BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 403377 CCCCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C24H22Cl2N2O2/c1-3-4-12-24(29,20-13-15(2)28-30-20)17-10-11-19-18(14-17)22(25)21(23(26)27-19)16-8-6-5-7-9-16/h5-11,13-14,29H,3-4,12H2,1-2H3 TZDNTEMAZXWJSW-UHFFFAOYSA-N 231221 US9346782, 1 Nuclear receptor ROR-gamma [258-518,Y502F] 150 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231221&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118012543 336950493 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403378 CCC(O)(c1cc(C)no1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C22H18Cl2N2O2/c1-3-22(27,18-11-13(2)26-28-18)15-9-10-17-16(12-15)20(23)19(21(24)25-17)14-7-5-4-6-8-14/h4-12,27H,3H2,1-2H3 OJDAGVRVDHLHFS-UHFFFAOYSA-N 231222 US9346782, 2 Nuclear receptor ROR-gamma [258-518,Y502F] 450 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231222&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118012546 336950494 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403379 Cn1cncc1C(O)(C1CC1)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C23H19Cl2N3O/c1-28-13-26-12-19(28)23(29,15-7-8-15)16-9-10-18-17(11-16)21(24)20(22(25)27-18)14-5-3-2-4-6-14/h2-6,9-13,15,29H,7-8H2,1H3 PEXKKGMYAIJRBR-UHFFFAOYSA-N 231223 US9346782, 3 Nuclear receptor ROR-gamma [258-518,Y502F] >6000 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231223&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006470 336950495 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403380 CCCCC(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C24H23Cl2N3O/c1-3-4-12-24(30,20-14-27-15-29(20)2)17-10-11-19-18(13-17)22(25)21(23(26)28-19)16-8-6-5-7-9-16/h5-11,13-15,30H,3-4,12H2,1-2H3 GAMJCHAOPZZQJQ-UHFFFAOYSA-N 231224 US9346782, 4 Nuclear receptor ROR-gamma [258-518,Y502F] 1500 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231224&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118012542 336950496 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403381 CC(C)C(O)(c1cncn1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C23H21Cl2N3O/c1-14(2)23(29,19-12-26-13-28(19)3)16-9-10-18-17(11-16)21(24)20(22(25)27-18)15-7-5-4-6-8-15/h4-14,29H,1-3H3 ISUSSPVKTRKAHO-UHFFFAOYSA-N 231225 US9346782, 5 Nuclear receptor ROR-gamma [258-518,Y502F] 1300 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231225&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 91669192 336950497 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403382 CCC(O)(c1cncn1C)c1ccc2nc(OC)c(Cc3ccc(cc3)S(C)(=O)=O)c(Cl)c2c1 InChI=1S/C25H26ClN3O4S/c1-5-25(30,22-14-27-15-29(22)2)17-8-11-21-19(13-17)23(26)20(24(28-21)33-3)12-16-6-9-18(10-7-16)34(4,31)32/h6-11,13-15,30H,5,12H2,1-4H3 VLVWBDVHEFIMMA-UHFFFAOYSA-N 231226 US9346782, 6 Nuclear receptor ROR-gamma [258-518,Y502F] 1700 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231226&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006999 336950498 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403383 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3 HWLRVNIRYWWAOZ-UHFFFAOYSA-N 231227 US9346782, 7a::US9346782, 7b::US9346782, 7c Nuclear receptor ROR-gamma [258-518,Y502F] 230 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231227&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006229 336950499 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403384 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3 HWLRVNIRYWWAOZ-UHFFFAOYSA-N 231227 US9346782, 7a::US9346782, 7b::US9346782, 7c Nuclear receptor ROR-gamma [258-518,Y502F] 360 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231227&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006229 336950499 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403385 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(C)=O InChI=1S/C26H22ClF3N2O3/c1-4-25(34,19-13-32(14-19)15(2)33)18-9-10-22-20(12-18)23(27)21(24(31-22)35-3)11-16-5-7-17(8-6-16)26(28,29)30/h1,5-10,12,19,34H,11,13-14H2,2-3H3 HWLRVNIRYWWAOZ-UHFFFAOYSA-N 231227 US9346782, 7a::US9346782, 7b::US9346782, 7c Nuclear receptor ROR-gamma [258-518,Y502F] 98 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231227&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006229 336950499 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403386 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)C1CN(C1)C(=O)OC(C)(C)C