BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 948115 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(N2CCC(O)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C23H28FN7O3/c24-20-22(26-15-4-3-8-30(13-15)19(34)14-32)27-21(17-12-25-31-9-2-1-5-18(17)31)28-23(20)29-10-6-16(33)7-11-29/h1-2,5,9,12,15-16,32-33H,3-4,6-8,10-11,13-14H2,(H,26,27,28)/t15-/m1/s1 FLULSAFXRORLGE-OAHLLOKOSA-N 458869 US10759793, Example 22 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458869&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125731 441290133 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948118 OCC1CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C24H30FN7O3/c25-21-23(27-17-4-3-8-31(13-17)20(35)15-34)28-22(18-12-26-32-9-2-1-5-19(18)32)29-24(21)30-10-6-16(14-33)7-11-30/h1-2,5,9,12,16-17,33-34H,3-4,6-8,10-11,13-15H2,(H,27,28,29)/t17-/m1/s1 MHNUSKZAPBFDGM-QGZVFWFLSA-N 458870 US10759793, Example 23 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458870&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587611 441290134 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948121 OCCNc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C20H24FN7O3/c21-17-19(22-6-9-29)25-18(14-10-23-28-8-2-1-5-15(14)28)26-20(17)24-13-4-3-7-27(11-13)16(31)12-30/h1-2,5,8,10,13,29-30H,3-4,6-7,9,11-12H2,(H2,22,24,25,26)/t13-/m1/s1 OLMJDLRMFZPFDM-CYBMUJFWSA-N 458871 US10759793, Example 24 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458871&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125804 441290135 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948124 CN1CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C23H29FN8O2/c1-29-9-11-30(12-10-29)23-20(24)22(26-16-5-4-7-31(14-16)19(34)15-33)27-21(28-23)17-13-25-32-8-3-2-6-18(17)32/h2-3,6,8,13,16,33H,4-5,7,9-12,14-15H2,1H3,(H,26,27,28)/t16-/m1/s1 AOYDAUKHFAZAOW-MRXNPFEDSA-N 458872 US10759793, Example 25 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458872&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125689 441290136 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948127 Cc1c(N[C@@H]2CCCN(C2)C(=O)CO)nc(nc1N1CCOCC1)-c1cnn2ccccc12 InChI=1S/C23H29N7O3/c1-16-21(25-17-5-4-7-29(14-17)20(32)15-31)26-22(27-23(16)28-9-11-33-12-10-28)18-13-24-30-8-3-2-6-19(18)30/h2-3,6,8,13,17,31H,4-5,7,9-12,14-15H2,1H3,(H,25,26,27)/t17-/m1/s1 MGYBGOVGYSINGY-QGZVFWFLSA-N 458873 US10759793, Example 26 Tyrosine-protein kinase JAK3 [795-1124] 30.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458873&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125900 441290137 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948130 COCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1C)-c1cnn2ccccc12 InChI=1S/C22H28N6O4/c1-15-20(24-16-6-5-8-27(13-16)19(30)14-29)25-21(26-22(15)32-11-10-31-2)17-12-23-28-9-4-3-7-18(17)28/h3-4,7,9,12,16,29H,5-6,8,10-11,13-14H2,1-2H3,(H,24,25,26)/t16-/m1/s1 UFWACAZXEBOLDO-MRXNPFEDSA-N 458875 US10759793, Example 27 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458875&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587602 441290139 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948133 CCOC(=O)C1(C)CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C27H34FN7O4/c1-3-39-26(38)27(2)9-13-33(14-10-27)25-22(28)24(30-18-7-6-11-34(16-18)21(37)17-36)31-23(32-25)19-15-29-35-12-5-4-8-20(19)35/h4-5,8,12,15,18,36H,3,6-7,9-11,13-14,16-17H2,1-2H3,(H,30,31,32)/t18-/m1/s1 MHTLRCXLPRAEFN-GOSISDBHSA-N 458876 US10759793, Example 28 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458876&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125745 441290140 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948136 Cc1ccn2ncc(-c3nc(N[C@@H]4CCCN(C4)C(=O)CO)c(F)c(n3)N3CCOCC3)c2c1 InChI=1S/C23H28FN7O3/c1-15-4-6-31-18(11-15)17(12-25-31)21-27-22(20(24)23(28-21)29-7-9-34-10-8-29)26-16-3-2-5-30(13-16)19(33)14-32/h4,6,11-12,16,32H,2-3,5,7-10,13-14H2,1H3,(H,26,27,28)/t16-/m1/s1 VMZQZRVHJMFWFF-MRXNPFEDSA-N 458877 US10759793, Example 29 Tyrosine-protein kinase JAK3 [795-1124] 10.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458877&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125674 441290141 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948139 CCOC(=O)C1CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C27H31FN8O3/c1-2-39-27(38)18-9-14-34(15-10-18)26-23(28)25(31-19-6-5-12-35(17-19)22(37)8-11-29)32-24(33-26)20-16-30-36-13-4-3-7-21(20)36/h3-4,7,13,16,18-19H,2,5-6,8-10,12,14-15,17H2,1H3,(H,31,32,33)/t19-/m1/s1 QESQMBRWXVJRQW-LJQANCHMSA-N 458878 US10759793, Example 30 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458878&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125709 441290142 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948142 OC(=O)C1CCN(CC1)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H27FN8O3/c26-21-23(29-17-4-3-10-33(15-17)20(35)6-9-27)30-22(18-14-28-34-11-2-1-5-19(18)34)31-24(21)32-12-7-16(8-13-32)25(36)37/h1-2,5,11,14,16-17H,3-4,6-8,10,12-13,15H2,(H,36,37)(H,29,30,31)/t17-/m1/s1 CEUUZGACJVNNQR-QGZVFWFLSA-N 458879 US10759793, Example 31 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458879&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587627 441290143 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948145 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(-c2cn[nH]c2)c1F)-c1cnn2ccccc12 InChI=1S/C21H21FN8O2/c22-18-19(13-8-23-24-9-13)27-20(15-10-25-30-7-2-1-5-16(15)30)28-21(18)26-14-4-3-6-29(11-14)17(32)12-31/h1-2,5,7-10,14,31H,3-4,6,11-12H2,(H,23,24)(H,26,27,28)/t14-/m1/s1 IILSYWHBZRJVTF-CQSZACIVSA-N 458880 US10759793, Example 32 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458880&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125725 441290144 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948148 CC(C)(O)Cn1cc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C25H29FN8O3/c1-25(2,37)15-33-12-16(10-27-33)22-21(26)24(29-17-6-5-8-32(13-17)20(36)14-35)31-23(30-22)18-11-28-34-9-4-3-7-19(18)34/h3-4,7,9-12,17,35,37H,5-6,8,13-15H2,1-2H3,(H,29,30,31)/t17-/m1/s1 PPPZKRNWVZENFR-QGZVFWFLSA-N 458881 US10759793, Example 33 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458881&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125657 441290145 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948151 Cc1cc(ccn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C24H24FN7O2/c1-15-11-16(7-8-26-15)22-21(25)24(28-17-5-4-9-31(13-17)20(34)14-33)30-23(29-22)18-12-27-32-10-3-2-6-19(18)32/h2-3,6-8,10-12,17,33H,4-5,9,13-14H2,1H3,(H,28,29,30)/t17-/m1/s1 KWGLHLYWTQSATC-QGZVFWFLSA-N 458882 US10759793, Example 34 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458882&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125855 441290146 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948154 