BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 387221 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C26H18Cl3N3O2/c1-32-15-30-14-22(32)26(33,16-7-10-18(27)11-8-16)17-9-12-21-20(13-17)23(28)24(25(29)31-21)34-19-5-3-2-4-6-19/h2-15,33H,1H3 AAFZIZYKCOZVIE-UHFFFAOYSA-N 221227 US9303015, 1 Nuclear receptor ROR-gamma [258-518,Y502F] 670 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221227&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223686 335960302 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387222 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518,Y502F] 410 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387223 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518,Y502F] 370 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387224 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518,Y502F] 260 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387225 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl2N3O3/c1-3-35-27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(34,24-16-31-17-33(24)2)18-9-12-20(29)13-10-18/h4-17,34H,3H2,1-2H3 UYBIBQBVLKWEAI-UHFFFAOYSA-N 221228 US9303015, 2a::US9303015, 2b::US9303015, 2c Nuclear receptor ROR-gamma [258-518,Y502F] 400 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221228&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223688 335960303 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387226 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518,Y502F] 120 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387227 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518,Y502F] 1400 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387228 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H28Cl2N4O2/c1-4-36(5-2)29-28(38-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)34-29)30(37,26-18-33-19-35(26)3)20-11-14-22(31)15-12-20/h6-19,37H,4-5H2,1-3H3 QSNQBKVAYOUNKI-UHFFFAOYSA-N 221229 US9303015, 3a::US9303015, 3b::US9303015, 3c Nuclear receptor ROR-gamma [258-518,Y502F] 160 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221229&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223742 335960304 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387229 COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(Cl)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C26H20Cl2N4O3/c1-32-15-29-14-21(32)26(33,17-9-11-22(34-2)30-13-17)16-8-10-20-19(12-16)23(27)24(25(28)31-20)35-18-6-4-3-5-7-18/h3-15,33H,1-2H3 IHOMEIUZNUWVSU-UHFFFAOYSA-N 221230 US9303015, 4 Nuclear receptor ROR-gamma [258-518,Y502F] 670 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223744 335960305 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387230 COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(Cl)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C26H20Cl2N4O3/c1-32-15-29-14-21(32)26(33,17-9-11-22(34-2)30-13-17)16-8-10-20-19(12-16)23(27)24(25(28)31-20)35-18-6-4-3-5-7-18/h3-15,33H,1-2H3 IHOMEIUZNUWVSU-UHFFFAOYSA-N 221230 US9303015, 4 Nuclear receptor ROR-gamma [258-518,Y502F] 500 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221230&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223744 335960305 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387231 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518,Y502F] 100 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387232 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518,Y502F] 39 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387233 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C30H30ClN5O3/c1-5-36(6-2)29-28(39-22-10-8-7-9-11-22)27(31)23-16-20(12-14-24(23)34-29)30(37,25-18-32-19-35(25)3)21-13-15-26(38-4)33-17-21/h7-19,37H,5-6H2,1-4H3 OBAXSFJDXZIJNI-UHFFFAOYSA-N 221231 US9303015, 5a::US9303015, 5b::US9303015, 5c Nuclear receptor ROR-gamma [258-518,Y502F] 28 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221231&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223687 335960306 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387234 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518,Y502F] 85 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387235 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518,Y502F] 81 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387236 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O2/c1-4-39(5-2)28-27(41-21-9-7-6-8-10-21)26(31)22-15-19(11-13-23(22)37-28)29(40,25-17-35-18-38(25)3)20-12-14-24(36-16-20)30(32,33)34/h6-18,40H,4-5H2,1-3H3 