)16-10-17(13-24-12-16)21(32)26-5-3-23/h2,4,10-14H,3,5-9,23H2,1H3,(H,26,32)(H,25,27,28) LYIJASRYGMSEKR-UHFFFAOYSA-N 50379643 CHEMBL2011353 Cyclin-dependent kinase 7 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379643&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15979751 160858726 CHEMBL2011353 ZINC34839427 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925955 NCCNC(=O)c1cncc(c1)-c1cnc(Nc2cc(Cl)ccn2)s1 InChI=1S/C16H15ClN6OS/c17-12-1-3-20-14(6-12)23-16-22-9-13(25-16)10-5-11(8-19-7-10)15(24)21-4-2-18/h1,3,5-9H,2,4,18H2,(H,21,24)(H,20,22,23) BOAVXSFJTVSKNR-UHFFFAOYSA-N 50379644 CHEMBL2013160 Cyclin-dependent kinase 7 Homo sapiens 940 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379644&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867505 160858727 CHEMBL2013160 ZINC84605314 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925956 NCCNC(=O)c1cncc(c1)-c1cnc(Nc2ncccc2Cl)s1 InChI=1S/C16H15ClN6OS/c17-12-2-1-4-20-14(12)23-16-22-9-13(25-16)10-6-11(8-19-7-10)15(24)21-5-3-18/h1-2,4,6-9H,3,5,18H2,(H,21,24)(H,20,22,23) IFRUMWOKOKWYRB-UHFFFAOYSA-N 50379622 CHEMBL2013161 Cyclin-dependent kinase 7 Homo sapiens 960 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379622&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867490 160858705 CHEMBL2013161 ZINC84605317 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925957 Cc1cccnc1Nc1ncc(s1)-c1cncc(c1)C(=O)NCCN InChI=1S/C17H18N6OS/c1-11-3-2-5-20-15(11)23-17-22-10-14(25-17)12-7-13(9-19-8-12)16(24)21-6-4-18/h2-3,5,7-10H,4,6,18H2,1H3,(H,21,24)(H,20,22,23) CINWVSLBEUYEBF-UHFFFAOYSA-N 50379645 CHEMBL2013162 Cyclin-dependent kinase 7 Homo sapiens 910 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379645&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867446 160858728 CHEMBL2013162 ZINC84605318 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925958 NCCNC(=O)c1cccc(c1)-c1cnc(Nc2cc(ccn2)N2CCC(F)(F)CC2)s1 InChI=1S/C22H24F2N6OS/c23-22(24)5-10-30(11-6-22)17-4-8-26-19(13-17)29-21-28-14-18(32-21)15-2-1-3-16(12-15)20(31)27-9-7-25/h1-4,8,12-14H,5-7,9-11,25H2,(H,27,31)(H,26,28,29) JBQDYFRBEKDLMG-UHFFFAOYSA-N 50379646 CHEMBL2013163 Cyclin-dependent kinase 7 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379646&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15980106 160858729 CHEMBL2013163 ZINC34840680 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925959 NCCCCc1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C21H26N6OS/c22-5-2-1-3-16-11-17(14-23-13-16)19-15-25-21(29-19)26-20-12-18(4-6-24-20)27-7-9-28-10-8-27/h4,6,11-15H,1-3,5,7-10,22H2,(H,24,25,26) FLWOVCZKXXWOJC-UHFFFAOYSA-N 50379647 CHEMBL2013164 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379647&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70685325 160858730 CHEMBL2013164 ZINC84605321 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925960 NCCNC(=O)c1cncc(c1)-c1cnc(Nc2ccccc2Cl)s1 InChI=1S/C17H16ClN5OS/c18-13-3-1-2-4-14(13)23-17-22-10-15(25-17)11-7-12(9-20-8-11)16(24)21-6-5-19/h1-4,7-10H,5-6,19H2,(H,21,24)(H,22,23) DNPCRZZEHRJWOJ-UHFFFAOYSA-N 50379648 CHEMBL2013165 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379648&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57867522 160858731 CHEMBL2013165 ZINC84596842 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925961 OCCNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCOCC2)s1 InChI=1S/C20H22N6O3S/c27-6-3-23-19(28)15-9-14(11-21-12-15)17-13-24-20(30-17)25-18-10-16(1-2-22-18)26-4-7-29-8-5-26/h1-2,9-13,27H,3-8H2,(H,23,28)(H,22,24,25) NAAZQHNSHXOSSF-UHFFFAOYSA-N 50379649 CHEMBL2013166 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379649&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 15980233 160858732 CHEMBL2013166 C04080 ZINC34840929 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925962 CS(=O)(=O)N1CCN(CC1)c1ccnc(Nc2ncc(s2)-c2cncc(c2)C(=O)NCC(F)(F)F)c1 InChI=1S/C21H22F3N7O3S2/c1-36(33,34)31-6-4-30(5-7-31)16-2-3-26-18(9-16)29-20-27-12-17(35-20)14-8-15(11-25-10-14)19(32)28-13-21(22,23)24/h2-3,8-12H,4-7,13H2,1H3,(H,28,32)(H,26,27,29) YZSBBJRRSAKGQY-UHFFFAOYSA-N 50379650 CHEMBL2013168 Cyclin-dependent kinase 7 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379650&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57404485 160858733 CHEMBL2013168 ZINC43151895 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925963 NCNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCC(F)CC2)s1 InChI=1S/C20H22FN7OS/c21-15-2-5-28(6-3-15)16-1-4-24-18(8-16)27-20-25-11-17(30-20)13-7-14(10-23-9-13)19(29)26-12-22/h1,4,7-11,15H,2-3,5-6,12,22H2,(H,26,29)(H,24,25,27) KMVFPKOFKPCJSM-UHFFFAOYSA-N 50379651 CHEMBL2013169 Cyclin-dependent kinase 7 Homo sapiens 350 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379651&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57404486 160858734 CHEMBL2013169 ZINC84615440 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50925964 NCNC(=O)c1cncc(c1)-c1cnc(Nc2cc(ccn2)N2CCC(F)(F)CC2)s1 InChI=1S/C20H21F2N7OS/c21-20(22)2-5-29(6-3-20)15-1-4-25-17(8-15)28-19-26-11-16(31-19)13-7-14(10-24-9-13)18(30)27-12-23/h1,4,7-11H,2-3,5-6,12,23H2,(H,27,30)(H,25,26,28) JCSHLEDYODZCMJ-UHFFFAOYSA-N 50379652 CHEMBL2013170 Cyclin-dependent kinase 7 Homo sapiens 317 ChEMBL 10.1016/j.bmcl.2012.01.120 10.7270/Q23B615X 22365762 Dudkin, VY; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Stirdivant, SM; Drakas, RA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379652&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57404487 160858735 CHEMBL2013170 ZINC84615442 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50969398 Clc1cc(c(Cl)s1)S(=O)(=O)N(C(=O)CBr)c1ccccc1 InChI=1S/C12H8BrCl2NO3S2/c13-7-11(17)16(8-4-2-1-3-5-8)21(18,19)9-6-10(14)20-12(9)15/h1-6H,7H2 XOLGJVQMYMQCNT-UHFFFAOYSA-N 50321461 2-bromo-N-(2,5-dichlorothiophen-3-ylsulfonyl)-N-phenylacetamide::CHEMBL1171238 Cyclin-dependent kinase 7 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2012.09.044 10.7270/Q26H4JJZ 23063403 Rotella, DP Montclair State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321461&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49798556 104142990 CHEMBL1171238 ZINC53229868 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50957679 Nc1nc2c(nccc2[nH]1)-c1ccccn1 InChI=1S/C11H9N5/c12-11-15-8-4-6-14-9(10(8)16-11)7-3-1-2-5-13-7/h1-6H,(H3,12,15,16) JZRNXAPRPJTGOG-UHFFFAOYSA-N 50393109 CHEMBL2153264 Cyclin-dependent kinase 7 Homo sapiens 7500 ChEMBL 10.1021/jm200039m 10.7270/Q2QV3NMT 21413800 Shengule, SR; Loa-Kum-Cheung, WL; Parish, CR; Blairvacq, M; Meijer, L; Nakao, Y; Karuso, P Macquarie University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393109&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 67238213 163342133 CHEMBL2153264 ZINC95575386 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50978414 CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1 InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19) IVYWKCAOPCHVMX-UHFFFAOYSA-N 50401152 CHEMBL2205766 Cyclin-dependent kinase 7 Homo sapiens <10000 ChEMBL 10.1016/j.bmcl.2012.05.090 10.7270/Q2HQ412B 22726925 Sunose, M; Bell, K; Ellard, K; Bergamini, G; Neubauer, G; Werner, T; Ramsden, N Cellzome Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50401152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50401152&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44557921 163350176 CHEMBL2205766 ZINC95562659 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50982410 COC(=O)c1c(Cc2ccc(cc2)C(=O)NCCO)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 InChI=1S/C27H23ClN2O5/c1-35-27(34)24-22(15-17-7-9-18(10-8-17)26(33)29-13-14-31)25(32)21-12-11-19(28)16-23(21)30(24)20-5-3-2-4-6-20/h2-12,16,31H,13-15H2,1H3,(H,29,33) STNCBMGTCZRJPA-UHFFFAOYSA-N 50392982 CHEMBL2152382 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.10.066 10.7270/Q27S7PZ6 23142618 Gong, L; Tan, YC; Boice, G; Abbot, S; McCaleb, K; Iyer, P; Zuo, F; Dal Porto, J; Wong, B; Jin, S; Chang, A; Tran, P; Hsieh, G; Niu, L; Shao, A; Reuter, D; Lukacs, CM; Ursula Kammlott, R; Kuglstatter, A; Goldstein, D Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392982&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25104303 163342006 CHEMBL2152382 C04080 ZINC43201156 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50726837 FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12 InChI=1S/C15H11F3N6O/c16-15(17,18)7-19-13-12-10(3-4-25-12)22-14(23-13)21-9-2-1-8-6-20-24-11(8)5-9/h1-6H,7H2,(H,20,24)(H2,19,21,22,23) FMTZJHHPYOHWNQ-UHFFFAOYSA-N 50235820 CHEMBL4066664 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235820&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 67129970 384991562 CHEMBL4066664 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50519868 CN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+ QTHCAAFKVUWAFI-DJKKODMXSA-N 25036 CHEMBL393525::N'-[(1E)-{6-bromoimidazo[1,2-a]pyridin-3-yl}methylidene]-N,2-dimethyl-5-nitrobenzene-1-sulfonohydrazide::PIK-75, 1::US10981896, Compound PIK75::imidazopyridine derivative, 8c Cyclin-dependent kinase 7 Homo sapiens 2.5 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25036&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search F4N 6GN1 10275789 56374180 CHEMBL393525 ZINC28652818 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50519952 Cc1c(sc(=O)n1C)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C19H22N6OS/c1-13-17(27-19(26)24(13)2)16-7-8-21-18(23-16)22-14-3-5-15(6-4-14)25-11-9-20-10-12-25/h3-8,20H,9-12H2,1-2H3,(H,21,22,23) CGGMDMYBCWDOLZ-UHFFFAOYSA-N 81441 CDK Inhibitor, 14 Cyclin-dependent kinase 7 Homo sapiens 2.3 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81441&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11257553 131342015 ZINC58650237 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51075809 CS(=O)(=O)CCCOc1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)C(=O)N2CCC(O)CC2)n1 InChI=1S/C28H37N5O5S/c1-39(36,37)19-3-18-38-25-5-2-4-24-23(25)13-17-33(24)26-10-14-29-28(31-26)30-21-8-6-20(7-9-21)27(35)32-15-11-22(34)12-16-32/h2,4-5,10,13-14,17,20-22,34H,3,6-9,11-12,15-16,18-19H2,1H3,(H,29,30,31)/t20-,21- NXWXUDHOUKWAQU-MEMLXQNLSA-N 50440018 CHEMBL2425628 Cyclin-dependent kinase 7 Homo sapiens 620 ChEMBL 10.1016/j.bmcl.2012.12.047 10.7270/Q20003HK 23352510 Palmer, WS; Alam, M; Arzeno, HB; Chang, KC; Dunn, JP; Goldstein, DM; Gong, L; Goyal, B; Hermann, JC; Hogg, JH; Hsieh, G; Jahangir, A; Janson, C; Jin, S; Ursula Kammlott, R; Kuglstatter, A; Lukacs, C; Michoud, C; Niu, L; Reuter, DC; Shao, A; Silva, T; Trejo-Martin, TA; Stein, K; Tan, YC; Tivitmahaisoon, P; Tran, P; Wagner, P; Weller, P; Wu, SY Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440018&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 58017084 175452335 CHEMBL2425628 ZINC88385502 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51076285 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(OC)cc2)-c2ccccc2)cc1 InChI=1S/C25H22N4O3S/c1-31-20-12-8-17(9-13-20)23-22(16-29(28-23)19-6-4-3-5-7-19)24(30)27-25(33)26-18-10-14-21(32-2)15-11-18/h3-16H,1-2H3,(H2,26,27,30,33) YECDMWPRVSKSOX-UHFFFAOYSA-N 50440135 CHEMBL2426395 Cyclin-dependent kinase 7 Homo sapiens 1423 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440135&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72707853 175452452 CHEMBL2426395 ZINC96283865 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51076286 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(F)cc2)-c2ccccc2)cc1 InChI=1S/C24H19FN4O2S/c1-31-20-13-11-18(12-14-20)26-24(32)27-23(30)21-15-29(19-5-3-2-4-6-19)28-22(21)16-7-9-17(25)10-8-16/h2-15H,1H3,(H2,26,27,30,32) OQEFZDKDXVHSRX-UHFFFAOYSA-N 50440136 CHEMBL2426391 Cyclin-dependent kinase 7 Homo sapiens 1642 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440136&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72707790 175452453 CHEMBL2426391 ZINC96283866 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51076287 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(Cl)cc2)-c2ccccc2)cc1 InChI=1S/C24H19ClN4O2S/c1-31-20-13-11-18(12-14-20)26-24(32)27-23(30)21-15-29(19-5-3-2-4-6-19)28-22(21)16-7-9-17(25)10-8-16/h2-15H,1H3,(H2,26,27,30,32) BASWGBOBVOPWNF-UHFFFAOYSA-N 50440137 CHEMBL2426387 Cyclin-dependent kinase 7 Homo sapiens 1645 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440137&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72707728 175452454 CHEMBL2426387 ZINC96283867 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51076288 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccc(C)cc2)-c2ccccc2)cc1 InChI=1S/C25H22N4O2S/c1-17-8-10-18(11-9-17)23-22(16-29(28-23)20-6-4-3-5-7-20)24(30)27-25(32)26-19-12-14-21(31-2)15-13-19/h3-16H,1-2H3,(H2,26,27,30,32) XYZIPKBTOPMPRH-UHFFFAOYSA-N 50440138 CHEMBL2426383 Cyclin-dependent kinase 7 Homo sapiens 1788 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440138&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72707724 175452455 CHEMBL2426383 ZINC96283868 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51076289 COc1ccc(NC(=S)NC(=O)c2cn(nc2-c2ccccc2)-c2ccccc2)cc1 InChI=1S/C24H20N4O2S/c1-30-20-14-12-18(13-15-20)25-24(31)26-23(29)21-16-28(19-10-6-3-7-11-19)27-22(21)17-8-4-2-5-9-17/h2-16H,1H3,(H2,25,26,29,31) BEFVJTSMLGHNEY-UHFFFAOYSA-N 50440139 CHEMBL2426399 Cyclin-dependent kinase 7 Homo sapiens 1876 ChEMBL 10.1016/j.ejmech.2013.07.003 10.7270/Q2PK0HKH 23933045 Sun, J; Lv, XH; Qiu, HY; Wang, YT; Du, QR; Li, DD; Yang, YH; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440139&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72707651 175452456 CHEMBL2426399 ZINC96283869 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50726878 CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 InChI=1S/C18H19F3N6O/c1-2-8-23-16(28)11-3-5-12(6-4-11)25-17-26-14-13(7-9-22-14)15(27-17)24-10-18(19,20)21/h3-7,9H,2,8,10H2,1H3,(H,23,28)(H3,22,24,25,26,27) UJBJWYNPUOLFIZ-UHFFFAOYSA-N 50235830 CHEMBL2006765 Cyclin-dependent kinase 7 Homo sapiens 2730 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235830&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16129448 384991572 CHEMBL2006765 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50727007 Cc1n[nH]c2cc(Nc3nc(NC4CC4)c4occc4n3)ccc12 InChI=1S/C17H16N6O/c1-9-12-5-4-11(8-14(12)23-22-9)19-17-20-13-6-7-24-15(13)16(21-17)18-10-2-3-10/h4-8,10H,2-3H2,1H3,(H,22,23)(H2,18,19,20,21) MDWXVGCLSBQVMP-UHFFFAOYSA-N 50235833 CHEMBL4062803 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235833&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 77V 5T68 67130050 384991575 CHEMBL4062803 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50727202 FC(F)(F)CNc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc2ccoc12 InChI=1S/C18H17ClF3N5O2/c19-12-9-11(1-2-14(12)27-4-7-28-8-5-27)24-17-25-13-3-6-29-15(13)16(26-17)23-10-18(20,21)22/h1-3,6,9H,4-5,7-8,10H2,(H2,23,24,25,26) WHFIWINTCCNYQZ-UHFFFAOYSA-N 50235817 CHEMBL4078893 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.09.077 10.7270/Q2WQ061V 27789138 Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235817&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 68755406 384991559 CHEMBL4078893 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790962 O=C(NC12CC3CC(C1)CC(C3)(C2)NC(=O)OCc1ccccc1)OCc1ccccc1 InChI=1S/C26H30N2O4/c29-23(31-16-19-7-3-1-4-8-19)27-25-12-21-11-22(13-25)15-26(14-21,18-25)28-24(30)32-17-20-9-5-2-6-10-20/h1-10,21-22H,11-18H2,(H,27,29)(H,28,30) ASNRMEONDJCIPT-UHFFFAOYSA-N 395705 4-amino-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)tricyclo[3.3.1.13,7]decanyl)benzamide::US10308648, Compound 100 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395705&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118034016 405265784 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790963 Nc1ccc(cc1)C(=O)N[C@H]1C[C@H](O)C[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395706 (+/−)-4-amino-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-5-hydroxycyclohexyl)benzamide::US10308648, Compound 101 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395706&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290976 405265785 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790964 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395707 4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 102::US10865206, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395707&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033991 405265786 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790965 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C2CC2)c(n1)-c1c[nH]c2ccccc12 395708 4-amino-N-((1S,3R)-3-(5-cyclopropyl-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 103::US10865206, Compound 103 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395708&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025488 405265787 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790966 Nc1ccc(cc1)C(=O)NC12CC(C1)(CCC2)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C26H25ClN6O/c27-20-13-30-24(31-22(20)19-12-29-21-5-2-1-4-18(19)21)33-26-11-3-10-25(14-26,15-26)32-23(34)16-6-8-17(28)9-7-16/h1-2,4-9,12-13,29H,3,10-11,14-15,28H2,(H,32,34)(H,30,31,33) ZTXOOBWQLUXXDV-UHFFFAOYSA-N 395709 4-amino-N-(5-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)bicyclo[3.1.1]heptan-1-yl)benzamide::US10308648, Compound 104::US10865206, Compound 104 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395709&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025260 405265788 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790967 CN(C)CCCC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395710 N-((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)-4-(4-(dimethylamino)butanamido)benzamide ::US10308648, Compound 105::US10865206, Compound 105 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395710&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290981 405265789 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790968 Nc1ccc(NC(=O)[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 395711 (1S,3R)—N-(4-aminophenyl)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexanecarboxamide::US10308648, Compound 106::US10865206, Compound 106 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395711&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118034014 405265790 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790969 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C#N)c(n1)-c1c[nH]c2ccccc12 395712 4-amino-N-((1S,3R)-3-(5-cyano-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 107::US10865206, Compound 107 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395712&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025265 405265791 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790970 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1cccnc1 InChI=1S/C22H23ClN6O/c23-19-13-26-22(29-20(19)15-3-2-10-25-12-15)28-18-5-1-4-17(11-18)27-21(30)14-6-8-16(24)9-7-14/h2-3,6-10,12-13,17-18H,1,4-5,11,24H2,(H,27,30)(H,26,28,29)/t17-,18+/m0/s1 CDRVASIYWVWJCA-ZWKOTPCHSA-N 395713 4-amino-N-((1S,3R)-3-(5-chloro-4-(pyridin-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 108::US10865206, Compound 108 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395713&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118034031 405265792 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790971 Nc1ccc(cc1)S(=O)(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395714 US10308648, Compound 109::US10865206, Compound 109 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395714&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025250 405265793 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790972 Nc1ccc(cc1)C(=O)N[C@H]1C[C@@H](F)C[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395715 (+/−)-4-amino-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-5-fluorocyclohexyl)benzamide::US10308648, Compound 110 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395715&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121284459 405265794 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790973 Nc1ccc(cc1F)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395716 4-amino-N-(1S,3R)-3-(5-chloro-4-(4H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-3-fluorobenzamide::US10308648, Compound 111::US10865206, Compound 111 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395716&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025493 405265795 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790974 Nc1ccc(C(=O)N[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 395717 4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-2-fluorobenzamide::US10308648, Compound 112::US10865206, Compound 112 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025248 405265796 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790975 NC(=O)C(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395718 N1-(4-(((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)carbamoyl)phenyl)oxalamide ::US10308648, Compound 113::US10865206, Compound 113 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395718&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290979 405265797 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 790976 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1nccc(n1)-c1c[nH]c2ccccc12 395719 N-((1S,3R)-3-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-4-aminobenzamide::US10308648, Compound 114 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2RR21KT aid1799061 US10308648 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, AM; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395719&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033994 405265798 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097618 CC(C)(C)c1cnc(CSc2cnc(NC3CCCC(C3)Nc3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H33N5O2S2/c1-5-22(32)30-18-11-9-17(10-12-18)29-19-7-6-8-20(13-19)31-25-28-15-24(35-25)34-16-23-27-14-21(33-23)26(2,3)4/h5,9-12,14-15,19-20,29H,1,6-8,13,16H2,2-4H3,(H,28,31)(H,30,32) KHUWOOWXQFGVBZ-UHFFFAOYSA-N 50539906 CHEMBL4648005::US11142507, Compound MFH-3-35-1 Cyclin-dependent kinase 7 Homo sapiens 557 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539906&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358323 442141469 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097621 COc1cc(NC(=O)C=C)ccc1C(=O)N1CCC[C@H](C1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C27H33N5O4S2/c1-6-22(33)30-17-9-10-19(20(12-17)35-5)25(34)32-11-7-8-18(15-32)31-26-29-14-24(38-26)37-16-23-28-13-21(36-23)27(2,3)4/h6,9-10,12-14,18H,1,7-8,11,15-16H2,2-5H3,(H,29,31)(H,30,33)/t18-/m1/s1 BLVLYWOLAOAKQM-GOSISDBHSA-N 519532 US11142507, Compound MFH-3-81-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519532&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358475 461596987 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097624 CC(C)(C)c1cnc(CSc2cnc(NC3CCCC(C3)C(=O)N3CCC(CC3)NC(=O)C=C)s2)o1 InChI=1S/C26H37N5O3S2/c1-5-21(32)29-18-9-11-31(12-10-18)24(33)17-7-6-8-19(13-17)30-25-28-15-23(36-25)35-16-22-27-14-20(34-22)26(2,3)4/h5,14-15,17-19H,1,6-13,16H2,2-4H3,(H,28,30)(H,29,32) DESNULOADHHAOA-UHFFFAOYSA-N 519533 US11142507, Compound MFH-3-88-1 Cyclin-dependent kinase 7 Homo sapiens 4400 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749955 461596988 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097627 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCC[C@H](C3)Oc3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H32N4O3S2/c1-5-22(31)29-17-9-11-19(12-10-17)32-20-8-6-7-18(13-20)30-25-28-15-24(35-25)34-16-23-27-14-21(33-23)26(2,3)4/h5,9-12,14-15,18,20H,1,6-8,13,16H2,2-4H3,(H,28,30)(H,29,31)/t18-,20-/m1/s1 CWZJACZPSOWPBL-UYAOXDASSA-N 519534 US11142507, Compound MFH-3-103-1 Cyclin-dependent kinase 7 Homo sapiens 1280 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358314 461596989 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097630 FC(F)(F)c1cc(NCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)ncc1Cl InChI=1S/C25H24ClF3N6O2S/c1-2-22(36)33-16-7-5-15(6-8-16)23(37)35-9-3-4-17(14-35)34-24-32-12-18(38-24)11-30-21-10-19(25(27,28)29)20(26)13-31-21/h2,5-8,10,12-13,17H,1,3-4,9,11,14H2,(H,30,31)(H,32,34)(H,33,36)/t17-/m1/s1 ALIURTYZQYAYDF-QGZVFWFLSA-N 519535 US11142507, Compound MFH-3-107-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519535&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749951 461596990 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097633 CC(C)(C)c1cnc(\C=C\c2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H31N5O3S/c1-5-23(33)30-19-10-8-18(9-11-19)25(34)32-14-6-7-20(17-32)31-26-29-15-21(36-26)12-13-24-28-16-22(35-24)27(2,3)4/h5,8-13,15-16,20H,1,6-7,14,17H2,2-4H3,(H,29,31)(H,30,33)/b13-12+/t20-/m1/s1 BLUORUUGUNHQIW-DRUFCSCSSA-N 519536 US11142507, Compound MFH-3-110-1 Cyclin-dependent kinase 7 Homo sapiens 3400 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519536&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749872 461596991 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097636 CC(C)(C)c1cnc(CCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H33N5O3S/c1-5-23(33)30-19-10-8-18(9-11-19)25(34)32-14-6-7-20(17-32)31-26-29-15-21(36-26)12-13-24-28-16-22(35-24)27(2,3)4/h5,8-11,15-16,20H,1,6-7,12-14,17H2,2-4H3,(H,29,31)(H,30,33)/t20-/m1/s1 NXZXWOASWYOLBZ-HXUWFJFHSA-N 50539916 CHEMBL4636251::US11142507, Compound MFH-3-116-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539916&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126673128 442141479 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097639 FC(F)(F)c1cccc(COCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)c1 InChI=1S/C27H27F3N4O3S/c1-2-24(35)32-21-10-8-19(9-11-21)25(36)34-12-4-7-22(15-34)33-26-31-14-23(38-26)17-37-16-18-5-3-6-20(13-18)27(28,29)30/h2-3,5-6,8-11,13-14,22H,1,4,7,12,15-17H2,(H,31,33)(H,32,35)/t22-/m1/s1 BHQIRJHDRSUBAW-JOCHJYFZSA-N 519538 US11142507, Compound MFH-3-120-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519538&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358143 461596993 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097642 CC(C)(C)c1cnc(COCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H33N5O4S/c1-5-23(33)30-19-10-8-18(9-11-19)25(34)32-12-6-7-20(15-32)31-26-29-13-21(37-26)16-35-17-24-28-14-22(36-24)27(2,3)4/h5,8-11,13-14,20H,1,6-7,12,15-17H2,2-4H3,(H,29,31)(H,30,33)/t20-/m1/s1 YPSQOIGPBAPUFM-HXUWFJFHSA-N 50539917 CHEMBL4634832::US11142507, Compound MFH-3-128-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539917&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749947 442141480 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097645 CC(C)(C)c1cnc(CNCc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C27H34N6O3S/c1-5-23(34)31-19-10-8-18(9-11-19)25(35)33-12-6-7-20(17-33)32-26-30-14-21(37-26)13-28-16-24-29-15-22(36-24)27(2,3)4/h5,8-11,14-15,20,28H,1,6-7,12-13,16-17H2,2-4H3,(H,30,32)(H,31,34)/t20-/m1/s1 BULBBWSMORELAY-HXUWFJFHSA-N 50539918 CHEMBL4632815::US11142507, Compound MFH-3-137-1 Cyclin-dependent kinase 7 Homo sapiens 8870 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539918&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749889 442141481 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097648 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)S(=O)(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C25H31N5O4S3/c1-5-21(31)28-17-8-10-19(11-9-17)37(32,33)30-12-6-7-18(15-30)29-24-27-14-23(36-24)35-16-22-26-13-20(34-22)25(2,3)4/h5,8-11,13-14,18H,1,6-7,12,15-16H2,2-4H3,(H,27,29)(H,28,31)/t18-/m1/s1 AYHWTHWMLDRSHF-GOSISDBHSA-N 519542 US11142507, Compound MFH-3-151-1 Cyclin-dependent kinase 7 Homo sapiens 224 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519542&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358497 461596997 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097651 C=CC(=O)Nc1ccc(cc1)S(=O)N1CCCC(C1)Nc1ncc(SCc2ccncc2)s1 InChI=1S/C23H25N5O2S3/c1-2-21(29)26-18-5-7-20(8-6-18)33(30)28-13-3-4-19(15-28)27-23-25-14-22(32-23)31-16-17-9-11-24-12-10-17/h2,5-12,14,19H,1,3-4,13,15-16H2,(H,25,27)(H,26,29) VESPBSYZPFSPLX-UHFFFAOYSA-N 519543 US11142507, Compound MFH-3-179-1 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519543&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749914 461596998 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097654 C=CC(=O)Nc1ccc(cc1)S(=O)N1CCCC(C1)Nc1ncc(SCc2cccnc2)s1 InChI=1S/C23H25N5O2S3/c1-2-21(29)26-18-7-9-20(10-8-18)33(30)28-12-4-6-19(15-28)27-23-25-14-22(32-23)31-16-17-5-3-11-24-13-17/h2-3,5,7-11,13-14,19H,1,4,6,12,15-16H2,(H,25,27)(H,26,29) WMPKFJAZEBFMOM-UHFFFAOYSA-N 519544 US11142507, Compound MFH-3-191-1 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519544&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749869 461596999 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097657 C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCc2ccccn2)s1 InChI=1S/C24H25N5O2S2/c1-2-21(30)27-18-10-8-17(9-11-18)23(31)29-13-5-7-19(15-29)28-24-26-14-22(33-24)32-16-20-6-3-4-12-25-20/h2-4,6,8-12,14,19H,1,5,7,13,15-16H2,(H,26,28)(H,27,30)/t19-/m1/s1 NBRFXZJIFIXQNC-LJQANCHMSA-N 519545 US11142507, Compound MFH-3-203-1 Cyclin-dependent kinase 7 Homo sapiens 2870 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519545&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749945 461597000 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097660 FC(F)(F)c1ncc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)cn1 InChI=1S/C24H23F3N6O2S2/c1-2-19(34)31-17-7-5-16(6-8-17)21(35)33-9-3-4-18(13-33)32-23-30-12-20(37-23)36-14-15-10-28-22(29-11-15)24(25,26)27/h2,5-8,10-12,18H,1,3-4,9,13-14H2,(H,30,32)(H,31,34)/t18-/m1/s1 QNQVGWPXBWZBQX-GOSISDBHSA-N 50539914 CHEMBL4637498::US11142507, Compound MFH-3-201-1 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539914&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358263 442141477 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097663 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)S(=O)(=O)c3ccc4N(CCc4c3)C(=O)C=C)s2)o1 InChI=1S/C27H33N5O4S3/c1-5-24(33)32-12-10-18-13-20(8-9-21(18)32)39(34,35)31-11-6-7-19(16-31)30-26-29-15-25(38-26)37-17-23-28-14-22(36-23)27(2,3)4/h5,8-9,13-15,19H,1,6-7,10-12,16-17H2,2-4H3,(H,29,30)/t19-/m1/s1 ZQNYFQLNCVPOKT-LJQANCHMSA-N 519547 US11142507, Compound MFH-3-168-1 Cyclin-dependent kinase 7 Homo sapiens 447 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519547&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358310 461597002 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097666 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCC[C@H](C3)Oc3ccc(NC(=O)C=C)cc3C(F)(F)F)s2)o1 InChI=1S/C27H31F3N4O3S2/c1-5-22(35)33-17-9-10-20(19(12-17)27(28,29)30)36-18-8-6-7-16(11-18)34-25-32-14-24(39-25)38-15-23-31-13-21(37-23)26(2,3)4/h5,9-10,12-14,16,18H,1,6-8,11,15H2,2-4H3,(H,32,34)(H,33,35)/t16-,18-/m1/s1 UULNNXNBBBWXDG-SJLPKXTDSA-N 519548 US11142507, Compound MFH-3-192-1 Cyclin-dependent kinase 7 Homo sapiens 498 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519548&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749949 461597003 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097669 C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCC2CCOCC2)s1 InChI=1S/C24H30N4O3S2/c1-2-21(29)26-19-7-5-18(6-8-19)23(30)28-11-3-4-20(15-28)27-24-25-14-22(33-24)32-16-17-9-12-31-13-10-17/h2,5-8,14,17,20H,1,3-4,9-13,15-16H2,(H,25,27)(H,26,29)/t20-/m1/s1 XPTUNGFRXJHQJG-HXUWFJFHSA-N 50539915 CHEMBL4643754::US11142507, Compound MFH-4-4-1 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539915&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749966 442141478 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097672 C=CC(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCc2cncnc2)s1 InChI=1S/C23H24N6O2S2/c1-2-20(30)27-18-7-5-17(6-8-18)22(31)29-9-3-4-19(13-29)28-23-26-12-21(33-23)32-14-16-10-24-15-25-11-16/h2,5-8,10-12,15,19H,1,3-4,9,13-14H2,(H,26,28)(H,27,30)/t19-/m1/s1 XUDADWUSJUXKJW-LJQANCHMSA-N 519550 US11142507, Compound MFH-4-10-1 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519550&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358382 461597005 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097675 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C29H38N6O3S2/c1-29(2,3)23-16-30-25(38-23)19-39-26-17-31-28(40-26)33-22-8-6-15-35(18-22)27(37)20-10-12-21(13-11-20)32-24(36)9-7-14-34(4)5/h7,9-13,16-17,22H,6,8,14-15,18-19H2,1-5H3,(H,31,33)(H,32,36)/b9-7+/t22-/m1/s1 LRXFEHJUJZDISP-FGBWHXJSSA-N 519551 US11142507, Compound MFH-4-13-1 Cyclin-dependent kinase 7 Homo sapiens 5000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519551&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358233 461597006 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097678 CN(C)C\C=C\C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC[C@H](C1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C28H38N6O4S3/c1-28(2,3)23-16-29-25(38-23)19-39-26-17-30-27(40-26)32-21-8-6-15-34(18-21)41(36,37)22-12-10-20(11-13-22)31-24(35)9-7-14-33(4)5/h7,9-13,16-17,21H,6,8,14-15,18-19H2,1-5H3,(H,30,32)(H,31,35)/b9-7+/t21-/m1/s1 MKDYTOGJVAOMKI-WFNSPDMASA-N 519552 US11142507, Compound MFH-4-40-1 Cyclin-dependent kinase 7 Homo sapiens 158 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519552&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358137 461597007 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097681 CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C25H29N5O3S2/c1-5-20(31)28-17-8-6-16(7-9-17)23(32)30-11-10-18(14-30)29-24-27-13-22(35-24)34-15-21-26-12-19(33-21)25(2,3)4/h5-9,12-13,18H,1,10-11,14-15H2,2-4H3,(H,27,29)(H,28,31)/t18-/m1/s1 DWBSENKAVBVZEJ-GOSISDBHSA-N 519553 US11142507, Compound MFH-4-70-1 Cyclin-dependent kinase 7 Homo sapiens 242 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519553&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358221 461597008 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097684 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1 InChI=1S/C28H36N6O3S2/c1-28(2,3)22-15-29-24(37-22)18-38-25-16-30-27(39-25)32-21-12-14-34(17-21)26(36)19-8-10-20(11-9-19)31-23(35)7-6-13-33(4)5/h6-11,15-16,21H,12-14,17-18H2,1-5H3,(H,30,32)(H,31,35)/b7-6+/t21-/m1/s1 ZXWDEAQOOQXIND-IRUYWQDXSA-N 519554 US11142507, Compound MFH-4-73-1 Cyclin-dependent kinase 7 Homo sapiens 230 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519554&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749897 461597009 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097582 C=CC(=O)Nc1cccc(c1)C(=O)Nc1ncc(s1)N1CCOCC1 InChI=1S/C17H18N4O3S/c1-2-14(22)19-13-5-3-4-12(10-13)16(23)20-17-18-11-15(25-17)21-6-8-24-9-7-21/h2-5,10-11H,1,6-9H2,(H,19,22)(H,18,20,23) VYQFYUJCEGRLIP-UHFFFAOYSA-N 519455 US11142507, Compound THZ-CE-B-17 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519455&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358321 461596920 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097585 CN1CCN(CC1)c1cnc(NC(=O)c2cccc(NC(=O)C=C)c2)s1 InChI=1S/C18H21N5O2S/c1-3-15(24)20-14-6-4-5-13(11-14)17(25)21-18-19-12-16(26-18)23-9-7-22(2)8-10-23/h3-6,11-12H,1,7-10H2,2H3,(H,20,24)(H,19,21,25) OGMXGSAAVJTTCI-UHFFFAOYSA-N 519456 US11142507, Compound THZ-CE-B-18 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519456&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358553 461596921 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097588 CCN1CCN(CC1)c1cnc(NC(=O)c2cccc(NC(=O)C=C)c2)s1 