InChI=1S/C29H28ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h1,7-12,14,20,37H,13,15-16H2,2-5H3 KGQNXXWLTAQQPJ-UHFFFAOYSA-N 231228 US9346782, 8 Nuclear receptor ROR-gamma [258-518,Y502F] 4000 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006295 336950500 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403387 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3 STKMELJJEGZLIB-UHFFFAOYSA-N 231229 US9346782, 9a::US9346782, 9b::US9346782, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 280 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006589 336950501 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403388 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3 STKMELJJEGZLIB-UHFFFAOYSA-N 231229 US9346782, 9a::US9346782, 9b::US9346782, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 1300 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006589 336950501 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403389 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cncn1C InChI=1S/C24H21ClF3N3O2/c1-23(32,20-12-29-13-31(20)2)16-8-9-19-17(11-16)21(25)18(22(30-19)33-3)10-14-4-6-15(7-5-14)24(26,27)28/h4-9,11-13,32H,10H2,1-3H3 STKMELJJEGZLIB-UHFFFAOYSA-N 231229 US9346782, 9a::US9346782, 9b::US9346782, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 180 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006589 336950501 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403390 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3 GZHHSXYGQHWIGF-UHFFFAOYSA-N 231230 US9346782, 10a::US9346782, 10b::US9346782, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 250 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006197 336950502 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403391 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3 GZHHSXYGQHWIGF-UHFFFAOYSA-N 231230 US9346782, 10a::US9346782, 10b::US9346782, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 260 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006197 336950502 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403392 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1oc(C)nc1C InChI=1S/C25H22ClF3N2O3/c1-13-22(34-14(2)30-13)24(3,32)17-9-10-20-18(12-17)21(26)19(23(31-20)33-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12,32H,11H2,1-4H3 GZHHSXYGQHWIGF-UHFFFAOYSA-N 231230 US9346782, 10a::US9346782, 10b::US9346782, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 330 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006197 336950502 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403393 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3 KCEVZBCVYHCXBO-UHFFFAOYSA-N 231231 US9346782, 11a::US9346782, 11b::US9346782, 11c Nuclear receptor ROR-gamma [258-518,Y502F] 110 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006575 336950503 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403394 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3 KCEVZBCVYHCXBO-UHFFFAOYSA-N 231231 US9346782, 11a::US9346782, 11b::US9346782, 11c Nuclear receptor ROR-gamma [258-518,Y502F] 210 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006575 336950503 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403395 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnnn1C InChI=1S/C23H20ClF3N4O2/c1-22(32,19-12-28-30-31(19)2)15-8-9-18-16(11-15)20(24)17(21(29-18)33-3)10-13-4-6-14(7-5-13)23(25,26)27/h4-9,11-12,32H,10H2,1-3H3 KCEVZBCVYHCXBO-UHFFFAOYSA-N 231231 US9346782, 11a::US9346782, 11b::US9346782, 11c Nuclear receptor ROR-gamma [258-518,Y502F] 15 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006575 336950503 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403396 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3 ZSGWUOZOUGDWCX-UHFFFAOYSA-N 231232 US9346782, 12a::US9346782, 12b::US9346782, 12c Nuclear receptor ROR-gamma [258-518,Y502F] 370 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006258 336950504 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403397 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3 ZSGWUOZOUGDWCX-UHFFFAOYSA-N 231232 US9346782, 12a::US9346782, 12b::US9346782, 12c Nuclear receptor ROR-gamma [258-518,Y502F] 500 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006258 336950504 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403398 