COc1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C24H24FN7O3/c1-35-19-8-7-15(11-26-19)22-21(25)24(28-16-5-4-9-31(13-16)20(34)14-33)30-23(29-22)17-12-27-32-10-3-2-6-18(17)32/h2-3,6-8,10-12,16,33H,4-5,9,13-14H2,1H3,(H,28,29,30)/t16-/m1/s1 JYNIODRMFQRXRR-MRXNPFEDSA-N 458883 US10759793, Example 35 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458883&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125816 441290147 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948157 Cc1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C24H24FN7O2/c1-15-7-8-16(11-26-15)22-21(25)24(28-17-5-4-9-31(13-17)20(34)14-33)30-23(29-22)18-12-27-32-10-3-2-6-19(18)32/h2-3,6-8,10-12,17,33H,4-5,9,13-14H2,1H3,(H,28,29,30)/t17-/m1/s1 ZALLKOLNRWHMDP-QGZVFWFLSA-N 458884 US10759793, Example 36 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458884&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125676 441290148 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948160 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1ccnc(CO)c1)-c1cnn2ccccc12 InChI=1S/C24H24FN7O3/c25-21-22(15-6-7-26-17(10-15)13-33)29-23(18-11-27-32-9-2-1-5-19(18)32)30-24(21)28-16-4-3-8-31(12-16)20(35)14-34/h1-2,5-7,9-11,16,33-34H,3-4,8,12-14H2,(H,28,29,30)/t16-/m1/s1 XXXCCDPUSDWHLL-MRXNPFEDSA-N 458885 US10759793, Example 37 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458885&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125758 441290149 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948163 CCOC(=O)c1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C26H26FN7O4/c1-2-38-26(37)19-9-8-16(12-28-19)23-22(27)25(30-17-6-5-10-33(14-17)21(36)15-35)32-24(31-23)18-13-29-34-11-4-3-7-20(18)34/h3-4,7-9,11-13,17,35H,2,5-6,10,14-15H2,1H3,(H,30,31,32)/t17-/m1/s1 ZGOCSWNTUPRQLQ-QGZVFWFLSA-N 458886 US10759793, Example 38 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458886&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125666 441290150 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948166 COCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H25FN6O4/c1-31-9-10-32-21-18(22)20(24-14-5-4-7-27(12-14)17(30)13-29)25-19(26-21)15-11-23-28-8-3-2-6-16(15)28/h2-3,6,8,11,14,29H,4-5,7,9-10,12-13H2,1H3,(H,24,25,26)/t14-/m1/s1 SDOOZXBGDBTMNH-CQSZACIVSA-N 458887 US10759793, Example 39 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458887&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125844 441290151 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948169 OCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C20H23FN6O4/c21-17-19(23-13-4-3-6-26(11-13)16(30)12-29)24-18(25-20(17)31-9-8-28)14-10-22-27-7-2-1-5-15(14)27/h1-2,5,7,10,13,28-29H,3-4,6,8-9,11-12H2,(H,23,24,25)/t13-/m1/s1 KKKGACSJOWLLJT-CYBMUJFWSA-N 458888 US10759793, Example 40 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458888&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125840 441290152 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948172 OCCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H25FN6O4/c22-18-20(24-14-5-3-7-27(12-14)17(31)13-30)25-19(26-21(18)32-10-4-9-29)15-11-23-28-8-2-1-6-16(15)28/h1-2,6,8,11,14,29-30H,3-5,7,9-10,12-13H2,(H,24,25,26)/t14-/m1/s1 POAJYYPTWJAZBM-CQSZACIVSA-N 458889 US10759793, Example 41 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458889&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125673 441290153 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948175 COc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C19H21FN6O3/c1-29-19-16(20)18(22-12-5-4-7-25(10-12)15(28)11-27)23-17(24-19)13-9-21-26-8-3-2-6-14(13)26/h2-3,6,8-9,12,27H,4-5,7,10-11H2,1H3,(H,22,23,24)/t12-/m1/s1 BOMBGSZZKIZZHV-GFCCVEGCSA-N 458890 US10759793, Example 42 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458890&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125653 441290154 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948178 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(O)c1F)-c1cnn2ccccc12 InChI=1S/C18H19FN6O3/c19-15-17(21-11-4-3-6-24(9-11)14(27)10-26)22-16(23-18(15)28)12-8-20-25-7-2-1-5-13(12)25/h1-2,5,7-8,11,26H,3-4,6,9-10H2,(H2,21,22,23,28)/t11-/m1/s1 NVBQTXSDPUPJRD-LLVKDONJSA-N 458891 US10759793, Example 43 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458891&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137032411 441290155 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948181 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(OC(Cc2ccccc2)C([O-])=O)c1F)-c1cnn2ccccc12 InChI=1S/C27H27FN6O5/c28-23-25(30-18-9-6-11-33(15-18)22(36)16-35)31-24(19-14-29-34-12-5-4-10-20(19)34)32-26(23)39-21(27(37)38)13-17-7-2-1-3-8-17/h1-5,7-8,10,12,14,18,21,35H,6,9,11,13,15-16H2,(H,37,38)(H,30,31,32)/p-1/t18-,21?/m1/s1 STFSWGOEGVDGNW-ITUIMRKVSA-M 458892 US10759793, Example 44 Tyrosine-protein kinase JAK3 [795-1124] 140 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458892&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 154024615 441290156 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948184 CCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C20H23FN6O3/c1-2-30-20-17(21)19(23-13-6-5-8-26(11-13)16(29)12-28)24-18(25-20)14-10-22-27-9-4-3-7-15(14)27/h3-4,7,9-10,13,28H,2,5-6,8,11-12H2,1H3,(H,23,24,25)/t13-/m1/s1 JTJTXNILNQBIOM-CYBMUJFWSA-N 458893 US10759793, Example 45 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458893&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125787 441290157 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948187 CCOC(=O)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H23FN6O4/c1-2-32-21(31)18-17(22)20(24-13-6-5-8-27(11-13)16(30)12-29)26-19(25-18)14-10-23-28-9-4-3-7-15(14)28/h3-4,7,9-10,13,29H,2,5-6,8,11-12H2,1H3,(H,24,25,26)/t13-/m1/s1 VTKIEGXBWOAUCC-CYBMUJFWSA-N 458895 US10759793, Example 46 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458895&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125668 441290159 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948190 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(C#N)c1F)-c1cnn2ccccc12 InChI=1S/C19H18FN7O2/c20-17-14(8-21)24-18(13-9-22-27-7-2-1-5-15(13)27)25-19(17)23-12-4-3-6-26(10-12)16(29)11-28/h1-2,5,7,9,12,28H,3-4,6,10-11H2,(H,23,24,25)/t12-/m1/s1 ULMREEACJUYPBU-GFCCVEGCSA-N 458896 US10759793, Example 47 Tyrosine-protein kinase JAK3 [795-1124] 12.