InChI=1S/C19H23N5O2S/c1-3-16(25)21-15-7-5-6-14(12-15)18(26)22-19-20-13-17(27-19)24-10-8-23(4-2)9-11-24/h3,5-7,12-13H,1,4,8-11H2,2H3,(H,21,25)(H,20,22,26) AQTQTFRVQOIEGB-UHFFFAOYSA-N 519476 US11142507, Compound THZ-CE-B-19 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519476&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749930 461596941 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097591 CC(C)(C)OC(=O)N1CCN(CC1)c1cnc(NC(=O)c2cccc(NC(=O)C=C)c2)s1 InChI=1S/C22H27N5O4S/c1-5-17(28)24-16-8-6-7-15(13-16)19(29)25-20-23-14-18(32-20)26-9-11-27(12-10-26)21(30)31-22(2,3)4/h5-8,13-14H,1,9-12H2,2-4H3,(H,24,28)(H,23,25,29) HVAWQHDMHMNOAP-UHFFFAOYSA-N 519479 US11142507, Compound THZ-CE-B-20 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519479&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749958 461596944 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097594 CN(C)C1CCN(CC1)c1cnc(NC(=O)c2cccc(NC(=O)C=C)c2)s1 InChI=1S/C20H25N5O2S/c1-4-17(26)22-15-7-5-6-14(12-15)19(27)23-20-21-13-18(28-20)25-10-8-16(9-11-25)24(2)3/h4-7,12-13,16H,1,8-11H2,2-3H3,(H,22,26)(H,21,23,27) RRPYRSMWUNOMAJ-UHFFFAOYSA-N 519480 US11142507, Compound THZ-CE-B-22 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519480&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749880 461596945 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097597 CC(C)(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32) COGUZYALRYMQTD-UHFFFAOYSA-N 519490 US11142507, Compound MFH-2-90-1 Cyclin-dependent kinase 7 Homo sapiens 6020 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519490&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358305 461596955 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097600 CC(C)(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)C3CCC(CC3)NC(=O)C=C)s2)o1 InChI=1S/C26H37N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,13-14,17-19H,1,6-12,15-16H2,2-4H3,(H,28,30)(H,29,32) IQMPZJYDZWUWHT-UHFFFAOYSA-N 519493 US11142507, Compound MFH-2-95-1 Cyclin-dependent kinase 7 Homo sapiens 5550 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519493&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749875 461596958 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097603 CC(C)(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)N3CCC(CC3)NC(=O)C=C)s2)o1 InChI=1S/C25H36N6O3S2/c1-5-20(32)28-17-8-11-30(12-9-17)24(33)31-10-6-7-18(15-31)29-23-27-14-22(36-23)35-16-21-26-13-19(34-21)25(2,3)4/h5,13-14,17-18H,1,6-12,15-16H2,2-4H3,(H,27,29)(H,28,32) GAYYZQYKXQJXQA-UHFFFAOYSA-N 519500 US11142507, Compound MFH-2-104-1 Cyclin-dependent kinase 7 Homo sapiens 6170 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519500&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358230 461596960 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097606 CC(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C25H29N5O3S2/c1-4-21(31)28-18-9-7-17(8-10-18)24(32)30-11-5-6-19(14-30)29-25-27-13-23(35-25)34-15-22-26-12-20(33-22)16(2)3/h4,7-10,12-13,16,19H,1,5-6,11,14-15H2,2-3H3,(H,27,29)(H,28,31) JNVRYZQOUCZHKV-UHFFFAOYSA-N 519527 US11142507, Compound MFH-2-92-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519527&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749953 461596982 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097609 CC(C)(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)Oc3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C26H31N5O4S2/c1-5-21(32)29-17-8-10-19(11-9-17)34-25(33)31-12-6-7-18(15-31)30-24-28-14-23(37-24)36-16-22-27-13-20(35-22)26(2,3)4/h5,8-11,13-14,18H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32) UMHPDYCYVZAGAH-UHFFFAOYSA-N 519528 US11142507, Compound MFH-2-102-1 Cyclin-dependent kinase 7 Homo sapiens 362 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519528&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749961 461596983 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097612 CC(C)(C)c1cnc(CSc2cnc(NC3CCCN(C3)C(=O)c3ccc(CNC(=O)C=C)cc3)s2)o1 InChI=1S/C27H33N5O3S2/c1-5-22(33)28-13-18-8-10-19(11-9-18)25(34)32-12-6-7-20(16-32)31-26-30-15-24(37-26)36-17-23-29-14-21(35-23)27(2,3)4/h5,8-11,14-15,20H,1,6-7,12-13,16-17H2,2-4H3,(H,28,33)(H,30,31) WRYQEGMCPJCDEP-UHFFFAOYSA-N 519529 US11142507, Compound MFH-2-98-1 Cyclin-dependent kinase 7 Homo sapiens 9230 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=519529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=519529&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137358406 461596984 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1097615 CC(C)(C)c1cnc(CSc2nnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 InChI=1S/C25H30N6O3S2/c1-5-20(32)27-17-10-8-16(9-11-17)22(33)31-12-6-7-18(14-31)28-23-29-30-24(36-23)35-15-21-26-13-19(34-21)25(2,3)4/h5,8-11,13,18H,1,6-7,12,14-15H2,2-4H3,(H,27,32)(H,28,29)/t18-/m1/s1 ZGTBRXCHDKWPQT-GOSISDBHSA-N 50539921 CHEMBL4649802::US11142507, Compound MFH-2-25-1 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2DN486D US11142507 Gray, NS; Zhang, T; Kwiatkowski, NP; Hao, M Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539921&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145749881 442141484 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51139802 CSc1ncc-2c(CCc3cnc(Nc4ccc(cc4)C(=O)N(C)CCN(C)C)nc-23)n1 InChI=1S/C23H27N7OS/c1-29(2)11-12-30(3)21(31)15-5-8-17(9-6-15)26-22-24-13-16-7-10-19-18(20(16)28-22)14-25-23(27-19)32-4/h5-6,8-9,13-14H,7,10-12H2,1-4H3,(H,24,26,28) HQYBJDBTJVHYKB-UHFFFAOYSA-N 50467169 CHEMBL4294760 Cyclin-dependent kinase 7 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2018.08.035 10.7270/Q2NP274V 30197029 Hu, X; Zhao, H; Wang, Y; Liu, Z; Feng, B; Tang, C Jiangnan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467169&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145994117 433934434 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907264 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 7 Homo sapiens 667 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907267 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C27H30F2N8O/c1-15(2)37-16(3)31-26-19(28)10-18(11-22(26)37)25-20(29)12-30-27(34-25)33-23-7-6-17-13-36(9-8-21(17)32-23)24(38)14-35(4)5/h6-7,10-12,15H,8-9,13-14H2,1-5H3,(H,30,32,33,34) SSVSKCKWUAPYHI-UHFFFAOYSA-N 50458034 CHEMBL4212532::US10662186, Compound 5::US10988476, Compound I-5 Cyclin-dependent kinase 7 Homo sapiens 913 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458034&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114516 433925299 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907270 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C)CCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13(2)33-14(3)28-23-17(25)9-16(10-20(23)33)22-18(26)11-27-24(31-22)30-21-6-5-15-12-32(4)8-7-19(15)29-21/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,27,29,30,31) AXTGGTFVALFVDO-UHFFFAOYSA-N 444482 US10662186, Compound 8::US10988476, Compound I-8 Cyclin-dependent kinase 7 Homo sapiens 393 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444482&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196664 440706730 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907273 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CCO)ncc1F InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)10-17(11-21(25)35)24-19(28)12-29-26(33-24)32-22-5-4-16-13-34(23(37)7-9-36)8-6-20(16)31-22/h4-5,10-12,14,36H,6-9,13H2,1-3H3,(H,29,31,32,33) JDIAYVMOUUKPNK-UHFFFAOYSA-N 444483 US10662186, Compound 9::US10988476, Compound I-9 Cyclin-dependent kinase 7 Homo sapiens 13157 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444483&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196659 440706731 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907276 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)12-19(13-24(28)39(17)20-6-4-5-7-20)27-22(31)14-32-29(36-27)35-25-9-8-18-15-38(11-10-23(18)34-25)26(40)16-37(2)3/h8-9,12-14,20H,4-7,10-11,15-16H2,1-3H3,(H,32,34,35,36) ZFXSUJXETQKSKI-UHFFFAOYSA-N 444493 US10662186, Compound 22::US10988476, Compound I-22 Cyclin-dependent kinase 7 Homo sapiens 1045 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444493&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196666 440706741 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907279 CN1CCN(CC(=C)N2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(C6CCCC6)c5c4)ccc3C2)CC1 InChI=1S/C33H39F2N9/c1-21(19-42-14-12-41(3)13-15-42)43-11-10-28-23(20-43)8-9-30(38-28)39-33-36-18-27(35)31(40-33)24-16-26(34)32-29(17-24)44(22(2)37-32)25-6-4-5-7-25/h8-9,16-18,25H,1,4-7,10-15,19-20H2,2-3H3,(H,36,38,39,40) FGFWZFYILZKNBW-UHFFFAOYSA-N 444494 US10662186, Compound 23 Cyclin-dependent kinase 7 Homo sapiens 801 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444494&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155802632 440706742 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907282 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCOCC2)ncc1F InChI=1S/C29H32F2N8O2/c1-17(2)39-18(3)33-28-21(30)12-20(13-24(28)39)27-22(31)14-32-29(36-27)35-25-5-4-19-15-38(7-6-23(19)34-25)26(40)16-37-8-10-41-11-9-37/h4-5,12-14,17H,6-11,15-16H2,1-3H3,(H,32,34,35,36) HXKORJQOSCRLJP-UHFFFAOYSA-N 444495 US10662186, Compound 24::US10988476, Compound I-24 Cyclin-dependent kinase 7 Homo sapiens 2893 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444495&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114319 440706743 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907285 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35) SSIOYGMEKCPFAV-UHFFFAOYSA-N 444496 US10662186, Compound 25::US10988476, Compound I-25 Cyclin-dependent kinase 7 Homo sapiens 978 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444496&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196667 440706744 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907288 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 7 Homo sapiens 574 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907291 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C=C)ncc1F InChI=1S/C26H25F2N7O/c1-5-23(36)34-9-8-20-16(13-34)6-7-22(31-20)32-26-29-12-19(28)24(33-26)17-10-18(27)25-21(11-17)35(14(2)3)15(4)30-25/h5-7,10-12,14H,1,8-9,13H2,2-4H3,(H,29,31,32,33) SOHOEERULHWXJB-UHFFFAOYSA-N 444516 US10662186, Compound 38::US10988476, Compound I-38 Cyclin-dependent kinase 7 Homo sapiens >30000 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444516&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114603 440706763 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907294 CN(C)CCOC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O2/c1-16-32-26-20(29)12-18(13-23(26)38(16)19-5-6-19)25-21(30)14-31-27(35-25)34-24-7-4-17-15-37(9-8-22(17)33-24)28(39)40-11-10-36(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,33,34,35) XLZHLULRODUOPS-UHFFFAOYSA-N 444525 US10662186, Compound 46::US10988476, Compound I-46 Cyclin-dependent kinase 7 Homo sapiens 1280 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444525&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196818 440706772 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907297 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 7 Homo sapiens 563 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907300 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H26F2N8O2/c1-14-31-24-18(27)10-16(11-21(24)36(14)17-3-4-17)23-19(28)12-30-25(34-23)33-22-5-2-15-13-35(8-6-20(15)32-22)26(38)29-7-9-37/h2,5,10-12,17,37H,3-4,6-9,13H2,1H3,(H,29,38)(H,30,32,33,34) XTSFMAFWRLGELC-UHFFFAOYSA-N 444530 US10662186, Compound 50::US10988476, Compound I-50 Cyclin-dependent kinase 7 Homo sapiens 718 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444530&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196796 440706777 C04080 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907303 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-32-26-19(28)10-17(11-22(26)37(15)18-4-3-5-18)25-20(29)12-31-27(35-25)34-23-7-6-16-14-36(24(38)13-30-2)9-8-21(16)33-23/h6-7,10-12,18,30H,3-5,8-9,13-14H2,1-2H3,(H,31,33,34,35) UTDIUAOBXDHROL-UHFFFAOYSA-N 444531 US10662186, Compound 51::US10988476, Compound I-51 Cyclin-dependent kinase 7 Homo sapiens 1153 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444531&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196799 440706778 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907307 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-31-26-20(28)12-18(13-23(26)37(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-36(11-10-35(2)3)9-8-22(17)32-24/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) UZUCFTPPULEGQO-UHFFFAOYSA-N 444532 US10662186, Compound 52::US10988476, Compound I-52 Cyclin-dependent kinase 7 Homo sapiens 223 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444532&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196740 440706779 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907310 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)13-19(14-24(28)39(17)20-5-4-6-20)27-22(31)15-32-29(36-27)35-25-8-7-18-16-38(12-9-23(18)34-25)26(40)10-11-37(2)3/h7-8,13-15,20H,4-6,9-12,16H2,1-3H3,(H,32,34,35,36) CJOCXJOHQLURIU-UHFFFAOYSA-N 444534 US10662186, Compound 54 Cyclin-dependent kinase 7 Homo sapiens 1818 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145763676 440706781 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907313 CN1CCC[C@H]1C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H30F2N8O/c1-16-33-27-20(30)12-18(13-24(27)39(16)19-6-7-19)26-21(31)14-32-29(36-26)35-25-8-5-17-15-38(11-9-22(17)34-25)28(40)23-4-3-10-37(23)2/h5,8,12-14,19,23H,3-4,6-7,9-11,15H2,1-2H3,(H,32,34,35,36)/t23-/m0/s1 KYMNNSMBWCZWCF-QHCPKHFHSA-N 444539 US10662186, Compound 59 Cyclin-dependent kinase 7 Homo sapiens 650 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444539&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196820 440706786 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907316 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)10-19(11-23(27)38(16)13-17-4-5-17)26-21(30)12-31-28(35-26)34-24-7-6-18-14-37(9-8-22(18)33-24)25(39)15-36(2)3/h6-7,10-12,17H,4-5,8-9,13-15H2,1-3H3,(H,31,33,34,35) FEBXDTFBHZJUJT-UHFFFAOYSA-N 444540 US10662186, Compound 60::US10988476, Compound I-60 Cyclin-dependent kinase 7 Homo sapiens 1195 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444540&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196821 440706787 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907319 CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H33F2N9O/c1-17-33-27-21(30)13-19(14-24(27)40(17)20-6-7-20)26-22(31)15-32-28(36-26)35-25-8-5-18-16-39(10-9-23(18)34-25)29(41)38(4)12-11-37(2)3/h5,8,13-15,20H,6-7,9-12,16H2,1-4H3,(H,32,34,35,36) IVKYJVDFJKEXIH-UHFFFAOYSA-N 444541 US10662186, Compound 61::US10988476, Compound I-61 Cyclin-dependent kinase 7 Homo sapiens 710 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444541&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196824 440706788 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907322 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H](C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35)/t16-/m1/s1 SSIOYGMEKCPFAV-MRXNPFEDSA-N 444542 US10662186, Compound 62::US10988476, Compound I-62 Cyclin-dependent kinase 7 Homo sapiens 2819 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444542&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196777 440706789 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907326 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Cyclin-dependent kinase 7 Homo sapiens 261 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907329 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 7 Homo sapiens 1076 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907332 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 7 Homo sapiens 556 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907336 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2,3)4)21-17(26)12-28-23(32-21)31-20-6-5-14-11-27-8-7-18(14)30-20/h5-6,9-10,12,27H,7-8,11H2,1-4H3,(H,28,30,31,32) LIJUCWLALFXGCL-UHFFFAOYSA-N 444548 US10662186, Compound 68::US10988476, Compound I-68 Cyclin-dependent kinase 7 Homo sapiens 20.5 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444548&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196856 440706793 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907340 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C28H34F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2,3)4)25-21(30)15-31-27(35-25)34-24-8-7-18-16-37(12-11-36(5)6)10-9-22(18)33-24/h7-8,13-15H,9-12,16H2,1-6H3,(H,31,33,34,35) AKGTYSYXMRZPBV-UHFFFAOYSA-N 444549 US10662186, Compound 69::US10988476, Compound I-69 Cyclin-dependent kinase 7 Homo sapiens 129 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444549&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196857 440706794 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907344 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)13-19(14-24(27)38(17)20-6-7-20)26-22(30)15-31-28(35-26)34-25-8-5-18-16-37(11-4-10-36(2)3)12-9-23(18)33-25/h5,8,13-15,20H,4,6-7,9-12,16H2,1-3H3,(H,31,33,34,35) GYDXFTMHNUETBY-UHFFFAOYSA-N 444550 US10662186, Compound 70::US10988476, Compound I-70 Cyclin-dependent kinase 7 Homo sapiens 196 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444550&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196851 440706795 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907348 CN1CCC[C@@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m1/s1 DSMBDRWDECFDNR-OAQYLSRUSA-N 444555 US10662186, Compound 74::US10988476, Compound I-74 Cyclin-dependent kinase 7 Homo sapiens 104 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444555&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196858 440706800 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907352 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-18(2)39-19(3)33-28-22(30)14-21(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-20-17-38(13-10-24(20)34-26)12-7-6-11-37(4)5/h8-9,14-16,18H,10-13,17H2,1-5H3,(H,32,34,35,36) SUEYATVNHWMTSO-UHFFFAOYSA-N 444560 US10662186, Compound 79::US10988476, Compound I-79 Cyclin-dependent kinase 7 Homo sapiens 280 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444560&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196679 440706805 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907356 C[C@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m1/s1 WIAMCDYCLOMHKF-MRXNPFEDSA-N 444561 US10662186, Compound 80::US10988476, Compound I-80 Cyclin-dependent kinase 7 Homo sapiens 147 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444561&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196724 440706806 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907360 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H27F2N7/c1-4-17(5-2)34-14(3)30-24-18(26)10-16(11-21(24)34)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,4-5,8-9,12H2,1-3H3,(H,29,31,32,33) YPMOBRWHNOTUIL-UHFFFAOYSA-N 444563 US10662186, Compound 82::US10988476, Compound I-82 Cyclin-dependent kinase 7 Homo sapiens 11.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444563&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196672 440706808 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907364 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H36F2N8/c1-6-21(7-2)39-18(3)33-28-22(30)14-20(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(4)5)11-10-24(19)34-26/h8-9,14-16,21H,6-7,10-13,17H2,1-5H3,(H,32,34,35,36) POTKDJWRAMHALZ-UHFFFAOYSA-N 444564 US10662186, Compound 83::US10988476, Compound I-83 Cyclin-dependent kinase 7 Homo sapiens 38.1 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444564&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196685 440706809 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907368 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-13(15-3-4-15)34-14(2)30-24-18(26)9-17(10-21(24)34)23-19(27)12-29-25(33-23)32-22-6-5-16-11-28-8-7-20(16)31-22/h5-6,9-10,12-13,15,28H,3-4,7-8,11H2,1-2H3,(H,29,31,32,33) ANELMUPUYRZVHZ-UHFFFAOYSA-N 444565 US10662186, Compound 84::US10988476, Compound I-84 Cyclin-dependent kinase 7 Homo sapiens 16.7 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444565&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196684 440706810 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907372 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H34F2N8/c1-17(19-5-6-19)39-18(2)33-28-22(30)13-21(14-25(28)39)27-23(31)15-32-29(36-27)35-26-8-7-20-16-38(12-11-37(3)4)10-9-24(20)34-26/h7-8,13-15,17,19H,5-6,9-12,16H2,1-4H3,(H,32,34,35,36) VUKGJVXJRDQYFA-UHFFFAOYSA-N 444567 US10662186, Compound 86::US10988476, Compound I-86 Cyclin-dependent kinase 7 Homo sapiens 61.0 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444567&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196673 440706812 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907376 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35) SPKWRLBKVPRPMT-UHFFFAOYSA-N 444569 US10662186, Compound 88::US10988476, Compound I-88 Cyclin-dependent kinase 7 Homo sapiens 95.9 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444569&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196688 440706814 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907380 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-9-8-19-17-38(12-7-11-37(5)6)13-10-23(19)34-25/h8-9,14-16H,7,10-13,17H2,1-6H3,(H,32,34,35,36) UVMVCEDKKHGTIW-UHFFFAOYSA-N 444571 US10662186, Compound 90::US10988476, Compound I-90 Cyclin-dependent kinase 7 Homo sapiens 36.5 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444571&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196721 440706816 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907384 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36) AKDZNPFQMDRCMU-UHFFFAOYSA-N 444573 US10662186, Compound 92::US10988476, Compound I-92 Cyclin-dependent kinase 7 Homo sapiens 50.1 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444573&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196689 440706818 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907388 CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1 PBDNNWWYSHCMCH-OAQYLSRUSA-N 444574 US10662186, Compound 93::US10988476, Compound I-93 Cyclin-dependent kinase 7 Homo sapiens 147 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444574&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196700 440706819 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907392 CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1 PBDNNWWYSHCMCH-NRFANRHFSA-N 444575 US10662186, Compound 94::US10988476, Compound I-94 Cyclin-dependent kinase 7 Homo sapiens 66.2 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444575&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196726 440706820 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907396 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H34F2N8/c1-18-33-28-22(30)14-20(15-25(28)39(18)21-6-4-5-7-21)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(2)3)11-10-24(19)34-26/h8-9,14-16,21H,4-7,10-13,17H2,1-3H3,(H,32,34,35,36) CZQMPFCNIINMMC-UHFFFAOYSA-N 444578 US10662186, Compound 98 Cyclin-dependent kinase 7 Homo sapiens 670 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444578&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196675 440706823 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907400 C[C@@H]1NCCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc12 InChI=1S/C25H27F2N7/c1-13-16-6-7-21(31-19(16)8-9-28-13)32-24-29-12-18(27)22(33-24)15-10-17(26)23-20(11-15)34(14(2)30-23)25(3,4)5/h6-7,10-13,28H,8-9H2,1-5H3,(H,29,31,32,33)/t13-/m0/s1 YRUAMADPOZOPBF-ZDUSSCGKSA-N 444579 US10662186, Compound 101::US10662186, Compound 104 Cyclin-dependent kinase 7 Homo sapiens 57.0 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444579&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196693 440706824 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907404 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 7 Homo sapiens 99.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907408 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 7 Homo sapiens 105 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907412 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1CCN(C)C InChI=1S/C29H36F2N8/c1-17-12-23-19(16-38(17)11-10-37(6)7)8-9-25(34-23)35-28-32-15-22(31)26(36-28)20-13-21(30)27-24(14-20)39(18(2)33-27)29(3,4)5/h8-9,13-15,17H,10-12,16H2,1-7H3,(H,32,34,35,36)/t17-/m1/s1 XKPZMRRASYJBKC-QGZVFWFLSA-N 444589 US10662186, Compound 112::US10662186, Compound 114 Cyclin-dependent kinase 7 Homo sapiens 195 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444589&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196716 440706831 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907415 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)12-20(13-24(27)38(17)15-18-4-5-18)26-22(30)14-31-28(35-26)34-25-7-6-19-16-37(11-10-36(2)3)9-8-23(19)33-25/h6-7,12-14,18H,4-5,8-11,15-16H2,1-3H3,(H,31,33,34,35) IUYLNMPIDQAYSG-UHFFFAOYSA-N 444591 US10662186, Compound 126::US10988476, Compound I-126 Cyclin-dependent kinase 7 Homo sapiens 1182 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444591&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196705 440706832 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51252772 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 7 Homo sapiens 300 ChEMBL 10.1016/j.ejmech.2019.03.064 10.7270/Q27M0C84 30978559 Poratti, M; Marzaro, G University of Padova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51252787 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 800 ChEMBL 10.1016/j.ejmech.2019.03.064 10.7270/Q27M0C84 30978559 Poratti, M; Marzaro, G University of Padova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907418 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 7 Homo sapiens 779 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907422 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m0/s1 LQHMJVOJVOLFTJ-FQEVSTJZSA-N 444593 US10662186, Compound 129 Cyclin-dependent kinase 7 Homo sapiens 53.4 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444593&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196707 440706833 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907426 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C29H34F2N8O/c1-17-34-27-21(30)11-19(12-24(27)39(17)29(2,3)4)26-22(31)14-33-28(37-26)36-25-6-5-18-15-38(9-7-23(18)35-25)16-20-13-32-8-10-40-20/h5-6,11-12,14,20,32H,7-10,13,15-16H2,1-4H3,(H,33,35,36,37)/t20-/m1/s1 LQHMJVOJVOLFTJ-HXUWFJFHSA-N 444594 US10662186, Compound 130 Cyclin-dependent kinase 7 Homo sapiens 109 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444594&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196712 440706834 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907430 CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1 DSMBDRWDECFDNR-NRFANRHFSA-N 444595 US10662186, Compound 131::US10988476, Compound I-131 Cyclin-dependent kinase 7 Homo sapiens 124 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444595&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196723 440706835 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907434 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-15-31-25-19(27)11-17(12-22(25)36(15)18-4-5-18)24-20(28)13-30-26(34-24)33-23-6-3-16-14-35(10-8-29-2)9-7-21(16)32-23/h3,6,11-13,18,29H,4-5,7-10,14H2,1-2H3,(H,30,32,33,34) JRGMQQCQWFMKLA-UHFFFAOYSA-N 444605 US10662186, Compound 142::US10988476, Compound I-142 Cyclin-dependent kinase 7 Homo sapiens 315 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444605&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196895 440706844 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907438 CN1CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)CC1 InChI=1S/C31H39F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-41(9-8-25(21)36-27)15-14-40-12-10-39(5)11-13-40/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) RHWIDIZNQRAAIU-UHFFFAOYSA-N 444607 US10662186, Compound 154::US10988476, Compound I-154 Cyclin-dependent kinase 7 Homo sapiens 181 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444607&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196899 440706846 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907442 CN(CCO)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8O/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-40/h6-7,14-16,40H,8-13,17H2,1-5H3,(H,32,34,35,36) GIOKUJORFDKSSG-UHFFFAOYSA-N 444609 US10662186, Compound 157::US10988476, Compound I-157 Cyclin-dependent kinase 7 Homo sapiens 215 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444609&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196902 440706848 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907446 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C27H32F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2,3)4)24-20(29)14-31-26(35-24)34-23-7-6-17-15-36(11-9-30-5)10-8-21(17)33-23/h6-7,12-14,30H,8-11,15H2,1-5H3,(H,31,33,34,35) NCAQSQYHTSCOCV-UHFFFAOYSA-N 444613 US10662186, Compound 176::US10988476, Compound I-176 Cyclin-dependent kinase 7 Homo sapiens 149 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444613&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196747 440706852 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907450 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34) IWSDTEGBQVXXON-UHFFFAOYSA-N 444620 US10662186, Compound 202::US10988476, Compound I-202 Cyclin-dependent kinase 7 Homo sapiens 160 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444620&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196757 440706859 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907454 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2)7-8-27)24-20(29)14-31-26(35-24)34-23-5-4-17-15-36(11-9-30-3)10-6-21(17)33-23/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,33,34,35) SAKHMWHBWMDUMO-UHFFFAOYSA-N 444621 US10662186, Compound 203::US10988476, Compound I-203 Cyclin-dependent kinase 7 Homo sapiens 250 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196758 440706860 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907457 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H23F2N7/c1-12(2)32-13(3)28-22-16(24)8-15(9-19(22)32)21-17(25)11-27-23(31-21)30-20-5-4-14-10-26-7-6-18(14)29-20/h4-5,8-9,11-12,26H,6-7,10H2,1-3H3,(H,27,29,30,31) HFKMNAUFISJBSK-UHFFFAOYSA-N 444486 US10662186, Compound 13::US10662186, Compound comparative A::US10988476, comparative example A Cyclin-dependent kinase 7 Homo sapiens 326 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444486&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693642 440706734 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907460 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-24-17(26)8-16(9-20(24)34)23-18(27)10-28-25(32-23)31-21-5-4-15-11-33(22(36)12-35)7-6-19(15)30-21/h4-5,8-10,13,35H,6-7,11-12H2,1-3H3,(H,28,30,31,32) HLOKDQHOCMHLLI-UHFFFAOYSA-N 50458035 CHEMBL4213219::US10662186, Compound comparative B::US10988476, comparative example B Cyclin-dependent kinase 7 Homo sapiens 5367 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458035&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118700794 433925300 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907463 COCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7O/c1-15(2)35-16(3)30-25-19(27)11-18(12-22(25)35)24-20(28)13-29-26(33-24)32-23-6-5-17-14-34(9-10-36-4)8-7-21(17)31-23/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,29,31,32,33) ROMAHJZEHBXJSU-UHFFFAOYSA-N 50458046 CHEMBL4213756::US10662186, Compound comparative C::US10988476, comparative example C Cyclin-dependent kinase 7 Homo sapiens 1094 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458046&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693641 433925311 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 907466 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCO)CCc3n2)ncc1F InChI=1S/C25H27F2N7O/c1-14(2)34-15(3)29-24-18(26)10-17(11-21(24)34)23-19(27)12-28-25(32-23)31-22-5-4-16-13-33(8-9-35)7-6-20(16)30-22/h4-5,10-12,14,35H,6-9,13H2,1-3H3,(H,28,30,31,32) ZAPGHPQYYDYEQW-UHFFFAOYSA-N 444634 US10662186, Compound comparative E::US10988476, comparative example E Cyclin-dependent kinase 7 Homo sapiens 799 US Patent 10.7270/Q2GX4FKS aid1804432 US10662186 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444634&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693648 440706872 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51251923 C[C@@H](O)[C@H](C)Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-11(2)27-10-23-17-18(22-9-16-8-21-13(4)7-12(16)3)25-20(26-19(17)27)24-14(5)15(6)28/h7-8,10-11,14-15,28H,9H2,1-6H3,(H2,22,24,25,26)/t14-,15+/m0/s1 PFRMQZGBTCACGO-LSDHHAIUSA-N 50511931 CHEMBL4579344 Cyclin-dependent kinase 7 Homo sapiens 193 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155565350 440720513 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51235445 COC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cnn(C)c2)nc2ccc(CC#N)nc12 InChI=1S/C25H32N10O2/c1-33-16-19(15-27-33)30-24-31-21-8-5-18(9-10-26)28-22(21)23(32-24)29-17-3-6-20(7-4-17)34-11-13-35(14-12-34)25(36)37-2/h5,8,15-17,20H,3-4,6-7,9,11-14H2,1-2H3,(H2,29,30,31,32)/t17-,20- RPGMSHCJIWHISY-IRJFHVNHSA-N 50505743 CHEMBL4582624 Cyclin-dependent kinase 7 Homo sapiens 17000 ChEMBL 10.1021/acs.jmedchem.9b01346 10.7270/Q26W9FBQ 31622099 Degorce, SL; Anjum, R; Bloecher, A; Carbajo, RJ; Dillman, KS; Drew, L; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Rosen, A; Scott, JS; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505743&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search K1E 6RFJ 139582017 440714328 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51235451 COC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N InChI=1S/C21H26N6O2/c1-29-21(28)27-10-8-26(9-11-27)17-5-3-16(4-6-17)25-20-18-12-15(13-22)2-7-19(18)23-14-24-20/h2,7,12,14,16-17H,3-6,8-11H2,1H3,(H,23,24,25)/t16-,17- YCFRZMCRPHNZOC-QAQDUYKDSA-N 50505741 CHEMBL4455718 Cyclin-dependent kinase 7 Homo sapiens 3100 ChEMBL 10.1021/acs.jmedchem.9b01346 10.7270/Q26W9FBQ 31622099 Degorce, SL; Anjum, R; Bloecher, A; Carbajo, RJ; Dillman, KS; Drew, L; Halsall, CT; Lenz, EM; Lindsay, NA; Mayo, MF; Pink, JH; Robb, GR; Rosen, A; Scott, JS; Xue, Y AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505741&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search K1H 6RFI 139582016 440714326 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51271226 Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1 InChI=1S/C21H13Cl2N3O2S/c22-17-6-4-15(11-18(17)23)19(27)25-16-5-3-12-9-14(2-1-13(12)10-16)20(28)26-21-24-7-8-29-21/h1-11H,(H,25,27)(H,24,26,28) MRITYVDXXFOOAU-UHFFFAOYSA-N 50519158 CHEMBL4445812 Cyclin-dependent kinase 7 Homo sapiens 8020 ChEMBL 10.1021/acs.jmedchem.9b00353 10.7270/Q2X06BF7 31381325 Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Chengdu University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519158&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138911334 440727740 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51326363 Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F InChI=1S/C18H18ClF2N5OS/c1-9-11(12-7-24-26-8-10(19)6-23-16(12)26)5-14(28-9)17(27)25-15-13(22)3-2-4-18(15,20)21/h5-8,13,15H,2-4,22H2,1H3,(H,25,27)/t13-,15-/m1/s1 NGFGTMFVWSDFPS-UKRRQHHQSA-N 50536681 CHEMBL4552628 Cyclin-dependent kinase 7 Homo sapiens <10.0 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536681&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 