LFUGPNMUNFREIQ-UHFFFAOYSA-N 221232 US9303015, 6a::US9303015, 6b::US9303015, 6c Nuclear receptor ROR-gamma [258-518,Y502F] 270 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221232&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223741 335960307 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387237 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C31H27Cl2N3O2/c1-3-36(4-2)30-29(38-25-13-6-5-7-14-25)28(33)26-19-22(15-16-27(26)35-30)31(37,23-11-9-17-34-20-23)21-10-8-12-24(32)18-21/h5-20,37H,3-4H2,1-2H3 QFGGXRYCVZZIMH-UHFFFAOYSA-N 221233 US9303015, 7 Nuclear receptor ROR-gamma [258-518,Y502F] 72 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221233&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223743 335960308 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387238 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncs1)c1cncn1C InChI=1S/C27H26ClN5O2S/c1-4-33(5-2)26-25(35-19-9-7-6-8-10-19)24(28)20-13-18(11-12-21(20)31-26)27(34,23-15-30-17-36-23)22-14-29-16-32(22)3/h6-17,34H,4-5H2,1-3H3 VAUSKCYWXYGVQL-UHFFFAOYSA-N 221234 US9303015, 8 Nuclear receptor ROR-gamma [258-518,Y502F] 16 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221234&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223745 335960309 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387239 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 300 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387240 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 220 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387241 CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H26ClF4N5O2/c1-4-40(5-2)28-27(42-21-10-8-20(32)9-11-21)26(31)22-14-18(6-12-23(22)38-28)29(41,25-16-36-17-39(25)3)19-7-13-24(37-15-19)30(33,34)35/h6-17,41H,4-5H2,1-3H3 AXVBVFNCJWQPMU-UHFFFAOYSA-N 221235 US9303015, 9a::US9303015, 9b::US9303015, 9c Nuclear receptor ROR-gamma [258-518,Y502F] 66 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221235&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223794 335960310 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387242 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 87 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387243 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 92 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387244 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C28H25ClN4O4/c1-4-36-27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(34,23-16-30-17-33(23)2)19-11-13-24(35-3)31-15-19/h5-17,34H,4H2,1-3H3 RCZIUKXBTCTDBV-UHFFFAOYSA-N 221236 US9303015, 10a::US9303015, 10b::US9303015, 10c Nuclear receptor ROR-gamma [258-518,Y502F] 270 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221236&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223796 335960311 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387245 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387246 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 1100 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387247 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 700 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387248 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387249 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] 1000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387250 CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C28H21ClF4N4O3/c1-3-39-26-25(40-19-8-6-18(30)7-9-19)24(29)20-12-16(4-10-21(20)36-26)27(38,23-14-34-15-37(23)2)17-5-11-22(35-13-17)28(31,32)33/h4-15,38H,3H2,1-2H3 CXEVNMJGHDDSGJ-UHFFFAOYSA-N 221240 US9303015, 14a::US9303015, 14b::US9303015, 14c Nuclear receptor ROR-gamma [258-518,Y502F] >6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221240&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223889 335960312 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387251 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518,Y502F] 750 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387252 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387253 COc1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(31-22)34-2)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 DMNDKESGHYMQPJ-UHFFFAOYSA-N 221241 US9303015, 15a::US9303015, 15b::US9303015, 15c Nuclear receptor ROR-gamma [258-518,Y502F] 700 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221241&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223795 335960313 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387254 CN(C)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H24Cl2N4O2/c1-33(2)27-26(36-21-7-5-4-6-8-21)25(30)22-15-19(11-14-23(22)32-27)28(35,24-16-31-17-34(24)3)18-9-12-20(29)13-10-18/h4-17,35H,1-3H3 AUNRETUDSHCGLM-UHFFFAOYSA-N 221242 US9303015, 16 Nuclear receptor ROR-gamma [258-518,Y502F] 360 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221242&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223797 335960314 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387255 COc1ccc(cn1)C(O)(c1cncn1C)c1ccc2nc(N(C)C)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C28H26ClN5O3/c1-33(2)27-26(37-20-8-6-5-7-9-20)25(29)21-14-18(10-12-22(21)32-27)28(35,23-16-30-17-34(23)3)19-11-13-24(36-4)31-15-19/h5-17,35H,1-4H3 TZZKHOLXWCJBLK-UHFFFAOYSA-N 221243 US9303015, 17 Nuclear receptor ROR-gamma [258-518,Y502F] 150 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221243&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223842 335960315 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387256 COc1c(Oc2ccccc2)c(Cl)nc2ccc(cc12)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl2N3O3/c1-32-16-30-15-23(32)27(33,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(34-2)25(26(29)31-22)35-20-6-4-3-5-7-20/h3-16,33H,1-2H3 SWUYOUYKNRCXJY-UHFFFAOYSA-N 221244 US9303015, 18 Nuclear receptor ROR-gamma [258-518,Y502F] 2100 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221244&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223844 335960316 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387257 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C27H18Cl2N4O2/c1-33-16-31-15-24(33)27(34,17-7-10-19(28)11-8-17)18-9-12-22-21(13-18)25(29)26(23(14-30)32-22)35-20-5-3-2-4-6-20/h2-13,15-16,34H,1H3 JYJUFLUFYWUNRJ-UHFFFAOYSA-N 221245 US9303015, 19 Nuclear receptor ROR-gamma [258-518,Y502F] 410 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221245&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223846 335960317 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387258 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 InChI=1S/C28H18ClN5O2/c1-34-17-32-16-26(34)28(35,18-7-10-20(29)11-8-18)19-9-12-24-22(13-19)23(14-30)27(25(15-31)33-24)36-21-5-3-2-4-6-21/h2-13,16-17,35H,1H3 ZIWGQMCFFKYIPD-UHFFFAOYSA-N 221246 US9303015, 20 Nuclear receptor ROR-gamma [258-518,Y502F] 110 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221246&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223890 335960318 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387259 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C27H17ClF3N5O2/c1-36-15-33-14-23(36)26(37,17-8-10-22(34-13-17)27(29,30)31)16-7-9-20-19(11-16)24(28)25(21(12-32)35-20)38-18-5-3-2-4-6-18/h2-11,13-15,37H,1H3 OMPNGQIXHAWMQG-UHFFFAOYSA-N 221247 US9303015, 21 Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221247&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223891 335960319 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387260 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(Cl)c2c1 InChI=1S/C27H17ClF3N5O2/c1-36-15-33-14-23(36)26(37,17-8-10-22(34-13-17)27(29,30)31)16-7-9-20-19(11-16)24(28)25(21(12-32)35-20)38-18-5-3-2-4-6-18/h2-11,13-15,37H,1H3 OMPNGQIXHAWMQG-UHFFFAOYSA-N 221247 US9303015, 21 Nuclear receptor ROR-gamma [258-518,Y502F] 4000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221247&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223891 335960319 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387261 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 InChI=1S/C28H17F3N6O2/c1-37-16-34-15-25(37)27(38,18-8-10-24(35-14-18)28(29,30)31)17-7-9-22-20(11-17)21(12-32)26(23(13-33)36-22)39-19-5-3-2-4-6-19/h2-11,14-16,38H,1H3 HOBABKIULJKSFW-UHFFFAOYSA-N 221248 US9303015, 22a Nuclear receptor ROR-gamma [258-518,Y502F] 6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221248&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 117868434 335960320 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387262 OC(c1cnc[nH]1)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 221289 US9303015, 22b::US9303015, 22c Nuclear receptor ROR-gamma [258-518,Y502F] 