BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 11558 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Mitogen-activated protein kinase 1 Rattus norvegicus 19400 Curated from the literature by BindingDB 10.1021/jm050267e 10.7270/Q22F7KNX 15974571 aid1795974 Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK Johnson & Johnson Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 11559 Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F InChI=1S/C16H14F2N6O3S/c1-8-2-7-11(17)12(13(8)18)14(25)24-15(19)22-16(23-24)21-9-3-5-10(6-4-9)28(20,26)27/h2-7H,1H3,(H2,20,26,27)(H3,19,21,22,23) IEWLQUDDCQIINQ-UHFFFAOYSA-N 6867 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c::4-({5-amino-1-[(2,6-difluoro-3-methylphenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluoro-3-methylbenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide Mitogen-activated protein kinase 1 Rattus norvegicus 9500 Curated from the literature by BindingDB 10.1021/jm050267e 10.7270/Q22F7KNX 15974571 aid1795974 Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK Johnson & Johnson Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6867&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 5330800 8036432 ZINC12352706 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 11560 Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N InChI=1S/C14H14N6O3S2/c1-8-6-7-24-11(8)12(21)20-13(15)18-14(19-20)17-9-2-4-10(5-3-9)25(16,22)23/h2-7H,1H3,(H2,16,22,23)(H3,15,17,18,19) KQWTXAWKBUUOMU-UHFFFAOYSA-N 6870 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f::4-({5-amino-1-[(3-methylthiophen-2-yl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide Mitogen-activated protein kinase 1 Rattus norvegicus 5900 Curated from the literature by BindingDB 10.1021/jm050267e 10.7270/Q22F7KNX 15974571 aid1795974 Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK Johnson & Johnson Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6870&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 5330804 8036436 ZINC01553111 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 11561 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23) ARIOBGGRZJITQX-UHFFFAOYSA-N 6878 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n::5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide Mitogen-activated protein kinase 1 Rattus norvegicus 1000 Curated from the literature by BindingDB 10.1021/jm050267e 10.7270/Q22F7KNX 15974571 aid1795974 Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK Johnson & Johnson Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6878&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search DKI 3LJ1,2CHL,4FZF,4AAA,2J51,3HMI,2JFL,4QMP,2W4O,2WU6 5330812 8036444 DB07664 5946 ZINC12355112 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 27910 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 1 Rattus norvegicus >1000000 7.5 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(98)00113-0 10.7270/Q2XP7351 9753691 aid1797364 Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ University of Texas at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 27911 Fc1ccc(cc1)-c1ncn(CC2CC2)c1-c1ccncc1 InChI=1S/C18H16FN3/c19-16-5-3-14(4-6-16)17-18(15-7-9-20-10-8-15)22(12-21-17)11-13-1-2-13/h3-10,12-13H,1-2,11H2 ROKOFZNQCIIJMI-UHFFFAOYSA-N 15237 4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine::CHEMBL96741::PYRIDINYLIMIDAZOLE::SB2::SB216995 Mitogen-activated protein kinase 1 Rattus norvegicus >100000 7.5 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(98)00113-0 10.7270/Q2XP7351 9753691 aid1797364 Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ University of Texas at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15237&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search SB6 1BL6 5171 46515544 CHEMBL96741 DB08522 ZINC02047872 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 27913 Nc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1 InChI=1S/C18H19FN6/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24) VSPFURGQAYMVAN-UHFFFAOYSA-N 15239 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine::4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-amine::CHEMBL274064::SB220025::SB4 Mitogen-activated protein kinase 1 Rattus norvegicus 18000 7.5 