89735655 440827505 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51326436 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)NCC(F)(F)F InChI=1S/C17H13F3N6OS/c1-25-6-12(4-23-25)11-3-21-15-13(5-24-26(15)7-11)10-2-14(28-8-10)16(27)22-9-17(18,19)20/h2-8H,9H2,1H3,(H,22,27) UEFCSGDOOJJXTN-UHFFFAOYSA-N 50536678 CHEMBL4550702 Cyclin-dependent kinase 7 Homo sapiens 53 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536678&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 59603829 440827502 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51326483 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 LYADGAGFYYXXIO-ZWKOTPCHSA-N 50536679 CHEMBL4568087 Cyclin-dependent kinase 7 Homo sapiens 4.1 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536679&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 59603842 440827503 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51326305 FC(F)(F)CNC(=O)c1cc(cs1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCCCC2)cc1 InChI=1S/C26H26F3N5O2S/c27-26(28,29)17-31-25(35)23-12-19(16-37-23)22-14-32-34-15-20(13-30-24(22)34)18-4-6-21(7-5-18)36-11-10-33-8-2-1-3-9-33/h4-7,12-16H,1-3,8-11,17H2,(H,31,35) QNABDSWBQJKBHK-UHFFFAOYSA-N 50536675 CHEMBL4569508 Cyclin-dependent kinase 7 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536675&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24759534 440827499 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51297396 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51297413 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-dependent kinase 7 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51297441 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17+/m0/s1 KRIWIRSMQRQYJG-DLBZAZTESA-N 50347388 CHEMBL1234833 Cyclin-dependent kinase 7 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347388&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NS9 3NS9 25125014 136354074 CHEMBL1234833 ZINC58655676 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292322 Clc1cnc(NC2CCCCC2)nc1-c1c[nH]c2cccnc12 InChI=1S/C17H18ClN5/c18-13-10-21-17(22-11-5-2-1-3-6-11)23-15(13)12-9-20-14-7-4-8-19-16(12)14/h4,7-11,20H,1-3,5-6H2,(H,21,22,23) NZDHMGOJDIRDGD-UHFFFAOYSA-N 50526791 CHEMBL4465061 Cyclin-dependent kinase 7 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526791&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155530843 440735373 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292326 CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)[nH]nc2C1(C)C)c1ccccc1 InChI=1S/C28H33N7O3/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37)/t22-/m1/s1 KPABJHHKKJIDGX-JOCHJYFZSA-N 50526795 CHEMBL4450322 Cyclin-dependent kinase 7 Homo sapiens >100 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121443990 440735377 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292328 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 7 Homo sapiens 925 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292333 CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29) LSGRZENCFIIHNV-UHFFFAOYSA-N 50526793 CHEMBL4562323 Cyclin-dependent kinase 7 Homo sapiens 0.130000 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526793&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search WZ8 78161839 440735375 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292336 CC(C)c1cnn2c(NCc3cccc4[nH]ncc34)nc(OC3CCCNC3)nc12 InChI=1S/C21H26N8O/c1-13(2)16-12-25-29-19(16)26-21(30-15-6-4-8-22-10-15)27-20(29)23-9-14-5-3-7-18-17(14)11-24-28-18/h3,5,7,11-13,15,22H,4,6,8-10H2,1-2H3,(H,24,28)(H,23,26,27) YUPKNRGPZOEEQC-UHFFFAOYSA-N 50526798 CHEMBL4552441 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526798&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78162193 440735380 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292338 CC(C)c1cnn2c(NCc3cccc4n(C)ncc34)nc(OC3CCCNC3)nc12 InChI=1S/C22H28N8O/c1-14(2)17-12-26-30-20(17)27-22(31-16-7-5-9-23-11-16)28-21(30)24-10-15-6-4-8-19-18(15)13-25-29(19)3/h4,6,8,12-14,16,23H,5,7,9-11H2,1-3H3,(H,24,27,28) DNQFOZGVJCKAAB-UHFFFAOYSA-N 50526799 CHEMBL4440386 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526799&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78162195 440735381 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292341 Clc1cnc(N[C@@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 InChI=1S/C17H18ClN5/c18-14-10-21-17(22-11-4-3-7-19-8-11)23-16(14)13-9-20-15-6-2-1-5-12(13)15/h1-2,5-6,9-11,19-20H,3-4,7-8H2,(H,21,22,23)/t11-/m1/s1 XWKQZYOSWGEGIH-LLVKDONJSA-N 50526800 CHEMBL4533453 Cyclin-dependent kinase 7 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526800&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134543905 440735382 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292343 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1n[nH]c2ccccc12 InChI=1S/C17H17F3N6/c18-17(19,20)12-9-22-16(23-10-4-3-7-21-8-10)24-15(12)14-11-5-1-2-6-13(11)25-26-14/h1-2,5-6,9-10,21H,3-4,7-8H2,(H,25,26)(H,22,23,24)/t10-/m0/s1 RSEOXWPUDYEWFU-JTQLQIEISA-N 50526801 CHEMBL4474655 Cyclin-dependent kinase 7 Homo sapiens <20 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526801&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155537111 440735383 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292346 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292350 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@H]1CCC[C@](C)(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C31H35ClN8O2/c1-31(39-30-35-19-24(32)28(38-30)23-18-34-25-10-5-4-9-22(23)25)14-6-8-20(16-31)37-29(42)26-13-12-21(17-33-26)36-27(41)11-7-15-40(2)3/h4-5,7,9-13,17-20,34H,6,8,14-16H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b11-7+/t20-,31+/m0/s1 RDQZKZSJJKFEAE-PSUMGLBBSA-N 50526802 CHEMBL4468921 Cyclin-dependent kinase 7 Homo sapiens >200 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526802&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155533514 440735384 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292351 CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3cccc(NC(=O)c4ccc(NC(=O)C=C)cc4)c3)n[nH]c2C1(C)C)c1ccccc1 InChI=1S/C34H38N8O3/c1-6-29(43)35-24-17-15-23(16-18-24)32(44)37-26-14-10-13-25(19-26)36-31-27-20-42(34(2,3)30(27)39-40-31)33(45)38-28(21-41(4)5)22-11-8-7-9-12-22/h6-19,28H,1,20-21H2,2-5H3,(H,35,43)(H,37,44)(H,38,45)(H2,36,39,40)/t28-/m1/s1 VBYGXNURPHQSPG-MUUNZHRXSA-N 50526803 CHEMBL4434871::US10870651, Compound 101 Cyclin-dependent kinase 7 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526803&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121444083 440735385 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292361 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292370 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292378 CN(C)CCCC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H30ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-5,7-10,12-15,17-19,33H,6,11,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38) TUERFPPIPKZNKE-UHFFFAOYSA-N 50526806 CHEMBL4303279 Cyclin-dependent kinase 7 Homo sapiens 194 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526806&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search V0G 6XD3 119081415 440735388 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292380 CC(C)c1cnn2c(NCc3ccccc3N(C)C)nc(OC3CCN(C)CC3)nc12 InChI=1S/C23H33N7O/c1-16(2)19-15-25-30-21(19)26-23(31-18-10-12-29(5)13-11-18)27-22(30)24-14-17-8-6-7-9-20(17)28(3)4/h6-9,15-16,18H,10-14H2,1-5H3,(H,24,26,27) JYPAWUMVEPMZMD-UHFFFAOYSA-N 50526792 CHEMBL4454044 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526792&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71731769 440735374 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292387 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+ FONRCZUZCHXWBD-VGOFMYFVSA-N 50526794 CHEMBL4303287::US10787436, Compound I-18 Cyclin-dependent kinase 7 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526794&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78357763 440735376 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292391 Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 InChI=1S/C17H18ClN5/c18-14-10-21-17(22-11-4-3-7-19-8-11)23-16(14)13-9-20-15-6-2-1-5-12(13)15/h1-2,5-6,9-11,19-20H,3-4,7-8H2,(H,21,22,23)/t11-/m0/s1 XWKQZYOSWGEGIH-NSHDSACASA-N 50526790 CHEMBL4555799 Cyclin-dependent kinase 7 Homo sapiens <20 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526790&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155557337 440735372 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292392 CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3ccc(NC(=O)c4ccc(NC(=O)C=C)cc4)cc3)n[nH]c2C1(C)C)c1ccccc1 InChI=1S/C34H38N8O3/c1-6-29(43)35-24-14-12-23(13-15-24)32(44)37-26-18-16-25(17-19-26)36-31-27-20-42(34(2,3)30(27)39-40-31)33(45)38-28(21-41(4)5)22-10-8-7-9-11-22/h6-19,28H,1,20-21H2,2-5H3,(H,35,43)(H,37,44)(H,38,45)(H2,36,39,40)/t28-/m1/s1 AVLOXJCCPGBYDS-MUUNZHRXSA-N 50526807 CHEMBL4467048::US10870651, Compound 102 Cyclin-dependent kinase 7 Homo sapiens <100 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526807&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124134260 440735389 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51292393 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 480 ChEMBL 10.1016/j.ejmech.2019.111641 10.7270/Q24X5C86 31514062 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Tianjin University of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333110 CC[C@H](CO)Nc1cc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C20H27N5O/c1-4-16(13-26)23-18-10-19(21-11-15-8-6-5-7-9-15)25-20(24-18)17(12-22-25)14(2)3/h5-10,12,14,16,21,26H,4,11,13H2,1-3H3,(H,23,24)/t16-/m1/s1 DPQCCKVYNVNRCN-MRXNPFEDSA-N 50539707 CHEMBL4636757 Cyclin-dependent kinase 7 Homo sapiens 70 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539707&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25124680 442141270 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333111 CC(C)c1cnn2c(NCc3ccccc3F)cc(NCCCCCCN)nc12 InChI=1S/C22H31FN6/c1-16(2)18-15-27-29-21(26-14-17-9-5-6-10-19(17)23)13-20(28-22(18)29)25-12-8-4-3-7-11-24/h5-6,9-10,13,15-16,26H,3-4,7-8,11-12,14,24H2,1-2H3,(H,25,28) DMPMAUSQDWOMRL-UHFFFAOYSA-N 50539708 CHEMBL4638833 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539708&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 59534272 442141271 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333112 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@H](CO)CCCCCCc3cncnc3)nc12 InChI=1S/C28H37N7O/c1-21(2)25-18-32-35-27(31-17-22-10-7-5-8-11-22)14-26(34-28(25)35)33-24(19-36)13-9-4-3-6-12-23-15-29-20-30-16-23/h5,7-8,10-11,14-16,18,20-21,24,31,36H,3-4,6,9,12-13,17,19H2,1-2H3,(H,33,34)/t24-/m0/s1 MJHBAWMQTNXWKG-DEOSSOPVSA-N 50539709 CHEMBL4649721 Cyclin-dependent kinase 7 Homo sapiens 20 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539709&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156021858 442141272 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333113 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@H]3CNC[C@H]3O)nc12 InChI=1S/C20H26N6O/c1-13(2)15-10-23-26-19(22-9-14-6-4-3-5-7-14)8-18(25-20(15)26)24-16-11-21-12-17(16)27/h3-8,10,13,16-17,21-22,27H,9,11-12H2,1-2H3,(H,24,25)/t16-,17+/m0/s1 SMVTWEKPNPYGQX-DLBZAZTESA-N 50539710 CHEMBL4637408 Cyclin-dependent kinase 7 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539710&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118329676 442141273 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333114 CC(C)c1cnn2c(NCc3ccccc3)cc(NCC3CCNCC3)nc12 InChI=1S/C22H30N6/c1-16(2)19-15-26-28-21(25-14-17-6-4-3-5-7-17)12-20(27-22(19)28)24-13-18-8-10-23-11-9-18/h3-7,12,15-16,18,23,25H,8-11,13-14H2,1-2H3,(H,24,27) JKCBZAYPKOXUKH-UHFFFAOYSA-N 50526805 CHEMBL4519886 Cyclin-dependent kinase 7 Homo sapiens 310 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526805&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118329761 440735387 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333115 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCCC[C@@H]3O)nc12 InChI=1S/C23H31N5O/c1-16(2)19-15-26-28-22(25-13-17-8-4-3-5-9-17)12-21(27-23(19)28)24-14-18-10-6-7-11-20(18)29/h3-5,8-9,12,15-16,18,20,25,29H,6-7,10-11,13-14H2,1-2H3,(H,24,27)/t18-,20+/m1/s1 FEWLFECITKFLDY-QUCCMNQESA-N 50526796 CHEMBL4472515 Cyclin-dependent kinase 7 Homo sapiens 687 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526796&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118329760 440735378 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333116 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCCN)nc12 InChI=1S/C23H34N6/c1-18(2)20-17-27-29-22(26-16-19-11-7-6-8-12-19)15-21(28-23(20)29)25-14-10-5-3-4-9-13-24/h6-8,11-12,15,17-18,26H,3-5,9-10,13-14,16,24H2,1-2H3,(H,25,28) YNSKNIDAACFBJU-UHFFFAOYSA-N 50539711 CHEMBL4637421 Cyclin-dependent kinase 7 Homo sapiens 654 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539711&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25123364 442141274 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333117 CC(C)c1cnn2c(NCc3ccccc3F)cc(NCCCCCCCN)nc12 InChI=1S/C23H33FN6/c1-17(2)19-16-28-30-22(27-15-18-10-6-7-11-20(18)24)14-21(29-23(19)30)26-13-9-5-3-4-8-12-25/h6-7,10-11,14,16-17,27H,3-5,8-9,12-13,15,25H2,1-2H3,(H,26,29) LKMQQJWCSQJWGN-UHFFFAOYSA-N 50539712 CHEMBL4639779 Cyclin-dependent kinase 7 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539712&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25123694 442141275 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333118 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)CCCCCN)nc12 InChI=1S/C23H34N6O/c1-17(2)20-15-26-29-22(25-14-18-9-5-3-6-10-18)13-21(28-23(20)29)27-19(16-30)11-7-4-8-12-24/h3,5-6,9-10,13,15,17,19,25,30H,4,7-8,11-12,14,16,24H2,1-2H3,(H,27,28)/t19-/m1/s1 FUNKDCBNXPEVIP-LJQANCHMSA-N 50539713 CHEMBL4646646 Cyclin-dependent kinase 7 Homo sapiens 320 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539713&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 59534284 442141276 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333119 CC(C)c1cnn2c(NCc3ccccc3F)cc(N[C@@H](CO)CCCCCN)nc12 InChI=1S/C23H33FN6O/c1-16(2)19-14-27-30-22(26-13-17-8-5-6-10-20(17)24)12-21(29-23(19)30)28-18(15-31)9-4-3-7-11-25/h5-6,8,10,12,14,16,18,26,31H,3-4,7,9,11,13,15,25H2,1-2H3,(H,28,29)/t18-/m1/s1 ZEKWUYMSRXCIGE-GOSISDBHSA-N 50539714 CHEMBL4633156 Cyclin-dependent kinase 7 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539714&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 59534278 442141277 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333120 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@@H]3C[C@@H](O)CN3)nc12 InChI=1S/C21H28N6O/c1-14(2)18-13-25-27-20(24-10-15-6-4-3-5-7-15)9-19(26-21(18)27)23-11-16-8-17(28)12-22-16/h3-7,9,13-14,16-17,22,24,28H,8,10-12H2,1-2H3,(H,23,26)/t16-,17+/m0/s1 GANCMNWNJFMYQC-DLBZAZTESA-N 50539715 CHEMBL4635439 Cyclin-dependent kinase 7 Homo sapiens 59 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539715&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118329734 442141278 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333121 CO[C@H]1CN[C@H](CNc2cc(NCc3ccccc3)n3ncc(C(C)C)c3n2)C1 InChI=1S/C22H30N6O/c1-15(2)19-14-26-28-21(25-11-16-7-5-4-6-8-16)10-20(27-22(19)28)24-12-17-9-18(29-3)13-23-17/h4-8,10,14-15,17-18,23,25H,9,11-13H2,1-3H3,(H,24,27)/t17-,18+/m0/s1 XJHDRCOXVVOGNQ-ZWKOTPCHSA-N 50539716 CHEMBL4632793 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539716&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118329744 442141279 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333122 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H]3CCNC[C@H]3O)nc12 InChI=1S/C21H28N6O/c1-14(2)16-12-24-27-20(23-11-15-6-4-3-5-7-15)10-19(26-21(16)27)25-17-8-9-22-13-18(17)28/h3-7,10,12,14,17-18,22-23,28H,8-9,11,13H2,1-2H3,(H,25,26)/t17-,18-/m1/s1 FBEPFTDQWOUNNC-QZTJIDSGSA-N 50539717 CHEMBL4646538 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156019441 442141280 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333123 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@]3(O)CCNC[C@H]3O)nc12 InChI=1S/C21H28N6O2/c1-14(2)16-12-24-27-19(23-11-15-6-4-3-5-7-15)10-18(25-20(16)27)26-21(29)8-9-22-13-17(21)28/h3-7,10,12,14,17,22-23,28-29H,8-9,11,13H2,1-2H3,(H,25,26)/t17-,21+/m1/s1 MPYUSOZKKCEWKM-UTKZUKDTSA-N 50539718 CHEMBL4643708 Cyclin-dependent kinase 7 Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539718&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156017928 442141281 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333124 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-dependent kinase 7 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333131 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@@H](O)CO)nc12 InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17-/m0/s1 KRIWIRSMQRQYJG-IRXDYDNUSA-N 50539719 CHEMBL4644434 Cyclin-dependent kinase 7 Homo sapiens 250 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539719&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25125015 442141282 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333133 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333140 CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)c1ccc(NC(=O)C=C)cc1)c3)n2 InChI=1S/C33H32N6O3/c1-3-31(40)35-26-12-10-24(11-13-26)32(41)36-27-18-23-19-28(21-27)37-33-34-15-14-30(38-33)25-8-7-9-29(20-25)42-17-6-4-5-16-39(2)22-23/h3-5,7-15,18-21H,1,6,16-17,22H2,2H3,(H,35,40)(H,36,41)(H,34,37,38)/b5-4+ PVRJKFUTSFKLDZ-SNAWJCMRSA-N 50539720 CHEMBL4648392 Cyclin-dependent kinase 7 Homo sapiens <15 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539720&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122550796 442141283 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333141 CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cc(C1)cc(NC(=O)c1ccc(NC(=O)C=C)cc1)c3)n2 InChI=1S/C33H32N6O3/c1-3-31(40)35-26-12-10-24(11-13-26)32(41)36-27-18-23-19-28(21-27)37-33-34-15-14-30(38-33)25-8-7-9-29(20-25)42-17-6-4-5-16-39(2)22-23/h3-5,7-15,18-21H,1,6,16-17,22H2,2H3,(H,35,40)(H,36,41)(H,34,37,38)/b5-4+ PVRJKFUTSFKLDZ-SNAWJCMRSA-N 50539720 CHEMBL4648392 Cyclin-dependent kinase 7 Homo sapiens <1.000000 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539720&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 122550796 442141283 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333142 CC(C)c1cnn2c(NC3CCN(CC3)C(=O)O[C@H]3CCN(C3)C(=O)\C=C\CN(C)C)cc(C)nc12 InChI=1S/C26H39N7O3/c1-18(2)22-16-27-33-23(15-19(3)28-25(22)33)29-20-8-12-31(13-9-20)26(35)36-21-10-14-32(17-21)24(34)7-6-11-30(4)5/h6-7,15-16,18,20-21,29H,8-14,17H2,1-5H3/b7-6+/t21-/m0/s1 GRDAHPJRLCTJNA-BXKJMJEDSA-N 50539721 CHEMBL4635959 Cyclin-dependent kinase 7 Homo sapiens 148 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539721&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138608760 442141284 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333155 CC(C)c1cnn2c(NCc3ccccc3N(C)C)nc(OC3CCN(C)CC3)nc12 InChI=1S/C23H33N7O/c1-16(2)19-15-25-30-21(19)26-23(31-18-10-12-29(5)13-11-18)27-22(30)24-14-17-8-6-7-9-20(17)28(3)4/h6-9,15-16,18H,10-14H2,1-5H3,(H,24,26,27) JYPAWUMVEPMZMD-UHFFFAOYSA-N 50526792 CHEMBL4454044 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526792&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71731769 440735374 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333157 CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(O[C@H]3CCCNC3)nc12 InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29)/t18-/m0/s1 LSGRZENCFIIHNV-SFHVURJKSA-N 50539722 CHEMBL4644572 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50539722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50539722&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124663976 442141285 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333160 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 510 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51333184 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1 RUBYHLPRZRMTJO-MOVYNIQHSA-N 50528813 CHEMBL4163879 Cyclin-dependent kinase 7 Homo sapiens 158 ChEMBL 10.1021/acs.jmedchem.9b01985 10.7270/Q2C82DT8 32150405 Diab, S; Yu, M; Wang, S Lebanese American University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528813&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025540 440737395 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51334320 CCn1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO 50540077 CHEMBL4649135 Cyclin-dependent kinase 7 Homo sapiens >28000 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540077&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 131953498 442141640 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51334328 Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1F InChI=1S/C18H25FN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24)/t12-,13- YSPIHUWHLMNFOV-JOCQHMNTSA-N 50540079 CHEMBL4632717 Cyclin-dependent kinase 7 Homo sapiens 0.310000 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540079&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134812748 442141642 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51334331 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50540080 CHEMBL4648857 Cyclin-dependent kinase 7 Homo sapiens 8500 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540080&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033814 442141643 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51334337 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24) OWXORKPNCHJYOF-UHFFFAOYSA-N 50235342 CHEMBL319467::NU-6102 Cyclin-dependent kinase 7 Homo sapiens 4400 ChEMBL 10.1016/j.ejmech.2019.01.003 10.7270/Q2C53QDZ 30639897 Cheng, W; Yang, Z; Wang, S; Li, Y; Wei, H; Tian, X; Kan, Q The First Affiliated Hospital of Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235342&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 4SP 5M57,6BSS,2C6O,4EOK,4EOR,1H1S,5LQF,2IW8,2IW9 4566 384991216 CHEMBL319467 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986838 Nc1ccc(cc1)C(=O)NC12CC3CC(C1)CC(C3)(C2)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 475931 US10865206, Compound 100 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290980 442075998 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986839 Nc1ccc(cc1)C(=O)NC1CC(O)CC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 475935 US10865206, Compound 101 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475935&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121284488 442076002 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986840 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395707 4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 102::US10865206, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395707&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033991 405265786 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986841 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C2CC2)c(n1)-c1c[nH]c2ccccc12 395708 4-amino-N-((1S,3R)-3-(5-cyclopropyl-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 103::US10865206, Compound 103 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395708&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025488 405265787 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986842 Nc1ccc(cc1)C(=O)NC12CC(C1)(CCC2)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C26H25ClN6O/c27-20-13-30-24(31-22(20)19-12-29-21-5-2-1-4-18(19)21)33-26-11-3-10-25(14-26,15-26)32-23(34)16-6-8-17(28)9-7-16/h1-2,4-9,12-13,29H,3,10-11,14-15,28H2,(H,32,34)(H,30,31,33) ZTXOOBWQLUXXDV-UHFFFAOYSA-N 395709 4-amino-N-(5-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)bicyclo[3.1.1]heptan-1-yl)benzamide::US10308648, Compound 104::US10865206, Compound 104 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395709&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025260 405265788 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986843 CN(C)CCCC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395710 N-((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)-4-(4-(dimethylamino)butanamido)benzamide ::US10308648, Compound 105::US10865206, Compound 105 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395710&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290981 405265789 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986844 Nc1ccc(NC(=O)[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 395711 (1S,3R)—N-(4-aminophenyl)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexanecarboxamide::US10308648, Compound 106::US10865206, Compound 106 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395711&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118034014 405265790 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986845 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(C#N)c(n1)-c1c[nH]c2ccccc12 395712 4-amino-N-((1S,3R)-3-(5-cyano-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 107::US10865206, Compound 107 Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395712&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025265 405265791 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986846 Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1cccnc1 InChI=1S/C22H23ClN6O/c23-19-13-26-22(29-20(19)15-3-2-10-25-12-15)28-18-5-1-4-17(11-18)27-21(30)14-6-8-16(24)9-7-14/h2-3,6-10,12-13,17-18H,1,4-5,11,24H2,(H,27,30)(H,26,28,29)/t17-,18+/m0/s1 CDRVASIYWVWJCA-ZWKOTPCHSA-N 395713 4-amino-N-((1S,3R)-3-(5-chloro-4-(pyridin-3-yl)pyrimidin-2-ylamino)cyclohexyl)benzamide::US10308648, Compound 108::US10865206, Compound 108 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395713&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118034031 405265792 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986847 Nc1ccc(cc1)S(=O)(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395714 US10308648, Compound 109::US10865206, Compound 109 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395714&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025250 405265793 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986848 Nc1ccc(cc1)C(=O)NC1CC(F)CC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 475948 US10865206, Compound 110 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475948&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033993 442076015 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986849 Nc1ccc(cc1F)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395716 4-amino-N-(1S,3R)-3-(5-chloro-4-(4H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-3-fluorobenzamide::US10308648, Compound 111::US10865206, Compound 111 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395716&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025493 405265795 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986850 Nc1ccc(C(=O)N[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 395717 4-amino-N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)cyclohexyl)-2-fluorobenzamide::US10308648, Compound 112::US10865206, Compound 112 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025248 405265796 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986851 NC(=O)C(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 395718 N1-(4-(((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)carbamoyl)phenyl)oxalamide ::US10308648, Compound 113::US10865206, Compound 113 Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=395718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=395718&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121290979 405265797 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 986852 CC(C)(C)OC(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 475952 US10865206, Compound 114 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2736V0F aid1805104 US10865206 Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Syros Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475952&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025197 442076019 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994906 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)OC(C)(C)C 478430 2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide::US10894786, Comp. No 1 Cyclin-dependent kinase 7 Homo sapiens 3300 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478430&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027186 442138029 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994909 C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C 478485 (S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 2 Cyclin-dependent kinase 7 Homo sapiens 2290 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478485&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558754 442138084 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994911 CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)C=C 478800 2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)-3-methylbutanamide::US10894786, Comp. No 3 Cyclin-dependent kinase 7 Homo sapiens 506 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478800&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558809 442138395 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994914 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C 478281 2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide::US10894786, Comp. No 4 Cyclin-dependent kinase 7 Homo sapiens 1710 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478281&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558801 442137880 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994917 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C 478326 2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide (Isomer-2 of compound-4)::US10894786, Comp. No 5::US10894786, Comp. No 6 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478326&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558801 442137925 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994920 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C 478326 2-(1''-acryloyl-1'',2'',3'',6''-tetrahydro-[2,4''-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide (Isomer-2 of compound-4)::US10894786, Comp. No 5::US10894786, Comp. No 6 Cyclin-dependent kinase 7 Homo sapiens 1300 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478326&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558801 442137925 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994922 CC(C)C(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C=C 478893 2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)-3-methylbutanamide::US10894786, Comp. No 7 Cyclin-dependent kinase 7 Homo sapiens 744 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478893&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558790 442138488 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994927 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCCN(CC1)C(=O)C=C 478491 2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl)phenyl)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 9 Cyclin-dependent kinase 7 Homo sapiens 6585 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478491&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558746 442138090 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994930 C[C@@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C 478327 N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-oxopropan-2- yl)phenyl)cyclohexyl)acrylamide::US10894786, Comp. No 10 Cyclin-dependent kinase 7 Homo sapiens 5492 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478327&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027183 442137926 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994933 C[C@H](C(=O)Nc1cc(n[nH]1)C1CC1)c1ccc(cc1)C1CCC(CC1)NC(=O)C=C 478666 N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-oxopropan-2- yl)phenyl)cyclohexyl)acrylamide::US10894786, Comp. No 11 Cyclin-dependent kinase 7 Homo sapiens 3646 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478666&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027190 442138261 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994936 C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1CCN(CC1)C(=O)C=C 478328 (S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 12 Cyclin-dependent kinase 7 Homo sapiens 2830 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478328&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558792 442137927 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994939 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCN(CC1)C(=O)C=C 478329 2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 13 Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478329&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558755 442137928 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994944 C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CN(C)C 478350 (S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4-(dimethylamino)but-2- enoyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)propanamide::US10894786, Comp. No 15 Cyclin-dependent kinase 7 Homo sapiens 621 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478350&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558793 442137949 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994949 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C 478931 2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 17 Cyclin-dependent kinase 7 Homo sapiens 7960 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027193 442138526 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994952 C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)N1CCN(CC1)C(=O)C=C 478758 2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 18 Cyclin-dependent kinase 7 Homo sapiens 2322 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478758&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027191 442138353 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994956 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)N1CCN(CC1)C(=O)C=C 478354 2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 20 Cyclin-dependent kinase 7 Homo sapiens 2090 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478354&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558784 442137953 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994963 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCCN(C1)C(=O)C=C 478934 2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide::US10894786, Comp. No 35 Cyclin-dependent kinase 7 Homo sapiens 153 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478934&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558778 442138528 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994970 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C 478936 2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide::US10894786, Comp. No 38 Cyclin-dependent kinase 7 Homo sapiens 1010 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478936&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558738 442138529 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994977 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1CCCN(C1)C(=O)C=C 478939 2-(6-(1-acryloylpiperidin-3-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H-pyrazol-3- yl)propanamide::US10894786, Comp. No 41 Cyclin-dependent kinase 7 Homo sapiens 3510 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478939&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558803 