6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221289&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 126842401 335960345 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387263 OC(c1cnc[nH]1)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 221289 US9303015, 22b::US9303015, 22c Nuclear receptor ROR-gamma [258-518,Y502F] >6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221289&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 126842401 335960345 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387264 OC(c1cnc[nH]1)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccccc3)c(C#N)c2c1 221289 US9303015, 22b::US9303015, 22c Nuclear receptor ROR-gamma [258-518,Y502F] 680 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221289&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 126842401 335960345 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387265 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1 InChI=1S/C27H17Cl2FN4O2/c1-34-15-32-14-24(34)27(35,16-2-5-18(28)6-3-16)17-4-11-22-21(12-17)25(29)26(23(13-31)33-22)36-20-9-7-19(30)8-10-20/h2-12,14-15,35H,1H3 FEMFLJUOZBWZNG-UHFFFAOYSA-N 221249 US9303015, 23 Nuclear receptor ROR-gamma [258-518,Y502F] 1200 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221249&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223892 335960321 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387266 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1 InChI=1S/C27H17Cl2FN4O2/c1-34-15-32-14-24(34)27(35,16-2-5-18(28)6-3-16)17-4-11-22-21(12-17)25(29)26(23(13-31)33-22)36-20-9-7-19(30)8-10-20/h2-12,14-15,35H,1H3 FEMFLJUOZBWZNG-UHFFFAOYSA-N 221249 US9303015, 23 Nuclear receptor ROR-gamma [258-518,Y502F] 700 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221249&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223892 335960321 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387267 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1 InChI=1S/C27H17Cl2FN4O2/c1-34-15-32-14-24(34)27(35,16-2-5-18(28)6-3-16)17-4-11-22-21(12-17)25(29)26(23(13-31)33-22)36-20-9-7-19(30)8-10-20/h2-12,14-15,35H,1H3 FEMFLJUOZBWZNG-UHFFFAOYSA-N 221249 US9303015, 23 Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221249&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223892 335960321 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387268 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccc(Cl)cc3)c(c2c1)C(F)(F)F InChI=1S/C28H16ClF6N5O2/c1-40-14-37-13-23(40)26(41,16-3-9-22(38-12-16)27(30,31)32)15-2-8-20-19(10-15)24(28(33,34)35)25(21(11-36)39-20)42-18-6-4-17(29)5-7-18/h2-10,12-14,41H,1H3 PMJXQSOZVOJFLZ-UHFFFAOYSA-N 221250 US9303015, 24 Nuclear receptor ROR-gamma [258-518,Y502F] 6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221250&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223945 335960322 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387269 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccc(Cl)cc3)c(c2c1)C(F)(F)F InChI=1S/C28H16ClF6N5O2/c1-40-14-37-13-23(40)26(41,16-3-9-22(38-12-16)27(30,31)32)15-2-8-20-19(10-15)24(28(33,34)35)25(21(11-36)39-20)42-18-6-4-17(29)5-7-18/h2-10,12-14,41H,1H3 PMJXQSOZVOJFLZ-UHFFFAOYSA-N 221250 US9303015, 24 Nuclear receptor ROR-gamma [258-518,Y502F] >6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221250&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223945 335960322 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387270 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(C#N)c(Oc3ccc(Cl)cc3)c(c2c1)C(F)(F)F InChI=1S/C28H16ClF6N5O2/c1-40-14-37-13-23(40)26(41,16-3-9-22(38-12-16)27(30,31)32)15-2-8-20-19(10-15)24(28(33,34)35)25(21(11-36)39-20)42-18-6-4-17(29)5-7-18/h2-10,12-14,41H,1H3 PMJXQSOZVOJFLZ-UHFFFAOYSA-N 221250 US9303015, 24 Nuclear receptor ROR-gamma [258-518,Y502F] 5000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221250&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223945 335960322 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387271 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518,Y502F] 560 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387272 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518,Y502F] 250 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387273 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387274 CCOc1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C29H21ClF6N4O3/c1-3-42-26-25(43-19-8-6-18(30)7-9-19)24(29(34,35)36)20-12-16(4-10-21(20)39-26)27(41,23-14-37-15-40(23)2)17-5-11-22(38-13-17)28(31,32)33/h4-15,41H,3H2,1-2H3 