BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 963636 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccccc2)=C1O InChI=1S/C30H44O4/c1-20(2)12-14-24-27(32)26(25(31)15-13-23-10-8-7-9-11-23)29(34)30(28(24)33,18-16-21(3)4)19-17-22(5)6/h7-11,20-22,32-33H,12-19H2,1-6H3 ZDBYSQKESQYZEM-UHFFFAOYSA-N 466507 US10800725, Compound 15 DNA-directed RNA polymerase subunit alpha 11000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466507&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 56933291 441576213 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963639 CCC1=C(O)C(CC)(CC)C(=O)C(C(=O)CCc2ccccc2)=C1O InChI=1S/C21H26O4/c1-4-15-18(23)17(20(25)21(5-2,6-3)19(15)24)16(22)13-12-14-10-8-7-9-11-14/h7-11,23-24H,4-6,12-13H2,1-3H3 UICDYZNJGOHHIJ-UHFFFAOYSA-N 466508 US10800725, Compound 16 DNA-directed RNA polymerase subunit alpha >400000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466508&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66695524 441576214 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963642 CCCC1=C(O)C(CCC)(CCC)C(=O)C(C(=O)CCc2ccccc2)=C1O InChI=1S/C24H32O4/c1-4-10-18-21(26)20(19(25)14-13-17-11-8-7-9-12-17)23(28)24(15-5-2,16-6-3)22(18)27/h7-9,11-12,26-27H,4-6,10,13-16H2,1-3H3 VTKCMGOCYPFGKI-UHFFFAOYSA-N 466509 US10800725, Compound 17 DNA-directed RNA polymerase subunit alpha >400000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466509&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66690756 441576215 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963645 CCCCC1=C(O)C(CCCC)(CCCC)C(=O)C(C(=O)CCc2ccccc2)=C1O InChI=1S/C27H38O4/c1-4-7-15-21-24(29)23(22(28)17-16-20-13-11-10-12-14-20)26(31)27(25(21)30,18-8-5-2)19-9-6-3/h10-14,29-30H,4-9,15-19H2,1-3H3 WXGLNSMONCMJPI-UHFFFAOYSA-N 466510 US10800725, Compound 18 DNA-directed RNA polymerase subunit alpha 80000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466510&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691670 441576216 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963648 CCCCCC1=C(O)C(CCCCC)(CCCCC)C(=O)C(C(=O)CCc2ccccc2)=C1O InChI=1S/C30H44O4/c1-4-7-11-18-24-27(32)26(25(31)20-19-23-16-12-10-13-17-23)29(34)30(28(24)33,21-14-8-5-2)22-15-9-6-3/h10,12-13,16-17,32-33H,4-9,11,14-15,18-22H2,1-3H3 CDHIVEPLYUFPHA-UHFFFAOYSA-N 466511 US10800725, Compound 19 DNA-directed RNA polymerase subunit alpha 13000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466511&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691109 441576217 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963651 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)C(C)Cc2ccccc2)=C1O InChI=1S/C31H46O4/c1-20(2)13-14-25-28(33)26(27(32)23(7)19-24-11-9-8-10-12-24)30(35)31(29(25)34,17-15-21(3)4)18-16-22(5)6/h8-12,20-23,33-34H,13-19H2,1-7H3 LOIWTQXXCIHJAY-UHFFFAOYSA-N 466512 US10800725, Compound 20 DNA-directed RNA polymerase subunit alpha 13000 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466512&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691082 441576218 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963654 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccccc2Cl)=C1O InChI=1S/C30H43ClO4/c1-19(2)11-13-23-27(33)26(25(32)14-12-22-9-7-8-10-24(22)31)29(35)30(28(23)34,17-15-20(3)4)18-16-21(5)6/h7-10,19-21,33-34H,11-18H2,1-6H3 JTEYEXQIIFCNHK-UHFFFAOYSA-N 466513 US10800725, Compound 1 DNA-directed RNA polymerase subunit alpha 5700 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466513&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66693620 441576219 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963657 