442138532 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994980 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCCN(C2)C(=O)C=C)c(F)c1 478940 2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3-fluorophenyl)-N-(5- cyclopropyl-1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 42 Cyclin-dependent kinase 7 Homo sapiens 440 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478940&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558737 442138533 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994985 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1 478942 2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-N-(5- cyclopropyl-1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 44::US10894786, Comp. No 45 Cyclin-dependent kinase 7 Homo sapiens 880 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478942&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558766 442138535 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994988 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(C2=CCN(CC2)C(=O)C=C)c(F)c1 478942 2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-N-(5- cyclopropyl-1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 44::US10894786, Comp. No 45 Cyclin-dependent kinase 7 Homo sapiens 5760 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478942&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558766 442138535 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994997 C=CC(=O)N1CCC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1 InChI=1S/C21H23N5O2/c1-2-21(28)26-9-3-4-16(13-26)17-8-5-14(12-22-17)10-20(27)23-19-11-18(24-25-19)15-6-7-15/h2,4-5,8,11-12,15H,1,3,6-7,9-10,13H2,(H2,23,24,25,27) XRMFYNTXRQPSMN-UHFFFAOYSA-N 478947 2-(1'-acryloyl-1',2',5',6'-tetrahydro-[2,3'-bipyridin]-5-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)acetamide::US10894786, Comp. No 49 Cyclin-dependent kinase 7 Homo sapiens 1730 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478947&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558775 442138538 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 994999 CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(CC1)C(=O)C#C[Si](C)(C)C 478948 N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(1'-propioloyl-1',2',3',6'-tetrahydro-[2,4'- bipyridin]-5-yl)propanamide::US10894786, Comp. No 50 Cyclin-dependent kinase 7 Homo sapiens 12.0 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478948&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156027195 442138539 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 995002 CC#CC(=O)N1CCC(=CC1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1 478949 2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-5-yl)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 51 Cyclin-dependent kinase 7 Homo sapiens 1692 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478949&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558760 442138540 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 995005 CC#CC(=O)N1CCC=C(C1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1 478950 2-(1'-(but-2-ynoyl)-1',2',5',6'-tetrahydro-[2,3'-bipyridin]-5-yl)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 52 Cyclin-dependent kinase 7 Homo sapiens 2190 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478950&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558789 442138541 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 995008 C=CC(=O)N1CC=C(C1)c1ccc(CC(=O)Nc2cc([nH]n2)C2CC2)cn1 InChI=1S/C20H21N5O2/c1-2-20(27)25-8-7-15(12-25)16-6-3-13(11-21-16)9-19(26)22-18-10-17(23-24-18)14-4-5-14/h2-3,6-7,10-11,14H,1,4-5,8-9,12H2,(H2,22,23,24,26) KEWSSFSLZFTZRZ-UHFFFAOYSA-N 478951 2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)acetamide::US10894786, Comp. No 53 Cyclin-dependent kinase 7 Homo sapiens 7790 US Patent 10.7270/Q2K35XRV aid1805194 US10894786 Poddutoori, R; Samajdar, S; Mukherjee, S Aurigene Discovery Technologies Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=478951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=478951&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139558769 442138542 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028702 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-dependent kinase 7 Homo sapiens 667 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028705 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN(C)C)ncc1F InChI=1S/C27H30F2N8O/c1-15(2)37-16(3)31-26-19(28)10-18(11-22(26)37)25-20(29)12-30-27(34-25)33-23-7-6-17-13-36(9-8-21(17)32-23)24(38)14-35(4)5/h6-7,10-12,15H,8-9,13-14H2,1-5H3,(H,30,32,33,34) SSVSKCKWUAPYHI-UHFFFAOYSA-N 50458034 CHEMBL4212532::US10662186, Compound 5::US10988476, Compound I-5 Cyclin-dependent kinase 7 Homo sapiens 913 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458034&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114516 433925299 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028708 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C)CCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13(2)33-14(3)28-23-17(25)9-16(10-20(23)33)22-18(26)11-27-24(31-22)30-21-6-5-15-12-32(4)8-7-19(15)29-21/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,27,29,30,31) AXTGGTFVALFVDO-UHFFFAOYSA-N 444482 US10662186, Compound 8::US10988476, Compound I-8 Cyclin-dependent kinase 7 Homo sapiens 393 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444482&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196664 440706730 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028711 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CCO)ncc1F InChI=1S/C26H27F2N7O2/c1-14(2)35-15(3)30-25-18(27)10-17(11-21(25)35)24-19(28)12-29-26(33-24)32-22-5-4-16-13-34(23(37)7-9-36)8-6-20(16)31-22/h4-5,10-12,14,36H,6-9,13H2,1-3H3,(H,29,31,32,33) JDIAYVMOUUKPNK-UHFFFAOYSA-N 444483 US10662186, Compound 9::US10988476, Compound I-9 Cyclin-dependent kinase 7 Homo sapiens 13157 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444483&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196659 440706731 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028714 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCCC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8O/c1-17-33-28-21(30)12-19(13-24(28)39(17)20-6-4-5-7-20)27-22(31)14-32-29(36-27)35-25-9-8-18-15-38(11-10-23(18)34-25)26(40)16-37(2)3/h8-9,12-14,20H,4-7,10-11,15-16H2,1-3H3,(H,32,34,35,36) ZFXSUJXETQKSKI-UHFFFAOYSA-N 444493 US10662186, Compound 22::US10988476, Compound I-22 Cyclin-dependent kinase 7 Homo sapiens 1045 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444493&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196666 440706741 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028717 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCN(C)CC2)ncc1F InChI=1S/C30H35F2N9O/c1-18(2)41-19(3)34-29-22(31)13-21(14-25(29)41)28-23(32)15-33-30(37-28)36-26-6-5-20-16-40(8-7-24(20)35-26)27(42)17-39-11-9-38(4)10-12-39/h5-6,13-15,18H,7-12,16-17H2,1-4H3,(H,33,35,36,37) KZZDDXBCJROTIP-UHFFFAOYSA-N 50458051 CHEMBL4206061::US10988476, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 801 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458051&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114324 433925316 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028720 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CN2CCOCC2)ncc1F InChI=1S/C29H32F2N8O2/c1-17(2)39-18(3)33-28-21(30)12-20(13-24(28)39)27-22(31)14-32-29(36-27)35-25-5-4-19-15-38(7-6-23(19)34-25)26(40)16-37-8-10-41-11-9-37/h4-5,12-14,17H,6-11,15-16H2,1-3H3,(H,32,34,35,36) HXKORJQOSCRLJP-UHFFFAOYSA-N 444495 US10662186, Compound 24::US10988476, Compound I-24 Cyclin-dependent kinase 7 Homo sapiens 2893 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444495&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114319 440706743 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028723 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C(C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35) SSIOYGMEKCPFAV-UHFFFAOYSA-N 444496 US10662186, Compound 25::US10988476, Compound I-25 Cyclin-dependent kinase 7 Homo sapiens 978 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444496&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196667 440706744 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028726 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-31-26-19(28)10-17(11-22(26)37(15)18-5-6-18)25-20(29)12-30-27(34-25)33-23-7-4-16-13-36(9-8-21(16)32-23)24(38)14-35(2)3/h4,7,10-12,18H,5-6,8-9,13-14H2,1-3H3,(H,30,32,33,34) OIQZLVBXHSEFQP-UHFFFAOYSA-N 444501 US10662186, Compound 29::US10662186, Compound 37::US10662186, Compound 64::US10988476, Compound I-29 Cyclin-dependent kinase 7 Homo sapiens 574 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444501&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196847 440706749 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028729 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C=C)ncc1F InChI=1S/C26H25F2N7O/c1-5-23(36)34-9-8-20-16(13-34)6-7-22(31-20)32-26-29-12-19(28)24(33-26)17-10-18(27)25-21(11-17)35(14(2)3)15(4)30-25/h5-7,10-12,14H,1,8-9,13H2,2-4H3,(H,29,31,32,33) SOHOEERULHWXJB-UHFFFAOYSA-N 444516 US10662186, Compound 38::US10988476, Compound I-38 Cyclin-dependent kinase 7 Homo sapiens >30000 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444516&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124114603 440706763 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028732 CN(C)CCOC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O2/c1-16-32-26-20(29)12-18(13-23(26)38(16)19-5-6-19)25-21(30)14-31-27(35-25)34-24-7-4-17-15-37(9-8-22(17)33-24)28(39)40-11-10-36(2)3/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,31,33,34,35) XLZHLULRODUOPS-UHFFFAOYSA-N 444525 US10662186, Compound 46::US10988476, Compound I-46 Cyclin-dependent kinase 7 Homo sapiens 1280 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444525&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196818 440706772 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028735 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 7 Homo sapiens 563 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028738 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)NCCO)ncc1F InChI=1S/C26H26F2N8O2/c1-14-31-24-18(27)10-16(11-21(24)36(14)17-3-4-17)23-19(28)12-30-25(34-23)33-22-5-2-15-13-35(8-6-20(15)32-22)26(38)29-7-9-37/h2,5,10-12,17,37H,3-4,6-9,13H2,1H3,(H,29,38)(H,30,32,33,34) XTSFMAFWRLGELC-UHFFFAOYSA-N 444530 US10662186, Compound 50::US10988476, Compound I-50 Cyclin-dependent kinase 7 Homo sapiens 718 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444530&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196796 440706777 C04080 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028741 CNCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C27H28F2N8O/c1-15-32-26-19(28)10-17(11-22(26)37(15)18-4-3-5-18)25-20(29)12-31-27(35-25)34-23-7-6-16-14-36(24(38)13-30-2)9-8-21(16)33-23/h6-7,10-12,18,30H,3-5,8-9,13-14H2,1-2H3,(H,31,33,34,35) UTDIUAOBXDHROL-UHFFFAOYSA-N 444531 US10662186, Compound 51::US10988476, Compound I-51 Cyclin-dependent kinase 7 Homo sapiens 1153 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444531&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196799 440706778 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028745 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-31-26-20(28)12-18(13-23(26)37(16)19-5-6-19)25-21(29)14-30-27(34-25)33-24-7-4-17-15-36(11-10-35(2)3)9-8-22(17)32-24/h4,7,12-14,19H,5-6,8-11,15H2,1-3H3,(H,30,32,33,34) UZUCFTPPULEGQO-UHFFFAOYSA-N 444532 US10662186, Compound 52::US10988476, Compound I-52 Cyclin-dependent kinase 7 Homo sapiens 223 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444532&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196740 440706779 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028748 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CCC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)11-18(12-23(27)38(16)19-5-4-6-19)26-21(30)13-31-28(35-26)34-24-8-7-17-14-37(10-9-22(17)33-24)25(39)15-36(2)3/h7-8,11-13,19H,4-6,9-10,14-15H2,1-3H3,(H,31,33,34,35) KPCVCNZJVUSNOC-UHFFFAOYSA-N 493977 US10988476, Compound I-54 Cyclin-dependent kinase 7 Homo sapiens 1818 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493977&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196800 447112501 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028754 CN(C)CC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-16-32-27-20(29)10-19(11-23(27)38(16)13-17-4-5-17)26-21(30)12-31-28(35-26)34-24-7-6-18-14-37(9-8-22(18)33-24)25(39)15-36(2)3/h6-7,10-12,17H,4-5,8-9,13-15H2,1-3H3,(H,31,33,34,35) FEBXDTFBHZJUJT-UHFFFAOYSA-N 444540 US10662186, Compound 60::US10988476, Compound I-60 Cyclin-dependent kinase 7 Homo sapiens 1195 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444540&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196821 440706787 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028757 CN(C)CCN(C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H33F2N9O/c1-17-33-27-21(30)13-19(14-24(27)40(17)20-6-7-20)26-22(31)15-32-28(36-26)35-25-8-5-18-16-39(10-9-23(18)34-25)29(41)38(4)12-11-37(2)3/h5,8,13-15,20H,6-7,9-12,16H2,1-4H3,(H,32,34,35,36) IVKYJVDFJKEXIH-UHFFFAOYSA-N 444541 US10662186, Compound 61::US10988476, Compound I-61 Cyclin-dependent kinase 7 Homo sapiens 710 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444541&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196824 440706788 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028760 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H](C)N(C)C)ncc1F InChI=1S/C28H32F2N8O/c1-15(2)38-17(4)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-28(35-25)34-24-8-7-18-14-37(10-9-22(18)33-24)27(39)16(3)36(5)6/h7-8,11-13,15-16H,9-10,14H2,1-6H3,(H,31,33,34,35)/t16-/m1/s1 SSIOYGMEKCPFAV-MRXNPFEDSA-N 444542 US10662186, Compound 62::US10988476, Compound I-62 Cyclin-dependent kinase 7 Homo sapiens 2819 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444542&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196777 440706789 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028764 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Cyclin-dependent kinase 7 Homo sapiens 261 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028767 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)C2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36) QXBRBWDRQIISAT-UHFFFAOYSA-N 444545 US10662186, Compound 65::US10662186, Compound 67::US10988476, Compound I-65 Cyclin-dependent kinase 7 Homo sapiens 1076 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444545&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196850 440706791 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028770 Cc1nc2c(F)cc(cc2n1C1CC1)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)[C@@H]2CCCN2)ncc1F InChI=1S/C28H28F2N8O/c1-15-33-26-19(29)11-17(12-23(26)38(15)18-5-6-18)25-20(30)13-32-28(36-25)35-24-7-4-16-14-37(10-8-21(16)34-24)27(39)22-3-2-9-31-22/h4,7,11-13,18,22,31H,2-3,5-6,8-10,14H2,1H3,(H,32,34,35,36)/t22-/m0/s1 QXBRBWDRQIISAT-QFIPXVFZSA-N 493985 US10988476, Compound I-67 Cyclin-dependent kinase 7 Homo sapiens 556 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493985&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196873 447112509 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028774 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C24H25F2N7/c1-13-29-22-16(25)9-15(10-19(22)33(13)24(2,3)4)21-17(26)12-28-23(32-21)31-20-6-5-14-11-27-8-7-18(14)30-20/h5-6,9-10,12,27H,7-8,11H2,1-4H3,(H,28,30,31,32) LIJUCWLALFXGCL-UHFFFAOYSA-N 444548 US10662186, Compound 68::US10988476, Compound I-68 Cyclin-dependent kinase 7 Homo sapiens 20.5 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444548&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196856 440706793 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028778 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C28H34F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2,3)4)25-21(30)15-31-27(35-25)34-24-8-7-18-16-37(12-11-36(5)6)10-9-22(18)33-24/h7-8,13-15H,9-12,16H2,1-6H3,(H,31,33,34,35) AKGTYSYXMRZPBV-UHFFFAOYSA-N 444549 US10662186, Compound 69::US10988476, Compound I-69 Cyclin-dependent kinase 7 Homo sapiens 129 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444549&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196857 440706794 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028782 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)13-19(14-24(27)38(17)20-6-7-20)26-22(30)15-31-28(35-26)34-25-8-5-18-16-37(11-4-10-36(2)3)12-9-23(18)33-25/h5,8,13-15,20H,4,6-7,9-12,16H2,1-3H3,(H,31,33,34,35) GYDXFTMHNUETBY-UHFFFAOYSA-N 444550 US10662186, Compound 70::US10988476, Compound I-70 Cyclin-dependent kinase 7 Homo sapiens 196 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444550&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196851 440706795 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028786 CN1CCC[C@@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m1/s1 DSMBDRWDECFDNR-OAQYLSRUSA-N 444555 US10662186, Compound 74::US10988476, Compound I-74 Cyclin-dependent kinase 7 Homo sapiens 104 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444555&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196858 440706800 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028790 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CC#CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H32F2N8/c1-18(2)39-19(3)33-28-22(30)14-21(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-20-17-38(13-10-24(20)34-26)12-7-6-11-37(4)5/h8-9,14-16,18H,10-13,17H2,1-5H3,(H,32,34,35,36) SUEYATVNHWMTSO-UHFFFAOYSA-N 444560 US10662186, Compound 79::US10988476, Compound I-79 Cyclin-dependent kinase 7 Homo sapiens 280 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444560&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196679 440706805 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028794 C[C@H](CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1)N(C)C InChI=1S/C28H32F2N8/c1-16(36(3)4)14-37-10-9-23-18(15-37)5-8-25(33-23)34-28-31-13-22(30)26(35-28)19-11-21(29)27-24(12-19)38(17(2)32-27)20-6-7-20/h5,8,11-13,16,20H,6-7,9-10,14-15H2,1-4H3,(H,31,33,34,35)/t16-/m1/s1 WIAMCDYCLOMHKF-MRXNPFEDSA-N 444561 US10662186, Compound 80::US10988476, Compound I-80 Cyclin-dependent kinase 7 Homo sapiens 147 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444561&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196724 440706806 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028798 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H27F2N7/c1-4-17(5-2)34-14(3)30-24-18(26)10-16(11-21(24)34)23-19(27)13-29-25(33-23)32-22-7-6-15-12-28-9-8-20(15)31-22/h6-7,10-11,13,17,28H,4-5,8-9,12H2,1-3H3,(H,29,31,32,33) YPMOBRWHNOTUIL-UHFFFAOYSA-N 444563 US10662186, Compound 82::US10988476, Compound I-82 Cyclin-dependent kinase 7 Homo sapiens 11.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444563&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196672 440706808 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028802 CCC(CC)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H36F2N8/c1-6-21(7-2)39-18(3)33-28-22(30)14-20(15-25(28)39)27-23(31)16-32-29(36-27)35-26-9-8-19-17-38(13-12-37(4)5)11-10-24(19)34-26/h8-9,14-16,21H,6-7,10-13,17H2,1-5H3,(H,32,34,35,36) POTKDJWRAMHALZ-UHFFFAOYSA-N 444564 US10662186, Compound 83::US10988476, Compound I-83 Cyclin-dependent kinase 7 Homo sapiens 38.1 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444564&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196685 440706809 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028806 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C25H25F2N7/c1-13(15-3-4-15)34-14(2)30-24-18(26)9-17(10-21(24)34)23-19(27)12-29-25(33-23)32-22-6-5-16-11-28-8-7-20(16)31-22/h5-6,9-10,12-13,15,28H,3-4,7-8,11H2,1-2H3,(H,29,31,32,33) ANELMUPUYRZVHZ-UHFFFAOYSA-N 444565 US10662186, Compound 84::US10988476, Compound I-84 Cyclin-dependent kinase 7 Homo sapiens 16.7 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444565&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196684 440706810 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028810 CC(C1CC1)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C29H34F2N8/c1-17(19-5-6-19)39-18(2)33-28-22(30)13-21(14-25(28)39)27-23(31)15-32-29(36-27)35-26-8-7-20-16-38(12-11-37(3)4)10-9-24(20)34-26/h7-8,13-15,17,19H,5-6,9-12,16H2,1-4H3,(H,32,34,35,36) VUKGJVXJRDQYFA-UHFFFAOYSA-N 444567 US10662186, Compound 86::US10988476, Compound I-86 Cyclin-dependent kinase 7 Homo sapiens 61.0 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444567&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196673 440706812 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028814 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-26-20(29)13-19(14-23(26)38(17)28(2)8-9-28)25-21(30)15-31-27(35-25)34-24-6-5-18-16-37(12-11-36(3)4)10-7-22(18)33-24/h5-6,13-15H,7-12,16H2,1-4H3,(H,31,33,34,35) SPKWRLBKVPRPMT-UHFFFAOYSA-N 444569 US10662186, Compound 88::US10988476, Compound I-88 Cyclin-dependent kinase 7 Homo sapiens 95.9 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444569&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196688 440706814 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028818 CN(C)CCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-9-8-19-17-38(12-7-11-37(5)6)13-10-23(19)34-25/h8-9,14-16H,7,10-13,17H2,1-6H3,(H,32,34,35,36) UVMVCEDKKHGTIW-UHFFFAOYSA-N 444571 US10662186, Compound 90::US10988476, Compound I-90 Cyclin-dependent kinase 7 Homo sapiens 36.5 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444571&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196721 440706816 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028822 CN(C)CCC(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H34F2N8O/c1-17-33-27-20(30)13-19(14-23(27)39(17)29(2,3)4)26-21(31)15-32-28(36-26)35-24-8-7-18-16-38(12-9-22(18)34-24)25(40)10-11-37(5)6/h7-8,13-15H,9-12,16H2,1-6H3,(H,32,34,35,36) AKDZNPFQMDRCMU-UHFFFAOYSA-N 444573 US10662186, Compound 92::US10988476, Compound I-92 Cyclin-dependent kinase 7 Homo sapiens 50.1 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444573&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196689 440706818 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028826 CN1CCO[C@@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m1/s1 PBDNNWWYSHCMCH-OAQYLSRUSA-N 444574 US10662186, Compound 93::US10988476, Compound I-93 Cyclin-dependent kinase 7 Homo sapiens 147 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444574&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196700 440706819 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028830 CN1CCO[C@H](CN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)C1 InChI=1S/C30H36F2N8O/c1-18-34-28-22(31)12-20(13-25(28)40(18)30(2,3)4)27-23(32)14-33-29(37-27)36-26-7-6-19-15-39(9-8-24(19)35-26)17-21-16-38(5)10-11-41-21/h6-7,12-14,21H,8-11,15-17H2,1-5H3,(H,33,35,36,37)/t21-/m0/s1 PBDNNWWYSHCMCH-NRFANRHFSA-N 444575 US10662186, Compound 94::US10988476, Compound I-94 Cyclin-dependent kinase 7 Homo sapiens 66.2 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444575&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196726 440706820 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028834 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN=C(N)N)CCc3n2)ncc1F InChI=1S/C26H30F2N10/c1-14(2)38-15(3)33-24-18(27)10-17(11-21(24)38)23-19(28)12-32-26(36-23)35-22-5-4-16-13-37(8-6-20(16)34-22)9-7-31-25(29)30/h4-5,10-12,14H,6-9,13H2,1-3H3,(H4,29,30,31)(H,32,34,35,36) FTFHCSWIOVPGGS-UHFFFAOYSA-N 444577 US10662186, Compound 97::US10988476, Compound I-98 Cyclin-dependent kinase 7 Homo sapiens 670 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444577&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196690 440706822 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028838 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)CB(O)O)CCc3n2)ncc1F InChI=1S/C27H33BF2N8O2/c1-16(2)38-17(3)32-26-20(29)11-19(12-23(26)38)25-21(30)13-31-27(35-25)34-24-6-5-18-14-37(8-7-22(18)33-24)10-9-36(4)15-28(39)40/h5-6,11-13,16,39-40H,7-10,14-15H2,1-4H3,(H,31,33,34,35) GNEARXSVRDSWKT-UHFFFAOYSA-N 494018 US10988476, Compound I-101 Cyclin-dependent kinase 7 Homo sapiens 57.0 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494018&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145763686 447112542 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028842 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 7 Homo sapiens 99.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028846 C[C@@H]1Cc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2CN1 InChI=1S/C25H27F2N7/c1-13-8-19-15(11-28-13)6-7-21(31-19)32-24-29-12-18(27)22(33-24)16-9-17(26)23-20(10-16)34(14(2)30-23)25(3,4)5/h6-7,9-10,12-13,28H,8,11H2,1-5H3,(H,29,31,32,33)/t13-/m1/s1 JKKUZTDMJDZHEB-CYBMUJFWSA-N 444586 US10662186, Compound 109::US10662186, Compound 111::US10988476, Compound I-111 Cyclin-dependent kinase 7 Homo sapiens 105 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444586&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196711 440706829 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028850 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCS(C)(=O)=NC#N)CCc3n2)ncc1F InChI=1S/C27H29F2N9OS/c1-16(2)38-17(3)33-26-20(28)11-19(12-23(26)38)25-21(29)13-31-27(36-25)35-24-6-5-18-14-37(8-7-22(18)34-24)9-10-40(4,39)32-15-30/h5-6,11-13,16H,7-10,14H2,1-4H3,(H,31,34,35,36) PEMNVVTZKGRLSX-UHFFFAOYSA-N 494029 US10988476, Compound I-114 Cyclin-dependent kinase 7 Homo sapiens 195 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494029&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196695 447112553 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028853 CN(C)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(CC5CC5)c4c3)ccc2C1 InChI=1S/C28H32F2N8/c1-17-32-27-21(29)12-20(13-24(27)38(17)15-18-4-5-18)26-22(30)14-31-28(35-26)34-25-7-6-19-16-37(11-10-36(2)3)9-8-23(19)33-25/h6-7,12-14,18H,4-5,8-11,15-16H2,1-3H3,(H,31,33,34,35) IUYLNMPIDQAYSG-UHFFFAOYSA-N 444591 US10662186, Compound 126::US10988476, Compound I-126 Cyclin-dependent kinase 7 Homo sapiens 1182 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444591&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196705 440706832 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028856 C[C@@H](N(C)C)C(=O)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C28H30F2N8O/c1-15(36(3)4)27(39)37-10-9-22-17(14-37)5-8-24(33-22)34-28-31-13-21(30)25(35-28)18-11-20(29)26-23(12-18)38(16(2)32-26)19-6-7-19/h5,8,11-13,15,19H,6-7,9-10,14H2,1-4H3,(H,31,33,34,35)/t15-/m1/s1 IIHKFIWSMAISST-OAHLLOKOSA-N 444526 US10662186, Compound 127::US10662186, Compound 47::US10988476, Compound I-127 Cyclin-dependent kinase 7 Homo sapiens 779 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444526&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196706 440706773 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028860 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C[C@@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C28H32F2N8O/c1-16(2)38-17(3)33-27-21(29)10-19(11-24(27)38)26-22(30)13-32-28(36-26)35-25-5-4-18-14-37(8-6-23(18)34-25)15-20-12-31-7-9-39-20/h4-5,10-11,13,16,20,31H,6-9,12,14-15H2,1-3H3,(H,32,34,35,36)/t20-/m0/s1 PUXKEKPYASIYGT-FQEVSTJZSA-N 494032 US10988476, Compound I-129 Cyclin-dependent kinase 7 Homo sapiens 53.4 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494032&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 154612573 447112556 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028864 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F InChI=1S/C28H32F2N8O/c1-16(2)38-17(3)33-27-21(29)10-19(11-24(27)38)26-22(30)13-32-28(36-26)35-25-5-4-18-14-37(8-6-23(18)34-25)15-20-12-31-7-9-39-20/h4-5,10-11,13,16,20,31H,6-9,12,14-15H2,1-3H3,(H,32,34,35,36)/t20-/m1/s1 PUXKEKPYASIYGT-HXUWFJFHSA-N 494033 US10988476, Compound I-130 Cyclin-dependent kinase 7 Homo sapiens 109 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=494033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=494033&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 154612566 447112557 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028868 CN1CCC[C@H]1CN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C29H32F2N8/c1-17-33-28-22(30)12-19(13-25(28)39(17)20-6-7-20)27-23(31)14-32-29(36-27)35-26-8-5-18-15-38(11-9-24(18)34-26)16-21-4-3-10-37(21)2/h5,8,12-14,20-21H,3-4,6-7,9-11,15-16H2,1-2H3,(H,32,34,35,36)/t21-/m0/s1 DSMBDRWDECFDNR-NRFANRHFSA-N 444595 US10662186, Compound 131::US10988476, Compound I-131 Cyclin-dependent kinase 7 Homo sapiens 124 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444595&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196723 440706835 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028872 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C5CC5)c4c3)ccc2C1 InChI=1S/C26H28F2N8/c1-15-31-25-19(27)11-17(12-22(25)36(15)18-4-5-18)24-20(28)13-30-26(34-24)33-23-6-3-16-14-35(10-8-29-2)9-7-21(16)32-23/h3,6,11-13,18,29H,4-5,7-10,14H2,1-2H3,(H,30,32,33,34) JRGMQQCQWFMKLA-UHFFFAOYSA-N 444605 US10662186, Compound 142::US10988476, Compound I-142 Cyclin-dependent kinase 7 Homo sapiens 315 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444605&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196895 440706844 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028876 CN1CCN(CCN2CCc3nc(Nc4ncc(F)c(n4)-c4cc(F)c5nc(C)n(c5c4)C(C)(C)C)ccc3C2)CC1 InChI=1S/C31H39F2N9/c1-20-35-29-23(32)16-22(17-26(29)42(20)31(2,3)4)28-24(33)18-34-30(38-28)37-27-7-6-21-19-41(9-8-25(21)36-27)15-14-40-12-10-39(5)11-13-40/h6-7,16-18H,8-15,19H2,1-5H3,(H,34,36,37,38) RHWIDIZNQRAAIU-UHFFFAOYSA-N 444607 US10662186, Compound 154::US10988476, Compound I-154 Cyclin-dependent kinase 7 Homo sapiens 181 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444607&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196899 440706846 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028880 CN(CCO)CCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C29H36F2N8O/c1-18-33-27-21(30)14-20(15-24(27)39(18)29(2,3)4)26-22(31)16-32-28(36-26)35-25-7-6-19-17-38(9-8-23(19)34-25)11-10-37(5)12-13-40/h6-7,14-16,40H,8-13,17H2,1-5H3,(H,32,34,35,36) GIOKUJORFDKSSG-UHFFFAOYSA-N 444609 US10662186, Compound 157::US10988476, Compound I-157 Cyclin-dependent kinase 7 Homo sapiens 215 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444609&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196902 440706848 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028884 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C(C)(C)C)ccc2C1 InChI=1S/C27H32F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2,3)4)24-20(29)14-31-26(35-24)34-23-7-6-17-15-36(11-9-30-5)10-8-21(17)33-23/h6-7,12-14,30H,8-11,15H2,1-5H3,(H,31,33,34,35) NCAQSQYHTSCOCV-UHFFFAOYSA-N 444613 US10662186, Compound 176::US10988476, Compound I-176 Cyclin-dependent kinase 7 Homo sapiens 149 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444613&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196747 440706852 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028888 Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN)CCc3n2)ncc1F InChI=1S/C26H30F2N8/c1-15-31-24-18(27)11-17(12-21(24)36(15)26(2,3)4)23-19(28)13-30-25(34-23)33-22-6-5-16-14-35(10-8-29)9-7-20(16)32-22/h5-6,11-13H,7-10,14,29H2,1-4H3,(H,30,32,33,34) IWSDTEGBQVXXON-UHFFFAOYSA-N 444620 US10662186, Compound 202::US10988476, Compound I-202 Cyclin-dependent kinase 7 Homo sapiens 160 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444620&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196757 440706859 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028892 CNCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(c4c3)C3(C)CC3)ccc2C1 InChI=1S/C27H30F2N8/c1-16-32-25-19(28)12-18(13-22(25)37(16)27(2)7-8-27)24-20(29)14-31-26(35-24)34-23-5-4-17-15-36(11-9-30-3)10-6-21(17)33-23/h4-5,12-14,30H,6-11,15H2,1-3H3,(H,31,33,34,35) SAKHMWHBWMDUMO-UHFFFAOYSA-N 444621 US10662186, Compound 203::US10988476, Compound I-203 Cyclin-dependent kinase 7 Homo sapiens 250 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 130196758 440706860 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028895 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3n2)ncc1F InChI=1S/C23H23F2N7/c1-12(2)32-13(3)28-22-16(24)8-15(9-19(22)32)21-17(25)11-27-23(31-21)30-20-5-4-14-10-26-7-6-18(14)29-20/h4-5,8-9,11-12,26H,6-7,10H2,1-3H3,(H,27,29,30,31) HFKMNAUFISJBSK-UHFFFAOYSA-N 444486 US10662186, Compound 13::US10662186, Compound comparative A::US10988476, comparative example A Cyclin-dependent kinase 7 Homo sapiens 326 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444486&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693642 440706734 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028898 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCc3n2)C(=O)CO)ncc1F InChI=1S/C25H25F2N7O2/c1-13(2)34-14(3)29-24-17(26)8-16(9-20(24)34)23-18(27)10-28-25(32-23)31-21-5-4-15-11-33(22(36)12-35)7-6-19(15)30-21/h4-5,8-10,13,35H,6-7,11-12H2,1-3H3,(H,28,30,31,32) HLOKDQHOCMHLLI-UHFFFAOYSA-N 50458035 CHEMBL4213219::US10662186, Compound comparative B::US10988476, comparative example B Cyclin-dependent kinase 7 Homo sapiens 5367 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458035&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118700794 433925300 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028901 COCCN1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1 InChI=1S/C26H29F2N7O/c1-15(2)35-16(3)30-25-19(27)11-18(12-22(25)35)24-20(28)13-29-26(33-24)32-23-6-5-17-14-34(9-10-36-4)8-7-21(17)31-23/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,29,31,32,33) ROMAHJZEHBXJSU-UHFFFAOYSA-N 50458046 CHEMBL4213756::US10662186, Compound comparative C::US10988476, comparative example C Cyclin-dependent kinase 7 Homo sapiens 1094 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458046&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693641 433925311 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1028904 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCO)CCc3n2)ncc1F InChI=1S/C25H27F2N7O/c1-14(2)34-15(3)29-24-18(26)10-17(11-21(24)34)23-19(27)12-28-25(32-23)31-22-5-4-16-13-33(8-9-35)7-6-20(16)30-22/h4-5,10-12,14,35H,6-9,13H2,1-3H3,(H,28,30,31,32) ZAPGHPQYYDYEQW-UHFFFAOYSA-N 444634 US10662186, Compound comparative E::US10988476, comparative example E Cyclin-dependent kinase 7 Homo sapiens 799 US Patent 10.7270/Q2PR8047 aid1805496 US10988476 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444634&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118693648 440706872 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51366801 NC(=O)c1sc(nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1)-c1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H32FN5O3S/c29-22-7-3-19(4-8-22)17-34-13-10-18(11-14-34)2-1-15-37-27-24(25(30)35)38-28(33-27)21-9-12-31-23(16-21)32-26(36)20-5-6-20/h3-4,7-9,12,16,18,20H,1-2,5-6,10-11,13-15,17H2,(H2,30,35)(H,31,32,36) LQLBWZJHRARWDB-UHFFFAOYSA-N 50552452 CHEMBL4747992 Cyclin-dependent kinase 7 Homo sapiens >300 ChEMBL 10.1016/j.bmc.2020.115940 10.7270/Q20K2D6W 33340937 Jiang, X; Wang, Y; Liu, C; Xing, C; Wang, Y; Lyu, W; Wang, S; Li, Q; Chen, T; Chen, Y; Feng, F; Liu, W; Sun, H