DJTRYZOLOWBFQI-UHFFFAOYSA-N 221251 US9303015, 25a::US9303015, 25b::US9303015, 25c Nuclear receptor ROR-gamma [258-518,Y502F] 1000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221251&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223947 335960323 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387275 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C31H27Cl2F3N4O2/c1-4-40(5-2)29-28(42-23-13-11-22(33)12-14-23)27(31(34,35)36)24-16-20(8-15-25(24)38-29)30(41,26-17-37-18-39(26)3)19-6-9-21(32)10-7-19/h6-18,41H,4-5H2,1-3H3 OBMBDUORCAESAA-UHFFFAOYSA-N 221252 US9303015, 26 Nuclear receptor ROR-gamma [258-518,Y502F] 360 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221252&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223948 335960324 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387276 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518,Y502F] 210 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387277 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518,Y502F] 10 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387278 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C31H26ClF6N5O2/c1-4-43(5-2)28-27(45-21-10-8-20(32)9-11-21)26(31(36,37)38)22-14-18(6-12-23(22)41-28)29(44,25-16-39-17-42(25)3)19-7-13-24(40-15-19)30(33,34)35/h6-17,44H,4-5H2,1-3H3 LTFNIYSAZCKYLQ-UHFFFAOYSA-N 221253 US9303015, 27a::US9303015, 27b::US9303015, 27c Nuclear receptor ROR-gamma [258-518,Y502F] 95 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221253&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 73442853 335960325 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387279 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccc(Cl)cc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(OC)nc1 InChI=1S/C31H29ClF3N5O3/c1-5-40(6-2)29-28(43-22-11-9-21(32)10-12-22)27(31(33,34)35)23-15-19(7-13-24(23)38-29)30(41,25-17-36-18-39(25)3)20-8-14-26(42-4)37-16-20/h7-18,41H,5-6H2,1-4H3 FZNXQPHQEMTZMH-UHFFFAOYSA-N 221254 US9303015, 28 Nuclear receptor ROR-gamma [258-518,Y502F] 110 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221254&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223019 335960326 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387280 CCN(CC)c1nc2ccc(cc2c(c1Oc1ccccc1)C(F)(F)F)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C31H28ClF3N4O2/c1-4-39(5-2)29-28(41-23-9-7-6-8-10-23)27(31(33,34)35)24-17-21(13-16-25(24)37-29)30(40,26-18-36-19-38(26)3)20-11-14-22(32)15-12-20/h6-19,40H,4-5H2,1-3H3 ZDNAKVBXOLTMMW-UHFFFAOYSA-N 221255 US9303015, 29 Nuclear receptor ROR-gamma [258-518,Y502F] 470 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221255&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223893 335960327 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387281 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518,Y502F] 140 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387282 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518,Y502F] 31 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387283 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C29H22Cl2F3N5O2/c1-38-16-35-15-24(38)28(40,18-4-10-23(36-14-18)29(32,33)34)17-3-9-22-21(13-17)25(31)26(27(37-22)39-11-2-12-39)41-20-7-5-19(30)6-8-20/h3-10,13-16,40H,2,11-12H2,1H3 MDPNKAIDFYRNEN-UHFFFAOYSA-N 221256 US9303015, 30a::US9303015, 30b::US9303015, 30c Nuclear receptor ROR-gamma [258-518,Y502F] 58 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221256&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 86715463 335960328 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387284 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518,Y502F] 88 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387285 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518,Y502F] 18 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387286 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H22ClF3N6O2/c1-39-17-36-16-25(39)29(41,20-6-10-24(37-15-20)30(32,33)34)19-5-9-23-22(13-19)26(31)27(28(38-23)40-11-2-12-40)42-21-7-3-18(14-35)4-8-21/h3-10,13,15-17,41H,2,11-12H2,1H3 HGMJOSNOVDDGAZ-UHFFFAOYSA-N 221257 US9303015, 31a::US9303015, 31b::US9303015, 31c Nuclear receptor ROR-gamma [258-518,Y502F] 190 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221257&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223946 