BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID of Ligand	PubChem SID of Ligand	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
66638	CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O	InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)	PIQCTGMSNWUMAF-UHFFFAOYSA-N	25118	(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258	5'-AMP-activated protein kinase catalytic subunit alpha-2				 820						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9886808	56374260		CHEMBL522892		5962		ZINC03816310	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66639	Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F	InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)	KDKUVYLMPJIGKA-UHFFFAOYSA-N	6866	1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790	5'-AMP-activated protein kinase catalytic subunit alpha-2				 1800						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	SKE	5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0	5330790	8036422		CHEMBL191003				ZINC03938688	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66640	CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1	InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1	BMGQWWVMWDBQGC-PZFYLCKJSA-N	31094	PKC-412::cid_24202429	5'-AMP-activated protein kinase catalytic subunit alpha-2				 460						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31094&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			24202429	242052840							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66641	Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1	InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1	CTNPALGJUAXMMC-PMFHANACSA-N	31095	5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259	5'-AMP-activated protein kinase catalytic subunit alpha-2				 290						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10138259	252615339						ZINC18825344	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66642	CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13	InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1	HKSZLNNOFSGOKW-HMWZOHBLSA-N	31096	CHEMBL290084::Staurosporine::cid_451705	5'-AMP-activated protein kinase catalytic subunit alpha-2				 12						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			451705	242052841		CHEMBL290084		346		ZINC05615681	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66643	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WINHZLLDWRZWRT-ATVHPVEESA-N	4814	CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248	5'-AMP-activated protein kinase catalytic subunit alpha-2				 89						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B49	6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD	5329102	8034462	38940	CHEMBL535	DB01268	5713		ZINC03964325	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
66644	CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1	InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	GCIKSSRWRFVXBI-UHFFFAOYSA-N	13534	CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide	5'-AMP-activated protein kinase catalytic subunit alpha-2				 350						PubChem		10.7270/Q2PK0DJT		aid1433		PubChem, PC	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	VX6	2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN	5494449	46513935		CHEMBL572878		5718		ZINC03820040	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425911	COc1ccc(CN2CCC(CC2)c2ccc3[nH]c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H35F3N6O2/c1-43-29-9-4-23(19-36-29)21-39-12-10-24(11-13-39)25-5-8-27-28(18-25)38-30(37-27)31(42)41-16-14-40(15-17-41)20-22-2-6-26(7-3-22)32(33,34)35/h2-9,18-19,24H,10-17,20-21H2,1H3,(H,37,38)	KKRRTZFDLYCBDK-UHFFFAOYSA-N	244219	US9428501, 1	5'-AMP-activated protein kinase catalytic subunit alpha-2					 24				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244219&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86292820	341095854							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425912	COc1cnc(CN2CCC(CC2)c2ccc3[nH]c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C31H34F3N7O2/c1-43-28-18-35-25(17-36-28)20-39-10-8-22(9-11-39)23-4-7-26-27(16-23)38-29(37-26)30(42)41-14-12-40(13-15-41)19-21-2-5-24(6-3-21)31(32,33)34/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,37,38)	WTVQQXGHNYQSSQ-UHFFFAOYSA-N	244220	US9428501, 7	5'-AMP-activated protein kinase catalytic subunit alpha-2					 8.3				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244220&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581756	341095855							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425913	COc1cnc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C31H34F3N7O2/c1-43-28-18-35-25(17-36-28)20-39-10-8-22(9-11-39)23-4-7-26-27(16-23)38-29(37-26)30(42)41-14-12-40(13-15-41)19-21-2-5-24(6-3-21)31(32,33)34/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,37,38)	WTVQQXGHNYQSSQ-UHFFFAOYSA-N	244221	US9428501, 8	5'-AMP-activated protein kinase catalytic subunit alpha-2					 13				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244221&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581756	341095856							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425914	COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1	InChI=1S/C33H36F3N5O2/c1-43-28-9-4-24(5-10-28)21-39-14-12-25(13-15-39)26-6-11-29-30(20-26)38-31(37-29)32(42)41-18-16-40(17-19-41)22-23-2-7-27(8-3-23)33(34,35)36/h2-11,20,25H,12-19,21-22H2,1H3,(H,37,38)	DCOPJZULHMHERN-UHFFFAOYSA-N	244222	US9428501, 14	5'-AMP-activated protein kinase catalytic subunit alpha-2					 34				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244222&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378659	341095857							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425915	COc1ccc(CN2CCC(CC2)c2ccc3nc(C(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)n(C)c3c2)cn1	InChI=1S/C33H37F3N6O2/c1-39-29-19-26(25-11-13-40(14-12-25)22-24-5-10-30(44-2)37-20-24)6-9-28(29)38-31(39)32(43)42-17-15-41(16-18-42)21-23-3-7-27(8-4-23)33(34,35)36/h3-10,19-20,25H,11-18,21-22H2,1-2H3	OACVUEQJCDUMED-UHFFFAOYSA-N	244223	US9428501, 18	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3.0				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244223&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118397047	341095858							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425916	COc1ccc(CN2CCC(CC2)c2ccc3n(C)c(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C33H37F3N6O2/c1-39-29-9-6-26(25-11-13-40(14-12-25)22-24-5-10-30(44-2)37-20-24)19-28(29)38-31(39)32(43)42-17-15-41(16-18-42)21-23-3-7-27(8-4-23)33(34,35)36/h3-10,19-20,25H,11-18,21-22H2,1-2H3	KZBWOIGKOYKULA-UHFFFAOYSA-N	244224	US9428501, 19	5'-AMP-activated protein kinase catalytic subunit alpha-2					 10				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244224&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118397064	341095859							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425917	COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1	InChI=1S/C32H35N7O2/c1-41-30-9-6-25(20-34-30)22-37-12-10-26(11-13-37)27-7-8-28-29(18-27)36-31(35-28)32(40)39-16-14-38(15-17-39)21-24-4-2-23(19-33)3-5-24/h2-9,18,20,26H,10-17,21-22H2,1H3,(H,35,36)	FZCFJOURTVGXMQ-UHFFFAOYSA-N	244225	US9428501, 23	5'-AMP-activated protein kinase catalytic subunit alpha-2					 19				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244225&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378646	341095860							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425918	COc1ccc(CN2CCC(CC2)c2ccc3nc(cn3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H35F3N6O2/c1-43-30-9-4-24(18-36-30)20-38-12-10-25(11-13-38)26-5-8-29-37-28(22-41(29)21-26)31(42)40-16-14-39(15-17-40)19-23-2-6-27(7-3-23)32(33,34)35/h2-9,18,21-22,25H,10-17,19-20H2,1H3	RETWRVKEUUJUIZ-UHFFFAOYSA-N	244226	US9428501, 35	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3.6				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244226&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118397117	341095861							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425919	COc1ccc(CN2CCC(CC2)c2ccn3cc(nc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H35F3N6O2/c1-43-30-7-4-24(19-36-30)21-38-11-8-25(9-12-38)26-10-13-41-22-28(37-29(41)18-26)31(42)40-16-14-39(15-17-40)20-23-2-5-27(6-3-23)32(33,34)35/h2-7,10,13,18-19,22,25H,8-9,11-12,14-17,20-21H2,1H3	VJJLOEINUZTPPF-UHFFFAOYSA-N	244227	US9428501, 36	5'-AMP-activated protein kinase catalytic subunit alpha-2					 5.1				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244227&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581758	341095862							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425920	COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc4OC(F)(F)Oc4c3)CC2)cn1	InChI=1S/C32H34F2N6O4/c1-42-29-7-3-22(18-35-29)20-38-10-8-23(9-11-38)24-4-5-25-26(17-24)37-30(36-25)31(41)40-14-12-39(13-15-40)19-21-2-6-27-28(16-21)44-32(33,34)43-27/h2-7,16-18,23H,8-15,19-20H2,1H3,(H,36,37)	MKUPLUBCIIGNHP-UHFFFAOYSA-N	244228	US9428501, 37	5'-AMP-activated protein kinase catalytic subunit alpha-2					 10				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244228&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378640	341095863							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425921	COc1ccc(CN2CCC(CC2)c2ccc3nc([nH]c3c2)C(=O)N2CCN(Cc3ccc(cc3F)C(F)(F)F)CC2)cn1	InChI=1S/C32H34F4N6O2/c1-44-29-7-2-21(18-37-29)19-40-10-8-22(9-11-40)23-4-6-27-28(16-23)39-30(38-27)31(43)42-14-12-41(13-15-42)20-24-3-5-25(17-26(24)33)32(34,35)36/h2-7,16-18,22H,8-15,19-20H2,1H3,(H,38,39)	YSDOFGBITHORQK-UHFFFAOYSA-N	244229	US9428501, 38	5'-AMP-activated protein kinase catalytic subunit alpha-2					 13				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244229&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378655	341095864							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425922	COc1ccc(CN2CCC(CC2)c2cc3cc(C(=O)N4CCN(Cc5ccc(cc5)C(F)(F)F)CC4)n(C)c3cn2)cn1	InChI=1S/C33H37F3N6O2/c1-39-29(32(43)42-15-13-41(14-16-42)21-23-3-6-27(7-4-23)33(34,35)36)18-26-17-28(37-20-30(26)39)25-9-11-40(12-10-25)22-24-5-8-31(44-2)38-19-24/h3-8,17-20,25H,9-16,21-22H2,1-2H3	IZGIMVUPYNRKHM-UHFFFAOYSA-N	244230	US9428501, 44	5'-AMP-activated protein kinase catalytic subunit alpha-2					 5.2				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244230&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378670	341095865							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425923	COc1ccc(CN2CCC(CC2)c2ccn3nc(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H35F3N6O2/c1-43-30-7-4-24(20-36-30)22-38-11-8-25(9-12-38)26-10-13-41-28(18-26)19-29(37-41)31(42)40-16-14-39(15-17-40)21-23-2-5-27(6-3-23)32(33,34)35/h2-7,10,13,18-20,25H,8-9,11-12,14-17,21-22H2,1H3	RDVWCZZSJCEHTP-UHFFFAOYSA-N	244231	US9428501, 49	5'-AMP-activated protein kinase catalytic subunit alpha-2					 6.5				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244231&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378634	341095866							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425924	COc1cnc(CN2CCC(CC2)c2ccn3nc(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C31H34F3N7O2/c1-43-29-19-35-26(18-36-29)21-38-9-6-23(7-10-38)24-8-11-41-27(16-24)17-28(37-41)30(42)40-14-12-39(13-15-40)20-22-2-4-25(5-3-22)31(32,33)34/h2-5,8,11,16-19,23H,6-7,9-10,12-15,20-21H2,1H3	ZNDKEFQVZIOPLS-UHFFFAOYSA-N	244232	US9428501, 50	5'-AMP-activated protein kinase catalytic subunit alpha-2					 14				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244232&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378672	341095867							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425925	COc1ccc(CN2CCC(CC2)n2cc3cc(ccc3n2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H35F3N6O2/c1-43-30-9-4-24(19-36-30)21-38-12-10-28(11-13-38)41-22-26-18-25(5-8-29(26)37-41)31(42)40-16-14-39(15-17-40)20-23-2-6-27(7-3-23)32(33,34)35/h2-9,18-19,22,28H,10-17,20-21H2,1H3	WIHQKPXLISMAJC-UHFFFAOYSA-N	244233	US9428501, 57	5'-AMP-activated protein kinase catalytic subunit alpha-2					 1.8				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244233&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378629	341095868							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425926	CCOc1cnc(CN2CCC(CC2)n2cc3cc(ccc3n2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1	InChI=1S/C32H36F3N7O2/c1-2-44-30-19-36-27(18-37-30)22-39-11-9-28(10-12-39)42-21-25-17-24(5-8-29(25)38-42)31(43)41-15-13-40(14-16-41)20-23-3-6-26(7-4-23)32(33,34)35/h3-8,17-19,21,28H,2,9-16,20,22H2,1H3	QSBPMVRDJQONFS-UHFFFAOYSA-N	244234	US9428501, 58	5'-AMP-activated protein kinase catalytic subunit alpha-2					 0.86				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244234&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			118378631	341095869							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425927	CCOc1cnc(CN2CCC(CC2)c2ccc3n(C)c(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1	InChI=1S/C34H39N7O2/c1-3-43-33-22-36-30(21-37-33)24-39-12-10-27(11-13-39)28-8-9-31-29(18-28)19-32(38(31)2)34(42)41-16-14-40(15-17-41)23-26-6-4-25(20-35)5-7-26/h4-9,18-19,21-22,27H,3,10-17,23-24H2,1-2H3	HCOXUYKXGCQDAS-UHFFFAOYSA-N	244235	US9428501, 66	5'-AMP-activated protein kinase catalytic subunit alpha-2					 2.8				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244235&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581908	341095870							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425928	CCOc1cnc(CN2CCC(CC2)c2ccc3cc(C(=O)N4CCN(Cc5ccc(cc5)C#N)CC4)n(C)c3c2)cn1	InChI=1S/C34H39N7O2/c1-3-43-33-22-36-30(21-37-33)24-39-12-10-27(11-13-39)28-8-9-29-19-32(38(2)31(29)18-28)34(42)41-16-14-40(15-17-41)23-26-6-4-25(20-35)5-7-26/h4-9,18-19,21-22,27H,3,10-17,23-24H2,1-2H3	UKEFJBWFBLUBFV-UHFFFAOYSA-N	244236	US9428501, 69	5'-AMP-activated protein kinase catalytic subunit alpha-2					 1.8				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244236&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581909	341095871							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
425929	COc1cnc(CN2CCC(CC2)c2ccc3n(C)c(cc3c2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cn1	InChI=1S/C33H37N7O2/c1-37-30-8-7-27(26-9-11-38(12-10-26)23-29-20-36-32(42-2)21-35-29)17-28(30)18-31(37)33(41)40-15-13-39(14-16-40)22-25-5-3-24(19-34)4-6-25/h3-8,17-18,20-21,26H,9-16,22-23H2,1-2H3	MDJLGEJZNYDGLD-UHFFFAOYSA-N	244237	US9428501, 79	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3.3				37.00 C	US Patent		10.7270/Q28051JK		aid1803352	US9428501	Ohnuki, K; Azami, H; Sawada, Y; Shin, T; Kuramoto, K; Kikuchi, S; Saito, T; Hamaguchi, H; Nagashima, T	Astellas Pharma Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=244237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=244237&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			86581910	341095872							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50167502	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1	InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1	BMGQWWVMWDBQGC-IIFHNQTCSA-N	50326053	CHEMBL608533::PKC-412	5'-AMP-activated protein kinase catalytic subunit alpha-2				 460						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2K2	4NCT	9829523	123105168	63452	CHEMBL608533					1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50166173	C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13	InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1	UIARLYUEJFELEN-LROUJFHJSA-N	50308060	16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701	5'-AMP-activated protein kinase catalytic subunit alpha-2				 56						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2V9	5WNJ,4OTG	126565	104162421		CHEMBL603469		5672		ZINC03781738	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50185849	COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1	InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-	XZXHXSATPCNXJR-ZIADKAODSA-N	50026612	BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef	5'-AMP-activated protein kinase catalytic subunit alpha-2				 84						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	XIN	5MAF,6NEC,3C7Q,5TE0	9809715	277286638							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50189161	C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13	InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1	UIARLYUEJFELEN-LROUJFHJSA-N	50308060	16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701	5'-AMP-activated protein kinase catalytic subunit alpha-2				 56						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2V9	5WNJ,4OTG	126565	104162421		CHEMBL603469		5672		ZINC03781738	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50196627	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1	InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1	BMGQWWVMWDBQGC-IIFHNQTCSA-N	50326053	CHEMBL608533::PKC-412	5'-AMP-activated protein kinase catalytic subunit alpha-2				 460						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2K2	4NCT	9829523	123105168	63452	CHEMBL608533					1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50191372	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13	InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	HKSZLNNOFSGOKW-FYTWVXJKSA-N	2579	(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine	5'-AMP-activated protein kinase catalytic subunit alpha-2				 12						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	STO	1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC	44259	8032349	15738	CHEMBL388978		346	C02079	ZINC03814434	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50227646	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1	InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1	BMGQWWVMWDBQGC-IIFHNQTCSA-N	50326053	CHEMBL608533::PKC-412	5'-AMP-activated protein kinase catalytic subunit alpha-2				 460						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2K2	4NCT	9829523	123105168	63452	CHEMBL608533					1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50229912	CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13	InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	HKSZLNNOFSGOKW-FYTWVXJKSA-N	2579	(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine	5'-AMP-activated protein kinase catalytic subunit alpha-2				 12						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	STO	1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC	44259	8032349	15738	CHEMBL388978		346	C02079	ZINC03814434	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50456140	O[C@H]1CC[C@@H](CC1)c1[nH]ncc1-c1ccnc(NC2CCCC2)n1	InChI=1S/C18H25N5O/c24-14-7-5-12(6-8-14)17-15(11-20-23-17)16-9-10-19-18(22-16)21-13-3-1-2-4-13/h9-14,24H,1-8H2,(H,20,23)(H,19,21,22)/t12-,14-	JCJAEEODSKNKTC-MQMHXKEQSA-N	50277910	4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanol::CHEMBL507249	5'-AMP-activated protein kinase catalytic subunit alpha-2			>30000							ChEMBL	10.1016/j.bmcl.2009.03.023	10.7270/Q26H4H9D	19327989			Humphries, PS; Lafontaine, JA; Agree, CS; Alexander, D; Chen, P; Do, QQ; Li, LY; Lunney, EA; Rajapakse, RJ; Siegel, K; Timofeevski, SL; Wang, T; Wilhite, DM	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277910&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			44591740	104120373		CHEMBL507249				ZINC40379254	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50596975	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WINHZLLDWRZWRT-ATVHPVEESA-N	4814	CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248	5'-AMP-activated protein kinase catalytic subunit alpha-2				 89						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B49	6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD	5329102	8034462	38940	CHEMBL535	DB01268	5713		ZINC03964325	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50595822	COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1	InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)	UXXQOJXBIDBUAC-UHFFFAOYSA-N	13535	4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			3038522	46513936		CHEMBL124660	DB05465			ZINC03966243	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50596076	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1	InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1	ZZSBPGIGIUFJRA-AKIDMACVSA-N	50326054	CHEMBL1240703	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			52945601	123105169		CHEMBL1240703					1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50595338	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1	InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	MLDQJTXFUGDVEO-UHFFFAOYSA-N	16673	4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	BAX	3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF	216239	46516901	50924	CHEMBL1336	DB00398	5711		ZINC01493878	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50596883	CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1	InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	CVWXJKQAOSCOAB-UHFFFAOYSA-N	50300690	1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound)	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1182/blood-2009-05-222034	10.7270/Q2PN95V2	19654408			Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	P30	4XUF,4RT7	24889392	104155051		CHEMBL576982		5658		ZINC43204002	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50666864	COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC	InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)	AAKJLRGGTJKAMG-UHFFFAOYSA-N	5446	CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	AQ4	4HJO,6DWN,1M17	176870	8035065	114785	CHEMBL553	DB00530	4920		ZINC01546066	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50666951	Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1	InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1	CTNPALGJUAXMMC-PMFHANACSA-N	31095	5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259	5'-AMP-activated protein kinase catalytic subunit alpha-2				 290						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10138259	252615339						ZINC18825344	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50668810	C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl	InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1	KTEIFNKAUNYNJU-GFCCVEGCSA-N	50306682	(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	VGH	2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ	11626560	104161043	64310	CHEMBL601719	DB08700	4903		ZINC35902489	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50667473	CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1	InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)	VAARYSWULJUGST-UHFFFAOYSA-N	6568	6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	P17	1M52,5IA3	447077	8036145	49791	CHEMBL386051	DB02567	5699		ZINC02047743	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50666280	CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1	InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	KTUFNOKKBVMGRW-UHFFFAOYSA-N	13530	4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	STI	6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ	5291	46513933	45783	CHEMBL941	DB00619	5687		ZINC19632618	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50666295	CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12	InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)	RAHBGWKEPAQNFF-UHFFFAOYSA-N	24773	AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	706	3EFL	11667893	56269724	51098			5660		ZINC18710082	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50667613	O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1	InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+	YYLKKYCXAOBSRM-JXMROGBWSA-N	50355496	CHEMBL1908397	5'-AMP-activated protein kinase catalytic subunit alpha-2				 440						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11427553	136959520		CHEMBL1908397				ZINC43201999	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50667641	CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F	InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)	YZDJQTHVDDOVHR-UHFFFAOYSA-N	25617	N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	324	3C4C,4WO5	24180719	56412907			DB06999	5703		ZINC39059267	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50669215	C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N	InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	UJLAWZDWDVHWOW-YPMHNXCESA-N	50193995	3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	MI1	3LXK,3LXN,4OTI,3EYG,3FUP	9926791	104076339	71200	CHEMBL221959	DB08183	5677		ZINC03818808	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50669490	CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1	InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)	WJEOLQLKVOPQFV-UHFFFAOYSA-N	50355495	CHEMBL1908391	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	G65	7TVX,5MQL,7JU7	10074640	136959519	63450	CHEMBL1908391				ZINC34177219	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50692497	CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1	InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)	ODPGGGTTYSGTGO-UHFFFAOYSA-N	31085	1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11409972	252615335				5661		ZINC23247639	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50673927	OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1	InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)	HHFBDROWDBDFBR-UHFFFAOYSA-N	31093	4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	ZZL	2X81,5IA1,2WTW,2WTV	11712649	252615338		CHEMBL259084		5696		ZINC18825334	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50676868	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1	InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	MLDQJTXFUGDVEO-UHFFFAOYSA-N	16673	4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	BAX	3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF	216239	46516901	50924	CHEMBL1336	DB00398	5711		ZINC01493878	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50683927	COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl	InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)	UBPYILGKFZZVDX-UHFFFAOYSA-N	4552	4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	DB8	6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY	5328940	8034215	39112	CHEMBL288441	DB06616	5710		ZINC22448983	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50688284	COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1	InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)	MYQAUKPBNJWPIE-UHFFFAOYSA-N	32362	5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	MUJ	4AT5	11617559	252615797				5685		ZINC13985942	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50675543	C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C	InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1	WCWUXEGQKLTGDX-LLVKDONJSA-N	50184807	(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11234052	104069124		CHEMBL377300		5671		ZINC13684256	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50675565	COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1	InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)	UXXQOJXBIDBUAC-UHFFFAOYSA-N	13535	4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			3038522	46513936		CHEMBL124660	DB05465			ZINC03966243	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50684143	Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO	InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)	CYOHGALHFOKKQC-UHFFFAOYSA-N	50355497	AZD-6244::CHEMBL1614701	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	3EW	4U7Z,7JUZ,7JUT,7M0T	10127622	136959521		CHEMBL1614701				ZINC31773258	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50686895	CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl	InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1	BIIVYFLTOXDAOV-YVEFUNNKSA-N	5655	2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	CPB	1C8K,1E1Y,3BLR,3EBP,4O71	5287969	8035270		CHEMBL428690	DB03496	5680		ZINC21288966	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50677188	COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C	InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25)	ZNOLRTPMNMPLHY-UHFFFAOYSA-N	50309910	CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9929127	104164271		CHEMBL608154		5694		ZINC06717113	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50678525	Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12	InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)	YABJJWZLRMPFSI-UHFFFAOYSA-N	31088	1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	55J	5CT7	11656518	252615336				5674		ZINC18710085	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50684220	COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1	InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	SEJGTFPOEJWEGG-UHFFFAOYSA-N	50355504	CHEMBL1908393	5'-AMP-activated protein kinase catalytic subunit alpha-2				 1200						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			57399640	136959528		CHEMBL1908393				ZINC73140828	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50669883	CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12	InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)	HZTYDQRUAWIZRE-UHFFFAOYSA-N	27817	2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			25182616	57560329				5683		ZINC43202844	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50671265	CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O	InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1	XQVVPGYIWAGRNI-JOCHJYFZSA-N	25121	4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	R78	4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M	11364421	56374263		CHEMBL513909		5666		ZINC13986815	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50680058	COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1	InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)	QQWUGDVOUVUTOY-UHFFFAOYSA-N	482158	BDBM50242742::TAE684	5'-AMP-activated protein kinase catalytic subunit alpha-2				 49						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			16038120	443551321							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50687084	CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N	InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1	KGPGFQWBCSZGEL-ZDUSSCGKSA-N	25013	4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	G93	3D0E,5U94	16725726	56374157				5196		ZINC34285211	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50678748	CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1	InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)	GUBJNPWVIUFSTR-UHFFFAOYSA-N	50355499	CHEMBL1908395::CHEMBL1908842	5'-AMP-activated protein kinase catalytic subunit alpha-2				 4.1						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11676971	136959523		CHEMBL1908842CHEMBL1908395				ZINC38226716	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50691581	Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1	InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1	BPNUQXPIQBZCMR-IBGZPJMESA-N	15138	5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	SS3	2UZT	11314340	46515449			DB08568	5655		ZINC16052569	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50675906	CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1	InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)	BCFGMOOMADDAQU-UHFFFAOYSA-N	5445	CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	FMM	1XKK,3BBT	208908	8035064	49603	CHEMBL554	DB01259	5692		ZINC01550477	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50688882	Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl	InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)	OMZCMEYTWSXEPZ-UHFFFAOYSA-N	4779	CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			156414	8034429	61399	CHEMBL31965CHEMBL545315	DB05424	5675		ZINC27439698	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50690424	COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1	InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3	XXJWYDDUDKYVKI-UHFFFAOYSA-N	50331096	4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9933475	123110211		CHEMBL491473	DB04849	5664		ZINC03948085	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50690467	Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1	InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1	OYONTEXKYJZFHA-SSHUPFPWSA-N	50242737	(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885	5'-AMP-activated protein kinase catalytic subunit alpha-2				 770						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10461815	104099202		CHEMBL450786		5700		ZINC03938668	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50673214	Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1	InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)	UJIAQDJKSXQLIT-UHFFFAOYSA-N	25084	3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B6J	5WNK	10427712	56374226				5715		ZINC06718666	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50685905	Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1	InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3	BCZUAADEACICHN-UHFFFAOYSA-N	60589	6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	SX8	3DKF,3DKG	16187854	24782328			DB08584			ZINC15962404	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50676162	CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O	InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)	PIQCTGMSNWUMAF-UHFFFAOYSA-N	25118	(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258	5'-AMP-activated protein kinase catalytic subunit alpha-2				 820						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9886808	56374260		CHEMBL522892		5962		ZINC03816310	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50683398	CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21	InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1	ZCBUQCWBWNUWSU-SFHVURJKSA-N	17055	(18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	LY4	2J2I,1UU3	153999	46517285				5263		ZINC03812168	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50673394	CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1	InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	CVWXJKQAOSCOAB-UHFFFAOYSA-N	50300690	1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound)	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	P30	4XUF,4RT7	24889392	104155051		CHEMBL576982		5658		ZINC43204002	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50676363	Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1	InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2	TUVCWJQQGGETHL-UHFFFAOYSA-N	25045	3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	X6K	2X6K,4L23,4JT6	9884685	56374189		CHEMBL538346		5701		ZINC03963016	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50686117	CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1	InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+	RITAVMQDGBJQJZ-FMIVXFBMSA-N	25117	AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			6450551	56374259	66910			5659		ZINC03816287	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50690803	Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F	InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)	GFMMXOIFOQCCGU-UHFFFAOYSA-N	50132260	2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			6918454	104023279		CHEMBL105442		5676		ZINC01489691	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50676501	Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1	InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H	VEPKQEUBKLEPRA-UHFFFAOYSA-N	15244	5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	52P	3ZSI,3HP5,3FC1	3038525	46515551			DB07138			ZINC13493055	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50679364	C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F	InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1	ZHJGWYRLJUCMRT-QGZVFWFLSA-N	50355500	CHEMBL1908394::US9695172, GSK461364	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			15983966	136959524		CHEMBL1908394				ZINC43154472	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50686282	Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1	InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)	OVPNQJVDAFNBDN-UHFFFAOYSA-N	24654	4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	LZE	7AGA,2VU3	11338033	56269605				5662		ZINC16052857	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50670638	CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1	InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)	QYZOGCMHVIGURT-UHFFFAOYSA-N	26300	2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	YJA	4C2V	16007391	56464737		CHEMBL215152		5663		ZINC16697102	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50675053	COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC	InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)	NHHQJBCNYHBUSI-UHFFFAOYSA-N	60665	BDBM50249542::US9145414, R406::US9212178, R406	5'-AMP-activated protein kinase catalytic subunit alpha-2				 750						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	585	3PIY,3FQS	11213558	316921779			DB07159			ZINC13555629	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50676597	Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1	InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)	ZBNZXTGUTAYRHI-UHFFFAOYSA-N	13216	BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	1N1	5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U	3062316	46513626	49375	CHEMBL1421	DB01254	5678		ZINC21982951	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50680747	N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12	InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1	HFNKQEVNSGCOJV-OAHLLOKOSA-N	50355501	INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	RXT	6VNK,6WTN,6VGL,4U5J,7F3G	25126798	136959525	66919		DB08877			ZINC43207851	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50682318	CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1	InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)	OUSFTKFNBAZUKL-UHFFFAOYSA-N	5931	BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	56H	5D1J	3025986	8035540		CHEMBL296468		5670		ZINC03816409	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50685032	CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1	InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)	CDMGBJANTYXAIV-UHFFFAOYSA-N	13336	4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search		1A9U,1PME,2EWA	176155	46513744		CHEMBL10		5269		ZINC96006137	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50689482	COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1	InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29)	SHPFDGWALWEPGS-UHFFFAOYSA-N	50355494	CHEMBL1908396	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9869779	136959518		CHEMBL1908396				ZINC13975055	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50675178	Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C	InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)	JOOXLOJCABQBSG-UHFFFAOYSA-N	50332294	CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5	5'-AMP-activated protein kinase catalytic subunit alpha-2				 4700						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	2TA	4OGJ,4PS5,6VNE	16722836	123111409		CHEMBL1287853		5716		ZINC19862646	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50682416	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1	InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)	XGALLCVXEZPNRQ-UHFFFAOYSA-N	5447	CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search		2ITO,2ITY,2ITZ	123631	8035066	49668	CHEMBL939	DB00317	4941		ZINC19632614	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50689580	CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12	InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19)	MFAQYJIYDMLAIM-UHFFFAOYSA-N	36409	2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	P2X	4JT5	24905147	117643995						ZINC36056301	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50691032	CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1	InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)	LHNIIDJUOCFXAP-UHFFFAOYSA-N	25028	4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	GD9	3DBS,2Y3A,2WXP	17755052	56374172	65326					ZINC16052714	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50692355	COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1	InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)	UHTHHESEBZOYNR-UHFFFAOYSA-N	21	CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	ZD6	2IVU	3081361	8030012	49960	CHEMBL24828	DB08764			ZINC03834198	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50692430	Cc1cnc2c(NCCN)nc3ccc(C)cc3n12	InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18)	PSPFQEBFYXJZEV-UHFFFAOYSA-N	25919	BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9813758	56413207		CHEMBL471496		5669		ZINC13285379	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50672412	Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12	InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)	AXRCEOKUDYDWLF-UHFFFAOYSA-N	50128285	3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138	5'-AMP-activated protein kinase catalytic subunit alpha-2				 5000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			176167	104020050		CHEMBL300138		5693		ZINC01494900	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50673790	Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1	InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	MPVGZUGXCQEXTM-UHFFFAOYSA-N	21079	1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11485656	49689152		CHEMBL223360		5657		ZINC06718813	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50679570	OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O	InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2	RIGIGAFKKVBACY-UHFFFAOYSA-N	25628	2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			91448975	56412918		CHEMBL525191				ZINC34640412	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50696616	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WINHZLLDWRZWRT-ATVHPVEESA-N	4814	CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248	5'-AMP-activated protein kinase catalytic subunit alpha-2				 89						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B49	6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD	5329102	8034462	38940	CHEMBL535	DB01268	5713		ZINC03964325	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50693995	Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C	InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)	MVCOAUNKQVWQHZ-UHFFFAOYSA-N	13533	1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B96	4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS	156422	46513934		CHEMBL103667	DB03044	5668		ZINC24044436	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50694104	Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1	InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)	YCOYDOIWSSHVCK-UHFFFAOYSA-N	4851	(4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			151194	8034494		CHEMBL75232CHEMBL101253	DB04879	6052		ZINC00007460	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50697008	CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1	InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	GCIKSSRWRFVXBI-UHFFFAOYSA-N	13534	CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide	5'-AMP-activated protein kinase catalytic subunit alpha-2				 350						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	VX6	2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN	5494449	46513935		CHEMBL572878		5718		ZINC03820040	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50697078	CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C	InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+	JWNPDZNEKVCWMY-VQHVLOKHSA-N	50161957	4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9915743	104048227		CHEMBL180022		5686		ZINC03916214	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50694358	CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1	ULXXDDBFHOBEHA-CWDCEQMOSA-N	50322823	(S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	0WM	4G5J	10184653	104144352	61390	CHEMBL1173655	DB08916	5667		ZINC03976838	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50694517	COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N	InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24)	JRNJNYBQQYBCLE-UHFFFAOYSA-N	12621	2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	LIA	2FVD	6918852	46513075			DB08094	5707		ZINC13983251	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50697268	Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F	InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)	HHZIURLSWUIHRB-UHFFFAOYSA-N	50237710	4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	NIL	5MO4,3CS9,3GP0	644241	104056419	52172	CHEMBL255863	DB04868	5697		ZINC06716957	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50695202	CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1	InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)	CUIHSIWYWATEQL-UHFFFAOYSA-N	26474	5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt.1990	10.7270/Q25D8S70	22037378			Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10113978	56464911	71219		DB06589	5698		ZINC11617039	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895610	Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1	InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)	MPVGZUGXCQEXTM-UHFFFAOYSA-N	21079	1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11485656	49689152		CHEMBL223360		5657		ZINC06718813	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895611	CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12	InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)	RAHBGWKEPAQNFF-UHFFFAOYSA-N	24773	AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	706	3EFL	11667893	56269724	51098			5660		ZINC18710082	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895612	CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1	InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)	ODPGGGTTYSGTGO-UHFFFAOYSA-N	31085	1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11409972	252615335				5661		ZINC23247639	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895613	CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1	InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)	QYZOGCMHVIGURT-UHFFFAOYSA-N	26300	2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	YJA	4C2V	16007391	56464737		CHEMBL215152		5663		ZINC16697102	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895614	Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C	InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)	MVCOAUNKQVWQHZ-UHFFFAOYSA-N	13533	1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B96	4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS	156422	46513934		CHEMBL103667	DB03044	5668		ZINC24044436	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895615	CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1	InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)	OUSFTKFNBAZUKL-UHFFFAOYSA-N	5931	BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	56H	5D1J	3025986	8035540		CHEMBL296468		5670		ZINC03816409	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895616	CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O	InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)	PIQCTGMSNWUMAF-UHFFFAOYSA-N	25118	(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258	5'-AMP-activated protein kinase catalytic subunit alpha-2				 820						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9886808	56374260		CHEMBL522892		5962		ZINC03816310	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895617	Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12	InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)	YABJJWZLRMPFSI-UHFFFAOYSA-N	31088	1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	55J	5CT7	11656518	252615336				5674		ZINC18710085	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895618	Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl	InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)	OMZCMEYTWSXEPZ-UHFFFAOYSA-N	4779	CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			156414	8034429	61399	CHEMBL31965CHEMBL545315	DB05424	5675		ZINC27439698	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895619	C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N	InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1	UJLAWZDWDVHWOW-YPMHNXCESA-N	50193995	3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	MI1	3LXK,3LXN,4OTI,3EYG,3FUP	9926791	104076339	71200	CHEMBL221959	DB08183	5677		ZINC03818808	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895620	COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1	InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+	LLVZBTWPGQVVLW-SNAWJCMRSA-N	31340	2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			9874913	252615341		CHEMBL483321				ZINC03817105	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895621	Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1	InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)	ZBNZXTGUTAYRHI-UHFFFAOYSA-N	13216	BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	1N1	5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U	3062316	46513626	49375	CHEMBL1421	DB01254	5678		ZINC21982951	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895622	CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C	InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+	WVUNYSQLFKLYNI-AATRIKPKSA-N	31090	(E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	93J	7AXM,5VCW	6445562	252615337	38927					ZINC00602803	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895623	COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC	InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)	AAKJLRGGTJKAMG-UHFFFAOYSA-N	5446	CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	AQ4	4HJO,6DWN,1M17	176870	8035065	114785	CHEMBL553	DB00530	4920		ZINC01546066	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895624	CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl	InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1	BIIVYFLTOXDAOV-YVEFUNNKSA-N	5655	2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	CPB	1C8K,1E1Y,3BLR,3EBP,4O71	5287969	8035270		CHEMBL428690	DB03496	5680		ZINC21288966	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895625	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1	InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)	XGALLCVXEZPNRQ-UHFFFAOYSA-N	5447	CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search		2ITO,2ITY,2ITZ	123631	8035066	49668	CHEMBL939	DB00317	4941		ZINC19632614	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895626	COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1	InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)	MYQAUKPBNJWPIE-UHFFFAOYSA-N	32362	5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	MUJ	4AT5	11617559	252615797				5685		ZINC13985942	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895627	CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1	InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)	CUIHSIWYWATEQL-UHFFFAOYSA-N	26474	5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10113978	56464911	71219		DB06589	5698		ZINC11617039	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895658	CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1	InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	KTUFNOKKBVMGRW-UHFFFAOYSA-N	13530	4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	STI	6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ	5291	46513933	45783	CHEMBL941	DB00619	5687		ZINC19632618	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895659	Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F	InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)	KDKUVYLMPJIGKA-UHFFFAOYSA-N	6866	1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790	5'-AMP-activated protein kinase catalytic subunit alpha-2				 1800						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	SKE	5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0	5330790	8036422		CHEMBL191003				ZINC03938688	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895660	CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1	InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)	BCFGMOOMADDAQU-UHFFFAOYSA-N	5445	CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	FMM	1XKK,3BBT	208908	8035064	49603	CHEMBL554	DB01259	5692		ZINC01550477	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895661	CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21	InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1	ZCBUQCWBWNUWSU-SFHVURJKSA-N	17055	(18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	LY4	2J2I,1UU3	153999	46517285				5263		ZINC03812168	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895662	COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1	InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)	UXXQOJXBIDBUAC-UHFFFAOYSA-N	13535	4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			3038522	46513936		CHEMBL124660	DB05465			ZINC03966243	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895663	OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1	InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)	HHFBDROWDBDFBR-UHFFFAOYSA-N	31093	4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	ZZL	2X81,5IA1,2WTW,2WTV	11712649	252615338		CHEMBL259084		5696		ZINC18825334	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895664	Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1	InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2	TUVCWJQQGGETHL-UHFFFAOYSA-N	25045	3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	X6K	2X6K,4L23,4JT6	9884685	56374189		CHEMBL538346		5701		ZINC03963016	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895666	Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1	InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)	YCOYDOIWSSHVCK-UHFFFAOYSA-N	4851	(4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			151194	8034494		CHEMBL75232CHEMBL101253	DB04879	6052		ZINC00007460	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895667	CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1	InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1	BTIHMVBBUGXLCJ-OAHLLOKOSA-N	7533	(2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	RRC	3DDQ,1YGK,2A4L,1UNL	160355	11108321		CHEMBL14762		6035		ZINC01649340	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895668	Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1	InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)	QHKYPYXTTXKZST-UHFFFAOYSA-N	13531	4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			5353940	172097219						ZINC14951176	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895669	CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1	InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)	CDMGBJANTYXAIV-UHFFFAOYSA-N	13336	4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search		1A9U,1PME,2EWA	176155	46513744		CHEMBL10		5269		ZINC96006137	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895670	NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)	FHYUGAJXYORMHI-UHFFFAOYSA-N	50110208	4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	085	3TZM	4521392	104005054		CHEMBL440084				ZINC00603769	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895671	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1	InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	MLDQJTXFUGDVEO-UHFFFAOYSA-N	16673	4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	BAX	3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF	216239	46516901	50924	CHEMBL1336	DB00398	5711		ZINC01493878	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895673	Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1	InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1	CTNPALGJUAXMMC-PMFHANACSA-N	31095	5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259	5'-AMP-activated protein kinase catalytic subunit alpha-2				 290						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10138259	252615339						ZINC18825344	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895674	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WINHZLLDWRZWRT-ATVHPVEESA-N	4814	CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248	5'-AMP-activated protein kinase catalytic subunit alpha-2				 89						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B49	6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD	5329102	8034462	38940	CHEMBL535	DB01268	5713		ZINC03964325	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895675	CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1	InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)	GCIKSSRWRFVXBI-UHFFFAOYSA-N	13534	CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide	5'-AMP-activated protein kinase catalytic subunit alpha-2				 350						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	VX6	2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN	5494449	46513935		CHEMBL572878		5718		ZINC03820040	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895676	Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1	InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H	VEPKQEUBKLEPRA-UHFFFAOYSA-N	15244	5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	52P	3ZSI,3HP5,3FC1	3038525	46515551			DB07138			ZINC13493055	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50895677	COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1	InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)	UHTHHESEBZOYNR-UHFFFAOYSA-N	21	CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361	5'-AMP-activated protein kinase catalytic subunit alpha-2				>10000						ChEMBL	10.1038/nbt1358	10.7270/Q2TT4RX2	18183025			Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP	Ambit Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	ZD6	2IVU	3081361	8030012	49960	CHEMBL24828	DB08764			ZINC03834198	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50978468	CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1	InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19)	IVYWKCAOPCHVMX-UHFFFAOYSA-N	50401152	CHEMBL2205766	5'-AMP-activated protein kinase catalytic subunit alpha-2			<10000							ChEMBL	10.1016/j.bmcl.2012.05.090	10.7270/Q2HQ412B	22726925			Sunose, M; Bell, K; Ellard, K; Bergamini, G; Neubauer, G; Werner, T; Ramsden, N	Cellzome Ltd	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50401152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50401152&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			44557921	163350176		CHEMBL2205766				ZINC95562659	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