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1cnc(C)n1C InChI=1S/C25H23ClF3N3O2/c1-14-30-13-21(32(14)3)24(2,33)17-9-10-20-18(12-17)22(26)19(23(31-20)34-4)11-15-5-7-16(8-6-15)25(27,28)29/h5-10,12-13,33H,11H2,1-4H3 ZSGWUOZOUGDWCX-UHFFFAOYSA-N 231232 US9346782, 12a::US9346782, 12b::US9346782, 12c Nuclear receptor ROR-gamma [258-518,Y502F] 41 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006258 336950504 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403399 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3 IQQZPOGNFNKHHN-UHFFFAOYSA-N 231233 US9346782, 13a::US9346782, 13b::US9346782, 13c Nuclear receptor ROR-gamma [258-518,Y502F] 52 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231233&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006261 336950505 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403400 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3 IQQZPOGNFNKHHN-UHFFFAOYSA-N 231233 US9346782, 13a::US9346782, 13b::US9346782, 13c Nuclear receptor ROR-gamma [258-518,Y502F] 200 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231233&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006261 336950505 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403401 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(C)(O)c1ccc(C)nc1C InChI=1S/C27H24ClF3N2O2/c1-15-5-11-22(16(2)32-15)26(3,34)19-10-12-23-20(14-19)24(28)21(25(33-23)35-4)13-17-6-8-18(9-7-17)27(29,30)31/h5-12,14,34H,13H2,1-4H3 IQQZPOGNFNKHHN-UHFFFAOYSA-N 231233 US9346782, 13a::US9346782, 13b::US9346782, 13c Nuclear receptor ROR-gamma [258-518,Y502F] 46 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231233&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006261 336950505 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403402 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3 ACZQKZSCRWXAGR-UHFFFAOYSA-N 231234 US9346782, 14a::US9346782, 14b::US9346782, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 210 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231234&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006481 336950506 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403403 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3 ACZQKZSCRWXAGR-UHFFFAOYSA-N 231234 US9346782, 14a::US9346782, 14b::US9346782, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 66 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231234&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006481 336950506 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403404 COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)C(F)(F)F)C(O)(C#C)c1cnc(C)n1C InChI=1S/C26H21ClF3N3O2/c1-5-25(34,22-14-31-15(2)33(22)3)18-10-11-21-19(13-18)23(27)20(24(32-21)35-4)12-16-6-8-17(9-7-16)26(28,29)30/h1,6-11,13-14,34H,12H2,2-4H3 ACZQKZSCRWXAGR-UHFFFAOYSA-N 231234 US9346782, 14a::US9346782, 14b::US9346782, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 310 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231234&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006481 336950506 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403405 CC(C)C(O)(c1sc(C)nc1C)c1ccc2nc(Cl)c(-c3ccccc3)c(Cl)c2c1 InChI=1S/C24H22Cl2N2OS/c1-13(2)24(29,22-14(3)27-15(4)30-22)17-10-11-19-18(12-17)21(25)20(23(26)28-19)16-8-6-5-7-9-16/h5-13,29H,1-4H3 GBZIGVNOEFBTMY-UHFFFAOYSA-N 231235 US9346782, 15 Nuclear receptor ROR-gamma [258-518,Y502F] 500 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006578 336950507 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 403406 CCC(O)(C1CN(C1)C(=O)OC(C)(C)C)c1ccc2nc(OC)c(Cc3ccc(cc3)C(F)(F)F)c(Cl)c2c1 InChI=1S/C29H32ClF3N2O4/c1-6-28(37,20-15-35(16-20)26(36)39-27(2,3)4)19-11-12-23-21(14-19)24(30)22(25(34-23)38-5)13-17-7-9-18(10-8-17)29(31,32)33/h7-12,14,20,37H,6,13,15-16H2,1-5H3 LZSHHVICPQULEG-UHFFFAOYSA-N 231237 US9346782, 17 Nuclear receptor ROR-gamma [258-518,Y502F] 500 US Patent 10.7270/Q2DB80PS aid1802870 US9346782 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Cummings, MD Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=231237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9890&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=231237&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 118006465 336950508 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8