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458896&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125734 441290160 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948193 NC(=O)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C19H20FN7O3/c20-15-16(17(21)30)24-18(12-8-22-27-7-2-1-5-13(12)27)25-19(15)23-11-4-3-6-26(9-11)14(29)10-28/h1-2,5,7-8,11,28H,3-4,6,9-10H2,(H2,21,30)(H,23,24,25)/t11-/m1/s1 RAVDZLATDNOQQX-LLVKDONJSA-N 458897 US10759793, Example 48 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458897&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125658 441290161 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948196 OCC(=O)N1CCC[C@H](C1)Nc1cc(OCC(F)(F)F)nc(n1)-c1cnn2ccccc12 InChI=1S/C20H21F3N6O3/c21-20(22,23)12-32-17-8-16(25-13-4-3-6-28(10-13)18(31)11-30)26-19(27-17)14-9-24-29-7-2-1-5-15(14)29/h1-2,5,7-9,13,30H,3-4,6,10-12H2,(H,25,26,27)/t13-/m1/s1 ZRIXERDDDKMXTF-CYBMUJFWSA-N 458898 US10759793, Example 49 Tyrosine-protein kinase JAK3 [795-1124] 14.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458898&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 155903368 441290162 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948199 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(OCC(F)F)c1F)-c1cnn2ccccc12 InChI=1S/C20H21F3N6O3/c21-15(22)11-32-20-17(23)19(25-12-4-3-6-28(9-12)16(31)10-30)26-18(27-20)13-8-24-29-7-2-1-5-14(13)29/h1-2,5,7-8,12,15,30H,3-4,6,9-11H2,(H,25,26,27)/t12-/m1/s1 YPBDPMATNYYAFH-GFCCVEGCSA-N 458901 US10759793, Example 50 Tyrosine-protein kinase JAK3 [795-1124] 9.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458901&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125688 441290165 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948202 CC(C)Oc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H25FN6O3/c1-13(2)31-21-18(22)20(24-14-6-5-8-27(11-14)17(30)12-29)25-19(26-21)15-10-23-28-9-4-3-7-16(15)28/h3-4,7,9-10,13-14,29H,5-6,8,11-12H2,1-2H3,(H,24,25,26)/t14-/m1/s1 VHIOONXGLXMHFR-CQSZACIVSA-N 458902 US10759793, Example 51 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458902&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125679 441290166 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948205 OCC(=O)N1CCC[C@H](C1)Oc1nc(nc(N2CCOCC2)c1F)-c1cnn2ccccc12 InChI=1S/C22H25FN6O4/c23-19-21(27-8-10-32-11-9-27)25-20(16-12-24-29-7-2-1-5-17(16)29)26-22(19)33-15-4-3-6-28(13-15)18(31)14-30/h1-2,5,7,12,15,30H,3-4,6,8-11,13-14H2/t15-/m1/s1 HSXKXANEZOHANU-OAHLLOKOSA-N 458905 US10759793, Example 52 Tyrosine-protein kinase JAK3 [795-1124] 11.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458905&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125662 441290169 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948208 Fc1c(O[C@@H]2CCCN(C2)C(=O)CC#N)nc(nc1N1CCOCC1)-c1cnn2ccccc12 InChI=1S/C23H24FN7O3/c24-20-22(29-10-12-33-13-11-29)27-21(17-14-26-31-9-2-1-5-18(17)31)28-23(20)34-16-4-3-8-30(15-16)19(32)6-7-25/h1-2,5,9,14,16H,3-4,6,8,10-13,15H2/t16-/m1/s1 BOTXIWILRGOPLU-MRXNPFEDSA-N 458906 US10759793, Example 53 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458906&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125726 441290170 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948211 OCCOc1nc(nc(N[C@@H]2CCCN(C2)c2cnc(cn2)C#N)c1F)-c1cnn2ccccc12 InChI=1S/C23H22FN9O2/c24-20-22(29-15-4-3-6-32(14-15)19-13-26-16(10-25)11-27-19)30-21(31-23(20)35-9-8-34)17-12-28-33-7-2-1-5-18(17)33/h1-2,5,7,11-13,15,34H,3-4,6,8-9,14H2,(H,29,30,31)/t15-/m1/s1 KNWWIXHOFCTMFC-OAHLLOKOSA-N 458908 US10759793, Example 54 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458908&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125671 441290172 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948214 COc1nc(nc(N[C@@H]2CCCN(C2)c2cnc(CO)cn2)c1F)-c1cnn2ccccc12 InChI=1S/C22H23FN8O2/c1-33-22-19(23)21(28-20(29-22)16-10-26-31-8-3-2-6-17(16)31)27-14-5-4-7-30(12-14)18-11-24-15(13-32)9-25-18/h2-3,6,8-11,14,32H,4-5,7,12-13H2,1H3,(H,27,28,29)/t14-/m1/s1 HEEASSUKROWAOL-CQSZACIVSA-N 458909 US10759793, Example 55 Tyrosine-protein kinase JAK3 [795-1124] 33.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458909&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125777 441290173 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948217 COc1nc(nc(N[C@@H]2CCCN(C2)c2cnc(cn2)C#N)c1F)-c1cnn2ccccc12 InChI=1S/C22H20FN9O/c1-33-22-19(23)21(29-20(30-22)16-11-27-32-8-3-2-6-17(16)32)28-14-5-4-7-31(13-14)18-12-25-15(9-24)10-26-18/h2-3,6,8,10-12,14H,4-5,7,13H2,1H3,(H,28,29,30)/t14-/m1/s1 HVJSKQDKDWXSHU-CQSZACIVSA-N 458910 US10759793, Example 56 Tyrosine-protein kinase JAK3 [795-1124] 8.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458910&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125700 441290174 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948220 OCCOc1nc(nc(N[C@@H]2CCCN(C2)c2ncc(cn2)C#N)c1F)-c1cnn2ccccc12 InChI=1S/C23H22FN9O2/c24-19-21(29-16-4-3-6-32(14-16)23-26-11-15(10-25)12-27-23)30-20(31-22(19)35-9-8-34)17-13-28-33-7-2-1-5-18(17)33/h1-2,5,7,11-13,16,34H,3-4,6,8-9,14H2,(H,29,30,31)/t16-/m1/s1 WJKJZOLCVIWRAM-MRXNPFEDSA-N 458911 US10759793, Example 57 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458911&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125819 441290175 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948223 COC[C@H](C)Oc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C22H27FN6O4/c1-14(13-32-2)33-22-19(23)21(25-15-6-5-8-28(11-15)18(31)12-30)26-20(27-22)16-10-24-29-9-4-3-7-17(16)29/h3-4,7,9-10,14-15,30H,5-6,8,11-13H2,1-2H3,(H,25,26,27)/t14-,15+/m0/s1 WKPAFBZECCXWJB-LSDHHAIUSA-N 458912 US10759793, Example 58 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458912&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125795 441290176 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948226 C[C@@H](CO)Oc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H25FN6O4/c1-13(11-29)32-21-18(22)20(24-14-5-4-7-27(10-14)17(31)12-30)25-19(26-21)15-9-23-28-8-3-2-6-16(15)28/h2-3,6,8-9,13-14,29-30H,4-5,7,10-12H2,1H3,(H,24,25,26)/t13-,14+/m0/s1 SWVPQIQUKNKZQC-UONOGXRCSA-N 458913 US10759793, Example 59 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458913&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125677 441290177 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948229 COC[C@@H](C)Oc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C22H27FN6O4/c1-14(13-32-2)33-22-19(23)21(25-15-6-5-8-28(11-15)18(31)12-30)26-20(27-22)16-10-24-29-9-4-3-7-17(16)29/h3-4,7,9-10,14-15,30H,5-6,8,11-13H2,1-2H3,(H,25,26,27)/t14-,15-/m1/s1 WKPAFBZECCXWJB-HUUCEWRRSA-N 458914 US10759793, Example 60 Tyrosine-protein kinase JAK3 [795-1124] 16.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458914&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125715 441290178 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948232 C[C@H](CO)Oc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H25FN6O4/c1-13(11-29)32-21-18(22)20(24-14-5-4-7-27(10-14)17(31)12-30)25-19(26-21)15-9-23-28-8-3-2-6-16(15)28/h2-3,6,8-9,13-14,29-30H,4-5,7,10-12H2,1H3,(H,24,25,26)/t13-,14-/m1/s1 SWVPQIQUKNKZQC-ZIAGYGMSSA-N 458915 US10759793, Example 61 Tyrosine-protein kinase JAK3 [795-1124] 8.