China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552452&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156165678 461682792 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368320 C#Cc1nc(Nc2ccccc2)nc2[nH]cnc12 InChI=1S/C13H9N5/c1-2-10-11-12(15-8-14-11)18-13(17-10)16-9-6-4-3-5-7-9/h1,3-8H,(H2,14,15,16,17,18) PRKFJWMFXNJCLC-UHFFFAOYSA-N 50235350 CHEMBL4094562 Cyclin-dependent kinase 7 Homo sapiens 76700 ChEMBL 10.1039/d0md00074d 10.7270/Q2P272RV 33479670 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235350&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137653554 384991224 CHEMBL4094562 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368321 NS(=O)(=O)c1ccc(Nc2nc(C#C)c3nc[nH]c3n2)cc1 InChI=1S/C13H10N6O2S/c1-2-10-11-12(16-7-15-11)19-13(18-10)17-8-3-5-9(6-4-8)22(14,20)21/h1,3-7H,(H2,14,20,21)(H2,15,16,17,18,19) IOGIUPJAOMXLRJ-UHFFFAOYSA-N 50235361 CHEMBL4074015 Cyclin-dependent kinase 7 Homo sapiens 36100 ChEMBL 10.1039/d0md00074d 10.7270/Q2P272RV 33479670 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235361&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137640457 384991235 CHEMBL4074015 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368980 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368981 C[C@H](CO)Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Br InChI=1S/C13H16BrN5O3S/c1-8(7-20)17-12-11(14)6-16-13(19-12)18-9-2-4-10(5-3-9)23(15,21)22/h2-6,8,20H,7H2,1H3,(H2,15,21,22)(H2,16,17,18,19)/t8-/m1/s1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 50553480 CHEMBL4741442 Cyclin-dependent kinase 7 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553480&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3I6 4BGH 58890996 461692248 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368982 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-dependent kinase 7 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368983 COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)ncc1Cl InChI=1S/C21H23ClFN3O3/c1-12(27)25-15-5-3-4-13(8-15)21(28)26-20-10-17(18(22)11-24-20)16-7-6-14(23)9-19(16)29-2/h6-7,9-11,13,15H,3-5,8H2,1-2H3,(H,25,27)(H,24,26,28)/t13-,15+/m0/s1 YWKHYOGNLAAFGK-DZGCQCFKSA-N 50553479 CHEMBL4755256 Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553479&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156492051 461692247 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368984 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368985 CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C20H28N6O/c1-5-16(14(4)27)23-20-24-18(21-11-15-9-7-6-8-10-15)17-19(25-20)26(12-22-17)13(2)3/h6-10,12-14,16,27H,5,11H2,1-4H3,(H2,21,23,24,25)/t14-,16+/m1/s1 CVIBDXQYFNZNMA-ZBFHGGJFSA-N 50553481 CHEMBL4764173 Cyclin-dependent kinase 7 Homo sapiens 193 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553481&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10292487 461692249 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51368986 CN1C\C=C\CCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2 InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+ VXBAJLGYBMTJCY-NSCUHMNNSA-N 50363196 CHEMBL1944698 Cyclin-dependent kinase 7 Homo sapiens 37 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363196&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16739650 136967258 CHEMBL1944698 ZINC68251500 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51369043 CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1 InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1 AVIWDYSJSPOOAR-LSDHHAIUSA-N 50528817 CHEMBL4462530::US10717746, Example 14 Cyclin-dependent kinase 7 Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528817&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search Q6E 6Z45 124155204 440737399 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51369056 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 167699 US9073922, 186::US9796708, Example 186 Cyclin-dependent kinase 7 Homo sapiens >1360 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167699&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90414175 312321544 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51369057 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid Cyclin-dependent kinase 7 Homo sapiens >320 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354126&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047858 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51369072 Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C18H25ClN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24)/t12-,13- RVZJFCNYSSUDCU-JOCQHMNTSA-N 50553499 CHEMBL4754493 Cyclin-dependent kinase 7 Homo sapiens 1.3 ChEMBL 10.1021/acs.jmedchem.0c00744 10.7270/Q2FB56K3 32866383 Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553499&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126558497 461692267 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51512777 COc1ccc2c(c1)[nH]c1c(C)nccc21 InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 BXNJHAXVSOCGBA-UHFFFAOYSA-N 100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.7270/Q2GF0ZQF 33528252 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100152&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search HRM 7X9D,5Y86,2Z5X,3ANR,2Z5Y 5280953 252663240 28121 DB07919 C06538 ZINC18847046 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51400668 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 3.2 ChEMBL 10.1021/acs.jmedchem.0c00766 10.7270/Q2GX4G9M 33135887 Myers, SH; Ortega, JA; Cavalli, A Istituto Italiano di Tecnologia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51398764 FC(F)(F)c1cc(NC(=O)Nc2ccc3N(c4ccncc4)C(=O)c4cccnc4Oc3c2)ccc1Cl InChI=1S/C25H15ClF3N5O3/c26-19-5-3-14(12-18(19)25(27,28)29)32-24(36)33-15-4-6-20-21(13-15)37-22-17(2-1-9-31-22)23(35)34(20)16-7-10-30-11-8-16/h1-13H,(H2,32,33,36) NQHGDUGVQSAKOR-UHFFFAOYSA-N 50565105 CHEMBL4792974 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112443 10.7270/Q2TF023Q 32599324 Martínez-González, S; García, AB; Albarrán, MI; Cebriá, A; Amezquita-Alves, A; García-Campos, FJ; Martínez-Gago, J; Martínez-Torrecuadrada, J; Muñoz, IG; Blanco-Aparicio, C; Pastor, J Spanish National Cancer Research Centre (CNIO) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565105&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NZ8 6TPA 154815588 461685443 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430686 Cc1n[nH]c2ccc(cc12)-c1cncc(NC(CO)c2ccccc2)n1 50578001 CHEMBL4855785 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578001&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164609699 471054124 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430687 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccccc2)n1 50578008 CHEMBL4856767 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578008&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164611914 471054131 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430688 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2ccc(F)cc2)n1 50578010 CHEMBL4860265 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578010&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164618094 471054133 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430689 Cc1n[nH]c2ccc(cc12)-c1cncc(N[C@@H](CO)c2cccc(F)c2)n1 50578014 CHEMBL4872952 Cyclin-dependent kinase 7 Homo sapiens 496 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578014&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164619500 471054137 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430690 Cc1n[nH]c2ccc(cc12)-c1cncc(NC2CCCC(O)C2)n1 50578019 CHEMBL4863726 Cyclin-dependent kinase 7 Homo sapiens 322 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578019&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164622173 471054142 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430691 Cc1n[nH]c2ncc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578021 CHEMBL4857229 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578021&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164614171 471054144 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430692 Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1Cl 50578022 CHEMBL4876497 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578022&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162640599 471054145 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51430693 COC[C@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m0/s1 XWQVQSXLXAXOPJ-ACRUOGEOSA-N 50553495 CHEMBL4786559 Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/acs.jmedchem.1c01148 10.7270/Q2154MVT 34477384 Han, X; Song, N; Saidahmatov, A; Wang, P; Wang, Y; Hu, X; Kan, W; Zhu, W; Gao, L; Zeng, M; Wang, Y; Li, C; Li, J; Liu, H; Zhou, Y; Wang, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553495&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 68276369 461692263 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51466672 C[C@H]1C[C@@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H19N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13H,8-11H2,1H3/b19-14-/t12-,13+/m0/s1 VHRVZYTVMBOFAO-NDQRQRNDSA-N 50591706 CHEMBL5184492 Cyclin-dependent kinase 7 Homo sapiens 660000 ChEMBL 10.7270/Q2XW4PS2 34998058 Jiang, X; Wu, K; Bai, R; Zhang, P; Zhang, Y Central South University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591706&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168282162 482602558 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488919 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Cyclin-dependent kinase 7 Homo sapiens 171 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488922 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 3.2 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488923 CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3cccc(NC(=O)c4ccc(NC(=O)C=C)cc4)c3)n[nH]c2C1(C)C)c1ccccc1 InChI=1S/C34H38N8O3/c1-6-29(43)35-24-17-15-23(16-18-24)32(44)37-26-14-10-13-25(19-26)36-31-27-20-42(34(2,3)30(27)39-40-31)33(45)38-28(21-41(4)5)22-11-8-7-9-12-22/h6-19,28H,1,20-21H2,2-5H3,(H,35,43)(H,37,44)(H,38,45)(H2,36,39,40)/t28-/m1/s1 VBYGXNURPHQSPG-MUUNZHRXSA-N 50526803 CHEMBL4434871::US10870651, Compound 101 Cyclin-dependent kinase 7 Homo sapiens 7.6 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526803&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121444083 440735385 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488924 CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)[nH]nc2C1(C)C)c1ccccc1 InChI=1S/C28H33N7O3/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37)/t22-/m1/s1 KPABJHHKKJIDGX-JOCHJYFZSA-N 50526795 CHEMBL4450322 Cyclin-dependent kinase 7 Homo sapiens 9.7 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121443990 440735377 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488925 Nc1nc(N[C@H]2CC3CCC2C3)sc1C(=O)c1ccccc1[N+]([O-])=O InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1 JRNXAQINDCOHGS-CBINBANVSA-N 50600027 CHEMBL5202522 Cyclin-dependent kinase 7 Homo sapiens 555 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50600027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50600027&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135248847 482610879 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488926 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50540080 CHEMBL4648857 Cyclin-dependent kinase 7 Homo sapiens 8500 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540080&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118033814 442141643 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488927 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488928 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+ FONRCZUZCHXWBD-VGOFMYFVSA-N 50526794 CHEMBL4303287::US10787436, Compound I-18 Cyclin-dependent kinase 7 Homo sapiens 14 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526794&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78357763 440735376 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488956 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51488997 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C31H35ClN8O2/c1-31(39-29(42)26-13-12-21(17-33-26)36-27(41)11-7-15-40(2)3)14-6-8-20(16-31)37-30-35-19-24(32)28(38-30)23-18-34-25-10-5-4-9-22(23)25/h4-5,7,9-13,17-20,34H,6,8,14-16H2,1-3H3,(H,36,41)(H,39,42)(H,35,37,38)/b11-7+/t20-,31+/m1/s1 SCJNYBYSTCRPAO-LXBQGUBHSA-N 50528812 CHEMBL4582951 Cyclin-dependent kinase 7 Homo sapiens 84000 ChEMBL 10.7270/Q2BV7MPD 35235745 Xie, Z; Hou, S; Yang, X; Duan, Y; Han, J; Wang, Q; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528812&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118426108 440737394 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51478347 CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29) LSGRZENCFIIHNV-UHFFFAOYSA-N 50526793 CHEMBL4562323 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526793&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search WZ8 78161839 440735375 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51462466 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 240 ChEMBL 10.7270/Q2DF6W53 36561076 Gai, C; Harnor, SJ; Zhang, S; Cano, C; Zhuang, C; Zhao, Q College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51462467 CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)[nH]nc2C1(C)C)c1ccccc1 InChI=1S/C28H33N7O3/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37)/t22-/m1/s1 KPABJHHKKJIDGX-JOCHJYFZSA-N 50526795 CHEMBL4450322 Cyclin-dependent kinase 7 Homo sapiens 54 ChEMBL 10.7270/Q2DF6W53 36561076 Gai, C; Harnor, SJ; Zhang, S; Cano, C; Zhuang, C; Zhao, Q College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121443990 440735377 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51478410 CC(C)c1[nH]n(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)nc(=O)c12 InChI=1S/C23H22Cl2N4O3/c1-13(2)20-19-22(29(28-20)21-16(24)4-3-5-17(21)25)26-18(27-23(19)31)12-14-6-8-15(9-7-14)32-11-10-30/h3-9,13,28,30H,10-12H2,1-2H3 VQNCIRRXQQTXEL-UHFFFAOYSA-N 50595929 CHEMBL5193007 Cyclin-dependent kinase 7 Homo sapiens 71 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595929&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135473382 482606781 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51478411 CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 InChI=1S/C23H28N8O/c1-16(2)19-15-27-31-21(19)28-23(32-18-8-5-10-24-14-18)29-22(31)25-13-17-7-3-4-9-20(17)30-12-6-11-26-30/h3-4,6-7,9,11-12,15-16,18,24H,5,8,10,13-14H2,1-2H3,(H,25,28,29) LSGRZENCFIIHNV-UHFFFAOYSA-N 50526793 CHEMBL4562323 Cyclin-dependent kinase 7 Homo sapiens <5.0 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526793&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search WZ8 78161839 440735375 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51461710 Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)cn1 InChI=1S/C19H15F3N4O2/c20-19(21,22)12-2-1-3-14(10-12)26-18(27)25-13-4-6-15(7-5-13)28-16-8-9-17(23)24-11-16/h1-11H,(H2,23,24)(H2,25,26,27) MBIXOXMOHXFUFZ-UHFFFAOYSA-N 50589846 CHEMBL5190752 Cyclin-dependent kinase 7 Homo sapiens 100 ChEMBL 10.7270/Q28W3J8D 36126227 Yan, YY; Zhang, XX; Xiao, Y; Shen, XB; Jian, YJ; Wang, YM; She, ZH; Liu, MM; Liu, XH Anhui Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589846&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 165412810 482600698 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51463331 CC(C)n1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO 50590456 CHEMBL5188909 Cyclin-dependent kinase 7 Homo sapiens >30000 ChEMBL 10.7270/Q28K7F2W 35868123 Lei, P; Zhang, J; Liao, P; Ren, C; Wang, J; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50590456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50590456&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134691746 482601308 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51463335 CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1 PIMQWRZWLQKKBJ-SFHVURJKSA-N 50139171 Dinaciclib::MK-7965::SCH-727965::US11643396, Example Dinaciclib Cyclin-dependent kinase 7 Homo sapiens 42 ChEMBL 10.7270/Q28K7F2W 35868123 Lei, P; Zhang, J; Liao, P; Ren, C; Wang, J; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50139171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50139171&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46926350 336952252 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51463336 Cn1cc(ccc1=O)-c1ccc(cc1)N(C1CCC(CC1)Nc1ccc(cn1)C#N)C(=O)NCc1ccccc1 InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40) HDJBGURZVALLMD-UHFFFAOYSA-N 50590457 CHEMBL5193291 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.7270/Q28K7F2W 35868123 Lei, P; Zhang, J; Liao, P; Ren, C; Wang, J; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50590457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50590457&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134813906 482601309 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51455672 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-dependent kinase 7 Homo sapiens 5.0 ChEMBL 10.7270/Q23X8BM3 33356242 Faisal, M; Kim, JH; Yoo, KH; Roh, EJ; Hong, SS; Lee, SH University of Science and Technology (UST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471943 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471944 CN(C)\C=C\CC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cc3ccccc3[nH]2)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)34-22-14-12-20(13-15-22)30(41)35-23-8-5-9-24(18-23)36-31-33-19-25(32)29(38-31)27-17-21-7-3-4-10-26(21)37-27/h3-10,12-19,37H,11H2,1-2H3,(H,34,40)(H,35,41)(H,33,36,38)/b16-6+ QPXVSBSNCYBNFT-OMCISZLKSA-N 50593925 CHEMBL5196685 Cyclin-dependent kinase 7 Homo sapiens 3.2 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593925&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168286783 482604777 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471946 CN(C)\C=C\CC(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50593926 CHEMBL5207274 Cyclin-dependent kinase 7 Homo sapiens 17 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593926&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168295697 482604778 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457406 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20FN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) UBVYPGDWOQOPMK-UHFFFAOYSA-N 167534 US9073922, 18::US9796708, Example 18 Cyclin-dependent kinase 7 Homo sapiens 990 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90412502 312321379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457407 COc1cc(ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1)C(=O)N1CCCC1 InChI=1S/C24H28N4O2/c1-30-22-14-17(24(29)28-12-2-3-13-28)4-5-19(22)18-8-11-26-23-20(18)15-21(27-23)16-6-9-25-10-7-16/h4-5,8,11,14-16,25H,2-3,6-7,9-10,12-13H2,1H3,(H,26,27) VBWQPLLCGUWXEE-UHFFFAOYSA-N 50588261 CHEMBL5170524 Cyclin-dependent kinase 7 Homo sapiens 300 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588261&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168270118 482599113 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457408 CC(C)n1cc(ccc1=O)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H31N5O2/c1-16(2)29-14-18(5-6-22(29)30)19-7-10-25-24-20(19)13-21(26-24)17-8-11-28(12-9-17)15-23(31)27(3)4/h5-7,10,13-14,16-17H,8-9,11-12,15H2,1-4H3,(H,25,26) HUUCUGRZFSMNOH-UHFFFAOYSA-N 50588263 CHEMBL5198038 Cyclin-dependent kinase 7 Homo sapiens 460 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588263&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168289339 482599115 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457409 CC(C)n1cc(ccc1=O)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCCCC2)CC1 InChI=1S/C27H35N5O2/c1-19(2)32-17-21(6-7-25(32)33)22-8-11-28-27-23(22)16-24(29-27)20-9-14-30(15-10-20)18-26(34)31-12-4-3-5-13-31/h6-8,11,16-17,19-20H,3-5,9-10,12-15,18H2,1-2H3,(H,28,29) GLYHKPNATCXTDU-UHFFFAOYSA-N 50588262 CHEMBL5197170 Cyclin-dependent kinase 7 Homo sapiens 400 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588262&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 163196243 482599114 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457410 CC(C)n1cc(ccc1=O)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCCC2)CC1 InChI=1S/C26H33N5O2/c1-18(2)31-16-20(5-6-24(31)32)21-7-10-27-26-22(21)15-23(28-26)19-8-13-29(14-9-19)17-25(33)30-11-3-4-12-30/h5-7,10,15-16,18-19H,3-4,8-9,11-14,17H2,1-2H3,(H,27,28) GNWQPICFCPORII-UHFFFAOYSA-N 50588264 CHEMBL5207871 Cyclin-dependent kinase 7 Homo sapiens 470 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588264&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168294347 482599116 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457428 COc1cc(F)ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1 InChI=1S/C19H20FN3O/c1-24-18-10-13(20)2-3-15(18)14-6-9-22-19-16(14)11-17(23-19)12-4-7-21-8-5-12/h2-3,6,9-12,21H,4-5,7-8H2,1H3,(H,22,23) UBVYPGDWOQOPMK-UHFFFAOYSA-N 167534 US9073922, 18::US9796708, Example 18 Cyclin-dependent kinase 7 Homo sapiens >30000 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167534&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90412502 312321379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457429 COc1cc(ccc1-c1ccnc2[nH]c(cc12)C1CCNCC1)C(=O)N1CCCC1 InChI=1S/C24H28N4O2/c1-30-22-14-17(24(29)28-12-2-3-13-28)4-5-19(22)18-8-11-26-23-20(18)15-21(27-23)16-6-9-25-10-7-16/h4-5,8,11,14-16,25H,2-3,6-7,9-10,12-13H2,1H3,(H,26,27) VBWQPLLCGUWXEE-UHFFFAOYSA-N 50588261 CHEMBL5170524 Cyclin-dependent kinase 7 Homo sapiens 14000 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588261&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168270118 482599113 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457430 CC(C)n1cc(ccc1=O)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCCCC2)CC1 InChI=1S/C27H35N5O2/c1-19(2)32-17-21(6-7-25(32)33)22-8-11-28-27-23(22)16-24(29-27)20-9-14-30(15-10-20)18-26(34)31-12-4-3-5-13-31/h6-8,11,16-17,19-20H,3-5,9-10,12-15,18H2,1-2H3,(H,28,29) GLYHKPNATCXTDU-UHFFFAOYSA-N 50588262 CHEMBL5197170 Cyclin-dependent kinase 7 Homo sapiens 16000 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588262&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 163196243 482599114 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51457431 CC(C)n1cc(ccc1=O)-c1ccnc2[nH]c(cc12)C1CCN(CC(=O)N2CCCC2)CC1 InChI=1S/C26H33N5O2/c1-18(2)31-16-20(5-6-24(31)32)21-7-10-27-26-22(21)15-23(28-26)19-8-13-29(14-9-19)17-25(33)30-11-3-4-12-30/h5-7,10,15-16,18-19H,3-4,8-9,11-14,17H2,1-2H3,(H,27,28) GNWQPICFCPORII-UHFFFAOYSA-N 50588264 CHEMBL5207871 Cyclin-dependent kinase 7 Homo sapiens 18000 ChEMBL 10.7270/Q2F193PM 34647738 Barlaam, B; De Savi, C; Dishington, A; Drew, L; Ferguson, AD; Ferguson, D; Gu, C; Hande, S; Hassall, L; Hawkins, J; Hird, AW; Holmes, J; Lamb, ML; Lister, AS; McGuire, TM; Moore, JE; O'Connell, N; Patel, A; Pike, KG; Sarkar, U; Shao, W; Stead, D; Varnes, JG; Vasbinder, MM; Wang, L; Wu, L; Xue, L; Yang, B; Yao, T AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588264&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168294347 482599116 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275295 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US11643416, Compound 1 Cyclin-dependent kinase 7 Homo sapiens 560 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275300 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 2 Cyclin-dependent kinase 7 Homo sapiens 200 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275305 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 3 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275309 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 4 Cyclin-dependent kinase 7 Homo sapiens 230 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275314 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 12 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275319 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m0/s1 FKAJEPVSQITQLJ-INIZCTEOSA-N 601938 (R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 18 Cyclin-dependent kinase 7 Homo sapiens 840 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275324 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26)/t13-/m0/s1 ZJKDYTFNXUBLEQ-ZDUSSCGKSA-N 601939 (S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 19 Cyclin-dependent kinase 7 Homo sapiens 800 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275328 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 5 Cyclin-dependent kinase 7 Homo sapiens 875 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275332 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m1/s1 FKAJEPVSQITQLJ-MRXNPFEDSA-N 601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23 Cyclin-dependent kinase 7 Homo sapiens 682 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275336 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 42 Cyclin-dependent kinase 7 Homo sapiens 83.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275340 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 43 Cyclin-dependent kinase 7 Homo sapiens 250 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275344 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 45 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275348 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 46 Cyclin-dependent kinase 7 Homo sapiens 723 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275352 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 49 Cyclin-dependent kinase 7 Homo sapiens 242 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275356 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 50 Cyclin-dependent kinase 7 Homo sapiens 118 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275360 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 51 Cyclin-dependent kinase 7 Homo sapiens 66.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275364 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 52 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275368 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 53 Cyclin-dependent kinase 7 Homo sapiens 615 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275372 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 54 Cyclin-dependent kinase 7 Homo sapiens 144 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275376 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US11643416, Compound 55 Cyclin-dependent kinase 7 Homo sapiens 27.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275380 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 59 Cyclin-dependent kinase 7 Homo sapiens 16.0 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275384 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 61 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275388 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 62 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275392 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 63 Cyclin-dependent kinase 7 Homo sapiens 579 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275396 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 64 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1275402 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 74 Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2VX0MGD US11643416 Strum, JC G1 Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50230526 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 10.0 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50230527 C[C@H](CO)Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Br InChI=1S/C13H16BrN5O3S/c1-8(7-20)17-12-11(14)6-16-13(19-12)18-9-2-4-10(5-3-9)23(15,21)22/h2-6,8,20H,7H2,1H3,(H2,15,21,22)(H2,16,17,18,19)/t8-/m1/s1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 50553480 CHEMBL4741442 Cyclin-dependent kinase 7 Homo sapiens 85 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553480&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3I6 4BGH 58890996 461692248 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50230529 COc1ccc2ccc(cc2c1)S(=O)(=O)NC(CCCNC(N)=N)C(=O)N1CCCCCC1C(O)=O InChI=1S/C24H33N5O6S/c1-35-18-10-8-16-9-11-19(15-17(16)14-18)36(33,34)28-20(6-5-12-27-24(25)26)22(30)29-13-4-2-3-7-21(29)23(31)32/h8-11,14-15,20-21,28H,2-7,12-13H2,1H3,(H,31,32)(H4,25,26,27) VBGNIIGPQKKQBE-UHFFFAOYSA-N 50404387 CHEMBL5287128 Cyclin-dependent kinase 7 Homo sapiens 25 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50404387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50404387&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44459651 163353411 CHEMBL24657 ZINC28755486 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50272944 CC[C@@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m0/s1 BTIHMVBBUGXLCJ-HNNXBMFYSA-N 50056163 (S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol::(S)-2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol::CHEMBL133342 Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056163&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6603989 103952519 CHEMBL133342 ZINC00602192 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50360375 CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1 DLPIYBKBHMZCJI-WBVHZDCISA-N 106950 US8592581, 1 Cyclin-dependent kinase 7 Homo sapiens 193 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106950&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24983461 174009261 ZINC96177788 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50360376 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-dependent kinase 7 Homo sapiens 520 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50360377 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50410916 O=C1NCCc2[nH]c(cc12)-c1ccncc1 InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) DKXHSOUZPMHNIZ-UHFFFAOYSA-N 27344 2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::JMC502647 Compound 8::Pyrrolopyridinone, 1 Cyclin-dependent kinase 7 Homo sapiens 10.0 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27344&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 0SY 4F9B 11715767 57299053 ZINC16052718 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50565931 Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C18H25ClN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24)/t12-,13- RVZJFCNYSSUDCU-JOCQHMNTSA-N 50553499 CHEMBL4754493 Cyclin-dependent kinase 7 Homo sapiens 1.3 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553499&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126558497 461692267 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50596026 COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6-4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22) GGQCIOOSELPMBB-UHFFFAOYSA-N 50013510 CHEMBL3263773 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013510&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25104564 242058283 CHEMBL3263773 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50596034 COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 InChI=1S/C27H37ClN6O2/c1-19(16-35-2)32-20-6-8-21(9-7-20)33-26-14-22(23(28)15-30-26)24-4-3-5-25(34-24)31-18-27(17-29)10-12-36-13-11-27/h3-5,14-15,19-21,32H,6-13,16,18H2,1-2H3,(H,30,33)(H,31,34)/t19-,20-,21-/m1/s1 XWQVQSXLXAXOPJ-NJDAHSKKSA-N 126500 US11591322, Compound NVP-2::US8778951, 310 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=126500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=126500&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 66937006 225152858 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50598331 CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 InChI=1S/C16H25N5/c1-3-11(4-2)14-10-16(19-13-6-5-12(17)9-13)21-15(20-14)7-8-18-21/h7-8,10-13,19H,3-6,9,17H2,1-2H3/t12-,13-/m0/s1 VYKCLMALANGCDF-STQMWFEESA-N 50593922 CHEMBL5199065 Cyclin-dependent kinase 7 Homo sapiens >1200 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50593922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50593922&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search VQE 8K5R 146502834 482604774 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50598332 COCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1ccc2cc3OCCOc3cc2c1 InChI=1S/C23H31N5O8S/c1-34-8-7-28(14-21(29)30)22(31)18(3-2-6-26-23(24)25)27-37(32,33)17-5-4-15-12-19-20(13-16(15)11-17)36-10-9-35-19/h4-5,11-13,18,27H,2-3,6-10,14H2,1H3,(H,29,30)(H4,24,25,26) CPCGYQXBIVPIAV-UHFFFAOYSA-N 50404389 CHEMBL5285499 Cyclin-dependent kinase 7 Homo sapiens 8800 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50404389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50404389&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44459892 163353413 CHEMBL282192 ZINC28757251 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50598838 COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 167699 US9073922, 186::US9796708, Example 186 Cyclin-dependent kinase 7 Homo sapiens >20000 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167699&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90414175 312321544 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50598839 COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O 354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid Cyclin-dependent kinase 7 Homo sapiens 14400 ChEMBL 10.7270/Q24B35H7 35814933 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=354126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=354126&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90419627 386047858 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51499003 COc1cc(F)ccc1-c1cnc2sc(nn12)N1CCC(C)(N)CC1 InChI=1S/C17H20FN5OS/c1-17(19)5-7-22(8-6-17)16-21-23-13(10-20-15(23)25-16)12-4-3-11(18)9-14(12)24-2/h3-4,9-10H,5-8,19H2,1-2H3 KUQLTAUECPDOLQ-UHFFFAOYSA-N 50603977 CHEMBL5189523 Cyclin-dependent kinase 7 Homo sapiens 12000 ChEMBL 10.7270/Q2H70KXT 35229610 Taft, BR; Yokokawa, F; Kirrane, T; Mata, AC; Huang, R; Blaquiere, N; Waldron, G; Zou, B; Simon, O; Vankadara, S; Chan, WL; Ding, M; Sim, S; Straimer, J; Guiguemde, A; Lakshminarayana, SB; Jain, JP; Bodenreider, C; Thompson, C; Lanshoeft, C; Shu, W; Fang, E; Qumber, J; Chan, K; Pei, L; Chen, YL; Schulz, H; Lim, J; Abas, SN; Ang, X; Liu, Y; Angulo-Barturen, I; Jiménez-Díaz, MB; Gamo, FJ; Crespo-Fernandez, B; Rosenthal, PJ; Cooper, RA; Tumwebaze, P; Aguiar, ACC; Campo, B; Campbell, S; Wagner, J; Diagana, TT; Sarko, C Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50603977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50603977&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168282822 482614828 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51499004 CC(C)(N)CNc1nn2c(cnc2s1)-c1ccc(F)cc1F InChI=1S/C14H15F2N5S/c1-14(2,17)7-19-12-20-21-11(6-18-13(21)22-12)9-4-3-8(15)5-10(9)16/h3-6H,7,17H2,1-2H3,(H,19,20) ZJKIGHOTHYACFW-UHFFFAOYSA-N 50603992 CHEMBL5179988 Cyclin-dependent kinase 7 Homo sapiens 200 ChEMBL 10.7270/Q2H70KXT 35229610 Taft, BR; Yokokawa, F; Kirrane, T; Mata, AC; Huang, R; Blaquiere, N; Waldron, G; Zou, B; Simon, O; Vankadara, S; Chan, WL; Ding, M; Sim, S; Straimer, J; Guiguemde, A; Lakshminarayana, SB; Jain, JP; Bodenreider, C; Thompson, C; Lanshoeft, C; Shu, W; Fang, E; Qumber, J; Chan, K; Pei, L; Chen, YL; Schulz, H; Lim, J; Abas, SN; Ang, X; Liu, Y; Angulo-Barturen, I; Jiménez-Díaz, MB; Gamo, FJ; Crespo-Fernandez, B; Rosenthal, PJ; Cooper, RA; Tumwebaze, P; Aguiar, ACC; Campo, B; Campbell, S; Wagner, J; Diagana, TT; Sarko, C Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50603992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50603992&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168275535 