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2cccc(Cl)c2)=C1O InChI=1S/C30H43ClO4/c1-19(2)10-12-24-27(33)26(25(32)13-11-22-8-7-9-23(31)18-22)29(35)30(28(24)34,16-14-20(3)4)17-15-21(5)6/h7-9,18-21,33-34H,10-17H2,1-6H3 BPLCKKDUWDYPPJ-UHFFFAOYSA-N 466514 US10800725, Compound 2 DNA-directed RNA polymerase subunit alpha 5900 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466514&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691111 441576220 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963660 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccc(Cl)cc2)=C1O InChI=1S/C30H43ClO4/c1-19(2)7-13-24-27(33)26(25(32)14-10-22-8-11-23(31)12-9-22)29(35)30(28(24)34,17-15-20(3)4)18-16-21(5)6/h8-9,11-12,19-21,33-34H,7,10,13-18H2,1-6H3 ZZEQBVNYSRNWFQ-UHFFFAOYSA-N 466515 US10800725, Compound 3 DNA-directed RNA polymerase subunit alpha 2400 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466515&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691745 441576221 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963663 COc1ccccc1CCC(=O)C1=C(O)C(CCC(C)C)=C(O)C(CCC(C)C)(CCC(C)C)C1=O InChI=1S/C31H46O5/c1-20(2)12-14-24-28(33)27(25(32)15-13-23-10-8-9-11-26(23)36-7)30(35)31(29(24)34,18-16-21(3)4)19-17-22(5)6/h8-11,20-22,33-34H,12-19H2,1-7H3 UCJKFQMBZVUAAK-UHFFFAOYSA-N 466516 US10800725, Compound 4 DNA-directed RNA polymerase subunit alpha 4300 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466516&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691881 441576222 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963666 COc1cccc(CCC(=O)C2=C(O)C(CCC(C)C)=C(O)C(CCC(C)C)(CCC(C)C)C2=O)c1 InChI=1S/C31H46O5/c1-20(2)11-13-25-28(33)27(26(32)14-12-23-9-8-10-24(19-23)36-7)30(35)31(29(25)34,17-15-21(3)4)18-16-22(5)6/h8-10,19-22,33-34H,11-18H2,1-7H3 LOMFWUGGVZISIX-UHFFFAOYSA-N 466517 US10800725, Compound 5 DNA-directed RNA polymerase subunit alpha 3100 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466517&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691114 441576223 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963669 COc1ccc(CCC(=O)C2=C(O)C(CCC(C)C)=C(O)C(CCC(C)C)(CCC(C)C)C2=O)cc1 InChI=1S/C31H46O5/c1-20(2)8-14-25-28(33)27(26(32)15-11-23-9-12-24(36-7)13-10-23)30(35)31(29(25)34,18-16-21(3)4)19-17-22(5)6/h9-10,12-13,20-22,33-34H,8,11,14-19H2,1-7H3 CBZRNSZXQWXCGH-UHFFFAOYSA-N 466518 US10800725, Compound 6 DNA-directed RNA polymerase subunit alpha 3400 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466518&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691639 441576224 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963672 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccccc2C)=C1O InChI=1S/C31H46O4/c1-20(2)12-14-25-28(33)27(26(32)15-13-24-11-9-8-10-23(24)7)30(35)31(29(25)34,18-16-21(3)4)19-17-22(5)6/h8-11,20-22,33-34H,12-19H2,1-7H3 CMHUWSOHWCINTB-UHFFFAOYSA-N 466519 US10800725, Compound 7 DNA-directed RNA polymerase subunit alpha 1100 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466519&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691272 441576225 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963675 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2cccc(C)c2)=C1O InChI=1S/C31H46O4/c1-20(2)11-13-25-28(33)27(26(32)14-12-24-10-8-9-23(7)19-24)30(35)31(29(25)34,17-15-21(3)4)18-16-22(5)6/h8-10,19-22,33-34H,11-18H2,1-7H3 GLUDCZBHVZWTDO-UHFFFAOYSA-N 466520 US10800725, Compound 8 DNA-directed RNA polymerase subunit alpha 2200 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466520&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691429 441576226 