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458915&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125697 441290179 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948235 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1cccnc1)-c1cnn2ccccc12 InChI=1S/C23H22FN7O2/c24-20-21(15-5-3-8-25-11-15)28-22(17-12-26-31-10-2-1-7-18(17)31)29-23(20)27-16-6-4-9-30(13-16)19(33)14-32/h1-3,5,7-8,10-12,16,32H,4,6,9,13-14H2,(H,27,28,29)/t16-/m1/s1 MZLPBSXDCPIJKW-MRXNPFEDSA-N 458916 US10759793, Example 62 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458916&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125905 441290180 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948238 COc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C19H20FN5O4/c1-28-18-16(20)19(29-12-5-4-7-24(10-12)15(27)11-26)23-17(22-18)13-9-21-25-8-3-2-6-14(13)25/h2-3,6,8-9,12,26H,4-5,7,10-11H2,1H3/t12-/m1/s1 YADYADRVBYWWSL-GFCCVEGCSA-N 458917 US10759793, Example 63 Tyrosine-protein kinase JAK3 [795-1124] 9.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458917&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125718 441290181 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948241 COc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C20H19FN6O3/c1-29-19-17(21)20(30-13-5-4-9-26(12-13)16(28)7-8-22)25-18(24-19)14-11-23-27-10-3-2-6-15(14)27/h2-3,6,10-11,13H,4-5,7,9,12H2,1H3/t13-/m1/s1 UOLVNPIMESKKOL-CYBMUJFWSA-N 458918 US10759793, Example 64 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458918&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125868 441290182 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948244 OCCOc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C20H22FN5O5/c21-17-19(30-9-8-27)23-18(14-10-22-26-7-2-1-5-15(14)26)24-20(17)31-13-4-3-6-25(11-13)16(29)12-28/h1-2,5,7,10,13,27-28H,3-4,6,8-9,11-12H2/t13-/m1/s1 UUWRRBUQXPSAFN-CYBMUJFWSA-N 458919 US10759793, Example 65 Tyrosine-protein kinase JAK3 [795-1124] 9.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458919&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125714 441290183 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948247 OCCOc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C21H21FN6O4/c22-18-20(31-11-10-29)25-19(15-12-24-28-9-2-1-5-16(15)28)26-21(18)32-14-4-3-8-27(13-14)17(30)6-7-23/h1-2,5,9,12,14,29H,3-4,6,8,10-11,13H2/t14-/m1/s1 ZHSRZLKJPPIXFX-CQSZACIVSA-N 458920 US10759793, Example 66 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458920&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125661 441290184 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948250 CN1CCN(CC1)c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C23H28FN7O3/c1-28-9-11-29(12-10-28)22-20(24)23(34-16-5-4-7-30(14-16)19(33)15-32)27-21(26-22)17-13-25-31-8-3-2-6-18(17)31/h2-3,6,8,13,16,32H,4-5,7,9-12,14-15H2,1H3/t16-/m1/s1 PTQXPAOWHCAGEC-MRXNPFEDSA-N 458921 US10759793, Example 67 Tyrosine-protein kinase JAK3 [795-1124] 23.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458921&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125746 441290185 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948253 CN1CCN(CC1)c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C24H27FN8O2/c1-30-11-13-31(14-12-30)23-21(25)24(35-17-5-4-9-32(16-17)20(34)7-8-26)29-22(28-23)18-15-27-33-10-3-2-6-19(18)33/h2-3,6,10,15,17H,4-5,7,9,11-14,16H2,1H3/t17-/m1/s1 RXBPSCJUMUCIDA-QGZVFWFLSA-N 458922 US10759793, Example 68 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458922&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125721 441290186 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948256 OCCNc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C20H23FN6O4/c21-17-19(22-6-9-28)24-18(14-10-23-27-8-2-1-5-15(14)27)25-20(17)31-13-4-3-7-26(11-13)16(30)12-29/h1-2,5,8,10,13,28-29H,3-4,6-7,9,11-12H2,(H,22,24,25)/t13-/m1/s1 OXSMPLGSBZKFQF-CYBMUJFWSA-N 458923 US10759793, Example 69 Tyrosine-protein kinase JAK3 [795-1124] 11.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458923&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125665 441290187 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948259 OCCNc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C21H22FN7O3/c22-18-20(24-8-11-30)26-19(15-12-25-29-10-2-1-5-16(15)29)27-21(18)32-14-4-3-9-28(13-14)17(31)6-7-23/h1-2,5,10,12,14,30H,3-4,6,8-9,11,13H2,(H,24,26,27)/t14-/m1/s1 LTGKXXQYJLCSKU-CQSZACIVSA-N 458924 US10759793, Example 70 Tyrosine-protein kinase JAK3 [795-1124] 8.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458924&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125728 441290188 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948262 Cc1cc(ccn1)-c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C24H23FN6O3/c1-15-11-16(7-8-26-15)22-21(25)24(34-17-5-4-9-30(13-17)20(33)14-32)29-23(28-22)18-12-27-31-10-3-2-6-19(18)31/h2-3,6-8,10-12,17,32H,4-5,9,13-14H2,1H3/t17-/m1/s1 QKJPUODYIWDHBP-QGZVFWFLSA-N 458925 US10759793, Example 71 Tyrosine-protein kinase JAK3 [795-1124] 26.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458925&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125750 441290189 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948265 Cc1cc(ccn1)-c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H22FN7O2/c1-16-13-17(8-10-28-16)23-22(26)25(35-18-5-4-11-32(15-18)21(34)7-9-27)31-24(30-23)19-14-29-33-12-3-2-6-20(19)33/h2-3,6,8,10,12-14,18H,4-5,7,11,15H2,1H3/t18-/m1/s1 RMXZXZKQSBPGTH-GOSISDBHSA-N 458926 US10759793, Example 72 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458926&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125806 441290190 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948268 OCc1cc(ccn1)-c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H22FN7O3/c26-22-23(16-7-9-28-17(12-16)15-34)30-24(19-13-29-33-11-2-1-5-20(19)33)31-25(22)36-18-4-3-10-32(14-18)21(35)6-8-27/h1-2,5,7,9,11-13,18,34H,3-4,6,10,14-15H2/t18-/m1/s1 MQHSJSWUTCMWEF-GOSISDBHSA-N 458927 US10759793, Example 73 Tyrosine-protein kinase JAK3 [795-1124] 27.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458927&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125683 441290191 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948271 OCC(=O)N1CCC[C@H](C1)Oc1nc(nc(c1F)-c1ccnc(CO)c1)-c1cnn2ccccc12 InChI=1S/C24H23FN6O4/c25-21-22(15-6-7-26-16(10-15)13-32)28-23(18-11-27-31-9-2-1-5-19(18)31)29-24(21)35-17-4-3-8-30(12-17)20(34)14-33/h1-2,5-7,9-11,17,32-33H,3-4,8,12-14H2/t17-/m1/s1 YEGRIGPWQYSUFX-QGZVFWFLSA-N 458929 US10759793, Example 74 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458929&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125692 441290193 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948274 OCC(=O)N1CCC[C@H](C1)Oc1nc(nc(N2CCC(O)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C23H27FN6O4/c24-20-22(28-10-6-15(32)7-11-28)26-21(17-12-25-30-9-2-1-5-18(17)30)27-23(20)34-16-4-3-8-29(13-16)19(33)14-31/h1-2,5,9,12,15-16,31-32H,3-4,6-8,10-11,13-14H2/t16-/m1/s1 NCTRFRQNWKWDDG-MRXNPFEDSA-N 458930 US10759793, Example 75 Tyrosine-protein kinase JAK3 [795-1124] 26.