50521687	Cc1cc(-c2ccc(\C=C3/S\C(NC3=O)=N/c3ccc(Cl)c(c3)C(O)=O)o2)c(cc1C)[N+]([O-])=O	InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10-	RTHRCOIONCZINZ-JMIUGGIZSA-N	50434272	CHEMBL1242297	5'-AMP-activated protein kinase catalytic subunit alpha-2					 12000					ChEMBL	10.1016/j.bmcl.2016.09.065	10.7270/Q25M67PH	27727125			Cameron, KO; Kurumbail, RG	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434272&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			5753734	175446589		CHEMBL1242297				ZINC13549354	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51064055	Cc1cc(-c2ccc(\C=C3/S\C(NC3=O)=N/c3ccc(Cl)c(c3)C(O)=O)o2)c(cc1C)[N+]([O-])=O	InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10-	RTHRCOIONCZINZ-JMIUGGIZSA-N	50434272	CHEMBL1242297	5'-AMP-activated protein kinase catalytic subunit alpha-2					 12000					ChEMBL	10.1021/ml400028q	10.7270/Q2Z039HW	24900695			Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ	Chinese Academy of Sciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434272&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			5753734	175446589		CHEMBL1242297				ZINC13549354	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644461	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1	InChI=1S/C53H71N9O11S/c1-68-42-11-13-46(73-41-16-22-62(23-17-41)52(66)43-12-10-39(34-56-43)51(65)57-40-14-20-61(21-15-40)35-38-8-6-37(33-54)7-9-38)44(32-42)58-49(64)18-24-69-26-28-71-30-31-72-29-27-70-25-19-55-48(63)5-3-2-4-47-50-45(36-74-47)59-53(67)60-50/h6-13,32,34,40-41,45,47,50H,2-5,14-31,35-36H2,1H3,(H,55,63)(H,57,65)(H,58,64)(H2,59,60,67)/t45-,47-,50-/m0/s1	VCUZCXZAVWJMRB-VZRKZVDPSA-N	328256	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-methoxy-2- (17-oxo-21- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10,13-tetraoxa- 16-azahenicosanamido)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 394::US9663496, Compound 394	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328256&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119971	384573183							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644462	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)28-12-4-22(18-33-28)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	PCKCBYIEMJBCQJ-UHFFFAOYSA-N	328257	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 395::US9663496, Compound 395	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328257&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710299	384573184							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644463	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O5S/c1-42(39,40)28-9-7-26(8-10-28)41-27-14-18-36(19-15-27)31(38)29-11-4-23(20-33-29)30(37)34-25-12-16-35(17-13-25)21-22-2-5-24(32)6-3-22/h2-11,20,25,27H,12-19,21H2,1H3,(H,34,37)	OLJYGJANQQAVNS-UHFFFAOYSA-N	328258	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 396	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328258&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710285	384573185							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644464	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O5S/c1-43(40,41)29-9-7-27(8-10-29)42-28-14-18-37(19-15-28)32(39)30-11-6-25(21-34-30)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,35,38)	BAMXQXRWARGWLQ-UHFFFAOYSA-N	328259	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 397	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328259&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710812	384573186							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644465	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O6S/c1-43(39,40)29-13-11-27(12-14-29)42-28-16-18-36(19-17-28)32(38)30-15-4-23(21-34-30)31(37)35-24-5-9-26(10-6-24)41-25-7-2-22(20-33)3-8-25/h2-4,7-8,11-15,21,24,26,28H,5-6,9-10,16-19H2,1H3,(H,35,37)	SJAORGIFKLUEHE-UHFFFAOYSA-N	328260	N-(4-(4-cyanophenoxy)  cyclohexyl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 398	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328260&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710668	384573187							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644466	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O5S/c1-43(40,41)27-8-6-25(7-9-27)42-26-14-18-37(19-15-26)31(39)29-11-10-28(34-35-29)30(38)33-24-12-16-36(17-13-24)21-23-4-2-22(20-32)3-5-23/h2-11,24,26H,12-19,21H2,1H3,(H,33,38)	FFDTXEQOSUMYOS-UHFFFAOYSA-N	328261	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)pyridazine-3- carboxamide::US9663496, Compound 399	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328261&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710569	384573188							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644467	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(N)cc2)CC1	InChI=1S/C32H37N5O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)29-11-6-25(20-34-29)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21,33H2,1H3,(H,35,39)	RIUDPAORZJBEQE-UHFFFAOYSA-N	328262	N-(1-(4- aminobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 400::US9663496, Compound 400	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328262&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710436	384573189							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644468	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(NC(C)=O)cc2)CC1	InChI=1S/C34H39N5O5/c1-23(40)36-28-8-3-24(4-9-28)22-38-17-15-29(16-18-38)37-33(42)27-7-12-31(35-21-27)34(43)39-19-13-26(14-20-39)32(41)25-5-10-30(44-2)11-6-25/h3-12,21,26,29H,13-20,22H2,1-2H3,(H,36,40)(H,37,42)	HVGXPVKSQJFBCU-UHFFFAOYSA-N	328263	N-(1-(4- acetamidobenzyl)  piperidin-4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 401::US9663496, Compound 401	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328263&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710516	384573190							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644469	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C32H27N5O5/c1-21(38)23-4-10-26(11-5-23)41-28-14-16-37(17-15-28)32(40)29-12-6-24(19-34-29)31(39)36-25-7-13-30(35-20-25)42-27-8-2-22(18-33)3-9-27/h2-13,19-20,28H,14-17H2,1H3,(H,36,39)	LMFALCJUULVRLB-UHFFFAOYSA-N	328264	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(4-(4-cyanophenoxy)  cyclohexyl)nicotinamide::US9663496, Compound 402	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328264&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486213	384573191							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644470	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(NC(=O)CCOCCOCCOCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)cc2)CC1	InChI=1S/C51H68N8O10S/c1-66-41-13-8-36(9-14-41)48(62)37-16-24-59(25-17-37)50(64)38-10-15-42(53-32-38)49(63)55-40-18-22-58(23-19-40)33-35-6-11-39(12-7-35)54-46(61)20-26-67-28-30-69-31-29-68-27-21-52-45(60)5-3-2-4-44-47-43(34-70-44)56-51(65)57-47/h6-15,32,37,40,43-44,47H,2-5,16-31,33-34H2,1H3,(H,52,60)(H,54,61)(H,55,63)(H2,56,57,65)/t43-,44-,47-/m0/s1	HVUHUGNDUZGZJI-NVVQJRFUSA-N	328265	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-(14-oxo-18- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10-trioxa-13- azaoctadecanamido)  benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 403::US9663496, Compound 403	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328265&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119942	384573192							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644471	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(CC2)c2ccc(F)cc2)cc1	InChI=1S/C29H31F2N5O2/c30-23-4-1-21(2-5-23)20-34-15-17-36(18-16-34)29(38)27-10-3-22(19-32-27)28(37)33-25-11-13-35(14-12-25)26-8-6-24(31)7-9-26/h1-10,19,25H,11-18,20H2,(H,33,37)	VGOONDYBJSKCBN-UHFFFAOYSA-N	328266	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluorophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 404::US9663496, Compound 404	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328266&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710412	384573193							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644472	COc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H34FN5O3/c1-39-27-9-7-26(8-10-27)35-14-12-25(13-15-35)33-29(37)23-4-11-28(32-20-23)30(38)36-18-16-34(17-19-36)21-22-2-5-24(31)6-3-22/h2-11,20,25H,12-19,21H2,1H3,(H,33,37)	FKSSSDMQVIYXCQ-UHFFFAOYSA-N	328267	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxyphenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 405::US9663496, Compound 405	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328267&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710479	384573194							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644473	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H36FN5O4/c1-22(39)35-26-7-9-28(10-8-26)42-29-14-18-38(19-15-29)32(41)30-11-4-24(20-34-30)31(40)36-27-12-16-37(17-13-27)21-23-2-5-25(33)6-3-23/h2-11,20,27,29H,12-19,21H2,1H3,(H,35,39)(H,36,40)	YQMZZWAQXKEZOB-UHFFFAOYSA-N	328268	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 406::US9663496, Compound 406	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328268&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710323	384573195							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644474	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(NC(C)=O)cc2)cc1	InChI=1S/C33H39N5O5/c1-23(39)35-26-6-10-29(11-7-26)43-30-15-19-38(20-16-30)33(41)31-12-5-25(21-34-31)32(40)36-27-13-17-37(18-14-27)22-24-3-8-28(42-2)9-4-24/h3-12,21,27,30H,13-20,22H2,1-2H3,(H,35,39)(H,36,40)	XYVPQYHJOMNWFW-UHFFFAOYSA-N	328269	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 407::US9663496, Compound 407	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328269&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710478	384573196							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644475	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H28FN5O5/c1-20(38)35-23-5-10-25(11-6-23)41-27-14-16-37(17-15-27)31(40)21-2-12-28(33-18-21)30(39)36-24-7-13-29(34-19-24)42-26-8-3-22(32)4-9-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)(H,36,39)	CZJQSTWTDOMTMC-UHFFFAOYSA-N	328270	5-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 408::US9663496, Compound 408	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328270&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710378	384573197							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644476	O=C(Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1)C1CC1	InChI=1S/C35H38N6O4/c36-21-24-1-3-25(4-2-24)23-40-17-13-29(14-18-40)39-34(43)27-7-12-32(37-22-27)35(44)41-19-15-31(16-20-41)45-30-10-8-28(9-11-30)38-33(42)26-5-6-26/h1-4,7-12,22,26,29,31H,5-6,13-20,23H2,(H,38,42)(H,39,43)	MPYZAJHIMPJCAB-UHFFFAOYSA-N	328271	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropane- carboxamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 409::US9663496, Compound 409	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328271&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710456	384573198							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644477	FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O3S/c33-32(34,35)44-28-8-6-26(7-9-28)43-27-13-17-40(18-14-27)31(42)24-5-10-29(37-20-24)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	CUGRGOQWDRJFLR-UHFFFAOYSA-N	328272	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylthio)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 410::US9663496, Compound 410	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328272&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710755	384573199							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644478	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C33H36N6O4/c1-23(40)36-28-3-2-4-30(19-28)43-29-13-17-39(18-14-29)33(42)31-10-9-26(21-35-31)32(41)37-27-11-15-38(16-12-27)22-25-7-5-24(20-34)6-8-25/h2-10,19,21,27,29H,11-18,22H2,1H3,(H,36,40)(H,37,41)	YBCMWZLNHLQBTF-UHFFFAOYSA-N	328273	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 411::US9663496, Compound 411	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328273	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328273&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710618	384573200							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644479	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(C)=O)c2)cc1	InChI=1S/C33H39N5O5/c1-23(39)35-27-4-3-5-30(20-27)43-29-14-18-38(19-15-29)33(41)31-11-8-25(21-34-31)32(40)36-26-12-16-37(17-13-26)22-24-6-9-28(42-2)10-7-24/h3-11,20-21,26,29H,12-19,22H2,1-2H3,(H,35,39)(H,36,40)	UFIJHORMJXQIKW-UHFFFAOYSA-N	328274	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 412::US9663496, Compound 412	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328274	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328274&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710399	384573201							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644480	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)c1	InChI=1S/C32H36FN5O4/c1-22(39)35-27-3-2-4-29(19-27)42-28-13-17-38(18-14-28)32(41)30-10-7-24(20-34-30)31(40)36-26-11-15-37(16-12-26)21-23-5-8-25(33)9-6-23/h2-10,19-20,26,28H,11-18,21H2,1H3,(H,35,39)(H,36,40)	QAQJNUIVHQIXNU-UHFFFAOYSA-N	328275	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 413::US9663496, Compound 413	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328275	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328275&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710376	384573202							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644481	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)c1	InChI=1S/C31H28FN5O5/c1-20(38)35-23-3-2-4-27(17-23)41-26-13-15-37(16-14-26)31(40)28-11-5-21(18-33-28)30(39)36-24-8-12-29(34-19-24)42-25-9-6-22(32)7-10-25/h2-12,17-19,26H,13-16H2,1H3,(H,35,38)(H,36,39)	HFTJORLORZXKEZ-UHFFFAOYSA-N	328276	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 414::US9663496, Compound 414	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328276&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710707	384573203							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644482	FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)24-5-10-29(37-20-24)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	LUSWURPIWQNHMX-UHFFFAOYSA-N	328277	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 415::US9663496, Compound 415	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328277&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710397	384573204							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644483	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ncc(cc1CCCNC(=O)OC(C)(C)C)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C41H50N6O6/c1-41(2,3)53-40(51)43-19-5-6-32-24-33(38(49)45-34-17-20-46(21-18-34)27-29-9-7-28(25-42)8-10-29)26-44-36(32)39(50)47-22-15-31(16-23-47)37(48)30-11-13-35(52-4)14-12-30/h7-14,24,26,31,34H,5-6,15-23,27H2,1-4H3,(H,43,51)(H,45,49)	UUICOLGNKPZDCW-UHFFFAOYSA-N	328278	US10377742, Compound 416::US9663496, Compound 416::tert-butyl 3-(5-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-2-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyridin-3- yl)propylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328278&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710588	384573205							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644484	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(CC2)c2ccc(cc2)C#N)cc1	InChI=1S/C30H31FN6O2/c31-25-6-1-23(2-7-25)21-35-15-17-37(18-16-35)30(39)28-10-5-24(20-33-28)29(38)34-26-11-13-36(14-12-26)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)	MHLHQNWCMLCICH-UHFFFAOYSA-N	328279	N-(1-(4- cyanophenyl)piperidin- 4-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 417::US9663496, Compound 417	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328279&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710325	384573206							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644485	O=C(NC1CCN(CC1)c1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H30N6O3/c32-19-22-1-6-26(7-2-22)36-15-11-25(12-16-36)35-30(38)24-5-10-29(34-21-24)31(39)37-17-13-28(14-18-37)40-27-8-3-23(20-33)4-9-27/h1-10,21,25,28H,11-18H2,(H,35,38)	AMGOYODSYQCBIL-UHFFFAOYSA-N	328280	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 418::US9663496, Compound 418	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328280&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710612	384573207							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644486	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1cccs1	InChI=1S/C30H31N5O3S/c31-18-21-3-5-22(6-4-21)20-34-13-11-25(12-14-34)33-29(37)26-8-7-24(19-32-26)30(38)35-15-9-23(10-16-35)28(36)27-2-1-17-39-27/h1-8,17,19,23,25H,9-16,20H2,(H,33,37)	HIVBNBYETREPDI-UHFFFAOYSA-N	328281	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(thiophene-2- carbonyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 419::US9663496, Compound 419	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328281&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710774	384573208							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644487	CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H33N5O5S/c1-42(39,40)28-9-5-25(6-10-28)35-16-12-24(13-17-35)34-30(37)23-4-11-29(33-21-23)31(38)36-18-14-27(15-19-36)41-26-7-2-22(20-32)3-8-26/h2-11,21,24,27H,12-19H2,1H3,(H,34,37)	RWRQJVGLXNKXAI-UHFFFAOYSA-N	328282	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)phenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 420::US9663496, Compound 420	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328282&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710859	384573209							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644488	CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(F)cc1	InChI=1S/C30H33FN4O5S/c1-41(38,39)27-9-5-24(6-10-27)34-16-12-23(13-17-34)33-29(36)21-2-11-28(32-20-21)30(37)35-18-14-26(15-19-35)40-25-7-3-22(31)4-8-25/h2-11,20,23,26H,12-19H2,1H3,(H,33,36)	IZSFSMTTYFZCDP-UHFFFAOYSA-N	328283	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- (methylsulfonyl)phenyl)  piperidin-4- yl)nicotinamide::US9663496, Compound 421	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328283	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328283&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486214	384573210							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644489	Fc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C30H30FN5O3/c31-23-4-6-25(7-5-23)35-15-11-24(12-16-35)34-29(37)22-3-10-28(33-20-22)30(38)36-17-13-27(14-18-36)39-26-8-1-21(19-32)2-9-26/h1-10,20,24,27H,11-18H2,(H,34,37)	HLZSPWLRXQTEHF-UHFFFAOYSA-N	328284	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 422::US9663496, Compound 422	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328284&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710510	384573211							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644490	COc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H33N5O4/c1-39-26-9-5-25(6-10-26)35-16-12-24(13-17-35)34-30(37)23-4-11-29(33-21-23)31(38)36-18-14-28(15-19-36)40-27-7-2-22(20-32)3-8-27/h2-11,21,24,28H,12-19H2,1H3,(H,34,37)	XDHLQPZDWFLLBX-UHFFFAOYSA-N	328285	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxyphenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 423::US9663496, Compound 423	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328285&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710327	384573212							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644491	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cccc(OC(F)(F)F)c2)CC1	InChI=1S/C33H35F3N4O5/c1-44-27-8-5-23(6-9-27)30(41)24-11-17-40(18-12-24)32(43)29-10-7-25(20-37-29)31(42)38-26-13-15-39(16-14-26)21-22-3-2-4-28(19-22)45-33(34,35)36/h2-10,19-20,24,26H,11-18,21H2,1H3,(H,38,42)	DRTNBWSDTRSDFI-UHFFFAOYSA-N	328286	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 424::US9663496, Compound 424	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328286&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710273	384573213							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644492	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cccc(OC)c2)CC1	InChI=1S/C33H38N4O5/c1-41-28-9-6-24(7-10-28)31(38)25-12-18-37(19-13-25)33(40)30-11-8-26(21-34-30)32(39)35-27-14-16-36(17-15-27)22-23-4-3-5-29(20-23)42-2/h3-11,20-21,25,27H,12-19,22H2,1-2H3,(H,35,39)	FIFRYWRXSPZTJD-UHFFFAOYSA-N	328287	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(3-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 425::US9663496, Compound 425	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328287&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710603	384573214							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644493	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cc(C)on2)C[C@@H]1F	InChI=1S/C30H34FN5O5/c1-19-15-23(34-41-19)17-35-12-11-26(25(31)18-35)33-29(38)22-5-8-27(32-16-22)30(39)36-13-9-21(10-14-36)28(37)20-3-6-24(40-2)7-4-20/h3-8,15-16,21,25-26H,9-14,17-18H2,1-2H3,(H,33,38)/t25-,26?/m0/s1	HJLLFICFQXAIAT-PMCHYTPCSA-N	328288	N-((3S,4R)-3-fluoro-1- ((5-methylisoxazol-3- yl)methyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 426	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328288	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328288&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486215	384573215							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644494	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2csc(C)n2)C[C@@H]1F	InChI=1S/C30H34FN5O4S/c1-19-33-23(18-41-19)16-35-12-11-26(25(31)17-35)34-29(38)22-5-8-27(32-15-22)30(39)36-13-9-21(10-14-36)28(37)20-3-6-24(40-2)7-4-20/h3-8,15,18,21,25-26H,9-14,16-17H2,1-2H3,(H,34,38)/t25-,26?/m0/s1	QECRHJAQOQEILO-PMCHYTPCSA-N	328289	N-((3S,4R)-3-fluoro-1- ((2-methylthiazol-4- yl)methyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 427	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328289&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486216	384573216							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644495	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C33H36F3N5O5/c1-22(42)38-25-6-8-27(9-7-25)45-28-13-17-41(18-14-28)32(44)30-10-5-24(20-37-30)31(43)39-26-11-15-40(16-12-26)21-23-3-2-4-29(19-23)46-33(34,35)36/h2-10,19-20,26,28H,11-18,21H2,1H3,(H,38,42)(H,39,43)	NXUARYUTSSUSSG-UHFFFAOYSA-N	328290	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 428::US9663496, Compound 428	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328290&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710593	384573217							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644496	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c1	InChI=1S/C33H36F3N5O5/c1-22(42)38-26-5-3-6-28(19-26)45-27-12-16-41(17-13-27)32(44)30-9-8-24(20-37-30)31(43)39-25-10-14-40(15-11-25)21-23-4-2-7-29(18-23)46-33(34,35)36/h2-9,18-20,25,27H,10-17,21H2,1H3,(H,38,42)(H,39,43)	HJAZSWLXYPIMTM-UHFFFAOYSA-N	328291	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 429::US9663496, Compound 429	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328291&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710419	384573218							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644497	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C33H35F3N4O5/c1-44-27-9-4-23(5-10-27)30(41)24-12-18-40(19-13-24)32(43)29-11-6-25(20-37-29)31(42)38-26-14-16-39(17-15-26)21-22-2-7-28(8-3-22)45-33(34,35)36/h2-11,20,24,26H,12-19,21H2,1H3,(H,38,42)	ZWIGVNWZHBPXNS-UHFFFAOYSA-N	328292	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 430::US9663496, Compound 430	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328292&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710324	384573219							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644498	O=C(Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1)C1CC1	InChI=1S/C35H38N6O4/c36-21-24-4-6-25(7-5-24)23-40-16-12-28(13-17-40)38-34(43)27-10-11-32(37-22-27)35(44)41-18-14-30(15-19-41)45-31-3-1-2-29(20-31)39-33(42)26-8-9-26/h1-7,10-11,20,22,26,28,30H,8-9,12-19,23H2,(H,38,43)(H,39,42)	HWRKUDAALZUHQC-UHFFFAOYSA-N	328293	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(cyclopropane- carboxamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 431::US9663496, Compound 431	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328293&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710338	384573220							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644499	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C34H38FN5O4/c35-26-9-4-23(5-10-26)22-39-16-12-27(13-17-39)37-33(42)25-8-11-31(36-21-25)34(43)40-18-14-29(15-19-40)44-30-3-1-2-28(20-30)38-32(41)24-6-7-24/h1-5,8-11,20-21,24,27,29H,6-7,12-19,22H2,(H,37,42)(H,38,41)	QSFYVVXENQIVBX-UHFFFAOYSA-N	328294	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 432::US9663496, Compound 432	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328294&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710656	384573221							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644500	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3cccc(NC(=O)C4CC4)c3)cn2)cc1	InChI=1S/C33H30FN5O5/c34-23-7-10-26(11-8-23)44-30-13-9-25(20-36-30)38-32(41)22-6-12-29(35-19-22)33(42)39-16-14-27(15-17-39)43-28-3-1-2-24(18-28)37-31(40)21-4-5-21/h1-3,6-13,18-21,27H,4-5,14-17H2,(H,37,40)(H,38,41)	QGTOSURPTIGUOB-UHFFFAOYSA-N	328295	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 433::US9663496, Compound 433	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328295&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710484	384573222							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644501	O=C(Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CC[C@@H](CC2)Oc2ccc(cc2)C#N)c1)C1CC1	InChI=1S/C35H37N5O5/c36-21-23-4-11-28(12-5-23)44-29-13-9-26(10-14-29)38-34(42)25-8-15-32(37-22-25)35(43)40-18-16-30(17-19-40)45-31-3-1-2-27(20-31)39-33(41)24-6-7-24/h1-5,8,11-12,15,20,22,24,26,29-30H,6-7,9-10,13-14,16-19H2,(H,38,42)(H,39,41)/t26?,29-	JKWVHOJBLXODFV-MXLLDWDMSA-N	328296	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-6-(4-(3- (cyclopropane- carboxamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 434	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328296	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328296&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710583	384573223							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644502	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C35H41N5O5/c1-44-29-10-5-24(6-11-29)23-39-17-13-27(14-18-39)37-34(42)26-9-12-32(36-22-26)35(43)40-19-15-30(16-20-40)45-31-4-2-3-28(21-31)38-33(41)25-7-8-25/h2-6,9-12,21-22,25,27,30H,7-8,13-20,23H2,1H3,(H,37,42)(H,38,41)	OUBRCHVVTYPJMB-UHFFFAOYSA-N	328297	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 435::US9663496, Compound 435	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328297&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710433	384573224							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644503	FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H31F3N6O3S/c32-31(33,34)44-26-7-5-24(6-8-26)43-25-13-17-40(18-14-25)30(42)28-10-9-27(37-38-28)29(41)36-23-11-15-39(16-12-23)20-22-3-1-21(19-35)2-4-22/h1-10,23,25H,11-18,20H2,(H,36,41)	PKZHINNMONLOBK-UHFFFAOYSA-N	328298	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethylthio)  phenoxy)piperidine-1- carbonyl)pyridazine-3- carboxamide::US10377742, Compound 436::US9663496, Compound 436	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328298&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710813	384573225							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644504	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34N6O4/c1-22(39)25-6-8-27(9-7-25)42-28-14-18-38(19-15-28)32(41)30-11-10-29(35-36-30)31(40)34-26-12-16-37(17-13-26)21-24-4-2-23(20-33)3-5-24/h2-11,26,28H,12-19,21H2,1H3,(H,34,40)	ACJLYGUYLHGBRM-UHFFFAOYSA-N	328299	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)pyridazine-3- carboxamide::US10377742, Compound 437::US9663496, Compound 437	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328299&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710739	384573226							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644505	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C35H38F3N5O5/c36-35(37,38)48-29-9-4-23(5-10-29)22-42-16-12-26(13-17-42)40-33(45)25-8-11-31(39-21-25)34(46)43-18-14-28(15-19-43)47-30-3-1-2-27(20-30)41-32(44)24-6-7-24/h1-5,8-11,20-21,24,26,28H,6-7,12-19,22H2,(H,40,45)(H,41,44)	ZEJJGUPFZSMWAX-UHFFFAOYSA-N	328300	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 438::US9663496, Compound 438	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328300&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710754	384573227							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644506	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C36H43N5O4/c1-45-32-11-4-26(5-12-32)25-39-20-16-30(17-21-39)38-35(43)29-8-13-33(37-24-29)36(44)41-22-14-28(15-23-41)34(42)27-6-9-31(10-7-27)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	LLRSNVNZYTWKPN-UHFFFAOYSA-N	328301	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 439::US9663496, Compound 439	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328301&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710531	384573228							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644507	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-10-3-25(4-11-31)24-42-19-15-29(16-20-42)41-34(46)28-7-12-32(40-23-28)35(47)44-21-13-27(14-22-44)33(45)26-5-8-30(9-6-26)43-17-1-2-18-43/h3-12,23,27,29H,1-2,13-22,24H2,(H,41,46)	CYFFRIPWULCMAW-UHFFFAOYSA-N	328302	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 440::US9663496, Compound 440	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328302&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710384	384573229							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644508	FC(F)(F)Oc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)c1	InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-5-3-4-25(22-31)24-42-18-14-29(15-19-42)41-34(46)28-8-11-32(40-23-28)35(47)44-20-12-27(13-21-44)33(45)26-6-9-30(10-7-26)43-16-1-2-17-43/h3-11,22-23,27,29H,1-2,12-21,24H2,(H,41,46)	IRZRWLCHLOQQMF-UHFFFAOYSA-N	328303	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 441::US9663496, Compound 441	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328303&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710467	384573230							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644509	O=C(NC1CC[C@@H](CC1)Oc1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C36H39N5O4/c37-23-25-3-12-31(13-4-25)45-32-14-8-29(9-15-32)39-35(43)28-7-16-33(38-24-28)36(44)41-21-17-27(18-22-41)34(42)26-5-10-30(11-6-26)40-19-1-2-20-40/h3-7,10-13,16,24,27,29,32H,1-2,8-9,14-15,17-22H2,(H,39,43)/t29?,32-	PWNFGRQMNJTNJN-MDFPRCSVSA-N	328304	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 442	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328304	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328304&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710659	384573231							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644510	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1F	InChI=1S/C36H42FN5O4/c1-46-33-11-4-25(22-31(33)37)24-40-18-14-29(15-19-40)39-35(44)28-7-10-32(38-23-28)36(45)42-20-12-27(13-21-42)34(43)26-5-8-30(9-6-26)41-16-2-3-17-41/h4-11,22-23,27,29H,2-3,12-21,24H2,1H3,(H,39,44)	FKPPDDDQZXPHNG-UHFFFAOYSA-N	328305	N-(1-(3-fluoro-4- methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 443::US9663496, Compound 443	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328305	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328305&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710480	384573232							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644511	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C39H48N6O3/c46-37(30-7-12-35(13-8-30)44-21-3-4-22-44)31-15-25-45(26-16-31)39(48)36-14-9-32(27-40-36)38(47)41-33-17-23-42(24-18-33)28-29-5-10-34(11-6-29)43-19-1-2-20-43/h5-14,27,31,33H,1-4,15-26,28H2,(H,41,47)	GTYRGADELCISQB-UHFFFAOYSA-N	328306	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 444::US9663496, Compound 444	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328306&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710698	384573233							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644512	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCNCC1	InChI=1S/C25H30N4O4/c1-33-21-5-2-17(3-6-21)23(30)18-10-14-29(15-11-18)25(32)22-7-4-19(16-27-22)24(31)28-20-8-12-26-13-9-20/h2-7,16,18,20,26H,8-15H2,1H3,(H,28,31)	JEZQAPKFUPHGQX-UHFFFAOYSA-N	328307	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(piperidin-4- yl)nicotinamide::US10377742, Compound 445::US9663496, Compound 445	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328307&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710471	384573234							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644513	CC(C)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C38H47N5O4/c1-27(2)47-34-12-5-28(6-13-34)26-41-21-17-32(18-22-41)40-37(45)31-9-14-35(39-25-31)38(46)43-23-15-30(16-24-43)36(44)29-7-10-33(11-8-29)42-19-3-4-20-42/h5-14,25,27,30,32H,3-4,15-24,26H2,1-2H3,(H,40,45)	HUMCBAOVNNNRNA-UHFFFAOYSA-N	328308	N-(1-(4- isopropoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 446::US9663496, Compound 446	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328308	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328308&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710454	384573235							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644514	Fc1cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)ccc1C#N	InChI=1S/C36H39FN6O3/c37-32-21-25(3-4-28(32)22-38)24-41-17-13-30(14-18-41)40-35(45)29-7-10-33(39-23-29)36(46)43-19-11-27(12-20-43)34(44)26-5-8-31(9-6-26)42-15-1-2-16-42/h3-10,21,23,27,30H,1-2,11-20,24H2,(H,40,45)	LQGICZMHJVYZGC-UHFFFAOYSA-N	328309	N-(1-(4-cyano-3- fluorobenzyl)piperidin- 4-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 447::US9663496, Compound 447	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328309&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710475	384573236							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644515	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(NS(=O)(=O)C2CC2)cc1	InChI=1S/C34H38N6O5S/c35-21-24-1-3-25(4-2-24)23-39-17-13-27(14-18-39)37-33(41)26-5-12-32(36-22-26)34(42)40-19-15-30(16-20-40)45-29-8-6-28(7-9-29)38-46(43,44)31-10-11-31/h1-9,12,22,27,30-31,38H,10-11,13-20,23H2,(H,37,41)	CLJBRWCXTFMREC-UHFFFAOYSA-N	328310	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropane- sulfonamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 448::US9663496, Compound 448	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328310&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710476	384573237							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644516	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(NS(=O)(=O)C4CC4)cc3)cn2)cc1	InChI=1S/C32H30FN5O6S/c33-22-2-7-26(8-3-22)44-30-14-6-24(20-35-30)36-31(39)21-1-13-29(34-19-21)32(40)38-17-15-27(16-18-38)43-25-9-4-23(5-10-25)37-45(41,42)28-11-12-28/h1-10,13-14,19-20,27-28,37H,11-12,15-18H2,(H,36,39)	WYUCTYJNLHAUHO-UHFFFAOYSA-N	328311	6-(4-(4-(cyclopropane- sulfonamido)phenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 449::US9663496, Compound 449	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328311	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328311&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710599	384573238							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644517	FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)29-10-5-24(20-37-29)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	XVUVHIMZDREIIH-UHFFFAOYSA-N	328312	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 450::US9663496, Compound 450	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328312&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710750	384573239							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644518	F[C@@H]1CN(Cc2ccc(cc2)C#N)CCC1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C(F)(F)F	InChI=1S/C32H31F4N5O5S/c33-27-20-40(19-22-3-1-21(17-37)2-4-22)14-13-28(27)39-30(42)23-5-10-29(38-18-23)31(43)41-15-11-25(12-16-41)46-24-6-8-26(9-7-24)47(44,45)32(34,35)36/h1-10,18,25,27-28H,11-16,19-20H2,(H,39,42)/t27-,28?/m1/s1	BFKLKEDGPVUXEU-QXPUDEPPSA-N	328313	N-((trans)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4- (trifluoromethylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 451	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328313	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328313&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084295	384573240							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644519	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m1/s1	LEUSDRGCPVXECX-FQLXRVMXSA-N	328314	N-((3R,4R)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 452::US9663496, Compound 452	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328314&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652376	384573241							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644520	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m0/s1	LEUSDRGCPVXECX-VMPREFPWSA-N	328315	N-((3S,4S)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 453::US9663496, Compound 453	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328315	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328315&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652377	384573242							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644521	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)C[C@@H]2F)cc1	InChI=1S/C32H34FN5O4/c1-41-25-7-9-26(10-8-25)42-27-12-16-38(17-13-27)32(40)30-11-6-24(19-35-30)31(39)36-29-14-15-37(21-28(29)33)20-23-4-2-22(18-34)3-5-23/h2-11,19,27-29H,12-17,20-21H2,1H3,(H,36,39)/t28-,29?/m0/s1	GUFOLFDCFADZOS-XLTVJXRZSA-N	328316	N-((cis)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 454	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328316	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328316&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486217	384573243							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644522	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1	InChI=1S/C35H37F3N4O5/c36-35(37,38)47-30-8-1-23(2-9-30)22-41-17-13-27(14-18-41)40-33(44)26-7-12-31(39-21-26)34(45)42-19-15-29(16-20-42)46-28-10-5-25(6-11-28)32(43)24-3-4-24/h1-2,5-12,21,24,27,29H,3-4,13-20,22H2,(H,40,44)	VUYRMWJLJSPEAR-UHFFFAOYSA-N	328317	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 455::US9663496, Compound 455	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328317	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328317&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710635	384573244							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644523	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C(=O)C1CC1	InChI=1S/C35H37N5O4/c36-21-24-1-3-25(4-2-24)23-39-17-13-29(14-18-39)38-34(42)28-9-12-32(37-22-28)35(43)40-19-15-31(16-20-40)44-30-10-7-27(8-11-30)33(41)26-5-6-26/h1-4,7-12,22,26,29,31H,5-6,13-20,23H2,(H,38,42)	RSAGGDQJRANTFF-UHFFFAOYSA-N	328318	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 456::US9663496, Compound 456	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328318	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328318&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710518	384573245							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644524	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C(=O)C3CC3)cn2)cc1	InChI=1S/C33H29FN4O5/c34-24-6-11-27(12-7-24)43-30-14-8-25(20-36-30)37-32(40)23-5-13-29(35-19-23)33(41)38-17-15-28(16-18-38)42-26-9-3-22(4-10-26)31(39)21-1-2-21/h3-14,19-21,28H,1-2,15-18H2,(H,37,40)	YWDIAISASAOPKH-UHFFFAOYSA-N	328319	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 457::US9663496, Compound 457	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328319&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710580	384573246							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644525	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1	InChI=1S/C35H40N4O5/c1-43-29-9-2-24(3-10-29)23-38-18-14-28(15-19-38)37-34(41)27-8-13-32(36-22-27)35(42)39-20-16-31(17-21-39)44-30-11-6-26(7-12-30)33(40)25-4-5-25/h2-3,6-13,22,25,28,31H,4-5,14-21,23H2,1H3,(H,37,41)	KHGJLNGHJFLLLE-UHFFFAOYSA-N	328320	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 458::US9663496, Compound 458	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328320&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710705	384573247							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644526	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C31H27N5O6S/c1-43(39,40)27-10-8-24(9-11-27)41-26-14-16-36(17-15-26)31(38)28-12-4-22(19-33-28)30(37)35-23-5-13-29(34-20-23)42-25-6-2-21(18-32)3-7-25/h2-13,19-20,26H,14-17H2,1H3,(H,35,37)	ZZTBEWMJLPGORM-UHFFFAOYSA-N	328321	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 459::US9663496, Compound 459	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328321&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710354	384573248							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644527	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1	InChI=1S/C32H27N5O5/c1-41-26-10-4-22(5-11-26)30(38)23-14-16-37(17-15-23)32(40)28-12-6-24(19-34-28)31(39)36-25-7-13-29(35-20-25)42-27-8-2-21(18-33)3-9-27/h2-13,19-20,23H,14-17H2,1H3,(H,36,39)	NMTSURTYCYXFAT-UHFFFAOYSA-N	328322	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 460::US9663496, Compound 460	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328322&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710330	384573249							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644528	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@@H]1F	InChI=1S/C33H34F4N4O5/c1-45-25-9-4-22(5-10-25)30(42)23-12-16-41(17-13-23)32(44)29-11-6-24(18-38-29)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-26(8-3-21)46-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28?/m0/s1	HWOSDYNCBXZMQP-MBMZGMDYSA-N	328323	N-((cis)-3-fluoro-1-(4- (trifluoromethoxy)  benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 461	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328323&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486218	384573250							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644529	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(C)=O)nc1	InChI=1S/C33H30N4O6/c1-21(38)22-3-11-28(12-4-22)43-30-14-8-26(20-35-30)36-32(40)25-7-13-29(34-19-25)33(41)37-17-15-24(16-18-37)31(39)23-5-9-27(42-2)10-6-23/h3-14,19-20,24H,15-18H2,1-2H3,(H,36,40)	GVYSRPMXFBVISQ-UHFFFAOYSA-N	328324	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 462::US9663496, Compound 462	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328324&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710437	384573251							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644530	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)c(F)c1	InChI=1S/C31H23F2N5O4/c32-22-4-8-25(26(33)15-22)29(39)20-11-13-38(14-12-20)31(41)27-9-3-21(17-35-27)30(40)37-23-5-10-28(36-18-23)42-24-6-1-19(16-34)2-7-24/h1-10,15,17-18,20H,11-14H2,(H,37,40)	MBGUZCQMFZFQCG-UHFFFAOYSA-N	328325	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 463::US9663496, Compound 463	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328325&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710502	384573252							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644531	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C32H26F2N4O5/c1-19(39)20-2-7-25(8-3-20)43-29-11-6-24(18-36-29)37-31(41)22-4-10-28(35-17-22)32(42)38-14-12-21(13-15-38)30(40)26-9-5-23(33)16-27(26)34/h2-11,16-18,21H,12-15H2,1H3,(H,37,41)	GKRIJBBPXCVYRF-UHFFFAOYSA-N	328326	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 464::US9663496, Compound 464	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328326&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710457	384573253							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644532	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)S(C)(=O)=O)nc1	InChI=1S/C32H30N4O7S/c1-42-25-7-3-21(4-8-25)30(37)22-15-17-36(18-16-22)32(39)28-13-5-23(19-33-28)31(38)35-24-6-14-29(34-20-24)43-26-9-11-27(12-10-26)44(2,40)41/h3-14,19-20,22H,15-18H2,1-2H3,(H,35,38)	WWMWPFIHGSDSJL-UHFFFAOYSA-N	328327	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(6-(4-(methylsulfonyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 465::US9663496, Compound 465	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328327&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710641	384573254							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644533	CS(=O)(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C31H26F2N4O6S/c1-44(41,42)24-7-5-23(6-8-24)43-28-11-4-22(18-35-28)36-30(39)20-2-10-27(34-17-20)31(40)37-14-12-19(13-15-37)29(38)25-9-3-21(32)16-26(25)33/h2-11,16-19H,12-15H2,1H3,(H,36,39)	YJVUDJAYUHJDRZ-UHFFFAOYSA-N	328328	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4-(methylsulfonyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 466::US9663496, Compound 466	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328328&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710342	384573255							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644534	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(nc1)S(=O)(=O)c1ccc(F)cc1	InChI=1S/C31H27FN4O6S/c1-42-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)27-12-4-22(18-33-27)30(38)35-24-7-13-28(34-19-24)43(40,41)26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	HSERFCLBNQCVPF-UHFFFAOYSA-N	328329	N-(6-(4- fluorophenylsulfonyl)  pyridin-3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 467::US9663496, Compound 467	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328329&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710512	384573256							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644535	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)cn1	InChI=1S/C32H27N5O5/c1-41-25-9-4-22(5-10-25)30(38)23-14-16-37(17-15-23)32(40)28-12-6-24(19-34-28)31(39)36-29-13-11-27(20-35-29)42-26-7-2-21(18-33)3-8-26/h2-13,19-20,23H,14-17H2,1H3,(H,35,36,39)	MHVPPJHUAXVIGF-UHFFFAOYSA-N	328330	N-(5-(4- cyanophenoxy)pyridin- 2-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 468::US9663496, Compound 468	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328330&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710779	384573257							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644536	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)cn2)c(F)c1	InChI=1S/C31H23F2N5O4/c32-22-4-8-25(26(33)15-22)29(39)20-11-13-38(14-12-20)31(41)27-9-3-21(17-35-27)30(40)37-28-10-7-24(18-36-28)42-23-5-1-19(16-34)2-6-23/h1-10,15,17-18,20H,11-14H2,(H,36,37,40)	OWQAWPLCNSFMKM-UHFFFAOYSA-N	328331	N-(5-(4- cyanophenoxy)pyridin- 2-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 469::US9663496, Compound 469	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328331&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710425	384573258							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644537	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C31H32F4N4O5S/c32-23-4-8-26(9-5-23)45(42,43)27-13-17-39(18-14-27)30(41)28-10-3-22(19-36-28)29(40)37-24-11-15-38(16-12-24)20-21-1-6-25(7-2-21)44-31(33,34)35/h1-10,19,24,27H,11-18,20H2,(H,37,40)	KCEAIMNCDQJEOH-UHFFFAOYSA-N	328332	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 470::US9663496, Compound 470	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328332&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710597	384573259							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644538	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32FN5O4S/c32-25-6-8-27(9-7-25)42(40,41)28-13-17-37(18-14-28)31(39)29-10-5-24(20-34-29)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-33)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,35,38)	JZZXYUGABUNNTJ-UHFFFAOYSA-N	328333	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 471::US9663496, Compound 471	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328333&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710702	384573260							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644539	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1	InChI=1S/C30H24FN5O5S/c31-22-4-9-25(10-5-22)42(39,40)26-13-15-36(16-14-26)30(38)27-11-3-21(18-33-27)29(37)35-23-6-12-28(34-19-23)41-24-7-1-20(17-32)2-8-24/h1-12,18-19,26H,13-16H2,(H,35,37)	ZPVFVTXUAVUJPB-UHFFFAOYSA-N	328334	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 472::US9663496, Compound 472	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328334&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710808	384573261							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644540	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)S(=O)(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C31H27FN4O6S/c1-20(37)21-2-8-25(9-3-21)42-29-13-7-24(19-34-29)35-30(38)22-4-12-28(33-18-22)31(39)36-16-14-27(15-17-36)43(40,41)26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	NWALXLHJGKSUHI-UHFFFAOYSA-N	328335	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 473::US9663496, Compound 473	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328335&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710515	384573262							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644541	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)S(=O)(=O)c2ccc(F)cc2)cc1	InChI=1S/C31H35FN4O5S/c1-41-26-7-2-22(3-8-26)21-35-16-12-25(13-17-35)34-30(37)23-4-11-29(33-20-23)31(38)36-18-14-28(15-19-36)42(39,40)27-9-5-24(32)6-10-27/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	JRJGDHLBBROFNB-UHFFFAOYSA-N	328336	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 474::US9663496, Compound 474	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328336&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710632	384573263							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644542	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)S(=O)(=O)c2ccc(F)cc2)c1	InChI=1S/C31H35FN4O5S/c1-41-26-4-2-3-22(19-26)21-35-15-11-25(12-16-35)34-30(37)23-5-10-29(33-20-23)31(38)36-17-13-28(14-18-36)42(39,40)27-8-6-24(32)7-9-27/h2-10,19-20,25,28H,11-18,21H2,1H3,(H,34,37)	DMPDJUBALZCJMN-UHFFFAOYSA-N	328337	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(3-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 475::US9663496, Compound 475	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328337	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328337&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710592	384573264							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644543	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-6-1-22(2-7-24)20-36-13-15-37(16-14-36)30(39)27-11-5-23(18-33-27)29(38)35-25-8-12-28(34-19-25)40-26-9-3-21(17-32)4-10-26/h1-12,18-19H,13-16,20H2,(H,35,38)	LFRYTBJZABLZSQ-UHFFFAOYSA-N	328338	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 476::US9663496, Compound 476	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328338	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328338&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710556	384573265							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644544	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cn2)cc1	InChI=1S/C31H28FN5O4/c1-21(38)23-4-10-27(11-5-23)41-29-13-9-26(19-34-29)35-30(39)24-6-12-28(33-18-24)31(40)37-16-14-36(15-17-37)20-22-2-7-25(32)8-3-22/h2-13,18-19H,14-17,20H2,1H3,(H,35,39)	UUWVSSXXHKEBGA-UHFFFAOYSA-N	328339	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 477::US9663496, Compound 477	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328339&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710616	384573266							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644545	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1C	InChI=1S/C33H29N5O5/c1-21-28(13-14-30(36-21)43-27-8-3-22(19-34)4-9-27)37-32(40)25-7-12-29(35-20-25)33(41)38-17-15-24(16-18-38)31(39)23-5-10-26(42-2)11-6-23/h3-14,20,24H,15-18H2,1-2H3,(H,37,40)	YOZDAUSMDOLDJM-UHFFFAOYSA-N	328340	N-(6-(4-cyanophenoxy)- 2-methylpyridin-3-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 478::US9663496, Compound 478	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328340&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710622	384573267							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644546	Cc1nc(Oc2ccc(cc2)C#N)ccc1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(F)cc1F	InChI=1S/C32H25F2N5O4/c1-19-27(10-11-29(37-19)43-24-6-2-20(17-35)3-7-24)38-31(41)22-4-9-28(36-18-22)32(42)39-14-12-21(13-15-39)30(40)25-8-5-23(33)16-26(25)34/h2-11,16,18,21H,12-15H2,1H3,(H,38,41)	FGKOOCQTYBWAPY-UHFFFAOYSA-N	328341	N-(6-(4-cyanophenoxy)- 2-methylpyridin-3-yl)-6- (4-(2,4-difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 479::US9663496, Compound 479	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328341&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710669	384573268							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644547	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(=O)N(C)C)nc1	InChI=1S/C34H33N5O6/c1-38(2)33(42)24-6-12-28(13-7-24)45-30-15-9-26(21-36-30)37-32(41)25-8-14-29(35-20-25)34(43)39-18-16-23(17-19-39)31(40)22-4-10-27(44-3)11-5-22/h4-15,20-21,23H,16-19H2,1-3H3,(H,37,41)	HIHGKUXVUVLGOQ-UHFFFAOYSA-N	328342	N-(6-(4- (dimethylcarbamoyl)  phenoxy)pyridin-3-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 480::US9663496, Compound 480	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328342&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710595	384573269							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644548	CN(C)C(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C33H29F2N5O5/c1-39(2)32(43)21-3-8-25(9-4-21)45-29-12-7-24(19-37-29)38-31(42)22-5-11-28(36-18-22)33(44)40-15-13-20(14-16-40)30(41)26-10-6-23(34)17-27(26)35/h3-12,17-20H,13-16H2,1-2H3,(H,38,42)	CSMZDTSEHGVTML-UHFFFAOYSA-N	328343	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- (dimethylcarbamoyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 481::US9663496, Compound 481	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328343&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710329	384573270							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644549	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N(C)C1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C34H37N5O4/c1-37(29-15-17-38(18-16-29)23-25-5-3-24(21-35)4-6-25)33(41)28-9-12-31(36-22-28)34(42)39-19-13-27(14-20-39)32(40)26-7-10-30(43-2)11-8-26/h3-12,22,27,29H,13-20,23H2,1-2H3	FRYJAPPODQHJRU-UHFFFAOYSA-N	328344	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1-carbonyl)- N-methylnicotinamide::US10377742, Compound 482::US9663496, Compound 482	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328344&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710664	384573271							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644550	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N(C)C1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C34H37F3N4O5/c1-39(27-15-17-40(18-16-27)22-23-3-8-29(9-4-23)46-34(35,36)37)32(43)26-7-12-30(38-21-26)33(44)41-19-13-25(14-20-41)31(42)24-5-10-28(45-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3	MEOATWALOAIMIC-UHFFFAOYSA-N	328345	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-methyl-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 483::US9663496, Compound 483	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328345&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710720	384573272							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644551	COc1ccc(CN2CCC(CC2)N(C)C(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C34H40N4O5/c1-36(28-16-18-37(19-17-28)23-24-4-9-29(42-2)10-5-24)33(40)27-8-13-31(35-22-27)34(41)38-20-14-26(15-21-38)32(39)25-6-11-30(43-3)12-7-25/h4-13,22,26,28H,14-21,23H2,1-3H3	HHOJNLQASSTSAG-UHFFFAOYSA-N	328346	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4-yl)-N- methylnicotinamide::US10377742, Compound 484::US9663496, Compound 484	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328346&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710662	384573273							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644552	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(C)(=O)=O)cn2)cc1	InChI=1S/C32H30N4O7S/c1-21(37)22-3-7-26(8-4-22)43-30-14-6-24(20-34-30)35-31(38)23-5-13-29(33-19-23)32(39)36-17-15-27(16-18-36)42-25-9-11-28(12-10-25)44(2,40)41/h3-14,19-20,27H,15-18H2,1-2H3,(H,35,38)	KMYQYHNKDDWDNU-UHFFFAOYSA-N	328347	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 485	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328347	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328347&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710507	384573274							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644553	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(=O)(=O)C3CC3)cn2)cc1	InChI=1S/C34H32N4O7S/c1-22(39)23-2-6-27(7-3-23)45-32-15-5-25(21-36-32)37-33(40)24-4-14-31(35-20-24)34(41)38-18-16-28(17-19-38)44-26-8-10-29(11-9-26)46(42,43)30-12-13-30/h2-11,14-15,20-21,28,30H,12-13,16-19H2,1H3,(H,37,40)	MAJDJUWLOQSGFM-UHFFFAOYSA-N	328348	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 486::US9663496, Compound 486	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328348&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710579	384573275							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644554	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCN(CC3)c3ccc(cc3)S(C)(=O)=O)cn2)cc1	InChI=1S/C31H29N5O6S/c1-21(37)22-3-9-26(10-4-22)42-29-14-6-24(20-33-29)34-30(38)23-5-13-28(32-19-23)31(39)36-17-15-35(16-18-36)25-7-11-27(12-8-25)43(2,40)41/h3-14,19-20H,15-18H2,1-2H3,(H,34,38)	NRYUKBXJAGTLND-UHFFFAOYSA-N	328349	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  phenyl)piperazine-1- carbonyl)nicotinamide::US9663496, Compound 487	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328349&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710455	384573276							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644555	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C(C)=O)nc2)cc1	InChI=1S/C34H33N5O6/c1-22(40)23-4-10-28(11-5-23)45-31-15-9-26(21-36-31)37-32(41)25-8-14-30(35-20-25)34(43)39-18-16-29(17-19-39)44-27-12-6-24(7-13-27)33(42)38(2)3/h4-15,20-21,29H,16-19H2,1-3H3,(H,37,41)	IDAXHXKLJMZMTG-UHFFFAOYSA-N	328350	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 488::US9663496, Compound 488	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328350	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328350&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710520	384573277							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644556	CC(C)S(=O)(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(C)=O)nc1	InChI=1S/C33H33N5O6S/c1-22(2)45(42,43)29-12-8-27(9-13-29)37-16-18-38(19-17-37)33(41)30-14-6-25(20-34-30)32(40)36-26-7-15-31(35-21-26)44-28-10-4-24(5-11-28)23(3)39/h4-15,20-22H,16-19H2,1-3H3,(H,36,40)	NMBFWLCKYSMNRH-UHFFFAOYSA-N	328351	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (isopropylsulfonyl)  phenyl)piperazine-1- carbonyl)nicotinamide::US9663496, Compound 489	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328351	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328351&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710294	384573278							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644557	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C(=O)N(C)C)CC1	InChI=1S/C35H41N5O5/c1-38(2)34(43)27-6-4-24(5-7-27)23-39-18-16-29(17-19-39)37-33(42)28-10-13-31(36-22-28)35(44)40-20-14-26(15-21-40)32(41)25-8-11-30(45-3)12-9-25/h4-13,22,26,29H,14-21,23H2,1-3H3,(H,37,42)	MJFMCJRNWDTCIF-UHFFFAOYSA-N	328352	N-(1-(4- (dimethylcarbamoyl)  benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 490::US9663496, Compound 490	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328352&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710509	384573279							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644558	Fc1ccc(CN2CCN(CC2)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C29H32FN7O/c30-25-7-5-24(6-8-25)21-36-15-17-37(18-16-36)28-10-9-27(33-34-28)29(38)32-26-11-13-35(14-12-26)20-23-3-1-22(19-31)2-4-23/h1-10,26H,11-18,20-21H2,(H,32,38)	