482614843 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514437 NC[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C28H26N6O/c29-15-23(19-7-3-1-4-8-19)17-31-24-13-22(16-30-18-24)21-11-12-26-25(14-21)27(34-33-26)32-28(35)20-9-5-2-6-10-20/h1-14,16,18,23,31H,15,17,29H2,(H2,32,33,34,35)/t23-/m0/s1 HOIDDIAWOSDERZ-QHCPKHFHSA-N 50609496 CHEMBL5284748 Cyclin-dependent kinase 7 Homo sapiens 395 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609496&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171346876 494499244 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514438 N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C28H24N6O2/c29-24(13-18-7-3-1-4-8-18)28(36)31-22-14-21(16-30-17-22)20-11-12-25-23(15-20)26(34-33-25)32-27(35)19-9-5-2-6-10-19/h1-12,14-17,24H,13,29H2,(H,31,36)(H2,32,33,34,35)/t24-/m0/s1 FOBQDUDIHLWHMU-DEOSSOPVSA-N 50609497 CHEMBL5277013 Cyclin-dependent kinase 7 Homo sapiens 1341 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609497&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171357718 494499245 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514439 N[C@H](Cc1ccccc1)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C28H24N6O2/c29-24(13-18-7-3-1-4-8-18)28(36)31-22-14-21(16-30-17-22)20-11-12-25-23(15-20)26(34-33-25)32-27(35)19-9-5-2-6-10-19/h1-12,14-17,24H,13,29H2,(H,31,36)(H2,32,33,34,35)/t24-/m1/s1 FOBQDUDIHLWHMU-XMMPIXPASA-N 50609498 CHEMBL5270227 Cyclin-dependent kinase 7 Homo sapiens 2073 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609498&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171343786 494499246 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514440 N[C@H](C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C27H22N6O2/c28-24(17-7-3-1-4-8-17)27(35)30-21-13-20(15-29-16-21)19-11-12-23-22(14-19)25(33-32-23)31-26(34)18-9-5-2-6-10-18/h1-16,24H,28H2,(H,30,35)(H2,31,32,33,34)/t24-/m0/s1 QSWVPKLCGKLABE-DEOSSOPVSA-N 50609499 CHEMBL5287678 Cyclin-dependent kinase 7 Homo sapiens 3142 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609499&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171348093 494499247 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514441 O[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H26N6O3/c1-2-28(38)33-23-11-8-20(9-12-23)30(39)34-29-25-15-21(10-13-26(25)35-36-29)22-14-24(17-31-16-22)32-18-27(37)19-6-4-3-5-7-19/h2-17,27,32,37H,1,18H2,(H,33,38)(H2,34,35,36,39)/t27-/m0/s1 VSTRBHWJZOVRDC-MHZLTWQESA-N 50609500 CHEMBL5286683 Cyclin-dependent kinase 7 Homo sapiens 6.0 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609500&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171348355 494499248 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514442 O[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H26N6O3/c1-2-28(38)33-23-11-8-20(9-12-23)30(39)34-29-25-15-21(10-13-26(25)35-36-29)22-14-24(17-31-16-22)32-18-27(37)19-6-4-3-5-7-19/h2-17,27,32,37H,1,18H2,(H,33,38)(H2,34,35,36,39)/t27-/m1/s1 VSTRBHWJZOVRDC-HHHXNRCGSA-N 50609501 CHEMBL5288241 Cyclin-dependent kinase 7 Homo sapiens 4.0 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609501&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 166176962 494499249 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514443 OC[C@@H](Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H26N6O3/c1-2-28(38)33-23-11-8-20(9-12-23)30(39)34-29-25-15-21(10-13-26(25)35-36-29)22-14-24(17-31-16-22)32-27(18-37)19-6-4-3-5-7-19/h2-17,27,32,37H,1,18H2,(H,33,38)(H2,34,35,36,39)/t27-/m1/s1 FADBFXGGKHHVNR-HHHXNRCGSA-N 50609502 CHEMBL5273413 Cyclin-dependent kinase 7 Homo sapiens 19 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609502&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171345847 494499250 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514444 OC[C@H](Cc1ccccc1)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1 InChI=1S/C31H28N6O3/c1-2-29(39)34-24-11-8-21(9-12-24)31(40)35-30-27-16-22(10-13-28(27)36-37-30)23-15-25(18-32-17-23)33-26(19-38)14-20-6-4-3-5-7-20/h2-13,15-18,26,33,38H,1,14,19H2,(H,34,39)(H2,35,36,37,40)/t26-/m0/s1 AJNPBOWCTJZTHG-SANMLTNESA-N 50609503 CHEMBL5269885 Cyclin-dependent kinase 7 Homo sapiens 5.0 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609503&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171343569 494499251 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514445 N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1 InChI=1S/C31H27N7O3/c1-2-28(39)34-23-11-8-20(9-12-23)30(40)36-29-25-16-21(10-13-27(25)37-38-29)22-15-24(18-33-17-22)35-31(41)26(32)14-19-6-4-3-5-7-19/h2-13,15-18,26H,1,14,32H2,(H,34,39)(H,35,41)(H2,36,37,38,40)/t26-/m0/s1 RKKBVXKJICHLRV-SANMLTNESA-N 50609504 CHEMBL5274920 Cyclin-dependent kinase 7 Homo sapiens 7.0 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609504&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171353218 494499252 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514446 N[C@H](C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H25N7O3/c1-2-26(38)33-22-11-8-19(9-12-22)29(39)35-28-24-15-20(10-13-25(24)36-37-28)21-14-23(17-32-16-21)34-30(40)27(31)18-6-4-3-5-7-18/h2-17,27H,1,31H2,(H,33,38)(H,34,40)(H2,35,36,37,39)/t27-/m0/s1 PBVJBBMJZRSVHI-MHZLTWQESA-N 50609505 CHEMBL5277284 Cyclin-dependent kinase 7 Homo sapiens 64 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609505&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171352962 494499253 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514447 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-dependent kinase 7 Homo sapiens 22 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514470 O[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 InChI=1S/C30H26N6O3/c1-2-28(38)33-23-11-8-20(9-12-23)30(39)34-29-25-15-21(10-13-26(25)35-36-29)22-14-24(17-31-16-22)32-18-27(37)19-6-4-3-5-7-19/h2-17,27,32,37H,1,18H2,(H,33,38)(H2,34,35,36,39)/t27-/m1/s1 VSTRBHWJZOVRDC-HHHXNRCGSA-N 50609501 CHEMBL5288241 Cyclin-dependent kinase 7 Homo sapiens 4.0 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609501&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 166176962 494499249 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514418 O=C(Nc1n[nH]c2ccc(cc12)-c1cccnc1)c1ccccc1 InChI=1S/C19H14N4O/c24-19(13-5-2-1-3-6-13)21-18-16-11-14(8-9-17(16)22-23-18)15-7-4-10-20-12-15/h1-12H,(H2,21,22,23,24) IWELHDSHFPVSNI-UHFFFAOYSA-N 50609477 CHEMBL5271103 Cyclin-dependent kinase 7 Homo sapiens 7550 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609477&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171344437 494499225 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514419 Oc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C19H14N4O2/c24-15-8-14(10-20-11-15)13-6-7-17-16(9-13)18(23-22-17)21-19(25)12-4-2-1-3-5-12/h1-11,24H,(H2,21,22,23,25) INAQUFUHHQJFNF-UHFFFAOYSA-N 50609478 CHEMBL5291397 Cyclin-dependent kinase 7 Homo sapiens 7237 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609478&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171351779 494499226 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514420 Cc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C20H16N4O/c1-13-9-16(12-21-11-13)15-7-8-18-17(10-15)19(24-23-18)22-20(25)14-5-3-2-4-6-14/h2-12H,1H3,(H2,22,23,24,25) VHFOYAVJKHGBEL-UHFFFAOYSA-N 50609479 CHEMBL5290154 Cyclin-dependent kinase 7 Homo sapiens 2608 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609479&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171358233 494499227 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514421 COc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C20H16N4O2/c1-26-16-9-15(11-21-12-16)14-7-8-18-17(10-14)19(24-23-18)22-20(25)13-5-3-2-4-6-13/h2-12H,1H3,(H2,22,23,24,25) OIQSIOZCBAIBDR-UHFFFAOYSA-N 50609480 CHEMBL5286971 Cyclin-dependent kinase 7 Homo sapiens 5530 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609480&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171346475 494499228 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514422 CNC(=O)c1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C21H17N5O2/c1-22-20(27)16-9-15(11-23-12-16)14-7-8-18-17(10-14)19(26-25-18)24-21(28)13-5-3-2-4-6-13/h2-12H,1H3,(H,22,27)(H2,24,25,26,28) WOWZSBFKHYIANX-UHFFFAOYSA-N 50609481 CHEMBL5278281 Cyclin-dependent kinase 7 Homo sapiens 3782 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609481&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171356939 494499229 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514423 NCCOc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C21H19N5O2/c22-8-9-28-17-10-16(12-23-13-17)15-6-7-19-18(11-15)20(26-25-19)24-21(27)14-4-2-1-3-5-14/h1-7,10-13H,8-9,22H2,(H2,24,25,26,27) JSTNGLYSRYVJRB-UHFFFAOYSA-N 50609482 CHEMBL5274271 Cyclin-dependent kinase 7 Homo sapiens 1996 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609482&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171356155 494499230 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514424 OCCNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C21H19N5O2/c27-9-8-23-17-10-16(12-22-13-17)15-6-7-19-18(11-15)20(26-25-19)24-21(28)14-4-2-1-3-5-14/h1-7,10-13,23,27H,8-9H2,(H2,24,25,26,28) XPCWXGVVHHQNTJ-UHFFFAOYSA-N 50609483 CHEMBL5270192 Cyclin-dependent kinase 7 Homo sapiens 1712 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609483&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171344063 494499231 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514425 NCCNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C21H20N6O/c22-8-9-24-17-10-16(12-23-13-17)15-6-7-19-18(11-15)20(27-26-19)25-21(28)14-4-2-1-3-5-14/h1-7,10-13,24H,8-9,22H2,(H2,25,26,27,28) UQZDTKWBNWWIDE-UHFFFAOYSA-N 50609484 CHEMBL5287087 Cyclin-dependent kinase 7 Homo sapiens 1556 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609484&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171344781 494499232 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514426 NCC(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1 InChI=1S/C21H18N6O2/c22-10-19(28)24-16-8-15(11-23-12-16)14-6-7-18-17(9-14)20(27-26-18)25-21(29)13-4-2-1-3-5-13/h1-9,11-12H,10,22H2,(H,24,28)(H2,25,26,27,29) NTSSUJCNVYPSDG-UHFFFAOYSA-N 50609485 CHEMBL5288651 Cyclin-dependent kinase 7 Homo sapiens 2490 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609485&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171349662 494499233 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514427 N[C@H](COc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)Cc1ccccc1 InChI=1S/C28H25N5O2/c29-23(13-19-7-3-1-4-8-19)18-35-24-14-22(16-30-17-24)21-11-12-26-25(15-21)27(33-32-26)31-28(34)20-9-5-2-6-10-20/h1-12,14-17,23H,13,18,29H2,(H2,31,32,33,34)/t23-/m0/s1 FJEXBYVIDPXIBM-QHCPKHFHSA-N 50609486 CHEMBL5290362 Cyclin-dependent kinase 7 Homo sapiens 335 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609486&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171358431 494499234 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514428 N[C@@H](COc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)Cc1ccccc1 InChI=1S/C28H25N5O2/c29-23(13-19-7-3-1-4-8-19)18-35-24-14-22(16-30-17-24)21-11-12-26-25(15-21)27(33-32-26)31-28(34)20-9-5-2-6-10-20/h1-12,14-17,23H,13,18,29H2,(H2,31,32,33,34)/t23-/m1/s1 FJEXBYVIDPXIBM-HSZRJFAPSA-N 50609487 CHEMBL5285145 Cyclin-dependent kinase 7 Homo sapiens 2394 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609487&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171347757 494499235 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514429 N[C@H](COc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C27H23N5O2/c28-24(18-7-3-1-4-8-18)17-34-22-13-21(15-29-16-22)20-11-12-25-23(14-20)26(32-31-25)30-27(33)19-9-5-2-6-10-19/h1-16,24H,17,28H2,(H2,30,31,32,33)/t24-/m1/s1 IQTQYWDGDRKZSH-XMMPIXPASA-N 50609488 CHEMBL5287079 Cyclin-dependent kinase 7 Homo sapiens 692 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609488&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171349019 494499236 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514430 N[C@@H](COc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C27H23N5O2/c28-24(18-7-3-1-4-8-18)17-34-22-13-21(15-29-16-22)20-11-12-25-23(14-20)26(32-31-25)30-27(33)19-9-5-2-6-10-19/h1-16,24H,17,28H2,(H2,30,31,32,33)/t24-/m0/s1 IQTQYWDGDRKZSH-DEOSSOPVSA-N 50609489 CHEMBL5290719 Cyclin-dependent kinase 7 Homo sapiens 4918 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609489&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171358708 494499237 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514431 O[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C27H23N5O2/c33-25(18-7-3-1-4-8-18)17-29-22-13-21(15-28-16-22)20-11-12-24-23(14-20)26(32-31-24)30-27(34)19-9-5-2-6-10-19/h1-16,25,29,33H,17H2,(H2,30,31,32,34)/t25-/m0/s1 OSTSMXLBOZDZHJ-VWLOTQADSA-N 50609490 CHEMBL5281785 Cyclin-dependent kinase 7 Homo sapiens 311 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609490&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171356403 494499238 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514432 O[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C27H23N5O2/c33-25(18-7-3-1-4-8-18)17-29-22-13-21(15-28-16-22)20-11-12-24-23(14-20)26(32-31-24)30-27(34)19-9-5-2-6-10-19/h1-16,25,29,33H,17H2,(H2,30,31,32,34)/t25-/m1/s1 OSTSMXLBOZDZHJ-RUZDIDTESA-N 50609491 CHEMBL5276424 Cyclin-dependent kinase 7 Homo sapiens 440 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609491&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171356244 494499239 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514433 OC[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C28H25N5O2/c34-18-23(19-7-3-1-4-8-19)16-30-24-13-22(15-29-17-24)21-11-12-26-25(14-21)27(33-32-26)31-28(35)20-9-5-2-6-10-20/h1-15,17,23,30,34H,16,18H2,(H2,31,32,33,35)/t23-/m0/s1 MDZCVSJGYQSCCO-QHCPKHFHSA-N 50609492 CHEMBL5268968 Cyclin-dependent kinase 7 Homo sapiens 710 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609492&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171344364 494499240 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514434 OC[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)c1ccccc1 InChI=1S/C28H25N5O2/c34-18-23(19-7-3-1-4-8-19)16-30-24-13-22(15-29-17-24)21-11-12-26-25(14-21)27(33-32-26)31-28(35)20-9-5-2-6-10-20/h1-15,17,23,30,34H,16,18H2,(H2,31,32,33,35)/t23-/m1/s1 MDZCVSJGYQSCCO-HSZRJFAPSA-N 50609493 CHEMBL5280467 Cyclin-dependent kinase 7 Homo sapiens 1726 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609493&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171353084 494499241 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514435 OC[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)Cc1ccccc1 InChI=1S/C29H27N5O2/c35-19-21(13-20-7-3-1-4-8-20)16-31-25-14-24(17-30-18-25)23-11-12-27-26(15-23)28(34-33-27)32-29(36)22-9-5-2-6-10-22/h1-12,14-15,17-18,21,31,35H,13,16,19H2,(H2,32,33,34,36)/t21-/m0/s1 MLRFEYKWKAWGAL-NRFANRHFSA-N 50609494 CHEMBL5283549 Cyclin-dependent kinase 7 Homo sapiens 670 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609494&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171347127 494499242 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51514436 OC[C@@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccccc3)c2c1)Cc1ccccc1 InChI=1S/C29H27N5O2/c35-19-21(13-20-7-3-1-4-8-20)16-31-25-14-24(17-30-18-25)23-11-12-27-26(15-23)28(34-33-27)32-29(36)22-9-5-2-6-10-22/h1-12,14-15,17-18,21,31,35H,13,16,19H2,(H2,32,33,34,36)/t21-/m1/s1 MLRFEYKWKAWGAL-OAQYLSRUSA-N 50609495 CHEMBL5283085 Cyclin-dependent kinase 7 Homo sapiens 2638 ChEMBL 10.7270/Q29K4GGV 36384292 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609495&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171352164 494499243 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362159 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib::US11857552, Compound REF-001 Cyclin-dependent kinase 7 Homo sapiens 34.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,8P6V,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362162 CCc1cnn2c(NCc3ccccc3F)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C21H27FN6O/c1-2-14-12-26-28-20(25-10-15-5-3-4-6-17(15)22)9-19(27-21(14)28)24-11-16-7-8-23-13-18(16)29/h3-6,9,12,16,18,23,25,29H,2,7-8,10-11,13H2,1H3,(H,24,27)/t16-,18+/m1/s1 YSKUCLKVLULVQM-AEFFLSMTSA-N 642787 US11857552, Compound APPAMP-001 Cyclin-dependent kinase 7 Homo sapiens 13.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 142547559 488875630 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362165 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccccc2)n2ncc(C3CC3)c2n1 InChI=1S/C22H28N6O/c29-19-14-23-9-8-17(19)12-24-20-10-21(25-11-15-4-2-1-3-5-15)28-22(27-20)18(13-26-28)16-6-7-16/h1-5,10,13,16-17,19,23,25,29H,6-9,11-12,14H2,(H,24,27)/t17-,19+/m1/s1 ATGAGBNTLIIJJW-MJGOQNOKSA-N 642788 US11857552, Compound APPAMP-002 Cyclin-dependent kinase 7 Homo sapiens 33.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642788&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138498691 488875631 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362168 CCc1cnn2c(NCc3cccc(c3)C#N)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H27N7O/c1-2-17-13-27-29-21(26-11-16-5-3-4-15(8-16)10-23)9-20(28-22(17)29)25-12-18-6-7-24-14-19(18)30/h3-5,8-9,13,18-19,24,26,30H,2,6-7,11-12,14H2,1H3,(H,25,28)/t18-,19+/m1/s1 MRWKUIOLQRITLV-MOPGFXCFSA-N 642789 US11857552, Compound APPAMP-003 Cyclin-dependent kinase 7 Homo sapiens 8.90 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642789&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138490452 488875632 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362171 CCc1cnn2c(NCc3cccc(c3)C#N)c(Cl)c(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H26ClN7O/c1-2-16-12-28-30-21(16)29-20(26-11-17-6-7-25-13-18(17)31)19(23)22(30)27-10-15-5-3-4-14(8-15)9-24/h3-5,8,12,17-18,25,27,31H,2,6-7,10-11,13H2,1H3,(H,26,29)/t17-,18+/m1/s1 CPZWNPKQAYBTEE-MSOLQXFVSA-N 642790 US11857552, Compound APPAMP-004 Cyclin-dependent kinase 7 Homo sapiens 4.20 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642790&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138496369 488875633 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362173 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib::US11857552, Compound REF-001 Cyclin-dependent kinase 7 Homo sapiens 34.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,8P6V,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362174 CCc1cnn2c(NCc3cccc(c3)C#N)c(Cl)c(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H26ClN7O/c1-2-16-12-28-30-21(16)29-20(26-11-17-6-7-25-13-18(17)31)19(23)22(30)27-10-15-5-3-4-14(8-15)9-24/h3-5,8,12,17-18,25,27,31H,2,6-7,10-11,13H2,1H3,(H,26,29)/t17-,18+/m1/s1 CPZWNPKQAYBTEE-MSOLQXFVSA-N 642790 US11857552, Compound APPAMP-004 Cyclin-dependent kinase 7 Homo sapiens 4.20 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642790&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138496369 488875633 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362175 CCc1cnn2c(NCc3cccc(c3)C#N)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H27N7O/c1-2-17-13-27-29-21(26-11-16-5-3-4-15(8-16)10-23)9-20(28-22(17)29)25-12-18-6-7-24-14-19(18)30/h3-5,8-9,13,18-19,24,26,30H,2,6-7,11-12,14H2,1H3,(H,25,28)/t18-,19+/m1/s1 MRWKUIOLQRITLV-MOPGFXCFSA-N 642789 US11857552, Compound APPAMP-003 Cyclin-dependent kinase 7 Homo sapiens 8.90 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642789&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138490452 488875632 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362176 CCc1cnn2c(NCc3ccccc3F)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C21H27FN6O/c1-2-14-12-26-28-20(25-10-15-5-3-4-6-17(15)22)9-19(27-21(14)28)24-11-16-7-8-23-13-18(16)29/h3-6,9,12,16,18,23,25,29H,2,7-8,10-11,13H2,1H3,(H,24,27)/t16-,18+/m1/s1 YSKUCLKVLULVQM-AEFFLSMTSA-N 642787 US11857552, Compound APPAMP-001 Cyclin-dependent kinase 7 Homo sapiens 13.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 142547559 488875630 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362177 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccccc2)n2ncc(C3CC3)c2n1 InChI=1S/C22H28N6O/c29-19-14-23-9-8-17(19)12-24-20-10-21(25-11-15-4-2-1-3-5-15)28-22(27-20)18(13-26-28)16-6-7-16/h1-5,10,13,16-17,19,23,25,29H,6-9,11-12,14H2,(H,24,27)/t17-,19+/m1/s1 ATGAGBNTLIIJJW-MJGOQNOKSA-N 642788 US11857552, Compound APPAMP-002 Cyclin-dependent kinase 7 Homo sapiens 33.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642788&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138498691 488875631 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362179 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib::US11857552, Compound REF-001 Cyclin-dependent kinase 7 Homo sapiens 34.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,8P6V,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362181 CCc1cnn2c(NCc3cccc(c3)C#N)c(Cl)c(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H26ClN7O/c1-2-16-12-28-30-21(16)29-20(26-11-17-6-7-25-13-18(17)31)19(23)22(30)27-10-15-5-3-4-14(8-15)9-24/h3-5,8,12,17-18,25,27,31H,2,6-7,10-11,13H2,1H3,(H,26,29)/t17-,18+/m1/s1 CPZWNPKQAYBTEE-MSOLQXFVSA-N 642790 US11857552, Compound APPAMP-004 Cyclin-dependent kinase 7 Homo sapiens 4.20 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642790&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138496369 488875633 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362183 CCc1cnn2c(NCc3ccccc3F)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C21H27FN6O/c1-2-14-12-26-28-20(25-10-15-5-3-4-6-17(15)22)9-19(27-21(14)28)24-11-16-7-8-23-13-18(16)29/h3-6,9,12,16,18,23,25,29H,2,7-8,10-11,13H2,1H3,(H,24,27)/t16-,18+/m1/s1 YSKUCLKVLULVQM-AEFFLSMTSA-N 642787 US11857552, Compound APPAMP-001 Cyclin-dependent kinase 7 Homo sapiens 13.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 142547559 488875630 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362185 O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccccc2)n2ncc(C3CC3)c2n1 InChI=1S/C22H28N6O/c29-19-14-23-9-8-17(19)12-24-20-10-21(25-11-15-4-2-1-3-5-15)28-22(27-20)18(13-26-28)16-6-7-16/h1-5,10,13,16-17,19,23,25,29H,6-9,11-12,14H2,(H,24,27)/t17-,19+/m1/s1 ATGAGBNTLIIJJW-MJGOQNOKSA-N 642788 US11857552, Compound APPAMP-002 Cyclin-dependent kinase 7 Homo sapiens 33.0 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642788&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138498691 488875631 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1362187 CCc1cnn2c(NCc3cccc(c3)C#N)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H27N7O/c1-2-17-13-27-29-21(26-11-16-5-3-4-15(8-16)10-23)9-20(28-22(17)29)25-12-18-6-7-24-14-19(18)30/h3-5,8-9,13,18-19,24,26,30H,2,6-7,11-12,14H2,1H3,(H,25,28)/t18-,19+/m1/s1 MRWKUIOLQRITLV-MOPGFXCFSA-N 642789 US11857552, Compound APPAMP-003 Cyclin-dependent kinase 7 Homo sapiens 8.90 US Patent 10.7270/Q2S186PK US11857552 Bahl, A; Ainscow, E; Bondke, A; Barrett, AG; Sunose, M; Shiers, JJ; Chohan, K Carrick Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642789&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 138490452 488875632 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51509182 O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(CCCCCC1)C1=CC=CC1 InChI=1S/C29H40NO3/c31-28(29(25-11-6-7-12-25)17-8-1-2-9-18-29)33-27-23-30(20-15-24(27)16-21-30)19-10-22-32-26-13-4-3-5-14-26/h3-7,11,13-14,24,27H,1-2,8-10,12,15-23H2/q+1/t24?,27-,30?/m0/s1 AKFPOKNYHMXDIT-ROTRRZJSSA-N 50443280 CHEMBL5273925 Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443280&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72545526 194941176 CHEMBL3088086 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51509183 CC(C)CC(=O)Nc1[nH]nc2c1CN(C(=O)C1CCN(C)CC1)C2(C)C InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25) HUXYBQXJVXOMKX-UHFFFAOYSA-N 50378657 CHEMBL1230607 Cyclin-dependent kinase 7 Homo sapiens 10.0 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378657&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46191454 160857740 CHEMBL1230607 ZINC52509437 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51509184 CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12 InChI=1S/C22H30N6O/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27)/t17-,19+/m1/s1 YCVGLKWJKIKVBI-MJGOQNOKSA-N 50526797 Ct-7001::Ct7001::ICEC-0942::ICEC0942::Samuraciclib::US11857552, Compound REF-001 Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.7270/Q2PK0MC2 32707525 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search I74 5JQ5,8P6V,7B5Q,7B5O 91844733 440735379 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396961 C=CC(=O)NCCN1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C25H32N6O3/c1-2-23(32)26-7-10-30-8-5-18(6-9-30)19-3-4-22-21(15-19)29-24-20(16-34-22)25(28-17-27-24)31-11-13-33-14-12-31/h2-4,15,17-18H,1,5-14,16H2,(H,26,32)(H,27,28,29) GYIAGSMFOIMOEU-UHFFFAOYSA-N 663240 US20240109912, Compound 3 Cyclin-dependent kinase 7 Homo sapiens 1029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663240&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396962 C=CC(=O)N1CC[C@@H](C1)N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C27H34N6O3/c1-2-25(34)33-10-7-21(16-33)31-8-5-19(6-9-31)20-3-4-24-23(15-20)30-26-22(17-36-24)27(29-18-28-26)32-11-13-35-14-12-32/h2-4,15,18-19,21H,1,5-14,16-17H2,(H,28,29,30)/t21-/m0/s1 SBNCTJPGVDJQTI-NRFANRHFSA-N 663241 US20240109912, Compound 5 Cyclin-dependent kinase 7 Homo sapiens 595 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663241&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396963 C=CC(=O)N1CC(C1)N1CCN(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C25H31N7O3/c1-2-23(33)32-14-19(15-32)30-7-5-29(6-8-30)18-3-4-22-21(13-18)28-24-20(16-35-22)25(27-17-26-24)31-9-11-34-12-10-31/h2-4,13,17,19H,1,5-12,14-16H2,(H,26,27,28) QJPLSAPEPXDDPY-UHFFFAOYSA-N 663619 US20240109912, Compound 6 Cyclin-dependent kinase 7 Homo sapiens 2731 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663619&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396964 C=CC(=O)N1CC(C1)C1CCN(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C26H32N6O3/c1-2-24(33)32-14-19(15-32)18-5-7-30(8-6-18)20-3-4-23-22(13-20)29-25-21(16-35-23)26(28-17-27-25)31-9-11-34-12-10-31/h2-4,13,17-19H,1,5-12,14-16H2,(H,27,28,29) DWIXZQZEGSFGFY-UHFFFAOYSA-N 663620 US20240109912, Compound 7 Cyclin-dependent kinase 7 Homo sapiens 1792 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663620&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396965 Cn1cc(ccc1=O)-c1ncnc2Nc3cc(ccc3OCc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H30N6O3/c1-3-25(35)34-14-21(15-34)33-10-8-18(9-11-33)19-4-6-24-23(12-19)31-28-22(16-37-24)27(29-17-30-28)20-5-7-26(36)32(2)13-20/h3-7,12-13,17-18,21H,1,8-11,14-16H2,2H3,(H,29,30,31) XPGHVAZHWCGRQJ-UHFFFAOYSA-N 663623 US20240109912, Compound 8 Cyclin-dependent kinase 7 Homo sapiens 251 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663623&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396966 C=CC(=O)N1CC(C1)N1CC[C@@H](C1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C25H30N6O3/c1-2-23(32)31-13-19(14-31)30-6-5-18(12-30)17-3-4-22-21(11-17)28-24-20(15-34-22)25(27-16-26-24)29-7-9-33-10-8-29/h2-4,11,16,18-19H,1,5-10,12-15H2,(H,26,27,28)/t18-/m0/s1 LTTXWMUVGZRYLG-SFHVURJKSA-N 663636 US20240109912, Compound 9 Cyclin-dependent kinase 7 Homo sapiens 720 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663636&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396967 C=CC(=O)N1CC(C1)N1CC[C@H](C1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C25H30N6O3/c1-2-23(32)31-13-19(14-31)30-6-5-18(12-30)17-3-4-22-21(11-17)28-24-20(15-34-22)25(27-16-26-24)29-7-9-33-10-8-29/h2-4,11,16,18-19H,1,5-10,12-15H2,(H,26,27,28)/t18-/m1/s1 LTTXWMUVGZRYLG-GOSISDBHSA-N 663647 US20240109912, Compound 10 Cyclin-dependent kinase 7 Homo sapiens 380 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663647&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396968 CC1CC(CCN1C1CN(C1)C(=O)C=C)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C27H34N6O3/c1-3-25(34)32-14-21(15-32)33-7-6-20(12-18(33)2)19-4-5-24-23(13-19)30-26-22(16-36-24)27(29-17-28-26)31-8-10-35-11-9-31/h3-5,13,17-18,20-21H,1,6-12,14-16H2,2H3,(H,28,29,30) LHMXXSRBSZNOFV-UHFFFAOYSA-N 663648 US20240109912, Compound 34 Cyclin-dependent kinase 7 Homo sapiens 258 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663648&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396969 C=CC(=O)N1CC(C1)N1CCCC(C1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C26H32N6O3/c1-2-24(33)32-14-20(15-32)31-7-3-4-19(13-31)18-5-6-23-22(12-18)29-25-21(16-35-23)26(28-17-27-25)30-8-10-34-11-9-30/h2,5-6,12,17,19-20H,1,3-4,7-11,13-16H2,(H,27,28,29) AZRHRJIWKSBGME-UHFFFAOYSA-N 663649 US20240109912, Compound 35 Cyclin-dependent kinase 7 Homo sapiens 2046 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663649&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396970 C[C@H]1CN(CC[C@H]1c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-25(34)33-14-20(15-33)32-7-6-21(18(2)13-32)19-4-5-24-23(12-19)30-26-22(16-36-24)27(29-17-28-26)31-8-10-35-11-9-31/h3-5,12,17-18,20-21H,1,6-11,13-16H2,2H3,(H,28,29,30)/t18-,21+/m0/s1 AFXGNIOYFFFEDG-GHTZIAJQSA-N 663650 US20240109912, Compound 36 Cyclin-dependent kinase 7 Homo sapiens 80.3 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663650&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396971 C[C@H]1CN(CC[C@H]1c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-25(34)33-14-20(15-33)32-7-6-21(18(2)13-32)19-4-5-24-23(12-19)30-26-22(16-36-24)27(29-17-28-26)31-8-10-35-11-9-31/h3-5,12,17-18,20-21H,1,6-11,13-16H2,2H3,(H,28,29,30)/t18-,21+/m0/s1 AFXGNIOYFFFEDG-GHTZIAJQSA-N 663650 US20240109912, Compound 36 Cyclin-dependent kinase 7 Homo sapiens 233 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663650&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396972 C[C@@H]1CN(CC[C@@H]1c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-25(34)33-14-20(15-33)32-7-6-21(18(2)13-32)19-4-5-24-23(12-19)30-26-22(16-36-24)27(29-17-28-26)31-8-10-35-11-9-31/h3-5,12,17-18,20-21H,1,6-11,13-16H2,2H3,(H,28,29,30)/t18-,21+/m1/s1 AFXGNIOYFFFEDG-NQIIRXRSSA-N 663652 US20240109912, Compound 37 Cyclin-dependent kinase 7 Homo sapiens 164 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663652&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396973 C[C@@H]1CN(CC[C@@H]1c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-25(34)33-14-20(15-33)32-7-6-21(18(2)13-32)19-4-5-24-23(12-19)30-26-22(16-36-24)27(29-17-28-26)31-8-10-35-11-9-31/h3-5,12,17-18,20-21H,1,6-11,13-16H2,2H3,(H,28,29,30)/t18-,21+/m1/s1 AFXGNIOYFFFEDG-NQIIRXRSSA-N 663652 US20240109912, Compound 37 Cyclin-dependent kinase 7 Homo sapiens 152 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663652&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396974 C=CC(=O)N1CC(C1)N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C26H32N6O3/c1-2-24(33)32-14-20(15-32)30-7-5-18(6-8-30)19-3-4-23-22(13-19)29-25-21(16-35-23)26(28-17-27-25)31-9-11-34-12-10-31/h2-4,13,17-18,20H,1,5-12,14-16H2,(H,27,28,29) ICPULODQLPTLCI-UHFFFAOYSA-N 663653 US20240109912, Compound 1::US20240109912, Compound 38 Cyclin-dependent kinase 7 Homo sapiens 251 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663653&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396975 C=CC(=O)N1CC(C1)N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C26H32N6O3/c1-2-24(33)32-14-20(15-32)30-7-5-18(6-8-30)19-3-4-23-22(13-19)29-25-21(16-35-23)26(28-17-27-25)31-9-11-34-12-10-31/h2-4,13,17-18,20H,1,5-12,14-16H2,(H,27,28,29) ICPULODQLPTLCI-UHFFFAOYSA-N 663653 US20240109912, Compound 1::US20240109912, Compound 38 Cyclin-dependent kinase 7 Homo sapiens 0.389 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663653&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396976 C=CC(=O)N1CCC(CC1)N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C28H36N6O3/c1-2-26(35)33-11-7-22(8-12-33)32-9-5-20(6-10-32)21-3-4-25-24(17-21)31-27-23(18-37-25)28(30-19-29-27)34-13-15-36-16-14-34/h2-4,17,19-20,22H,1,5-16,18H2,(H,29,30,31) RBHZOZLSHGBBJR-UHFFFAOYSA-N 663663 US20240109912, Compound 2 Cyclin-dependent kinase 7 Homo sapiens 0.754 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663663&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396977 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)C1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-37-26)28(30-18-29-27)33-10-12-36-13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31) MSSHXJYIFHRYGN-UHFFFAOYSA-N 663694 US20240109912, Compound 11 Cyclin-dependent kinase 7 Homo sapiens 0.041 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663694&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396978 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-37-26)28(30-18-29-27)33-10-12-36-13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m0/s1 MSSHXJYIFHRYGN-QFIPXVFZSA-N 663695 US20240109912, Compound 12 Cyclin-dependent kinase 7 Homo sapiens 0.191 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663695&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396979 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-37-26)28(30-18-29-27)33-10-12-36-13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m1/s1 MSSHXJYIFHRYGN-JOCHJYFZSA-N 663696 US20240109912, Compound 13 Cyclin-dependent kinase 7 Homo sapiens 0.315 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663696&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396980 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-24(34)31-6-4-21(5-7-31)33-14-20(15-33)19-12-18(2)25-23(13-19)30-26-22(16-36-25)27(29-17-28-26)32-8-10-35-11-9-32/h3,12-13,17,20-21H,1,4-11,14-16H2,2H3,(H,28,29,30) DTUDIHMMKNRILP-UHFFFAOYSA-N 663697 US20240109912, Compound 14 Cyclin-dependent kinase 7 Homo sapiens 0.183 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663697&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396981 FC1CN(CCC1N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1)C(=O)C=C InChI=1S/C28H35FN6O3/c1-2-26(36)35-10-7-24(22(29)16-35)33-8-5-19(6-9-33)20-3-4-25-23(15-20)32-27-21(17-38-25)28(31-18-30-27)34-11-13-37-14-12-34/h2-4,15,18-19,22,24H,1,5-14,16-17H2,(H,30,31,32) RWPXBGIQDKSGIY-UHFFFAOYSA-N 663698 US20240109912, Compound 15 Cyclin-dependent kinase 7 Homo sapiens 0.632 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663698&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396982 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)C1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-35-24)26(28-16-27-25)30-6-8-34-9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29) LTFXXBRSJFMORH-UHFFFAOYSA-N 663699 US20240109912, Compound 16 Cyclin-dependent kinase 7 Homo sapiens 0.192 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663699&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396983 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-35-24)26(28-16-27-25)30-6-8-34-9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t20-/m1/s1 LTFXXBRSJFMORH-HXUWFJFHSA-N 663700 US20240109912, Compound 17 Cyclin-dependent kinase 7 Homo sapiens 0.716 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663700&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396984 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-35-24)26(28-16-27-25)30-6-8-34-9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t20-/m0/s1 LTFXXBRSJFMORH-FQEVSTJZSA-N 663701 US20240109912, Compound 18 Cyclin-dependent kinase 7 