335960329 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387287 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518,Y502F] 72 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387288 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518,Y502F] 120 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387289 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(N3CCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C30H23Cl2N5O2/c1-36-18-34-17-26(36)30(38,20-5-8-22(31)9-6-20)21-7-12-25-24(15-21)27(32)28(29(35-25)37-13-2-14-37)39-23-10-3-19(16-33)4-11-23/h3-12,15,17-18,38H,2,13-14H2,1H3 CBOYVDJPUOJMBW-UHFFFAOYSA-N 221258 US9303015, 32a::US9303015, 32b::US9303015, 32c Nuclear receptor ROR-gamma [258-518,Y502F] 66 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221258&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223017 335960330 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387290 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(N3CCCC3)c(Oc3ccc(cc3)C#N)c(Cl)c2c1 InChI=1S/C31H24ClF3N6O2/c1-40-18-37-17-26(40)30(42,21-7-11-25(38-16-21)31(33,34)35)20-6-10-24-23(14-20)27(32)28(29(39-24)41-12-2-3-13-41)43-22-8-4-19(15-36)5-9-22/h4-11,14,16-18,42H,2-3,12-13H2,1H3 XTJBVBCWFGLULK-UHFFFAOYSA-N 221259 US9303015, 33 Nuclear receptor ROR-gamma [258-518,Y502F] 280 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221259&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223018 335960331 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387291 COCCN(C)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F InChI=1S/C30H27ClF3N5O3/c1-38(13-14-41-3)28-27(42-21-7-5-4-6-8-21)26(31)22-15-19(9-11-23(22)37-28)29(40,25-17-35-18-39(25)2)20-10-12-24(36-16-20)30(32,33)34/h4-12,15-18,40H,13-14H2,1-3H3 VNLMKCKJADGMDH-UHFFFAOYSA-N 221260 US9303015, 34 Nuclear receptor ROR-gamma [258-518,Y502F] 250 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221260&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223020 335960332 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387292 CN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C28H20Cl3N3O/c1-34(22-10-3-2-4-11-22)26-25(30)23-16-19(12-13-24(23)33-27(26)31)28(35,20-8-6-14-32-17-20)18-7-5-9-21(29)15-18/h2-17,35H,1H3 CXISRSBZHJUAJP-UHFFFAOYSA-N 221261 US9303015, 35 Nuclear receptor ROR-gamma [258-518,Y502F] 100 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221261&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223021 335960333 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387293 CCOc1nc2ccc(cc2c(Cl)c1N(C)c1ccccc1)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C30H25Cl2N3O2/c1-3-37-29-28(35(2)24-12-5-4-6-13-24)27(32)25-18-21(14-15-26(25)34-29)30(36,22-10-8-16-33-19-22)20-9-7-11-23(31)17-20/h4-19,36H,3H2,1-2H3 CZNDPOIIONPSFG-UHFFFAOYSA-N 221262 US9303015, 36 Nuclear receptor ROR-gamma [258-518,Y502F] 89 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221262&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223087 335960334 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387294 CN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl3N4O/c1-33-16-31-15-23(33)27(35,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(30)32-22)34(2)20-6-4-3-5-7-20/h3-16,35H,1-2H3 WPVZONCHBLXUMN-UHFFFAOYSA-N 221264 US9303015, 38 Nuclear receptor ROR-gamma [258-518,Y502F] 520 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221264&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223091 335960336 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387295 CN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C27H21Cl3N4O/c1-33-16-31-15-23(33)27(35,17-8-11-19(28)12-9-17)18-10-13-22-21(14-18)24(29)25(26(30)32-22)34(2)20-6-4-3-5-7-20/h3-16,35H,1-2H3 WPVZONCHBLXUMN-UHFFFAOYSA-N 221264 US9303015, 38 Nuclear receptor ROR-gamma [258-518,Y502F] 1000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221264&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223091 335960336 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387296 CCN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cccnc1)c1cccc(Cl)c1 InChI=1S/C29H22Cl3N3O/c1-2-35(23-11-4-3-5-12-23)27-26(31)24-17-20(13-14-25(24)34-28(27)32)29(36,21-9-7-15-33-18-21)19-8-6-10-22(30)16-19/h3-18,36H,2H2,1H3 MDEOYKJUOUYVQF-UHFFFAOYSA-N 221265 US9303015, 39 Nuclear receptor ROR-gamma [258-518,Y502F] 170 