PDHJZIQJMYUJNZ-UHFFFAOYSA-N	328353	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- fluorobenzyl)piperazin- 1-yl)pyridazine-3- carboxamide::US10377742, Compound 491::US9663496, Compound 491	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328353&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073206	384573280							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644559	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F5N5O3S/c32-45(33,34,35,36)28-8-6-26(7-9-28)44-27-13-17-41(18-14-27)31(43)24-5-10-29(38-20-24)30(42)39-25-11-15-40(16-12-25)21-23-3-1-22(19-37)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,39,42)	BAQNKGBJRYOBKF-UHFFFAOYSA-N	328354	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 492::US9663496, Compound 492	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328354&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119980	384573281							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644560	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F5N5O3S/c32-45(33,34,35,36)28-8-6-26(7-9-28)44-27-13-17-41(18-14-27)31(43)29-10-5-24(20-38-29)30(42)39-25-11-15-40(16-12-25)21-23-3-1-22(19-37)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,39,42)	YQNDTFLKFFIKOY-UHFFFAOYSA-N	328355	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 493::US9663496, Compound 493	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328355&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119968	384573282							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644561	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(F)(F)(F)(F)F)cc1	InChI=1S/C31H32F8N4O4S/c32-31(33,34)47-26-4-1-21(2-5-26)20-42-15-11-23(12-16-42)41-29(44)22-3-10-28(40-19-22)30(45)43-17-13-25(14-18-43)46-24-6-8-27(9-7-24)48(35,36,37,38)39/h1-10,19,23,25H,11-18,20H2,(H,41,44)	IRXMWPNSDLENHP-UHFFFAOYSA-N	328356	6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 494::US9663496, Compound 494	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328356&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652378	384573283							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644562	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(F)(F)(F)(F)F)cc1	InChI=1S/C31H35F5N4O4S/c1-43-25-5-2-22(3-6-25)21-39-16-12-24(13-17-39)38-30(41)23-4-11-29(37-20-23)31(42)40-18-14-27(15-19-40)44-26-7-9-28(10-8-26)45(32,33,34,35)36/h2-11,20,24,27H,12-19,21H2,1H3,(H,38,41)	MZWKXTIWRUKNLP-UHFFFAOYSA-N	328357	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 495::US9663496, Compound 495	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328357	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328357&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119908	384573284							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644563	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(F)(F)(F)(F)F)cn2)cc1	InChI=1S/C29H24F6N4O4S/c30-20-2-5-23(6-3-20)43-27-12-4-21(18-37-27)38-28(40)19-1-11-26(36-17-19)29(41)39-15-13-24(14-16-39)42-22-7-9-25(10-8-22)44(31,32,33,34)35/h1-12,17-18,24H,13-16H2,(H,38,40)	BPLWMEIZMICBAU-UHFFFAOYSA-N	328358	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 496::US9663496, Compound 496	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328358&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119984	384573285							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644564	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H24F5N5O4S/c31-45(32,33,34,35)26-9-7-23(8-10-26)43-25-13-15-40(16-14-25)30(42)27-11-3-21(18-37-27)29(41)39-22-4-12-28(38-19-22)44-24-5-1-20(17-36)2-6-24/h1-12,18-19,25H,13-16H2,(H,39,41)	GEWONQLQWOVJJA-UHFFFAOYSA-N	328359	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 497::US9663496, Compound 497	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328359&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119930	384573286							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644565	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1(F)F	InChI=1S/C33H33F2N5O4/c1-44-27-9-6-24(7-10-27)30(41)25-12-16-40(17-13-25)32(43)28-11-8-26(19-37-28)31(42)38-29-14-15-39(21-33(29,34)35)20-23-4-2-22(18-36)3-5-23/h2-11,19,25,29H,12-17,20-21H2,1H3,(H,38,42)	GLKJXMSLKUEYGJ-UHFFFAOYSA-N	328360	N-(1-(4-cyanobenzyl)- 3,3-difluoropiperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 498::US9663496, Compound 498	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328360&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652379	384573287							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644073	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H33FN6O2/c32-27-8-5-25(6-9-27)22-37-15-17-38(18-16-37)31(40)29-10-7-26(20-34-29)30(39)35-28-11-13-36(14-12-28)21-24-3-1-23(19-33)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,35,39)	OFHFMKWBHZUCBG-UHFFFAOYSA-N	327862	N-(4-(4- cyanobenzyl)piperadin- 4-yl)-6-(4-(4- fluorobenzyl)piperizine- 1-carbonyl)picolinamide::US10377742, Compound 1::US9663496, Compound 1	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327862&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084602	384582778							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644074	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCNCC1	InChI=1S/C24H28N6O2/c25-15-18-1-3-19(4-2-18)17-29-11-7-21(8-12-29)28-23(31)22-6-5-20(16-27-22)24(32)30-13-9-26-10-14-30/h1-6,16,21,26H,7-14,17H2,(H,28,31)	XJFFGYUNDZFZOG-UHFFFAOYSA-N	327863	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(piperazine-1- carbonyl)picolinamide::US10377742, Compound 2::US9663496, Compound 2	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327863&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073382	384582779							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644075	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C29H31F2N5O2/c30-25-6-1-22(2-7-25)20-33-11-15-35(16-12-33)28(37)24-5-10-27(32-19-24)29(38)36-17-13-34(14-18-36)21-23-3-8-26(31)9-4-23/h1-10,19H,11-18,20-21H2	ZCVDBEVZVHBBJC-UHFFFAOYSA-N	327864	US10377742, Compound 3::US9663496, Compound 3::pyridine-2,5-diylbis((4- (4- fluorobenzyl)piperazin- 1-yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327864&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652031	384582780							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644076	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN6O3/c32-26-8-3-23(4-9-26)21-36-15-17-38(18-16-36)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-37(14-12-27)30(40)24-5-1-22(19-33)2-6-24/h1-10,20,27H,11-18,21H2,(H,35,39)	AIJFSOPJUPPZAC-UHFFFAOYSA-N	327865	N-(1-(4- cyanobenzoyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 4::US9663496, Compound 4	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327865&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652032	384582781							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644077	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cccc(Cc2ccccc2)c1	InChI=1S/C33H31N5O2/c34-21-25-9-11-26(12-10-25)23-38-17-15-29(16-18-38)36-33(40)31-14-13-28(22-35-31)32(39)37-30-8-4-7-27(20-30)19-24-5-2-1-3-6-24/h1-14,20,22,29H,15-19,23H2,(H,36,40)(H,37,39)	PJEQHYITGSHAGC-UHFFFAOYSA-N	327866	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(3- benzylphenyl)pyridine- 2,5-dicarboxamide::US10377742, Compound 5::US9663496, Compound 5	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327866&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652033	384582782							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644078	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C30H31FN6O4S/c31-25-6-1-23(2-7-25)21-35-15-17-36(18-16-35)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-37(14-12-26)42(40,41)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)	MJVVGQPISJDCKE-UHFFFAOYSA-N	327867	N-(4-((4- cyanophenyl)sulfonyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 6::US9663496, Compound 6	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327867&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073245	384582783							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644079	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)C2CCCCC2)cc1	InChI=1S/C30H38FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h6-11,20,23,26H,1-5,12-19,21H2,(H,33,37)	KUYAVZMMGBODBA-UHFFFAOYSA-N	327868	N-(1- (cyclohexanecarbonyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 7::US9663496, Compound 7	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327868&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652371	384582784							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644080	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccccc2)cc1	InChI=1S/C30H32FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h1-11,20,26H,12-19,21H2,(H,33,37)	PGYYJEYPHRIKEA-UHFFFAOYSA-N	327869	N-(1-(benzoyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 8::US9663496, Compound 8	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327869&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652372	384582785							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644081	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccn(Cc3ccc(cc3)C#N)n2)cc1	InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)19-35-13-15-36(16-14-35)29(39)24-7-10-26(32-18-24)28(38)33-27-11-12-37(34-27)20-23-3-1-21(17-31)2-4-23/h1-12,18H,13-16,19-20H2,(H,33,34,38)	RJDFHCCYYFFSBE-UHFFFAOYSA-N	327870	N-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 9::US9663496, Compound 9	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327870&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073277	384582786							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644082	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Cc3ccccc3)cc2)cc1	InChI=1S/C31H29FN4O2/c32-27-11-6-25(7-12-27)22-35-16-18-36(19-17-35)31(38)26-10-15-29(33-21-26)30(37)34-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,34,37)	VRFSYYBIXZHSAS-UHFFFAOYSA-N	327871	N-(4-benzylphenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 10::US9663496, Compound 10	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327871&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073517	384582787							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644083	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-26-11-6-22(7-12-26)21-34-16-18-35(19-17-34)30(37)25-10-15-28(32-20-25)29(36)33-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,33,36)	PRJISZJJPGFGHG-UHFFFAOYSA-N	327872	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(4- phenylphenyl)  picolinamide::US10377742, Compound 11::US9663496, Compound 11	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327872&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073329	384582788							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644084	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(c2)-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-26-12-9-22(10-13-26)21-34-15-17-35(18-16-34)30(37)25-11-14-28(32-20-25)29(36)33-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,33,36)	DEAYGZRRXFNGTA-UHFFFAOYSA-N	327873	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(3- phenylphenyl)  picolinamide::US10377742, Compound 12::US9663496, Compound 12	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327873&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073201	384582789							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644085	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC3CCCCC3)CC2)cc1	InChI=1S/C30H40FN5O2/c31-26-9-6-24(7-10-26)22-35-16-18-36(19-17-35)30(38)25-8-11-28(32-20-25)29(37)33-27-12-14-34(15-13-27)21-23-4-2-1-3-5-23/h6-11,20,23,27H,1-5,12-19,21-22H2,(H,33,37)	KCGHFTHUSALUFF-UHFFFAOYSA-N	327874	N-(1-(cyclohexylmethyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 13::US9663496, Compound 13	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327874&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073564	384582790							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644086	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)c2ccccc2)cc1	InChI=1S/C29H32FN5O2/c30-24-9-6-22(7-10-24)21-33-16-18-35(19-17-33)29(37)23-8-11-27(31-20-23)28(36)32-25-12-14-34(15-13-25)26-4-2-1-3-5-26/h1-11,20,25H,12-19,21H2,(H,32,36)	HQTGOKGRHCNFPD-UHFFFAOYSA-N	327875	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1- (phenyl)piperidin-4- yl)picolinamide::US10377742, Compound 14::US9663496, Compound 14	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327875&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652373	384582791							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644087	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCC3(CCN(Cc4ccc(cc4)C#N)C3)CC2)cc1	InChI=1S/C34H37FN6O2/c35-30-8-5-28(6-9-30)23-38-17-19-41(20-18-38)32(42)29-7-10-31(37-22-29)33(43)40-15-12-34(13-16-40)11-14-39(25-34)24-27-3-1-26(21-36)2-4-27/h1-10,22H,11-20,23-25H2	GUOFMHPMAHVMLC-UHFFFAOYSA-N	327876	4-((8-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinoyl)- 2,8- diazaspiro[4.5]decan-2- yl)methyl)benzonitrile::US10377742, Compound 15::US9663496, Compound 15	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327876&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652374	384582792							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644088	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	InChI=1S/C30H27FN4O3/c31-24-9-6-22(7-10-24)21-34-16-18-35(19-17-34)30(37)23-8-15-28(32-20-23)29(36)33-25-11-13-27(14-12-25)38-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,33,36)	KFWUZHLIUCMOPR-UHFFFAOYSA-N	327877	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- phenoxyphenyl)  picolinamide::US10377742, Compound 16::US9663496, Compound 16	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327877&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652375	384582793							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644089	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(OCc3ccccc3)cc2)cc1	InChI=1S/C30H28FN3O2/c31-27-11-6-23(7-12-27)21-33-16-18-34(19-17-33)30(35)26-10-15-29(32-20-26)25-8-13-28(14-9-25)36-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2	LFRKRHVIDSBBJO-UHFFFAOYSA-N	327878	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- (benzyloxy)phenyl)  pyridin-3-yl)methanone::US10377742, Compound 17::US9663496, Compound 17	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327878&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652712	384582794							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644090	CC(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1	InChI=1S/C31H36FN5O2/c1-23(25-5-3-2-4-6-25)36-15-13-28(14-16-36)34-30(38)29-12-9-26(21-33-29)31(39)37-19-17-35(18-20-37)22-24-7-10-27(32)11-8-24/h2-12,21,23,28H,13-20,22H2,1H3,(H,34,38)	OTTMHRBJZANTRA-UHFFFAOYSA-N	327879	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(1- phenylethyl)piperidin-4- yl)picolinamide::US10377742, Compound 18::US9663496, Compound 18	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327879&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652713	384582795							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644091	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-25-13-10-22(11-14-25)21-34-16-18-35(19-17-34)30(37)24-12-15-28(32-20-24)29(36)33-27-9-5-4-8-26(27)23-6-2-1-3-7-23/h1-15,20H,16-19,21H2,(H,33,36)	DKZIWVLUHXKRHI-UHFFFAOYSA-N	327880	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(2- phenylphenyl)  picolinamide::US10377742, Compound 19::US9663496, Compound 19	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327880&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652714	384582796							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644092	[O-][N+](=O)c1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C30H26FN5O4/c31-25-8-1-21(2-9-25)20-34-15-17-35(18-16-34)30(38)24-7-14-28(32-19-24)29(37)33-26-10-3-22(4-11-26)23-5-12-27(13-6-23)36(39)40/h1-14,19H,15-18,20H2,(H,33,37)	GAYRGESOQUQOTJ-UHFFFAOYSA-N	327881	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- nitrophenyl)phenyl)  picolinamide::US10377742, Compound 20::US9663496, Compound 20	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327881&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652715	384582797							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644093	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(Oc3ccccc3)c2)cc1	InChI=1S/C30H27FN4O3/c31-24-12-9-22(10-13-24)21-34-15-17-35(18-16-34)30(37)23-11-14-28(32-20-23)29(36)33-25-5-4-8-27(19-25)38-26-6-2-1-3-7-26/h1-14,19-20H,15-18,21H2,(H,33,36)	CQQMMXMEYNOOTM-UHFFFAOYSA-N	327882	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(3- phenoxyphenyl)  picolinamide::US10377742, Compound 21::US9663496, Compound 21	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327882&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652716	384582798							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644094	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1	InChI=1S/C30H28FN3O2/c31-27-12-9-23(10-13-27)21-33-15-17-34(18-16-33)30(35)26-11-14-29(32-20-26)25-7-4-8-28(19-25)36-22-24-5-2-1-3-6-24/h1-14,19-20H,15-18,21-22H2	QSFRHVLXMAFXQR-UHFFFAOYSA-N	327883	(6-(3- (benzyloxy)phenyl)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 22::US9663496, Compound 22	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327883&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653045	384582799							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644095	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cnn(Cc3ccc(cc3)C#N)c2)cc1	InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)18-35-11-13-36(14-12-35)29(39)24-7-10-27(32-16-24)28(38)34-26-17-33-37(20-26)19-23-3-1-21(15-31)2-4-23/h1-10,16-17,20H,11-14,18-19H2,(H,34,38)	NFOUIFJMANKDPS-UHFFFAOYSA-N	327884	N-(1-(4-cyanobenzyl)- 1H-pyrazol-4-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 23::US9663496, Compound 23	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327884&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653046	384582800							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644096	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C#N)cc1	InChI=1S/C31H26FN5O2/c32-27-10-3-23(4-11-27)21-36-15-17-37(18-16-36)31(39)26-9-14-29(34-20-26)30(38)35-28-12-7-25(8-13-28)24-5-1-22(19-33)2-6-24/h1-14,20H,15-18,21H2,(H,35,38)	XSUMTXIVYVXHQF-UHFFFAOYSA-N	327885	N-(4-(4- cyanophenyl)phenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 24::US9663496, Compound 24	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327885&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653047	384582801							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644097	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C31H26F4N4O2/c32-26-10-1-21(2-11-26)20-38-15-17-39(18-16-38)30(41)24-7-14-28(36-19-24)29(40)37-27-12-5-23(6-13-27)22-3-8-25(9-4-22)31(33,34)35/h1-14,19H,15-18,20H2,(H,37,40)	RBSXAXHVCUKMIZ-UHFFFAOYSA-N	327886	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- trifluoromethylphenyl)  phenyl)picolinamide::US10377742, Compound 25::US9663496, Compound 25	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327886&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653048	384582802							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644098	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)C(=O)c2ccccc2)cc1	InChI=1S/C31H27FN4O3/c32-26-11-6-22(7-12-26)21-35-16-18-36(19-17-35)31(39)25-10-15-28(33-20-25)30(38)34-27-13-8-24(9-14-27)29(37)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,34,38)	IVEYKDVYNMMLFY-UHFFFAOYSA-N	327887	N-(4-benzoylphenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 26::US9663496, Compound 26	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327887&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653049	384582803							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644099	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(OCc3ccccc3)cc2)cc1	InChI=1S/C31H29FN4O3/c32-26-9-6-23(7-10-26)21-35-16-18-36(19-17-35)31(38)25-8-15-29(33-20-25)30(37)34-27-11-13-28(14-12-27)39-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2,(H,34,37)	IKKVPXFGSRKNJV-UHFFFAOYSA-N	327888	N-(4-benzyloxyphenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 27::US9663496, Compound 27	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327888&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653409	384582804							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644100	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Br)cc2)cc1	InChI=1S/C24H22BrFN4O2/c25-19-4-8-21(9-5-19)28-23(31)22-10-3-18(15-27-22)24(32)30-13-11-29(12-14-30)16-17-1-6-20(26)7-2-17/h1-10,15H,11-14,16H2,(H,28,31)	MTYUQDCNXVHHAR-UHFFFAOYSA-N	327889	N-(4-bromophenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 28::US9663496, Compound 28	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327889&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653410	384582805							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644101	COc1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H29FN4O3/c1-39-28-13-6-24(7-14-28)23-4-11-27(12-5-23)34-30(37)29-15-8-25(20-33-29)31(38)36-18-16-35(17-19-36)21-22-2-9-26(32)10-3-22/h2-15,20H,16-19,21H2,1H3,(H,34,37)	DVMILXSBZSNOPF-UHFFFAOYSA-N	327890	N-(4-(4- methoxyphenyl)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 29::US9663496, Compound 29	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327890&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653411	384582806							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644102	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Cc4ccccc4)cc3)nc2)cc1	InChI=1S/C30H29FN4O/c31-27-11-6-25(7-12-27)22-34-16-18-35(19-17-34)30(36)26-10-15-29(32-21-26)33-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,32,33)	PXCXFGLKFBBGMD-UHFFFAOYSA-N	327891	(6-(4- benzylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 30::US9663496, Compound 30	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327891&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653412	384582807							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644103	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC3(C2)CCN(Cc2ccc(cc2)C#N)CC3)cc1	InChI=1S/C33H37FN6O/c34-30-8-5-28(6-9-30)24-38-17-19-39(20-18-38)32(41)29-7-10-31(36-22-29)40-16-13-33(25-40)11-14-37(15-12-33)23-27-3-1-26(21-35)2-4-27/h1-10,22H,11-20,23-25H2	OLOFHQKCBQKIAJ-UHFFFAOYSA-N	327892	4-((2-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2-yl)- 2,8- diazaspiro[4.5]decan-8- yl)methyl)benzonitrile::US9663496, Compound 31	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327892&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653413	384582808							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644104	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccc(c2)C#N)cc1	InChI=1S/C31H26FN5O2/c32-27-9-4-22(5-10-27)21-36-14-16-37(17-15-36)31(39)26-8-13-29(34-20-26)30(38)35-28-11-6-24(7-12-28)25-3-1-2-23(18-25)19-33/h1-13,18,20H,14-17,21H2,(H,35,38)	GVARIDOMGKXGSD-UHFFFAOYSA-N	327893	N-(4-(3- cyanophenyl)phenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 32::US9663496, Compound 32	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327893&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653758	384582809							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644105	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3cccc(c3)-c3ccccc3)nc2)cc1	InChI=1S/C29H27FN4O/c30-26-12-9-22(10-13-26)21-33-15-17-34(18-16-33)29(35)25-11-14-28(31-20-25)32-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,31,32)	SZJATISBSPFCJL-UHFFFAOYSA-N	327894	(6-(3- phenylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 33::US9663496, Compound 33	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327894&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653759	384582810							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644106	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1	InChI=1S/C29H27FN4O2/c30-24-9-6-22(7-10-24)21-33-16-18-34(19-17-33)29(35)23-8-15-28(31-20-23)32-25-11-13-27(14-12-25)36-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,31,32)	SCZKOAZZRCYNFT-UHFFFAOYSA-N	327895	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxyphenylamino)  pyridin-3-yl)methanone::US10377742, Compound 34::US9663496, Compound 34	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327895&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653760	384582811							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644107	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(cc2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C32H28FN5O2/c33-29-12-5-25(6-13-29)22-37-15-17-38(18-16-37)32(40)28-11-14-30(35-21-28)26-7-9-27(10-8-26)31(39)36-20-24-3-1-23(19-34)2-4-24/h1-14,21H,15-18,20,22H2,(H,36,39)	PTFCCBDWBUWRTB-UHFFFAOYSA-N	327896	(6-(4-(4- cyanobenzylcarbamoyl)  phenyl)pyridin-3-yl)(4- (4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 35::US9663496, Compound 35	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327896&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653761	384582812							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644108	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1	InChI=1S/C30H33FN6O/c31-27-8-5-25(6-9-27)22-36-15-17-37(18-16-36)30(38)26-7-10-29(33-20-26)34-28-11-13-35(14-12-28)21-24-3-1-23(19-32)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,33,34)	AUSCOAAXXZHOLH-UHFFFAOYSA-N	327897	(6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3- yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 36::US9663496, Compound 36	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327897&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084728	384582813							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644109	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(cc3)-c3ccccc3)nc2)cc1	InChI=1S/C29H27FN4O/c30-26-11-6-22(7-12-26)21-33-16-18-34(19-17-33)29(35)25-10-15-28(31-20-25)32-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,31,32)	IDNTUUFQESKWJF-UHFFFAOYSA-N	327898	(6-(4- phenylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 37::US9663496, Compound 37	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327898&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653762	384582814							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644110	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1	InChI=1S/C31H28N8O2/c32-17-22-1-5-24(6-2-22)20-38-14-11-27(12-15-38)35-31(41)28-10-9-26(19-34-28)30(40)36-29-13-16-39(37-29)21-25-7-3-23(18-33)4-8-25/h1-10,13,16,19,27H,11-12,14-15,20-21H2,(H,35,41)(H,36,37,40)	OWORLXKPKKUEKB-UHFFFAOYSA-N	327899	N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4- cyanobenzyl)piperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 38::US9663496, Compound 38	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327899&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654098	384582815							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644111	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cc[nH]c2)cc1	InChI=1S/C28H26FN5O2/c29-24-6-1-20(2-7-24)19-33-13-15-34(16-14-33)28(36)23-5-10-26(31-18-23)27(35)32-25-8-3-21(4-9-25)22-11-12-30-17-22/h1-12,17-18,30H,13-16,19H2,(H,32,35)	ANLDAUPWGMIDKB-UHFFFAOYSA-N	327900	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(1H- pyrrol-3- yl)phenyl)picolinamide::US10377742, Compound 39::US9663496, Compound 39	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327900&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654099	384582816							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644112	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)N2CCOCC2)cc1	InChI=1S/C28H30FN5O3/c29-23-4-1-21(2-5-23)20-32-11-13-34(14-12-32)28(36)22-3-10-26(30-19-22)27(35)31-24-6-8-25(9-7-24)33-15-17-37-18-16-33/h1-10,19H,11-18,20H2,(H,31,35)	VHXPMMSGAZXAOF-UHFFFAOYSA-N	327901	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- morpholinophenyl)  picolinamide::US10377742, Compound 40::US9663496, Compound 40	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327901&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654100	384582817							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644113	CN1CCN(CC1)c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C29H33FN6O2/c1-33-12-16-35(17-13-33)26-9-7-25(8-10-26)32-28(37)27-11-4-23(20-31-27)29(38)36-18-14-34(15-19-36)21-22-2-5-24(30)6-3-22/h2-11,20H,12-19,21H2,1H3,(H,32,37)	QSOJIZDCHOEGLA-UHFFFAOYSA-N	327902	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methylpiperazin-1- yl)phenyl)picolinamide::US10377742, Compound 41::US9663496, Compound 41	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327902&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654101	384582818							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644114	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(c2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C32H28FN5O2/c33-29-11-8-25(9-12-29)22-37-14-16-38(17-15-37)32(40)28-10-13-30(35-21-28)26-2-1-3-27(18-26)31(39)36-20-24-6-4-23(19-34)5-7-24/h1-13,18,21H,14-17,20,22H2,(H,36,39)	IGRUICVFLYEORO-UHFFFAOYSA-N	327904	(6-(3-(4- cyanobenzylcarbamoyl)  phenyl)pyridin-3yl)(4- (4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 42::US9663496, Compound 42	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327904&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654102	384582820							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644115	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cnn(Cc2ccc(cc2)C#N)c1	InChI=1S/C31H28N8O2/c32-15-22-1-5-24(6-2-22)19-38-13-11-27(12-14-38)36-31(41)29-10-9-26(17-34-29)30(40)37-28-18-35-39(21-28)20-25-7-3-23(16-33)4-8-25/h1-10,17-18,21,27H,11-14,19-20H2,(H,36,41)(H,37,40)	YHEKUCFWUXSDKM-UHFFFAOYSA-N	327905	N5-(1-(4-cyanobenzyl)- 1H-pyrazol-4-yl)-N2-(1- (4- cyanobenzyl)piperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 43::US9663496, Compound 43	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327905&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654434	384582821							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644116	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C33H29FN6O3/c34-28-10-5-25(6-11-28)22-39-15-17-40(18-16-39)33(43)27-9-14-30(36-21-27)32(42)38-29-12-7-26(8-13-29)31(41)37-20-24-3-1-23(19-35)2-4-24/h1-14,21H,15-18,20,22H2,(H,37,41)(H,38,42)	BPUSTKQLALECFR-UHFFFAOYSA-N	327906	N-(4-(4- cyanobenzylcarbamoyl)  phenyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 47::US9663496, Compound 47	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327906&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654437	384582822							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644117	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(cc3)C(=O)NCc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C32H29FN6O2/c33-28-10-5-25(6-11-28)22-38-15-17-39(18-16-38)32(41)27-9-14-30(35-21-27)37-29-12-7-26(8-13-29)31(40)36-20-24-3-1-23(19-34)2-4-24/h1-14,21H,15-18,20,22H2,(H,35,37)(H,36,40)	LTAMCBAUTUHECW-UHFFFAOYSA-N	327907	(6-(4-(4- cyanobenzylcarbamoyl)  phenylamino)pyridin-3- yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 48::US9663496, Compound 48	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327907&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654438	384582823							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644118	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C30H32F3N5O2/c31-24-4-1-21(2-5-24)19-37-11-13-38(14-12-37)30(40)23-3-6-28(34-18-23)29(39)35-27-7-9-36(10-8-27)20-22-15-25(32)17-26(33)16-22/h1-6,15-18,27H,7-14,19-20H2,(H,35,39)	JEBWTTQATIZHGU-UHFFFAOYSA-N	327908	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 49::US9663496, Compound 49	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327908&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654780	384582824							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644119	Cc1cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)ccc1F	InChI=1S/C31H35F2N5O2/c1-22-18-24(4-8-28(22)33)21-36-12-10-27(11-13-36)35-30(39)29-9-5-25(19-34-29)31(40)38-16-14-37(15-17-38)20-23-2-6-26(32)7-3-23/h2-9,18-19,27H,10-17,20-21H2,1H3,(H,35,39)	MYKBCPMYGPOKII-UHFFFAOYSA-N	327909	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluoro-3- methylbenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 50::US9663496, Compound 50	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327909&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654781	384582825							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644120	COc1ccc(CC2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H37FN4O3/c1-40-29-13-6-24(7-14-29)20-23-4-11-28(12-5-23)35-31(38)30-15-8-26(21-34-30)32(39)37-18-16-36(17-19-37)22-25-2-9-27(33)10-3-25/h2-3,6-10,13-15,21,23,28H,4-5,11-12,16-20,22H2,1H3,(H,35,38)	JINWVOWDQOOBDT-UHFFFAOYSA-N	327910	N-(1-(4- chlorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 51::US9663496, Compound 51	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327910&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073262	384582826							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644121	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(Cl)cc3)CC2)cc1	InChI=1S/C30H33ClFN5O2/c31-25-6-1-22(2-7-25)20-35-13-11-27(12-14-35)34-29(38)28-10-5-24(19-33-28)30(39)37-17-15-36(16-18-37)21-23-3-8-26(32)9-4-23/h1-10,19,27H,11-18,20-21H2,(H,34,38)	BORCORLFDUVXFQ-UHFFFAOYSA-N	327911	N-(1-(4- chlorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 52::US9663496, Compound 52	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327911&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654782	384582827							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644122	Cc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)cc1	InChI=1S/C31H29FN4O3/c1-22-2-11-27(12-3-22)39-28-13-9-26(10-14-28)34-30(37)29-15-6-24(20-33-29)31(38)36-18-16-35(17-19-36)21-23-4-7-25(32)8-5-23/h2-15,20H,16-19,21H2,1H3,(H,34,37)	RMWNMWQMKJQMNP-UHFFFAOYSA-N	327912	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methylphenoxy)phenyl)  picolinamide::US10377742, Compound 53::US9663496, Compound 53	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327912&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654783	384582828							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644123	COc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)cc1	InChI=1S/C31H29FN4O4/c1-39-26-11-13-28(14-12-26)40-27-9-7-25(8-10-27)34-30(37)29-15-4-23(20-33-29)31(38)36-18-16-35(17-19-36)21-22-2-5-24(32)6-3-22/h2-15,20H,16-19,21H2,1H3,(H,34,37)	RDGQWELXIWGGAA-UHFFFAOYSA-N	327913	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methoxyphenoxy)  phenyl)picolinamide::US10377742, Compound 54::US9663496, Compound 54	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327913&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654784	384582829							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644124	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(F)c3)cc2)cc1	InChI=1S/C30H26F2N4O3/c31-23-7-4-21(5-8-23)20-35-14-16-36(17-15-35)30(38)22-6-13-28(33-19-22)29(37)34-25-9-11-26(12-10-25)39-27-3-1-2-24(32)18-27/h1-13,18-19H,14-17,20H2,(H,34,37)	AFHGWQBLKGCROK-UHFFFAOYSA-N	327914	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- fluorophenoxy)phenyl)  picolinamide::US10377742, Compound 55::US9663496, Compound 55	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327914&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655128	384582830							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644125	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(c3)C#N)cc2)cc1	InChI=1S/C31H26FN5O3/c32-25-7-4-22(5-8-25)21-36-14-16-37(17-15-36)31(39)24-6-13-29(34-20-24)30(38)35-26-9-11-27(12-10-26)40-28-3-1-2-23(18-28)19-33/h1-13,18,20H,14-17,21H2,(H,35,38)	ZGVPWOWZROQALT-UHFFFAOYSA-N	327915	N-(4-(3- cyanophenoxy)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 56::US9663496, Compound 56	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327915&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655129	384582831							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644126	COc1cccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)c1	InChI=1S/C31H29FN4O4/c1-39-27-3-2-4-28(19-27)40-26-12-10-25(11-13-26)34-30(37)29-14-7-23(20-33-29)31(38)36-17-15-35(16-18-36)21-22-5-8-24(32)9-6-22/h2-14,19-20H,15-18,21H2,1H3,(H,34,37)	WDGGQCRMJXHVAD-UHFFFAOYSA-N	327916	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- methoxyphenoxy)  phenyl)picolinamide::US10377742, Compound 57::US9663496, Compound 57	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327916&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655130	384582832							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644127	Cc1cccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)c1	InChI=1S/C31H29FN4O3/c1-22-3-2-4-28(19-22)39-27-12-10-26(11-13-27)34-30(37)29-14-7-24(20-33-29)31(38)36-17-15-35(16-18-36)21-23-5-8-25(32)9-6-23/h2-14,19-20H,15-18,21H2,1H3,(H,34,37)	CBGKMLBDMVQWBH-UHFFFAOYSA-N	327917	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- methylphenoxy)phenyl)  picolinamide::US10377742, Compound 58::US9663496, Compound 58	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327917&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655131	384582833							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644128	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)cc2)cc1	InChI=1S/C31H26FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)24-5-14-29(34-20-24)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-14,20H,15-18,21H2,(H,35,38)	RANWOMLEXKWTRY-UHFFFAOYSA-N	327918	N-(4-(4- cyanophenoxy)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 59::US9663496, Compound 59	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327918&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655132	384582834							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644129	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)cc1	InChI=1S/C30H26F2N4O3/c31-23-4-1-21(2-5-23)20-35-15-17-36(18-16-35)30(38)22-3-14-28(33-19-22)29(37)34-25-8-12-27(13-9-25)39-26-10-6-24(32)7-11-26/h1-14,19H,15-18,20H2,(H,34,37)	NOIUJGNQSASNRI-UHFFFAOYSA-N	327919	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- fluorophenoxy)phenyl)  picolinamide::US10377742, Compound 60::US9663496, Compound 60	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327919&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649997	384582835							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644130	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccnc2)cc1	InChI=1S/C29H26FN5O2/c30-25-8-3-21(4-9-25)20-34-14-16-35(17-15-34)29(37)24-7-12-27(32-19-24)28(36)33-26-10-5-22(6-11-26)23-2-1-13-31-18-23/h1-13,18-19H,14-17,20H2,(H,33,36)	JYDMJWGORFCYPJ-UHFFFAOYSA-N	327920	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- (pyridine-3- yl)phenyl)picolinamide::US10377742, Compound 61::US9663496, Compound 61	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327920&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649998	384582836							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644131	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccsc2)cc1	InChI=1S/C28H25FN4O2S/c29-24-6-1-20(2-7-24)18-32-12-14-33(15-13-32)28(35)22-5-10-26(30-17-22)27(34)31-25-8-3-21(4-9-25)23-11-16-36-19-23/h1-11,16-17,19H,12-15,18H2,(H,31,34)	BJRZKIVEUFLPAU-UHFFFAOYSA-N	327921	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- (thiophen-3- yl)phenyl)picolinamide::US10377742, Compound 62::US9663496, Compound 62	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327921&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649999	384582837							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644132	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-6-1-22(2-7-24)20-36-13-15-37(16-14-36)30(39)23-5-11-27(33-18-23)29(38)35-25-8-12-28(34-19-25)40-26-9-3-21(17-32)4-10-26/h1-12,18-19H,13-16,20H2,(H,35,38)	SXCVHBDVDRBZIC-UHFFFAOYSA-N	327922	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-(6-(4- cyanophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 63::US9663496, Compound 63	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327922&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650000	384582838							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644133	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(c3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-7-4-21(5-8-24)20-36-12-14-37(15-13-36)30(39)23-6-10-27(33-18-23)29(38)35-25-9-11-28(34-19-25)40-26-3-1-2-22(16-26)17-32/h1-11,16,18-19H,12-15,20H2,(H,35,38)	ASBBFNPPGCMMTH-UHFFFAOYSA-N	327923	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-(6-(3- cyanophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 64::US9663496, Compound 64	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327923&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650001	384582839							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644134	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-22-4-1-20(2-5-22)19-35-13-15-36(16-14-35)29(38)21-3-11-26(32-17-21)28(37)34-24-8-12-27(33-18-24)39-25-9-6-23(31)7-10-25/h1-12,17-18H,13-16,19H2,(H,34,37)	XOCNQFFZQFEWHW-UHFFFAOYSA-N	327924	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 65::US9663496, Compound 65	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327924&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650324	384582840							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644135	COc1cc(ccc1OC1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C#N	InChI=1S/C33H34N6O4/c1-42-31-18-25(20-35)6-9-30(31)43-28-12-16-39(17-13-28)33(41)26-7-8-29(36-21-26)32(40)37-27-10-14-38(15-11-27)22-24-4-2-23(19-34)3-5-24/h2-9,18,21,27-28H,10-17,22H2,1H3,(H,37,40)	KKQGVOSIFWFJDK-UHFFFAOYSA-N	327925	5-(4-(4-cyano-2- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 66::US9663496, Compound 66	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327925&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650325	384582841							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644136	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(F)(CC3)C(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-21-4-1-19(2-5-21)27(38)30(33)13-15-37(16-14-30)29(40)20-3-11-25(34-17-20)28(39)36-23-8-12-26(35-18-23)41-24-9-6-22(32)7-10-24/h1-12,17-18H,13-16H2,(H,36,39)	KJSYIIMVXXSKOC-UHFFFAOYSA-N	327926	5-(4-(4-fluoro-4- fluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 67::US9663496, Compound 67	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327926&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073146	384582842							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644137	Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	WQUGCKCCOOBUNT-UHFFFAOYSA-N	327927	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluoro-4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 68::US9663496, Compound 68	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327927&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073566	384582843							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644138	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O5/c1-40-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)22-4-12-27(33-18-22)30(38)35-24-7-13-28(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	LFVWKMPSGSNUPO-UHFFFAOYSA-N	327928	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 69::US9663496, Compound 69	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327928&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650328	384582844							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644139	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C30H27FN4O5/c1-38-23-8-10-24(11-9-23)39-26-14-16-35(17-15-26)30(37)20-2-12-27(32-18-20)29(36)34-22-5-13-28(33-19-22)40-25-6-3-21(31)4-7-25/h2-13,18-19,26H,14-17H2,1H3,(H,34,36)	UFHBGTJZBONLAE-UHFFFAOYSA-N	327929	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 70::US9663496, Compound 70	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327929&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650665	384582845							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644140	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H35N5O2/c36-29(32-27-13-15-33(16-14-27)22-24-7-3-1-4-8-24)28-12-11-26(21-31-28)30(37)35-19-17-34(18-20-35)23-25-9-5-2-6-10-25/h1-12,21,27H,13-20,22-23H2,(H,32,36)	OQMKCTWXRSKXFX-UHFFFAOYSA-N	327930	5-(4-benzylpiperazine-1- carbonyl)-N-(1- benzylpiperidin-4- yl)picolinamide::US10377742, Compound 72::US9663496, Compound 72	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327930&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650667	384582846							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644141	O=C(N1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C29H33N5O2/c35-28(33-17-13-31(14-18-33)22-24-7-3-1-4-8-24)26-11-12-27(30-21-26)29(36)34-19-15-32(16-20-34)23-25-9-5-2-6-10-25/h1-12,21H,13-20,22-23H2	HLMPLICAEPSBJM-UHFFFAOYSA-N	327931	US10377742, Compound 73::US9663496, Compound 73::pyridine-2,5-diylbis((4- benzylpiperazin-1- yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327931&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			4572076	384582847							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644142	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H35N5O2/c36-29(32-27-13-15-33(16-14-27)22-24-7-3-1-4-8-24)26-11-12-28(31-21-26)30(37)35-19-17-34(18-20-35)23-25-9-5-2-6-10-25/h1-12,21,27H,13-20,22-23H2,(H,32,36)	OOEKCGKFHYHSPV-UHFFFAOYSA-N	327932	6-(4-benzylpiperazine-1- carbonyl)-N-(1- benzylpiperidin-4- yl)nicotinamide::US10377742, Compound 74::US9663496, Compound 74	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327932&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073477	384582848							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644143	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C44H46N10O4/c45-25-31-1-5-33(6-2-31)29-51-17-13-37(14-18-51)49-41(55)39-11-9-35(27-47-39)43(57)53-21-23-54(24-22-53)44(58)36-10-12-40(48-28-36)42(56)50-38-15-19-52(20-16-38)30-34-7-3-32(26-46)4-8-34/h1-12,27-28,37-38H,13-24,29-30H2,(H,49,55)(H,50,56)	PQQKKQOBKNNYJV-UHFFFAOYSA-N	327933	5,5'-(piperazine-1,4- diylbis(oxomethylene))  bis(N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide)::US10377742, Compound 75::US9663496, Compound 75	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327933&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710375	384582849							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644144	Fc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31FN6O3/c32-26-8-5-24(6-9-26)30(40)37-15-17-38(18-16-37)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-36(14-12-27)21-23-3-1-22(19-33)2-4-23/h1-10,20,27H,11-18,21H2,(H,35,39)	RXZOTKZCZZFCCH-UHFFFAOYSA-N	327934	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 76::US9663496, Compound 76	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327934&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650668	384582850							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644145	COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-28-9-6-25(7-10-28)31(40)37-16-18-38(19-17-37)32(41)26-8-11-29(34-21-26)30(39)35-27-12-14-36(15-13-27)22-24-4-2-23(20-33)3-5-24/h2-11,21,27H,12-19,22H2,1H3,(H,35,39)	LXDHLOOAVAFEJF-UHFFFAOYSA-N	327935	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 77::US9663496, Compound 77	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327935&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650669	384582851							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644146	Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H31FN6O4S/c31-25-6-8-27(9-7-25)42(40,41)37-17-15-36(16-18-37)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-35(14-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,26H,11-18,21H2,(H,34,38)	MDZHPVWRGQFKCQ-UHFFFAOYSA-N	327936	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 78::US9663496, Compound 78	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327936&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651001	384582852							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644147	COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H34N6O5S/c1-42-27-7-9-28(10-8-27)43(40,41)37-18-16-36(17-19-37)31(39)25-6-11-29(33-21-25)30(38)34-26-12-14-35(15-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,26H,12-19,22H2,1H3,(H,34,38)	AVWVDLCYEHDFRA-UHFFFAOYSA-N	327937	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxyphenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 79::US9663496, Compound 79	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327937&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651002	384582853							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644148	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)c1ccccc1	InChI=1S/C31H32N6O3/c32-20-23-6-8-24(9-7-23)22-35-14-12-27(13-15-35)34-29(38)28-11-10-26(21-33-28)31(40)37-18-16-36(17-19-37)30(39)25-4-2-1-3-5-25/h1-11,21,27H,12-19,22H2,(H,34,38)	UZKLXKCSYXORTD-UHFFFAOYSA-N	327938	5-(4-benzoylpiperazine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 80::US9663496, Compound 80	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327938&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651003	384582854							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644149	CC(C)(C)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C29H36N6O3/c1-29(2,3)28(38)35-16-14-34(15-17-35)27(37)23-8-9-25(31-19-23)26(36)32-24-10-12-33(13-11-24)20-22-6-4-21(18-30)5-7-22/h4-9,19,24H,10-17,20H2,1-3H3,(H,32,36)	BYANCVXDXHRQLT-UHFFFAOYSA-N	327939	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- pivaloylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 81::US9663496, Compound 81	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327939&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651004	384582855							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644150	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccccc1	InChI=1S/C30H32N6O4S/c31-20-23-6-8-24(9-7-23)22-34-14-12-26(13-15-34)33-29(37)28-11-10-25(21-32-28)30(38)35-16-18-36(19-17-35)41(39,40)27-4-2-1-3-5-27/h1-11,21,26H,12-19,22H2,(H,33,37)	UFEIEYBIRIUWRQ-UHFFFAOYSA-N	327940	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(phenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 82::US9663496, Compound 82	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327940&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651005	384582856							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644151	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C1CCOCC1	InChI=1S/C29H36N6O3/c30-19-22-1-3-23(4-2-22)21-33-11-7-25(8-12-33)32-28(36)27-6-5-24(20-31-27)29(37)35-15-13-34(14-16-35)26-9-17-38-18-10-26/h1-6,20,25-26H,7-18,21H2,(H,32,36)	NMCSHUMJBBZUEI-UHFFFAOYSA-N	327941	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(tetrahydro-2H- pyran-4-yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 83::US9663496, Compound 83	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327941&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710517	384582857							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644152	CC(C)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C27H34N6O2/c1-20(2)32-13-15-33(16-14-32)27(35)23-7-8-25(29-18-23)26(34)30-24-9-11-31(12-10-24)19-22-5-3-21(17-28)4-6-22/h3-8,18,20,24H,9-16,19H2,1-2H3,(H,30,34)	SXPSAQUONWUCPN-UHFFFAOYSA-N	327942	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- isopropylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 84::US9663496, Compound 84	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327942&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710694	384582858							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644153	Cc1cc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)no1	InChI=1S/C28H34N6O3/c1-21-17-25(31-37-21)20-33-13-15-34(16-14-33)28(36)23-7-8-26(29-18-23)27(35)30-24-9-11-32(12-10-24)19-22-5-3-2-4-6-22/h2-8,17-18,24H,9-16,19-20H2,1H3,(H,30,35)	GWJLUAVBJOJUAI-UHFFFAOYSA-N	327943	N-(1-benzylpiperidin-4- yl)-5-(4-((5- methylisoxazol-3- yl)methyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 85::US9663496, Compound 85	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327943&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710206	384582859							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644154	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1cccc(n1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N7O2/c34-20-24-4-8-26(9-5-24)22-39-16-12-28(13-17-39)36-32(41)30-2-1-3-31(38-30)33(42)37-29-14-18-40(19-15-29)23-27-10-6-25(21-35)7-11-27/h1-11,28-29H,12-19,22-23H2,(H,36,41)(H,37,42)	ZNLOQOLMQYQXNI-UHFFFAOYSA-N	327944	N2,N6-bis(1-(4- cyanobenzyl)piperidin-4- yl)pyridine-2,6- dicarboxamide::US10377742, Compound 86::US9663496, Compound 86	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327944&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710797	384582860							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644155	Fc1ccc(CN2CCC(CC2)NC(=O)c2cccc(n2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35F2N5O2/c32-24-8-4-22(5-9-24)20-37-16-12-26(13-17-37)34-30(39)28-2-1-3-29(36-28)31(40)35-27-14-18-38(19-15-27)21-23-6-10-25(33)11-7-23/h1-11,26-27H,12-21H2,(H,34,39)(H,35,40)	RKTWPHQFWGVWFF-UHFFFAOYSA-N	327945	N2,N6-bis(1-(4- fluorobenzyl)piperidin- 4-yl)pyridine-2,6- dicarboxamide::US10377742, Compound 87::US9663496, Compound 87	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327945&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710631	384582861							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644156	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(CCc3ccccc3)CC2)cc1	InChI=1S/C30H34FN5O2/c31-27-9-6-25(7-10-27)23-34-16-20-35(21-17-34)29(37)26-8-11-28(32-22-26)30(38)36-18-14-33(15-19-36)13-12-24-4-2-1-3-5-24/h1-11,22H,12-21,23H2	UKCFFODPBLWFIW-UHFFFAOYSA-N	327946	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-3- yl)methanone::US10377742, Compound 88::US9663496, Compound 88	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327946&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073510	384582862							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644157	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)C1CCCCC1	InChI=1S/C31H38N6O3/c32-20-23-6-8-24(9-7-23)22-35-14-12-27(13-15-35)34-29(38)28-11-10-26(21-33-28)31(40)37-18-16-36(17-19-37)30(39)25-4-2-1-3-5-25/h6-11,21,25,27H,1-5,12-19,22H2,(H,34,38)	WFWVYMHDWSBWSD-UHFFFAOYSA-N	327947	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- (cyclohexanecarbonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 89::US9663496, Compound 89	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327947&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710780	384582863							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644158	O=C(N1CCN(CC1)c1ccccc1)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C29H33N5O2/c35-28(33-21-19-32(20-22-33)26-9-5-2-6-10-26)25-11-12-27(30-23-25)29(36)34-17-15-31(16-18-34)14-13-24-7-3-1-4-8-24/h1-12,23H,13-22H2	DILDXNXKQQSZDE-UHFFFAOYSA-N	327948	(4-phenethylpiperazin-1- yl)(5-(4- phenylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 90::US9663496, Compound 90	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327948&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073255	384582864							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644159	CC(C)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C26H35N5O2/c1-21(2)29-16-18-30(19-17-29)25(32)23-8-9-24(27-20-23)26(33)31-14-12-28(13-15-31)11-10-22-6-4-3-5-7-22/h3-9,20-21H,10-19H2,1-2H3	WELVWANXLGVWPI-UHFFFAOYSA-N	327949	(4-isopropylpiperazin-1- yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-3- yl)methanone::US10377742, Compound 91::US9663496, Compound 91	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327949&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073430	384582865							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644160	O=C(N1CCN(CCc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C31H37N5O2/c37-30(35-21-17-33(18-22-35)15-13-26-7-3-1-4-8-26)28-11-12-29(32-25-28)31(38)36-23-19-34(20-24-36)16-14-27-9-5-2-6-10-27/h1-12,25H,13-24H2	XIBAGROKRXXCJI-UHFFFAOYSA-N	327950	US10377742, Compound 92::US9663496, Compound 92::pyridine-2,5-diylbis((4- phenethylpiperazin-1- yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327950&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073439	384582866							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644161	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)N2CCN(CCc3ccccc3)CC2)cc1	InChI=1S/C30H34FN5O2/c31-26-11-9-25(10-12-26)23-34-17-21-36(22-18-34)30(38)28-8-4-7-27(32-28)29(37)35-19-15-33(16-20-35)14-13-24-5-2-1-3-6-24/h1-12H,13-23H2	KXOMWEWZJKBODO-UHFFFAOYSA-N	327956	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 93::US9663496, Compound 93	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327956&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073536	384582872							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644162	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)N2CCN(CC2)c2ccccc2)cc1	InChI=1S/C28H30FN5O2/c29-23-11-9-22(10-12-23)21-31-13-15-33(16-14-31)27(35)25-7-4-8-26(30-25)28(36)34-19-17-32(18-20-34)24-5-2-1-3-6-24/h1-12H,13-21H2	HOVNBOLMJBLKSZ-UHFFFAOYSA-N	327957	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 94::US9663496, Compound 94	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327957&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073228	384582873							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644163	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC2CCCCC2)CC1	InChI=1S/C31H40N6O2/c32-20-24-6-8-26(9-7-24)23-35-14-12-28(13-15-35)34-30(38)29-11-10-27(21-33-29)31(39)37-18-16-36(17-19-37)22-25-4-2-1-3-5-25/h6-11,21,25,28H,1-5,12-19,22-23H2,(H,34,38)	YJICAVIHOWJTJS-UHFFFAOYSA-N	327958	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- (cyclohexylmethyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 95::US9663496, Compound 95	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327958&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710462	384582874							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644164	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccncc1	InChI=1S/C28H32N6O2/c35-27(31-24-10-14-32(15-11-24)21-22-4-2-1-3-5-22)26-7-6-23(20-30-26)28(36)34-18-16-33(17-19-34)25-8-12-29-13-9-25/h1-9,12-13,20,24H,10-11,14-19,21H2,(H,31,35)	LZSZSQKOWNJKPK-UHFFFAOYSA-N	327959	N-(1-benzylpiperidin-4- yl)-5-(4-(pyridin-4- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 96::US9663496, Compound 96	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327959&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710310	384582875							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644165	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccccc1	InChI=1S/C29H33N5O2/c35-28(31-25-13-15-32(16-14-25)22-23-7-3-1-4-8-23)27-12-11-24(21-30-27)29(36)34-19-17-33(18-20-34)26-9-5-2-6-10-26/h1-12,21,25H,13-20,22H2,(H,31,35)	UHYHAUUNDGYPEZ-UHFFFAOYSA-N	327960	N-(1-benzylpiperidin-4- yl)-5-(4- phenylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 97::US9663496, Compound 97	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327960&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710805	384582876							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644166	CCOC(=O)C(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1	