Homo sapiens 0.529 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663701&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396985 Clc1cc(cc2Nc3nccc(C4CCOCC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H33ClN4O3/c1-2-26(34)32-9-4-21(5-10-32)33-15-20(16-33)19-13-24(29)27-25(14-19)31-28-23(17-36-27)22(3-8-30-28)18-6-11-35-12-7-18/h2-3,8,13-14,18,20-21H,1,4-7,9-12,15-17H2,(H,30,31) RGKBMWZPRMUZKQ-UHFFFAOYSA-N 663702 US20240109912, Compound 19 Cyclin-dependent kinase 7 Homo sapiens 0.542 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663702&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396986 Fc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H31FN6O3/c1-2-23(34)33-13-19(14-33)31-5-3-17(4-6-31)18-11-21(27)24-22(12-18)30-25-20(15-36-24)26(29-16-28-25)32-7-9-35-10-8-32/h2,11-12,16-17,19H,1,3-10,13-15H2,(H,28,29,30) KPAIJPUQHOWCQN-UHFFFAOYSA-N 663703 US20240109912, Compound 20 Cyclin-dependent kinase 7 Homo sapiens 0.069 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663703&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396987 Cn1cc(cn1)-c1ncnc2Nc3cc(cc(F)c3OCc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H28FN7O2/c1-3-23(35)34-12-19(13-34)33-6-4-16(5-7-33)17-8-21(27)25-22(9-17)31-26-20(14-36-25)24(28-15-29-26)18-10-30-32(2)11-18/h3,8-11,15-16,19H,1,4-7,12-14H2,2H3,(H,28,29,31) IKWUUAGTLCGFQS-UHFFFAOYSA-N 663704 US20240109912, Compound 21 Cyclin-dependent kinase 7 Homo sapiens 0.408 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663704&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396988 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)[C@@H]1CCN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-3-23(33)32-13-20(14-32)31-5-4-18(12-31)19-10-17(2)24-22(11-19)29-25-21(15-35-24)26(28-16-27-25)30-6-8-34-9-7-30/h3,10-11,16,18,20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t18-/m1/s1 YOOMFOHCPQVZLX-GOSISDBHSA-N 663705 US20240109912, Compound 22 Cyclin-dependent kinase 7 Homo sapiens 0.208 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663705&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396989 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)[C@H]1CCN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-3-23(33)32-13-20(14-32)31-5-4-18(12-31)19-10-17(2)24-22(11-19)29-25-21(15-35-24)26(28-16-27-25)30-6-8-34-9-7-30/h3,10-11,16,18,20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t18-/m0/s1 YOOMFOHCPQVZLX-SFHVURJKSA-N 663706 US20240109912, Compound 23 Cyclin-dependent kinase 7 Homo sapiens 0.255 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663706&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396990 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)[C@H]1CCN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-25(35)32-8-5-22(6-9-32)34-7-4-20(16-34)21-14-19(2)26-24(15-21)31-27-23(17-37-26)28(30-18-29-27)33-10-12-36-13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t20-/m0/s1 FSQBYXGGLFJGBA-FQEVSTJZSA-N 663707 US20240109912, Compound 24 Cyclin-dependent kinase 7 Homo sapiens 0.533 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663707&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396991 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)[C@@H]1CCN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-25(35)32-8-5-22(6-9-32)34-7-4-20(16-34)21-14-19(2)26-24(15-21)31-27-23(17-37-26)28(30-18-29-27)33-10-12-36-13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t20-/m1/s1 FSQBYXGGLFJGBA-HXUWFJFHSA-N 663708 US20240109912, Compound 25 Cyclin-dependent kinase 7 Homo sapiens 1.22 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663708&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396992 C[C@@H]1Oc2c(F)cc(cc2Nc2ncnc(N3CCOCC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-23(35)32-6-4-20(5-7-32)34-14-19(15-34)18-12-21(28)25-22(13-18)31-26-24(17(2)37-25)27(30-16-29-26)33-8-10-36-11-9-33/h3,12-13,16-17,19-20H,1,4-11,14-15H2,2H3,(H,29,30,31)/t17-/m0/s1 UQBQULIOUXQMLG-KRWDZBQOSA-N 663709 US20240109912, Compound 26 Cyclin-dependent kinase 7 Homo sapiens 0.336 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663709&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396993 C[C@H]1Oc2c(F)cc(cc2Nc2ncnc(N3CCOCC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-23(35)32-6-4-20(5-7-32)34-14-19(15-34)18-12-21(28)25-22(13-18)31-26-24(17(2)37-25)27(30-16-29-26)33-8-10-36-11-9-33/h3,12-13,16-17,19-20H,1,4-11,14-15H2,2H3,(H,29,30,31)/t17-/m1/s1 UQBQULIOUXQMLG-QGZVFWFLSA-N 663710 US20240109912, Compound 27 Cyclin-dependent kinase 7 Homo sapiens 5.21 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663710&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396994 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)C1CCN(CC1F)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-24(35)33-5-4-23(21(28)14-33)34-12-19(13-34)18-10-17(2)25-22(11-18)31-26-20(15-37-25)27(30-16-29-26)32-6-8-36-9-7-32/h3,10-11,16,19,21,23H,1,4-9,12-15H2,2H3,(H,29,30,31) XYDZKLJSHDAMIM-UHFFFAOYSA-N 663711 US20240109912, Compound 28::US20240109912, Compound 29 Cyclin-dependent kinase 7 Homo sapiens 0.686 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663711&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396995 Cc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)C1CCN(CC1F)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-24(35)33-5-4-23(21(28)14-33)34-12-19(13-34)18-10-17(2)25-22(11-18)31-26-20(15-37-25)27(30-16-29-26)32-6-8-36-9-7-32/h3,10-11,16,19,21,23H,1,4-9,12-15H2,2H3,(H,29,30,31) XYDZKLJSHDAMIM-UHFFFAOYSA-N 663711 US20240109912, Compound 28::US20240109912, Compound 29 Cyclin-dependent kinase 7 Homo sapiens 0.780 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663711&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396996 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)[C@@H]1CCN(C1)C1CN(C1)C(=O)C=C InChI=1S/C25H31N7O4S/c1-3-22(33)32-12-18(13-32)31-5-4-17(11-31)20-10-21-23(16(2)28-20)36-14-19-24(29-21)26-15-27-25(19)30-6-8-37(34,35)9-7-30/h3,10,15,17-18H,1,4-9,11-14H2,2H3,(H,26,27,29)/t17-/m1/s1 QKZFFCPPZXGZFZ-QGZVFWFLSA-N 663713 US20240109912, Compound 30 Cyclin-dependent kinase 7 Homo sapiens 0.175 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663713&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396997 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)[C@H]1CCN(C1)C1CN(C1)C(=O)C=C InChI=1S/C25H31N7O4S/c1-3-22(33)32-12-18(13-32)31-5-4-17(11-31)20-10-21-23(16(2)28-20)36-14-19-24(29-21)26-15-27-25(19)30-6-8-37(34,35)9-7-30/h3,10,15,17-18H,1,4-9,11-14H2,2H3,(H,26,27,29)/t17-/m0/s1 QKZFFCPPZXGZFZ-KRWDZBQOSA-N 663714 US20240109912, Compound 31 Cyclin-dependent kinase 7 Homo sapiens 0.226 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663714&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396998 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)34-15-22(16-34)32-7-5-20(6-8-32)21-13-18(2)26-23(14-21)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19-20,22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 GEJQJTGWWUQEMM-IBGZPJMESA-N 663715 US20240109912, Compound 32 Cyclin-dependent kinase 7 Homo sapiens 0.025 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663715&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1396999 C=CC(=O)N1CC(C1)N1CCC(CC1)c1ccc2OCc3c(Nc2c1)ncnc3C1=CCOCC1 InChI=1S/C27H31N5O3/c1-2-25(33)32-14-21(15-32)31-9-5-18(6-10-31)20-3-4-24-23(13-20)30-27-22(16-35-24)26(28-17-29-27)19-7-11-34-12-8-19/h2-4,7,13,17-18,21H,1,5-6,8-12,14-16H2,(H,28,29,30) QZPKLHBVUFIDDQ-UHFFFAOYSA-N 663716 US20240109912, Compound 39 Cyclin-dependent kinase 7 Homo sapiens 0.610 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663716&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397000 C=CC(=O)N1CC(C1)N1C2CCC1CC(C2)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C28H34N6O3/c1-2-26(35)33-14-22(15-33)34-20-4-5-21(34)12-19(11-20)18-3-6-25-24(13-18)31-27-23(16-37-25)28(30-17-29-27)32-7-9-36-10-8-32/h2-3,6,13,17,19-22H,1,4-5,7-12,14-16H2,(H,29,30,31) HFFGRURHGSPEQY-UHFFFAOYSA-N 663717 US20240109912, Compound 40::US20240109912, Compound 41 Cyclin-dependent kinase 7 Homo sapiens 0.160 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397001 C=CC(=O)N1CC(C1)N1C2CCC1CC(C2)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C28H34N6O3/c1-2-26(35)33-14-22(15-33)34-20-4-5-21(34)12-19(11-20)18-3-6-25-24(13-18)31-27-23(16-37-25)28(30-17-29-27)32-7-9-36-10-8-32/h2-3,6,13,17,19-22H,1,4-5,7-12,14-16H2,(H,29,30,31) HFFGRURHGSPEQY-UHFFFAOYSA-N 663717 US20240109912, Compound 40::US20240109912, Compound 41 Cyclin-dependent kinase 7 Homo sapiens 0.991 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397002 C=CC(=O)N1CC(C1)N1C2CCC1CC(C2)c1ccc2OCc3c(Nc2c1)ncnc3N1CCOCC1 InChI=1S/C28H34N6O3/c1-2-26(35)33-14-22(15-33)34-20-4-5-21(34)12-19(11-20)18-3-6-25-24(13-18)31-27-23(16-37-25)28(30-17-29-27)32-7-9-36-10-8-32/h2-3,6,13,17,19-22H,1,4-5,7-12,14-16H2,(H,29,30,31) HFFGRURHGSPEQY-UHFFFAOYSA-N 663717 US20240109912, Compound 40::US20240109912, Compound 41 Cyclin-dependent kinase 7 Homo sapiens 0.898 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663717&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397003 Clc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H31ClN6O3/c1-2-23(34)33-13-19(14-33)31-5-3-17(4-6-31)18-11-21(27)24-22(12-18)30-25-20(15-36-24)26(29-16-28-25)32-7-9-35-10-8-32/h2,11-12,16-17,19H,1,3-10,13-15H2,(H,28,29,30) QULYCMCFQOHYJK-UHFFFAOYSA-N 663719 US20240109912, Compound 42 Cyclin-dependent kinase 7 Homo sapiens 0.028 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663719&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397004 Cn1cc(cn1)-c1ncnc2Nc3cc(cc(c3OCc12)C(F)(F)F)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H28F3N7O2/c1-3-23(38)36-6-4-19(5-7-36)37-12-18(13-37)16-8-21(27(28,29)30)25-22(9-16)34-26-20(14-39-25)24(31-15-32-26)17-10-33-35(2)11-17/h3,8-11,15,18-19H,1,4-7,12-14H2,2H3,(H,31,32,34) KIYUJLUCOOHKOV-UHFFFAOYSA-N 663720 US20240109912, Compound 44 Cyclin-dependent kinase 7 Homo sapiens 0.670 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663720&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397005 FC(F)(F)c1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H31F3N6O3/c1-2-23(37)34-5-3-19(4-6-34)36-13-18(14-36)17-11-21(27(28,29)30)24-22(12-17)33-25-20(15-39-24)26(32-16-31-25)35-7-9-38-10-8-35/h2,11-12,16,18-19H,1,3-10,13-15H2,(H,31,32,33) QKBVAIJJBNHIFS-UHFFFAOYSA-N 663721 US20240109912, Compound 45 Cyclin-dependent kinase 7 Homo sapiens 0.219 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663721&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397006 C[C@H]1Oc2c(F)cc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-23(35)34-14-20(15-34)32-6-4-18(5-7-32)19-12-21(28)25-22(13-19)31-26-24(17(2)37-25)27(30-16-29-26)33-8-10-36-11-9-33/h3,12-13,16-18,20H,1,4-11,14-15H2,2H3,(H,29,30,31)/t17-/m1/s1 HUARBMDJPPMODG-QGZVFWFLSA-N 663722 US20240109912, Compound 46 Cyclin-dependent kinase 7 Homo sapiens 0.094 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663722&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397007 C=CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2c(c1)C1CC1 InChI=1S/C29H36N6O3/c1-2-26(36)35-15-22(16-35)33-7-5-19(6-8-33)21-13-23(20-3-4-20)27-25(14-21)32-28-24(17-38-27)29(31-18-30-28)34-9-11-37-12-10-34/h2,13-14,18-20,22H,1,3-12,15-17H2,(H,30,31,32) MZTYSDXEOAQAIL-UHFFFAOYSA-N 663723 US20240109912, Compound 47 Cyclin-dependent kinase 7 Homo sapiens 0.175 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663723&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397008 C=CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2cn1 InChI=1S/C25H31N7O3/c1-2-23(33)32-13-18(14-32)30-5-3-17(4-6-30)20-11-21-22(12-26-20)35-15-19-24(29-21)27-16-28-25(19)31-7-9-34-10-8-31/h2,11-12,16-18H,1,3-10,13-15H2,(H,27,28,29) NFZGWDFZXQYOCK-UHFFFAOYSA-N 663724 US20240109912, Compound 48 Cyclin-dependent kinase 7 Homo sapiens 0.232 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663724&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397009 C[C@@H]1Oc2c(F)cc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-3-23(35)34-14-20(15-34)32-6-4-18(5-7-32)19-12-21(28)25-22(13-19)31-26-24(17(2)37-25)27(30-16-29-26)33-8-10-36-11-9-33/h3,12-13,16-18,20H,1,4-11,14-15H2,2H3,(H,29,30,31)/t17-/m0/s1 HUARBMDJPPMODG-KRWDZBQOSA-N 663725 US20240109912, Compound 49 Cyclin-dependent kinase 7 Homo sapiens 0.118 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663725&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397010 Fc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-2-24(35)34-8-5-20(15-34)32-6-3-18(4-7-32)19-13-22(28)25-23(14-19)31-26-21(16-37-25)27(30-17-29-26)33-9-11-36-12-10-33/h2,13-14,17-18,20H,1,3-12,15-16H2,(H,29,30,31)/t20-/m0/s1 FJICDEWIBDHCAW-FQEVSTJZSA-N 663726 US20240109912, Compound 50 Cyclin-dependent kinase 7 Homo sapiens 0.302 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663726&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397011 Fc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CCN(CC1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H33FN6O3/c1-2-24(35)34-8-5-20(15-34)32-6-3-18(4-7-32)19-13-22(28)25-23(14-19)31-26-21(16-37-25)27(30-17-29-26)33-9-11-36-12-10-33/h2,13-14,17-18,20H,1,3-12,15-16H2,(H,29,30,31)/t20-/m1/s1 FJICDEWIBDHCAW-HXUWFJFHSA-N 663727 US20240109912, Compound 51 Cyclin-dependent kinase 7 Homo sapiens 0.643 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663727&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397012 C[C@H]1Oc2c(F)cc(cc2Nc2ncnc(-c3cnn(C)c3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H30FN7O2/c1-4-23(36)35-13-20(14-35)34-7-5-17(6-8-34)18-9-21(28)26-22(10-18)32-27-24(16(2)37-26)25(29-15-30-27)19-11-31-33(3)12-19/h4,9-12,15-17,20H,1,5-8,13-14H2,2-3H3,(H,29,30,32)/t16-/m1/s1 VKJOGUNCTILGBB-MRXNPFEDSA-N 663728 US20240109912, Compound 52 Cyclin-dependent kinase 7 Homo sapiens 0.083 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663728&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397013 Fc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C25H29FN6O3/c1-2-22(33)31-4-3-18(13-31)32-11-17(12-32)16-9-20(26)23-21(10-16)29-24-19(14-35-23)25(28-15-27-24)30-5-7-34-8-6-30/h2,9-10,15,17-18H,1,3-8,11-14H2,(H,27,28,29)/t18-/m0/s1 OXIJHTUPJBDYFP-SFHVURJKSA-N 663729 US20240109912, Compound 54 Cyclin-dependent kinase 7 Homo sapiens 1.36 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663729&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397014 Fc1cc(cc2Nc3ncnc(N4CCOCC4)c3COc12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C25H29FN6O3/c1-2-22(33)31-4-3-18(13-31)32-11-17(12-32)16-9-20(26)23-21(10-16)29-24-19(14-35-23)25(28-15-27-24)30-5-7-34-8-6-30/h2,9-10,15,17-18H,1,3-8,11-14H2,(H,27,28,29)/t18-/m1/s1 OXIJHTUPJBDYFP-GOSISDBHSA-N 663730 US20240109912, Compound 55 Cyclin-dependent kinase 7 Homo sapiens 1.04 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663730&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397015 C[C@H]1Oc2ccc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-24(34)33-15-21(16-33)31-8-6-19(7-9-31)20-4-5-23-22(14-20)30-26-25(18(2)36-23)27(29-17-28-26)32-10-12-35-13-11-32/h3-5,14,17-19,21H,1,6-13,15-16H2,2H3,(H,28,29,30)/t18-/m1/s1 NQURTOOKNXGNKG-GOSISDBHSA-N 663731 US20240109912, Compound 56 Cyclin-dependent kinase 7 Homo sapiens 4.20 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663731&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397016 C[C@@H]1Oc2ccc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-24(34)33-15-21(16-33)31-8-6-19(7-9-31)20-4-5-23-22(14-20)30-26-25(18(2)36-23)27(29-17-28-26)32-10-12-35-13-11-32/h3-5,14,17-19,21H,1,6-13,15-16H2,2H3,(H,28,29,30)/t18-/m0/s1 NQURTOOKNXGNKG-SFHVURJKSA-N 663732 US20240109912, Compound 57 Cyclin-dependent kinase 7 Homo sapiens 0.088 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663732&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397017 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H33N7O4S/c1-3-23(34)33-13-19(14-33)31-6-4-18(5-7-31)21-12-22-24(17(2)29-21)37-15-20-25(30-22)27-16-28-26(20)32-8-10-38(35,36)11-9-32/h3,12,16,18-19H,1,4-11,13-15H2,2H3,(H,27,28,30) AWYQXGAYFJFDOX-UHFFFAOYSA-N 663733 US20240109912, Compound 58 Cyclin-dependent kinase 7 Homo sapiens 0.045 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663733&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397018 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H37N7O4S/c1-3-25(36)34-10-6-21(7-11-34)33-8-4-20(5-9-33)23-16-24-26(19(2)31-23)39-17-22-27(32-24)29-18-30-28(22)35-12-14-40(37,38)15-13-35/h3,16,18,20-21H,1,4-15,17H2,2H3,(H,29,30,32) KUDKFWHSZJFGGE-UHFFFAOYSA-N 663734 US20240109912, Compound 59 Cyclin-dependent kinase 7 Homo sapiens 0.071 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663734&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397019 C[C@H]1Oc2cnc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H33N7O3/c1-3-23(34)33-14-19(15-33)31-6-4-18(5-7-31)20-12-21-22(13-27-20)36-17(2)24-25(30-21)28-16-29-26(24)32-8-10-35-11-9-32/h3,12-13,16-19H,1,4-11,14-15H2,2H3,(H,28,29,30)/t17-/m1/s1 QOWNOTMWUWWPAP-QGZVFWFLSA-N 663735 US20240109912, Compound 60::US20240109912, Compound 83 Cyclin-dependent kinase 7 Homo sapiens 0.283 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663735&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397020 C=CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2cc1C#N InChI=1S/C27H31N7O3/c1-2-25(35)34-14-20(15-34)32-5-3-18(4-6-32)21-12-23-24(11-19(21)13-28)37-16-22-26(31-23)29-17-30-27(22)33-7-9-36-10-8-33/h2,11-12,17-18,20H,1,3-10,14-16H2,(H,29,30,31) DOFQNCKNOBGITA-UHFFFAOYSA-N 663736 US20240109912, Compound 61 Cyclin-dependent kinase 7 Homo sapiens 0.830 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663736&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397021 C[C@@H]1Oc2cnc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H33N7O3/c1-3-23(34)33-14-19(15-33)31-6-4-18(5-7-31)20-12-21-22(13-27-20)36-17(2)24-25(30-21)28-16-29-26(24)32-8-10-35-11-9-32/h3,12-13,16-19H,1,4-11,14-15H2,2H3,(H,28,29,30)/t17-/m0/s1 QOWNOTMWUWWPAP-KRWDZBQOSA-N 663737 US20240109912, Compound 62 Cyclin-dependent kinase 7 Homo sapiens 0.504 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663737&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397022 C[C@@H]1Oc2cnc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H33N7O3/c1-3-23(34)33-14-19(15-33)31-6-4-18(5-7-31)20-12-21-22(13-27-20)36-17(2)24-25(30-21)28-16-29-26(24)32-8-10-35-11-9-32/h3,12-13,16-19H,1,4-11,14-15H2,2H3,(H,28,29,30)/t17-/m0/s1 QOWNOTMWUWWPAP-KRWDZBQOSA-N 663737 US20240109912, Compound 62 Cyclin-dependent kinase 7 Homo sapiens 2.05 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663737&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397023 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C26H33N7O4S/c1-3-23(34)31-6-4-19(5-7-31)33-13-18(14-33)21-12-22-24(17(2)29-21)37-15-20-25(30-22)27-16-28-26(20)32-8-10-38(35,36)11-9-32/h3,12,16,18-19H,1,4-11,13-15H2,2H3,(H,27,28,30) VFESXLIMCBVLEW-UHFFFAOYSA-N 663738 US20240109912, Compound 63 Cyclin-dependent kinase 7 Homo sapiens 0.174 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663738&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397024 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CN(C1)C(=O)C=C InChI=1S/C24H29N7O4S/c1-3-21(32)31-11-17(12-31)30-9-16(10-30)19-8-20-22(15(2)27-19)35-13-18-23(28-20)25-14-26-24(18)29-4-6-36(33,34)7-5-29/h3,8,14,16-17H,1,4-7,9-13H2,2H3,(H,25,26,28) GGUPTGRDCNVJCH-UHFFFAOYSA-N 663739 US20240109912, Compound 64 Cyclin-dependent kinase 7 Homo sapiens 0.427 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663739&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397025 Cc1cc(cc2Nc3ncnc(N4CCC(C4)S(C)(=O)=O)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-25(35)34-13-21(14-34)32-8-5-19(6-9-32)20-11-18(2)26-24(12-20)31-27-23(16-38-26)28(30-17-29-27)33-10-7-22(15-33)39(3,36)37/h4,11-12,17,19,21-22H,1,5-10,13-16H2,2-3H3,(H,29,30,31) NBLFFXPLVGFAJO-UHFFFAOYSA-N 663740 US20240109912, Compound 65 Cyclin-dependent kinase 7 Homo sapiens 4.12 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663740&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397026 CCC1Oc2ccc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-23-26-27(29-18-30-28(26)33-11-13-36-14-12-33)31-22-15-20(5-6-24(22)37-23)19-7-9-32(10-8-19)21-16-34(17-21)25(35)4-2/h4-6,15,18-19,21,23H,2-3,7-14,16-17H2,1H3,(H,29,30,31) NHBWWEQFXUHMJJ-UHFFFAOYSA-N 663741 US20240109912, Compound 66 Cyclin-dependent kinase 7 Homo sapiens 0.528 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663741&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397027 Cc1cc(cc2Nc3ncnc(N4CCCC(C4)C#N)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C29H35N7O2/c1-3-26(37)36-15-23(16-36)34-9-6-21(7-10-34)22-11-19(2)27-25(12-22)33-28-24(17-38-27)29(32-18-31-28)35-8-4-5-20(13-30)14-35/h3,11-12,18,20-21,23H,1,4-10,14-17H2,2H3,(H,31,32,33) WBDHSIKQLVBOFZ-UHFFFAOYSA-N 663742 US20240109912, Compound 67 Cyclin-dependent kinase 7 Homo sapiens 1.20 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663742&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397028 Cc1cc(cc2Nc3ncnc(N4CCOC5(COC5)C4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C29H36N6O4/c1-3-25(36)35-12-22(13-35)33-6-4-20(5-7-33)21-10-19(2)26-24(11-21)32-27-23(14-38-26)28(31-18-30-27)34-8-9-39-29(15-34)16-37-17-29/h3,10-11,18,20,22H,1,4-9,12-17H2,2H3,(H,30,31,32) POQWXCHYONFIJR-UHFFFAOYSA-N 663743 US20240109912, Compound 68 Cyclin-dependent kinase 7 Homo sapiens 0.042 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663743&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397029 Cc1cc(cc2Nc3ncnc(N4CCC(CC4)C#N)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C29H35N7O2/c1-3-26(37)36-15-23(16-36)34-10-6-21(7-11-34)22-12-19(2)27-25(13-22)33-28-24(17-38-27)29(32-18-31-28)35-8-4-20(14-30)5-9-35/h3,12-13,18,20-21,23H,1,4-11,15-17H2,2H3,(H,31,32,33) WWIDOMQGPWFLCT-UHFFFAOYSA-N 663744 US20240109912, Compound 69 Cyclin-dependent kinase 7 Homo sapiens 1.10 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663744&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397030 Cc1cc(cc2Nc3ncnc(N4CCC(CC4)S(C)(=O)=O)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C29H38N6O4S/c1-4-26(36)35-15-22(16-35)33-9-5-20(6-10-33)21-13-19(2)27-25(14-21)32-28-24(17-39-27)29(31-18-30-28)34-11-7-23(8-12-34)40(3,37)38/h4,13-14,18,20,22-23H,1,5-12,15-17H2,2-3H3,(H,30,31,32) KOZZWTAXXNQZMQ-UHFFFAOYSA-N 663745 US20240109912, Compound 70 Cyclin-dependent kinase 7 Homo sapiens 53.0 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663745&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397031 C=CC(=O)N1CC(C1)N1CCN(CC1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2cn1 InChI=1S/C24H30N8O3/c1-2-22(33)32-13-17(14-32)29-3-5-30(6-4-29)21-11-19-20(12-25-21)35-15-18-23(28-19)26-16-27-24(18)31-7-9-34-10-8-31/h2,11-12,16-17H,1,3-10,13-15H2,(H,26,27,28) PWCMZOVWDGYASV-UHFFFAOYSA-N 663746 US20240109912, Compound 71 Cyclin-dependent kinase 7 Homo sapiens 3.20 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663746&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397032 Cn1cc(cn1)-c1ncnc2Nc3cc(cc(C#N)c3OCc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H28N8O2/c1-3-24(36)34-6-4-21(5-7-34)35-13-20(14-35)17-8-18(10-28)26-23(9-17)32-27-22(15-37-26)25(29-16-30-27)19-11-31-33(2)12-19/h3,8-9,11-12,16,20-21H,1,4-7,13-15H2,2H3,(H,29,30,32) SEWYMRKCSQLNEN-UHFFFAOYSA-N 663747 US20240109912, Compound 73 Cyclin-dependent kinase 7 Homo sapiens 1.24 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663747&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397033 Cn1cc(cn1)-c1ncnc2Nc3cc(cc(C#N)c3OCc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H28N8O2/c1-3-24(36)35-13-21(14-35)34-6-4-17(5-7-34)18-8-19(10-28)26-23(9-18)32-27-22(15-37-26)25(29-16-30-27)20-11-31-33(2)12-20/h3,8-9,11-12,16-17,21H,1,4-7,13-15H2,2H3,(H,29,30,32) KRXRYSAYDWREEV-UHFFFAOYSA-N 663748 US20240109912, Compound 74 Cyclin-dependent kinase 7 Homo sapiens 0.132 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663748&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397034 CC[C@@H]1Oc2ccc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-23-26-27(29-18-30-28(26)33-11-13-36-14-12-33)31-22-15-20(5-6-24(22)37-23)19-7-9-32(10-8-19)21-16-34(17-21)25(35)4-2/h4-6,15,18-19,21,23H,2-3,7-14,16-17H2,1H3,(H,29,30,31)/t23-/m0/s1 NHBWWEQFXUHMJJ-QHCPKHFHSA-N 663749 US20240109912, Compound 75 Cyclin-dependent kinase 7 Homo sapiens 0.265 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663749&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397035 CC[C@H]1Oc2ccc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O3/c1-3-23-26-27(29-18-30-28(26)33-11-13-36-14-12-33)31-22-15-20(5-6-24(22)37-23)19-7-9-32(10-8-19)21-16-34(17-21)25(35)4-2/h4-6,15,18-19,21,23H,2-3,7-14,16-17H2,1H3,(H,29,30,31)/t23-/m1/s1 NHBWWEQFXUHMJJ-HSZRJFAPSA-N 663750 US20240109912, Compound 76 Cyclin-dependent kinase 7 Homo sapiens 0.457 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663750&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397036 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CCN(C1)C(=O)C=C InChI=1S/C25H31N7O4S/c1-3-22(33)31-5-4-18(13-31)32-11-17(12-32)20-10-21-23(16(2)28-20)36-14-19-24(29-21)26-15-27-25(19)30-6-8-37(34,35)9-7-30/h3,10,15,17-18H,1,4-9,11-14H2,2H3,(H,26,27,29) LWTXBULJTKLKRB-UHFFFAOYSA-N 663751 US20240109912, Compound 77 Cyclin-dependent kinase 7 Homo sapiens 0.172 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663751&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397037 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C25H31N7O4S/c1-3-22(33)31-5-4-18(13-31)32-11-17(12-32)20-10-21-23(16(2)28-20)36-14-19-24(29-21)26-15-27-25(19)30-6-8-37(34,35)9-7-30/h3,10,15,17-18H,1,4-9,11-14H2,2H3,(H,26,27,29)/t18-/m0/s1 LWTXBULJTKLKRB-SFHVURJKSA-N 663752 US20240109912, Compound 78 Cyclin-dependent kinase 7 Homo sapiens 0.168 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663752&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397038 Cc1nc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C25H31N7O4S/c1-3-22(33)31-5-4-18(13-31)32-11-17(12-32)20-10-21-23(16(2)28-20)36-14-19-24(29-21)26-15-27-25(19)30-6-8-37(34,35)9-7-30/h3,10,15,17-18H,1,4-9,11-14H2,2H3,(H,26,27,29)/t18-/m1/s1 LWTXBULJTKLKRB-GOSISDBHSA-N 663753 US20240109912, Compound 79 Cyclin-dependent kinase 7 Homo sapiens 0.189 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663753&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397039 Cc1cc(cc2Nc3ncnc(-c4ccnn4C)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H31N7O2/c1-4-24(35)34-13-20(14-34)33-9-6-18(7-10-33)19-11-17(2)26-22(12-19)31-27-21(15-36-26)25(28-16-29-27)23-5-8-30-32(23)3/h4-5,8,11-12,16,18,20H,1,6-7,9-10,13-15H2,2-3H3,(H,28,29,31) YJMLEVFNECVFAF-UHFFFAOYSA-N 663754 US20240109912, Compound 80 Cyclin-dependent kinase 7 Homo sapiens 0.320 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663754&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397040 Cc1nn(C)cc1-c1ncnc2Nc3cc(cc(C)c3OCc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H33N7O2/c1-5-25(36)35-12-21(13-35)34-8-6-19(7-9-34)20-10-17(2)27-24(11-20)31-28-23(15-37-27)26(29-16-30-28)22-14-33(4)32-18(22)3/h5,10-11,14,16,19,21H,1,6-9,12-13,15H2,2-4H3,(H,29,30,31) PRTYAELXDMOTJE-UHFFFAOYSA-N 663755 US20240109912, Compound 81 Cyclin-dependent kinase 7 Homo sapiens 0.310 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663755&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397041 CCOc1cncc(c1)-c1ncnc2Nc3cc(cc(C)c3OCc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C30H34N6O3/c1-4-27(37)36-15-23(16-36)35-8-6-20(7-9-35)21-10-19(3)29-26(12-21)34-30-25(17-39-29)28(32-18-33-30)22-11-24(38-5-2)14-31-13-22/h4,10-14,18,20,23H,1,5-9,15-17H2,2-3H3,(H,32,33,34) FGJJURIJHURLBH-UHFFFAOYSA-N 663756 US20240109912, Compound 82 Cyclin-dependent kinase 7 Homo sapiens 1.28 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663756&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397042 C[C@H]1Oc2cnc(cc2Nc2ncnc(N3CCOCC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C26H33N7O3/c1-3-23(34)33-14-19(15-33)31-6-4-18(5-7-31)20-12-21-22(13-27-20)36-17(2)24-25(30-21)28-16-29-26(24)32-8-10-35-11-9-32/h3,12-13,16-19H,1,4-11,14-15H2,2H3,(H,28,29,30)/t17-/m1/s1 QOWNOTMWUWWPAP-QGZVFWFLSA-N 663735 US20240109912, Compound 60::US20240109912, Compound 83 Cyclin-dependent kinase 7 Homo sapiens 0.059 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663735&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397043 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)34-15-22(16-34)32-7-5-20(6-8-32)21-13-18(2)26-23(14-21)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19-20,22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m1/s1 GEJQJTGWWUQEMM-LJQANCHMSA-N 663758 US20240109912, Compound 84 Cyclin-dependent kinase 7 Homo sapiens 0.148 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663758&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397044 C[C@@H]1Oc2c(C)nc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H35N7O4S/c1-4-23(35)34-14-20(15-34)32-7-5-19(6-8-32)21-13-22-25(17(2)30-21)38-18(3)24-26(31-22)28-16-29-27(24)33-9-11-39(36,37)12-10-33/h4,13,16,18-20H,1,5-12,14-15H2,2-3H3,(H,28,29,31)/t18-/m0/s1 ZNCHZSNHHGRFFG-SFHVURJKSA-N 663759 US20240109912, Compound 86 Cyclin-dependent kinase 7 Homo sapiens 0.117 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663759&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397045 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-3-24(34)31-6-4-21(5-7-31)33-14-20(15-33)19-12-18(2)25-23(13-19)30-26-22(16-37-25)27(29-17-28-26)32-8-10-38(35,36)11-9-32/h3,12-13,17,20-21H,1,4-11,14-16H2,2H3,(H,28,29,30) JOTDPIWQXVRTOK-UHFFFAOYSA-N 663760 US20240109912, Compound 87 Cyclin-dependent kinase 7 Homo sapiens 0.234 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663760&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397046 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)C1CCN(CC1)C(=O)C=C InChI=1S/C29H38N6O4S/c1-3-26(36)34-10-6-23(7-11-34)33-8-4-21(5-9-33)22-16-20(2)27-25(17-22)32-28-24(18-39-27)29(31-19-30-28)35-12-14-40(37,38)15-13-35/h3,16-17,19,21,23H,1,4-15,18H2,2H3,(H,30,31,32) ZTVQYQCGSRANSJ-UHFFFAOYSA-N 663761 US20240109912, Compound 88 Cyclin-dependent kinase 7 Homo sapiens 0.049 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663761&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397047 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)N1CCN(CC1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H37N7O4S/c1-3-25(36)34-6-4-21(5-7-34)32-8-10-33(11-9-32)22-16-20(2)26-24(17-22)31-27-23(18-39-26)28(30-19-29-27)35-12-14-40(37,38)15-13-35/h3,16-17,19,21H,1,4-15,18H2,2H3,(H,29,30,31) JTOJBXJRQVJLAY-UHFFFAOYSA-N 663762 US20240109912, Compound 89 Cyclin-dependent kinase 7 Homo sapiens 0.128 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663762&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397048 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O4S/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-36-24)26(28-16-27-25)30-6-8-37(34,35)9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t20-/m0/s1 WLPODHXWFLIJEV-FQEVSTJZSA-N 663763 US20240109912, Compound 90 Cyclin-dependent kinase 7 Homo sapiens 0.110 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663763&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397049 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)N1CCC(CC1)N1CCN(CC1)C(=O)C=C InChI=1S/C28H37N7O4S/c1-3-25(36)34-10-8-33(9-11-34)21-4-6-32(7-5-21)22-16-20(2)26-24(17-22)31-27-23(18-39-26)28(30-19-29-27)35-12-14-40(37,38)15-13-35/h3,16-17,19,21H,1,4-15,18H2,2H3,(H,29,30,31) LQWBBSMIKBHHJM-UHFFFAOYSA-N 663764 US20240109912, Compound 91 Cyclin-dependent kinase 7 Homo sapiens 0.041 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663764&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397050 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O4S/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-36-24)26(28-16-27-25)30-6-8-37(34,35)9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29)/t20-/m1/s1 WLPODHXWFLIJEV-HXUWFJFHSA-N 663765 US20240109912, Compound 92 Cyclin-dependent kinase 7 Homo sapiens 0.100 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663765&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397051 C=CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc2c(c1)C1CC1 InChI=1S/C28H34N6O4S/c1-2-25(35)33-6-5-21(15-33)34-13-20(14-34)19-11-22(18-3-4-18)26-24(12-19)31-27-23(16-38-26)28(30-17-29-27)32-7-9-39(36,37)10-8-32/h2,11-12,17-18,20-21H,1,3-10,13-16H2,(H,29,30,31)/t21-/m1/s1 GWBQEIOUPISLJC-OAQYLSRUSA-N 663766 US20240109912, Compound 93 Cyclin-dependent kinase 7 Homo sapiens 0.277 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663766&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397052 C=CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc2c(c1)C1CC1 InChI=1S/C28H34N6O4S/c1-2-25(35)33-6-5-21(15-33)34-13-20(14-34)19-11-22(18-3-4-18)26-24(12-19)31-27-23(16-38-26)28(30-17-29-27)32-7-9-39(36,37)10-8-32/h2,11-12,17-18,20-21H,1,3-10,13-16H2,(H,29,30,31)/t21-/m0/s1 GWBQEIOUPISLJC-NRFANRHFSA-N 663767 US20240109912, Compound 94 Cyclin-dependent kinase 7 Homo sapiens 0.498 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663767&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397053 C[C@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C1CC1)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C29H36N6O4S/c1-3-25(36)34-7-6-22(16-34)35-14-21(15-35)20-12-23(19-4-5-19)27-24(13-20)32-28-26(18(2)39-27)29(31-17-30-28)33-8-10-40(37,38)11-9-33/h3,12-13,17-19,21-22H,1,4-11,14-16H2,2H3,(H,30,31,32)/t18-,22+/m1/s1 LFBZELDFKFUREF-GCJKJVERSA-N 663768 US20240109912, Compound 95 Cyclin-dependent kinase 7 Homo sapiens 0.071 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663768&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397054 C[C@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C1CC1)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C29H36N6O4S/c1-3-25(36)34-7-6-22(16-34)35-14-21(15-35)20-12-23(19-4-5-19)27-24(13-20)32-28-26(18(2)39-27)29(31-17-30-28)33-8-10-40(37,38)11-9-33/h3,12-13,17-19,21-22H,1,4-11,14-16H2,2H3,(H,30,31,32)/t18-,22-/m1/s1 LFBZELDFKFUREF-XMSQKQJNSA-N 663769 US20240109912, Compound 96 Cyclin-dependent kinase 7 Homo sapiens 0.032 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663769&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397055 C[C@@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C1CC1)C1CN(C1)C1CCN(C1)C(=O)C=C InChI=1S/C29H36N6O4S/c1-3-25(36)34-7-6-22(16-34)35-14-21(15-35)20-12-23(19-4-5-19)27-24(13-20)32-28-26(18(2)39-27)29(31-17-30-28)33-8-10-40(37,38)11-9-33/h3,12-13,17-19,21-22H,1,4-11,14-16H2,2H3,(H,30,31,32)/t18-,22?