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221265&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223160 335960337 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387297 CCN(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C28H23Cl3N4O/c1-3-35(21-7-5-4-6-8-21)26-25(30)22-15-19(11-14-23(22)33-27(26)31)28(36,24-16-32-17-34(24)2)18-9-12-20(29)13-10-18/h4-17,36H,3H2,1-2H3 QKBAPBUOFNHEOM-UHFFFAOYSA-N 221266 US9303015, 40 Nuclear receptor ROR-gamma [258-518,Y502F] 490 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221266&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223162 335960338 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387298 CC(C)N(c1ccccc1)c1c(Cl)nc2ccc(cc2c1Cl)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C29H25Cl3N4O/c1-18(2)36(22-7-5-4-6-8-22)27-26(31)23-15-20(11-14-24(23)34-28(27)32)29(37,25-16-33-17-35(25)3)19-9-12-21(30)13-10-19/h4-18,37H,1-3H3 UAQRZTVJCIBCKB-UHFFFAOYSA-N 221267 US9303015, 41 Nuclear receptor ROR-gamma [258-518,Y502F] 1000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221267&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223163 335960339 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387299 OC(c1cccnc1)(c1cccc(Cl)c1)c1ccc2nc(Cl)c(Nc3ccccc3)c(Cl)c2c1 InChI=1S/C27H18Cl3N3O/c28-20-8-4-6-17(14-20)27(34,19-7-5-13-31-16-19)18-11-12-23-22(15-18)24(29)25(26(30)33-23)32-21-9-2-1-3-10-21/h1-16,32,34H FVDNUOYVMNZOQL-UHFFFAOYSA-N 221268 US9303015, 42 Nuclear receptor ROR-gamma [258-518,Y502F] 920 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221268&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 117883602 335960340 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387300 Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(Cl)c(Nc3ccccc3)c(Cl)c2c1 InChI=1S/C26H19Cl3N4O/c1-33-15-30-14-22(33)26(34,16-7-10-18(27)11-8-16)17-9-12-21-20(13-17)23(28)24(25(29)32-21)31-19-5-3-2-4-6-19/h2-15,31,34H,1H3 PBBLAYPQLHWIDA-UHFFFAOYSA-N 221269 US9303015, 43 Nuclear receptor ROR-gamma [258-518,Y502F] 880 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221269&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223088 335960341 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387301 CCN(CC)c1nc2ccc(cc2c(Cl)c1N(C(=O)OC(C)(C)C)c1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C35H37Cl2N5O3/c1-7-41(8-2)32-31(42(26-12-10-9-11-13-26)33(43)45-34(3,4)5)30(37)27-20-24(16-19-28(27)39-32)35(44,29-21-38-22-40(29)6)23-14-17-25(36)18-15-23/h9-22,44H,7-8H2,1-6H3 PBIQIMKSLWQFDB-UHFFFAOYSA-N 221270 US9303015, 44 Nuclear receptor ROR-gamma [258-518,Y502F] 2000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221270&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223090 335960342 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387302 CCN(CC)c1nc2ccc(cc2c(Cl)c1Nc1ccccc1)C(O)(c1cncn1C)c1ccc(Cl)cc1 InChI=1S/C30H29Cl2N5O/c1-4-37(5-2)29-28(34-23-9-7-6-8-10-23)27(32)24-17-21(13-16-25(24)35-29)30(38,26-18-33-19-36(26)3)20-11-14-22(31)15-12-20/h6-19,34,38H,4-5H2,1-3H3 SRJGTOCTWCHXDX-UHFFFAOYSA-N 221271 US9303015, 45 Nuclear receptor ROR-gamma [258-518,Y502F] 810 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221271&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223159 335960343 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8 387303 Cn1cncc1C(O)(c1ccc(nc1)C(F)(F)F)c1ccc2nc(Cl)c(Oc3ccc(Cl)cc3)c(c2c1)C(F)(F)F InChI=1S/C27H16Cl2F6N4O2/c1-39-13-36-12-21(39)25(40,15-3-9-20(37-11-15)26(30,31)32)14-2-8-19-18(10-14)22(27(33,34)35)23(24(29)38-19)41-17-6-4-16(28)5-7-17/h2-13,40H,1H3 QJWLSDFUZNNSGX-UHFFFAOYSA-N 221272 US9303015, 46 Nuclear receptor ROR-gamma [258-518,Y502F] >6000 US Patent 10.7270/Q29P30H5 aid1802553 US9303015 Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=221272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9294&target=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=221272&enzyme=Nuclear+receptor+ROR-gamma+%5B258-518%2CY502F%5D&column=ki&startPg=0&Increment=50&submit=Search 74223161 335960344 1 STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLFKELFSTETESPVGLSK 3B0W,3KYT,3L0J,4XT9,4YPQ,4ZJR,4ZJW,4ZOM,5APH,5APJ,5APK,5ETH,5G42,5G43,5G44,5G45,5G46,5K38,5K3L,5K3M,5K3N,5K6E,5K74,5UFO,5UFR,5UHI,5W4R,5YP5,5ZA1,6B30,6B31,6B33,6BR2,6BR3,6CVH,6E3E,6ESN,6FGQ,6NAD,6NWT,6Q2W,6R7A,6R7J,6R7K,6SLZ,6VSW,7E3M,7OFI,7OFK,8GXP Nuclear receptor ROR-gamma RORG_HUMAN P51449 Q5SZR9 Q8N5V7 Q8NCY8