InChI=1S/C33H38FN5O4/c1-2-43-33(42)30(25-6-4-3-5-7-25)38-16-14-28(15-17-38)36-31(40)29-13-10-26(22-35-29)32(41)39-20-18-37(19-21-39)23-24-8-11-27(34)12-9-24/h3-13,22,28,30H,2,14-21,23H2,1H3,(H,36,40)	FKZQMJSSWXQOPZ-UHFFFAOYSA-N	327961	US10377742, Compound 98::US9663496, Compound 98::ethyl 2-(4-(5-(4-(4- fluorobenzyl)piperazine- 1- carbonyl)picolinamido)  piperidin-1-yl)-2- phenylacetate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327961&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710360	384582877							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644167	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)NC2CCC(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-27-12-8-26(9-13-27)22-37-16-18-38(19-17-37)32(40)30-3-1-2-29(36-30)31(39)35-28-14-10-24(11-15-28)20-23-4-6-25(21-34)7-5-23/h1-9,12-13,24,28H,10-11,14-20,22H2,(H,35,39)	DDXGSXLONGRSHS-UHFFFAOYSA-N	327962	N-(4-(4-cyanobenzyl)  cyclohexyl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 99::US9663496, Compound 99	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327962&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710673	384582878							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644168	F[C@H]1CN(Cc2ccc(cc2)C#N)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C31H32F2N6O2/c32-26-8-5-24(6-9-26)19-37-13-15-39(16-14-37)31(41)25-7-10-29(35-18-25)30(40)36-28-11-12-38(21-27(28)33)20-23-3-1-22(17-34)2-4-23/h1-10,18,27-28H,11-16,19-21H2,(H,36,40)/t27-,28+/m0/s1	GGMOGBNZFSCMDK-WUFINQPMSA-N	327963	US10377742, Compound 100::US9663496, Compound 100::cis-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327963&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084716	384582879							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644169	COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O3/c1-41-29-9-6-26(7-10-29)23-37-16-18-38(19-17-37)32(40)27-8-11-30(34-21-27)31(39)35-28-12-14-36(15-13-28)22-25-4-2-24(20-33)3-5-25/h2-11,21,28H,12-19,22-23H2,1H3,(H,35,39)	WPSUUXHDAQDYPG-UHFFFAOYSA-N	327964	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 101::US9663496, Compound 101	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327964&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710623	384582880							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644170	F[C@H]1CNCC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C23H27F2N5O2/c24-18-4-1-16(2-5-18)15-29-9-11-30(12-10-29)23(32)17-3-6-21(27-13-17)22(31)28-20-7-8-26-14-19(20)25/h1-6,13,19-20,26H,7-12,14-15H2,(H,28,31)/t19-,20+/m0/s1	SSXKELDQHCLBAC-VQTJNVASSA-N	327965	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(cis-3- fluoropiperidin-4- yl)picolinamide::US10377742, Compound 102::US9663496, Compound 102	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327965&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710572	384582881							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644171	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccncc2)CC1	InChI=1S/C30H33N7O2/c31-19-23-1-3-24(4-2-23)21-35-13-9-27(10-14-35)34-29(38)28-6-5-26(20-33-28)30(39)37-17-15-36(16-18-37)22-25-7-11-32-12-8-25/h1-8,11-12,20,27H,9-10,13-18,21-22H2,(H,34,38)	RMUCYZDCFKRSNY-UHFFFAOYSA-N	327966	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(pyridin-4- ylmethyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 103::US9663496, Compound 103	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327966&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710289	384582882							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644172	F[C@H]1CN(Cc2ccncc2)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C29H32F2N6O2/c30-24-4-1-21(2-5-24)18-35-13-15-37(16-14-35)29(39)23-3-6-27(33-17-23)28(38)34-26-9-12-36(20-25(26)31)19-22-7-10-32-11-8-22/h1-8,10-11,17,25-26H,9,12-16,18-20H2,(H,34,38)/t25-,26+/m0/s1	KMRPXMWIZLSCAG-IZZNHLLZSA-N	327967	N-(cis-3-fluoro-1- (pyridin-4- ylmethyl)piperidin-4-yl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 104::US9663496, Compound 104	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327967&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710307	384582883							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644173	O=C(Nc1ccc(cc1)-c1ccccc1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H30N4O2/c36-30(33-27-14-11-25(12-15-27)24-9-5-2-6-10-24)26-13-16-29(32-21-26)31(37)34-28-17-19-35(20-18-28)22-23-7-3-1-4-8-23/h1-16,21,28H,17-20,22H2,(H,33,36)(H,34,37)	CWIOPRLBOMZPKA-UHFFFAOYSA-N	327968	N2-(1-benzylpiperidin-4- yl)-N5-(biphenyl-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 105::US9663496, Compound 105	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327968&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710362	384582884							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644174	O=C(Nc1cccc(c1)-c1ccccc1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H30N4O2/c36-30(34-28-13-7-12-25(20-28)24-10-5-2-6-11-24)26-14-15-29(32-21-26)31(37)33-27-16-18-35(19-17-27)22-23-8-3-1-4-9-23/h1-15,20-21,27H,16-19,22H2,(H,33,37)(H,34,36)	RUQCHWUZRNYFAS-UHFFFAOYSA-N	327969	N2-(1-benzylpiperidin-4- yl)-N5-(biphenyl-3- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 106::US9663496, Compound 106	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327969&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710236	384582885							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644175	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2)cc1	InChI=1S/C24H23FN4O2/c25-20-9-6-18(7-10-20)17-28-12-14-29(15-13-28)24(31)19-8-11-22(26-16-19)23(30)27-21-4-2-1-3-5-21/h1-11,16H,12-15,17H2,(H,27,30)	VLEVKLAKDLKCFK-UHFFFAOYSA-N	327970	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N- phenylpicolinamide::US10377742, Compound 107::US9663496, Compound 107	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327970&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710223	384582886							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644176	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)c1ccc(Cc2ccccc2)cc1	InChI=1S/C33H30N4O2/c34-21-26-6-8-27(9-7-26)23-37-18-16-30(17-19-37)36-33(39)31-15-14-29(22-35-31)32(38)28-12-10-25(11-13-28)20-24-4-2-1-3-5-24/h1-15,22,30H,16-20,23H2,(H,36,39)	JVHKOFNXLVBDAK-UHFFFAOYSA-N	327971	5-(4- benzylphenylamino)-N- (1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US9663496, Compound 108	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327971&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486199	384582887							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644177	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Nc2ccc(cc2)-c2ccccc2)cn1	InChI=1S/C31H29N5O/c32-20-23-6-8-24(9-7-23)22-36-18-16-28(17-19-36)35-31(37)30-15-14-29(21-33-30)34-27-12-10-26(11-13-27)25-4-2-1-3-5-25/h1-15,21,28,34H,16-19,22H2,(H,35,37)	XECSTZQZWRCGSO-UHFFFAOYSA-N	327972	5-(biphenyl-4-ylamino)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 109::US9663496, Compound 109	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327972&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710499	384582888							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644178	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H34N6O/c31-20-24-6-8-26(9-7-24)23-34-14-12-27(13-15-34)33-30(37)29-11-10-28(21-32-29)36-18-16-35(17-19-36)22-25-4-2-1-3-5-25/h1-11,21,27H,12-19,22-23H2,(H,33,37)	TUXSVDQMBSARPI-UHFFFAOYSA-N	327973	5-(4-benzylpiperazin-1- yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 110::US9663496, Compound 110	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327973&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710221	384582889							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644179	CC(C)(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccc(cc1)C#N	InChI=1S/C33H37FN6O2/c1-33(2,27-8-3-24(21-35)4-9-27)40-15-13-29(14-16-40)37-31(41)30-12-7-26(22-36-30)32(42)39-19-17-38(18-20-39)23-25-5-10-28(34)11-6-25/h3-12,22,29H,13-20,23H2,1-2H3,(H,37,41)	PJUPLDXIIBQNBZ-UHFFFAOYSA-N	327974	N-(1-(2-(4- cyanophenyl)propan-2- yl)piperidin-4-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 111::US9663496, Compound 111	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327974&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710432	384582890							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644180	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2cccc(Oc3ccccc3)c2)cn1	InChI=1S/C30H30N4O2/c35-30(33-24-16-18-34(19-17-24)22-23-8-3-1-4-9-23)29-15-14-26(21-31-29)32-25-10-7-13-28(20-25)36-27-11-5-2-6-12-27/h1-15,20-21,24,32H,16-19,22H2,(H,33,35)	SIUGKYLYXCIBJK-UHFFFAOYSA-N	327975	N-(1-benzylpiperidin-4- yl)-5-(3- phenoxyphenylamino)  picolinamide::US10377742, Compound 112::US9663496, Compound 112	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327975&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710737	384582891							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644181	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2ccc(Oc3ccccc3)cc2)cn1	InChI=1S/C30H30N4O2/c35-30(33-25-17-19-34(20-18-25)22-23-7-3-1-4-8-23)29-16-13-26(21-31-29)32-24-11-14-28(15-12-24)36-27-9-5-2-6-10-27/h1-16,21,25,32H,17-20,22H2,(H,33,35)	DBXTZCORMIZYNR-UHFFFAOYSA-N	327976	N-(1-benzylpiperidin-4- yl)-5-(4- phenoxyphenylamino)  picolinamide::US10377742, Compound 113::US9663496, Compound 113	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327976&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710621	384582892							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644182	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2cccc(c2)-c2ccccc2)cn1	InChI=1S/C30H30N4O/c35-30(33-26-16-18-34(19-17-26)22-23-8-3-1-4-9-23)29-15-14-28(21-31-29)32-27-13-7-12-25(20-27)24-10-5-2-6-11-24/h1-15,20-21,26,32H,16-19,22H2,(H,33,35)	ALWPRGJHZOZRBU-UHFFFAOYSA-N	327977	N-(1-benzylpiperidin-4- yl)-5-(biphenyl-3- ylamino)picolinamide::US10377742, Compound 114::US9663496, Compound 114	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327977&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710249	384582893							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644183	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NCc2ccccc2)cc1	InChI=1S/C25H25FN4O2/c26-22-9-6-20(7-10-22)18-29-12-14-30(15-13-29)25(32)21-8-11-23(27-17-21)24(31)28-16-19-4-2-1-3-5-19/h1-11,17H,12-16,18H2,(H,28,31)	SFBUXGKMWDVQSW-UHFFFAOYSA-N	327978	N-benzyl-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 115::US9663496, Compound 115	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327978&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710681	384582894							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644184	O=C(NCc1ccccc1)c1ccc(cn1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C25H26N4O2/c30-24(27-17-20-7-3-1-4-8-20)23-12-11-22(18-26-23)25(31)29-15-13-28(14-16-29)19-21-9-5-2-6-10-21/h1-12,18H,13-17,19H2,(H,27,30)	LYNNCHNXFHBVFJ-UHFFFAOYSA-N	327979	N-benzyl-5-(4- benzylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 116::US9663496, Compound 116	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327979&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710498	384582895							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644185	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H36FN5O3/c1-40-28-9-4-24(5-10-28)21-35-14-12-27(13-15-35)34-30(38)29-11-6-25(20-33-29)31(39)37-18-16-36(17-19-37)22-23-2-7-26(32)8-3-23/h2-11,20,27H,12-19,21-22H2,1H3,(H,34,38)	JBOAVLPHPAENSA-UHFFFAOYSA-N	327980	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 117::US9663496, Compound 117	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327980&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710497	384582896							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644186	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(cc3)C#N)C2)cc1	InChI=1S/C30H31FN6O2/c31-26-8-5-24(6-9-26)19-35-13-15-37(16-14-35)30(39)25-7-10-28(33-18-25)29(38)34-27-11-12-36(21-27)20-23-3-1-22(17-32)2-4-23/h1-10,18,27H,11-16,19-21H2,(H,34,38)/t27-/m1/s1	ZTMNZDLYLCMZAQ-HHHXNRCGSA-N	327981	(R)-N-(1-(4- cyanobenzyl)pyrrolidin- 3-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 118::US9663496, Compound 118	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327981&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710214	384582897							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644187	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2ccc(cc2)-c2ccc(cc2)C#N)cn1	InChI=1S/C31H29N5O/c32-20-23-6-8-25(9-7-23)26-10-12-27(13-11-26)34-29-14-15-30(33-21-29)31(37)35-28-16-18-36(19-17-28)22-24-4-2-1-3-5-24/h1-15,21,28,34H,16-19,22H2,(H,35,37)	BRQNXRPRXREDNU-UHFFFAOYSA-N	327982	N-(1-benzylpiperidin-4- yl)-5-(4'-cyanobiphenyl- 4-ylamino)picolinamide::US9663496, Compound 119	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327982&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710316	384582898							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644188	COc1ccc(cc1)-c1ccc(Nc2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	InChI=1S/C31H32N4O2/c1-37-29-14-9-25(10-15-29)24-7-11-26(12-8-24)33-28-13-16-30(32-21-28)31(36)34-27-17-19-35(20-18-27)22-23-5-3-2-4-6-23/h2-16,21,27,33H,17-20,22H2,1H3,(H,34,36)	YAMQWOAVLNMDPS-UHFFFAOYSA-N	327983	N-(1-benzylpiperidin-4- yl)-5-(4'- methoxybiphenyl-4- ylamino)picolinamide::US10377742, Compound 120::US9663496, Compound 120	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327983&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710250	384582899							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644189	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)-c1cn(Cc2ccccc2)nn1	InChI=1S/C28H27N7O/c29-16-21-6-8-23(9-7-21)18-34-14-12-25(13-15-34)31-28(36)26-11-10-24(17-30-26)27-20-35(33-32-27)19-22-4-2-1-3-5-22/h1-11,17,20,25H,12-15,18-19H2,(H,31,36)	WSQFHPOHNFIYFY-UHFFFAOYSA-N	327984	5-(1-benzyl-1H-1,2,3- triazol-4-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 121::US9663496, Compound 121	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327984&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710438	384582900							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644190	Fc1ccc(CN2CCN(CC2=O)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	InChI=1S/C30H32FN5O3/c31-25-9-6-23(7-10-25)20-35-16-17-36(21-28(35)37)30(39)24-8-11-27(32-18-24)29(38)33-26-12-14-34(15-13-26)19-22-4-2-1-3-5-22/h1-11,18,26H,12-17,19-21H2,(H,33,38)	YNMMLVPNDUXLQQ-UHFFFAOYSA-N	327985	5-(1-benzyl-1H-1,2,3- triazol-4-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 122::US9663496, Compound 122	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327985&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084719	384582901							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644191	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CCN(Cc3ccc(cc3)C#N)C2)cc1	InChI=1S/C30H31FN6O2/c31-26-8-5-24(6-9-26)19-35-13-15-37(16-14-35)30(39)25-7-10-28(33-18-25)29(38)34-27-11-12-36(21-27)20-23-3-1-22(17-32)2-4-23/h1-10,18,27H,11-16,19-21H2,(H,34,38)/t27-/m0/s1	ZTMNZDLYLCMZAQ-MHZLTWQESA-N	327986	(S)-N-(1-(4- cyanobenzyl)pyrrolidin- 3-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US9663496, Compound 123	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327986&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710331	384582902							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644192	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C31H34N6O2/c32-20-24-6-8-26(9-7-24)23-35-14-12-28(13-15-35)34-30(38)29-11-10-27(21-33-29)31(39)37-18-16-36(17-19-37)22-25-4-2-1-3-5-25/h1-11,21,28H,12-19,22-23H2,(H,34,38)	YIZJRCUHRRDTDD-UHFFFAOYSA-N	327987	5-(4-benzylpiperidine-1- carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US9663496, Compound 124	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327987&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486200	384582903							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644193	CC1(C)CN(CCN1Cc1ccc(F)cc1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H37FN6O2/c1-33(2)23-39(17-18-40(33)22-26-7-10-28(34)11-8-26)32(42)27-9-12-30(36-20-27)31(41)37-29-13-15-38(16-14-29)21-25-5-3-24(19-35)4-6-25/h3-12,20,29H,13-18,21-23H2,1-2H3,(H,37,41)	CCVJKVSSPUWIOG-UHFFFAOYSA-N	327988	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzyl)-3,3- dimethylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 125::US9663496, Compound 125	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327988&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710341	384582904							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644194	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(NC2CCN(CC2)c2ccccc2)cn1	InChI=1S/C30H34N6O/c31-20-23-6-8-24(9-7-23)22-35-16-12-26(13-17-35)34-30(37)29-11-10-27(21-32-29)33-25-14-18-36(19-15-25)28-4-2-1-3-5-28/h1-11,21,25-26,33H,12-19,22H2,(H,34,37)	CQIGWVFBNAADFU-UHFFFAOYSA-N	327989	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-phenylpiperidin- 4-ylamino)picolinamide::US10377742, Compound 126::US9663496, Compound 126	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327989&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710671	384582905							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644195	F[C@H]1CN(Cc2ccc(Cl)cc2)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H32ClF2N5O2/c31-24-6-1-21(2-7-24)19-37-12-11-27(26(33)20-37)35-29(39)28-10-5-23(17-34-28)30(40)38-15-13-36(14-16-38)18-22-3-8-25(32)9-4-22/h1-10,17,26-27H,11-16,18-20H2,(H,35,39)/t26-,27+/m0/s1	QFCGCJFUXOLOOW-RRPNLBNLSA-N	327990	N-(cis-1-(4- chlorobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 127::US9663496, Compound 127	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327990&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710363	384582906							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644196	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H34N6O2/c34-20-26-3-1-24(2-4-26)19-25-11-17-39(18-12-25)33(41)29-9-10-31(36-22-29)32(40)37-30-13-15-38(16-14-30)23-28-7-5-27(21-35)6-8-28/h1-10,22,25,30H,11-19,23H2,(H,37,40)	MRMDURIHTGUZQI-UHFFFAOYSA-N	327991	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 128::US9663496, Compound 128	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327991&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710600	384582907							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644197	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	POEZYVXOVVWICH-UHFFFAOYSA-N	327992	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 129::US9663496, Compound 129	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327992&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710523	384582908							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644198	Fc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-28-8-5-23(6-9-28)19-24-11-17-38(18-12-24)32(40)27-7-10-30(35-21-27)31(39)36-29-13-15-37(16-14-29)22-26-3-1-25(20-34)2-4-26/h1-10,21,24,29H,11-19,22H2,(H,36,39)	NDMQOBJALHHUBI-UHFFFAOYSA-N	327993	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 130::US9663496, Compound 130	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327993&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710624	384582909							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644199	COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H37N5O3/c1-41-30-9-6-24(7-10-30)20-25-12-18-38(19-13-25)33(40)28-8-11-31(35-22-28)32(39)36-29-14-16-37(17-15-29)23-27-4-2-26(21-34)3-5-27/h2-11,22,25,29H,12-20,23H2,1H3,(H,36,39)	CXYVYGXMFQSTKH-UHFFFAOYSA-N	327994	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 131::US9663496, Compound 131	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327994&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710649	384582910							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644200	Fc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc3CCN(Cc4ccc(cc4)C#N)Cc3c2)cc1	InChI=1S/C36H34FN5O2/c37-32-9-5-25(6-10-32)19-26-13-17-42(18-14-26)36(44)30-8-12-34(39-22-30)35(43)40-33-11-7-29-15-16-41(24-31(29)20-33)23-28-3-1-27(21-38)2-4-28/h1-12,20,22,26H,13-19,23-24H2,(H,40,43)	UMVLFDRMEJXDJL-UHFFFAOYSA-N	327995	N-(2-(4-cyanobenzyl)- 1,2,3,4- tetrahydroisoquinolin-7- yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US9663496, Compound 132	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327995&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486201	384582911							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644201	CC(C)(N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccccc1	InChI=1S/C33H38N6O2/c1-33(2,28-6-4-3-5-7-28)39-20-18-38(19-21-39)32(41)27-12-13-30(35-23-27)31(40)36-29-14-16-37(17-15-29)24-26-10-8-25(22-34)9-11-26/h3-13,23,29H,14-21,24H2,1-2H3,(H,36,40)	ANTKASWXMLJFBB-UHFFFAOYSA-N	327996	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2- phenylpropan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 133::US9663496, Compound 133	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327996&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710761	384582912							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644202	Clc1ccc(cc1)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32ClN5O2/c32-27-8-5-24(6-9-27)25-11-17-37(18-12-25)31(39)26-7-10-29(34-20-26)30(38)35-28-13-15-36(16-14-28)21-23-3-1-22(19-33)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,35,38)	IDMGMBXNNCRUAB-UHFFFAOYSA-N	327997	5-(4-(4- chlorophenyl)piperidine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 134::US9663496, Compound 134	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327997&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710528	384582913							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644203	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-26(21-35-30)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)	BPMMMRKHRUQAAY-UHFFFAOYSA-N	327998	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 135::US9663496, Compound 135	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327998&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710291	384582914							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644204	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32FN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,36,40)	QZCUYXGDXFPQEA-UHFFFAOYSA-N	327999	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 136::US9663496, Compound 136	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327999&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710317	384582915							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644205	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCCC(C1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-18-23-3-5-25(6-4-23)21-37-16-13-27(14-17-37)36-31(39)30-12-9-26(20-35-30)32(40)38-15-1-2-29(22-38)41-28-10-7-24(19-34)8-11-28/h3-12,20,27,29H,1-2,13-17,21-22H2,(H,36,39)	WJFHULPMCHGBBX-UHFFFAOYSA-N	328000	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 137::US9663496, Compound 137	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328000&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710280	384582916							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644206	FC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1	InChI=1S/C32H33F2N5O2/c33-27-8-5-24(6-9-27)30(34)25-11-17-39(18-12-25)32(41)26-7-10-29(36-20-26)31(40)37-28-13-15-38(16-14-28)21-23-3-1-22(19-35)2-4-23/h1-10,20,25,28,30H,11-18,21H2,(H,37,40)	FJNHSBVZTQFKEF-UHFFFAOYSA-N	328001	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro(4- fluorophenyl)methyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 138::US9663496, Compound 138	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328001&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710312	384582917							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644207	Clc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H33ClN6O/c31-24-5-8-28(9-6-24)37-17-13-25(14-18-37)34-27-7-10-29(33-20-27)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,25-26,34H,11-18,21H2,(H,35,38)	AUDCQJXZPQEOHW-UHFFFAOYSA-N	328002	5-(1-(4- chlorophenyl)piperidin- 4-ylamino)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 139::US9663496, Compound 139	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328002&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710586	384582918							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644208	Fc1cc(F)cc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C31H32F2N6O2/c32-26-15-24(16-27(33)17-26)21-38-11-13-39(14-12-38)31(41)25-5-6-29(35-19-25)30(40)36-28-7-9-37(10-8-28)20-23-3-1-22(18-34)2-4-23/h1-6,15-17,19,28H,7-14,20-21H2,(H,36,40)	PXNMSZNSQODFJQ-UHFFFAOYSA-N	328003	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,5- difluorobenzyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 140::US9663496, Compound 140	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328003&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710477	384582919							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644209	NC(=O)c1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H36N6O3/c34-20-25-1-3-26(4-2-25)22-38-15-13-29(14-16-38)37-32(41)30-10-9-28(21-36-30)33(42)39-17-11-24(12-18-39)19-23-5-7-27(8-6-23)31(35)40/h1-10,21,24,29H,11-19,22H2,(H2,35,40)(H,37,41)	VEVULXHDAOOWBK-UHFFFAOYSA-N	328004	5-(4-(4- carbamoylbenzyl)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US9663496, Compound 141	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328004&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710256	384582920							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644210	OC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1	InChI=1S/C32H34FN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28,30,39H,11-18,21H2,(H,36,40)	WNLKAYDTKKISBN-UHFFFAOYSA-N	328005	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-((4- fluorophenyl)(hydroxy)  methyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 142::US9663496, Compound 142	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328005&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710385	384582921							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644211	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-9-28(10-8-27)41-29-14-18-37(19-15-29)32(39)25-6-11-30(34-21-25)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	OFPXCBKYWWZZGT-UHFFFAOYSA-N	328006	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 143::US9663496, Compound 143	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328006&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710345	384582922							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644212	Fc1ccc(CNC(=O)c2ccc(nc2)C(=O)Nc2ccc3CCN(Cc4ccc(cc4)C#N)Cc3c2)cc1	InChI=1S/C31H26FN5O2/c32-27-9-5-22(6-10-27)17-35-30(38)25-8-12-29(34-18-25)31(39)36-28-11-7-24-13-14-37(20-26(24)15-28)19-23-3-1-21(16-33)2-4-23/h1-12,15,18H,13-14,17,19-20H2,(H,35,38)(H,36,39)	NAUIMQDUCLBJRJ-UHFFFAOYSA-N	328007	N2-(2-(4-cyanobenzyl)- 1,2,3,4- tetrahydroisoquinolin-7- yl)-N5-(4- fluorobenzyl)pyridine- 2,5-dicarboxamide::US10377742, Compound 144::US9663496, Compound 144	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328007&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710257	384582923							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644213	Cc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H37N5O2/c1-24-2-4-25(5-3-24)20-26-12-18-38(19-13-26)33(40)29-10-11-31(35-22-29)32(39)36-30-14-16-37(17-15-30)23-28-8-6-27(21-34)7-9-28/h2-11,22,26,30H,12-20,23H2,1H3,(H,36,39)	GAXYQFRRJQSHAN-UHFFFAOYSA-N	328008	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methylbenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 145::US9663496, Compound 145	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328008&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710568	384582924							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644214	COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1F	InChI=1S/C33H36FN5O3/c1-42-31-9-6-26(19-29(31)34)18-23-10-16-39(17-11-23)33(41)27-7-8-30(36-21-27)32(40)37-28-12-14-38(15-13-28)22-25-4-2-24(20-35)3-5-25/h2-9,19,21,23,28H,10-18,22H2,1H3,(H,37,40)	XGUKVBQSHUARJJ-UHFFFAOYSA-N	328009	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3-fluoro-4- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 146::US9663496, Compound 146	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328009&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710532	384582925							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644215	COc1cccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C33H37N5O3/c1-41-30-4-2-3-27(20-30)19-24-11-17-38(18-12-24)33(40)28-9-10-31(35-22-28)32(39)36-29-13-15-37(16-14-29)23-26-7-5-25(21-34)6-8-26/h2-10,20,22,24,29H,11-19,23H2,1H3,(H,36,39)	SBPPXQVCQDZTHN-UHFFFAOYSA-N	328010	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 147::US9663496, Compound 147	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328010&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710487	384582926							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644216	Fc1ccc(OCCNC(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C28H28FN5O3/c29-23-6-8-25(9-7-23)37-16-13-31-27(35)22-5-10-26(32-18-22)28(36)33-24-11-14-34(15-12-24)19-21-3-1-20(17-30)2-4-21/h1-10,18,24H,11-16,19H2,(H,31,35)(H,33,36)	DENRPACRNJYZDG-UHFFFAOYSA-N	328011	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(2-(4- fluorophenoxy)ethyl)  pyridine-2,5- dicarboxamide::US10377742, Compound 149::US9663496, Compound 149	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328011&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710539	384582927							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644217	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)24-5-14-29(34-20-24)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-7,10-11,14,20,26,28H,8-9,12-13,15-18,21H2,(H,35,38)/t26-,28+	GIQKDCHBWREEQP-DBAYTGFXSA-N	328012	N-(cis-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 150::US9663496, Compound 150	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328012&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650666	384582928							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644218	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31FN4O4/c33-25-6-3-22(4-7-25)30(38)23-15-17-37(18-16-23)32(40)24-5-14-29(35-20-24)31(39)36-26-8-12-28(13-9-26)41-27-10-1-21(19-34)2-11-27/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,36,39)/t26-,28+	KILULKZXXSWNCI-DBAYTGFXSA-N	328013	N-(trans-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 151::US9663496, Compound 151	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328013&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073275	384582929							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644219	Fc1ccc(CC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-28-10-7-23(8-11-28)18-26-2-1-15-38(22-26)32(40)27-9-12-30(35-20-27)31(39)36-29-13-16-37(17-14-29)21-25-5-3-24(19-34)4-6-25/h3-12,20,26,29H,1-2,13-18,21-22H2,(H,36,39)	SWDLJAZQRMNAGX-UHFFFAOYSA-N	328014	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 152::US9663496, Compound 152	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328014&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710625	384582930							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644220	Fc1ccc(CC2CCCCN2C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-27-11-8-23(9-12-27)19-29-3-1-2-16-38(29)32(40)26-10-13-30(35-21-26)31(39)36-28-14-17-37(18-15-28)22-25-6-4-24(20-34)5-7-25/h4-13,21,28-29H,1-3,14-19,22H2,(H,36,39)	KABCVIPOCMQHMB-UHFFFAOYSA-N	328015	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(2-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 153::US9663496, Compound 153	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328015&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710460	384582931							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644221	Clc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32ClN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,36,40)	AKNRXDGPROARKE-UHFFFAOYSA-N	328016	5-(4-(4-chlorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 154::US9663496, Compound 154	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328016&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710303	384582932							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644222	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1cccc(c1)C#N	InChI=1S/C32H32N6O3/c33-19-23-4-6-24(7-5-23)22-37-14-10-27(11-15-37)36-31(39)30-9-8-26(21-35-30)32(40)38-16-12-28(13-17-38)41-29-3-1-2-25(18-29)20-34/h1-9,18,21,27-28H,10-17,22H2,(H,36,39)	FGBIWVHUOKXSKR-UHFFFAOYSA-N	328017	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 155::US9663496, Compound 155	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328017&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710793	384582933							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644223	Clc1cc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)ccc1C#N	InChI=1S/C32H31ClN6O3/c33-29-17-28(7-5-24(29)19-35)42-27-11-15-39(16-12-27)32(41)25-6-8-30(36-20-25)31(40)37-26-9-13-38(14-10-26)21-23-3-1-22(18-34)2-4-23/h1-8,17,20,26-27H,9-16,21H2,(H,37,40)	GLIPJVAVLQRNNM-UHFFFAOYSA-N	328018	5-(4-(3-chloro-4- cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 156::US9663496, Compound 156	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328018&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710305	384582934							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644224	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O3/c33-32(34,35)25-6-8-27(9-7-25)43-28-13-17-40(18-14-28)31(42)24-5-10-29(37-20-24)30(41)38-26-11-15-39(16-12-26)21-23-3-1-22(19-36)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,38,41)	SWFYJWRPKQUXJE-UHFFFAOYSA-N	328019	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 157::US9663496, Compound 157	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328019&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710652	384582935							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644225	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1F	InChI=1S/C31H31F2N5O3/c32-27-7-6-26(17-28(27)33)41-25-11-15-38(16-12-25)31(40)23-5-8-29(35-19-23)30(39)36-24-9-13-37(14-10-24)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,24-25H,9-16,20H2,(H,36,39)	BUTSOOYTBYLGPV-UHFFFAOYSA-N	328020	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 158::US9663496, Compound 158	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328020&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710554	384582936							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644226	Fc1ccc(CN2CCN(CC2)C(=O)c2cnc(C(=O)NC3CCN(Cc4ccc(cc4)C#N)CC3)c(c2)C#CCNC(=O)COCCOCCOCCOCCNC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1	InChI=1S/C54H69FN10O9S/c55-44-13-11-41(12-14-44)36-64-21-23-65(24-22-64)53(69)43-32-42(50(59-34-43)52(68)60-45-15-19-63(20-16-45)35-40-9-7-39(33-56)8-10-40)4-3-17-57-49(67)37-74-31-30-73-29-28-72-27-26-71-25-18-58-48(66)6-2-1-5-47-51-46(38-75-47)61-54(70)62-51/h7-14,32,34,45-47,51H,1-2,5-6,15-31,35-38H2,(H,57,67)(H,58,66)(H,60,68)(H2,61,62,70)/t46?,47-,51?/m0/s1	FWJRFHYFNIIOBV-FVWFCGMMSA-N	328021	N-(1-(4- cyanobenzyl)piperidin-4- yl)-3-(5,20-dioxo-24- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-7,10,13,16-tetraoxa- 4,19-diazatetracos-1- ynyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 159::US9663496, Compound 159	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328021&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486202	384582937							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644227	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1	InChI=1S/C32H35FN4O4/c1-41-28-9-2-22(3-10-28)21-36-16-14-27(15-17-36)35-31(39)29-11-6-25(20-34-29)32(40)37-18-12-24(13-19-37)30(38)23-4-7-26(33)8-5-23/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	KXKXMISUTNBPTD-UHFFFAOYSA-N	328022	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 160::US9663496, Compound 160	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328022&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710693	384582938							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644228	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C31H35FN4O4/c1-39-26-7-2-22(3-8-26)21-35-16-12-25(13-17-35)34-30(37)29-11-4-23(20-33-29)31(38)36-18-14-28(15-19-36)40-27-9-5-24(32)6-10-27/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	GQLHMTROMKDTKQ-UHFFFAOYSA-N	328023	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 161::US9663496, Compound 161	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328023&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710672	384582939							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644229	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-4-24(5-8-27)22-36-16-12-26(13-17-36)35-31(38)30-11-6-25(21-34-30)32(39)37-18-14-29(15-19-37)41-28-9-2-23(20-33)3-10-28/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	AAZRKTXOGFHLEO-UHFFFAOYSA-N	328024	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 162::US9663496, Compound 162	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328024&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710427	384582940							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644230	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C33H38N4O5/c1-41-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)30-12-7-26(21-34-30)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(42-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	DTAVECBCQBGUGF-UHFFFAOYSA-N	328025	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 163::US9663496, Compound 163	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328025&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710233	384582941							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644231	CC(C)(C)OC(=O)NCC#Cc1cc(cnc1C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C39H44FN7O4/c1-39(2,3)51-38(50)42-16-4-5-31-23-32(37(49)47-21-19-46(20-22-47)27-30-10-12-33(40)13-11-30)25-43-35(31)36(48)44-34-14-17-45(18-15-34)26-29-8-6-28(24-41)7-9-29/h6-13,23,25,34H,14-22,26-27H2,1-3H3,(H,42,50)(H,44,48)	MUQUTLCBPZXGBA-UHFFFAOYSA-N	328026	US10377742, Compound 164::US9663496, Compound 164::tert-butyl 3-(2-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-3- yl)prop-2-ynylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328026&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710606	384582942							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644232	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H32N6O2/c32-19-23-1-3-25(4-2-23)22-36-15-11-26(12-16-36)35-31(38)30-10-7-27(21-34-30)37-17-13-29(14-18-37)39-28-8-5-24(20-33)6-9-28/h1-10,21,26,29H,11-18,22H2,(H,35,38)	RMRAPVQTYURKPZ-UHFFFAOYSA-N	328027	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenoxy)piperidin- 1-yl)picolinamide::US10377742, Compound 165::US9663496, Compound 165	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328027&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710718	384582943							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644233	O=C(NC1CCN(CC1)c1ccc(cc1)C#N)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H33N7O2/c33-19-23-1-3-25(4-2-23)22-38-15-11-27(12-16-38)37-32(41)30-10-7-26(21-35-30)31(40)36-28-13-17-39(18-14-28)29-8-5-24(20-34)6-9-29/h1-10,21,27-28H,11-18,22H2,(H,36,40)(H,37,41)	PYLAIZRZOYDMDH-UHFFFAOYSA-N	328028	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5 -(1-(4- cyanophenyl)piperidin- 4-yl)pyridine-2,5- dicarboxamide::US10377742, Compound 166::US9663496, Compound 166	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328028&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710367	384582944							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644234	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)40-28-15-17-36(18-16-28)31(38)22-3-14-29(34-20-22)30(37)35-24-6-12-27(13-7-24)39-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27+	BZCVQNXMJJLXPG-FEGDYQJNSA-N	328029	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 167::US9663496, Compound 167	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328029&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073475	384582945							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644235	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31FN4O4/c33-25-6-3-22(4-7-25)30(38)23-15-17-37(18-16-23)32(40)24-5-14-29(35-20-24)31(39)36-26-8-12-28(13-9-26)41-27-10-1-21(19-34)2-11-27/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,36,39)/t26-,28-	KILULKZXXSWNCI-FBSWEULCSA-N	328030	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 168::US9663496, Compound 168	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328030&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073275	384582946							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644236	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)40-28-15-17-36(18-16-28)31(38)22-3-14-29(34-20-22)30(37)35-24-6-12-27(13-7-24)39-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27-	BZCVQNXMJJLXPG-HNKWHGCMSA-N	328031	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 169::US9663496, Compound 169	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328031&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073475	384582947							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644237	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC(=O)c3ccc(cc3)-c3ccccc3)nc2)cc1	InChI=1S/C30H27FN4O2/c31-27-13-6-22(7-14-27)21-34-16-18-35(19-17-34)30(37)26-12-15-28(32-20-26)33-29(36)25-10-8-24(9-11-25)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,32,33,36)	RVMRUZKLKWZPBU-UHFFFAOYSA-N	328032	N-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2- yl)biphenyl-4- carboxamide::US10377742, Compound 170::US9663496, Compound 170	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328032&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710824	384582948							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644238	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C33H34N4O5/c1-41-27-11-4-23(5-12-27)31(38)24-16-18-37(19-17-24)33(40)25-6-15-30(35-21-25)32(39)36-26-7-13-29(14-8-26)42-28-9-2-22(20-34)3-10-28/h2-6,9-12,15,21,24,26,29H,7-8,13-14,16-19H2,1H3,(H,36,39)/t26-,29+	DXFJCXIKMLXEJV-RWDNANMHSA-N	328033	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 171::US9663496, Compound 171	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328033&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710361	384582949							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644239	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O5/c1-39-25-11-13-28(14-12-25)41-29-16-18-36(19-17-29)32(38)23-4-15-30(34-21-23)31(37)35-24-5-9-27(10-6-24)40-26-7-2-22(20-33)3-8-26/h2-4,7-8,11-15,21,24,27,29H,5-6,9-10,16-19H2,1H3,(H,35,37)/t24-,27-	QVGHVUBOGYEDKB-HNKWHGCMSA-N	328034	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 172::US9663496, Compound 172	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328034&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710218	384582950							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644240	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(NC(=O)C3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1	InChI=1S/C31H32FN5O3/c32-26-6-8-27(9-7-26)40-28-13-17-37(18-14-28)31(39)25-5-10-29(34-20-25)35-30(38)24-11-15-36(16-12-24)21-23-3-1-22(19-33)2-4-23/h1-10,20,24,28H,11-18,21H2,(H,34,35,38)	DFUCFJIFUHTKNO-UHFFFAOYSA-N	328035	1-(4-cyanobenzyl)-N-(5- (4-(4-fluorophenoxy)  piperidine-1- carbonyl)pyridin-2- yl)piperidine-4- carboxamide::US10377742, Compound 173::US9663496, Compound 173	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328035&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710684	384582951							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644241	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O5/c1-39-25-11-13-28(14-12-25)41-29-16-18-36(19-17-29)32(38)23-4-15-30(34-21-23)31(37)35-24-5-9-27(10-6-24)40-26-7-2-22(20-33)3-8-26/h2-4,7-8,11-15,21,24,27,29H,5-6,9-10,16-19H2,1H3,(H,35,37)/t24-,27+	QVGHVUBOGYEDKB-FEGDYQJNSA-N	328036	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 174::US9663496, Compound 174	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328036&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710218	384582952							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644242	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(NC(=O)C2CCN(Cc3ccc(cc3)C#N)CC2)nc1	InChI=1S/C32H32FN5O3/c33-28-8-5-24(6-9-28)30(39)25-13-17-38(18-14-25)32(41)27-7-10-29(35-20-27)36-31(40)26-11-15-37(16-12-26)21-23-3-1-22(19-34)2-4-23/h1-10,20,25-26H,11-18,21H2,(H,35,36,40)	WOIPUWNMUQRRTL-UHFFFAOYSA-N	328037	1-(4-cyanobenzyl)-N-(5- (4-(4-fluorobenzoyl)  piperidine-1- carbonyl)pyridin-2- yl)piperidine-4- carboxamide::US10377742, Compound 175::US9663496, Compound 175	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328037&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710722	384582953							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644243	Fc1ccc(O[C@H]2CCN(C2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C30H29FN4O4/c31-22-4-10-25(11-5-22)39-27-15-16-35(19-27)30(37)21-3-14-28(33-18-21)29(36)34-23-6-12-26(13-7-23)38-24-8-1-20(17-32)2-9-24/h1-5,8-11,14,18,23,26-27H,6-7,12-13,15-16,19H2,(H,34,36)/t23-,26+,27-/m0/s1	RRLULESDYPQECY-RNJDCESWSA-N	328038	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-((S)-3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 176::US9663496, Compound 176	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328038&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073399	384582954							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644244	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-23-5-1-20(2-6-23)19-35-13-15-36(16-14-35)29(38)22-3-11-26(32-18-22)34-28(37)21-4-12-27(33-17-21)39-25-9-7-24(31)8-10-25/h1-12,17-18H,13-16,19H2,(H,32,34,37)	BQJTYBHKLFNTMP-UHFFFAOYSA-N	328039	N-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2-yl)- 6-(4-fluorophenoxy)  nicotinamide::US10377742, Compound 177::US9663496, Compound 177	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328039&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710821	384582955							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644245	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)25-6-11-29(34-20-25)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	HMMQLGQVAFWIOP-UHFFFAOYSA-N	328040	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 178::US9663496, Compound 178	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328040&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710494	384582956							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644246	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C31H32F4N4O3/c32-24-6-1-21(2-7-24)20-38-15-11-25(12-16-38)37-29(40)28-10-3-22(19-36-28)30(41)39-17-13-27(14-18-39)42-26-8-4-23(5-9-26)31(33,34)35/h1-10,19,25,27H,11-18,20H2,(H,37,40)	RVROKBCZVIZYLZ-UHFFFAOYSA-N	328041	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 179::US9663496, Compound 179	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328041&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710492	384582957							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644247	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C30H32F2N4O3/c31-23-4-1-21(2-5-23)20-35-15-11-25(12-16-35)34-29(37)28-10-3-22(19-33-28)30(38)36-17-13-27(14-18-36)39-26-8-6-24(32)7-9-26/h1-10,19,25,27H,11-18,20H2,(H,34,37)	YUSQDVWUKSSAEC-UHFFFAOYSA-N	328042	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 180::US9663496, Compound 180	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328042&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073378	384582958							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644248	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1	InChI=1S/C31H32F2N4O3/c32-25-6-1-21(2-7-25)20-36-15-13-27(14-16-36)35-30(39)28-10-5-24(19-34-28)31(40)37-17-11-23(12-18-37)29(38)22-3-8-26(33)9-4-22/h1-10,19,23,27H,11-18,20H2,(H,35,39)	MBOYAXNHBWUBSB-UHFFFAOYSA-N	328043	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 181::US9663496, Compound 181	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328043&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073166	384582959							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644249	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CC[C@@H](C2)Oc2ccc(F)cc2)cc1	InChI=1S/C29H30F2N4O3/c30-22-4-1-20(2-5-22)18-34-14-11-24(12-15-34)33-28(36)27-10-3-21(17-32-27)29(37)35-16-13-26(19-35)38-25-8-6-23(31)7-9-25/h1-10,17,24,26H,11-16,18-19H2,(H,33,36)/t26-/m0/s1	JZOSWLKELUSKPW-SANMLTNESA-N	328044	(S)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 182::US9663496, Compound 182	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328044&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073186	384582960							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644250	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O4/c1-39-26-7-9-27(10-8-26)40-28-14-18-36(19-15-28)31(38)23-4-11-29(33-20-23)30(37)34-25-12-16-35(17-13-25)21-22-2-5-24(32)6-3-22/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	WETBWPNUDSHYAH-UHFFFAOYSA-N	328045	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 183::US9663496, Compound 183	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328045&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710706	384582961							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644251	COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C33H37N3O6/c1-40-26-8-3-22(4-9-26)31(37)23-17-19-36(20-18-23)33(39)24-5-16-30(34-21-24)32(38)35-25-6-10-28(11-7-25)42-29-14-12-27(41-2)13-15-29/h3-5,8-9,12-16,21,23,25,28H,6-7,10-11,17-20H2,1-2H3,(H,35,38)/t25-,28+	ISJZSMNECCVWQR-XBMBGIQASA-N	328046	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-((cis)-4-(4- methoxyphenoxy)  cyclohexyl)picolinamide::US9663496, Compound 184	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328046&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710658	384582962							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644252	COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C32H34F3N3O5/c1-41-24-11-13-27(14-12-24)42-26-9-5-23(6-10-26)37-30(39)29-15-2-21(20-36-29)31(40)38-18-16-28(17-19-38)43-25-7-3-22(4-8-25)32(33,34)35/h2-4,7-8,11-15,20,23,26,28H,5-6,9-10,16-19H2,1H3,(H,37,39)/t23-,26+	QKTLBWHRMYOPPU-VJXHGUGDSA-N	328047	N-((cis)-4-(4- methoxyphenoxy)  cyclohexyl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 185::US9663496, Compound 185	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328047&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710373	384582963							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644253	COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(OC)cc2)cc1	InChI=1S/C32H37N3O6/c1-38-24-8-12-27(13-9-24)40-26-6-4-23(5-7-26)34-31(36)30-16-3-22(21-33-30)32(37)35-19-17-29(18-20-35)41-28-14-10-25(39-2)11-15-28/h3,8-16,21,23,26,29H,4-7,17-20H2,1-2H3,(H,34,36)/t23-,26+	KNSGWXFUNINQIP-VJXHGUGDSA-N	328048	N-((cis)-4-(4- methoxyphenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 186::US9663496, Compound 186	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328048&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710576	384582964							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644254	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C29H30F4N4O2/c30-24-6-1-21(2-7-24)20-35-15-17-37(18-16-35)28(38)22-3-10-27(34-19-22)36-13-11-26(12-14-36)39-25-8-4-23(5-9-25)29(31,32)33/h1-10,19,26H,11-18,20H2	NLRIVKKELMUADS-UHFFFAOYSA-N	328049	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)pyridin-3- yl)methanone::US10377742, Compound 187::US9663496, Compound 187	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328049&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073149	384582965							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644255	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C29H30FN5O2/c30-25-6-1-23(2-7-25)21-33-15-17-35(18-16-33)29(36)24-5-10-28(32-20-24)34-13-11-27(12-14-34)37-26-8-3-22(19-31)4-9-26/h1-10,20,27H,11-18,21H2	BWGZBBSRFIGRTF-UHFFFAOYSA-N	328050	4-(1-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2- yl)piperidin-4- yloxy)benzonitrile::US10377742, Compound 188::US9663496, Compound 188	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328050&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073251	384582966							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644256	COc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H33FN4O3/c1-38-27-9-4-23(5-10-27)29(36)24-12-14-34(15-13-24)28-11-6-25(20-32-28)30(37)35-18-16-33(17-19-35)21-22-2-7-26(31)8-3-22/h2-11,20,24H,12-19,21H2,1H3	CHWFYLUDMGYJQK-UHFFFAOYSA-N	328051	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4-(4- methoxybenzoyl)  piperidin-1-yl)pyridin-3- yl)methanone::US10377742, Compound 189::US9663496, Compound 189	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328051&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073269	384582967							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644257	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H31F3N4O4/c33-32(34,35)23-4-10-26(11-5-23)43-28-15-17-39(18-16-28)31(41)22-3-14-29(37-20-22)30(40)38-24-6-12-27(13-7-24)42-25-8-1-21(19-36)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,38,40)/t24-,27+	QMWAQWPUELAOOP-FEGDYQJNSA-N	328052	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 190::US9663496, Compound 190	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328052&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710521	384582968							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644258	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C32H34F3N3O5/c1-41-24-11-13-27(14-12-24)43-28-16-18-38(19-17-28)31(40)21-2-15-29(36-20-21)30(39)37-23-5-9-26(10-6-23)42-25-7-3-22(4-8-25)32(33,34)35/h2-4,7-8,11-15,20,23,26,28H,5-6,9-10,16-19H2,1H3,(H,37,39)/t23-,26+	SHXRZVBBZQBCEM-VJXHGUGDSA-N	328053	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-((cis)-4-(4- (trifluoromethyl)  phenoxy)cyclohexyl)  picolinamide::US10377742, Compound 191::US9663496, Compound 191	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328053&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710288	384582969							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644259	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C(F)(F)F	InChI=1S/C33H34F3N3O5/c1-43-26-9-2-21(3-10-26)30(40)22-16-18-39(19-17-22)32(42)23-4-15-29(37-20-23)31(41)38-25-7-13-28(14-8-25)44-27-11-5-24(6-12-27)33(34,35)36/h2-6,9-12,15,20,22,25,28H,7-8,13-14,16-19H2,1H3,(H,38,41)/t25-,28+	SWQOOGAKPQTEBM-XBMBGIQASA-N	328054	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-((cis)-4-(4- (trifluoromethyl)  phenoxy)cyclohexyl)  picolinamide::US10377742, Compound 192::US9663496, Compound 192	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328054&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710578	384582970							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644260	FC(F)(F)c1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C33H31F3N4O4/c34-33(35,36)25-6-10-27(11-7-25)44-28-12-8-26(9-13-28)39-31(42)29-14-5-24(20-38-29)32(43)40-17-15-23(16-18-40)30(41)22-3-1-21(19-37)2-4-22/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,39,42)/t26-,28+	WQIQPCWIUZZIAP-DBAYTGFXSA-N	328055	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-((cis)-4-(4- (trifluoromethyl)  phenoxy)cyclohexyl)  picolinamide::US9663496, Compound 193	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328055&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486203	384582971							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644261	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O4/c1-45-32-11-6-27(7-12-32)34(42)28-14-22-41(23-15-28)36(44)29-8-13-33(37-24-29)35(43)38-30-16-20-39(21-17-30)25-26-4-9-31(10-5-26)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	RHQBNIHWJYVFEX-UHFFFAOYSA-N	328056	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 194::US9663496, Compound 194	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328056&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710402	384582972							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644262	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O4/c1-43-30-9-11-31(12-10-30)44-32-16-22-40(23-17-32)35(42)27-6-13-33(36-24-27)34(41)37-28-14-20-38(21-15-28)25-26-4-7-29(8-5-26)39-18-2-3-19-39/h4-13,24,28,32H,2-3,14-23,25H2,1H3,(H,37,41)	LBWSKARKXNZTCX-UHFFFAOYSA-N	328057	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 195::US9663496, Compound 195	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328057&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710415	384582973							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644263	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C34H40FN5O3/c35-27-6-10-30(11-7-27)43-31-15-21-40(22-16-31)34(42)26-5-12-32(36-23-26)33(41)37-28-13-19-38(20-14-28)24-25-3-8-29(9-4-25)39-17-1-2-18-39/h3-12,23,28,31H,1-2,13-22,24H2,(H,37,41)	ZLSKBKAXFNIQNY-UHFFFAOYSA-N	328058	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 196::US9663496, Compound 196	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328058&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073145	384582974							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644264	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O3/c36-23-26-5-10-31(11-6-26)44-32-15-21-41(22-16-32)35(43)28-7-12-33(37-24-28)34(42)38-29-13-19-39(20-14-29)25-27-3-8-30(9-4-27)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)	NPOOJORPIVLQMN-UHFFFAOYSA-N	328059	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 197::US9663496, Compound 197	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328059&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710541	384582975							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644265	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(C#N)c(F)c1	InChI=1S/C33H33FN4O5/c1-42-26-8-2-21(3-9-26)31(39)22-14-16-38(17-15-22)33(41)24-5-13-30(36-20-24)32(40)37-25-6-11-27(12-7-25)43-28-10-4-23(19-35)29(34)18-28/h2-5,8-10,13,18,20,22,25,27H,6-7,11-12,14-17H2,1H3,(H,37,40)/t25-,27+	FAARIKCYZYCEPQ-LDNJAJMQSA-N	328060	N-((cis)-4-(4-cyano-3- fluorophenoxy)  cyclohexyl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 198	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328060&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710405	384582976							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644266	Fc1cc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)C(F)(F)F)ccc1C#N	InChI=1S/C33H30F4N4O4/c34-28-17-27(9-3-22(28)18-38)45-26-10-7-25(8-11-26)40-31(43)29-12-4-23(19-39-29)32(44)41-15-13-21(14-16-41)30(42)20-1-5-24(6-2-20)33(35,36)37/h1-6,9,12,17,19,21,25-26H,7-8,10-11,13-16H2,(H,40,43)/t25-,26+	SSTSEIYWEOVNLI-WMPKNSHKSA-N	328061	N-((cis)-4-(4-cyano-3- fluorophenoxy)  cyclohexyl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 199	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328061&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486204	384582977							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644267	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-11-26(12-16-36)35-30(38)29-10-5-24(20-34-29)31(39)37-17-13-28(14-18-37)40-27-8-3-22(19-33)4-9-27/h1-10,20,26,28H,11-18,21H2,(H,35,38)	FYYVQVLSHZEUEM-UHFFFAOYSA-N	328062	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 