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458930&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125682 441290194 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948277 OC1CCN(CC1)c1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C24H26FN7O3/c25-21-23(30-12-7-16(33)8-13-30)28-22(18-14-27-32-11-2-1-5-19(18)32)29-24(21)35-17-4-3-10-31(15-17)20(34)6-9-26/h1-2,5,11,14,16-17,33H,3-4,6-8,10,12-13,15H2/t17-/m1/s1 JIZQUZNLIFLXCN-QGZVFWFLSA-N 458931 US10759793, Example 76 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458931&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125920 441290195 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948280 CN([C@@H]1CCCN(C1)C(=O)CO)c1nc(nc(-c2ccnc(C)c2)c1F)-c1cnn2ccccc12 InChI=1S/C25H26FN7O2/c1-16-12-17(8-9-27-16)23-22(26)25(31(2)18-6-5-10-32(14-18)21(35)15-34)30-24(29-23)19-13-28-33-11-4-3-7-20(19)33/h3-4,7-9,11-13,18,34H,5-6,10,14-15H2,1-2H3/t18-/m1/s1 SOPZZEGVHYHJQG-GOSISDBHSA-N 458932 US10759793, Example 77 Tyrosine-protein kinase JAK3 [795-1124] 23.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458932&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125701 441290196 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948283 OCc1cc(ccn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H23FN8O2/c26-22-23(16-7-9-28-18(12-16)15-35)31-24(19-13-29-34-11-2-1-5-20(19)34)32-25(22)30-17-4-3-10-33(14-17)21(36)6-8-27/h1-2,5,7,9,11-13,17,35H,3-4,6,10,14-15H2,(H,30,31,32)/t17-/m1/s1 LHVXQTSZFNKIKA-QGZVFWFLSA-N 458933 US10759793, Example 78 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458933&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125778 441290197 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948286 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1ccc(nc1)C(O)=O)-c1cnn2ccccc12 InChI=1S/C24H22FN7O4/c25-20-21(14-6-7-17(24(35)36)26-10-14)29-22(16-11-27-32-9-2-1-5-18(16)32)30-23(20)28-15-4-3-8-31(12-15)19(34)13-33/h1-2,5-7,9-11,15,33H,3-4,8,12-13H2,(H,35,36)(H,28,29,30)/t15-/m1/s1 TWIMCMZUXXEZMN-OAHLLOKOSA-N 458934 US10759793, Example 79 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458934&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125740 441290198 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948289 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1ccncc1)-c1cnn2ccccc12 InChI=1S/C23H22FN7O2/c24-20-21(15-6-8-25-9-7-15)28-22(17-12-26-31-11-2-1-5-18(17)31)29-23(20)27-16-4-3-10-30(13-16)19(33)14-32/h1-2,5-9,11-12,16,32H,3-4,10,13-14H2,(H,27,28,29)/t16-/m1/s1 AIEHEAYBKXQCBV-MRXNPFEDSA-N 458935 US10759793, Example 80 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458935&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125898 441290199 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948292 CN(C)c1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C25H27FN8O2/c1-32(2)20-9-8-16(12-27-20)23-22(26)25(29-17-6-5-10-33(14-17)21(36)15-35)31-24(30-23)18-13-28-34-11-4-3-7-19(18)34/h3-4,7-9,11-13,17,35H,5-6,10,14-15H2,1-2H3,(H,29,30,31)/t17-/m1/s1 SMBOJHIPMZSPKN-QGZVFWFLSA-N 458936 US10759793, Example 81 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458936&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125742 441290200 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948295 Cc1ncc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C23H23FN8O2/c1-14-25-9-15(10-26-14)21-20(24)23(28-16-5-4-7-31(12-16)19(34)13-33)30-22(29-21)17-11-27-32-8-3-2-6-18(17)32/h2-3,6,8-11,16,33H,4-5,7,12-13H2,1H3,(H,28,29,30)/t16-/m1/s1 LFUQNPCCBGXDHH-MRXNPFEDSA-N 458937 US10759793, Example 82 Tyrosine-protein kinase JAK3 [795-1124] 8.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458937&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125759 441290201 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948298 CCOCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C22H27FN6O4/c1-2-32-10-11-33-22-19(23)21(25-15-6-5-8-28(13-15)18(31)14-30)26-20(27-22)16-12-24-29-9-4-3-7-17(16)29/h3-4,7,9,12,15,30H,2,5-6,8,10-11,13-14H2,1H3,(H,25,26,27)/t15-/m1/s1 LJOCKOTYPPAJJM-OAHLLOKOSA-N 458938 US10759793, Example 83 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458938&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125857 441290202 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948301 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1ccc(CO)nc1)-c1cnn2ccccc12 InChI=1S/C24H24FN7O3/c25-21-22(15-6-7-17(13-33)26-10-15)29-23(18-11-27-32-9-2-1-5-19(18)32)30-24(21)28-16-4-3-8-31(12-16)20(35)14-34/h1-2,5-7,9-11,16,33-34H,3-4,8,12-14H2,(H,28,29,30)/t16-/m1/s1 VMLDZHVMOAJUBL-MRXNPFEDSA-N 458939 US10759793, Example 84 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458939&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125780 441290203 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948304 OCc1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H23FN8O2/c26-22-23(16-6-7-18(15-35)28-12-16)31-24(19-13-29-34-11-2-1-5-20(19)34)32-25(22)30-17-4-3-10-33(14-17)21(36)8-9-27/h1-2,5-7,11-13,17,35H,3-4,8,10,14-15H2,(H,30,31,32)/t17-/m1/s1 GDSNNUIALVSVIV-QGZVFWFLSA-N 458940 US10759793, Example 85 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458940&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125793 441290204 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948307 Cc1cc(cc(C)n1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C25H26FN7O2/c1-15-10-17(11-16(2)28-15)23-22(26)25(29-18-6-5-8-32(13-18)21(35)14-34)31-24(30-23)19-12-27-33-9-4-3-7-20(19)33/h3-4,7,9-12,18,34H,5-6,8,13-14H2,1-2H3,(H,29,30,31)/t18-/m1/s1 SXNCHAUFGOKGOA-GOSISDBHSA-N 458942 US10759793, Example 86 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458942&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125723 441290206 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948310 Cc1cc(cc(C)n1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C26H25FN8O/c1-16-12-18(13-17(2)30-16)24-23(27)26(31-19-6-5-10-34(15-19)22(36)8-9-28)33-25(32-24)20-14-29-35-11-4-3-7-21(20)35/h3-4,7,11-14,19H,5-6,8,10,15H2,1-2H3,(H,31,32,33)/t19-/m1/s1 XYRZUHIFKZSFBW-LJQANCHMSA-N 458943 US10759793, Example 87 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458943&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125918 441290207 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948313 OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1cncc(CO)c1)-c1cnn2ccccc12 InChI=1S/C24H24FN7O3/c25-21-22(16-8-15(13-33)9-26-10-16)29-23(18-11-27-32-7-2-1-5-19(18)32)30-24(21)28-17-4-3-6-31(12-17)20(35)14-34/h1-2,5,7-11,17,33-34H,3-4,6,12-14H2,(H,28,29,30)/t17-/m1/s1 