/m0/s1 LFBZELDFKFUREF-HXBUSHRASA-N 663770 US20240109912, Compound 97 Cyclin-dependent kinase 7 Homo sapiens 0.007 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663770&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397056 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 HPQYTHYHWCTDRA-IBGZPJMESA-N 663771 US20240109912, Compound 100 Cyclin-dependent kinase 7 Homo sapiens 0.081 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663771&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397057 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 HPQYTHYHWCTDRA-IBGZPJMESA-N 663771 US20240109912, Compound 100 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663771&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397058 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 HPQYTHYHWCTDRA-IBGZPJMESA-N 663771 US20240109912, Compound 100 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663771&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397059 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 HPQYTHYHWCTDRA-IBGZPJMESA-N 663771 US20240109912, Compound 100 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663771&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397060 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m0/s1 HPQYTHYHWCTDRA-IBGZPJMESA-N 663771 US20240109912, Compound 100 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663771&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397061 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-3-24(34)33-14-21(15-33)31-6-4-19(5-7-31)20-12-18(2)25-23(13-20)30-26-22(16-37-25)27(29-17-28-26)32-8-10-38(35,36)11-9-32/h3,12-13,17,19,21H,1,4-11,14-16H2,2H3,(H,28,29,30) VHUQAUUGVZWHRX-UHFFFAOYSA-N 663772 US20240109912, Compound 101 Cyclin-dependent kinase 7 Homo sapiens 0.077 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663772&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397062 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-3-24(34)33-14-21(15-33)31-6-4-19(5-7-31)20-12-18(2)25-23(13-20)30-26-22(16-37-25)27(29-17-28-26)32-8-10-38(35,36)11-9-32/h3,12-13,17,19,21H,1,4-11,14-16H2,2H3,(H,28,29,30) VHUQAUUGVZWHRX-UHFFFAOYSA-N 663772 US20240109912, Compound 101 Cyclin-dependent kinase 7 Homo sapiens 0.032 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663772&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397063 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m1/s1 HPQYTHYHWCTDRA-LJQANCHMSA-N 663773 US20240109912, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 0.532 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397064 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m1/s1 HPQYTHYHWCTDRA-LJQANCHMSA-N 663773 US20240109912, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 0.504 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397065 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m1/s1 HPQYTHYHWCTDRA-LJQANCHMSA-N 663773 US20240109912, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 0.504 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397066 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-4-24(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-18(2)26-23(14-20)31-27-25(19(3)38-26)28(30-17-29-27)33-9-11-39(36,37)12-10-33/h4,13-14,17,19,21-22H,1,5-12,15-16H2,2-3H3,(H,29,30,31)/t19-/m1/s1 HPQYTHYHWCTDRA-LJQANCHMSA-N 663773 US20240109912, Compound 102 Cyclin-dependent kinase 7 Homo sapiens 0.504 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663773&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397067 CC1Oc2c(C)cc(cc2Nc2ncnc(N3CCOCC3)c12)C1CN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H32N6O3/c1-4-22(33)32-13-20(14-32)31-11-19(12-31)18-9-16(2)24-21(10-18)29-25-23(17(3)35-24)26(28-15-27-25)30-5-7-34-8-6-30/h4,9-10,15,17,19-20H,1,5-8,11-14H2,2-3H3,(H,27,28,29) DOWVZNDGGHQKKQ-UHFFFAOYSA-N 663774 US20240109912, Compound 103 Cyclin-dependent kinase 7 Homo sapiens 0.320 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663774&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397068 Cc1cc(cc2Nc3ncnc(N4CCS(=N)(=O)CC4)c3COc12)C1CN(C1)C1CCN(CC1)C(=O)C=C InChI=1S/C27H35N7O3S/c1-3-24(35)32-6-4-21(5-7-32)34-14-20(15-34)19-12-18(2)25-23(13-19)31-26-22(16-37-25)27(30-17-29-26)33-8-10-38(28,36)11-9-33/h3,12-13,17,20-21,28H,1,4-11,14-16H2,2H3,(H,29,30,31) OGANZDQRIRPQNK-UHFFFAOYSA-N 663775 US20240109912, Compound 105 Cyclin-dependent kinase 7 Homo sapiens 0.121 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663775&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397069 C=CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2c(c1)C#N InChI=1S/C27H31N7O3/c1-2-24(35)34-14-21(15-34)32-5-3-18(4-6-32)19-11-20(13-28)25-23(12-19)31-26-22(16-37-25)27(30-17-29-26)33-7-9-36-10-8-33/h2,11-12,17-18,21H,1,3-10,14-16H2,(H,29,30,31) FHGWBHQLBDURMN-UHFFFAOYSA-N 663776 US20240109912, Compound 106 Cyclin-dependent kinase 7 Homo sapiens 0.086 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663776&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397070 Cc1cc(cc2Nc3ncnc(N4CC(CO)C4)c3COc12)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C27H34N6O3/c1-3-24(35)32-12-21(13-32)31-6-4-19(5-7-31)20-8-17(2)25-23(9-20)30-26-22(15-36-25)27(29-16-28-26)33-10-18(11-33)14-34/h3,8-9,16,18-19,21,34H,1,4-7,10-15H2,2H3,(H,28,29,30) OJSQKOVINVUDDW-UHFFFAOYSA-N 663777 US20240109912, Compound 107 Cyclin-dependent kinase 7 Homo sapiens 0.960 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663777&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397071 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(-c3cnn(C)c3)c12)C1CN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H29N7O2/c1-5-22(34)33-12-20(13-33)32-10-19(11-32)17-6-15(2)25-21(7-17)30-26-23(16(3)35-25)24(27-14-28-26)18-8-29-31(4)9-18/h5-9,14,16,19-20H,1,10-13H2,2-4H3,(H,27,28,30)/t16-/m1/s1 JOPFLIBPRYGDRW-MRXNPFEDSA-N 663778 US20240109912, Compound 109 Cyclin-dependent kinase 7 Homo sapiens 0.130 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663778&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397072 Cc1cc(cc2Nc3ncnc(C4CCS(=N)(=O)CC4)c3COc12)C1CN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H32N6O3S/c1-3-23(33)32-12-20(13-32)31-10-19(11-31)18-8-16(2)25-22(9-18)30-26-21(14-35-25)24(28-15-29-26)17-4-6-36(27,34)7-5-17/h3,8-9,15,17,19-20,27H,1,4-7,10-14H2,2H3,(H,28,29,30) KBEHQUCESIXJEW-UHFFFAOYSA-N 663779 US20240109912, Compound 110 Cyclin-dependent kinase 7 Homo sapiens 0.032 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663779&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397073 Cc1cc(cc2Nc3ncnc(C4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CN(C1)C(=O)C=C InChI=1S/C26H31N5O4S/c1-3-23(32)31-12-20(13-31)30-10-19(11-30)18-8-16(2)25-22(9-18)29-26-21(14-35-25)24(27-15-28-26)17-4-6-36(33,34)7-5-17/h3,8-9,15,17,19-20H,1,4-7,10-14H2,2H3,(H,27,28,29) JORXVBYILAEYJS-UHFFFAOYSA-N 663780 US20240109912, Compound 111 Cyclin-dependent kinase 7 Homo sapiens 0.112 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663780&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397074 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CN(C1)C1CCN(C1)C(=O)C=C InChI=1S/C26H32N6O4S/c1-3-23(33)31-5-4-20(14-31)32-12-19(13-32)18-10-17(2)24-22(11-18)29-25-21(15-36-24)26(28-16-27-25)30-6-8-37(34,35)9-7-30/h3,10-11,16,19-20H,1,4-9,12-15H2,2H3,(H,27,28,29) WLPODHXWFLIJEV-UHFFFAOYSA-N 663781 US20240109912, Compound 112 Cyclin-dependent kinase 7 Homo sapiens 0.057 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663781&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397075 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-38-26)28(30-18-29-27)33-10-12-39(36,37)13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m1/s1 HJWHCOGDJDVSBC-JOCHJYFZSA-N 663782 US20240109912, Compound 114 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663782&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397076 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-38-26)28(30-18-29-27)33-10-12-39(36,37)13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m1/s1 HJWHCOGDJDVSBC-JOCHJYFZSA-N 663782 US20240109912, Compound 114 Cyclin-dependent kinase 7 Homo sapiens 0.068 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663782&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397077 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-38-26)28(30-18-29-27)33-10-12-39(36,37)13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m0/s1 HJWHCOGDJDVSBC-QFIPXVFZSA-N 663783 US20240109912, Compound 115 Cyclin-dependent kinase 7 Homo sapiens 0.059 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663783&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397078 Cc1cc(cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3COc12)C1CCN(CC1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C28H36N6O4S/c1-3-25(35)34-9-6-22(16-34)32-7-4-20(5-8-32)21-14-19(2)26-24(15-21)31-27-23(17-38-26)28(30-18-29-27)33-10-12-39(36,37)13-11-33/h3,14-15,18,20,22H,1,4-13,16-17H2,2H3,(H,29,30,31)/t22-/m0/s1 HJWHCOGDJDVSBC-QFIPXVFZSA-N 663783 US20240109912, Compound 115 Cyclin-dependent kinase 7 Homo sapiens 0.043 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663783&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397079 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m0/s1 FYQXFTJAWXKYQD-RXVVDRJESA-N 663784 US20240109912, Compound 116 Cyclin-dependent kinase 7 Homo sapiens 0.300 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663784&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397080 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m0/s1 FYQXFTJAWXKYQD-RXVVDRJESA-N 663784 US20240109912, Compound 116 Cyclin-dependent kinase 7 Homo sapiens 0.189 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663784&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397081 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21+/m1/s1 FYQXFTJAWXKYQD-NQIIRXRSSA-N 663785 US20240109912, Compound 117 Cyclin-dependent kinase 7 Homo sapiens 0.034 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663785&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397082 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21+/m1/s1 FYQXFTJAWXKYQD-NQIIRXRSSA-N 663785 US20240109912, Compound 117 Cyclin-dependent kinase 7 Homo sapiens 0.022 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663785&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397083 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21+/m1/s1 FYQXFTJAWXKYQD-NQIIRXRSSA-N 663785 US20240109912, Compound 117 Cyclin-dependent kinase 7 Homo sapiens 0.022 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663785&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397084 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21+/m0/s1 FYQXFTJAWXKYQD-GHTZIAJQSA-N 663786 US20240109912, Compound 118 Cyclin-dependent kinase 7 Homo sapiens 0.280 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663786&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397085 C[C@@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21+/m0/s1 FYQXFTJAWXKYQD-GHTZIAJQSA-N 663786 US20240109912, Compound 118 Cyclin-dependent kinase 7 Homo sapiens 0.281 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663786&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397086 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m1/s1 FYQXFTJAWXKYQD-WIYYLYMNSA-N 663787 US20240109912, Compound 119::US20240109912, Compound 122 Cyclin-dependent kinase 7 Homo sapiens 0.025 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397087 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m1/s1 FYQXFTJAWXKYQD-WIYYLYMNSA-N 663787 US20240109912, Compound 119::US20240109912, Compound 122 Cyclin-dependent kinase 7 Homo sapiens 0.023 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397088 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m1/s1 FYQXFTJAWXKYQD-WIYYLYMNSA-N 663787 US20240109912, Compound 119::US20240109912, Compound 122 Cyclin-dependent kinase 7 Homo sapiens 0.023 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397089 C=CC(=O)N1CCC(CC1)N1CC(C1)c1cc2Nc3ncnc(N4CCOCC4)c3COc2c(c1)C#N InChI=1S/C27H31N7O3/c1-2-24(35)32-5-3-21(4-6-32)34-14-20(15-34)18-11-19(13-28)25-23(12-18)31-26-22(16-37-25)27(30-17-29-26)33-7-9-36-10-8-33/h2,11-12,17,20-21H,1,3-10,14-16H2,(H,29,30,31) DESZRALYTSXQAD-UHFFFAOYSA-N 663788 US20240109912, Compound 120 Cyclin-dependent kinase 7 Homo sapiens 0.295 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663788&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397090 C[C@H]1Oc2c(C)cc(cc2Nc2ncnc(N3CCS(=O)(=O)CC3)c12)C1CN(C1)[C@@H]1CCN(C1)C(=O)C=C InChI=1S/C27H34N6O4S/c1-4-23(34)32-6-5-21(15-32)33-13-20(14-33)19-11-17(2)25-22(12-19)30-26-24(18(3)37-25)27(29-16-28-26)31-7-9-38(35,36)10-8-31/h4,11-12,16,18,20-21H,1,5-10,13-15H2,2-3H3,(H,28,29,30)/t18-,21-/m1/s1 FYQXFTJAWXKYQD-WIYYLYMNSA-N 663787 US20240109912, Compound 119::US20240109912, Compound 122 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663787&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397091 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2OC(C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)33-8-6-23(7-9-33)35-16-22(17-35)21-14-19(2)27-24(15-21)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20,22-23H,6-13,16-17H2,1-3H3,(H,30,31,32) MJYVMMURGMAJSZ-UHFFFAOYSA-N 663790 US20240109912, Compound 123 Cyclin-dependent kinase 7 Homo sapiens 0.193 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663790&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397092 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)33-8-6-23(7-9-33)35-16-22(17-35)21-14-19(2)27-24(15-21)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20,22-23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 MJYVMMURGMAJSZ-HXUWFJFHSA-N 663791 US20240109912, Compound 124 Cyclin-dependent kinase 7 Homo sapiens 0.430 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663791&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397093 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)33-8-6-23(7-9-33)35-16-22(17-35)21-14-19(2)27-24(15-21)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20,22-23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 MJYVMMURGMAJSZ-HXUWFJFHSA-N 663791 US20240109912, Compound 124 Cyclin-dependent kinase 7 Homo sapiens 0.381 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663791&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397094 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)33-8-6-23(7-9-33)35-16-22(17-35)21-14-19(2)27-24(15-21)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20,22-23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m0/s1 MJYVMMURGMAJSZ-FQEVSTJZSA-N 663792 US20240109912, Compound 125 Cyclin-dependent kinase 7 Homo sapiens 0.040 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663792&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397095 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)33-8-6-23(7-9-33)35-16-22(17-35)21-14-19(2)27-24(15-21)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20,22-23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m0/s1 MJYVMMURGMAJSZ-FQEVSTJZSA-N 663792 US20240109912, Compound 125 Cyclin-dependent kinase 7 Homo sapiens 0.020 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663792&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397096 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C27H32N6O4S/c1-3-4-24(34)32-6-5-21(15-32)33-13-20(14-33)19-11-18(2)25-23(12-19)30-26-22(16-37-25)27(29-17-28-26)31-7-9-38(35,36)10-8-31/h11-12,17,20-21H,5-10,13-16H2,1-2H3,(H,28,29,30)/t21-/m0/s1 JWTQMGHIXAMUHW-NRFANRHFSA-N 663793 US20240109912, Compound 126 Cyclin-dependent kinase 7 Homo sapiens 0.108 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663793&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397097 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C27H32N6O4S/c1-3-4-24(34)32-6-5-21(15-32)33-13-20(14-33)19-11-18(2)25-23(12-19)30-26-22(16-37-25)27(29-17-28-26)31-7-9-38(35,36)10-8-31/h11-12,17,20-21H,5-10,13-16H2,1-2H3,(H,28,29,30)/t21-/m1/s1 JWTQMGHIXAMUHW-OAQYLSRUSA-N 663794 US20240109912, Compound 127 Cyclin-dependent kinase 7 Homo sapiens 0.092 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663794&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397098 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.037 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397099 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.003 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397100 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.003 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397101 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.003 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397102 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22-/m0/s1 IRYADJLUIMPLBE-UGKGYDQZSA-N 663796 US20240109912, Compound 129 Cyclin-dependent kinase 7 Homo sapiens 0.577 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663796&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397103 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22-/m0/s1 IRYADJLUIMPLBE-UGKGYDQZSA-N 663796 US20240109912, Compound 129 Cyclin-dependent kinase 7 Homo sapiens 1.11 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663796&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397104 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22-/m1/s1 IRYADJLUIMPLBE-DENIHFKCSA-N 663797 US20240109912, Compound 130 Cyclin-dependent kinase 7 Homo sapiens 0.057 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397105 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22-/m1/s1 IRYADJLUIMPLBE-DENIHFKCSA-N 663797 US20240109912, Compound 130 Cyclin-dependent kinase 7 Homo sapiens 0.117 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397106 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22-/m1/s1 IRYADJLUIMPLBE-DENIHFKCSA-N 663797 US20240109912, Compound 130 Cyclin-dependent kinase 7 Homo sapiens 0.117 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663797&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397107 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m0/s1 IRYADJLUIMPLBE-SIKLNZKXSA-N 663798 US20240109912, Compound 131 Cyclin-dependent kinase 7 Homo sapiens 1.08 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663798&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397108 CC#CC(=O)N1CC[C@H](C1)N1CC(C1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m0/s1 IRYADJLUIMPLBE-SIKLNZKXSA-N 663798 US20240109912, Compound 131 Cyclin-dependent kinase 7 Homo sapiens 2.05 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663798&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397109 CC#CC(=O)N1CCC(CC1)N1CC(C1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-3-4-25(35)32-7-5-22(6-8-32)34-15-21(16-34)20-13-19(2)26-24(14-20)31-27-23(17-38-26)28(30-18-29-27)33-9-11-39(36,37)12-10-33/h13-14,18,21-22H,5-12,15-17H2,1-2H3,(H,29,30,31) DMAJGBUBUAMDBP-UHFFFAOYSA-N 663799 US20240109912, Compound 133 Cyclin-dependent kinase 7 Homo sapiens 0.173 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663799&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397110 CC#CC(=O)N1CC[C@@H](C1)N1CCC(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-3-4-26(36)35-10-7-23(17-35)33-8-5-21(6-9-33)22-15-20(2)27-25(16-22)32-28-24(18-39-27)29(31-19-30-28)34-11-13-40(37,38)14-12-34/h15-16,19,21,23H,5-14,17-18H2,1-2H3,(H,30,31,32)/t23-/m0/s1 YFIHLTXNSKMFPO-QHCPKHFHSA-N 663800 US20240109912, Compound 134 Cyclin-dependent kinase 7 Homo sapiens 0.059 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663800&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397111 CC#CC(=O)N1CC[C@H](C1)N1CCC(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-3-4-26(36)35-10-7-23(17-35)33-8-5-21(6-9-33)22-15-20(2)27-25(16-22)32-28-24(18-39-27)29(31-19-30-28)34-11-13-40(37,38)14-12-34/h15-16,19,21,23H,5-14,17-18H2,1-2H3,(H,30,31,32)/t23-/m1/s1 YFIHLTXNSKMFPO-HSZRJFAPSA-N 663801 US20240109912, Compound 135 Cyclin-dependent kinase 7 Homo sapiens 0.034 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663801&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397112 CC#CC(=O)N1CCC(CC1)N1CCN(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H37N7O4S/c1-3-4-26(37)35-7-5-22(6-8-35)33-9-11-34(12-10-33)23-17-21(2)27-25(18-23)32-28-24(19-40-27)29(31-20-30-28)36-13-15-41(38,39)16-14-36/h17-18,20,22H,5-16,19H2,1-2H3,(H,30,31,32) VUHVHSMZUQZHDT-UHFFFAOYSA-N 663802 US20240109912, Compound 136 Cyclin-dependent kinase 7 Homo sapiens 0.087 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663802&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397113 CC#CC(=O)N1CCN(CC1)C1CCN(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H37N7O4S/c1-3-4-26(37)35-11-9-34(10-12-35)22-5-7-33(8-6-22)23-17-21(2)27-25(18-23)32-28-24(19-40-27)29(31-20-30-28)36-13-15-41(38,39)16-14-36/h17-18,20,22H,5-16,19H2,1-2H3,(H,30,31,32) GJDTZFJYQPMTAX-UHFFFAOYSA-N 663803 US20240109912, Compound 137 Cyclin-dependent kinase 7 Homo sapiens 0.254 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663803&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397114 CC#CC(=O)N1CCC(CC1)N1CCC(=CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C30H36N6O4S/c1-3-4-27(37)35-11-7-24(8-12-35)34-9-5-22(6-10-34)23-17-21(2)28-26(18-23)33-29-25(19-40-28)30(32-20-31-29)36-13-15-41(38,39)16-14-36/h5,17-18,20,24H,6-16,19H2,1-2H3,(H,31,32,33) SEYDEPIULDYDHC-UHFFFAOYSA-N 663804 US20240109912, Compound 138 Cyclin-dependent kinase 7 Homo sapiens 0.091 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663804&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397115 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3[C@@H](C)Oc2c(C)n1 InChI=1S/C28H35N7O4S/c1-4-5-24(36)35-15-21(16-35)33-8-6-20(7-9-33)22-14-23-26(18(2)31-22)39-19(3)25-27(32-23)29-17-30-28(25)34-10-12-40(37,38)13-11-34/h14,17,19-21H,6-13,15-16H2,1-3H3,(H,29,30,32)/t19-/m1/s1 WXMOXAQMFWVLEI-LJQANCHMSA-N 663805 US20240109912, Compound 139 Cyclin-dependent kinase 7 Homo sapiens 0.135 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663805&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397116 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3[C@@H](C)Oc2c(C)n1 InChI=1S/C28H35N7O4S/c1-4-5-24(36)35-15-21(16-35)33-8-6-20(7-9-33)22-14-23-26(18(2)31-22)39-19(3)25-27(32-23)29-17-30-28(25)34-10-12-40(37,38)13-11-34/h14,17,19-21H,6-13,15-16H2,1-3H3,(H,29,30,32)/t19-/m1/s1 WXMOXAQMFWVLEI-LJQANCHMSA-N 663805 US20240109912, Compound 139 Cyclin-dependent kinase 7 Homo sapiens 0.047 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663805&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397117 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3[C@H](C)Oc2c(C)n1 InChI=1S/C28H35N7O4S/c1-4-5-24(36)35-15-21(16-35)33-8-6-20(7-9-33)22-14-23-26(18(2)31-22)39-19(3)25-27(32-23)29-17-30-28(25)34-10-12-40(37,38)13-11-34/h14,17,19-21H,6-13,15-16H2,1-3H3,(H,29,30,32)/t19-/m0/s1 WXMOXAQMFWVLEI-IBGZPJMESA-N 663806 US20240109912, Compound 140 Cyclin-dependent kinase 7 Homo sapiens 2.57 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663806&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397118 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.008 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397119 CC#CC(=O)N1CC(C)(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C30H38N6O4S/c1-5-6-25(37)35-17-30(4,18-35)36-9-7-22(8-10-36)23-15-20(2)27-24(16-23)33-28-26(21(3)40-27)29(32-19-31-28)34-11-13-41(38,39)14-12-34/h15-16,19,21-22H,7-14,17-18H2,1-4H3,(H,31,32,33)/t21-/m1/s1 ZWVVRVAIEHEVSU-OAQYLSRUSA-N 663808 US20240109912, Compound 144 Cyclin-dependent kinase 7 Homo sapiens 0.004 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663808&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397120 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 OLEFHQBTXFCZON-HXUWFJFHSA-N 663809 US20240109912, Compound 148::US20240109912, Compound 160 Cyclin-dependent kinase 7 Homo sapiens 0.022 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663809&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397121 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 OLEFHQBTXFCZON-HXUWFJFHSA-N 663809 US20240109912, Compound 148::US20240109912, Compound 160 Cyclin-dependent kinase 7 Homo sapiens 0.006 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663809&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397122 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 OLEFHQBTXFCZON-HXUWFJFHSA-N 663809 US20240109912, Compound 148::US20240109912, Compound 160 Cyclin-dependent kinase 7 Homo sapiens 0.006 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663809&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397123 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 OLEFHQBTXFCZON-HXUWFJFHSA-N 663809 US20240109912, Compound 148::US20240109912, Compound 160 Cyclin-dependent kinase 7 Homo sapiens 0.006 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663809&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397124 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m0/s1 OLEFHQBTXFCZON-FQEVSTJZSA-N 663810 US20240109912, Compound 150 Cyclin-dependent kinase 7 Homo sapiens 0.283 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663810&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397125 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m0/s1 OLEFHQBTXFCZON-FQEVSTJZSA-N 663810 US20240109912, Compound 150 Cyclin-dependent kinase 7 Homo sapiens 0.180 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663810&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397126 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-3-4-25(35)34-15-22(16-34)32-7-5-20(6-8-32)21-13-19(2)26-24(14-21)31-27-23(17-38-26)28(30-18-29-27)33-9-11-39(36,37)12-10-33/h13-14,18,20,22H,5-12,15-17H2,1-2H3,(H,29,30,31) XPSBWRWTPUDXHU-UHFFFAOYSA-N 663811 US20240109912, Compound 151 Cyclin-dependent kinase 7 Homo sapiens 0.160 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663811&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397127 CC#CC(=O)N1CCC(C1)N1CCC(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-3-4-26(36)35-10-7-23(17-35)33-8-5-21(6-9-33)22-15-20(2)27-25(16-22)32-28-24(18-39-27)29(31-19-30-28)34-11-13-40(37,38)14-12-34/h15-16,19,21,23H,5-14,17-18H2,1-2H3,(H,30,31,32) YFIHLTXNSKMFPO-UHFFFAOYSA-N 663812 US20240109912, Compound 152 Cyclin-dependent kinase 7 Homo sapiens 0.029 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663812&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397128 CC#CC(=O)N1CCC(CC1)N1CCN(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C30H39N7O4S/c1-4-5-26(38)36-8-6-23(7-9-36)34-10-12-35(13-11-34)24-18-21(2)28-25(19-24)33-29-27(22(3)41-28)30(32-20-31-29)37-14-16-42(39,40)17-15-37/h18-20,22-23H,6-17H2,1-3H3,(H,31,32,33)/t22-/m1/s1 IUJCYFAIPIODPA-JOCHJYFZSA-N 663813 US20240109912, Compound 154 Cyclin-dependent kinase 7 Homo sapiens 0.004 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663813&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397129 CC#CC(=O)N1CC(C1)N1CCN(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H35N7O4S/c1-4-5-24(36)35-16-22(17-35)33-8-6-32(7-9-33)21-14-19(2)26-23(15-21)31-27-25(20(3)39-26)28(30-18-29-27)34-10-12-40(37,38)13-11-34/h14-15,18,20,22H,6-13,16-17H2,1-3H3,(H,29,30,31)/t20-/m1/s1 QPMSZTCDIYOWLB-HXUWFJFHSA-N 663814 US20240109912, Compound 155 Cyclin-dependent kinase 7 Homo sapiens 0.002 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663814&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397130 CC#CC(=O)N1CC[C@@H](C1)N1CC(C1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C28H34N6O4S/c1-4-5-24(35)33-7-6-22(16-33)34-14-21(15-34)20-12-18(2)26-23(13-20)31-27-25(19(3)38-26)28(30-17-29-27)32-8-10-39(36,37)11-9-32/h12-13,17,19,21-22H,6-11,14-16H2,1-3H3,(H,29,30,31)/t19-,22+/m1/s1 IRYADJLUIMPLBE-KNQAVFIVSA-N 663795 US20240109912, Compound 128::US20240109912, Compound 142::US20240109912, Compound 159 Cyclin-dependent kinase 7 Homo sapiens 0.009 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663795&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397131 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2O[C@H](C)c3c(Nc2c1)ncnc3N1CCS(=O)(=O)CC1 InChI=1S/C29H36N6O4S/c1-4-5-25(36)35-16-23(17-35)33-8-6-21(7-9-33)22-14-19(2)27-24(15-22)32-28-26(20(3)39-27)29(31-18-30-28)34-10-12-40(37,38)13-11-34/h14-15,18,20-21,23H,6-13,16-17H2,1-3H3,(H,30,31,32)/t20-/m1/s1 OLEFHQBTXFCZON-HXUWFJFHSA-N 663809 US20240109912, Compound 148::US20240109912, Compound 160 Cyclin-dependent kinase 7 Homo sapiens 0.013 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663809&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397132 C[C@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C#C)C1CCN(CC1)C1CN(C1)C(=O)C=C InChI=1S/C29H34N6O4S/c1-4-20-14-22(21-6-8-33(9-7-21)23-16-35(17-23)25(36)5-2)15-24-27(20)39-19(3)26-28(32-24)30-18-31-29(26)34-10-12-40(37,38)13-11-34/h1,5,14-15,18-19,21,23H,2,6-13,16-17H2,3H3,(H,30,31,32)/t19-/m1/s1 IDBKKKSMJPUXCZ-LJQANCHMSA-N 663817 US20240109912, Compound 189 Cyclin-dependent kinase 7 Homo sapiens 0.081 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663817&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397133 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3[C@H](C)Oc2c(c1)C#C InChI=1S/C30H34N6O4S/c1-4-6-26(37)36-17-24(18-36)34-9-7-22(8-10-34)23-15-21(5-2)28-25(16-23)33-29-27(20(3)40-28)30(32-19-31-29)35-11-13-41(38,39)14-12-35/h2,15-16,19-20,22,24H,7-14,17-18H2,1,3H3,(H,31,32,33)/t20-/m0/s1 LETXDJVHWSUGLX-FQEVSTJZSA-N 663818 US20240109912, Compound 191 Cyclin-dependent kinase 7 Homo sapiens 0.100 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663818&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397134 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc2Nc3ncnc(N4CCS(=O)(=O)CC4)c3[C@@H](C)Oc2c(c1)C#C InChI=1S/C30H34N6O4S/c1-4-6-26(37)36-17-24(18-36)34-9-7-22(8-10-34)23-15-21(5-2)28-25(16-23)33-29-27(20(3)40-28)30(32-19-31-29)35-11-13-41(38,39)14-12-35/h2,15-16,19-20,22,24H,7-14,17-18H2,1,3H3,(H,31,32,33)/t20-/m1/s1 LETXDJVHWSUGLX-HXUWFJFHSA-N 663819 US20240109912, Compound 192 Cyclin-dependent kinase 7 Homo sapiens 0.856 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663819&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397135 C[C@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C#C)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C28H32N6O4S/c1-4-19-12-20(21-14-34(15-21)22-6-7-33(16-22)24(35)5-2)13-23-26(19)38-18(3)25-27(31-23)29-17-30-28(25)32-8-10-39(36,37)11-9-32/h1,5,12-13,17-18,21-22H,2,6-11,14-16H2,3H3,(H,29,30,31)/t18-,22+/m1/s1 PHKGZAWZPYLIFM-GCJKJVERSA-N 663820 US20240109912, Compound 193 Cyclin-dependent kinase 7 Homo sapiens 0.156 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663820&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397136 C[C@@H]1Oc2c(Nc3ncnc(N4CCS(=O)(=O)CC4)c13)cc(cc2C#C)C1CN(C1)[C@H]1CCN(C1)C(=O)C=C InChI=1S/C28H32N6O4S/c1-4-19-12-20(21-14-34(15-21)22-6-7-33(16-22)24(35)5-2)13-23-26(19)38-18(3)25-27(31-23)29-17-30-28(25)32-8-10-39(36,37)11-9-32/h1,5,12-13,17-18,21-22H,2,6-11,14-16H2,3H3,(H,29,30,31)/t18-,22-/m0/s1 PHKGZAWZPYLIFM-AVRDEDQJSA-N 663821 US20240109912, Compound 194 Cyclin-dependent kinase 7 Homo sapiens 0.018 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663821&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1397137 CC#CC(=O)N1CC(C1)N1CCC(CC1)c1cc(C)c2OCc3c(Nc2c1)ncnc3N1CCOC2(COC2)C1 InChI=1S/C30H36N6O4/c1-3-4-26(37)36-13-23(14-36)34-7-5-21(6-8-34)22-11-20(2)27-25(12-22)33-28-24(15-39-27)29(32-19-31-28)35-9-10-40-30(16-35)17-38-18-30/h11-12,19,21,23H,5-10,13-18H2,1-2H3,(H,31,32,33) VYHKMLGSUBVDCN-UHFFFAOYSA-N 663822 US20240109912, Compound 195 Cyclin-dependent kinase 7 Homo sapiens 0.108 US Patent 10.7270/Q2BP073V US20240109912 STANSFIELD, I; LIGNY, YA; SIMONNET, YR; AMBLARD, NC Janssen Pharmaceutica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=663822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=663822&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51547447 C[C@H](CO)Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Br InChI=1S/C13H16BrN5O3S/c1-8(7-20)17-12-11(14)6-16-13(19-12)18-9-2-4-10(5-3-9)23(15,21)22/h2-6,8,20H,7H2,1H3,(H2,15,21,22)(H2,16,17,18,19)/t8-/m1/s1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 50553480 CHEMBL4741442 Cyclin-dependent kinase 7 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.3c00566 10.7270/Q2FX7FV6 37234044 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553480&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3I6 4BGH 58890996 461692248 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51570494 COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1NC(=O)CCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O InChI=1S/C28H37N5O8/c1-38-21-10-9-17(7-8-18-15-22(39-2)26(41-4)23(16-18)40-3)14-20(21)33-25(35)12-11-24(34)32-19(27(36)37)6-5-13-31-28(29)30/h7-10,14-16,19H,5-6,11-13H2,1-4H3,(H,32,34)(H,33,35)(H,36,37)(H4,29,30,31)/b8-7-/t19-/m0/s1 BNWIVWQCCFRSQN-FQQSSWHASA-N 50631617 CHEMBL5440517 Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c01572 10.7270/Q2XS60VD 38093696 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631617&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51547444 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.1021/acs.jmedchem.3c00566 10.7270/Q2FX7FV6 37234044 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,8BU9,1YGK,2A4L,1UNL,8FP0 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51547445 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-dependent kinase 7 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.3c00566 10.7270/Q2FX7FV6 37234044 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51547446 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-dependent kinase 7 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c00566 10.7270/Q2FX7FV6 37234044 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51554946 CN(C)C\C=C\C(O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H30ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,28,33,35,40H,16H2,1-2H3,(H,36,41)(H,34,37,38)/b11-6+ GGKAQFSAJDFYOL-IZZDOVSWSA-N 50625574 CHEMBL5440767 Cyclin-dependent kinase 7 Homo sapiens 238 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625574&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51554947 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1 RUBYHLPRZRMTJO-MOVYNIQHSA-N 50528813 CHEMBL4163879 Cyclin-dependent kinase 7 Homo sapiens 8500 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528813&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025540 440737395 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51554958 CCc1cnn2c(NCc3nc4ccc(F)c(F)c4[nH]3)cc(nc12)N1CCCC[C@H]1CCO InChI=1S/C23H27F2N7O/c1-2-14-12-27-32-19(26-13-18-28-17-7-6-16(24)21(25)22(17)29-18)11-20(30-23(14)32)31-9-4-3-5-15(31)8-10-33/h6-7,11-12,15,26,33H,2-5,8-10,13H2,1H3,(H,28,29)/t15-/m0/s1 UQKMSJFNACXHSL-HNNXBMFYSA-N 50625575 CHEMBL5414905 Cyclin-dependent kinase 7 Homo sapiens 21200 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625575&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51554959 CCn1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO InChI=1S/C22H26F2N8O/c1-2-31-12-26-19-20(25-11-16-27-15-7-6-14(23)17(24)18(15)28-16)29-22(30-21(19)31)32-9-4-3-5-13(32)8-10-33/h6-7,12-13,33H,2-5,8-11H2,1H3,(H,27,28)(H,25,29,30)/t13-/m0/s1 HVFVQLFPRQYJTR-ZDUSSCGKSA-N 50540077 CHEMBL4649135 Cyclin-dependent kinase 7 Homo sapiens >30000 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540077&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 131953498 442141640 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51554960 CC(C)n1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO InChI=1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1 KULPPFCRBINTBS-AWEZNQCLSA-N 50590456 CHEMBL5188909 Cyclin-dependent kinase 7 Homo sapiens >30000 ChEMBL 10.1039/d3md00004d 10.7270/Q25D8X7N 37731700 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50590456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=995&target=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50590456&enzyme=Cyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134691746 482601308 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8S0T,8S0R,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19