200::US9663496, Compound 200	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328062&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710558	384582978							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644268	NC(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN6O3/c32-26-8-3-23(4-9-26)21-37-15-17-38(18-16-37)31(41)25-7-10-28(34-19-25)30(40)35-27-11-13-36(14-12-27)20-22-1-5-24(6-2-22)29(33)39/h1-10,19,27H,11-18,20-21H2,(H2,33,39)(H,35,40)	KAGDFRKVOFDGOY-UHFFFAOYSA-N	328063	N-(1-(4- carbamoylbenzyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 201::US9663496, Compound 201	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328063&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073393	384582979							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644269	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(C)(=O)=O)cc1	InChI=1S/C32H38N4O6S/c1-41-26-6-3-23(4-7-26)22-35-17-13-25(14-18-35)34-31(37)30-12-5-24(21-33-30)32(38)36-19-15-28(16-20-36)42-27-8-10-29(11-9-27)43(2,39)40/h3-12,21,25,28H,13-20,22H2,1-2H3,(H,34,37)	MQWPEEINQVFKJZ-UHFFFAOYSA-N	328064	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 202	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328064&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710508	384582980							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644270	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O5S/c1-43(40,41)28-5-3-26(4-6-28)42-27-10-14-37(15-11-27)31(39)22-2-7-29(34-19-22)30(38)35-25-8-12-36(13-9-25)20-21-16-23(32)18-24(33)17-21/h2-7,16-19,25,27H,8-15,20H2,1H3,(H,35,38)	ZKEBDQJMFGPWQM-UHFFFAOYSA-N	328065	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 203	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328065&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710697	384582981							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644271	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C30H26FN5O5/c1-40-23-7-2-19(3-8-23)28(37)20-12-14-36(15-13-20)30(39)26-18-32-25(17-33-26)29(38)35-22-6-11-27(34-16-22)41-24-9-4-21(31)5-10-24/h2-11,16-18,20H,12-15H2,1H3,(H,35,38)	IOMURNIMMPXUFN-UHFFFAOYSA-N	328066	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 204::US9663496, Compound 204	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328066&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710398	384582982							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644272	Fc1ccc(Oc2ccc(NC(=O)c3cnc(cn3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C(F)(F)F)cn2)cc1	InChI=1S/C29H23F4N5O4/c30-19-3-8-22(9-4-19)42-26-10-5-20(15-36-26)37-27(39)24-16-35-25(17-34-24)28(40)38-13-11-23(12-14-38)41-21-6-1-18(2-7-21)29(31,32)33/h1-10,15-17,23H,11-14H2,(H,37,39)	FIRJMSDQQVUXBK-UHFFFAOYSA-N	328067	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 205::US9663496, Compound 205	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328067&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710284	384582983							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644273	Fc1ccc(Oc2ccc(NC(=O)c3cnc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C29H22F3N5O4/c30-18-1-5-21(6-2-18)41-26-8-4-20(14-35-26)36-28(39)24-15-34-25(16-33-24)29(40)37-11-9-17(10-12-37)27(38)22-7-3-19(31)13-23(22)32/h1-8,13-17H,9-12H2,(H,36,39)	NFXJMTPKKPWDFD-UHFFFAOYSA-N	328068	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)pyrazine-2- carboxamide::US10377742, Compound 206::US9663496, Compound 206	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328068&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073205	384582984							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644274	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H26FN5O6S/c1-42(38,39)24-9-7-21(8-10-24)40-23-12-14-35(15-13-23)29(37)26-18-31-25(17-32-26)28(36)34-20-4-11-27(33-16-20)41-22-5-2-19(30)3-6-22/h2-11,16-18,23H,12-15H2,1H3,(H,34,36)	QCXQVZWBOYNJPB-UHFFFAOYSA-N	328069	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US9663496, Compound 207	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328069&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710421	384582985							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644275	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O5S/c1-46(43,44)32-11-9-30(10-12-32)45-31-16-22-40(23-17-31)35(42)27-6-13-33(36-24-27)34(41)37-28-14-20-38(21-15-28)25-26-4-7-29(8-5-26)39-18-2-3-19-39/h4-13,24,28,31H,2-3,14-23,25H2,1H3,(H,37,41)	NTWQKRFJFGQARC-UHFFFAOYSA-N	328070	5-(4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US9663496, Compound 208	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328070&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710511	384582986							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644276	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CC(C1)Oc1ccc(cc1)C#N	InChI=1S/C30H28N6O3/c31-15-21-1-3-23(4-2-21)18-35-13-11-25(12-14-35)34-29(37)28-10-7-24(17-33-28)30(38)36-19-27(20-36)39-26-8-5-22(16-32)6-9-26/h1-10,17,25,27H,11-14,18-20H2,(H,34,37)	WKWOWUPNJQOYOV-UHFFFAOYSA-N	328071	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)picolinamide::US10377742, Compound 209::US9663496, Compound 209	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328071&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710784	384582987							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644277	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CC(C3)Oc3ccc(cc3)C#N)cn2)cc1	InChI=1S/C28H20FN5O4/c29-20-4-9-23(10-5-20)38-26-12-6-21(15-32-26)33-27(35)25-11-3-19(14-31-25)28(36)34-16-24(17-34)37-22-7-1-18(13-30)2-8-22/h1-12,14-15,24H,16-17H2,(H,33,35)	JGBMPZMXPFSPDG-UHFFFAOYSA-N	328072	5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 210::US9663496, Compound 210	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328072&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651337	384582988							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644278	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-27-8-6-24(7-9-27)30(39)25-10-16-38(17-11-25)32(41)29-20-34-28(19-35-29)31(40)36-26-12-14-37(15-13-26)21-23-4-2-22(18-33)3-5-23/h2-9,19-20,25-26H,10-17,21H2,1H3,(H,36,40)	NPKHHIRWHYYJGW-UHFFFAOYSA-N	328073	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 211::US9663496, Compound 211	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328073&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651338	384582989							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644279	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H31F3N6O3/c32-31(33,34)23-5-7-25(8-6-23)43-26-11-15-40(16-12-26)30(42)28-19-36-27(18-37-28)29(41)38-24-9-13-39(14-10-24)20-22-3-1-21(17-35)2-4-22/h1-8,18-19,24,26H,9-16,20H2,(H,38,41)	AFFMBBJVFRZUEW-UHFFFAOYSA-N	328074	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 212::US9663496, Compound 212	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328074&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710199	384582990							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644280	CS(=O)(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O5S/c1-44(42,43)26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)23-4-9-29(35-19-23)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	FXHBRSQJDSUPGH-UHFFFAOYSA-N	328075	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)benzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 213::US9663496, Compound 213	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328075&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710353	384582991							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644281	CS(=O)(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O5S/c1-43(40,41)29-9-4-24(5-10-29)22-36-16-12-26(13-17-36)35-31(38)25-6-11-30(34-21-25)32(39)37-18-14-28(15-19-37)42-27-7-2-23(20-33)3-8-27/h2-11,21,26,28H,12-19,22H2,1H3,(H,35,38)	RQSXOONFDVZBCK-UHFFFAOYSA-N	328076	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)benzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 214::US9663496, Compound 214	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328076&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710469	384582992							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644282	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)S(C)(=O)=O)CC1	InChI=1S/C33H38N4O6S/c1-43-28-8-5-24(6-9-28)31(38)25-13-19-37(20-14-25)33(40)30-12-7-26(21-34-30)32(39)35-27-15-17-36(18-16-27)22-23-3-10-29(11-4-23)44(2,41)42/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	PNWSOXVXBMGWGH-UHFFFAOYSA-N	328077	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)benzyl)  piperidin-4- yl)nicotinamide::US9663496, Compound 215	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328077&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710777	384582993							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644283	CS(=O)(=O)Nc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H35F2N5O5S/c1-45(43,44)37-26-6-2-21(3-7-26)20-38-14-12-25(13-15-38)36-31(41)23-4-9-29(35-19-23)32(42)39-16-10-22(11-17-39)30(40)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25,37H,10-17,20H2,1H3,(H,36,41)	PLFKPSQUHVQKGD-UHFFFAOYSA-N	328078	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonamido)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 216::US9663496, Compound 216	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328078&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710643	384582994							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644284	CS(=O)(=O)Nc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H36N6O5S/c1-44(41,42)36-27-7-2-24(3-8-27)22-37-16-12-26(13-17-37)35-31(39)25-6-11-30(34-21-25)32(40)38-18-14-29(15-19-38)43-28-9-4-23(20-33)5-10-28/h2-11,21,26,29,36H,12-19,22H2,1H3,(H,35,39)	KHXARCSTRQBUHC-UHFFFAOYSA-N	328079	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonamido)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 217::US9663496, Compound 217	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328079&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651339	384582995							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644285	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O5S/c1-43(40,41)27-8-6-25(7-9-27)42-26-12-16-37(17-13-26)31(39)29-20-33-28(19-34-29)30(38)35-24-10-14-36(15-11-24)21-23-4-2-22(18-32)3-5-23/h2-9,19-20,24,26H,10-17,21H2,1H3,(H,35,38)	XEJSNQXXZSURCC-UHFFFAOYSA-N	328080	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US9663496, Compound 218	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328080&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651340	384582996							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644286	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1cnc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C35H39N7O3/c36-21-25-3-5-26(6-4-25)24-40-17-13-29(14-18-40)39-34(44)31-22-38-32(23-37-31)35(45)42-19-11-28(12-20-42)33(43)27-7-9-30(10-8-27)41-15-1-2-16-41/h3-10,22-23,28-29H,1-2,11-20,24H2,(H,39,44)	HVWHBZWYBCRQOP-UHFFFAOYSA-N	328081	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 219::US9663496, Compound 219	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328081&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710464	384582997							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644287	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C36H42N8O3/c1-41-18-20-43(21-19-41)31-8-6-28(7-9-31)34(45)29-10-16-44(17-11-29)36(47)33-24-38-32(23-39-33)35(46)40-30-12-14-42(15-13-30)25-27-4-2-26(22-37)3-5-27/h2-9,23-24,29-30H,10-21,25H2,1H3,(H,40,46)	YFJQTHWORCUTFF-UHFFFAOYSA-N	328082	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 220::US9663496, Compound 220	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328082&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710371	384582998							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644288	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O5S/c1-44(42,43)29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)30-11-8-27(21-35-30)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	VCWGXNOMDMWBQR-UHFFFAOYSA-N	328083	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 221	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328083&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710392	384582999							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644289	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O5S/c1-43(41,42)28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)29-11-6-25(20-34-29)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	CJXMSWGFOSLNON-UHFFFAOYSA-N	328084	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 222	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328084&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710713	384583000							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644290	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)S(C)(=O)=O)cc1	InChI=1S/C33H38N4O6S/c1-43-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)26-7-12-30(34-21-26)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(11-6-24)44(2,41)42/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	LQCGDAYXUKPYRS-UHFFFAOYSA-N	328085	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 223	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328085&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710292	384583001							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644291	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O6S/c1-43(40,41)26-10-2-20(3-11-26)29(37)21-14-16-36(17-15-21)31(39)27-12-4-22(18-33-27)30(38)35-24-7-13-28(34-19-24)42-25-8-5-23(32)6-9-25/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	OBDUAWCDQPGNEJ-UHFFFAOYSA-N	328086	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 224	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328086&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710302	384583002							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644292	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O5S/c1-43(41,42)28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)25-6-11-29(34-20-25)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	VWXDXCSIQDTZCR-UHFFFAOYSA-N	328087	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 225	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328087&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710552	384583003							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644293	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O5S/c1-42(39,40)28-9-7-26(8-10-28)41-27-14-18-36(19-15-27)31(38)23-4-11-29(33-20-23)30(37)34-25-12-16-35(17-13-25)21-22-2-5-24(32)6-3-22/h2-11,20,25,27H,12-19,21H2,1H3,(H,34,37)	OSDWJNCUKUCBNN-UHFFFAOYSA-N	328088	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 226	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328088&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710372	384583004							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644294	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O5S/c1-43(40,41)29-9-7-27(8-10-29)42-28-14-18-37(19-15-28)32(39)25-6-11-30(34-21-25)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,35,38)	RGMLWMKCJWCRMT-UHFFFAOYSA-N	328089	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 227	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328089&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710781	384583005							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644295	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O5S/c1-44(42,43)29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	QMTGLMZJPRBLIN-UHFFFAOYSA-N	328090	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 228	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328090&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710839	384583006							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644296	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O5S/c1-47(45,46)32-11-6-27(7-12-32)34(42)28-14-22-41(23-15-28)36(44)33-13-8-29(24-37-33)35(43)38-30-16-20-39(21-17-30)25-26-4-9-31(10-5-26)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	HOQCTJJZQCSPJZ-UHFFFAOYSA-N	328091	6-(4-(4-(methylsulfonyl)  benzoyl)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US9663496, Compound 229	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328091&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710262	384583007							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644297	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O5S/c1-46(43,44)32-11-9-30(10-12-32)45-31-16-22-40(23-17-31)35(42)33-13-6-27(24-36-33)34(41)37-28-14-20-38(21-15-28)25-26-4-7-29(8-5-26)39-18-2-3-19-39/h4-13,24,28,31H,2-3,14-23,25H2,1H3,(H,37,41)	CSBDVKDQMZPDIN-UHFFFAOYSA-N	328092	6-(4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US9663496, Compound 230	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328092&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710239	384583008							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644298	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C30H27FN4O6S/c1-42(38,39)26-10-8-23(9-11-26)40-25-14-16-35(17-15-25)30(37)20-2-12-27(32-18-20)29(36)34-22-5-13-28(33-19-22)41-24-6-3-21(31)4-7-24/h2-13,18-19,25H,14-17H2,1H3,(H,34,36)	XWWJYYIIEPOVPR-UHFFFAOYSA-N	328093	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 231	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328093&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710252	384583009							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644299	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O6S/c1-43(40,41)26-10-2-20(3-11-26)29(37)21-14-16-36(17-15-21)31(39)22-4-12-27(33-18-22)30(38)35-24-7-13-28(34-19-24)42-25-8-5-23(32)6-9-25/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	SYDMZSWJNJRJCD-UHFFFAOYSA-N	328094	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 232	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328094&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651341	384583010							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644300	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O5S/c1-47(45,46)32-11-6-27(7-12-32)34(42)28-14-22-41(23-15-28)36(44)29-8-13-33(37-24-29)35(43)38-30-16-20-39(21-17-30)25-26-4-9-31(10-5-26)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	CAOBURXJSVJLDC-UHFFFAOYSA-N	328095	5-(4-(4-(methylsulfonyl)  benzoyl)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US9663496, Compound 233	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328095&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651674	384583011							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644301	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)S(C)(=O)=O)cc1	InChI=1S/C33H38N4O6S/c1-43-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)30-12-7-26(21-34-30)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(11-6-24)44(2,41)42/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	SBQZJWMIZZHEME-UHFFFAOYSA-N	328096	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-5-(4-(4- (methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 234	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328096&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710522	384583012							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644302	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C30H27FN4O6S/c1-42(38,39)26-10-8-23(9-11-26)40-25-14-16-35(17-15-25)30(37)27-12-2-20(18-32-27)29(36)34-22-5-13-28(33-19-22)41-24-6-3-21(31)4-7-24/h2-13,18-19,25H,14-17H2,1H3,(H,34,36)	CNBBJUYUALHJAB-UHFFFAOYSA-N	328097	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 235	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328097&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710540	384583013							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644303	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O5S/c1-43(40,41)28-5-3-26(4-6-28)42-27-10-14-37(15-11-27)31(39)29-7-2-22(19-34-29)30(38)35-25-8-12-36(13-9-25)20-21-16-23(32)18-24(33)17-21/h2-7,16-19,25,27H,8-15,20H2,1H3,(H,35,38)	SCLZKSLYQIVDQL-UHFFFAOYSA-N	328098	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 236	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328098&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710570	384583014							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644304	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(C)(=O)=O)cc1	InChI=1S/C32H38N4O6S/c1-41-26-6-3-23(4-7-26)22-35-17-13-25(14-18-35)34-31(37)24-5-12-30(33-21-24)32(38)36-19-15-28(16-20-36)42-27-8-10-29(11-9-27)43(2,39)40/h3-12,21,25,28H,13-20,22H2,1-2H3,(H,34,37)	DCJUOYBOVODPDJ-UHFFFAOYSA-N	328099	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 237	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328099&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710782	384583015							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644305	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(C)(=O)=O)c1	InChI=1S/C32H38N4O6S/c1-41-28-5-3-4-23(20-28)22-35-16-12-25(13-17-35)34-31(37)24-6-11-30(33-21-24)32(38)36-18-14-27(15-19-36)42-26-7-9-29(10-8-26)43(2,39)40/h3-11,20-21,25,27H,12-19,22H2,1-2H3,(H,34,37)	FUUNBRUAMFYPRS-UHFFFAOYSA-N	328100	N-(1-(3-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 238	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328100&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710470	384583016							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644306	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C32H35F3N4O6S/c1-46(42,43)28-8-6-25(7-9-28)44-26-13-17-39(18-14-26)31(41)29-10-5-23(20-36-29)30(40)37-24-11-15-38(16-12-24)21-22-3-2-4-27(19-22)45-32(33,34)35/h2-10,19-20,24,26H,11-18,21H2,1H3,(H,37,40)	HLFMHUFIGPKBDK-UHFFFAOYSA-N	328101	6-(4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US9663496, Compound 239	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328101&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710282	384583017							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644307	[N-]=[N+]=Nc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32N8O3/c33-19-22-1-3-23(4-2-22)21-39-15-13-27(14-16-39)36-31(42)26-7-10-29(35-20-26)32(43)40-17-11-25(12-18-40)30(41)24-5-8-28(9-6-24)37-38-34/h1-10,20,25,27H,11-18,21H2,(H,36,42)	PUIJFXMIHQEIKP-UHFFFAOYSA-N	328102	6-(4-(4- azidobenzoyl)piperidine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 240::US9663496, Compound 240	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328102&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			89724914	384583018							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644308	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(C)(=O)=O)c1	InChI=1S/C32H38N4O6S/c1-41-28-5-3-4-23(20-28)22-35-16-12-25(13-17-35)34-31(37)30-11-6-24(21-33-30)32(38)36-18-14-27(15-19-36)42-26-7-9-29(10-8-26)43(2,39)40/h3-11,20-21,25,27H,12-19,22H2,1-2H3,(H,34,37)	HIIOLRICGCUOPM-UHFFFAOYSA-N	328103	N-(1-(3-methoxybenzyl)  piperidin-4-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 241	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328103&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710254	384583019							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644309	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C32H35F3N4O6S/c1-46(42,43)28-8-6-25(7-9-28)44-26-13-17-39(18-14-26)31(41)23-5-10-29(36-20-23)30(40)37-24-11-15-38(16-12-24)21-22-3-2-4-27(19-22)45-32(33,34)35/h2-10,19-20,24,26H,11-18,21H2,1H3,(H,37,40)	GAPLEWRIBFUXRK-UHFFFAOYSA-N	328104	5-(4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)picolinamide::US9663496, Compound 242	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328104&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710315	384583020							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644310	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C37H43N7O3/c1-41-20-22-43(23-21-41)33-9-6-29(7-10-33)35(45)30-12-18-44(19-13-30)37(47)34-11-8-31(25-39-34)36(46)40-32-14-16-42(17-15-32)26-28-4-2-27(24-38)3-5-28/h2-11,25,30,32H,12-23,26H2,1H3,(H,40,46)	DNOOJFBSTXDBIH-UHFFFAOYSA-N	328105	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 243::US9663496, Compound 243	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328105&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710526	384583021							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644311	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C37H43F3N6O4/c1-43-20-22-45(23-21-43)31-7-4-27(5-8-31)34(47)28-12-18-46(19-13-28)36(49)33-11-6-29(24-41-33)35(48)42-30-14-16-44(17-15-30)25-26-2-9-32(10-3-26)50-37(38,39)40/h2-11,24,28,30H,12-23,25H2,1H3,(H,42,48)	BSKIKGJMGXCCRR-UHFFFAOYSA-N	328106	6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 244::US9663496, Compound 244	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328106&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710318	384583022							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644312	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C35H35FN6O4/c1-40-18-20-41(21-19-40)29-8-2-24(3-9-29)33(43)25-14-16-42(17-15-25)35(45)31-12-4-26(22-37-31)34(44)39-28-7-13-32(38-23-28)46-30-10-5-27(36)6-11-30/h2-13,22-23,25H,14-21H2,1H3,(H,39,44)	CSSYEVQJDFHNJP-UHFFFAOYSA-N	328107	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 245::US9663496, Compound 245	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328107&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710727	384583023							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644313	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C34H37N5O5S/c35-21-24-1-3-25(4-2-24)23-38-17-13-27(14-18-38)37-33(40)26-5-12-32(36-22-26)34(41)39-19-15-29(16-20-39)44-28-6-8-30(9-7-28)45(42,43)31-10-11-31/h1-9,12,22,27,29,31H,10-11,13-20,23H2,(H,37,40)	CINVMDLCMBUCQO-UHFFFAOYSA-N	328108	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 246::US9663496, Compound 246	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328108&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710410	384583024							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644314	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(=O)(=O)C3CC3)cn2)cc1	InChI=1S/C32H29FN4O6S/c33-22-2-5-25(6-3-22)43-30-14-4-23(20-35-30)36-31(38)21-1-13-29(34-19-21)32(39)37-17-15-26(16-18-37)42-24-7-9-27(10-8-24)44(40,41)28-11-12-28/h1-10,13-14,19-20,26,28H,11-12,15-18H2,(H,36,38)	ZZWJDICOSBHOKT-UHFFFAOYSA-N	328109	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 247::US9663496, Compound 247	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328109&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710789	384583025							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644315	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C37H45N5O5S/c43-36(39-29-15-21-40(22-16-29)26-27-3-6-30(7-4-27)41-19-1-2-20-41)28-5-14-35(38-25-28)37(44)42-23-17-32(18-24-42)47-31-8-10-33(11-9-31)48(45,46)34-12-13-34/h3-11,14,25,29,32,34H,1-2,12-13,15-24,26H2,(H,39,43)	WTXNEQJNAQMKMM-UHFFFAOYSA-N	328110	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 248::US9663496, Compound 248	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328110&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710451	384583026							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644316	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(=O)(=O)C2CC2)cc1	InChI=1S/C34H37F3N4O6S/c35-34(36,37)47-28-4-1-23(2-5-28)22-40-17-13-25(14-18-40)39-32(42)24-3-12-31(38-21-24)33(43)41-19-15-27(16-20-41)46-26-6-8-29(9-7-26)48(44,45)30-10-11-30/h1-9,12,21,25,27,30H,10-11,13-20,22H2,(H,39,42)	LOCVLBUUUHGTAV-UHFFFAOYSA-N	328111	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 249::US9663496, Compound 249	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328111&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710535	384583027							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644317	CS(=O)(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H34N6O4S/c1-42(40,41)28-9-7-27(8-10-28)36-16-18-37(19-17-36)31(39)25-6-11-29(33-21-25)30(38)34-26-12-14-35(15-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,26H,12-19,22H2,1H3,(H,34,38)	BTSNKVPIXNQCGQ-UHFFFAOYSA-N	328112	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylsulfonyl)phenyl) piperazine-1- carbonyl)picolinamide::US9663496, Compound 250	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328112&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710587	384583028							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644318	CC(C)S(=O)(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H38N6O4S/c1-24(2)44(42,43)30-10-8-29(9-11-30)38-17-19-39(20-18-38)33(41)27-7-12-31(35-22-27)32(40)36-28-13-15-37(16-14-28)23-26-5-3-25(21-34)4-6-26/h3-12,22,24,28H,13-20,23H2,1-2H3,(H,36,40)	SLABLTVAPPOUGP-UHFFFAOYSA-N	328113	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (isopropylsulfonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US9663496, Compound 251	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328113&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710692	384583029							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644319	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O5S/c1-45(43,44)27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)26-8-11-30(36-19-26)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m1/s1	IKZUOIYXCIBCLH-FQLXRVMXSA-N	328114	N-((trans)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4-(methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 252	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328114&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710548	384583030							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644320	CS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@H]1F	InChI=1S/C33H34F4N4O6S/c1-48(45,46)26-9-4-22(5-10-26)30(42)23-12-16-41(17-13-23)32(44)24-6-11-29(38-18-24)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-25(8-3-21)47-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28-/m1/s1	MWVAIOSVWVODAN-VSGBNLITSA-N	328115	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)  benzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)  benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 253	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328115&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710538	384583031							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644321	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(cc3)C#N)C[C@H]2F)cc1	InChI=1S/C32H34FN5O5S/c1-44(41,42)27-9-7-25(8-10-27)43-26-12-16-38(17-13-26)32(40)24-6-11-30(35-19-24)31(39)36-29-14-15-37(21-28(29)33)20-23-4-2-22(18-34)3-5-23/h2-11,19,26,28-29H,12-17,20-21H2,1H3,(H,36,39)/t28-,29-/m1/s1	GYXYLTXHDOYGIT-FQLXRVMXSA-N	328116	N-((trans)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 254	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328116&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710609	384583032							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644322	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)cc1	InChI=1S/C32H34F4N4O6S/c1-47(43,44)26-9-7-23(8-10-26)45-24-12-16-40(17-13-24)31(42)22-4-11-29(37-18-22)30(41)38-28-14-15-39(20-27(28)33)19-21-2-5-25(6-3-21)46-32(34,35)36/h2-11,18,24,27-28H,12-17,19-20H2,1H3,(H,38,41)/t27-,28-/m1/s1	QYKFEEHGZRXLOV-VSGBNLITSA-N	328117	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)  benzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 255	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328117&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710514	384583033							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644323	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C33H36N6O4S/c34-21-24-1-3-25(4-2-24)23-37-15-13-27(14-16-37)36-32(40)31-12-5-26(22-35-31)33(41)39-19-17-38(18-20-39)28-6-8-29(9-7-28)44(42,43)30-10-11-30/h1-9,12,22,27,30H,10-11,13-20,23H2,(H,36,40)	CWUZNYCHXNYQDR-UHFFFAOYSA-N	328118	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (cyclopropylsulfonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 256::US9663496, Compound 256	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328118&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710418	384583034							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644324	FC(F)(F)S(=O)(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31F3N6O4S/c32-31(33,34)45(43,44)27-8-6-26(7-9-27)39-15-17-40(18-16-39)30(42)24-5-10-28(36-20-24)29(41)37-25-11-13-38(14-12-25)21-23-3-1-22(19-35)2-4-23/h1-10,20,25H,11-18,21H2,(H,37,41)	CIYOQUUILYLVDA-UHFFFAOYSA-N	328119	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylsulfonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 257::US9663496, Compound 257	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328119&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710255	384583035							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644325	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)C(=O)C1CC1	InChI=1S/C34H36N6O3/c35-21-24-1-3-25(4-2-24)23-38-15-13-29(14-16-38)37-33(42)31-12-9-28(22-36-31)34(43)40-19-17-39(18-20-40)30-10-7-27(8-11-30)32(41)26-5-6-26/h1-4,7-12,22,26,29H,5-6,13-20,23H2,(H,37,42)	SRJYEJPJELERDT-UHFFFAOYSA-N	328120	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (cyclopropanecarbonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 258::US9663496, Compound 258	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328120&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710311	384583036							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644326	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(C)(=O)=O)cn2)cc1	InChI=1S/C32H30N4O7S/c1-21(37)22-3-7-26(8-4-22)43-30-14-6-24(20-34-30)35-31(38)29-13-5-23(19-33-29)32(39)36-17-15-27(16-18-36)42-25-9-11-28(12-10-25)44(2,40)41/h3-14,19-20,27H,15-18H2,1-2H3,(H,35,38)	ZSVNPRVXUGWBPV-UHFFFAOYSA-N	328121	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 259	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328121&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710258	384583037							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644327	CCS(=O)(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C34H37N5O5S/c1-2-45(43,44)30-10-7-26(8-11-30)32(40)27-13-19-39(20-14-27)34(42)28-9-12-31(36-22-28)33(41)37-29-15-17-38(18-16-29)23-25-5-3-24(21-35)4-6-25/h3-12,22,27,29H,2,13-20,23H2,1H3,(H,37,41)	MAJCQTISSHKZIM-UHFFFAOYSA-N	328122	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (ethylsulfonyl)benzoyl)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 260	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328122&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710503	384583038							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644328	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(nc2)S(=O)(=O)c2ccc(F)cc2)cc1	InChI=1S/C30H27FN4O7S2/c1-43(38,39)25-10-6-23(7-11-25)42-24-14-16-35(17-15-24)30(37)20-2-12-27(32-18-20)29(36)34-22-5-13-28(33-19-22)44(40,41)26-8-3-21(31)4-9-26/h2-13,18-19,24H,14-17H2,1H3,(H,34,36)	WHNMAWHTJAHYFA-UHFFFAOYSA-N	328123	N-(6-(4- fluorophenylsulfonyl)  pyridin-3-yl)-5-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US9663496, Compound 261	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328123&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710501	384583039							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644329	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32FN5O4S/c32-25-6-8-27(9-7-25)42(40,41)28-13-17-37(18-14-28)31(39)24-5-10-29(34-20-24)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-33)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,35,38)	WPGURWCGKIGDPP-UHFFFAOYSA-N	328124	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 262::US9663496, Compound 262	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328124&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710286	384583040							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644330	FC(F)(F)C(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F3N6O3/c33-32(34,35)29(42)24-5-8-27(9-6-24)40-15-17-41(18-16-40)31(44)25-7-10-28(37-20-25)30(43)38-26-11-13-39(14-12-26)21-23-3-1-22(19-36)2-4-23/h1-10,20,26H,11-18,21H2,(H,38,43)	RGJWOFQNRMIXJW-UHFFFAOYSA-N	328125	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(2,2,2- trifluoroacetyl)phenyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 263::US9663496, Compound 263	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328125&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710688	384583041							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644331	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H37N5O2/c37-30(33-27-13-17-35(18-14-27)22-24-7-3-1-4-8-24)26-11-12-29(32-21-26)31(38)34-28-15-19-36(20-16-28)23-25-9-5-2-6-10-25/h1-12,21,27-28H,13-20,22-23H2,(H,33,37)(H,34,38)	GFDOYTAWIKLKSA-UHFFFAOYSA-N	328126	N2,N5-bis(1- benzylpiperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 264::US9663496, Compound 264	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328126&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710860	384583042							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644332	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCCC(C1)Oc1ccc(cc1)C#N	InChI=1S/C31H32N6O2/c32-18-23-3-5-25(6-4-23)21-36-16-13-26(14-17-36)35-31(38)30-12-9-27(20-34-30)37-15-1-2-29(22-37)39-28-10-7-24(19-33)8-11-28/h3-12,20,26,29H,1-2,13-17,21-22H2,(H,35,38)	PYKNAWSLPPFUNW-UHFFFAOYSA-N	328127	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)piperidin- 1-yl)picolinamide::US10377742, Compound 265::US9663496, Compound 265	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328127&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710439	384583043							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644333	Clc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32ClN5O2/c32-26-7-5-24(6-8-26)30(38)25-11-17-37(18-12-25)28-9-10-29(34-20-28)31(39)35-27-13-15-36(16-14-27)21-23-3-1-22(19-33)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,35,39)	JVERBNBWKSQTRY-UHFFFAOYSA-N	328128	5-(4-(4- chlorobenzoyl)piperidin- 1-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 266::US9663496, Compound 266	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328128&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710328	384583044							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644334	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(NC2CCN(CC2)c2ccc(cc2)C#N)cn1	InChI=1S/C31H33N7O/c32-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-28(21-34-30)35-26-13-17-38(18-14-26)29-8-5-24(20-33)6-9-29/h1-10,21,26-27,35H,11-18,22H2,(H,36,39)	SXLNCLDXSZOPBZ-UHFFFAOYSA-N	328129	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- cyanophenyl)piperidin- 4-ylamino)picolinamide::US10377742, Compound 267::US9663496, Compound 267	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328129&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710270	384583045							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644335	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccncc1	InChI=1S/C30H32N6O3/c31-19-22-1-3-23(4-2-22)21-35-15-9-25(10-16-35)34-29(37)28-6-5-24(20-33-28)30(38)36-17-11-27(12-18-36)39-26-7-13-32-14-8-26/h1-8,13-14,20,25,27H,9-12,15-18,21H2,(H,34,37)	AHTSNSKNLLGNAL-UHFFFAOYSA-N	328130	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2-(4- fluorophenyl)propan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 269::US9663496, Compound 268::US9663496, Compound 269	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328130&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710848	384583046							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644336	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccncc1	InChI=1S/C30H32N6O3/c31-19-22-1-3-23(4-2-22)21-35-15-9-25(10-16-35)34-29(37)28-6-5-24(20-33-28)30(38)36-17-11-27(12-18-36)39-26-7-13-32-14-8-26/h1-8,13-14,20,25,27H,9-12,15-18,21H2,(H,34,37)	AHTSNSKNLLGNAL-UHFFFAOYSA-N	328130	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2-(4- fluorophenyl)propan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 269::US9663496, Compound 268::US9663496, Compound 269	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328130&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710848	384583046							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644337	Fc1ccc(OC2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-24-6-8-26(9-7-24)39-27-13-16-36(20-27)30(38)23-5-10-28(33-18-23)29(37)34-25-11-14-35(15-12-25)19-22-3-1-21(17-32)2-4-22/h1-10,18,25,27H,11-16,19-20H2,(H,34,37)	RLJZRJSNAZYVPY-UHFFFAOYSA-N	328132	(S)-N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 270::US9663496, Compound 270	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328132&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710414	384583047							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644338	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)24-5-8-29(36-19-24)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	XRDMDDSSWUSOAX-UHFFFAOYSA-N	328133	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 271::US9663496, Compound 271	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328133&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710298	384583048							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644339	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C30H24F2N4O4/c31-22-4-1-19(2-5-22)28(37)20-13-15-36(16-14-20)30(39)21-3-11-26(33-17-21)29(38)35-24-8-12-27(34-18-24)40-25-9-6-23(32)7-10-25/h1-12,17-18,20H,13-16H2,(H,35,38)	JLWLTWZTDHMFKR-UHFFFAOYSA-N	328134	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 272::US9663496, Compound 272	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328134&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710533	384583049							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644340	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H24F2N4O4/c30-20-2-7-23(8-3-20)38-25-13-15-35(16-14-25)29(37)19-1-11-26(32-17-19)28(36)34-22-6-12-27(33-18-22)39-24-9-4-21(31)5-10-24/h1-12,17-18,25H,13-16H2,(H,34,36)	CIXKEBBNLUBQNZ-UHFFFAOYSA-N	328135	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 273::US9663496, Compound 273	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328135&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710300	384583050							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644341	COc1ccc(OC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O4/c1-40-27-9-11-28(12-10-27)41-29-3-2-16-37(22-29)32(39)25-8-13-30(34-20-25)31(38)35-26-14-17-36(18-15-26)21-24-6-4-23(19-33)5-7-24/h4-13,20,26,29H,2-3,14-18,21-22H2,1H3,(H,35,38)	KFXYGIMFSTTWQR-UHFFFAOYSA-N	328136	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 274::US9663496, Compound 274	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328136&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710710	384583051							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644342	COc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H36N6O2/c1-39-29-9-7-28(8-10-29)37-18-14-25(15-19-37)34-27-6-11-30(33-21-27)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,25-26,34H,12-19,22H2,1H3,(H,35,38)	KXVNZBABMIWAFP-UHFFFAOYSA-N	328137	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- methoxyphenyl)  piperidin-4- ylamino)picolinamide::US10377742, Compound 275::US9663496, Compound 275	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328137&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710448	384583052							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644343	Fc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H33FN6O/c31-24-5-8-28(9-6-24)37-17-13-25(14-18-37)34-27-7-10-29(33-20-27)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,25-26,34H,11-18,21H2,(H,35,38)	WDIUOLAJMWXWDH-UHFFFAOYSA-N	328138	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- fluorophenyl)piperidin- 4-ylamino)picolinamide::US10377742, Compound 276::US9663496, Compound 276	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328138&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710751	384583053							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644344	COc1cccc(OC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C32H35N5O4/c1-40-27-4-2-5-28(18-27)41-29-6-3-15-37(22-29)32(39)25-11-12-30(34-20-25)31(38)35-26-13-16-36(17-14-26)21-24-9-7-23(19-33)8-10-24/h2,4-5,7-12,18,20,26,29H,3,6,13-17,21-22H2,1H3,(H,35,38)	RSHRVHMHGAFLSZ-UHFFFAOYSA-N	328139	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(3- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 277::US9663496, Compound 277	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328139&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710461	384583054							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644345	Fc1ccc(O[C@@H]2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-24-6-8-26(9-7-24)39-27-13-16-36(20-27)30(38)23-5-10-28(33-18-23)29(37)34-25-11-14-35(15-12-25)19-22-3-1-21(17-32)2-4-22/h1-10,18,25,27H,11-16,19-20H2,(H,34,37)/t27-/m1/s1	RLJZRJSNAZYVPY-HHHXNRCGSA-N	328140	(R)-N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 278::US9663496, Compound 278	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328140&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652034	384583055							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644346	F[C@H]1CN(CC[C@@H]1Oc1ccc(cc1)C#N)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31FN6O3/c33-28-21-39(16-13-30(28)42-27-8-5-23(18-35)6-9-27)32(41)25-7-10-29(36-19-25)31(40)37-26-11-14-38(15-12-26)20-24-3-1-22(17-34)2-4-24/h1-10,19,26,28,30H,11-16,20-21H2,(H,37,40)/t28-,30-/m0/s1	ISSLZKSSYLRMSG-JDXGNMNLSA-N	328141	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-((trans)-4-(4- cyanophenoxy)-3- fluoropiperidine-1- carbonyl)picolinamide::US10377742, Compound 279::US9663496, Compound 279	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328141&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710441	384583056							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644347	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1C2CCC1CC(C2)Oc1ccc(cc1)C#N	InChI=1S/C34H34N6O3/c35-19-23-1-3-25(4-2-23)22-39-15-13-27(14-16-39)38-33(41)32-12-7-26(21-37-32)34(42)40-28-8-9-29(40)18-31(17-28)43-30-10-5-24(20-36)6-11-30/h1-7,10-12,21,27-29,31H,8-9,13-18,22H2,(H,38,41)	HVGKNJVYYFTFOB-UHFFFAOYSA-N	328142	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-((1R,3r,5S)-3-(4- cyanophenoxy)-8- azabicyclo[3.2.1]octane- 8-carbonyl)picolinamide::US10377742, Compound 280::US9663496, Compound 280	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328142&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			77175293	384583057							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644348	Fc1ccc(cc1F)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F2N5O3/c33-27-7-5-24(17-28(27)34)30(40)23-9-15-39(16-10-23)32(42)25-6-8-29(36-19-25)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	RVVFUTBGTJOJLC-UHFFFAOYSA-N	328143	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,4- difluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 281::US9663496, Compound 281	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328143&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710359	384583058							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644349	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C31H31F2N5O3/c32-24-6-8-29(27(33)17-24)41-26-11-15-38(16-12-26)31(40)23-5-7-28(35-19-23)30(39)36-25-9-13-37(14-10-25)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,25-26H,9-16,20H2,(H,36,39)	NTZCHZCFSJZAQG-UHFFFAOYSA-N	328144	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 282::US9663496, Compound 282	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328144&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710344	384583059							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644350	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1cccnc1	InChI=1S/C30H32N6O3/c31-18-22-3-5-23(6-4-22)21-35-14-9-25(10-15-35)34-29(37)28-8-7-24(19-33-28)30(38)36-16-11-26(12-17-36)39-27-2-1-13-32-20-27/h1-8,13,19-20,25-26H,9-12,14-17,21H2,(H,34,37)	WOYQNFWVHGYKBX-UHFFFAOYSA-N	328145	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(pyridin-3- yloxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 283::US9663496, Compound 283	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328145&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710446	384583060							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644351	CCOC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C34H37N5O5/c1-2-43-34(42)26-7-10-29(11-8-26)44-30-15-19-39(20-16-30)33(41)27-9-12-31(36-22-27)32(40)37-28-13-17-38(18-14-28)23-25-5-3-24(21-35)4-6-25/h3-12,22,28,30H,2,13-20,23H2,1H3,(H,37,40)	QBCOHMKIOZPEPA-UHFFFAOYSA-N	328146	US10377742, Compound 284::US9663496, Compound 284::ethyl 4-(1-(6-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)nicotinoyl)  piperidin-4- yloxy)benzoate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328146&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710564	384583061							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644352	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O3/c1-41-29-9-6-26(7-10-29)22-36-14-12-28(13-15-36)35-31(39)30-11-8-27(21-34-30)32(40)38-18-16-37(17-19-38)23-25-4-2-24(20-33)3-5-25/h2-11,21,28H,12-19,22-23H2,1H3,(H,35,39)	ZSDOZPPRAYGYEU-UHFFFAOYSA-N	328147	5-(4-(4- cyanobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 285::US9663496, Compound 285	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328147&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710495	384583062							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644353	COc1cc(ccc1OC1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C#N	InChI=1S/C32H34N6O3/c1-40-31-18-25(20-34)6-9-30(31)41-28-12-16-38(17-13-28)27-7-8-29(35-21-27)32(39)36-26-10-14-37(15-11-26)22-24-4-2-23(19-33)3-5-24/h2-9,18,21,26,28H,10-17,22H2,1H3,(H,36,39)	VHMVZBCHWOEJTQ-UHFFFAOYSA-N	328148	5-(4-(4-cyano-2- methoxyphenoxy)  piperidin-1-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 286::US9663496, Compound 286	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328148&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710506	384583063							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644354	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C32H34F2N4O4/c1-42-28-5-2-22(3-6-28)30(39)23-8-14-38(15-9-23)32(41)24-4-7-29(35-19-24)31(40)36-27-10-12-37(13-11-27)20-21-16-25(33)18-26(34)17-21/h2-7,16-19,23,27H,8-15,20H2,1H3,(H,36,40)	PQSYSUQLVSDROG-UHFFFAOYSA-N	328149	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 287::US9663496, Compound 287	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328149&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710486	384583064							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644355	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C31H31F3N4O3/c32-24-4-1-21(2-5-24)29(39)22-7-13-38(14-8-22)31(41)23-3-6-28(35-18-23)30(40)36-27-9-11-37(12-10-27)19-20-15-25(33)17-26(34)16-20/h1-6,15-18,22,27H,7-14,19H2,(H,36,40)	RAFLQQGXFCLPCT-UHFFFAOYSA-N	328150	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 288::US9663496, Compound 288	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328150&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710815	384583065							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644356	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)c1	InChI=1S/C31H31F2N5O3/c32-24-15-22(16-25(33)17-24)20-37-11-7-26(8-12-37)36-30(39)29-6-3-23(19-35-29)31(40)38-13-9-28(10-14-38)41-27-4-1-21(18-34)2-5-27/h1-6,15-17,19,26,28H,7-14,20H2,(H,36,39)	SGEPABNOVNCCBC-UHFFFAOYSA-N	328151	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 289::US9663496, Compound 289	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328151&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710422	384583066							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644357	CC(C)(C)OC(=O)NCCCc1cc(cnc1C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C39H48FN7O4/c1-39(2,3)51-38(50)42-16-4-5-31-23-32(37(49)47-21-19-46(20-22-47)27-30-10-12-33(40)13-11-30)25-43-35(31)36(48)44-34-14-17-45(18-15-34)26-29-8-6-28(24-41)7-9-29/h6-13,23,25,34H,4-5,14-22,26-27H2,1-3H3,(H,42,50)(H,44,48)	HWTMPFJOXKCYBU-UHFFFAOYSA-N	328152	US10377742, Compound 290::US9663496, Compound 290::tert-butyl 3-(2-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-3- yl)propylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328152&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710277	384583067							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644358	Fc1ccc(CN2CCN(CC2)C(=O)c2cnc(C(=O)NC3CCN(Cc4ccc(cc4)C#N)CC3)c(CCCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]3SCC4NC(=O)NC34)c2)cc1	InChI=1S/C55H75FN10O9S/c56-45-13-11-42(12-14-45)38-65-22-24-66(25-23-65)54(70)44-34-43(51(60-36-44)53(69)61-46-15-20-64(21-16-46)37-41-9-7-40(35-57)8-10-41)4-3-18-58-50(68)17-26-72-28-30-74-32-33-75-31-29-73-27-19-59-49(67)6-2-1-5-48-52-47(39-76-48)62-55(71)63-52/h7-14,34,36,46-48,52H,1-6,15-33,37-39H2,(H,58,68)(H,59,67)(H,61,69)(H2,62,63,71)/t47?,48-,52?