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963678 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccc(C)cc2)=C1O InChI=1S/C31H46O4/c1-20(2)8-14-25-28(33)27(26(32)15-13-24-11-9-23(7)10-12-24)30(35)31(29(25)34,18-16-21(3)4)19-17-22(5)6/h9-12,20-22,33-34H,8,13-19H2,1-7H3 ZPBJFACDZOWNFH-UHFFFAOYSA-N 466521 US10800725, Compound 9 DNA-directed RNA polymerase subunit alpha 840 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466521&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691116 441576227 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963681 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccc(F)cc2)=C1O InChI=1S/C30H43FO4/c1-19(2)7-13-24-27(33)26(25(32)14-10-22-8-11-23(31)12-9-22)29(35)30(28(24)34,17-15-20(3)4)18-16-21(5)6/h8-9,11-12,19-21,33-34H,7,10,13-18H2,1-6H3 DHAYDKCDWYMVOY-UHFFFAOYSA-N 466522 US10800725, Compound 10 DNA-directed RNA polymerase subunit alpha 2200 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466522&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691680 441576228 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963684 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccc(Br)cc2)=C1O InChI=1S/C30H43BrO4/c1-19(2)7-13-24-27(33)26(25(32)14-10-22-8-11-23(31)12-9-22)29(35)30(28(24)34,17-15-20(3)4)18-16-21(5)6/h8-9,11-12,19-21,33-34H,7,10,13-18H2,1-6H3 LCABZLNTTVDDJJ-UHFFFAOYSA-N 466523 US10800725, Compound 11 DNA-directed RNA polymerase subunit alpha 3300 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466523&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691252 441576229 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963687 CC(C)CCC1=C(O)C(CCC(C)C)(CCC(C)C)C(=O)C(C(=O)CCc2ccc(cc2)C(F)(F)F)=C1O InChI=1S/C31H43F3O4/c1-19(2)7-13-24-27(36)26(25(35)14-10-22-8-11-23(12-9-22)31(32,33)34)29(38)30(28(24)37,17-15-20(3)4)18-16-21(5)6/h8-9,11-12,19-21,36-37H,7,10,13-18H2,1-6H3 QIKBWEPWIZQIPO-UHFFFAOYSA-N 466524 US10800725, Compound 12 DNA-directed RNA polymerase subunit alpha 460 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466524&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691431 441576230 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963690 CCCC1=C(O)C(CCC)(CCC)C(=O)C(C(=O)CCc2ccc(Cl)cc2)=C1O InChI=1S/C24H31ClO4/c1-4-7-18-21(27)20(19(26)13-10-16-8-11-17(25)12-9-16)23(29)24(14-5-2,15-6-3)22(18)28/h8-9,11-12,27-28H,4-7,10,13-15H2,1-3H3 MIXBWOOUCKLOMR-UHFFFAOYSA-N 466525 US10800725, Compound 13 DNA-directed RNA polymerase subunit alpha 5300 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466525&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691668 441576231 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45 963693 CCCCC1=C(O)C(CCCC)(CCCC)C(=O)C(C(=O)CCc2ccc(Cl)cc2)=C1O InChI=1S/C27H37ClO4/c1-4-7-10-21-24(30)23(22(29)16-13-19-11-14-20(28)15-12-19)26(32)27(25(21)31,17-8-5-2)18-9-6-3/h11-12,14-15,30-31H,4-10,13,16-18H2,1-3H3 OUPRPSHHRXTREN-UHFFFAOYSA-N 466526 US10800725, Compound 14 DNA-directed RNA polymerase subunit alpha 3100 US Patent 10.7270/Q2GB274V aid1804878 US10800725 Ebright, RH; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=953&target=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466526&enzyme=DNA-directed+RNA+polymerase+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 66691196 441576232 1 MIEIEKPRIETIEISEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKQLALKIYSEEDKTLEIDVRDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKIRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVGLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED 3GFK DNA-directed RNA polymerase subunit alpha RPOA_STAAN P66706 Q99S45