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(98)00113-0 10.7270/Q2XP7351 9753691 aid1797364 Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ University of Texas at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15239&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search SB4 3ERK,6Y7W,6Y7Z,6Y7X,4LOP,4LOO,6SOV,6YCU,6Y7Y,1BL7,6SP9,6SPL,6Y85,6Y82,6Y81,6Y80,5O90,4LOQ,6Y8H,6YCW 5164 46515546 CHEMBL274064 DB04338 6038 ZINC00007258 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 27914 Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12 InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20) GTVPOLSIJWJJNY-UHFFFAOYSA-N 5718 2,6,9-Trisubstituted purine deriv. 26::2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol::2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol::6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine::CHEMBL280074::Olomoucine::purine deriv. 5 Mitogen-activated protein kinase 1 Rattus norvegicus 27000 7.5 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(98)00113-0 10.7270/Q2XP7351 9753691 aid1797364 Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ University of Texas at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5718&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search OLO 1W0X,4ERK 4592 8035333 CHEMBL280074 DB02116 ZINC01641925 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 27912 Nc1nccc(n1)-c1c(ncn1CC1CC1)-c1ccc(F)cc1 InChI=1S/C17H16FN5/c18-13-5-3-12(4-6-13)15-16(14-7-8-20-17(19)22-14)23(10-21-15)9-11-1-2-11/h3-8,10-11H,1-2,9H2,(H2,19,20,22) DFEYXQGDDCDXJK-UHFFFAOYSA-N 15238 4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine::C14316::SB218655::SB3 Mitogen-activated protein kinase 1 Rattus norvegicus >100000 7.5 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(98)00113-0 10.7270/Q2XP7351 9753691 aid1797364 Wang, Z; Canagarajah, BJ; Boehm, JC; Kassisa, S; Cobb, MH; Young, PR; Abdel-Meguid, S; Adams, JL; Goldsmith, EJ University of Texas at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15238&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search SB5 1BMK 5172 46515545 DB03980 C14316 ZINC02047865 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512311 Nc1ncc(-c2ccc(cc2)C(F)(F)F)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C19H13F3N4/c20-19(21,22)12-7-5-11(6-8-12)14-9-25-18(23)26-17(14)15-10-24-16-4-2-1-3-13(15)16/h1-10,24H,(H2,23,25,26) MFDANRLNPBAUHU-UHFFFAOYSA-N 50295874 4-(1H-indol-3-yl)-5-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine::CHEMBL550658 Mitogen-activated protein kinase 1 Rattus norvegicus 580 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295874&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45270882 104137405 CHEMBL550658 ZINC43020232 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512315 Cn1cc(-c2nc(N)ncc2-c2ccncc2)c2ccccc12 InChI=1S/C18H15N5/c1-23-11-15(13-4-2-3-5-16(13)23)17-14(10-21-18(19)22-17)12-6-8-20-9-7-12/h2-11H,1H3,(H2,19,21,22) CMCICLOFEOTOBQ-UHFFFAOYSA-N 50295878 4-(1-Methyl-1H-indol-3-yl)-5-(pyridin-4-yl)pyrimidin-2-amine::CHEMBL563962 Mitogen-activated protein kinase 1 Rattus norvegicus 1300 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295878&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 44241599 104137409 CHEMBL563962 ZINC43015537 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512317 NC(=O)c1ccc(cc1)-c1cnc(N)nc1-c1c[nH]c2ccccc12 InChI=1S/C19H15N5O/c20-18(25)12-7-5-11(6-8-12)14-9-23-19(21)24-17(14)15-10-22-16-4-2-1-3-13(15)16/h1-10,22H,(H2,20,25)(H2,21,23,24) XWNKQLLEHLJVHH-UHFFFAOYSA-N 50295873 4-[2-Amino-4-(1H-indol-3-yl)pyrimidin-5-yl]benzamide::CHEMBL559591 Mitogen-activated protein kinase 1 Rattus norvegicus 1900 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295873&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45269114 104137404 CHEMBL559591 ZINC43120335 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512324 COc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2ccccc12 InChI=1S/C19H16N4O/c1-24-13-6-4-5-12(9-13)15-10-22-19(20)23-18(15)16-11-21-17-8-3-2-7-14(16)17/h2-11,21H,1H3,(H2,20,22,23) SXTHIGQEJGIFGG-UHFFFAOYSA-N 50295875 4-(1H-Indol-3-yl)-5-(3-methoxyphenyl)pyrimidin-2-amine::CHEMBL552407 Mitogen-activated protein kinase 1 Rattus norvegicus 3100 