/m0/s1	WPSSXRQGFUCSRU-BUHZPHELSA-N	328153	N-(1-(4- cyanobenzyl)piperidin-4- yl)-3-(5,21-dioxo-25- ((3aS,4S,6aR)-2- oxohexahydro-lH- thieno[3,4-d]imidazol-4- yl)-8,11,14,17-tetraoxa- 4,20-diazapentacosyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 291::US9663496, Compound 291	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328153&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			89737193	384583068							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644359	Fc1ccc(OC2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C29H29F3N4O3/c30-21-2-4-25(5-3-21)39-26-9-12-36(18-26)29(38)20-1-6-27(33-16-20)28(37)34-24-7-10-35(11-8-24)17-19-13-22(31)15-23(32)14-19/h1-6,13-16,24,26H,7-12,17-18H2,(H,34,37)	ADMHSPDKZAALOS-UHFFFAOYSA-N	328154	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-((S)-3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 292::US9663496, Compound 292	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328154&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710429	384583069							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644360	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O3/c1-21-2-5-27(6-3-21)40-28-10-14-37(15-11-28)31(39)23-4-7-29(34-19-23)30(38)35-26-8-12-36(13-9-26)20-22-16-24(32)18-25(33)17-22/h2-7,16-19,26,28H,8-15,20H2,1H3,(H,35,38)	HDGCNHRJTDVRSF-UHFFFAOYSA-N	328155	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(p- tolyloxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 293::US9663496, Compound 293	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328155&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073179	384583070							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644361	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)c1	InChI=1S/C31H31F5N4O3/c32-23-15-20(16-24(33)17-23)19-39-11-7-25(8-12-39)38-29(41)28-6-1-21(18-37-28)30(42)40-13-9-27(10-14-40)43-26-4-2-22(3-5-26)31(34,35)36/h1-6,15-18,25,27H,7-14,19H2,(H,38,41)	APBUQRJICSRSSS-UHFFFAOYSA-N	328156	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 294::US9663496, Compound 294	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328156&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710472	384583071							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644362	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C30H31F3N4O3/c31-22-2-4-26(5-3-22)40-27-9-13-37(14-10-27)30(39)21-1-6-28(34-18-21)29(38)35-25-7-11-36(12-8-25)19-20-15-23(32)17-24(33)16-20/h1-6,15-18,25,27H,7-14,19H2,(H,35,38)	QPCNUSNHBFCPAM-UHFFFAOYSA-N	328157	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 295::US9663496, Compound 295	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328157&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710661	384583072							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644363	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O4/c1-40-26-3-5-27(6-4-26)41-28-10-14-37(15-11-28)31(39)22-2-7-29(34-19-22)30(38)35-25-8-12-36(13-9-25)20-21-16-23(32)18-24(33)17-21/h2-7,16-19,25,28H,8-15,20H2,1H3,(H,35,38)	HIVGHAUHDXNYQB-UHFFFAOYSA-N	328158	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 296::US9663496, Compound 296	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328158&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710188	384583073							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644364	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)c(F)c2)c1	InChI=1S/C30H30F4N4O3/c31-21-13-19(14-22(32)15-21)18-37-9-5-23(6-10-37)36-29(39)28-4-1-20(17-35-28)30(40)38-11-7-24(8-12-38)41-25-2-3-26(33)27(34)16-25/h1-4,13-17,23-24H,5-12,18H2,(H,36,39)	DTDPXJTYCFTEEW-UHFFFAOYSA-N	328159	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(3,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 297::US9663496, Compound 297	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328159&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710719	384583074							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644365	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)c(F)c2)c1	InChI=1S/C31H30F4N4O3/c32-23-13-19(14-24(33)16-23)18-38-9-7-25(8-10-38)37-30(41)28-4-2-22(17-36-28)31(42)39-11-5-20(6-12-39)29(40)21-1-3-26(34)27(35)15-21/h1-4,13-17,20,25H,5-12,18H2,(H,37,41)	DLBGZVFJKSQFKW-UHFFFAOYSA-N	328160	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 298::US9663496, Compound 298	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328160&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710420	384583075							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644366	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CC[C@@H](CC1)Oc1cc(F)cc(F)c1	InChI=1S/C31H30F3N3O4/c32-22-4-1-19(2-5-22)29(38)20-11-13-37(14-12-20)31(40)21-3-10-28(35-18-21)30(39)36-25-6-8-26(9-7-25)41-27-16-23(33)15-24(34)17-27/h1-5,10,15-18,20,25-26H,6-9,11-14H2,(H,36,39)/t25?,26-	AEVUGAVYMLUBMI-JMOIINNLSA-N	328161	N-((cis)-4-(3,5- difluorophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 299	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328161&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486205	384583076							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644367	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CC[C@@H](CC1)Oc1cc(F)cc(F)c1	InChI=1S/C32H33F2N3O5/c1-41-26-7-2-20(3-8-26)30(38)21-12-14-37(15-13-21)32(40)22-4-11-29(35-19-22)31(39)36-25-5-9-27(10-6-25)42-28-17-23(33)16-24(34)18-28/h2-4,7-8,11,16-19,21,25,27H,5-6,9-10,12-15H2,1H3,(H,36,39)/t25?,27-	WUUYOPINRPLTPV-BRCTUYKBSA-N	328162	N-((cis)-4-(3,5- difluorophenoxy)  cyclohexyl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 300	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328162&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710704	384583077							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644368	FC(F)(F)c1ccc(OC2CCN(CC2)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F3N5O2/c32-31(33,34)24-5-8-27(9-6-24)41-28-13-17-39(18-14-28)26-7-10-29(36-20-26)30(40)37-25-11-15-38(16-12-25)21-23-3-1-22(19-35)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,37,40)	JHRNQZYMFIIVGE-UHFFFAOYSA-N	328163	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)picolinamide::US10377742, Compound 301::US9663496, Compound 301	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328163&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710654	384583078							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644369	COc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H35N5O3/c1-40-29-9-6-25(7-10-29)31(38)26-12-18-37(19-13-26)28-8-11-30(34-21-28)32(39)35-27-14-16-36(17-15-27)22-24-4-2-23(20-33)3-5-24/h2-11,21,26-27H,12-19,22H2,1H3,(H,35,39)	HVAFECNXPDQFSX-UHFFFAOYSA-N	328164	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidin-1- yl)picolinamide::US10377742, Compound 302::US9663496, Compound 302	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328164&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710614	384583079							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644370	Fc1ccc(O[C@H]2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)39-27-12-6-24(7-13-27)35-30(37)29-14-3-22(20-34-29)31(38)36-17-15-28(16-18-36)40-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24?,27-	XZNBTHWUHWCAHY-ITADFGRYSA-N	328165	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)picolinamide::US9663496, Compound 303	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328165&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710712	384583080							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644371	Fc1ccc(O[C@H]2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1	InChI=1S/C31H31F2N3O4/c32-23-4-1-20(2-5-23)29(37)21-15-17-36(18-16-21)31(39)22-3-14-28(34-19-22)30(38)35-25-8-12-27(13-9-25)40-26-10-6-24(33)7-11-26/h1-7,10-11,14,19,21,25,27H,8-9,12-13,15-18H2,(H,35,38)/t25?,27-	UQXVMWQFDDWKBT-BRCTUYKBSA-N	328166	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)picolinamide::US9663496, Compound 304	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328166&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710524	384583081							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644372	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NCCOc1ccc(F)cc1	InChI=1S/C28H28FN3O5/c1-36-23-7-2-19(3-8-23)26(33)20-12-15-32(16-13-20)28(35)21-4-11-25(31-18-21)27(34)30-14-17-37-24-9-5-22(29)6-10-24/h2-11,18,20H,12-17H2,1H3,(H,30,34)	MLGAAABCCVIOEF-UHFFFAOYSA-N	328167	N-(2-(4- fluorophenoxy)ethyl)-5- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 305::US9663496, Compound 305	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328167&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710253	384583082							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644373	Fc1ccc(OCCNC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C27H25FN4O4/c28-21-4-8-22(9-5-21)35-16-13-30-26(33)25-10-3-20(18-31-25)27(34)32-14-11-24(12-15-32)36-23-6-1-19(17-29)2-7-23/h1-10,18,24H,11-16H2,(H,30,33)	ZSPDVYPDGBHLED-UHFFFAOYSA-N	328168	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(2-(4- fluorophenoxy)ethyl)  picolinamide::US10377742, Compound 306::US9663496, Compound 306	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328168&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710370	384583083							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644374	Fc1ccc(COC2CN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-25-8-5-23(6-9-25)20-39-27-18-36(19-27)30(38)24-7-10-28(33-16-24)29(37)34-26-11-13-35(14-12-26)17-22-3-1-21(15-32)2-4-22/h1-10,16,26-27H,11-14,17-20H2,(H,34,37)	JUPFXDZHGLSJJR-UHFFFAOYSA-N	328169	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorobenzyloxy)  azetidine-1- carbonyl)picolinamide::US10377742, Compound 307::US9663496, Compound 307	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328169&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710407	384583084							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644375	Fc1ccc(COC2CN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C29H29F3N4O3/c30-22-4-1-19(2-5-22)18-39-26-16-36(17-26)29(38)21-3-6-27(33-14-21)28(37)34-25-7-9-35(10-8-25)15-20-11-23(31)13-24(32)12-20/h1-6,11-14,25-26H,7-10,15-18H2,(H,34,37)	JTXPMIJNGKYFRZ-UHFFFAOYSA-N	328170	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(3-(4- fluorobenzyloxy)  azetidine-1- carbonyl)picolinamide::US10377742, Compound 308::US9663496, Compound 308	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328170&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710575	384583085							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644376	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)30-11-8-27(21-35-30)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	JKGJLUCJLNJXKG-UHFFFAOYSA-N	328171	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 309::US9663496, Compound 309	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328171&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710293	384583086							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644377	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C32H34F2N4O4/c1-42-28-5-2-22(3-6-28)30(39)23-8-14-38(15-9-23)32(41)29-7-4-24(19-35-29)31(40)36-27-10-12-37(13-11-27)20-21-16-25(33)18-26(34)17-21/h2-7,16-19,23,27H,8-15,20H2,1H3,(H,36,40)	HFGMPLDTNKSDKF-UHFFFAOYSA-N	328172	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 310::US9663496, Compound 310	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328172&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710633	384583087							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644378	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CC[C@@H](CC1)Oc1ccc(F)cc1	InChI=1S/C32H34FN3O5/c1-40-26-9-2-21(3-10-26)30(37)22-16-18-36(19-17-22)32(39)23-4-15-29(34-20-23)31(38)35-25-7-13-28(14-8-25)41-27-11-5-24(33)6-12-27/h2-6,9-12,15,20,22,25,28H,7-8,13-14,16-19H2,1H3,(H,35,38)/t25?,28-	DDIKEHGCFSSELH-WQBPAFKJSA-N	328173	N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 311	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328173&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710582	384583088							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644379	Fc1ccc(O[C@H]2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C30H31F2N3O4/c31-21-2-8-24(9-3-21)38-26-12-6-23(7-13-26)34-29(36)28-14-1-20(19-33-28)30(37)35-17-15-27(16-18-35)39-25-10-4-22(32)5-11-25/h1-5,8-11,14,19,23,26-27H,6-7,12-13,15-18H2,(H,34,36)/t23?,26-	VGTANERTDXIGKZ-OMWPTYOUSA-N	328174	N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US9663496, Compound 312	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328174&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710648	384583089							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644380	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CC(C2)Oc2ccc(cc2)C#N)c1	InChI=1S/C29H27F2N5O3/c30-22-11-20(12-23(31)13-22)16-35-9-7-24(8-10-35)34-28(37)27-6-3-21(15-33-27)29(38)36-17-26(18-36)39-25-4-1-19(14-32)2-5-25/h1-6,11-13,15,24,26H,7-10,16-18H2,(H,34,37)	OALQOHPDGYLZQW-UHFFFAOYSA-N	328175	5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)-N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 313::US9663496, Compound 313	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328175&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710675	384583090							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644381	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCn3c(C2)nnc3-c2ccc(cc2)C#N)c1	InChI=1S/C31H28F2N8O2/c32-24-13-21(14-25(33)15-24)18-39-9-7-26(8-10-39)36-30(42)27-6-5-23(17-35-27)31(43)40-11-12-41-28(19-40)37-38-29(41)22-3-1-20(16-34)2-4-22/h1-6,13-15,17,26H,7-12,18-19H2,(H,36,42)	BYINZUBHGSJUSR-UHFFFAOYSA-N	328176	5-(3-(4-cyanophenyl)- 5,6,7,8-tetrahydro- [1,2,4]triazolo[4,3- a]pyrazine-7-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 314::US9663496, Compound 314	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328176&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710319	384583091							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644382	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CC[C@@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C33H34N4O5/c1-41-27-11-4-23(5-12-27)31(38)24-16-18-37(19-17-24)33(40)30-15-6-25(21-35-30)32(39)36-26-7-13-29(14-8-26)42-28-9-2-22(20-34)3-10-28/h2-6,9-12,15,21,24,26,29H,7-8,13-14,16-19H2,1H3,(H,36,39)/t26?,29-	BUASOVJVWXZVAK-MXLLDWDMSA-N	328177	N-((1s,4s)-4-(4- cyanophenoxy)  cyclohexyl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 315	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328177&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710440	384583092							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644383	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CC[C@@H](CC1)Oc1ccc(F)cc1	InChI=1S/C32H34FN3O5/c1-40-26-9-2-21(3-10-26)30(37)22-16-18-36(19-17-22)32(39)29-15-4-23(20-34-29)31(38)35-25-7-13-28(14-8-25)41-27-11-5-24(33)6-12-27/h2-6,9-12,15,20,22,25,28H,7-8,13-14,16-19H2,1H3,(H,35,38)/t25?,28-	POSQDFRYAYRMHL-WQBPAFKJSA-N	328178	N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 316	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328178&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710343	384583093							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644384	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)29-11-6-25(20-34-29)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	KNIWBJVPMSYDST-UHFFFAOYSA-N	328179	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 317::US9663496, Compound 317	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328179&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710269	384583094							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644385	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C33H38N4O5/c1-41-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)26-7-12-30(34-21-26)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(42-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	XGFSPOXBSRLZDO-UHFFFAOYSA-N	328180	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 318::US9663496, Compound 318	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328180&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710519	384583095							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644386	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-4-24(5-8-27)22-36-16-12-26(13-17-36)35-31(38)25-6-11-30(34-21-25)32(39)37-18-14-29(15-19-37)41-28-9-2-23(20-33)3-10-28/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	KBPBPTZMSUNTBK-UHFFFAOYSA-N	328181	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 319::US9663496, Compound 319	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328181&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710665	384583096							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644387	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-11-26(12-16-36)35-30(38)24-5-10-29(34-20-24)31(39)37-17-13-28(14-18-37)40-27-8-3-22(19-33)4-9-27/h1-10,20,26,28H,11-18,21H2,(H,35,38)	CJNVQFBBNTVLGQ-UHFFFAOYSA-N	328182	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 320::US9663496, Compound 320	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328182&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710562	384583097							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644388	O=C(NC1CC[C@@H](CC1)Oc1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31N5O4/c33-19-22-1-8-26(9-2-22)40-28-12-6-25(7-13-28)36-31(38)24-5-14-30(35-21-24)32(39)37-17-15-29(16-18-37)41-27-10-3-23(20-34)4-11-27/h1-5,8-11,14,21,25,28-29H,6-7,12-13,15-18H2,(H,36,38)/t25?,28-	QXYDKUCICQMFKB-WQBPAFKJSA-N	328183	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 321	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328183&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710423	384583098							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644389	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)c1	InChI=1S/C31H31F2N5O3/c32-24-15-22(16-25(33)17-24)20-37-11-7-26(8-12-37)36-30(39)23-3-6-29(35-19-23)31(40)38-13-9-28(10-14-38)41-27-4-1-21(18-34)2-5-27/h1-6,15-17,19,26,28H,7-14,20H2,(H,36,39)	DVERKLBRNMUJHI-UHFFFAOYSA-N	328184	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 322::US9663496, Compound 322	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328184&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710490	384583099							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644390	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)26-7-10-30(35-21-26)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)	ZXOKHOODFVNZIC-UHFFFAOYSA-N	328185	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 323::US9663496, Compound 323	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328185&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710645	384583100							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644391	Fc1ccc(O[C@H]2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)39-27-12-6-24(7-13-27)35-30(37)22-3-14-29(34-20-22)31(38)36-17-15-28(16-18-36)40-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24?,27-	ODCYZWPLGOHHLR-ITADFGRYSA-N	328186	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-((cis)-4-(4- fluorophenoxy)  cyclohexyl)nicotinamide::US9663496, Compound 324	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328186&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710505	384583101							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644392	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O5/c1-40-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)27-12-4-22(18-33-27)30(38)35-24-7-13-28(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	XYFIPKRIPGHVQF-UHFFFAOYSA-N	328187	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 325::US9663496, Compound 325	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328187&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710529	384583102							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644393	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C#N)cn2)cc1	InChI=1S/C30H24FN5O4/c31-22-4-9-25(10-5-22)40-28-12-6-23(19-34-28)35-29(37)21-3-11-27(33-18-21)30(38)36-15-13-26(14-16-36)39-24-7-1-20(17-32)2-8-24/h1-12,18-19,26H,13-16H2,(H,35,37)	XSUNUTFPDUBUTM-UHFFFAOYSA-N	328188	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 326::US9663496, Compound 326	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328188&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710283	384583103							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644394	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H36FN5O3/c1-40-28-9-4-24(5-10-28)21-35-14-12-27(13-15-35)34-30(38)25-6-11-29(33-20-25)31(39)37-18-16-36(17-19-37)22-23-2-7-26(32)8-3-23/h2-11,20,27H,12-19,21-22H2,1H3,(H,34,38)	OUYBMULCCUWUIY-UHFFFAOYSA-N	328189	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 327::US9663496, Compound 327	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328189&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710301	384583104							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644395	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C30H33F2N5O2/c31-25-6-1-22(2-7-25)20-35-13-11-27(12-14-35)34-29(38)24-5-10-28(33-19-24)30(39)37-17-15-36(16-18-37)21-23-3-8-26(32)9-4-23/h1-10,19,27H,11-18,20-21H2,(H,34,38)	JKAJRLZIQKBLFQ-UHFFFAOYSA-N	328190	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 328::US9663496, Compound 328	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328190&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710463	384583105							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644396	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)c(F)c2)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)29-9-5-24(19-35-29)32(41)38-16-10-22(11-17-38)30(39)23-4-8-27(33)28(34)18-23/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	NJOONPNZPKPCKC-UHFFFAOYSA-N	328191	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 329::US9663496, Compound 329	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328191&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710605	384583106							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644397	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)c(F)c3)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-21-3-6-23(7-4-21)41-27-10-5-22(17-35-27)36-29(39)26-9-2-20(16-34-26)30(40)37-13-11-18(12-14-37)28(38)19-1-8-24(32)25(33)15-19/h1-10,15-18H,11-14H2,(H,36,39)	RNONESCEJJROHR-UHFFFAOYSA-N	328192	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 330::US9663496, Compound 330	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328192&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710435	384583107							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644398	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)29-9-4-23(19-35-29)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	MYYQGOANVIXKIS-UHFFFAOYSA-N	328193	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 331::US9663496, Compound 331	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328193&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710337	384583108							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644399	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CC[C@@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)29-14-5-24(20-34-29)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-7,10-11,14,20,26,28H,8-9,12-13,15-18,21H2,(H,35,38)/t26?,28-	QMTWAPVKHUNKFZ-DVFXULFPSA-N	328194	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US9663496, Compound 332	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328194&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710663	384583109							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644400	CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C29H35N5O5/c1-29(2,3)39-28(37)34-14-10-22(11-15-34)32-26(35)21-6-9-25(31-19-21)27(36)33-16-12-24(13-17-33)38-23-7-4-20(18-30)5-8-23/h4-9,19,22,24H,10-17H2,1-3H3,(H,32,35)	BJGOHBYNVRHYBW-UHFFFAOYSA-N	328195	US10377742, Compound 333::US9663496, Compound 333::tert-butyl 4-(6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)nicotinamido)  piperidine-1-carboxylate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328195&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710352	384583110							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644401	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-22-4-1-20(2-5-22)19-35-13-15-36(16-14-35)29(38)26-11-3-21(17-32-26)28(37)34-24-8-12-27(33-18-24)39-25-9-6-23(31)7-10-25/h1-12,17-18H,13-16,19H2,(H,34,37)	HOYLOGISDOAXOM-UHFFFAOYSA-N	328196	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 334::US9663496, Compound 334	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328196&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710607	384583111							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644402	O=C(NC1CCNCC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C24H27N5O3/c25-15-17-1-4-20(5-2-17)32-21-9-13-29(14-10-21)24(31)22-6-3-18(16-27-22)23(30)28-19-7-11-26-12-8-19/h1-6,16,19,21,26H,7-14H2,(H,28,30)	QLERZABOMGLECS-UHFFFAOYSA-N	328197	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(piperidin-4- yl)nicotinamide::US10377742, Compound 335::US9663496, Compound 335	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328197&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710756	384583112							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644403	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O3/c36-23-26-5-10-31(11-6-26)44-32-15-21-41(22-16-32)35(43)33-12-7-28(24-37-33)34(42)38-29-13-19-39(20-14-29)25-27-3-8-30(9-4-27)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)	ZWSIGMIBWASNND-UHFFFAOYSA-N	328198	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 336::US9663496, Compound 336	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328198&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710563	384583113							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644404	O=C(NC1CCN(Cc2ccc(cc2)N2CCOCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O4/c36-23-26-3-8-31(9-4-26)45-32-13-17-41(18-14-32)35(43)33-10-5-28(24-37-33)34(42)38-29-11-15-39(16-12-29)25-27-1-6-30(7-2-27)40-19-21-44-22-20-40/h1-10,24,29,32H,11-22,25H2,(H,38,42)	FKPBNJOZUYPWPE-UHFFFAOYSA-N	328199	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- morpholinobenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 337::US9663496, Compound 337	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328199&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710674	384583114							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644405	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H32F3N5O4/c33-32(34,35)44-28-8-3-23(4-9-28)21-39-15-11-25(12-16-39)38-30(41)24-5-10-29(37-20-24)31(42)40-17-13-27(14-18-40)43-26-6-1-22(19-36)2-7-26/h1-10,20,25,27H,11-18,21H2,(H,38,41)	DSZCBNUFKPZERX-UHFFFAOYSA-N	328200	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 338::US9663496, Compound 338	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328200&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710640	384583115							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644406	FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31F3N6O2/c32-31(33,34)25-6-8-27(9-7-25)39-15-17-40(18-16-39)30(42)24-5-10-28(36-20-24)29(41)37-26-11-13-38(14-12-26)21-23-3-1-22(19-35)2-4-23/h1-10,20,26H,11-18,21H2,(H,37,41)	ZRFMAUMUQYAFKO-UHFFFAOYSA-N	328201	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)phenyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 339::US9663496, Compound 339	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328201&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			53476411	384583116							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644407	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)C#N	InChI=1S/C31H31N7O2/c32-19-23-1-3-25(4-2-23)22-36-13-11-27(12-14-36)35-30(39)29-10-7-26(21-34-29)31(40)38-17-15-37(16-18-38)28-8-5-24(20-33)6-9-28/h1-10,21,27H,11-18,22H2,(H,35,39)	SVZYBPGZXSSLEB-UHFFFAOYSA-N	328202	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenyl)piperazne- 1-carbonyl)picolinamide::US10377742, Compound 340::US9663496, Compound 340	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328202&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			53476410	384583117							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644408	Fc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H31FN6O2/c31-25-6-8-27(9-7-25)36-15-17-37(18-16-36)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-35(14-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,26H,11-18,21H2,(H,34,38)	KAPJCNOKYHCMQW-UHFFFAOYSA-N	328203	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 341::US9663496, Compound 341	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328203&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710406	384583118							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644409	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-20-2-6-23(7-3-20)41-27-10-5-22(17-35-27)36-29(39)26-9-1-19(16-34-26)30(40)37-13-11-18(12-14-37)28(38)24-8-4-21(32)15-25(24)33/h1-10,15-18H,11-14H2,(H,36,39)	QGQJHZASQZDJMZ-UHFFFAOYSA-N	328204	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 342::US9663496, Compound 342	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328204&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710716	384583119							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644410	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(F)cc3F)cn2)cc1	InChI=1S/C29H23F3N4O4/c30-19-2-6-22(7-3-19)40-27-10-5-21(17-34-27)35-28(37)18-1-8-25(33-16-18)29(38)36-13-11-23(12-14-36)39-26-9-4-20(31)15-24(26)32/h1-10,15-17,23H,11-14H2,(H,35,37)	GUJSBGWSDRFUAC-UHFFFAOYSA-N	328205	6-(4-(2,4- difluorophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 343::US9663496, Compound 343	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328205&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710555	384583120							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644411	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2F)cc1	InChI=1S/C31H34F2N4O4/c1-40-25-6-2-21(3-7-25)20-36-14-10-24(11-15-36)35-30(38)22-4-8-28(34-19-22)31(39)37-16-12-26(13-17-37)41-29-9-5-23(32)18-27(29)33/h2-9,18-19,24,26H,10-17,20H2,1H3,(H,35,38)	XRBKWKWORRIBMT-UHFFFAOYSA-N	328206	6-(4-(2,4- difluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 344::US9663496, Compound 344	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328206&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710858	384583121							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644412	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C31H31F2N5O3/c32-24-6-8-29(27(33)17-24)41-26-11-15-38(16-12-26)31(40)28-7-5-23(19-35-28)30(39)36-25-9-13-37(14-10-25)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,25-26H,9-16,20H2,(H,36,39)	CQZOSLVFDRPCFJ-UHFFFAOYSA-N	328207	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2,4- difluorophenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 345::US9663496, Compound 345	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328207&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710857	384583122							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644413	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)29-8-5-24(19-36-29)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	CZGHJHFJDOKLEU-UHFFFAOYSA-N	328208	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 346::US9663496, Compound 346	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328208&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710841	384583123							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644414	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)23-4-9-29(35-19-23)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	SNUABOBOUCELJX-UHFFFAOYSA-N	328209	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 347::US9663496, Compound 347	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328209&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710714	384583124							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644415	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-20-2-6-23(7-3-20)41-27-10-5-22(17-35-27)36-29(39)19-1-9-26(34-16-19)30(40)37-13-11-18(12-14-37)28(38)24-8-4-21(32)15-25(24)33/h1-10,15-18H,11-14H2,(H,36,39)	MMDHXUCOBFMXDW-UHFFFAOYSA-N	328210	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 348::US9663496, Compound 348	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328210&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710581	384583125							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644416	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29?/m1/s1	LEUSDRGCPVXECX-FICMROCWSA-N	328211	N-((trans)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 349	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328211&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084300	384583126							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644417	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@H]1F	InChI=1S/C33H34F4N4O5/c1-45-25-9-4-22(5-10-25)30(42)23-12-16-41(17-13-23)32(44)29-11-6-24(18-38-29)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-26(8-3-21)46-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28?/m1/s1	HWOSDYNCBXZMQP-QXPUDEPPSA-N	328212	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)  benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 350	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328212&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084307	384583127							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644418	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C30H31N7O2/c31-19-22-1-3-24(4-2-22)21-36-15-11-25(12-16-36)33-30(38)28-9-10-29(35-34-28)37-17-13-27(14-18-37)39-26-7-5-23(20-32)6-8-26/h1-10,25,27H,11-18,21H2,(H,33,38)	NSZYFVPQFQAZIY-UHFFFAOYSA-N	328213	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- cyanophenoxy)piperidin- 1-yl)pyridazine-3- carboxamide::US10377742, Compound 351::US9663496, Compound 351	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328213&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710647	384583128							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644419	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)C[C@H]1F	InChI=1S/C36H42FN5O4/c1-46-30-11-6-26(7-12-30)34(43)27-14-20-42(21-15-27)36(45)33-13-8-28(22-38-33)35(44)39-32-16-19-40(24-31(32)37)23-25-4-9-29(10-5-25)41-17-2-3-18-41/h4-13,22,27,31-32H,2-3,14-21,23-24H2,1H3,(H,39,44)/t31-,32?/m1/s1	GMBOADRJUJIWFX-XGDNGBMYSA-N	328214	N-((trans)-3-fluoro-1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 352	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328214&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084556	384583129							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644420	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(C)C)cc2)C[C@H]1F	InChI=1S/C35H41FN4O5/c1-23(2)45-29-9-4-24(5-10-29)21-39-17-16-31(30(36)22-39)38-34(42)27-8-13-32(37-20-27)35(43)40-18-14-26(15-19-40)33(41)25-6-11-28(44-3)12-7-25/h4-13,20,23,26,30-31H,14-19,21-22H2,1-3H3,(H,38,42)/t30-,31?/m1/s1	MPRAAOIVYGMJKJ-PBBFAOSKSA-N	328215	N-((trans)-3-fluoro-1-(4- isopropoxybenzyl)  piperidin-4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 353	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328215&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084727	384583130							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644421	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(C#N)c(F)c2)C[C@H]1F	InChI=1S/C33H33F2N5O4/c1-44-26-7-4-22(5-8-26)31(41)23-10-14-40(15-11-23)33(43)30-9-6-25(18-37-30)32(42)38-29-12-13-39(20-28(29)35)19-21-2-3-24(17-36)27(34)16-21/h2-9,16,18,23,28-29H,10-15,19-20H2,1H3,(H,38,42)/t28-,29?/m1/s1	XSTWHJANPVSKRP-FICMROCWSA-N	328216	N-((trans)-1-(4-cyano-3- fluorobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US9663496, Compound 354	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328216&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084558	384583131							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644422	O=C(NC1CCN(Cc2cocn2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C28H30N6O4/c29-15-20-1-4-24(5-2-20)38-25-9-13-34(14-10-25)28(36)26-6-3-21(16-30-26)27(35)32-22-7-11-33(12-8-22)17-23-18-37-19-31-23/h1-6,16,18-19,22,25H,7-14,17H2,(H,32,35)	MZHVANYWYUEJSQ-UHFFFAOYSA-N	328217	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(oxazol-4- ylmethyl)piperidin-4- yl)nicotinamide::US10377742, Compound 355::US9663496, Compound 355	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328217&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710394	384583132							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644423	O=C(NC1CCN(Cc2nccs2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C28H30N6O3S/c29-17-20-1-4-23(5-2-20)37-24-9-14-34(15-10-24)28(36)25-6-3-21(18-31-25)27(35)32-22-7-12-33(13-8-22)19-26-30-11-16-38-26/h1-6,11,16,18,22,24H,7-10,12-15,19H2,(H,32,35)	SMBYEQDVWMFBTL-UHFFFAOYSA-N	328218	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(thiazol-2- ylmethyl)piperidin-4- yl)nicotinamide::US10377742, Compound 356::US9663496, Compound 356	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328218&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710626	384583133							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644424	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C34H38N6O4/c1-38(2)33(42)26-7-10-29(11-8-26)44-30-15-19-40(20-16-30)34(43)27-9-12-31(36-22-27)32(41)37-28-13-17-39(18-14-28)23-25-5-3-24(21-35)4-6-25/h3-12,22,28,30H,13-20,23H2,1-2H3,(H,37,41)	HUYCPHYFJJCRHE-UHFFFAOYSA-N	328219	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 357::US9663496, Compound 357	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328219&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710491	384583134							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644425	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H35N5O4/c1-23(39)26-6-9-29(10-7-26)42-30-14-18-38(19-15-30)33(41)27-8-11-31(35-21-27)32(40)36-28-12-16-37(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)	CGANLALLTGBPTO-UHFFFAOYSA-N	328220	5-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 358::US9663496, Compound 358	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328220&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710604	384583135							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644426	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)22-4-12-28(33-18-22)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	UGQQVZAGWFGYST-UHFFFAOYSA-N	328221	5-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 359::US9663496, Compound 359	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328221&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710752	384583136							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644427	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C32H30FN5O5/c1-37(2)31(40)21-3-9-25(10-4-21)42-27-15-17-38(18-16-27)32(41)22-5-13-28(34-19-22)30(39)36-24-8-14-29(35-20-24)43-26-11-6-23(33)7-12-26/h3-14,19-20,27H,15-18H2,1-2H3,(H,36,39)	BBMMNIYHXIHSPL-UHFFFAOYSA-N	328222	5-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 360::US9663496, Compound 360	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328222&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710272	384583137							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644428	FC(F)(F)c1ccc(OC2CCN(CC2)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H31F3N6O2/c31-30(32,33)23-5-7-25(8-6-23)41-26-13-17-39(18-14-26)28-10-9-27(36-37-28)29(40)35-24-11-15-38(16-12-24)20-22-3-1-21(19-34)2-4-22/h1-10,24,26H,11-18,20H2,(H,35,40)	YTSTYPROPVLXLB-UHFFFAOYSA-N	328223	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)pyridazine-3- carboxamide::US10377742, Compound 361::US9663496, Compound 361	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328223&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710281	384583138							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644429	COc1ccc(OC2CCN(CC2)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H34N6O3/c1-38-25-6-8-26(9-7-25)39-27-14-18-36(19-15-27)29-11-10-28(33-34-29)30(37)32-24-12-16-35(17-13-24)21-23-4-2-22(20-31)3-5-23/h2-11,24,27H,12-19,21H2,1H3,(H,32,37)	NLAAJZRIRDYYDE-UHFFFAOYSA-N	328224	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidin-1- yl)pyridazine-3- carboxamide::US9663496, Compound 362	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328224&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084557	384583139							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644430	[O-][N+](=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32N6O5/c32-19-22-1-3-23(4-2-22)21-35-15-11-25(12-16-35)34-30(38)24-5-10-29(33-20-24)31(39)36-17-13-28(14-18-36)42-27-8-6-26(7-9-27)37(40)41/h1-10,20,25,28H,11-18,21H2,(H,34,38)	DSEUJSHMFHEHFZ-UHFFFAOYSA-N	328225	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- nitrophenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 363::US9663496, Compound 363	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328225&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710493	384583140							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644431	Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O3/c32-19-22-1-3-23(4-2-22)21-36-15-11-26(12-16-36)35-30(38)24-5-10-29(34-20-24)31(39)37-17-13-28(14-18-37)40-27-8-6-25(33)7-9-27/h1-10,20,26,28H,11-18,21,33H2,(H,35,38)	IJVKVAYSNCCZQF-UHFFFAOYSA-N	328226	6-(4-(4-aminophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 364::US9663496, Compound 364	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328226&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710347	384583141							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644432	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)N1CCCC1	InChI=1S/C35H40N6O3/c36-23-26-3-5-27(6-4-26)25-39-19-13-29(14-20-39)38-34(42)33-12-7-28(24-37-33)35(43)41-21-15-32(16-22-41)44-31-10-8-30(9-11-31)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)	XBCVAHYGHVSLMP-UHFFFAOYSA-N	328227	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)picolinamide::US9663496, Compound 365	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328227&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486209	384583142							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644433	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H36N6O4/c1-23(40)36-27-7-9-29(10-8-27)43-30-14-18-39(19-15-30)33(42)31-11-6-26(21-35-31)32(41)37-28-12-16-38(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)(H,37,41)	GNMBIYXIFWVHBU-UHFFFAOYSA-N	328228	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 366::US9663496, Compound 366	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328228&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710449	384583143							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644434	CS(=O)(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O5S/c1-44(41,42)36-27-7-9-28(10-8-27)43-29-14-18-38(19-15-29)32(40)30-11-6-25(21-34-30)31(39)35-26-12-16-37(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29,36H,12-19,22H2,1H3,(H,35,39)	GJMRQEGEEYASHD-UHFFFAOYSA-N	328229	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (methylsulfonamido)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 367::US9663496, Compound 367	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328229&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710731	384583144							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644435	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCCC3)cn2)cc1	InChI=1S/C34H32FN5O4/c35-26-6-11-29(12-7-26)44-31-14-8-27(22-37-31)38-33(42)30-13-5-25(21-36-30)34(43)40-19-15-24(16-20-40)32(41)23-3-9-28(10-4-23)39-17-1-2-18-39/h3-14,21-22,24H,1-2,15-20H2,(H,38,42)	STPZXMKMNKFXAI-UHFFFAOYSA-N	328230	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 368::US9663496, Compound 368	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328230&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710458	384583145							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644436	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C#N	InChI=1S/C33H32N6O3/c34-19-23-1-3-25(4-2-23)22-38-15-13-29(14-16-38)37-32(41)30-10-9-28(21-36-30)33(42)39-17-11-27(12-18-39)31(40)26-7-5-24(20-35)6-8-26/h1-10,21,27,29H,11-18,22H2,(H,37,41)	NGDYCJGYGAYDIM-UHFFFAOYSA-N	328231	5-(4-(4-cyanobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 369::US9663496, Compound 369	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328231&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710591	384583146							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644437	CN(C)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H38N6O3/c1-37(2)28-8-10-29(11-9-28)42-30-15-19-39(20-16-30)33(41)31-12-7-26(22-35-31)32(40)36-27-13-17-38(18-14-27)23-25-5-3-24(21-34)4-6-25/h3-12,22,27,30H,13-20,23H2,1-2H3,(H,36,40)	FDFZOJXJKCBWID-UHFFFAOYSA-N	328232	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (dimethylamino)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 370	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328232&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710577	384583147							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644438	O=C(CCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C51H67N9O10S/c52-32-36-4-6-37(7-5-36)34-59-20-14-40(15-21-59)56-49(63)38-8-13-43(54-33-38)50(64)60-22-16-42(17-23-60)70-41-11-9-39(10-12-41)55-47(62)18-24-66-26-28-68-30-31-69-29-27-67-25-19-53-46(61)3-1-2-45-48-44(35-71-45)57-51(65)58-48/h4-13,33,40,42,44-45,48H,1-3,14-31,34-35H2,(H,53,61)(H,55,62)(H,56,63)(H2,57,58,65)/t44-,45-,48-/m0/s1	FDMHQQSOTGDXCF-UMQMWPJCSA-N	328233	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(17-oxo-20- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10,13-tetraoxa- 16- azaicosanamido)phenoxy )piperidine-1- carbonyl)nicotinamide::US10377742, Compound 371::US9663496, Compound 371	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328233&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119947	384583148							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644439	CSc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O3S/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	FCLDRVKLOOYCDQ-UHFFFAOYSA-N	328234	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylthio)benzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 372::US9663496, Compound 372	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328234&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710721	384583149							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644440	CSc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)[N+]([O-])=O)CC1	InChI=1S/C32H35N5O5S/c1-43-28-9-4-23(5-10-28)30(38)24-12-18-36(19-13-24)32(40)29-11-6-25(20-33-29)31(39)34-26-14-16-35(17-15-26)21-22-2-7-27(8-3-22)37(41)42/h2-11,20,24,26H,12-19,21H2,1H3,(H,34,39)	ZDKXCRDPYIEKMR-UHFFFAOYSA-N	328235	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4- nitrobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 373::US9663496, Compound 373	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328235&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486211	384583150							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644441	CS(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CC[N+]([O-])(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O5S/c1-44(43)29-9-6-25(7-10-29)31(39)26-12-16-37(17-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-18-38(42,19-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	VJTBJPIFAJIXLV-UHFFFAOYSA-N	328236	1-(4-cyanobenzyl)-4-(5- (4-(4- (methylsulfinyl)benzoyl)  piperidine-1- carbonyl)picolinamido)  piperidine 1-oxide::US9663496, Compound 374	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328236&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119890	384583151							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644442	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)-n1cccn1	InChI=1S/C35H35N7O3/c36-22-25-2-4-26(5-3-25)24-40-18-14-30(15-19-40)39-34(44)32-11-8-29(23-37-32)35(45)41-20-12-28(13-21-41)33(43)27-6-9-31(10-7-27)42-17-1-16-38-42/h1-11,16-17,23,28,30H,12-15,18-21,24H2,(H,39,44)	CYNGANONKKUHAT-UHFFFAOYSA-N	328237	5-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 375::US9663496, Compound 375	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328237&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710742	384583152							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644443	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCOCC1	InChI=1S/C36H40N6O4/c37-23-26-1-3-27(4-2-26)25-40-15-13-31(14-16-40)39-35(44)33-10-7-30(24-38-33)36(45)42-17-11-29(12-18-42)34(43)28-5-8-32(9-6-28)41-19-21-46-22-20-41/h1-10,24,29,31H,11-22,25H2,(H,39,44)	WCBBIBOXLBNHOV-UHFFFAOYSA-N	328238	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- morpholinobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 376::US9663496, Compound 376	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328238&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710482	384583153							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644444	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C36H40N6O3/c37-23-26-3-5-27(6-4-26)25-40-19-15-31(16-20-40)39-35(44)30-9-12-33(38-24-30)36(45)42-21-13-29(14-22-42)34(43)28-7-10-32(11-8-28)41-17-1-2-18-41/h3-12,24,29,31H,1-2,13-22,25H2,(H,39,44)	JHDUODWCMKEUJW-UHFFFAOYSA-N	328239	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 377::US9663496, Compound 377	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328239&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710745	384583154							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644445	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(c1)[N+]([O-])=O	InChI=1S/C32H34N6O6/c1-43-27-7-9-30(29(18-27)38(41)42)44-26-12-16-37(17-13-26)32(40)28-8-6-24(20-34-28)31(39)35-25-10-14-36(15-11-25)21-23-4-2-22(19-33)3-5-23/h2-9,18,20,25-26H,10-17,21H2,1H3,(H,35,39)	PNQUXRANYGABJB-UHFFFAOYSA-N	328240	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-methoxy-2- nitrophenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 378::US9663496, Compound 378	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328240&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710644	384583155							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644446	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCOCC3)cn2)cc1	InChI=1S/C34H32FN5O5/c35-26-4-9-29(10-5-26)45-31-12-6-27(22-37-31)38-33(42)30-11-3-25(21-36-30)34(43)40-15-13-24(14-16-40)32(41)23-1-7-28(8-2-23)39-17-19-44-20-18-39/h1-12,21-22,24H,13-20H2,(H,38,42)	GMARCTCAIUDFNX-UHFFFAOYSA-N	328241	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- morpholinobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 379::US9663496, Compound 379	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328241&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710846	384583156							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644447	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C37H43N7O3/c1-41-20-22-43(23-21-41)33-9-6-29(7-10-33)35(45)30-12-18-44(19-13-30)37(47)31-8-11-34(39-25-31)36(46)40-32-14-16-42(17-15-32)26-28-4-2-27(24-38)3-5-28/h2-11,25,30,32H,12-23,26H2,1H3,(H,40,46)	CQUHOAICBBXVEG-UHFFFAOYSA-N	328242	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 380::US9663496, Compound 380	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328242&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710545	384583157							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644448	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C35H40FN5O3/c36-29-8-3-25(4-9-29)24-39-19-15-30(16-20-39)38-34(43)28-7-12-32(37-23-28)35(44)41-21-13-27(14-22-41)33(42)26-5-10-31(11-6-26)40-17-1-2-18-40/h3-12,23,27,30H,1-2,13-22,24H2,(H,38,43)	INGGFDWTZNSBPY-UHFFFAOYSA-N	328243	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 381::US9663496, Compound 381	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328243&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710596	384583158							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644449	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCCC3)cn2)cc1	InChI=1S/C34H32FN5O4/c35-26-6-11-29(12-7-26)44-31-14-8-27(22-37-31)38-33(42)25-5-13-30(36-21-25)34(43)40-19-15-24(16-20-40)32(41)23-3-9-28(10-4-23)39-17-1-2-18-39/h3-14,21-22,24H,1-2,15-20H2,(H,38,42)	AECCUDKFJGLGKU-UHFFFAOYSA-N	328244	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 382::US9663496, Compound 382	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328244&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710400	384583159							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644450	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NC(C)=O)c1	InChI=1S/C34H38N6O5/c1-23(41)37-31-19-29(44-2)8-10-32(31)45-28-13-17-40(18-14-28)34(43)30-9-7-26(21-36-30)33(42)38-27-11-15-39(16-12-27)22-25-5-3-24(20-35)4-6-25/h3-10,19,21,27-28H,11-18,22H2,1-2H3,(H,37,41)(H,38,42)	YZTYOHDMZFCQJX-UHFFFAOYSA-N	328245	6-(4-(2-acetamido-4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 383::US9663496, Compound 383	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328245&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710679	384573172							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644451	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(N)c1	InChI=1S/C32H36N6O4/c1-41-27-7-9-30(28(34)18-27)42-26-12-16-38(17-13-26)32(40)29-8-6-24(20-35-29)31(39)36-25-10-14-37(15-11-25)21-23-4-2-22(19-33)3-5-23/h2-9,18,20,25-26H,10-17,21,34H2,1H3,(H,36,39)	PADKHLIKCSPVGB-UHFFFAOYSA-N	328246	6-(4-(2-amino-4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 384::US9663496, Compound 384	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328246&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710732	384573173							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644452	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(c1)N(C)C	InChI=1S/C34H40N6O4/c1-38(2)31-20-29(43-3)9-11-32(31)44-28-14-18-40(19-15-28)34(42)30-10-8-26(22-36-30)33(41)37-27-12-16-39(17-13-27)23-25-6-4-24(21-35)5-7-25/h4-11,20,22,27-28H,12-19,23H2,1-3H3,(H,37,41)	USKHWBFFPMZFMQ-UHFFFAOYSA-N	328247	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2- (dimethylamino)-4- methoxyphenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 385::US9663496, Compound 385	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328247&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710571	384573174							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644453	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N8O2/c33-19-23-1-5-25(6-2-23)21-39-15-11-27(12-16-39)35-31(41)29-9-10-30(38-37-29)32(42)36-28-13-17-40(18-14-28)22-26-7-3-24(20-34)4-8-26/h1-10,27-28H,11-18,21-22H2,(H,35,41)(H,36,42)	DOZGCVLBIVAPAB-UHFFFAOYSA-N	328248	N3,N6-bis(1-(4- cyanobenzyl)piperidin-4- yl)pyridazine-3,6- dicarboxamide::US10377742, Compound 386::US9663496, Compound 386	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328248&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710695	384573175							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644454	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-27-8-6-24(7-9-27)30(39)25-12-18-38(19-13-25)32(41)29-11-10-28(35-36-29)31(40)34-26-14-16-37(17-15-26)21-23-4-2-22(20-33)3-5-23/h2-11,25-26H,12-19,21H2,1H3,(H,34,40)	ZLENIQODLNSTCZ-UHFFFAOYSA-N	328249	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyridazine-3- carboxamide::US10377742, Compound 387::US9663496, Compound 387	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328249&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710466	384573176							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644455	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C#N	InChI=1S/C32H31N7O3/c33-19-22-1-3-24(4-2-22)21-38-15-13-27(14-16-38)35-31(41)28-9-10-29(37-36-28)32(42)39-17-11-26(12-18-39)30(40)25-7-5-23(20-34)6-8-25/h1-10,26-27H,11-18,21H2,(H,35,41)	QXJZMAPBUWEADI-UHFFFAOYSA-N	328250	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)pyridazine-3- carboxamide::US9663496, Compound 388	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328250&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486212	384573177							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644456	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NS(C)(=O)=O)c1	InChI=1S/C33H38N6O6S/c1-44-28-8-10-31(30(19-28)37-46(2,42)43)45-27-13-17-39(18-14-27)33(41)29-9-7-25(21-35-29)32(40)36-26-11-15-38(16-12-26)22-24-5-3-23(20-34)4-6-24/h3-10,19,21,26-27,37H,11-18,22H2,1-2H3,(H,36,40)	ACUWKTOTLUBMTK-UHFFFAOYSA-N	328251	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-methoxy-2- (methylsulfonamido)  phenoxy)piperidine-1- carbonyl)nicotinamide::US9663496, Compound 389	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328251&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710274	384573178							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644457	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H35N5O4/c1-23(39)26-6-9-29(10-7-26)42-30-14-18-38(19-15-30)33(41)31-11-8-27(21-35-31)32(40)36-28-12-16-37(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)	VPANDGDZYUHJNA-UHFFFAOYSA-N	328252	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 390::US9663496, Compound 390	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328252&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710332	384573179							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644458	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H35FN4O4/c1-22(38)24-4-9-28(10-5-24)41-29-14-18-37(19-15-29)32(40)30-11-6-25(20-34-30)31(39)35-27-12-16-36(17-13-27)21-23-2-7-26(33)8-3-23/h2-11,20,27,29H,12-19,21H2,1H3,(H,35,39)	KSGRCIGWEWONAI-UHFFFAOYSA-N	328253	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 391::US9663496, Compound 391	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328253&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710670	384573180							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644459	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)-n2cccn2)cc1	InChI=1S/C34H35FN6O3/c35-28-7-2-24(3-8-28)23-39-18-14-29(15-19-39)38-33(43)27-6-11-31(36-22-27)34(44)40-20-12-26(13-21-40)32(42)25-4-9-30(10-5-25)41-17-1-16-37-41/h1-11,16-17,22,26,29H,12-15,18-21,23H2,(H,38,43)	BUMYTKZYNNGHLL-UHFFFAOYSA-N	328254	6-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 392::US9663496, Compound 392	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328254&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710817	384573181							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