FKPQARLDMMENON-QGZVFWFLSA-N 458944 US10759793, Example 88 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458944&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125755 441290208 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948316 OCc1cncc(c1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H23FN8O2/c26-22-23(17-10-16(15-35)11-28-12-17)31-24(19-13-29-34-9-2-1-5-20(19)34)32-25(22)30-18-4-3-8-33(14-18)21(36)6-7-27/h1-2,5,9-13,18,35H,3-4,6,8,14-15H2,(H,30,31,32)/t18-/m1/s1 BFPSWQYNXOZVKL-GOSISDBHSA-N 458945 US10759793, Example 89 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458945&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125756 441290209 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948319 C[C@H](O)COc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C21H24FN5O5/c1-13(29)12-31-20-18(22)21(32-14-5-4-7-26(10-14)17(30)11-28)25-19(24-20)15-9-23-27-8-3-2-6-16(15)27/h2-3,6,8-9,13-14,28-29H,4-5,7,10-12H2,1H3/t13-,14+/m0/s1 LEFVLNUJZMIIOE-UONOGXRCSA-N 458946 US10759793, Example 90 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458946&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125766 441290210 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948322 COC[C@@H](C)Oc1nc(nc(N[C@@H]2CCCN(C2)c2cnc(cn2)C#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H26FN9O2/c1-16(15-36-2)37-25-22(26)24(32-23(33-25)19-12-30-35-9-4-3-7-20(19)35)31-17-6-5-8-34(14-17)21-13-28-18(10-27)11-29-21/h3-4,7,9,11-13,16-17H,5-6,8,14-15H2,1-2H3,(H,31,32,33)/t16-,17-/m1/s1 PQSUUSWEYUCMDK-IAGOWNOFSA-N 458947 US10759793, Example 91 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458947&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125764 441290211 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948325 CC(C)OC(=O)c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1F)-c1cnn2ccccc12 InChI=1S/C22H25FN6O4/c1-13(2)33-22(32)19-18(23)21(25-14-6-5-8-28(11-14)17(31)12-30)27-20(26-19)15-10-24-29-9-4-3-7-16(15)29/h3-4,7,9-10,13-14,30H,5-6,8,11-12H2,1-2H3,(H,25,26,27)/t14-/m1/s1 CSGMUUVBJKKXAZ-CQSZACIVSA-N 458948 US10759793, Example 92 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458948&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587603 441290212 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948328 COc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CO)c1C)-c1cnn2ccccc12 InChI=1S/C20H24N6O3/c1-13-18(22-14-6-5-8-25(11-14)17(28)12-27)23-19(24-20(13)29-2)15-10-21-26-9-4-3-7-16(15)26/h3-4,7,9-10,14,27H,5-6,8,11-12H2,1-2H3,(H,22,23,24)/t14-/m1/s1 ISTLRPKMYXXZNH-CQSZACIVSA-N 458949 US10759793, Example 93 Tyrosine-protein kinase JAK3 [795-1124] 6.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458949&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125675 441290213 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948331 COc1cc(N[C@@H]2CCCN(C2)C(=O)CO)nc(n1)-c1cnn2ccccc12 InChI=1S/C19H22N6O3/c1-28-17-9-16(21-13-5-4-7-24(11-13)18(27)12-26)22-19(23-17)14-10-20-25-8-3-2-6-15(14)25/h2-3,6,8-10,13,26H,4-5,7,11-12H2,1H3,(H,21,22,23)/t13-/m1/s1 ASMOEFBUXGQJGQ-CYBMUJFWSA-N 458950 US10759793, Example 94 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458950&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125659 441290214 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948334 COc1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C20H21N7O2/c1-29-18-11-17(23-14-5-4-9-26(13-14)19(28)7-8-21)24-20(25-18)15-12-22-27-10-3-2-6-16(15)27/h2-3,6,10-12,14H,4-5,7,9,13H2,1H3,(H,23,24,25)/t14-/m1/s1 OZBFFRFAFCUAQC-CQSZACIVSA-N 458951 US10759793, Example 95 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458951&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125760 441290215 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948337 COCCOc1cc(N[C@@H]2CCCN(C2)C(=O)CO)nc(n1)-c1cnn2ccccc12 InChI=1S/C21H26N6O4/c1-30-9-10-31-19-11-18(23-15-5-4-7-26(13-15)20(29)14-28)24-21(25-19)16-12-22-27-8-3-2-6-17(16)27/h2-3,6,8,11-12,15,28H,4-5,7,9-10,13-14H2,1H3,(H,23,24,25)/t15-/m1/s1 HVHZSWGNZRRBES-OAHLLOKOSA-N 458952 US10759793, Example 96 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458952&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125917 441290216 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948340 COCCOc1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C22H25N7O3/c1-31-11-12-32-20-13-19(25-16-5-4-9-28(15-16)21(30)7-8-23)26-22(27-20)17-14-24-29-10-3-2-6-18(17)29/h2-3,6,10,13-14,16H,4-5,7,9,11-12,15H2,1H3,(H,25,26,27)/t16-/m1/s1 GOUWLZUXEZOFCF-MRXNPFEDSA-N 458953 US10759793, Example 97 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458953&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125915 441290217 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948343 COc1cc(ccn1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CO)nc(n1)-c1cnn2ccccc12 InChI=1S/C24H25N7O3/c1-34-22-11-16(7-8-25-22)19-12-21(27-17-5-4-9-30(14-17)23(33)15-32)29-24(28-19)18-13-26-31-10-3-2-6-20(18)31/h2-3,6-8,10-13,17,32H,4-5,9,14-15H2,1H3,(H,27,28,29)/t17-/m1/s1 CCAIYUNAWUFZMN-QGZVFWFLSA-N 458954 US10759793, Example 98 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458954&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125822 441290218 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948346 Cc1ccc(cn1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CO)nc(n1)-c1cnn2ccccc12 InChI=1S/C24H25N7O2/c1-16-7-8-17(12-25-16)20-11-22(27-18-5-4-9-30(14-18)23(33)15-32)29-24(28-20)19-13-26-31-10-3-2-6-21(19)31/h2-3,6-8,10-13,18,32H,4-5,9,14-15H2,1H3,(H,27,28,29)/t18-/m1/s1 TYOIGFPYJYCDNW-GOSISDBHSA-N 458955 US10759793, Example 99 Tyrosine-protein kinase JAK3 [795-1124] 7.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458955&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125670 441290219 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948349 Cc1ccc(cn1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C25H24N8O/c1-17-7-8-18(14-27-17)21-13-23(29-19-5-4-11-32(16-19)24(34)9-10-26)31-25(30-21)20-15-28-33-12-3-2-6-22(20)33/h2-3,6-8,12-15,19H,4-5,9,11,16H2,1H3,(H,29,30,31)/t19-/m1/s1 UXHXBHYWVKTLHE-LJQANCHMSA-N 458956 US10759793, Example 100 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458956&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125922 441290220 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948352 Cc1cc(cc(C)n1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CO)nc(n1)-c1cnn2ccccc12 InChI=1S/C25H27N7O2/c1-16-10-18(11-17(2)27-16)21-12-23(28-19-6-5-8-31(14-19)24(34)15-33)30-25(29-21)20-13-26-32-9-4-3-7-22(20)32/h3-4,7,9-13,19,33H,5-6,8,14-15H2,1-2H3,(H,28,29,30)/t19-/m1/s1 SWGBPOVUOLFHDX-LJQANCHMSA-N 458957 US10759793, Example 101 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458957&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125953 