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295875&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45270066 104137406 CHEMBL552407 ZINC43011494 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512326 Nc1ncc(-c2ccc(OC(F)(F)F)cc2)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C19H13F3N4O/c20-19(21,22)27-12-7-5-11(6-8-12)14-9-25-18(23)26-17(14)15-10-24-16-4-2-1-3-13(15)16/h1-10,24H,(H2,23,25,26) CPJHSQQFFZFVLU-UHFFFAOYSA-N 50295881 4-(1H-indol-3-yl)-5-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine::CHEMBL562648 Mitogen-activated protein kinase 1 Rattus norvegicus 3200 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295881&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45272600 104137412 CHEMBL562648 ZINC43079317 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512327 Cn1cc(-c2nc(N)ncc2I)c2ccccc12 InChI=1S/C13H11IN4/c1-18-7-9(8-4-2-3-5-11(8)18)12-10(14)6-16-13(15)17-12/h2-7H,1H3,(H2,15,16,17) UBGVTDYQKHFKNI-UHFFFAOYSA-N 50295872 5-Iodo-4-(1-Methyl-1H-indol-3-yl)pyrimidin-2-amine::CHEMBL552324 Mitogen-activated protein kinase 1 Rattus norvegicus 4000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295872&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 44241600 104137403 CHEMBL552324 ZINC43024825 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512330 Nc1cccc(c1)-c1cnc(N)nc1-c1c[nH]c2ccccc12 InChI=1S/C18H15N5/c19-12-5-3-4-11(8-12)14-9-22-18(20)23-17(14)15-10-21-16-7-2-1-6-13(15)16/h1-10,21H,19H2,(H2,20,22,23) RVBRFMSEHNINPW-UHFFFAOYSA-N 50295876 4-(1H-Indol-3-yl)-5-(3-aminophenyl)pyrimidin-2-amine::CHEMBL559734 Mitogen-activated protein kinase 1 Rattus norvegicus 6900 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295876&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45268326 104137407 CHEMBL559734 ZINC43078043 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512331 Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)C(N)=O)c2ccccc12 InChI=1S/C20H17N5O/c1-25-11-16(14-4-2-3-5-17(14)25)18-15(10-23-20(22)24-18)12-6-8-13(9-7-12)19(21)26/h2-11H,1H3,(H2,21,26)(H2,22,23,24) AWDMKXGBNZUABM-UHFFFAOYSA-N 50295880 4-[2-Amino-4-(1-methyl-1H-indol-3-yl)pyrimidin-5-yl]benzamide::CHEMBL560521 Mitogen-activated protein kinase 1 Rattus norvegicus 7000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295880&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45268224 104137411 CHEMBL560521 ZINC43078850 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512345 CC(=O)c1ccc(cc1)-c1cnc(N)nc1-c1cn(C)c2ccccc12 InChI=1S/C21H18N4O/c1-13(26)14-7-9-15(10-8-14)17-11-23-21(22)24-20(17)18-12-25(2)19-6-4-3-5-16(18)19/h3-12H,1-2H3,(H2,22,23,24) CYHAKLALLTXPRQ-UHFFFAOYSA-N 50295884 1-(4-(2-amino-4-(1-methyl-1H-indol-3-yl)pyrimidin-5-yl)phenyl)ethanone::CHEMBL560787 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295884&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45269195 104137415 CHEMBL560787 ZINC43078955 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512346 Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)-c2ccccc2)c2ccccc12 InChI=1S/C25H20N4/c1-29-16-22(20-9-5-6-10-23(20)29)24-21(15-27-25(26)28-24)19-13-11-18(12-14-19)17-7-3-2-4-8-17/h2-16H,1H3,(H2,26,27,28) CVIMBUQNJRLCFV-UHFFFAOYSA-N 50295885 5-(biphenyl-4-yl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine::CHEMBL559538 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295885&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45268325 104137416 CHEMBL559538 ZINC43080166 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512347 COc1cccc(c1)-c1cnc(N)nc1-c1cn(C)c2ccccc12 InChI=1S/C20H18N4O/c1-24-12-17(15-8-3-4-9-18(15)24)19-16(11-22-20(21)23-19)13-6-5-7-14(10-13)25-2/h3-12H,1-2H3,(H2,21,22,23) PBXJKVHTYJCPRX-UHFFFAOYSA-N 50295882 4-(1-Methyl-1H-indol-3-yl)-5-(3-methoxyphenyl)pyrimidin-2-amine::CHEMBL538190 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295882&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45271731 104137413 CHEMBL538190 ZINC42924227 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512348 Cn1cc(-c2nc(N)ncc2-c2cccc(N)c2)c2ccccc12 InChI=1S/C19H17N5/c1-24-11-16(14-7-2-3-8-17(14)24)18-15(10-22-19(21)23-18)12-5-4-6-13(20)9-12/h2-11H,20H2,1H3,(H2,21,22,23) YXAORXPHJOQBAP-UHFFFAOYSA-N 50295879 