644460	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)-n1cccn1	InChI=1S/C35H35N7O3/c36-22-25-2-4-26(5-3-25)24-40-18-14-30(15-19-40)39-34(44)29-8-11-32(37-23-29)35(45)41-20-12-28(13-21-41)33(43)27-6-9-31(10-7-27)42-17-1-16-38-42/h1-11,16-17,23,28,30H,12-15,18-21,24H2,(H,39,44)	RUVMWHOZYSQUPX-UHFFFAOYSA-N	328255	6-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 393::US9663496, Compound 393	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q26975P8		aid1796804	US9663496	Irving, M; Shaw, S	Rigel Pharmaceuticals, Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328255&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710667	384573182							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816685	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H33FN6O2/c32-27-8-5-25(6-9-27)22-37-15-17-38(18-16-37)31(40)29-10-7-26(20-34-29)30(39)35-28-11-13-36(14-12-28)21-24-3-1-23(19-33)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,35,39)	OFHFMKWBHZUCBG-UHFFFAOYSA-N	327862	N-(4-(4- cyanobenzyl)piperadin- 4-yl)-6-(4-(4- fluorobenzyl)piperizine- 1-carbonyl)picolinamide::US10377742, Compound 1::US9663496, Compound 1	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327862&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084602	384582778							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816686	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCNCC1	InChI=1S/C24H28N6O2/c25-15-18-1-3-19(4-2-18)17-29-11-7-21(8-12-29)28-23(31)22-6-5-20(16-27-22)24(32)30-13-9-26-10-14-30/h1-6,16,21,26H,7-14,17H2,(H,28,31)	XJFFGYUNDZFZOG-UHFFFAOYSA-N	327863	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(piperazine-1- carbonyl)picolinamide::US10377742, Compound 2::US9663496, Compound 2	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327863&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073382	384582779							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816687	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C29H31F2N5O2/c30-25-6-1-22(2-7-25)20-33-11-15-35(16-12-33)28(37)24-5-10-27(32-19-24)29(38)36-17-13-34(14-18-36)21-23-3-8-26(31)9-4-23/h1-10,19H,11-18,20-21H2	ZCVDBEVZVHBBJC-UHFFFAOYSA-N	327864	US10377742, Compound 3::US9663496, Compound 3::pyridine-2,5-diylbis((4- (4- fluorobenzyl)piperazin- 1-yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327864&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652031	384582780							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816688	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN6O3/c32-26-8-3-23(4-9-26)21-36-15-17-38(18-16-36)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-37(14-12-27)30(40)24-5-1-22(19-33)2-6-24/h1-10,20,27H,11-18,21H2,(H,35,39)	AIJFSOPJUPPZAC-UHFFFAOYSA-N	327865	N-(1-(4- cyanobenzoyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 4::US9663496, Compound 4	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327865&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652032	384582781							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816689	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cccc(Cc2ccccc2)c1	InChI=1S/C33H31N5O2/c34-21-25-9-11-26(12-10-25)23-38-17-15-29(16-18-38)36-33(40)31-14-13-28(22-35-31)32(39)37-30-8-4-7-27(20-30)19-24-5-2-1-3-6-24/h1-14,20,22,29H,15-19,23H2,(H,36,40)(H,37,39)	PJEQHYITGSHAGC-UHFFFAOYSA-N	327866	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(3- benzylphenyl)pyridine- 2,5-dicarboxamide::US10377742, Compound 5::US9663496, Compound 5	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327866&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652033	384582782							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816690	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C30H31FN6O4S/c31-25-6-1-23(2-7-25)21-35-15-17-36(18-16-35)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-37(14-12-26)42(40,41)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)	MJVVGQPISJDCKE-UHFFFAOYSA-N	327867	N-(4-((4- cyanophenyl)sulfonyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 6::US9663496, Compound 6	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327867&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073245	384582783							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816691	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)C2CCCCC2)cc1	InChI=1S/C30H38FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h6-11,20,23,26H,1-5,12-19,21H2,(H,33,37)	KUYAVZMMGBODBA-UHFFFAOYSA-N	327868	N-(1- (cyclohexanecarbonyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 7::US9663496, Compound 7	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327868&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652371	384582784							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816692	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccccc2)cc1	InChI=1S/C30H32FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h1-11,20,26H,12-19,21H2,(H,33,37)	PGYYJEYPHRIKEA-UHFFFAOYSA-N	327869	N-(1-(benzoyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 8::US9663496, Compound 8	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327869&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652372	384582785							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816693	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccn(Cc3ccc(cc3)C#N)n2)cc1	InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)19-35-13-15-36(16-14-35)29(39)24-7-10-26(32-18-24)28(38)33-27-11-12-37(34-27)20-23-3-1-21(17-31)2-4-23/h1-12,18H,13-16,19-20H2,(H,33,34,38)	RJDFHCCYYFFSBE-UHFFFAOYSA-N	327870	N-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 9::US9663496, Compound 9	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327870&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073277	384582786							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816694	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Cc3ccccc3)cc2)cc1	InChI=1S/C31H29FN4O2/c32-27-11-6-25(7-12-27)22-35-16-18-36(19-17-35)31(38)26-10-15-29(33-21-26)30(37)34-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,34,37)	VRFSYYBIXZHSAS-UHFFFAOYSA-N	327871	N-(4-benzylphenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 10::US9663496, Compound 10	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327871&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073517	384582787							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816695	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-26-11-6-22(7-12-26)21-34-16-18-35(19-17-34)30(37)25-10-15-28(32-20-25)29(36)33-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,33,36)	PRJISZJJPGFGHG-UHFFFAOYSA-N	327872	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(4- phenylphenyl)  picolinamide::US10377742, Compound 11::US9663496, Compound 11	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327872&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073329	384582788							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816696	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(c2)-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-26-12-9-22(10-13-26)21-34-15-17-35(18-16-34)30(37)25-11-14-28(32-20-25)29(36)33-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,33,36)	DEAYGZRRXFNGTA-UHFFFAOYSA-N	327873	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(3- phenylphenyl)  picolinamide::US10377742, Compound 12::US9663496, Compound 12	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327873&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073201	384582789							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816697	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC3CCCCC3)CC2)cc1	InChI=1S/C30H40FN5O2/c31-26-9-6-24(7-10-26)22-35-16-18-36(19-17-35)30(38)25-8-11-28(32-20-25)29(37)33-27-12-14-34(15-13-27)21-23-4-2-1-3-5-23/h6-11,20,23,27H,1-5,12-19,21-22H2,(H,33,37)	KCGHFTHUSALUFF-UHFFFAOYSA-N	327874	N-(1-(cyclohexylmethyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 13::US9663496, Compound 13	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327874&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073564	384582790							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816698	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)c2ccccc2)cc1	InChI=1S/C29H32FN5O2/c30-24-9-6-22(7-10-24)21-33-16-18-35(19-17-33)29(37)23-8-11-27(31-20-23)28(36)32-25-12-14-34(15-13-25)26-4-2-1-3-5-26/h1-11,20,25H,12-19,21H2,(H,32,36)	HQTGOKGRHCNFPD-UHFFFAOYSA-N	327875	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1- (phenyl)piperidin-4- yl)picolinamide::US10377742, Compound 14::US9663496, Compound 14	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327875&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652373	384582791							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816699	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCC3(CCN(Cc4ccc(cc4)C#N)C3)CC2)cc1	InChI=1S/C34H37FN6O2/c35-30-8-5-28(6-9-30)23-38-17-19-41(20-18-38)32(42)29-7-10-31(37-22-29)33(43)40-15-12-34(13-16-40)11-14-39(25-34)24-27-3-1-26(21-36)2-4-27/h1-10,22H,11-20,23-25H2	GUOFMHPMAHVMLC-UHFFFAOYSA-N	327876	4-((8-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinoyl)- 2,8- diazaspiro[4.5]decan-2- yl)methyl)benzonitrile::US10377742, Compound 15::US9663496, Compound 15	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327876&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652374	384582792							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816700	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc1	InChI=1S/C30H27FN4O3/c31-24-9-6-22(7-10-24)21-34-16-18-35(19-17-34)30(37)23-8-15-28(32-20-23)29(36)33-25-11-13-27(14-12-25)38-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,33,36)	KFWUZHLIUCMOPR-UHFFFAOYSA-N	327877	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- phenoxyphenyl)  picolinamide::US10377742, Compound 16::US9663496, Compound 16	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327877&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652375	384582793							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816701	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(OCc3ccccc3)cc2)cc1	InChI=1S/C30H28FN3O2/c31-27-11-6-23(7-12-27)21-33-16-18-34(19-17-33)30(35)26-10-15-29(32-20-26)25-8-13-28(14-9-25)36-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2	LFRKRHVIDSBBJO-UHFFFAOYSA-N	327878	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- (benzyloxy)phenyl)  pyridin-3-yl)methanone::US10377742, Compound 17::US9663496, Compound 17	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327878&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652712	384582794							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816702	CC(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1	InChI=1S/C31H36FN5O2/c1-23(25-5-3-2-4-6-25)36-15-13-28(14-16-36)34-30(38)29-12-9-26(21-33-29)31(39)37-19-17-35(18-20-37)22-24-7-10-27(32)11-8-24/h2-12,21,23,28H,13-20,22H2,1H3,(H,34,38)	OTTMHRBJZANTRA-UHFFFAOYSA-N	327879	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(1- phenylethyl)piperidin-4- yl)picolinamide::US10377742, Compound 18::US9663496, Compound 18	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327879&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652713	384582795							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816703	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2-c2ccccc2)cc1	InChI=1S/C30H27FN4O2/c31-25-13-10-22(11-14-25)21-34-16-18-35(19-17-34)30(37)24-12-15-28(32-20-24)29(36)33-27-9-5-4-8-26(27)23-6-2-1-3-7-23/h1-15,20H,16-19,21H2,(H,33,36)	DKZIWVLUHXKRHI-UHFFFAOYSA-N	327880	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(2- phenylphenyl)  picolinamide::US10377742, Compound 19::US9663496, Compound 19	5'-AMP-activated protein kinase catalytic subunit alpha-2					>1000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327880&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652714	384582796							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816704	[O-][N+](=O)c1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C30H26FN5O4/c31-25-8-1-21(2-9-25)20-34-15-17-35(18-16-34)30(38)24-7-14-28(32-19-24)29(37)33-26-10-3-22(4-11-26)23-5-12-27(13-6-23)36(39)40/h1-14,19H,15-18,20H2,(H,33,37)	GAYRGESOQUQOTJ-UHFFFAOYSA-N	327881	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- nitrophenyl)phenyl)  picolinamide::US10377742, Compound 20::US9663496, Compound 20	5'-AMP-activated protein kinase catalytic subunit alpha-2					>1000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327881&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652715	384582797							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816705	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(Oc3ccccc3)c2)cc1	InChI=1S/C30H27FN4O3/c31-24-12-9-22(10-13-24)21-34-15-17-35(18-16-34)30(37)23-11-14-28(32-20-23)29(36)33-25-5-4-8-27(19-25)38-26-6-2-1-3-7-26/h1-14,19-20H,15-18,21H2,(H,33,36)	CQQMMXMEYNOOTM-UHFFFAOYSA-N	327882	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(3- phenoxyphenyl)  picolinamide::US10377742, Compound 21::US9663496, Compound 21	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327882&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652716	384582798							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816706	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1	InChI=1S/C30H28FN3O2/c31-27-12-9-23(10-13-27)21-33-15-17-34(18-16-33)30(35)26-11-14-29(32-20-26)25-7-4-8-28(19-25)36-22-24-5-2-1-3-6-24/h1-14,19-20H,15-18,21-22H2	QSFRHVLXMAFXQR-UHFFFAOYSA-N	327883	(6-(3- (benzyloxy)phenyl)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 22::US9663496, Compound 22	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327883&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653045	384582799							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816707	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cnn(Cc3ccc(cc3)C#N)c2)cc1	InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)18-35-11-13-36(14-12-35)29(39)24-7-10-27(32-16-24)28(38)34-26-17-33-37(20-26)19-23-3-1-21(15-31)2-4-23/h1-10,16-17,20H,11-14,18-19H2,(H,34,38)	NFOUIFJMANKDPS-UHFFFAOYSA-N	327884	N-(1-(4-cyanobenzyl)- 1H-pyrazol-4-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 23::US9663496, Compound 23	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327884&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653046	384582800							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816708	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C#N)cc1	InChI=1S/C31H26FN5O2/c32-27-10-3-23(4-11-27)21-36-15-17-37(18-16-36)31(39)26-9-14-29(34-20-26)30(38)35-28-12-7-25(8-13-28)24-5-1-22(19-33)2-6-24/h1-14,20H,15-18,21H2,(H,35,38)	XSUMTXIVYVXHQF-UHFFFAOYSA-N	327885	N-(4-(4- cyanophenyl)phenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 24::US9663496, Compound 24	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327885&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653047	384582801							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816709	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C31H26F4N4O2/c32-26-10-1-21(2-11-26)20-38-15-17-39(18-16-38)30(41)24-7-14-28(36-19-24)29(40)37-27-12-5-23(6-13-27)22-3-8-25(9-4-22)31(33,34)35/h1-14,19H,15-18,20H2,(H,37,40)	RBSXAXHVCUKMIZ-UHFFFAOYSA-N	327886	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- trifluoromethylphenyl)  phenyl)picolinamide::US10377742, Compound 25::US9663496, Compound 25	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327886&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653048	384582802							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816710	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)C(=O)c2ccccc2)cc1	InChI=1S/C31H27FN4O3/c32-26-11-6-22(7-12-26)21-35-16-18-36(19-17-35)31(39)25-10-15-28(33-20-25)30(38)34-27-13-8-24(9-14-27)29(37)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,34,38)	IVEYKDVYNMMLFY-UHFFFAOYSA-N	327887	N-(4-benzoylphenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 26::US9663496, Compound 26	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327887&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653049	384582803							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816711	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(OCc3ccccc3)cc2)cc1	InChI=1S/C31H29FN4O3/c32-26-9-6-23(7-10-26)21-35-16-18-36(19-17-35)31(38)25-8-15-29(33-20-25)30(37)34-27-11-13-28(14-12-27)39-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2,(H,34,37)	IKKVPXFGSRKNJV-UHFFFAOYSA-N	327888	N-(4-benzyloxyphenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 27::US9663496, Compound 27	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327888&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653409	384582804							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816712	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Br)cc2)cc1	InChI=1S/C24H22BrFN4O2/c25-19-4-8-21(9-5-19)28-23(31)22-10-3-18(15-27-22)24(32)30-13-11-29(12-14-30)16-17-1-6-20(26)7-2-17/h1-10,15H,11-14,16H2,(H,28,31)	MTYUQDCNXVHHAR-UHFFFAOYSA-N	327889	N-(4-bromophenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 28::US9663496, Compound 28	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327889&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653410	384582805							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816713	COc1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H29FN4O3/c1-39-28-13-6-24(7-14-28)23-4-11-27(12-5-23)34-30(37)29-15-8-25(20-33-29)31(38)36-18-16-35(17-19-36)21-22-2-9-26(32)10-3-22/h2-15,20H,16-19,21H2,1H3,(H,34,37)	DVMILXSBZSNOPF-UHFFFAOYSA-N	327890	N-(4-(4- methoxyphenyl)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 29::US9663496, Compound 29	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327890&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653411	384582806							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816714	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Cc4ccccc4)cc3)nc2)cc1	InChI=1S/C30H29FN4O/c31-27-11-6-25(7-12-27)22-34-16-18-35(19-17-34)30(36)26-10-15-29(32-21-26)33-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,32,33)	PXCXFGLKFBBGMD-UHFFFAOYSA-N	327891	(6-(4- benzylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 30::US9663496, Compound 30	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327891&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653412	384582807							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816715	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC3CN(Cc4ccc(cc4)C#N)CCC23)cc1	InChI=1S/C32H35FN6O/c33-29-8-5-26(6-9-29)21-36-15-17-38(18-16-36)32(40)27-7-10-31(35-20-27)39-14-11-28-23-37(13-12-30(28)39)22-25-3-1-24(19-34)2-4-25/h1-10,20,28,30H,11-18,21-23H2	NQUWUUOUBGGZER-UHFFFAOYSA-N	409010	4-((2-(5-(4-(4-fluorobenzyl)piperazine-1- carbonyl)pyridin-2-yl)-2,8- diazaspiro[4.5]decan-8- yl)methyl)benzonitrile::US10377742, Compound 31	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409010&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134295428	406799638							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816716	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccc(c2)C#N)cc1	InChI=1S/C31H26FN5O2/c32-27-9-4-22(5-10-27)21-36-14-16-37(17-15-36)31(39)26-8-13-29(34-20-26)30(38)35-28-11-6-24(7-12-28)25-3-1-2-23(18-25)19-33/h1-13,18,20H,14-17,21H2,(H,35,38)	GVARIDOMGKXGSD-UHFFFAOYSA-N	327893	N-(4-(3- cyanophenyl)phenyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 32::US9663496, Compound 32	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327893&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653758	384582809							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816717	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3cccc(c3)-c3ccccc3)nc2)cc1	InChI=1S/C29H27FN4O/c30-26-12-9-22(10-13-26)21-33-15-17-34(18-16-33)29(35)25-11-14-28(31-20-25)32-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,31,32)	SZJATISBSPFCJL-UHFFFAOYSA-N	327894	(6-(3- phenylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 33::US9663496, Compound 33	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327894&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653759	384582810							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816718	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1	InChI=1S/C29H27FN4O2/c30-24-9-6-22(7-10-24)21-33-16-18-34(19-17-33)29(35)23-8-15-28(31-20-23)32-25-11-13-27(14-12-25)36-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,31,32)	SCZKOAZZRCYNFT-UHFFFAOYSA-N	327895	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxyphenylamino)  pyridin-3-yl)methanone::US10377742, Compound 34::US9663496, Compound 34	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327895&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653760	384582811							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816719	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(cc2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C32H28FN5O2/c33-29-12-5-25(6-13-29)22-37-15-17-38(18-16-37)32(40)28-11-14-30(35-21-28)26-7-9-27(10-8-26)31(39)36-20-24-3-1-23(19-34)2-4-24/h1-14,21H,15-18,20,22H2,(H,36,39)	PTFCCBDWBUWRTB-UHFFFAOYSA-N	327896	(6-(4-(4- cyanobenzylcarbamoyl)  phenyl)pyridin-3-yl)(4- (4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 35::US9663496, Compound 35	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327896&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653761	384582812							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816720	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1	InChI=1S/C30H33FN6O/c31-27-8-5-25(6-9-27)22-36-15-17-37(18-16-36)30(38)26-7-10-29(33-20-26)34-28-11-13-35(14-12-28)21-24-3-1-23(19-32)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,33,34)	AUSCOAAXXZHOLH-UHFFFAOYSA-N	327897	(6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3- yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 36::US9663496, Compound 36	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327897&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084728	384582813							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816721	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(cc3)-c3ccccc3)nc2)cc1	InChI=1S/C29H27FN4O/c30-26-11-6-22(7-12-26)21-33-16-18-34(19-17-33)29(35)25-10-15-28(31-20-25)32-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,31,32)	IDNTUUFQESKWJF-UHFFFAOYSA-N	327898	(6-(4- phenylphenylamino)  pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 37::US9663496, Compound 37	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327898&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56653762	384582814							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816722	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1	InChI=1S/C31H28N8O2/c32-17-22-1-5-24(6-2-22)20-38-14-11-27(12-15-38)35-31(41)28-10-9-26(19-34-28)30(40)36-29-13-16-39(37-29)21-25-7-3-23(18-33)4-8-25/h1-10,13,16,19,27H,11-12,14-15,20-21H2,(H,35,41)(H,36,37,40)	OWORLXKPKKUEKB-UHFFFAOYSA-N	327899	N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4- cyanobenzyl)piperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 38::US9663496, Compound 38	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327899&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654098	384582815							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816723	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cc[nH]c2)cc1	InChI=1S/C28H26FN5O2/c29-24-6-1-20(2-7-24)19-33-13-15-34(16-14-33)28(36)23-5-10-26(31-18-23)27(35)32-25-8-3-21(4-9-25)22-11-12-30-17-22/h1-12,17-18,30H,13-16,19H2,(H,32,35)	ANLDAUPWGMIDKB-UHFFFAOYSA-N	327900	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(1H- pyrrol-3- yl)phenyl)picolinamide::US10377742, Compound 39::US9663496, Compound 39	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327900&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654099	384582816							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816724	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)N2CCOCC2)cc1	InChI=1S/C28H30FN5O3/c29-23-4-1-21(2-5-23)20-32-11-13-34(14-12-32)28(36)22-3-10-26(30-19-22)27(35)31-24-6-8-25(9-7-24)33-15-17-37-18-16-33/h1-10,19H,11-18,20H2,(H,31,35)	VHXPMMSGAZXAOF-UHFFFAOYSA-N	327901	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- morpholinophenyl)  picolinamide::US10377742, Compound 40::US9663496, Compound 40	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327901&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654100	384582817							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816725	CN1CCN(CC1)c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C29H33FN6O2/c1-33-12-16-35(17-13-33)26-9-7-25(8-10-26)32-28(37)27-11-4-23(20-31-27)29(38)36-18-14-34(15-19-36)21-22-2-5-24(30)6-3-22/h2-11,20H,12-19,21H2,1H3,(H,32,37)	QSOJIZDCHOEGLA-UHFFFAOYSA-N	327902	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methylpiperazin-1- yl)phenyl)picolinamide::US10377742, Compound 41::US9663496, Compound 41	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327902&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654101	384582818							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816726	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(c2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C32H28FN5O2/c33-29-11-8-25(9-12-29)22-37-14-16-38(17-15-37)32(40)28-10-13-30(35-21-28)26-2-1-3-27(18-26)31(39)36-20-24-6-4-23(19-34)5-7-24/h1-13,18,21H,14-17,20,22H2,(H,36,39)	IGRUICVFLYEORO-UHFFFAOYSA-N	327904	(6-(3-(4- cyanobenzylcarbamoyl)  phenyl)pyridin-3yl)(4- (4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 42::US9663496, Compound 42	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327904&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654102	384582820							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816727	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cnn(Cc2ccc(cc2)C#N)c1	InChI=1S/C31H28N8O2/c32-15-22-1-5-24(6-2-22)19-38-13-11-27(12-14-38)36-31(41)29-10-9-26(17-34-29)30(40)37-28-18-35-39(21-28)20-25-7-3-23(16-33)4-8-25/h1-10,17-18,21,27H,11-14,19-20H2,(H,36,41)(H,37,40)	YHEKUCFWUXSDKM-UHFFFAOYSA-N	327905	N5-(1-(4-cyanobenzyl)- 1H-pyrazol-4-yl)-N2-(1- (4- cyanobenzyl)piperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 43::US9663496, Compound 43	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327905&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654434	384582821							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816728	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)C(=O)NCc2ccc(cc2)C#N)cc1	InChI=1S/C33H29FN6O3/c34-28-10-5-25(6-11-28)22-39-15-17-40(18-16-39)33(43)27-9-14-30(36-21-27)32(42)38-29-12-7-26(8-13-29)31(41)37-20-24-3-1-23(19-35)2-4-24/h1-14,21H,15-18,20,22H2,(H,37,41)(H,38,42)	BPUSTKQLALECFR-UHFFFAOYSA-N	327906	N-(4-(4- cyanobenzylcarbamoyl)  phenyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 47::US9663496, Compound 47	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327906&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654437	384582822							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816729	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(cc3)C(=O)NCc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C32H29FN6O2/c33-28-10-5-25(6-11-28)22-38-15-17-39(18-16-38)32(41)27-9-14-30(35-21-27)37-29-12-7-26(8-13-29)31(40)36-20-24-3-1-23(19-34)2-4-24/h1-14,21H,15-18,20,22H2,(H,35,37)(H,36,40)	LTAMCBAUTUHECW-UHFFFAOYSA-N	327907	(6-(4-(4- cyanobenzylcarbamoyl)  phenylamino)pyridin-3- yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone::US10377742, Compound 48::US9663496, Compound 48	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327907&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654438	384582823							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816730	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C30H32F3N5O2/c31-24-4-1-21(2-5-24)19-37-11-13-38(14-12-37)30(40)23-3-6-28(34-18-23)29(39)35-27-7-9-36(10-8-27)20-22-15-25(32)17-26(33)16-22/h1-6,15-18,27H,7-14,19-20H2,(H,35,39)	JEBWTTQATIZHGU-UHFFFAOYSA-N	327908	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 49::US9663496, Compound 49	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327908&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654780	384582824							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816731	Cc1cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)ccc1F	InChI=1S/C31H35F2N5O2/c1-22-18-24(4-8-28(22)33)21-36-12-10-27(11-13-36)35-30(39)29-9-5-25(19-34-29)31(40)38-16-14-37(15-17-38)20-23-2-6-26(32)7-3-23/h2-9,18-19,27H,10-17,20-21H2,1H3,(H,35,39)	MYKBCPMYGPOKII-UHFFFAOYSA-N	327909	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluoro-3- methylbenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 50::US9663496, Compound 50	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327909&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654781	384582825							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816732	COc1ccc(CC2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H37FN4O3/c1-40-29-13-6-24(7-14-29)20-23-4-11-28(12-5-23)35-31(38)30-15-8-26(21-34-30)32(39)37-18-16-36(17-19-37)22-25-2-9-27(33)10-3-25/h2-3,6-10,13-15,21,23,28H,4-5,11-12,16-20,22H2,1H3,(H,35,38)	JINWVOWDQOOBDT-UHFFFAOYSA-N	327910	N-(1-(4- chlorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 51::US9663496, Compound 51	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327910&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073262	384582826							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816733	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(Cl)cc3)CC2)cc1	InChI=1S/C30H33ClFN5O2/c31-25-6-1-22(2-7-25)20-35-13-11-27(12-14-35)34-29(38)28-10-5-24(19-33-28)30(39)37-17-15-36(16-18-37)21-23-3-8-26(32)9-4-23/h1-10,19,27H,11-18,20-21H2,(H,34,38)	BORCORLFDUVXFQ-UHFFFAOYSA-N	327911	N-(1-(4- chlorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 52::US9663496, Compound 52	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327911&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654782	384582827							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816734	Cc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)cc1	InChI=1S/C31H29FN4O3/c1-22-2-11-27(12-3-22)39-28-13-9-26(10-14-28)34-30(37)29-15-6-24(20-33-29)31(38)36-18-16-35(17-19-36)21-23-4-7-25(32)8-5-23/h2-15,20H,16-19,21H2,1H3,(H,34,37)	RMWNMWQMKJQMNP-UHFFFAOYSA-N	327912	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methylphenoxy)phenyl)  picolinamide::US10377742, Compound 53::US9663496, Compound 53	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327912&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654783	384582828							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816735	COc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)cc1	InChI=1S/C31H29FN4O4/c1-39-26-11-13-28(14-12-26)40-27-9-7-25(8-10-27)34-30(37)29-15-4-23(20-33-29)31(38)36-18-16-35(17-19-36)21-22-2-5-24(32)6-3-22/h2-15,20H,16-19,21H2,1H3,(H,34,37)	RDGQWELXIWGGAA-UHFFFAOYSA-N	327913	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- methoxyphenoxy)  phenyl)picolinamide::US10377742, Compound 54::US9663496, Compound 54	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327913&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56654784	384582829							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816736	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(F)c3)cc2)cc1	InChI=1S/C30H26F2N4O3/c31-23-7-4-21(5-8-23)20-35-14-16-36(17-15-35)30(38)22-6-13-28(33-19-22)29(37)34-25-9-11-26(12-10-25)39-27-3-1-2-24(32)18-27/h1-13,18-19H,14-17,20H2,(H,34,37)	AFHGWQBLKGCROK-UHFFFAOYSA-N	327914	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- fluorophenoxy)phenyl)  picolinamide::US10377742, Compound 55::US9663496, Compound 55	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327914&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655128	384582830							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816737	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(c3)C#N)cc2)cc1	InChI=1S/C31H26FN5O3/c32-25-7-4-22(5-8-25)21-36-14-16-37(17-15-36)31(39)24-6-13-29(34-20-24)30(38)35-26-9-11-27(12-10-26)40-28-3-1-2-23(18-28)19-33/h1-13,18,20H,14-17,21H2,(H,35,38)	ZGVPWOWZROQALT-UHFFFAOYSA-N	327915	N-(4-(3- cyanophenoxy)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 56::US9663496, Compound 56	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327915&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655129	384582831							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816738	COc1cccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)c1	InChI=1S/C31H29FN4O4/c1-39-27-3-2-4-28(19-27)40-26-12-10-25(11-13-26)34-30(37)29-14-7-23(20-33-29)31(38)36-17-15-35(16-18-36)21-22-5-8-24(32)9-6-22/h2-14,19-20H,15-18,21H2,1H3,(H,34,37)	WDGGQCRMJXHVAD-UHFFFAOYSA-N	327916	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- methoxyphenoxy)  phenyl)picolinamide::US10377742, Compound 57::US9663496, Compound 57	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327916&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655130	384582832							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816739	Cc1cccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cc2)c1	InChI=1S/C31H29FN4O3/c1-22-3-2-4-28(19-22)39-27-12-10-26(11-13-27)34-30(37)29-14-7-24(20-33-29)31(38)36-17-15-35(16-18-36)21-23-5-8-25(32)9-6-23/h2-14,19-20H,15-18,21H2,1H3,(H,34,37)	CBGKMLBDMVQWBH-UHFFFAOYSA-N	327917	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(3- methylphenoxy)phenyl)  picolinamide::US10377742, Compound 58::US9663496, Compound 58	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327917&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655131	384582833							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816740	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)cc2)cc1	InChI=1S/C31H26FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)24-5-14-29(34-20-24)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-14,20H,15-18,21H2,(H,35,38)	RANWOMLEXKWTRY-UHFFFAOYSA-N	327918	N-(4-(4- cyanophenoxy)phenyl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 59::US9663496, Compound 59	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327918&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56655132	384582834							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816741	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)cc2)cc1	InChI=1S/C30H26F2N4O3/c31-23-4-1-21(2-5-23)20-35-15-17-36(18-16-35)30(38)22-3-14-28(33-19-22)29(37)34-25-8-12-27(13-9-25)39-26-10-6-24(32)7-11-26/h1-14,19H,15-18,20H2,(H,34,37)	NOIUJGNQSASNRI-UHFFFAOYSA-N	327919	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4-(4- fluorophenoxy)phenyl)  picolinamide::US10377742, Compound 60::US9663496, Compound 60	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327919&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649997	384582835							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816742	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccnc2)cc1	InChI=1S/C29H26FN5O2/c30-25-8-3-21(4-9-25)20-34-14-16-35(17-15-34)29(37)24-7-12-27(32-19-24)28(36)33-26-10-5-22(6-11-26)23-2-1-13-31-18-23/h1-13,18-19H,14-17,20H2,(H,33,36)	JYDMJWGORFCYPJ-UHFFFAOYSA-N	327920	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- (pyridine-3- yl)phenyl)picolinamide::US10377742, Compound 61::US9663496, Compound 61	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327920&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649998	384582836							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816743	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccsc2)cc1	InChI=1S/C28H25FN4O2S/c29-24-6-1-20(2-7-24)18-32-12-14-33(15-13-32)28(35)22-5-10-26(30-17-22)27(34)31-25-8-3-21(4-9-25)23-11-16-36-19-23/h1-11,16-17,19H,12-15,18H2,(H,31,34)	BJRZKIVEUFLPAU-UHFFFAOYSA-N	327921	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4- (thiophen-3- yl)phenyl)picolinamide::US10377742, Compound 62::US9663496, Compound 62	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327921&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56649999	384582837							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816744	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-6-1-22(2-7-24)20-36-13-15-37(16-14-36)30(39)23-5-11-27(33-18-23)29(38)35-25-8-12-28(34-19-25)40-26-9-3-21(17-32)4-10-26/h1-12,18-19H,13-16,20H2,(H,35,38)	SXCVHBDVDRBZIC-UHFFFAOYSA-N	327922	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-(6-(4- cyanophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 63::US9663496, Compound 63	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327922&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650000	384582838							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816745	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3cccc(c3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-7-4-21(5-8-24)20-36-12-14-37(15-13-36)30(39)23-6-10-27(33-18-23)29(38)35-25-9-11-28(34-19-25)40-26-3-1-2-22(16-26)17-32/h1-11,16,18-19H,12-15,20H2,(H,35,38)	ASBBFNPPGCMMTH-UHFFFAOYSA-N	327923	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-(6-(3- cyanophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 64::US9663496, Compound 64	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327923&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650001	384582839							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816746	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-22-4-1-20(2-5-22)19-35-13-15-36(16-14-35)29(38)21-3-11-26(32-17-21)28(37)34-24-8-12-27(33-18-24)39-25-9-6-23(31)7-10-25/h1-12,17-18H,13-16,19H2,(H,34,37)	XOCNQFFZQFEWHW-UHFFFAOYSA-N	327924	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 65::US9663496, Compound 65	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327924&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650324	384582840							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816747	COc1cc(ccc1OC1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C#N	InChI=1S/C33H34N6O4/c1-42-31-18-25(20-35)6-9-30(31)43-28-12-16-39(17-13-28)33(41)26-7-8-29(36-21-26)32(40)37-27-10-14-38(15-11-27)22-24-4-2-23(19-34)3-5-24/h2-9,18,21,27-28H,10-17,22H2,1H3,(H,37,40)	KKQGVOSIFWFJDK-UHFFFAOYSA-N	327925	5-(4-(4-cyano-2- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 66::US9663496, Compound 66	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327925&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650325	384582841							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816748	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(F)(CC3)C(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-21-4-1-19(2-5-21)27(38)30(33)13-15-37(16-14-30)29(40)20-3-11-25(34-17-20)28(39)36-23-8-12-26(35-18-23)41-24-9-6-22(32)7-10-24/h1-12,17-18H,13-16H2,(H,36,39)	KJSYIIMVXXSKOC-UHFFFAOYSA-N	327926	5-(4-(4-fluoro-4- fluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 67::US9663496, Compound 67	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327926&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073146	384582842							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816749	Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	WQUGCKCCOOBUNT-UHFFFAOYSA-N	327927	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluoro-4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 68::US9663496, Compound 68	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327927&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073566	384582843							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816750	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O5/c1-40-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)22-4-12-27(33-18-22)30(38)35-24-7-13-28(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	LFVWKMPSGSNUPO-UHFFFAOYSA-N	327928	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 69::US9663496, Compound 69	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327928&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650328	384582844							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816751	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C30H27FN4O5/c1-38-23-8-10-24(11-9-23)39-26-14-16-35(17-15-26)30(37)20-2-12-27(32-18-20)29(36)34-22-5-13-28(33-19-22)40-25-6-3-21(31)4-7-25/h2-13,18-19,26H,14-17H2,1H3,(H,34,36)	UFHBGTJZBONLAE-UHFFFAOYSA-N	327929	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 70::US9663496, Compound 70	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327929&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650665	384582845							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816752	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H35N5O2/c36-29(32-27-13-15-33(16-14-27)22-24-7-3-1-4-8-24)28-12-11-26(21-31-28)30(37)35-19-17-34(18-20-35)23-25-9-5-2-6-10-25/h1-12,21,27H,13-20,22-23H2,(H,32,36)	OQMKCTWXRSKXFX-UHFFFAOYSA-N	327930	5-(4-benzylpiperazine-1- carbonyl)-N-(1- benzylpiperidin-4- yl)picolinamide::US10377742, Compound 72::US9663496, Compound 72	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327930&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650667	384582846							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816753	O=C(N1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C29H33N5O2/c35-28(33-17-13-31(14-18-33)22-24-7-3-1-4-8-24)26-11-12-27(30-21-26)29(36)34-19-15-32(16-20-34)23-25-9-5-2-6-10-25/h1-12,21H,13-20,22-23H2	HLMPLICAEPSBJM-UHFFFAOYSA-N	327931	US10377742, Compound 73::US9663496, Compound 73::pyridine-2,5-diylbis((4- benzylpiperazin-1- yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327931&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			4572076	384582847							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816754	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H35N5O2/c36-29(32-27-13-15-33(16-14-27)22-24-7-3-1-4-8-24)26-11-12-28(31-21-26)30(37)35-19-17-34(18-20-35)23-25-9-5-2-6-10-25/h1-12,21,27H,13-20,22-23H2,(H,32,36)	OOEKCGKFHYHSPV-UHFFFAOYSA-N	327932	6-(4-benzylpiperazine-1- carbonyl)-N-(1- benzylpiperidin-4- yl)nicotinamide::US10377742, Compound 74::US9663496, Compound 74	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327932&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073477	384582848							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816755	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C44H46N10O4/c45-25-31-1-5-33(6-2-31)29-51-17-13-37(14-18-51)49-41(55)39-11-9-35(27-47-39)43(57)53-21-23-54(24-22-53)44(58)36-10-12-40(48-28-36)42(56)50-38-15-19-52(20-16-38)30-34-7-3-32(26-46)4-8-34/h1-12,27-28,37-38H,13-24,29-30H2,(H,49,55)(H,50,56)	PQQKKQOBKNNYJV-UHFFFAOYSA-N	327933	5,5'-(piperazine-1,4- diylbis(oxomethylene))  bis(N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide)::US10377742, Compound 75::US9663496, Compound 75	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327933&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710375	384582849							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816756	Fc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31FN6O3/c32-26-8-5-24(6-9-26)30(40)37-15-17-38(18-16-37)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-36(14-12-27)21-23-3-1-22(19-33)2-4-23/h1-10,20,27H,11-18,21H2,(H,35,39)	RXZOTKZCZZFCCH-UHFFFAOYSA-N	327934	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 76::US9663496, Compound 76	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327934&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650668	384582850							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816757	COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-28-9-6-25(7-10-28)31(40)37-16-18-38(19-17-37)32(41)26-8-11-29(34-21-26)30(39)35-27-12-14-36(15-13-27)22-24-4-2-23(20-33)3-5-24/h2-11,21,27H,12-19,22H2,1H3,(H,35,39)	LXDHLOOAVAFEJF-UHFFFAOYSA-N	327935	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 77::US9663496, Compound 77	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327935&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650669	384582851							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816758	Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H31FN6O4S/c31-25-6-8-27(9-7-25)42(40,41)37-17-15-36(16-18-37)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-35(14-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,26H,11-18,21H2,(H,34,38)	MDZHPVWRGQFKCQ-UHFFFAOYSA-N	327936	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 78::US9663496, Compound 78	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327936&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651001	384582852							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816759	COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H34N6O5S/c1-42-27-7-9-28(10-8-27)43(40,41)37-18-16-36(17-19-37)31(39)25-6-11-29(33-21-25)30(38)34-26-12-14-35(15-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,26H,12-19,22H2,1H3,(H,34,38)	AVWVDLCYEHDFRA-UHFFFAOYSA-N	327937	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxyphenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 79::US9663496, Compound 79	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327937&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651002	384582853							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816760	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)c1ccccc1	InChI=1S/C31H32N6O3/c32-20-23-6-8-24(9-7-23)22-35-14-12-27(13-15-35)34-29(38)28-11-10-26(21-33-28)31(40)37-18-16-36(17-19-37)30(39)25-4-2-1-3-5-25/h1-11,21,27H,12-19,22H2,(H,34,38)	UZKLXKCSYXORTD-UHFFFAOYSA-N	327938	5-(4-benzoylpiperazine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 80::US9663496, Compound 80	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327938&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651003	384582854							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816761	CC(C)(C)C(=O)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C29H36N6O3/c1-29(2,3)28(38)35-16-14-34(15-17-35)27(37)23-8-9-25(31-19-23)26(36)32-24-10-12-33(13-11-24)20-22-6-4-21(18-30)5-7-22/h4-9,19,24H,10-17,20H2,1-3H3,(H,32,36)	BYANCVXDXHRQLT-UHFFFAOYSA-N	327939	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- pivaloylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 81::US9663496, Compound 81	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327939&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651004	384582855							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816762	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)S(=O)(=O)c1ccccc1	InChI=1S/C30H32N6O4S/c31-20-23-6-8-24(9-7-23)22-34-14-12-26(13-15-34)33-29(37)28-11-10-25(21-32-28)30(38)35-16-18-36(19-17-35)41(39,40)27-4-2-1-3-5-27/h1-11,21,26H,12-19,22H2,(H,33,37)	UFEIEYBIRIUWRQ-UHFFFAOYSA-N	327940	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(phenylsulfonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 82::US9663496, Compound 82	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327940&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651005	384582856							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816763	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C1CCOCC1	InChI=1S/C29H36N6O3/c30-19-22-1-3-23(4-2-22)21-33-11-7-25(8-12-33)32-28(36)27-6-5-24(20-31-27)29(37)35-15-13-34(14-16-35)26-9-17-38-18-10-26/h1-6,20,25-26H,7-18,21H2,(H,32,36)	NMCSHUMJBBZUEI-UHFFFAOYSA-N	327941	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(tetrahydro-2H- pyran-4-yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 83::US9663496, Compound 83	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327941&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710517	384582857							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816764	CC(C)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C27H34N6O2/c1-20(2)32-13-15-33(16-14-32)27(35)23-7-8-25(29-18-23)26(34)30-24-9-11-31(12-10-24)19-22-5-3-21(17-28)4-6-22/h3-8,18,20,24H,9-16,19H2,1-2H3,(H,30,34)	SXPSAQUONWUCPN-UHFFFAOYSA-N	327942	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- isopropylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 84::US9663496, Compound 84	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327942&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710694	384582858							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816765	Cc1cc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)no1	InChI=1S/C28H34N6O3/c1-21-17-25(31-37-21)20-33-13-15-34(16-14-33)28(36)23-7-8-26(29-18-23)27(35)30-24-9-11-32(12-10-24)19-22-5-3-2-4-6-22/h2-8,17-18,24H,9-16,19-20H2,1H3,(H,30,35)	GWJLUAVBJOJUAI-UHFFFAOYSA-N	327943	N-(1-benzylpiperidin-4- yl)-5-(4-((5- methylisoxazol-3- yl)methyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 85::US9663496, Compound 85	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327943&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710206	384582859							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816766	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1cccc(n1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N7O2/c34-20-24-4-8-26(9-5-24)22-39-16-12-28(13-17-39)36-32(41)30-2-1-3-31(38-30)33(42)37-29-14-18-40(19-15-29)23-27-10-6-25(21-35)7-11-27/h1-11,28-29H,12-19,22-23H2,(H,36,41)(H,37,42)	ZNLOQOLMQYQXNI-UHFFFAOYSA-N	327944	N2,N6-bis(1-(4- cyanobenzyl)piperidin-4- yl)pyridine-2,6- dicarboxamide::US10377742, Compound 86::US9663496, Compound 86	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327944&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710797	384582860							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816767	Fc1ccc(CN2CCC(CC2)NC(=O)c2cccc(n2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35F2N5O2/c32-24-8-4-22(5-9-24)20-37-16-12-26(13-17-37)34-30(39)28-2-1-3-29(36-28)31(40)35-27-14-18-38(19-15-27)21-23-6-10-25(33)11-7-23/h1-11,26-27H,12-21H2,(H,34,39)(H,35,40)	RKTWPHQFWGVWFF-UHFFFAOYSA-N	327945	N2,N6-bis(1-(4- fluorobenzyl)piperidin- 4-yl)pyridine-2,6- dicarboxamide::US10377742, Compound 87::US9663496, Compound 87	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327945&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710631	384582861							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816768	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(CCc3ccccc3)CC2)cc1	InChI=1S/C30H34FN5O2/c31-27-9-6-25(7-10-27)23-34-16-20-35(21-17-34)29(37)26-8-11-28(32-22-26)30(38)36-18-14-33(15-19-36)13-12-24-4-2-1-3-5-24/h1-11,22H,12-21,23H2	UKCFFODPBLWFIW-UHFFFAOYSA-N	327946	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-3- yl)methanone::US10377742, Compound 88::US9663496, Compound 88	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327946&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073510	384582862							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816769	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)C(=O)C1CCCCC1	InChI=1S/C31H38N6O3/c32-20-23-6-8-24(9-7-23)22-35-14-12-27(13-15-35)34-29(38)28-11-10-26(21-33-28)31(40)37-18-16-36(17-19-37)30(39)25-4-2-1-3-5-25/h6-11,21,25,27H,1-5,12-19,22H2,(H,34,38)	WFWVYMHDWSBWSD-UHFFFAOYSA-N	327947	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- (cyclohexanecarbonyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 89::US9663496, Compound 89	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327947&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710780	384582863							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816770	O=C(N1CCN(CC1)c1ccccc1)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C29H33N5O2/c35-28(33-21-19-32(20-22-33)26-9-5-2-6-10-26)25-11-12-27(30-23-25)29(36)34-17-15-31(16-18-34)14-13-24-7-3-1-4-8-24/h1-12,23H,13-22H2	DILDXNXKQQSZDE-UHFFFAOYSA-N	327948	(4-phenethylpiperazin-1- yl)(5-(4- phenylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 90::US9663496, Compound 90	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327948&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073255	384582864							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816771	CC(C)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C26H35N5O2/c1-21(2)29-16-18-30(19-17-29)25(32)23-8-9-24(27-20-23)26(33)31-14-12-28(13-15-31)11-10-22-6-4-3-5-7-22/h3-9,20-21H,10-19H2,1-2H3	WELVWANXLGVWPI-UHFFFAOYSA-N	327949	(4-isopropylpiperazin-1- yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-3- yl)methanone::US10377742, Compound 91::US9663496, Compound 91	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327949&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073430	384582865							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816772	O=C(N1CCN(CCc2ccccc2)CC1)c1ccc(nc1)C(=O)N1CCN(CCc2ccccc2)CC1	InChI=1S/C31H37N5O2/c37-30(35-21-17-33(18-22-35)15-13-26-7-3-1-4-8-26)28-11-12-29(32-25-28)31(38)36-23-19-34(20-24-36)16-14-27-9-5-2-6-10-27/h1-12,25H,13-24H2	XIBAGROKRXXCJI-UHFFFAOYSA-N	327950	US10377742, Compound 92::US9663496, Compound 92::pyridine-2,5-diylbis((4- phenethylpiperazin-1- yl)methanone)	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327950&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073439	384582866							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816773	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)N2CCN(CCc3ccccc3)CC2)cc1	InChI=1S/C30H34FN5O2/c31-26-11-9-25(10-12-26)23-34-17-21-36(22-18-34)30(38)28-8-4-7-27(32-28)29(37)35-19-15-33(16-20-35)14-13-24-5-2-1-3-6-24/h1-12H,13-23H2	KXOMWEWZJKBODO-UHFFFAOYSA-N	327956	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenethylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 93::US9663496, Compound 93	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327956&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073536	384582872							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816774	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)N2CCN(CC2)c2ccccc2)cc1	InChI=1S/C28H30FN5O2/c29-23-11-9-22(10-12-23)21-31-13-15-33(16-14-31)27(35)25-7-4-8-26(30-25)28(36)34-19-17-32(18-20-34)24-5-2-1-3-6-24/h1-12H,13-21H2	HOVNBOLMJBLKSZ-UHFFFAOYSA-N	327957	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenylpiperazine-1- carbonyl)pyridin-2- yl)methanone::US10377742, Compound 94::US9663496, Compound 94	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327957&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073228	384582873							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816775	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC2CCCCC2)CC1	InChI=1S/C31H40N6O2/c32-20-24-6-8-26(9-7-24)23-35-14-12-28(13-15-35)34-30(38)29-11-10-27(21-33-29)31(39)37-18-16-36(17-19-37)22-25-4-2-1-3-5-25/h6-11,21,25,28H,1-5,12-19,22-23H2,(H,34,38)	YJICAVIHOWJTJS-UHFFFAOYSA-N	327958	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4- (cyclohexylmethyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 95::US9663496, Compound 95	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327958&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710462	384582874							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816776	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccncc1	InChI=1S/C28H32N6O2/c35-27(31-24-10-14-32(15-11-24)21-22-4-2-1-3-5-22)26-7-6-23(20-30-26)28(36)34-18-16-33(17-19-34)25-8-12-29-13-9-25/h1-9,12-13,20,24H,10-11,14-19,21H2,(H,31,35)	LZSZSQKOWNJKPK-UHFFFAOYSA-N	327959	N-(1-benzylpiperidin-4- yl)-5-(4-(pyridin-4- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 96::US9663496, Compound 96	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327959&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710310	384582875							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816777	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccccc1	InChI=1S/C29H33N5O2/c35-28(31-25-13-15-32(16-14-25)22-23-7-3-1-4-8-23)27-12-11-24(21-30-27)29(36)34-19-17-33(18-20-34)26-9-5-2-6-10-26/h1-12,21,25H,13-20,22H2,(H,31,35)	UHYHAUUNDGYPEZ-UHFFFAOYSA-N	327960	N-(1-benzylpiperidin-4- yl)-5-(4- phenylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 97::US9663496, Compound 97	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327960&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710805	384582876							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816778	CCOC(=O)C(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1	InChI=1S/C33H38FN5O4/c1-2-43-33(42)30(25-6-4-3-5-7-25)38-16-14-28(15-17-38)36-31(40)29-13-10-26(22-35-29)32(41)39-20-18-37(19-21-39)23-24-8-11-27(34)12-9-24/h3-13,22,28,30H,2,14-21,23H2,1H3,(H,36,40)	FKZQMJSSWXQOPZ-UHFFFAOYSA-N	327961	US10377742, Compound 98::US9663496, Compound 98::ethyl 2-(4-(5-(4-(4- fluorobenzyl)piperazine- 1- carbonyl)picolinamido)  piperidin-1-yl)-2- phenylacetate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327961&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710360	384582877							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816779	Fc1ccc(CN2CCN(CC2)C(=O)c2cccc(n2)C(=O)NC2CCC(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-27-12-8-26(9-13-27)22-37-16-18-38(19-17-37)32(40)30-3-1-2-29(36-30)31(39)35-28-14-10-24(11-15-28)20-23-4-6-25(21-34)7-5-23/h1-9,12-13,24,28H,10-11,14-20,22H2,(H,35,39)	DDXGSXLONGRSHS-UHFFFAOYSA-N	327962	N-(4-(4-cyanobenzyl)  cyclohexyl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 99::US9663496, Compound 99	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327962&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710673	384582878							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816780	F[C@H]1CN(Cc2ccc(cc2)C#N)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C31H32F2N6O2/c32-26-8-5-24(6-9-26)19-37-13-15-39(16-14-37)31(41)25-7-10-29(35-18-25)30(40)36-28-11-12-38(21-27(28)33)20-23-3-1-22(17-34)2-4-23/h1-10,18,27-28H,11-16,19-21H2,(H,36,40)/t27-,28+/m0/s1	GGMOGBNZFSCMDK-WUFINQPMSA-N	327963	US10377742, Compound 100::US9663496, Compound 100::cis-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327963&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084716	384582879							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816781	COc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O3/c1-41-29-9-6-26(7-10-29)23-37-16-18-38(19-17-37)32(40)27-8-11-30(34-21-27)31(39)35-28-12-14-36(15-13-28)22-25-4-2-24(20-33)3-5-25/h2-11,21,28H,12-19,22-23H2,1H3,(H,35,39)	WPSUUXHDAQDYPG-UHFFFAOYSA-N	327964	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 101::US9663496, Compound 101	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327964&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710623	384582880							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816782	F[C@H]1CNCC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C23H27F2N5O2/c24-18-4-1-16(2-5-18)15-29-9-11-30(12-10-29)23(32)17-3-6-21(27-13-17)22(31)28-20-7-8-26-14-19(20)25/h1-6,13,19-20,26H,7-12,14-15H2,(H,28,31)/t19-,20+/m0/s1	SSXKELDQHCLBAC-VQTJNVASSA-N	327965	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(cis-3- fluoropiperidin-4- yl)picolinamide::US10377742, Compound 102::US9663496, Compound 102	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327965&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710572	384582881							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816783	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccncc2)CC1	InChI=1S/C30H33N7O2/c31-19-23-1-3-24(4-2-23)21-35-13-9-27(10-14-35)34-29(38)28-6-5-26(20-33-28)30(39)37-17-15-36(16-18-37)22-25-7-11-32-12-8-25/h1-8,11-12,20,27H,9-10,13-18,21-22H2,(H,34,38)	RMUCYZDCFKRSNY-UHFFFAOYSA-N	327966	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(pyridin-4- ylmethyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 103::US9663496, Compound 103	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327966&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710289	384582882							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816784	F[C@H]1CN(Cc2ccncc2)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C29H32F2N6O2/c30-24-4-1-21(2-5-24)18-35-13-15-37(16-14-35)29(39)23-3-6-27(33-17-23)28(38)34-26-9-12-36(20-25(26)31)19-22-7-10-32-11-8-22/h1-8,10-11,17,25-26H,9,12-16,18-20H2,(H,34,38)/t25-,26+/m0/s1	KMRPXMWIZLSCAG-IZZNHLLZSA-N	327967	N-(cis-3-fluoro-1- (pyridin-4- ylmethyl)piperidin-4-yl)- 5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 104::US9663496, Compound 104	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327967&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710307	384582883							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816785	O=C(Nc1ccc(cc1)-c1ccccc1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H30N4O2/c36-30(33-27-14-11-25(12-15-27)24-9-5-2-6-10-24)26-13-16-29(32-21-26)31(37)34-28-17-19-35(20-18-28)22-23-7-3-1-4-8-23/h1-16,21,28H,17-20,22H2,(H,33,36)(H,34,37)	CWIOPRLBOMZPKA-UHFFFAOYSA-N	327968	N2-(1-benzylpiperidin-4- yl)-N5-(biphenyl-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 105::US9663496, Compound 105	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327968&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710362	384582884							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816786	O=C(Nc1cccc(c1)-c1ccccc1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H30N4O2/c36-30(34-28-13-7-12-25(20-28)24-10-5-2-6-11-24)26-14-15-29(32-21-26)31(37)33-27-16-18-35(19-17-27)22-23-8-3-1-4-9-23/h1-15,20-21,27H,16-19,22H2,(H,33,37)(H,34,36)	RUQCHWUZRNYFAS-UHFFFAOYSA-N	327969	N2-(1-benzylpiperidin-4- yl)-N5-(biphenyl-3- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 106::US9663496, Compound 106	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327969&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710236	384582885							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816787	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2)cc1	InChI=1S/C24H23FN4O2/c25-20-9-6-18(7-10-20)17-28-12-14-29(15-13-28)24(31)19-8-11-22(26-16-19)23(30)27-21-4-2-1-3-5-21/h1-11,16H,12-15,17H2,(H,27,30)	VLEVKLAKDLKCFK-UHFFFAOYSA-N	327970	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N- phenylpicolinamide::US10377742, Compound 107::US9663496, Compound 107	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327970&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710223	384582886							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816788	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Nc2ccc(Cc3ccccc3)cc2)cn1	InChI=1S/C32H31N5O/c33-21-26-6-8-27(9-7-26)23-37-18-16-29(17-19-37)36-32(38)31-15-14-30(22-34-31)35-28-12-10-25(11-13-28)20-24-4-2-1-3-5-24/h1-15,22,29,35H,16-20,23H2,(H,36,38)	ZTXYRALKNNXSHH-UHFFFAOYSA-N	409083	5-(4-benzylphenylamino)-N-(1-(4- cyanobenzyl)piperidin-4-yl)picolinamide::US10377742, Compound 108	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409083&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710290	406799703							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816789	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(Nc2ccc(cc2)-c2ccccc2)cn1	InChI=1S/C31H29N5O/c32-20-23-6-8-24(9-7-23)22-36-18-16-28(17-19-36)35-31(37)30-15-14-29(21-33-30)34-27-12-10-26(11-13-27)25-4-2-1-3-5-25/h1-15,21,28,34H,16-19,22H2,(H,35,37)	XECSTZQZWRCGSO-UHFFFAOYSA-N	327972	5-(biphenyl-4-ylamino)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 109::US9663496, Compound 109	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327972&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710499	384582888							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816790	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCN(Cc2ccccc2)CC1	InChI=1S/C30H34N6O/c31-20-24-6-8-26(9-7-24)23-34-14-12-27(13-15-34)33-30(37)29-11-10-28(21-32-29)36-18-16-35(17-19-36)22-25-4-2-1-3-5-25/h1-11,21,27H,12-19,22-23H2,(H,33,37)	TUXSVDQMBSARPI-UHFFFAOYSA-N	327973	5-(4-benzylpiperazin-1- yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 110::US9663496, Compound 110	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327973&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710221	384582889							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816791	CC(C)(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccc(cc1)C#N	InChI=1S/C33H37FN6O2/c1-33(2,27-8-3-24(21-35)4-9-27)40-15-13-29(14-16-40)37-31(41)30-12-7-26(22-36-30)32(42)39-19-17-38(18-20-39)23-25-5-10-28(34)11-6-25/h3-12,22,29H,13-20,23H2,1-2H3,(H,37,41)	PJUPLDXIIBQNBZ-UHFFFAOYSA-N	327974	N-(1-(2-(4- cyanophenyl)propan-2- yl)piperidin-4-yl)-5-(4- (4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 111::US9663496, Compound 111	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327974&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710432	384582890							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816792	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2cccc(Oc3ccccc3)c2)cn1	InChI=1S/C30H30N4O2/c35-30(33-24-16-18-34(19-17-24)22-23-8-3-1-4-9-23)29-15-14-26(21-31-29)32-25-10-7-13-28(20-25)36-27-11-5-2-6-12-27/h1-15,20-21,24,32H,16-19,22H2,(H,33,35)	SIUGKYLYXCIBJK-UHFFFAOYSA-N	327975	N-(1-benzylpiperidin-4- yl)-5-(3- phenoxyphenylamino)  picolinamide::US10377742, Compound 112::US9663496, Compound 112	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327975&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710737	384582891							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816793	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2ccc(Oc3ccccc3)cc2)cn1	InChI=1S/C30H30N4O2/c35-30(33-25-17-19-34(20-18-25)22-23-7-3-1-4-8-23)29-16-13-26(21-31-29)32-24-11-14-28(15-12-24)36-27-9-5-2-6-10-27/h1-16,21,25,32H,17-20,22H2,(H,33,35)	DBXTZCORMIZYNR-UHFFFAOYSA-N	327976	N-(1-benzylpiperidin-4- yl)-5-(4- phenoxyphenylamino)  picolinamide::US10377742, Compound 113::US9663496, Compound 113	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327976&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710621	384582892							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816794	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(Nc2cccc(c2)-c2ccccc2)cn1	InChI=1S/C30H30N4O/c35-30(33-26-16-18-34(19-17-26)22-23-8-3-1-4-9-23)29-15-14-28(21-31-29)32-27-13-7-12-25(20-27)24-10-5-2-6-11-24/h1-15,20-21,26,32H,16-19,22H2,(H,33,35)	ALWPRGJHZOZRBU-UHFFFAOYSA-N	327977	N-(1-benzylpiperidin-4- yl)-5-(biphenyl-3- ylamino)picolinamide::US10377742, Compound 114::US9663496, Compound 114	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327977&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710249	384582893							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816795	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NCc2ccccc2)cc1	InChI=1S/C25H25FN4O2/c26-22-9-6-20(7-10-22)18-29-12-14-30(15-13-29)25(32)21-8-11-23(27-17-21)24(31)28-16-19-4-2-1-3-5-19/h1-11,17H,12-16,18H2,(H,28,31)	SFBUXGKMWDVQSW-UHFFFAOYSA-N	327978	N-benzyl-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 115::US9663496, Compound 115	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327978&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710681	