441290221 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948355 Cc1cc(cc(C)n1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C26H26N8O/c1-17-12-19(13-18(2)29-17)22-14-24(30-20-6-5-10-33(16-20)25(35)8-9-27)32-26(31-22)21-15-28-34-11-4-3-7-23(21)34/h3-4,7,11-15,20H,5-6,8,10,16H2,1-2H3,(H,30,31,32)/t20-/m1/s1 LXSURCWDPYJUIB-HXUWFJFHSA-N 458958 US10759793, Example 102 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458958&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125789 441290222 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948358 OCCOc1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C21H23N7O3/c22-7-6-20(30)27-8-3-4-15(14-27)24-18-12-19(31-11-10-29)26-21(25-18)16-13-23-28-9-2-1-5-17(16)28/h1-2,5,9,12-13,15,29H,3-4,6,8,10-11,14H2,(H,24,25,26)/t15-/m1/s1 XGOLQHJBQMSTDQ-OAHLLOKOSA-N 458959 US10759793, Example 103 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458959&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125660 441290223 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948361 OCCOc1cc(N[C@@H]2CCCN(C2)c2cnc(cn2)C#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C23H23N9O2/c24-11-17-12-26-21(14-25-17)31-6-3-4-16(15-31)28-20-10-22(34-9-8-33)30-23(29-20)18-13-27-32-7-2-1-5-19(18)32/h1-2,5,7,10,12-14,16,33H,3-4,6,8-9,15H2,(H,28,29,30)/t16-/m1/s1 QOIRMJFSOQSKOW-MRXNPFEDSA-N 458960 US10759793, Example 104 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458960&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125876 441290224 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948364 OCC(=O)N1CCC[C@H](C1)Nc1cc(nc(n1)-c1cnn2ccccc12)-c1cncc(O)c1 InChI=1S/C23H23N7O3/c31-14-22(33)29-6-3-4-16(13-29)26-21-9-19(15-8-17(32)11-24-10-15)27-23(28-21)18-12-25-30-7-2-1-5-20(18)30/h1-2,5,7-12,16,31-32H,3-4,6,13-14H2,(H,26,27,28)/t16-/m1/s1 MEWIVURQWVFVFV-MRXNPFEDSA-N 458961 US10759793, Example 105 Tyrosine-protein kinase JAK3 [795-1124] 5.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458961&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125669 441290225 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948367 Oc1cncc(c1)-c1cc(N[C@@H]2CCCN(C2)C(=O)CC#N)nc(n1)-c1cnn2ccccc12 InChI=1S/C24H22N8O2/c25-7-6-23(34)31-8-3-4-17(15-31)28-22-11-20(16-10-18(33)13-26-12-16)29-24(30-22)19-14-27-32-9-2-1-5-21(19)32/h1-2,5,9-14,17,33H,3-4,6,8,15H2,(H,28,29,30)/t17-/m1/s1 DSSCECJYEQOURZ-QGZVFWFLSA-N 458962 US10759793, Example 106 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458962&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125705 441290226 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948052 OC1CCN(CC1)c1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C24H28FN7O/c25-21-23(28-17-6-4-16(5-7-17)8-11-26)29-22(19-15-27-32-12-2-1-3-20(19)32)30-24(21)31-13-9-18(33)10-14-31/h1-3,12,15-18,33H,4-10,13-14H2,(H,28,29,30)/t16-,17- WBCARRPOSROUOW-QAQDUYKDSA-N 458848 US10759793, Example 1 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458848&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125854 441290112 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948055 NC1CCN(CC1)c1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C24H29FN8/c25-21-23(29-18-6-4-16(5-7-18)8-11-26)30-22(19-15-28-33-12-2-1-3-20(19)33)31-24(21)32-13-9-17(27)10-14-32/h1-3,12,15-18H,4-10,13-14,27H2,(H,29,30,31)/t16-,18- RQSSDOFREINTLE-SAABIXHNSA-N 458849 US10759793, Example 2 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458849&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125959 441290113 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948058 Fc1c(N[C@H]2CC[C@H](CC#N)CC2)nc(nc1N1CCNCC1)-c1cnn2ccccc12 InChI=1S/C23H27FN8/c24-20-22(28-17-6-4-16(5-7-17)8-9-25)29-21(30-23(20)31-13-10-26-11-14-31)18-15-27-32-12-2-1-3-19(18)32/h1-3,12,15-17,26H,4-8,10-11,13-14H2,(H,28,29,30)/t16-,17- DEUXCTNBOHHQJF-QAQDUYKDSA-N 458850 US10759793, Example 3 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458850&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125948 441290114 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948061 CN(C)C1CCN(CC1)c1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C26H33FN8/c1-33(2)20-11-15-34(16-12-20)26-23(27)25(30-19-8-6-18(7-9-19)10-13-28)31-24(32-26)21-17-29-35-14-4-3-5-22(21)35/h3-5,14,17-20H,6-12,15-16H2,1-2H3,(H,30,31,32)/t18-,19- UYMXLYWOTSPSPU-WGSAOQKQSA-N 458851 US10759793, Example 4 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458851&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125891 441290115 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948064 OCCOc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C21H23FN6O2/c22-18-20(25-15-6-4-14(5-7-15)8-9-23)26-19(27-21(18)30-12-11-29)16-13-24-28-10-2-1-3-17(16)28/h1-3,10,13-15,29H,4-8,11-12H2,(H,25,26,27)/t14-,15- OHTOUOSDZHYYPD-SHTZXODSSA-N 458852 US10759793, Example 5 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458852&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125958 441290116 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948067 OC[C@H](O)COc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C22H25FN6O3/c23-19-21(26-15-6-4-14(5-7-15)8-9-24)27-20(28-22(19)32-13-16(31)12-30)17-11-25-29-10-2-1-3-18(17)29/h1-3,10-11,14-16,30-31H,4-8,12-13H2,(H,26,27,28)/t14-,15-,16-/m0/s1 NRQQXDCKITUCNW-JYJNAYRXSA-N 458853 US10759793, Example 6 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458853&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125859 441290117 C02773 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948070 OC[C@@H](O)COc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C22H25FN6O3/c23-19-21(26-15-6-4-14(5-7-15)8-9-24)27-20(28-22(19)32-13-16(31)12-30)17-11-25-29-10-2-1-3-18(17)29/h1-3,10-11,14-16,30-31H,4-8,12-13H2,(H,26,27,28)/t14-,15-,16-/m1/s1 NRQQXDCKITUCNW-BZUAXINKSA-N 458854 US10759793, Example 7 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458854&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587630 441290118 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948073 OCCNc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C21H24FN7O/c22-18-20(24-10-12-30)27-19(16-13-25-29-11-2-1-3-17(16)29)28-21(18)26-15-6-4-14(5-7-15)8-9-23/h1-3,11,13-15,30H,4-8,10,12H2,(H2,24,26,27,28)/t14-,15- UDSFFMBHXWNXOF-SHTZXODSSA-N 458855 US10759793, Example 8 Tyrosine-protein kinase JAK3 [795-1124] 10.