4-(1-Methyl-1H-indol-3-yl)-5-(3-aminophenyl)pyrimidin-2-amine::CHEMBL559735 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295879&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45268327 104137410 CHEMBL559735 ZINC43121257 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512349 Cn1cc(-c2nc(N)ncc2-c2ccc(cc2)C(O)=O)c2ccccc12 InChI=1S/C20H16N4O2/c1-24-11-16(14-4-2-3-5-17(14)24)18-15(10-22-20(21)23-18)12-6-8-13(9-7-12)19(25)26/h2-11H,1H3,(H,25,26)(H2,21,22,23) KQLPIHFVVIWKMP-UHFFFAOYSA-N 50295877 4-[2-Amino-4-(1-methyl-1H-indol-3-yl)pyrimidin-5-yl]benzoic acid::CHEMBL563961 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295877&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45269115 104137408 CHEMBL563961 ZINC43118564 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50512350 Cn1cc(-c2nc(N)ncc2-c2cncnc2)c2ccccc12 InChI=1S/C17H14N6/c1-23-9-14(12-4-2-3-5-15(12)23)16-13(8-21-17(18)22-16)11-6-19-10-20-7-11/h2-10H,1H3,(H2,18,21,22) ANVSLTNBCKBMMB-UHFFFAOYSA-N 50295883 4-(1-Methyl-1H-indol-3-yl)-5,50-bipyrimidin-2-amine::CHEMBL559592 Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1016/j.bmc.2009.05.017 10.7270/Q2639PSH 19477650 Akue-Gedu, R; Debiton, E; Ferandin, Y; Meijer, L; Prudhomme, M; Anizon, F; Moreau, P Clermont Universit£ http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50295883&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 45269116 104137414 CHEMBL559592 ZINC43067421 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50957192 C[C@H]1[C@@H](C)[C@H](O[C@@H]1c1ccc2OCOc2c1)c1ccc2OCOc2c1 InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1 QFUXQRHAJWXPGP-YLYZPZNOSA-N 50392850 CHEMBL2151191 Mitogen-activated protein kinase 1 Rattus norvegicus 295000 ChEMBL 10.1021/ml300129b 10.7270/Q2ZG6T9C 23002419 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392850&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 12310041 163341874 CHEMBL2151191 ZINC14860234 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50957193 Nc1[nH]n2c(nc(N)c3c(N)nnc23)c1NNc1ccc(Br)cc1 InChI=1S/C13H13BrN10/c14-5-1-3-6(4-2-5)19-20-8-11(17)23-24-12-7(10(16)21-22-12)9(15)18-13(8)24/h1-4,19-20,23H,15,17H2,(H2,16,21) WCIHXTVKFSXTCT-UHFFFAOYSA-N 50392851 CHEMBL2151192 Mitogen-activated protein kinase 1 Rattus norvegicus 4600 ChEMBL 10.1021/ml300129b 10.7270/Q2ZG6T9C 23002419 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392851&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91929580 163341875 CHEMBL2151192 ZINC95571852 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50957194 COc1ccc(cc1)-c1nnc2sc3c(ccc4ccccc34)n12 InChI=1S/C19H13N3OS/c1-23-14-9-6-13(7-10-14)18-20-21-19-22(18)16-11-8-12-4-2-3-5-15(12)17(16)24-19/h2-11H,1H3 HLIMLOCFQJDVDJ-UHFFFAOYSA-N 50392852 CHEMBL2151193 Mitogen-activated protein kinase 1 Rattus norvegicus 7500 ChEMBL 10.1021/ml300129b 10.7270/Q2ZG6T9C 23002419 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392852&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 331326 163341876 CHEMBL2151193 ZINC01572936 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50957195 OC(=O)C(CC(=O)c1ccc2OCOc2c1)c1ccc2OCOc2c1 InChI=1S/C18H14O7/c19-13(11-2-4-15-17(6-11)25-9-23-15)7-12(18(20)21)10-1-3-14-16(5-10)24-8-22-14/h1-6,12H,7-9H2,(H,20,21) PPEBBOHQEAQKSW-UHFFFAOYSA-N 50392853 CHEMBL2000337 Mitogen-activated protein kinase 1 Rattus norvegicus 57000 ChEMBL 10.1021/ml300129b 10.7270/Q2ZG6T9C 23002419 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392853&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 294348 163341877 CHEMBL2000337 ZINC06513489 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50957196 Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc2OCOc2c1 InChI=1S/C14H11N5O4/c1-18-13(20)10-12(16-14(18)21)19(2)17-11(15-10)7-3-4-8-9(5-7)23-6-22-8/h3-5H,6H2,1-2H3 FEQRWFABERLIOV-UHFFFAOYSA-N 50392849 CHEMBL2151190::US9073941, 612 Mitogen-activated protein kinase 1 Rattus norvegicus 1000 ChEMBL 10.1021/ml300129b 10.7270/Q2ZG6T9C 23002419 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392849&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 322479 163341873 CHEMBL2151190 ZINC00800346 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50972118 O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21) PGPHHJBZEGSUNE-UHFFFAOYSA-N 50347750 CHEMBL1802358 Mitogen-activated protein kinase 1 Rattus norvegicus >30000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347750&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 25230621 136354436 CHEMBL1802358 ZINC59182036 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50972137 CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O InChI=1S/C12H11N3O3/c1-15-11(16)8(14-12(15)13)4-7-2-3-9-10(5-7)18-6-17-9/h2-5H,6H2,1H3,(H2,13,14) PKEDBIGNILOTHW-UHFFFAOYSA-N 50292406 CHEMBL485053::leucettamine B Mitogen-activated protein kinase 1 Rattus norvegicus >10000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50292406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50292406&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 10037501 104133957 CHEMBL485053 ZINC34118117 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 50972156 COc1ccc2c(c1)[nH]c1c(C)nccc21 InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 BXNJHAXVSOCGBA-UHFFFAOYSA-N 100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389 Mitogen-activated protein kinase 1 Rattus norvegicus >30000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100152&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search HRM 7X9D,5Y86,2Z5X,3ANR,2Z5Y 5280953 252663240 28121 DB07919 C06538 ZINC18847046 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314376 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)OCc3ccccc3)ncc12 InChI=1S/C20H17N5O2/c1-13-9-15(7-8-21-13)19-16-11-22-18(10-17(16)24-25-19)23-20(26)27-12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,24,25)(H,22,23,26) ZPGZHORODFWDFX-UHFFFAOYSA-N 50532686 CHEMBL4442628 Mitogen-activated protein kinase 1 Rattus norvegicus >3000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532686&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155515786 440741268 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314378 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)OCc3ccccc3)ccc12 InChI=1S/C21H18N4O2/c1-14-11-16(9-10-22-14)20-18-8-7-17(12-19(18)24-25-20)23-21(26)27-13-15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H,23,26)(H,24,25) WWUMBMALEWSGCB-UHFFFAOYSA-N 50532687 CHEMBL4565327 Mitogen-activated protein kinase 1 Rattus norvegicus >3000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532687&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155544785 440741269 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314391 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccccc3)ncc12 InChI=1S/C20H18N6O/c1-13-9-15(7-8-21-13)19-16-12-22-18(10-17(16)25-26-19)24-20(27)23-11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,25,26)(H2,22,23,24,27) XNCYRRXMFCUPKS-UHFFFAOYSA-N 50437406 CHEMBL2408788::US9023865, 9 Mitogen-activated protein kinase 1 Rattus norvegicus 0.200000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437406&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 6S9 5KE0 71555247 175449723 CHEMBL2408788 ZINC96273266 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314392 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)CCc3ccccc3)ncc12 InChI=1S/C21H19N5O/c1-14-11-16(9-10-22-14)21-17-13-23-19(12-18(17)25-26-21)24-20(27)8-7-15-5-3-2-4-6-15/h2-6,9-13H,7-8H2,1H3,(H,25,26)(H,23,24,27) AIJHKEJKGWZNFV-UHFFFAOYSA-N 50532690 CHEMBL4535851 Mitogen-activated protein kinase 1 Rattus norvegicus 420 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532690&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155547655 440741272 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314393 C[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 157162 US9023865, 7 Mitogen-activated protein kinase 1 Rattus norvegicus 38 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157162&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555245 254814406 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314408 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)CCc3ccccc3)ncc12 InChI=1S/C21H19N5O/c1-14-11-16(9-10-22-14)21-17-13-23-19(12-18(17)25-26-21)24-20(27)8-7-15-5-3-2-4-6-15/h2-6,9-13H,7-8H2,1H3,(H,25,26)(H,23,24,27) AIJHKEJKGWZNFV-UHFFFAOYSA-N 50532690 CHEMBL4535851 Mitogen-activated protein kinase 1 Rattus norvegicus 420 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532690&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155547655 