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458855&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125897 441290119 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948076 CN(C)CCOc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C23H28FN7O/c1-30(2)13-14-32-23-20(24)22(27-17-8-6-16(7-9-17)10-11-25)28-21(29-23)18-15-26-31-12-4-3-5-19(18)31/h3-5,12,15-17H,6-10,13-14H2,1-2H3,(H,27,28,29)/t16-,17- OJBQUQMIXCARFX-QAQDUYKDSA-N 458856 US10759793, Example 9 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458856&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125825 441290120 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948079 CN(C)CCOc1nc(nc(N[C@@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 InChI=1S/C23H28FN7O/c1-30(2)13-14-32-23-20(24)22(27-17-8-6-16(7-9-17)10-11-25)28-21(29-23)18-15-26-31-12-4-3-5-19(18)31/h3-5,12,15-17H,6-10,13-14H2,1-2H3,(H,27,28,29)/t16-,17+ OJBQUQMIXCARFX-CALCHBBNSA-N 458857 US10759793, Example 10 Tyrosine-protein kinase JAK3 [795-1124] 0.700 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458857&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125825 441290121 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948082 C[C@H](Nc1nc(nc(N2CCC(N)CC2)c1F)-c1cnn2ccccc12)c1ccc(F)cn1 InChI=1S/C23H24F2N8/c1-14(18-6-5-15(24)12-27-18)29-22-20(25)23(32-10-7-16(26)8-11-32)31-21(30-22)17-13-28-33-9-3-2-4-19(17)33/h2-6,9,12-14,16H,7-8,10-11,26H2,1H3,(H,29,30,31)/t14-/m0/s1 BSLTYDLFOUKIBS-AWEZNQCLSA-N 458858 US10759793, Example 11 Tyrosine-protein kinase JAK3 [795-1124] 3.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458858&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587596 441290122 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948085 C[C@H](Nc1nc(nc(OCCO)c1F)-c1cnn2ccccc12)c1ncc(F)cn1 InChI=1S/C19H17F2N7O2/c1-11(16-22-8-12(20)9-23-16)25-18-15(21)19(30-7-6-29)27-17(26-18)13-10-24-28-5-3-2-4-14(13)28/h2-5,8-11,29H,6-7H2,1H3,(H,25,26,27)/t11-/m0/s1 GRHZEIKZXRCYRG-NSHDSACASA-N 458859 US10759793, Example 12 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458859&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587637 441290123 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948088 C[C@H](Nc1nc(nc(OC[C@@H](O)CO)c1F)-c1cnn2ccccc12)c1ncc(F)cn1 InChI=1S/C20H19F2N7O3/c1-11(17-23-6-12(21)7-24-17)26-19-16(22)20(32-10-13(31)9-30)28-18(27-19)14-8-25-29-5-3-2-4-15(14)29/h2-8,11,13,30-31H,9-10H2,1H3,(H,26,27,28)/t11-,13-/m0/s1 RWMMEQKSOCSDOY-AAEUAGOBSA-N 458860 US10759793, Example 13 Tyrosine-protein kinase JAK3 [795-1124] 4.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458860&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125846 441290124 C02773 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948091 OCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C21H22FN7O3/c22-18-20(25-14-4-3-8-28(13-14)17(31)6-7-23)26-19(27-21(18)32-11-10-30)15-12-24-29-9-2-1-5-16(15)29/h1-2,5,9,12,14,30H,3-4,6,8,10-11,13H2,(H,25,26,27)/t14-/m1/s1 VUNHOZNWETWGBW-CQSZACIVSA-N 458861 US10759793, Example 14 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458861&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125716 441290125 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948094 CCCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C23H26FN7O2/c1-2-3-13-33-23-20(24)22(27-16-7-6-11-30(15-16)19(32)9-10-25)28-21(29-23)17-14-26-31-12-5-4-8-18(17)31/h4-5,8,12,14,16H,2-3,6-7,9,11,13,15H2,1H3,(H,27,28,29)/t16-/m1/s1 STQULLLSNFEPER-MRXNPFEDSA-N 458862 US10759793, Example 15 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458862&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125681 441290126 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948097 CCOCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C23H26FN7O3/c1-2-33-12-13-34-23-20(24)22(27-16-6-5-10-30(15-16)19(32)8-9-25)28-21(29-23)17-14-26-31-11-4-3-7-18(17)31/h3-4,7,11,14,16H,2,5-6,8,10,12-13,15H2,1H3,(H,27,28,29)/t16-/m1/s1 NONYWHCEZHZLBC-MRXNPFEDSA-N 458863 US10759793, Example 16 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458863&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125862 441290127 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948100 OCc1ccc(cc1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C26H24FN7O2/c27-23-24(18-8-6-17(16-35)7-9-18)31-25(20-14-29-34-13-2-1-5-21(20)34)32-26(23)30-19-4-3-12-33(15-19)22(36)10-11-28/h1-2,5-9,13-14,19,35H,3-4,10,12,15-16H2,(H,30,31,32)/t19-/m1/s1 NELXXPIFQJKEBR-LJQANCHMSA-N 458864 US10759793, Example 17 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458864&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 118140507 441290128 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948103 Nc1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C24H22FN9O/c25-21-22(15-6-7-19(27)28-12-15)31-23(17-13-29-34-11-2-1-5-18(17)34)32-24(21)30-16-4-3-10-33(14-16)20(35)8-9-26/h1-2,5-7,11-13,16H,3-4,8,10,14H2,(H2,27,28)(H,30,31,32)/t16-/m1/s1 NOFFPXJXUARZEM-MRXNPFEDSA-N 458865 US10759793, Example 18 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458865&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125809 441290129 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948106 COc1ccc(cn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H23FN8O2/c1-36-20-8-7-16(13-28-20)23-22(26)25(30-17-5-4-11-33(15-17)21(35)9-10-27)32-24(31-23)18-14-29-34-12-3-2-6-19(18)34/h2-3,6-8,12-14,17H,4-5,9,11,15H2,1H3,(H,30,31,32)/t17-/m1/s1 CYNWAOAKNNUGQL-QGZVFWFLSA-N 458866 US10759793, Example 19 Tyrosine-protein kinase JAK3 [795-1124] 2.00 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458866&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125730 441290130 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948109 Cc1cc(ccn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 InChI=1S/C25H23FN8O/c1-16-13-17(8-10-28-16)23-22(26)25(30-18-5-4-11-33(15-18)21(35)7-9-27)32-24(31-23)19-14-29-34-12-3-2-6-20(19)34/h2-3,6,8,10,12-14,18H,4-5,7,11,15H2,1H3,(H,30,31,32)/t18-/m1/s1 SFTBRNQQYRPRFI-GOSISDBHSA-N 458867 US10759793, Example 20 Tyrosine-protein kinase JAK3 [795-1124] 1.000 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458867&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134587626 441290131 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 948112 CN([C@@H]1CCCN(C1)C(=O)CC#N)c1nc(nc(-c2ccnc(C)c2)c1F)-c1cnn2ccccc12 InChI=1S/C26H25FN8O/c1-17-14-18(9-11-29-17)24-23(27)26(33(2)19-6-5-12-34(16-19)22(36)8-10-28)32-25(31-24)20-15-30-35-13-4-3-7-21(20)35/h3-4,7,9,11,13-15,19H,5-6,8,12,16H2,1-2H3/t19-/m1/s1 OJOMLCDNWMYVFZ-LJQANCHMSA-N 458868 US10759793, Example 21 Tyrosine-protein kinase JAK3 [795-1124] 11.0 US Patent 10.7270/Q2QC06MG aid1804760 US10759793 Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B Almirall, S.A. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=458868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=927&target=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=458868&enzyme=Tyrosine-protein+kinase+JAK3+%5B795-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 124125717 441290132 1 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,7C3N Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2