440741272 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314409 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)OCc3ccccc3)ccc12 InChI=1S/C21H18N4O2/c1-14-11-16(9-10-22-14)20-18-8-7-17(12-19(18)24-25-20)23-21(26)27-13-15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H,23,26)(H,24,25) WWUMBMALEWSGCB-UHFFFAOYSA-N 50532687 CHEMBL4565327 Mitogen-activated protein kinase 1 Rattus norvegicus >3000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532687&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155544785 440741269 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314410 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCCc3ccccc3)ncc12 InChI=1S/C21H20N6O/c1-14-11-16(8-10-22-14)20-17-13-24-19(12-18(17)26-27-20)25-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-13H,7,9H2,1H3,(H,26,27)(H2,23,24,25,28) SXHJFLZPXBCHPC-UHFFFAOYSA-N 157161 US9023865, 5 Mitogen-activated protein kinase 1 Rattus norvegicus 0.500000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157161&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555243 254814405 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314425 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)OCc3ccccc3)ncc12 InChI=1S/C20H17N5O2/c1-13-9-15(7-8-21-13)19-16-11-22-18(10-17(16)24-25-19)23-20(26)27-12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,24,25)(H,22,23,26) ZPGZHORODFWDFX-UHFFFAOYSA-N 50532686 CHEMBL4442628 Mitogen-activated protein kinase 1 Rattus norvegicus >3000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532686&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 155515786 440741268 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314429 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCc3ccccc3)ncc12 InChI=1S/C20H18N6O/c1-13-9-15(7-8-21-13)19-16-12-22-18(10-17(16)25-26-19)24-20(27)23-11-14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,25,26)(H2,22,23,24,27) XNCYRRXMFCUPKS-UHFFFAOYSA-N 50437406 CHEMBL2408788::US9023865, 9 Mitogen-activated protein kinase 1 Rattus norvegicus 0.200000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437406&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 6S9 5KE0 71555247 175449723 CHEMBL2408788 ZINC96273266 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314430 C[C@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2cn1)c1ccccc1 157162 US9023865, 7 Mitogen-activated protein kinase 1 Rattus norvegicus 38 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157162&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555245 254814406 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51314438 Cc1cc(ccn1)-c1n[nH]c2cc(NC(=O)NCCc3ccccc3)ncc12 InChI=1S/C21H20N6O/c1-14-11-16(8-10-22-14)20-17-13-24-19(12-18(17)26-27-20)25-21(28)23-9-7-15-5-3-2-4-6-15/h2-6,8,10-13H,7,9H2,1H3,(H,26,27)(H2,23,24,25,28) SXHJFLZPXBCHPC-UHFFFAOYSA-N 157161 US9023865, 5 Mitogen-activated protein kinase 1 Rattus norvegicus 0.500000 ChEMBL 10.1021/acs.jmedchem.6b00708 10.7270/Q2J969VW 27329786 Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Merck & Co., Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=157161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=157161&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 71555243 254814405 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703 51494279 Oc1nnc(Sc2ncc(s2)[N+]([O-])=O)n1-c1ccc2OCCOc2c1 InChI=1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19) QFRLDZGQEZCCJZ-UHFFFAOYSA-N 50526695 BI-78D3::CHEMBL508280 Mitogen-activated protein kinase 1 Rattus norvegicus 2300 ChEMBL 10.7270/Q2HT2TF2 36205714 Fu, L; Chen, S; He, G; Chen, Y; Liu, B Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=943&target=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526695&enzyme=Mitogen-activated+protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 2747117 440735277 1 MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 1ERK,2ERK,2FYS,2Z7L,3C9W,3ERK,3O71,3QYW,3QYZ,3TEI,3ZU7,3ZUV,4ERK,4GSB,4GT3,4GVA,4H3P,4QYY,4S31,4S32,4XNE,4XOY,4XOZ,4XP0,4XP2,4XP3,4XRJ,4XRL,4ZZM,4ZZN,4ZZO,5HD4,5KE0,5U6I,5UMO,6CPW,6DCG,6FI3,6FI6,6FJ0,6FJB,6FJZ,6FLE,6FLV,6FMA,6FN5,6FQ7,6FR1,6FRP,6FXV,6NBS,6OPK,7UGB Mitogen-activated protein kinase 1 MK01_RAT P63086 P27703