384582894							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816796	O=C(NCc1ccccc1)c1ccc(cn1)C(=O)N1CCN(Cc2ccccc2)CC1	InChI=1S/C25H26N4O2/c30-24(27-17-20-7-3-1-4-8-20)23-12-11-22(18-26-23)25(31)29-15-13-28(14-16-29)19-21-9-5-2-6-10-21/h1-12,18H,13-17,19H2,(H,27,30)	LYNNCHNXFHBVFJ-UHFFFAOYSA-N	327979	N-benzyl-5-(4- benzylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 116::US9663496, Compound 116	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327979&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710498	384582895							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816797	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H36FN5O3/c1-40-28-9-4-24(5-10-28)21-35-14-12-27(13-15-35)34-30(38)29-11-6-25(20-33-29)31(39)37-18-16-36(17-19-37)22-23-2-7-26(32)8-3-23/h2-11,20,27H,12-19,21-22H2,1H3,(H,34,38)	JBOAVLPHPAENSA-UHFFFAOYSA-N	327980	5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 117::US9663496, Compound 117	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327980&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710497	384582896							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816798	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(cc3)C#N)C2)cc1	InChI=1S/C30H31FN6O2/c31-26-8-5-24(6-9-26)19-35-13-15-37(16-14-35)30(39)25-7-10-28(33-18-25)29(38)34-27-11-12-36(21-27)20-23-3-1-22(17-32)2-4-23/h1-10,18,27H,11-16,19-21H2,(H,34,38)/t27-/m1/s1	ZTMNZDLYLCMZAQ-HHHXNRCGSA-N	327981	(R)-N-(1-(4- cyanobenzyl)pyrrolidin- 3-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 118::US9663496, Compound 118	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327981&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710214	384582897							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816799	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(=O)c1ccc(cc1)-c1ccc(cc1)C#N	InChI=1S/C32H28N4O2/c33-20-23-6-8-25(9-7-23)26-10-12-27(13-11-26)31(37)28-14-15-30(34-21-28)32(38)35-29-16-18-36(19-17-29)22-24-4-2-1-3-5-24/h1-15,21,29H,16-19,22H2,(H,35,38)	GANGHIHRMAAXQS-UHFFFAOYSA-N	409094	N-(1-benzylpiperidin-4-yl)-5-(4'- cyanobiphenyl-4-ylamino)picolinamide::US10377742, Compound 119	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409094&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300124	406799714							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816800	COc1ccc(cc1)-c1ccc(Nc2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	InChI=1S/C31H32N4O2/c1-37-29-14-9-25(10-15-29)24-7-11-26(12-8-24)33-28-13-16-30(32-21-28)31(36)34-27-17-19-35(20-18-27)22-23-5-3-2-4-6-23/h2-16,21,27,33H,17-20,22H2,1H3,(H,34,36)	YAMQWOAVLNMDPS-UHFFFAOYSA-N	327983	N-(1-benzylpiperidin-4- yl)-5-(4'- methoxybiphenyl-4- ylamino)picolinamide::US10377742, Compound 120::US9663496, Compound 120	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327983&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710250	384582899							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816801	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)-c1cn(Cc2ccccc2)nn1	InChI=1S/C28H27N7O/c29-16-21-6-8-23(9-7-21)18-34-14-12-25(13-15-34)31-28(36)26-11-10-24(17-30-26)27-20-35(33-32-27)19-22-4-2-1-3-5-22/h1-11,17,20,25H,12-15,18-19H2,(H,31,36)	WSQFHPOHNFIYFY-UHFFFAOYSA-N	327984	5-(1-benzyl-1H-1,2,3- triazol-4-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 121::US9663496, Compound 121	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327984&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710438	384582900							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816802	Fc1ccc(CN2CCN(CC2=O)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	InChI=1S/C30H32FN5O3/c31-25-9-6-23(7-10-25)20-35-16-17-36(21-28(35)37)30(39)24-8-11-27(32-18-24)29(38)33-26-12-14-34(15-13-26)19-22-4-2-1-3-5-22/h1-11,18,26H,12-17,19-21H2,(H,33,38)	YNMMLVPNDUXLQQ-UHFFFAOYSA-N	327985	5-(1-benzyl-1H-1,2,3- triazol-4-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 122::US9663496, Compound 122	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327985&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			68084719	384582901							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816803	Fc1ccc(CN2CCN(CC2=O)C(=O)c2ccc(nc2)C(=O)N[C@H]2CCN(Cc3ccc(cc3)C#N)C2)cc1	InChI=1S/C30H29FN6O3/c31-25-8-5-23(6-9-25)18-36-13-14-37(20-28(36)38)30(40)24-7-10-27(33-16-24)29(39)34-26-11-12-35(19-26)17-22-3-1-21(15-32)2-4-22/h1-10,16,26H,11-14,17-20H2,(H,34,39)/t26-/m0/s1	CKXPBSUKGATDRJ-SANMLTNESA-N	409098	(S)-N-(1-(4-cyanobenzyl)pyrrolidin- 3-yl)-5- (4-(4-fluorobenzyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 123	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409098&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300113	406799718							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816804	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(Cc2ccccc2)CC1	InChI=1S/C32H35N5O2/c33-21-26-6-8-27(9-7-26)23-36-16-14-29(15-17-36)35-31(38)30-11-10-28(22-34-30)32(39)37-18-12-25(13-19-37)20-24-4-2-1-3-5-24/h1-11,22,25,29H,12-20,23H2,(H,35,38)	UHPFGVZAKOCMFD-UHFFFAOYSA-N	409099	5-(4-benzylpiperidine-1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4-yl)picolinamide::US10377742, Compound 124	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409099&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710287	406799719							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816805	CC1(C)CN(CCN1Cc1ccc(F)cc1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H37FN6O2/c1-33(2)23-39(17-18-40(33)22-26-7-10-28(34)11-8-26)32(42)27-9-12-30(36-20-27)31(41)37-29-13-15-38(16-14-29)21-25-5-3-24(19-35)4-6-25/h3-12,20,29H,13-18,21-23H2,1-2H3,(H,37,41)	CCVJKVSSPUWIOG-UHFFFAOYSA-N	327988	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzyl)-3,3- dimethylpiperazine-1- carbonyl)picolinamide::US10377742, Compound 125::US9663496, Compound 125	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327988&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710341	384582904							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816806	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(NC2CCN(CC2)c2ccccc2)cn1	InChI=1S/C30H34N6O/c31-20-23-6-8-24(9-7-23)22-35-16-12-26(13-17-35)34-30(37)29-11-10-27(21-32-29)33-25-14-18-36(19-15-25)28-4-2-1-3-5-28/h1-11,21,25-26,33H,12-19,22H2,(H,34,37)	CQIGWVFBNAADFU-UHFFFAOYSA-N	327989	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-phenylpiperidin- 4-ylamino)picolinamide::US10377742, Compound 126::US9663496, Compound 126	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327989&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710671	384582905							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816807	F[C@H]1CN(Cc2ccc(Cl)cc2)CC[C@H]1NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H32ClF2N5O2/c31-24-6-1-21(2-7-24)19-37-12-11-27(26(33)20-37)35-29(39)28-10-5-23(17-34-28)30(40)38-15-13-36(14-16-38)18-22-3-8-25(32)9-4-22/h1-10,17,26-27H,11-16,18-20H2,(H,35,39)/t26-,27+/m0/s1	QFCGCJFUXOLOOW-RRPNLBNLSA-N	327990	N-(cis-1-(4- chlorobenzyl)-3- fluoropiperidin-4-yl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 127::US9663496, Compound 127	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327990&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710363	384582906							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816808	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H34N6O2/c34-20-26-3-1-24(2-4-26)19-25-11-17-39(18-12-25)33(41)29-9-10-31(36-22-29)32(40)37-30-13-15-38(16-14-30)23-28-7-5-27(21-35)6-8-28/h1-10,22,25,30H,11-19,23H2,(H,37,40)	MRMDURIHTGUZQI-UHFFFAOYSA-N	327991	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 128::US9663496, Compound 128	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327991&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710600	384582907							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816809	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	POEZYVXOVVWICH-UHFFFAOYSA-N	327992	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 129::US9663496, Compound 129	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327992&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710523	384582908							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816810	Fc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-28-8-5-23(6-9-28)19-24-11-17-38(18-12-24)32(40)27-7-10-30(35-21-27)31(39)36-29-13-15-37(16-14-29)22-26-3-1-25(20-34)2-4-26/h1-10,21,24,29H,11-19,22H2,(H,36,39)	NDMQOBJALHHUBI-UHFFFAOYSA-N	327993	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 130::US9663496, Compound 130	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327993&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710624	384582909							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816811	COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H37N5O3/c1-41-30-9-6-24(7-10-30)20-25-12-18-38(19-13-25)33(40)28-8-11-31(35-22-28)32(39)36-29-14-16-37(17-15-29)23-27-4-2-26(21-34)3-5-27/h2-11,22,25,29H,12-20,23H2,1H3,(H,36,39)	CXYVYGXMFQSTKH-UHFFFAOYSA-N	327994	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 131::US9663496, Compound 131	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327994&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710649	384582910							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816812	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc3CCN(Cc4ccc(cc4)C#N)Cc3c2)cc1	InChI=1S/C35H33FN6O2/c36-31-9-5-27(6-10-31)22-40-15-17-42(18-16-40)35(44)29-8-12-33(38-21-29)34(43)39-32-11-7-28-13-14-41(24-30(28)19-32)23-26-3-1-25(20-37)2-4-26/h1-12,19,21H,13-18,22-24H2,(H,39,43)	BIPLDIXMEWFTMU-UHFFFAOYSA-N	409107	N-(2-(4-cyanobenzyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-5-(4-(4- fluorobenzyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 132	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409107&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710530	406799727							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816813	CC(C)(N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccccc1	InChI=1S/C33H38N6O2/c1-33(2,28-6-4-3-5-7-28)39-20-18-38(19-21-39)32(41)27-12-13-30(35-23-27)31(40)36-29-14-16-37(17-15-29)24-26-10-8-25(22-34)9-11-26/h3-13,23,29H,14-21,24H2,1-2H3,(H,36,40)	ANTKASWXMLJFBB-UHFFFAOYSA-N	327996	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2- phenylpropan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 133::US9663496, Compound 133	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327996&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710761	384582912							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816814	Clc1ccc(cc1)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32ClN5O2/c32-27-8-5-24(6-9-27)25-11-17-37(18-12-25)31(39)26-7-10-29(34-20-26)30(38)35-28-13-15-36(16-14-28)21-23-3-1-22(19-33)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,35,38)	IDMGMBXNNCRUAB-UHFFFAOYSA-N	327997	5-(4-(4- chlorophenyl)piperidine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 134::US9663496, Compound 134	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327997&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710528	384582913							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816815	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-26(21-35-30)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)	BPMMMRKHRUQAAY-UHFFFAOYSA-N	327998	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 135::US9663496, Compound 135	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327998&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710291	384582914							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816816	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32FN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,36,40)	QZCUYXGDXFPQEA-UHFFFAOYSA-N	327999	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 136::US9663496, Compound 136	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=327999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=327999&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710317	384582915							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816817	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCCC(C1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-18-23-3-5-25(6-4-23)21-37-16-13-27(14-17-37)36-31(39)30-12-9-26(20-35-30)32(40)38-15-1-2-29(22-38)41-28-10-7-24(19-34)8-11-28/h3-12,20,27,29H,1-2,13-17,21-22H2,(H,36,39)	WJFHULPMCHGBBX-UHFFFAOYSA-N	328000	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 137::US9663496, Compound 137	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328000&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710280	384582916							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816818	FC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1	InChI=1S/C32H33F2N5O2/c33-27-8-5-24(6-9-27)30(34)25-11-17-39(18-12-25)32(41)26-7-10-29(36-20-26)31(40)37-28-13-15-38(16-14-28)21-23-3-1-22(19-35)2-4-23/h1-10,20,25,28,30H,11-18,21H2,(H,37,40)	FJNHSBVZTQFKEF-UHFFFAOYSA-N	328001	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro(4- fluorophenyl)methyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 138::US9663496, Compound 138	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328001&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710312	384582917							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816819	Clc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H33ClN6O/c31-24-5-8-28(9-6-24)37-17-13-25(14-18-37)34-27-7-10-29(33-20-27)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,25-26,34H,11-18,21H2,(H,35,38)	AUDCQJXZPQEOHW-UHFFFAOYSA-N	328002	5-(1-(4- chlorophenyl)piperidin- 4-ylamino)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 139::US9663496, Compound 139	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328002&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710586	384582918							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816820	Fc1cc(F)cc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C31H32F2N6O2/c32-26-15-24(16-27(33)17-26)21-38-11-13-39(14-12-38)31(41)25-5-6-29(35-19-25)30(40)36-28-7-9-37(10-8-28)20-23-3-1-22(18-34)2-4-23/h1-6,15-17,19,28H,7-14,20-21H2,(H,36,40)	PXNMSZNSQODFJQ-UHFFFAOYSA-N	328003	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,5- difluorobenzyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 140::US9663496, Compound 140	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328003&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710477	384582919							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816821	O=CNc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H36N6O3/c34-20-26-1-3-27(4-2-26)22-38-15-13-30(14-16-38)37-32(41)31-10-7-28(21-35-31)33(42)39-17-11-25(12-18-39)19-24-5-8-29(9-6-24)36-23-40/h1-10,21,23,25,30H,11-19,22H2,(H,36,40)(H,37,41)	WKUIULCVDXQQPD-UHFFFAOYSA-N	409116	5-(4-(4-carbamoylbenzyl)piperidine-1- carbonyl)-N-(1-(4-cyanobenzyl) piperidin-4- yl)picolinamide::US10377742, Compound 141	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409116&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676187	406790692					C06049		1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816822	OC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1	InChI=1S/C32H34FN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28,30,39H,11-18,21H2,(H,36,40)	WNLKAYDTKKISBN-UHFFFAOYSA-N	328005	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-((4- fluorophenyl)(hydroxy)  methyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 142::US9663496, Compound 142	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328005&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710385	384582921							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816823	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-9-28(10-8-27)41-29-14-18-37(19-15-29)32(39)25-6-11-30(34-21-25)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	OFPXCBKYWWZZGT-UHFFFAOYSA-N	328006	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 143::US9663496, Compound 143	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328006&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710345	384582922							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816824	Fc1ccc(CNC(=O)c2ccc(nc2)C(=O)Nc2ccc3CCN(Cc4ccc(cc4)C#N)Cc3c2)cc1	InChI=1S/C31H26FN5O2/c32-27-9-5-22(6-10-27)17-35-30(38)25-8-12-29(34-18-25)31(39)36-28-11-7-24-13-14-37(20-26(24)15-28)19-23-3-1-21(16-33)2-4-23/h1-12,15,18H,13-14,17,19-20H2,(H,35,38)(H,36,39)	NAUIMQDUCLBJRJ-UHFFFAOYSA-N	328007	N2-(2-(4-cyanobenzyl)- 1,2,3,4- tetrahydroisoquinolin-7- yl)-N5-(4- fluorobenzyl)pyridine- 2,5-dicarboxamide::US10377742, Compound 144::US9663496, Compound 144	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328007&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710257	384582923							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816825	Cc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H37N5O2/c1-24-2-4-25(5-3-24)20-26-12-18-38(19-13-26)33(40)29-10-11-31(35-22-29)32(39)36-30-14-16-37(17-15-30)23-28-8-6-27(21-34)7-9-28/h2-11,22,26,30H,12-20,23H2,1H3,(H,36,39)	GAXYQFRRJQSHAN-UHFFFAOYSA-N	328008	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methylbenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 145::US9663496, Compound 145	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328008&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710568	384582924							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816826	COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1F	InChI=1S/C33H36FN5O3/c1-42-31-9-6-26(19-29(31)34)18-23-10-16-39(17-11-23)33(41)27-7-8-30(36-21-27)32(40)37-28-12-14-38(15-13-28)22-25-4-2-24(20-35)3-5-25/h2-9,19,21,23,28H,10-18,22H2,1H3,(H,37,40)	XGUKVBQSHUARJJ-UHFFFAOYSA-N	328009	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3-fluoro-4- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 146::US9663496, Compound 146	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328009&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710532	384582925							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816827	COc1cccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C33H37N5O3/c1-41-30-4-2-3-27(20-30)19-24-11-17-38(18-12-24)33(40)28-9-10-31(35-22-28)32(39)36-29-13-15-37(16-14-29)23-26-7-5-25(21-34)6-8-26/h2-10,20,22,24,29H,11-19,23H2,1H3,(H,36,39)	SBPPXQVCQDZTHN-UHFFFAOYSA-N	328010	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3- methoxybenzyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 147::US9663496, Compound 147	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328010&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710487	384582926							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816828	Fc1ccc(OCCNC(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C28H28FN5O3/c29-23-6-8-25(9-7-23)37-16-13-31-27(35)22-5-10-26(32-18-22)28(36)33-24-11-14-34(15-12-24)19-21-3-1-20(17-30)2-4-21/h1-10,18,24H,11-16,19H2,(H,31,35)(H,33,36)	DENRPACRNJYZDG-UHFFFAOYSA-N	328011	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(2-(4- fluorophenoxy)ethyl)  pyridine-2,5- dicarboxamide::US10377742, Compound 149::US9663496, Compound 149	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328011&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710539	384582927							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816829	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)24-5-14-29(34-20-24)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-7,10-11,14,20,26,28H,8-9,12-13,15-18,21H2,(H,35,38)/t26-,28+	GIQKDCHBWREEQP-DBAYTGFXSA-N	328012	N-(cis-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 150::US9663496, Compound 150	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328012&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56650666	384582928							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816830	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31FN4O4/c33-25-6-3-22(4-7-25)30(38)23-15-17-37(18-16-23)32(40)24-5-14-29(35-20-24)31(39)36-26-8-12-28(13-9-26)41-27-10-1-21(19-34)2-11-27/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,36,39)/t26-,28+	KILULKZXXSWNCI-DBAYTGFXSA-N	328013	N-(trans-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzoyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 151::US9663496, Compound 151	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328013&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073275	384582929							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816831	Fc1ccc(CC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-28-10-7-23(8-11-28)18-26-2-1-15-38(22-26)32(40)27-9-12-30(35-20-27)31(39)36-29-13-16-37(17-14-29)21-25-5-3-24(19-34)4-6-25/h3-12,20,26,29H,1-2,13-18,21-22H2,(H,36,39)	SWDLJAZQRMNAGX-UHFFFAOYSA-N	328014	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 152::US9663496, Compound 152	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328014&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710625	384582930							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816832	Fc1ccc(CC2CCCCN2C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34FN5O2/c33-27-11-8-23(9-12-27)19-29-3-1-2-16-38(29)32(40)26-10-13-30(35-21-26)31(39)36-28-14-17-37(18-15-28)22-25-6-4-24(20-34)5-7-25/h4-13,21,28-29H,1-3,14-19,22H2,(H,36,39)	KABCVIPOCMQHMB-UHFFFAOYSA-N	328015	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(2-(4- fluorobenzyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 153::US9663496, Compound 153	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328015&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710460	384582931							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816833	Clc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32ClN5O3/c33-27-8-5-24(6-9-27)30(39)25-11-17-38(18-12-25)32(41)26-7-10-29(35-20-26)31(40)36-28-13-15-37(16-14-28)21-23-3-1-22(19-34)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,36,40)	AKNRXDGPROARKE-UHFFFAOYSA-N	328016	5-(4-(4-chlorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 154::US9663496, Compound 154	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328016&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710303	384582932							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816834	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1cccc(c1)C#N	InChI=1S/C32H32N6O3/c33-19-23-4-6-24(7-5-23)22-37-14-10-27(11-15-37)36-31(39)30-9-8-26(21-35-30)32(40)38-16-12-28(13-17-38)41-29-3-1-2-25(18-29)20-34/h1-9,18,21,27-28H,10-17,22H2,(H,36,39)	FGBIWVHUOKXSKR-UHFFFAOYSA-N	328017	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3- cyanophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 155::US9663496, Compound 155	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328017&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710793	384582933							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816835	Clc1cc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)ccc1C#N	InChI=1S/C32H31ClN6O3/c33-29-17-28(7-5-24(29)19-35)42-27-11-15-39(16-12-27)32(41)25-6-8-30(36-20-25)31(40)37-26-9-13-38(14-10-26)21-23-3-1-22(18-34)2-4-23/h1-8,17,20,26-27H,9-16,21H2,(H,37,40)	GLIPJVAVLQRNNM-UHFFFAOYSA-N	328018	5-(4-(3-chloro-4- cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 156::US9663496, Compound 156	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328018&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710305	384582934							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816836	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O3/c33-32(34,35)25-6-8-27(9-7-25)43-28-13-17-40(18-14-28)31(42)24-5-10-29(37-20-24)30(41)38-26-11-15-39(16-12-26)21-23-3-1-22(19-36)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,38,41)	SWFYJWRPKQUXJE-UHFFFAOYSA-N	328019	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 157::US9663496, Compound 157	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328019&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710652	384582935							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816837	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1F	InChI=1S/C31H31F2N5O3/c32-27-7-6-26(17-28(27)33)41-25-11-15-38(16-12-25)31(40)23-5-8-29(35-19-23)30(39)36-24-9-13-37(14-10-24)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,24-25H,9-16,20H2,(H,36,39)	BUTSOOYTBYLGPV-UHFFFAOYSA-N	328020	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 158::US9663496, Compound 158	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328020&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710554	384582936							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816838	Fc1ccc(CN2CCN(CC2)C(=O)c2cnc(C(=O)NC3CCN(Cc4ccc(cc4)C#N)CC3)c(c2)C#CCNC(=O)COCCOCCOCCOCCNC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1	InChI=1S/C54H69FN10O9S/c55-44-13-11-41(12-14-44)36-64-21-23-65(24-22-64)53(69)43-32-42(50(59-34-43)52(68)60-45-15-19-63(20-16-45)35-40-9-7-39(33-56)8-10-40)4-3-17-57-49(67)37-74-31-30-73-29-28-72-27-26-71-25-18-58-48(66)6-2-1-5-47-51-46(38-75-47)61-54(70)62-51/h7-14,32,34,45-47,51H,1-2,5-6,15-31,35-38H2,(H,57,67)(H,58,66)(H,60,68)(H2,61,62,70)/t46?,47-,51?/m0/s1	FWJRFHYFNIIOBV-FVWFCGMMSA-N	328021	N-(1-(4- cyanobenzyl)piperidin-4- yl)-3-(5,20-dioxo-24- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-7,10,13,16-tetraoxa- 4,19-diazatetracos-1- ynyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 159::US9663496, Compound 159	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328021&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486202	384582937							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816839	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1	InChI=1S/C32H35FN4O4/c1-41-28-9-2-22(3-10-28)21-36-16-14-27(15-17-36)35-31(39)29-11-6-25(20-34-29)32(40)37-18-12-24(13-19-37)30(38)23-4-7-26(33)8-5-23/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	KXKXMISUTNBPTD-UHFFFAOYSA-N	328022	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 160::US9663496, Compound 160	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328022&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710693	384582938							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816840	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C31H35FN4O4/c1-39-26-7-2-22(3-8-26)21-35-16-12-25(13-17-35)34-30(37)29-11-4-23(20-33-29)31(38)36-18-14-28(15-19-36)40-27-9-5-24(32)6-10-27/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	GQLHMTROMKDTKQ-UHFFFAOYSA-N	328023	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 161::US9663496, Compound 161	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328023&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710672	384582939							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816841	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-4-24(5-8-27)22-36-16-12-26(13-17-36)35-31(38)30-11-6-25(21-34-30)32(39)37-18-14-29(15-19-37)41-28-9-2-23(20-33)3-10-28/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	AAZRKTXOGFHLEO-UHFFFAOYSA-N	328024	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 162::US9663496, Compound 162	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328024&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710427	384582940							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816842	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C33H38N4O5/c1-41-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)30-12-7-26(21-34-30)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(42-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	DTAVECBCQBGUGF-UHFFFAOYSA-N	328025	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 163::US9663496, Compound 163	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328025&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710233	384582941							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816843	CC(C)(C)OC(=O)NCC#Cc1cc(cnc1C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C39H44FN7O4/c1-39(2,3)51-38(50)42-16-4-5-31-23-32(37(49)47-21-19-46(20-22-47)27-30-10-12-33(40)13-11-30)25-43-35(31)36(48)44-34-14-17-45(18-15-34)26-29-8-6-28(24-41)7-9-29/h6-13,23,25,34H,14-22,26-27H2,1-3H3,(H,42,50)(H,44,48)	MUQUTLCBPZXGBA-UHFFFAOYSA-N	328026	US10377742, Compound 164::US9663496, Compound 164::tert-butyl 3-(2-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-3- yl)prop-2-ynylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328026&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710606	384582942							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816844	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H32N6O2/c32-19-23-1-3-25(4-2-23)22-36-15-11-26(12-16-36)35-31(38)30-10-7-27(21-34-30)37-17-13-29(14-18-37)39-28-8-5-24(20-33)6-9-28/h1-10,21,26,29H,11-18,22H2,(H,35,38)	RMRAPVQTYURKPZ-UHFFFAOYSA-N	328027	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenoxy)piperidin- 1-yl)picolinamide::US10377742, Compound 165::US9663496, Compound 165	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328027&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710718	384582943							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816845	O=C(NC1CCN(CC1)c1ccc(cc1)C#N)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H33N7O2/c33-19-23-1-3-25(4-2-23)22-38-15-11-27(12-16-38)37-32(41)30-10-7-26(21-35-30)31(40)36-28-13-17-39(18-14-28)29-8-5-24(20-34)6-9-29/h1-10,21,27-28H,11-18,22H2,(H,36,40)(H,37,41)	PYLAIZRZOYDMDH-UHFFFAOYSA-N	328028	N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5 -(1-(4- cyanophenyl)piperidin- 4-yl)pyridine-2,5- dicarboxamide::US10377742, Compound 166::US9663496, Compound 166	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328028&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710367	384582944							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816846	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)40-28-15-17-36(18-16-28)31(38)22-3-14-29(34-20-22)30(37)35-24-6-12-27(13-7-24)39-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27+	BZCVQNXMJJLXPG-FEGDYQJNSA-N	328029	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 167::US9663496, Compound 167	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328029&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073475	384582945							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816847	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31FN4O4/c33-25-6-3-22(4-7-25)30(38)23-15-17-37(18-16-23)32(40)24-5-14-29(35-20-24)31(39)36-26-8-12-28(13-9-26)41-27-10-1-21(19-34)2-11-27/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,36,39)/t26-,28-	KILULKZXXSWNCI-FBSWEULCSA-N	328030	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 168::US9663496, Compound 168	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328030&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073275	384582946							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816848	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)40-28-15-17-36(18-16-28)31(38)22-3-14-29(34-20-22)30(37)35-24-6-12-27(13-7-24)39-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27-	BZCVQNXMJJLXPG-HNKWHGCMSA-N	328031	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 169::US9663496, Compound 169	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328031&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073475	384582947							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816849	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC(=O)c3ccc(cc3)-c3ccccc3)nc2)cc1	InChI=1S/C30H27FN4O2/c31-27-13-6-22(7-14-27)21-34-16-18-35(19-17-34)30(37)26-12-15-28(32-20-26)33-29(36)25-10-8-24(9-11-25)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,32,33,36)	RVMRUZKLKWZPBU-UHFFFAOYSA-N	328032	N-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2- yl)biphenyl-4- carboxamide::US10377742, Compound 170::US9663496, Compound 170	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328032&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710824	384582948							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816850	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N	InChI=1S/C33H34N4O5/c1-41-27-11-4-23(5-12-27)31(38)24-16-18-37(19-17-24)33(40)25-6-15-30(35-21-25)32(39)36-26-7-13-29(14-8-26)42-28-9-2-22(20-34)3-10-28/h2-6,9-12,15,21,24,26,29H,7-8,13-14,16-19H2,1H3,(H,36,39)/t26-,29+	DXFJCXIKMLXEJV-RWDNANMHSA-N	328033	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 171::US9663496, Compound 171	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328033&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710361	384582949							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816851	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O5/c1-39-25-11-13-28(14-12-25)41-29-16-18-36(19-17-29)32(38)23-4-15-30(34-21-23)31(37)35-24-5-9-27(10-6-24)40-26-7-2-22(20-33)3-8-26/h2-4,7-8,11-15,21,24,27,29H,5-6,9-10,16-19H2,1H3,(H,35,37)/t24-,27-	QVGHVUBOGYEDKB-HNKWHGCMSA-N	328034	N-((trans)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 172::US9663496, Compound 172	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328034&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710218	384582950							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816852	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(NC(=O)C3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1	InChI=1S/C31H32FN5O3/c32-26-6-8-27(9-7-26)40-28-13-17-37(18-14-28)31(39)25-5-10-29(34-20-25)35-30(38)24-11-15-36(16-12-24)21-23-3-1-22(19-33)2-4-23/h1-10,20,24,28H,11-18,21H2,(H,34,35,38)	DFUCFJIFUHTKNO-UHFFFAOYSA-N	328035	1-(4-cyanobenzyl)-N-(5- (4-(4-fluorophenoxy)  piperidine-1- carbonyl)pyridin-2- yl)piperidine-4- carboxamide::US10377742, Compound 173::US9663496, Compound 173	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328035&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710684	384582951							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816853	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O5/c1-39-25-11-13-28(14-12-25)41-29-16-18-36(19-17-29)32(38)23-4-15-30(34-21-23)31(37)35-24-5-9-27(10-6-24)40-26-7-2-22(20-33)3-8-26/h2-4,7-8,11-15,21,24,27,29H,5-6,9-10,16-19H2,1H3,(H,35,37)/t24-,27+	QVGHVUBOGYEDKB-FEGDYQJNSA-N	328036	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 174::US9663496, Compound 174	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328036&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710218	384582952							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816854	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(NC(=O)C2CCN(Cc3ccc(cc3)C#N)CC2)nc1	InChI=1S/C32H32FN5O3/c33-28-8-5-24(6-9-28)30(39)25-13-17-38(18-14-25)32(41)27-7-10-29(35-20-27)36-31(40)26-11-15-37(16-12-26)21-23-3-1-22(19-34)2-4-23/h1-10,20,25-26H,11-18,21H2,(H,35,36,40)	WOIPUWNMUQRRTL-UHFFFAOYSA-N	328037	1-(4-cyanobenzyl)-N-(5- (4-(4-fluorobenzoyl)  piperidine-1- carbonyl)pyridin-2- yl)piperidine-4- carboxamide::US10377742, Compound 175::US9663496, Compound 175	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328037&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710722	384582953							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816855	Fc1ccc(O[C@H]2CCN(C2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C30H29FN4O4/c31-22-4-10-25(11-5-22)39-27-15-16-35(19-27)30(37)21-3-14-28(33-18-21)29(36)34-23-6-12-26(13-7-23)38-24-8-1-20(17-32)2-9-24/h1-5,8-11,14,18,23,26-27H,6-7,12-13,15-16,19H2,(H,34,36)/t23-,26+,27-/m0/s1	RRLULESDYPQECY-RNJDCESWSA-N	328038	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-((S)-3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 176::US9663496, Compound 176	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328038&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073399	384582954							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816856	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC(=O)c3ccc(Oc4ccc(F)cc4)nc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-23-5-1-20(2-6-23)19-35-13-15-36(16-14-35)29(38)22-3-11-26(32-18-22)34-28(37)21-4-12-27(33-17-21)39-25-9-7-24(31)8-10-25/h1-12,17-18H,13-16,19H2,(H,32,34,37)	BQJTYBHKLFNTMP-UHFFFAOYSA-N	328039	N-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2-yl)- 6-(4-fluorophenoxy)  nicotinamide::US10377742, Compound 177::US9663496, Compound 177	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328039&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710821	384582955							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816857	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)25-6-11-29(34-20-25)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	HMMQLGQVAFWIOP-UHFFFAOYSA-N	328040	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 178::US9663496, Compound 178	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328040&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710494	384582956							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816858	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C31H32F4N4O3/c32-24-6-1-21(2-7-24)20-38-15-11-25(12-16-38)37-29(40)28-10-3-22(19-36-28)30(41)39-17-13-27(14-18-39)42-26-8-4-23(5-9-26)31(33,34)35/h1-10,19,25,27H,11-18,20H2,(H,37,40)	RVROKBCZVIZYLZ-UHFFFAOYSA-N	328041	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 179::US9663496, Compound 179	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328041&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710492	384582957							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816859	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C30H32F2N4O3/c31-23-4-1-21(2-5-23)20-35-15-11-25(12-16-35)34-29(37)28-10-3-22(19-33-28)30(38)36-17-13-27(14-18-36)39-26-8-6-24(32)7-9-26/h1-10,19,25,27H,11-18,20H2,(H,34,37)	YUSQDVWUKSSAEC-UHFFFAOYSA-N	328042	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 180::US9663496, Compound 180	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328042&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073378	384582958							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816860	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2)cc1	InChI=1S/C31H32F2N4O3/c32-25-6-1-21(2-7-25)20-36-15-13-27(14-16-36)35-30(39)28-10-5-24(19-34-28)31(40)37-17-11-23(12-18-37)29(38)22-3-8-26(33)9-4-22/h1-10,19,23,27H,11-18,20H2,(H,35,39)	MBOYAXNHBWUBSB-UHFFFAOYSA-N	328043	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 181::US9663496, Compound 181	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328043&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073166	384582959							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816861	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CC[C@@H](C2)Oc2ccc(F)cc2)cc1	InChI=1S/C29H30F2N4O3/c30-22-4-1-20(2-5-22)18-34-14-11-24(12-15-34)33-28(36)27-10-3-21(17-32-27)29(37)35-16-13-26(19-35)38-25-8-6-23(31)7-9-25/h1-10,17,24,26H,11-16,18-19H2,(H,33,36)/t26-/m0/s1	JZOSWLKELUSKPW-SANMLTNESA-N	328044	(S)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 182::US9663496, Compound 182	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328044&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073186	384582960							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816862	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O4/c1-39-26-7-9-27(10-8-26)40-28-14-18-36(19-15-28)31(38)23-4-11-29(33-20-23)30(37)34-25-12-16-35(17-13-25)21-22-2-5-24(32)6-3-22/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	WETBWPNUDSHYAH-UHFFFAOYSA-N	328045	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 183::US9663496, Compound 183	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328045&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710706	384582961							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816863	COc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(OC)cc3)cc2)cc1	InChI=1S/C33H31N3O6/c1-40-26-8-3-22(4-9-26)31(37)23-17-19-36(20-18-23)33(39)24-5-16-30(34-21-24)32(38)35-25-6-10-28(11-7-25)42-29-14-12-27(41-2)13-15-29/h3-16,21,23H,17-20H2,1-2H3,(H,35,38)	QJSNZYYRFPKWGV-UHFFFAOYSA-N	409158	5-(4-(4-methoxybenzoyl)piperidine-1- carbonyl)-N-((cis)-4-(4- methoxyphenoxy)cyclohexyl)picolinamide::US10377742, Compound 184	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409158&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300111	406790734							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816864	COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C32H34F3N3O5/c1-41-24-11-13-27(14-12-24)42-26-9-5-23(6-10-26)37-30(39)29-15-2-21(20-36-29)31(40)38-18-16-28(17-19-38)43-25-7-3-22(4-8-25)32(33,34)35/h2-4,7-8,11-15,20,23,26,28H,5-6,9-10,16-19H2,1H3,(H,37,39)/t23-,26+	QKTLBWHRMYOPPU-VJXHGUGDSA-N	328047	N-((cis)-4-(4- methoxyphenoxy)  cyclohexyl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 185::US9663496, Compound 185	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328047&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710373	384582963							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816865	COc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(OC)cc2)cc1	InChI=1S/C32H37N3O6/c1-38-24-8-12-27(13-9-24)40-26-6-4-23(5-7-26)34-31(36)30-16-3-22(21-33-30)32(37)35-19-17-29(18-20-35)41-28-14-10-25(39-2)11-15-28/h3,8-16,21,23,26,29H,4-7,17-20H2,1-2H3,(H,34,36)/t23-,26+	KNSGWXFUNINQIP-VJXHGUGDSA-N	328048	N-((cis)-4-(4- methoxyphenoxy)  cyclohexyl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 186::US9663496, Compound 186	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328048&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710576	384582964							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816866	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C29H30F4N4O2/c30-24-6-1-21(2-7-24)20-35-15-17-37(18-16-35)28(38)22-3-10-27(34-19-22)36-13-11-26(12-14-36)39-25-8-4-23(5-9-25)29(31,32)33/h1-10,19,26H,11-18,20H2	NLRIVKKELMUADS-UHFFFAOYSA-N	328049	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)pyridin-3- yl)methanone::US10377742, Compound 187::US9663496, Compound 187	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328049&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073149	384582965							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816867	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C29H30FN5O2/c30-25-6-1-23(2-7-25)21-33-15-17-35(18-16-33)29(36)24-5-10-28(32-20-24)34-13-11-27(12-14-34)37-26-8-3-22(19-31)4-9-26/h1-10,20,27H,11-18,21H2	BWGZBBSRFIGRTF-UHFFFAOYSA-N	328050	4-(1-(5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-2- yl)piperidin-4- yloxy)benzonitrile::US10377742, Compound 188::US9663496, Compound 188	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328050&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073251	384582966							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816868	COc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H33FN4O3/c1-38-27-9-4-23(5-10-27)29(36)24-12-14-34(15-13-24)28-11-6-25(20-32-28)30(37)35-18-16-33(17-19-35)21-22-2-7-26(31)8-3-22/h2-11,20,24H,12-19,21H2,1H3	CHWFYLUDMGYJQK-UHFFFAOYSA-N	328051	(4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4-(4- methoxybenzoyl)  piperidin-1-yl)pyridin-3- yl)methanone::US10377742, Compound 189::US9663496, Compound 189	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328051&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073269	384582967							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816869	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H31F3N4O4/c33-32(34,35)23-4-10-26(11-5-23)43-28-15-17-39(18-16-28)31(41)22-3-14-29(37-20-22)30(40)38-24-6-12-27(13-7-24)42-25-8-1-21(19-36)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,38,40)/t24-,27+	QMWAQWPUELAOOP-FEGDYQJNSA-N	328052	N-((cis)-4-(4- cyanophenoxy)  cyclohexyl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 190::US9663496, Compound 190	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328052&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710521	384582968							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816870	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C(F)(F)F)cc1	InChI=1S/C32H34F3N3O5/c1-41-24-11-13-27(14-12-24)43-28-16-18-38(19-17-28)31(40)21-2-15-29(36-20-21)30(39)37-23-5-9-26(10-6-23)42-25-7-3-22(4-8-25)32(33,34)35/h2-4,7-8,11-15,20,23,26,28H,5-6,9-10,16-19H2,1H3,(H,37,39)/t23-,26+	SHXRZVBBZQBCEM-VJXHGUGDSA-N	328053	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-((cis)-4-(4- (trifluoromethyl)  phenoxy)cyclohexyl)  picolinamide::US10377742, Compound 191::US9663496, Compound 191	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328053&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710288	384582969							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816871	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C(F)(F)F	InChI=1S/C33H34F3N3O5/c1-43-26-9-2-21(3-10-26)30(40)22-16-18-39(19-17-22)32(42)23-4-15-29(37-20-23)31(41)38-25-7-13-28(14-8-25)44-27-11-5-24(6-12-27)33(34,35)36/h2-6,9-12,15,20,22,25,28H,7-8,13-14,16-19H2,1H3,(H,38,41)/t25-,28+	SWQOOGAKPQTEBM-XBMBGIQASA-N	328054	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-((cis)-4-(4- (trifluoromethyl)  phenoxy)cyclohexyl)  picolinamide::US10377742, Compound 192::US9663496, Compound 192	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328054&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710578	384582970							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816872	FC(F)(F)c1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H31F3N4O4/c33-32(34,35)23-4-10-26(11-5-23)42-27-12-6-24(7-13-27)38-30(40)29-14-3-22(20-37-29)31(41)39-17-15-28(16-18-39)43-25-8-1-21(19-36)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,38,40)/t24-,27+	IJCLQUTZPNXGSE-FEGDYQJNSA-N	409167	5-(4-(4-cyanophenoxy)piperidine-1- carbonyl)-N-((cis)-4-(4- (trifluoromethyl)phenoxy)cyclohexyl) picolinamide::US10377742, Compound 193	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409167&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710678	406790743							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816873	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O4/c1-45-32-11-6-27(7-12-32)34(42)28-14-22-41(23-15-28)36(44)29-8-13-33(37-24-29)35(43)38-30-16-20-39(21-17-30)25-26-4-9-31(10-5-26)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	RHQBNIHWJYVFEX-UHFFFAOYSA-N	328056	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 194::US9663496, Compound 194	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328056&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710402	384582972							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816874	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O4/c1-43-30-9-11-31(12-10-30)44-32-16-22-40(23-17-32)35(42)27-6-13-33(36-24-27)34(41)37-28-14-20-38(21-15-28)25-26-4-7-29(8-5-26)39-18-2-3-19-39/h4-13,24,28,32H,2-3,14-23,25H2,1H3,(H,37,41)	LBWSKARKXNZTCX-UHFFFAOYSA-N	328057	5-(4-(4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 195::US9663496, Compound 195	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328057&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710415	384582973							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816875	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C34H40FN5O3/c35-27-6-10-30(11-7-27)43-31-15-21-40(22-16-31)34(42)26-5-12-32(36-23-26)33(41)37-28-13-19-38(20-14-28)24-25-3-8-29(9-4-25)39-17-1-2-18-39/h3-12,23,28,31H,1-2,13-22,24H2,(H,37,41)	ZLSKBKAXFNIQNY-UHFFFAOYSA-N	328058	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 196::US9663496, Compound 196	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328058&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073145	384582974							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816876	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O3/c36-23-26-5-10-31(11-6-26)44-32-15-21-41(22-16-32)35(43)28-7-12-33(37-24-28)34(42)38-29-13-19-39(20-14-29)25-27-3-8-30(9-4-27)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)	NPOOJORPIVLQMN-UHFFFAOYSA-N	328059	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 197::US9663496, Compound 197	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328059&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710541	384582975							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816877	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(C#N)c(F)c2)cc1	InChI=1S/C32H33FN4O5/c1-40-24-9-11-26(12-10-24)41-27-14-16-37(17-15-27)32(39)22-3-13-30(35-20-22)31(38)36-23-4-7-25(8-5-23)42-28-6-2-21(19-34)29(33)18-28/h2-3,6,9-13,18,20,23,25,27H,4-5,7-8,14-17H2,1H3,(H,36,38)/t23-,25+	ILMFTSMWOSIQRL-GUOBSTCESA-N	409172	N-((cis)-4-(4-cyano-3- fluorophenoxy)cyclohexyl)-5-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 198	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409172&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300177	406790748							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816878	Fc1cc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)ccc1C#N	InChI=1S/C32H30F4N4O4/c33-28-17-27(7-1-20(28)18-37)44-25-10-5-23(6-11-25)39-30(41)29-12-2-21(19-38-29)31(42)40-15-13-26(14-16-40)43-24-8-3-22(4-9-24)32(34,35)36/h1-4,7-9,12,17,19,23,25-26H,5-6,10-11,13-16H2,(H,39,41)/t23-,25+	FWSGCPSSGXJESZ-GUOBSTCESA-N	409173	N-((cis)-4-(4-cyano-3- fluorophenoxy)cyclohexyl)-5-(4-(4- (trifluoromethyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 199	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409173&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710844	406790749							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816879	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-11-26(12-16-36)35-30(38)29-10-5-24(20-34-29)31(39)37-17-13-28(14-18-37)40-27-8-3-22(19-33)4-9-27/h1-10,20,26,28H,11-18,21H2,(H,35,38)	FYYVQVLSHZEUEM-UHFFFAOYSA-N	328062	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 200::US9663496, Compound 200	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328062&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710558	384582978							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816880	NC(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN6O3/c32-26-8-3-23(4-9-26)21-37-15-17-38(18-16-37)31(41)25-7-10-28(34-19-25)30(40)35-27-11-13-36(14-12-27)20-22-1-5-24(6-2-22)29(33)39/h1-10,19,27H,11-18,20-21H2,(H2,33,39)(H,35,40)	KAGDFRKVOFDGOY-UHFFFAOYSA-N	328063	N-(1-(4- carbamoylbenzyl)  piperidin-4-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 201::US9663496, Compound 201	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328063&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073393	384582979							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816881	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(C)cc2)cc1	InChI=1S/C32H38N4O4/c1-23-3-8-28(9-4-23)40-29-15-19-36(20-16-29)32(38)25-7-12-30(33-21-25)31(37)34-26-13-17-35(18-14-26)22-24-5-10-27(39-2)11-6-24/h3-12,21,26,29H,13-20,22H2,1-2H3,(H,34,37)	RMZUHPQXWRXPOP-UHFFFAOYSA-N	409176	N-(1-(4-methoxybenzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 202	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409176&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073337	406790752							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816882	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O3/c1-21-2-5-27(6-3-21)40-28-10-14-37(15-11-28)31(39)23-4-7-29(34-19-23)30(38)35-26-8-12-36(13-9-26)20-22-16-24(32)18-25(33)17-22/h2-7,16-19,26,28H,8-15,20H2,1H3,(H,35,38)	HDGCNHRJTDVRSF-UHFFFAOYSA-N	328155	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(p- tolyloxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 293::US9663496, Compound 293	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328155&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073179	384583070							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816883	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C30H26FN5O5/c1-40-23-7-2-19(3-8-23)28(37)20-12-14-36(15-13-20)30(39)26-18-32-25(17-33-26)29(38)35-22-6-11-27(34-16-22)41-24-9-4-21(31)5-10-24/h2-11,16-18,20H,12-15H2,1H3,(H,35,38)	IOMURNIMMPXUFN-UHFFFAOYSA-N	328066	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 204::US9663496, Compound 204	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328066&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710398	384582982							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816884	Fc1ccc(Oc2ccc(NC(=O)c3cnc(cn3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C(F)(F)F)cn2)cc1	InChI=1S/C29H23F4N5O4/c30-19-3-8-22(9-4-19)42-26-10-5-20(15-36-26)37-27(39)24-16-35-25(17-34-24)28(40)38-13-11-23(12-14-38)41-21-6-1-18(2-7-21)29(31,32)33/h1-10,15-17,23H,11-14H2,(H,37,39)	FIRJMSDQQVUXBK-UHFFFAOYSA-N	328067	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 205::US9663496, Compound 205	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328067&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710284	384582983							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816885	Fc1ccc(Oc2ccc(NC(=O)c3cnc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C29H22F3N5O4/c30-18-1-5-21(6-2-18)41-26-8-4-20(14-35-26)36-28(39)24-15-34-25(16-33-24)29(40)37-11-9-17(10-12-37)27(38)22-7-3-19(31)13-23(22)32/h1-8,13-17H,9-12H2,(H,36,39)	NFXJMTPKKPWDFD-UHFFFAOYSA-N	328068	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)pyrazine-2- carboxamide::US10377742, Compound 206::US9663496, Compound 206	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328068&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073205	384582984							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816886	Cc1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H26FN5O4/c1-19-2-7-22(8-3-19)38-24-12-14-35(15-13-24)29(37)26-18-31-25(17-32-26)28(36)34-21-6-11-27(33-16-21)39-23-9-4-20(30)5-10-23/h2-11,16-18,24H,12-15H2,1H3,(H,34,36)	YYUWHTNNPRUOTQ-UHFFFAOYSA-N	409181	N-(6-(4-fluorophenoxy)pyridin-3-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)pyrazine-2-carboxamide::US10377742, Compound 207	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409181&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073298	406790757							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816887	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O3/c1-26-4-11-31(12-5-26)43-32-16-22-40(23-17-32)35(42)28-8-13-33(36-24-28)34(41)37-29-14-20-38(21-15-29)25-27-6-9-30(10-7-27)39-18-2-3-19-39/h4-13,24,29,32H,2-3,14-23,25H2,1H3,(H,37,41)	YFVGVTOBOITCSX-UHFFFAOYSA-N	409182	5-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)-N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4-yl)picolinamide::US10377742, Compound 208	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409182&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073155	406790758							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816888	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CC(C1)Oc1ccc(cc1)C#N	InChI=1S/C30H28N6O3/c31-15-21-1-3-23(4-2-21)18-35-13-11-25(12-14-35)34-29(37)28-10-7-24(17-33-28)30(38)36-19-27(20-36)39-26-8-5-22(16-32)6-9-26/h1-10,17,25,27H,11-14,18-20H2,(H,34,37)	WKWOWUPNJQOYOV-UHFFFAOYSA-N	328071	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)picolinamide::US10377742, Compound 209::US9663496, Compound 209	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328071&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710784	384582987							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816889	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CC(C3)Oc3ccc(cc3)C#N)cn2)cc1	InChI=1S/C28H20FN5O4/c29-20-4-9-23(10-5-20)38-26-12-6-21(15-32-26)33-27(35)25-11-3-19(14-31-25)28(36)34-16-24(17-34)37-22-7-1-18(13-30)2-8-22/h1-12,14-15,24H,16-17H2,(H,33,35)	JGBMPZMXPFSPDG-UHFFFAOYSA-N	328072	5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 210::US9663496, Compound 210	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328072&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651337	384582988							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816890	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-27-8-6-24(7-9-27)30(39)25-10-16-38(17-11-25)32(41)29-20-34-28(19-35-29)31(40)36-26-12-14-37(15-13-26)21-23-4-2-22(18-33)3-5-23/h2-9,19-20,25-26H,10-17,21H2,1H3,(H,36,40)	NPKHHIRWHYYJGW-UHFFFAOYSA-N	328073	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 211::US9663496, Compound 211	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328073&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651338	384582989							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816891	FC(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H31F3N6O3/c32-31(33,34)23-5-7-25(8-6-23)43-26-11-15-40(16-12-26)30(42)28-19-36-27(18-37-28)29(41)38-24-9-13-39(14-10-24)20-22-3-1-21(17-35)2-4-22/h1-8,18-19,24,26H,9-16,20H2,(H,38,41)	AFFMBBJVFRZUEW-UHFFFAOYSA-N	328074	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 212::US9663496, Compound 212	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328074&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710199	384582990							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816892	CS(=O)(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O5S/c1-44(42,43)26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)23-4-9-29(35-19-23)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	FXHBRSQJDSUPGH-UHFFFAOYSA-N	328075	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)benzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 213::US9663496, Compound 213	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328075&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710353	384582991							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816893	CS(=O)(=O)c1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O5S/c1-43(40,41)29-9-4-24(5-10-29)22-36-16-12-26(13-17-36)35-31(38)25-6-11-30(34-21-25)32(39)37-18-14-28(15-19-37)42-27-7-2-23(20-33)3-8-27/h2-11,21,26,28H,12-19,22H2,1H3,(H,35,38)	RQSXOONFDVZBCK-UHFFFAOYSA-N	328076	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)benzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 214::US9663496, Compound 214	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328076&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710469	384582992							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816894	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)S(C)(=O)=O)CC2)cc1	InChI=1S/C32H38N4O6S/c1-41-26-6-8-27(9-7-26)42-28-15-19-36(20-16-28)32(38)30-12-5-24(21-33-30)31(37)34-25-13-17-35(18-14-25)22-23-3-10-29(11-4-23)43(2,39)40/h3-12,21,25,28H,13-20,22H2,1-2H3,(H,34,37)	NVACMJIIIPZMMM-UHFFFAOYSA-N	409189	6-(4-(4-methoxybenzoyl)piperidine-1- carbonyl)-N-(1-(4- (methylsulfonyl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 215	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409189&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300164	406790765							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816895	CS(=O)(=O)Nc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H35F2N5O5S/c1-45(43,44)37-26-6-2-21(3-7-26)20-38-14-12-25(13-15-38)36-31(41)23-4-9-29(35-19-23)32(42)39-16-10-22(11-17-39)30(40)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25,37H,10-17,20H2,1H3,(H,36,41)	PLFKPSQUHVQKGD-UHFFFAOYSA-N	328078	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonamido)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 216::US9663496, Compound 216	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328078&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710643	384582994							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816896	CS(=O)(=O)Nc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H36N6O5S/c1-44(41,42)36-27-7-2-24(3-8-27)22-37-16-12-26(13-17-37)35-31(39)25-6-11-30(34-21-25)32(40)38-18-14-29(15-19-38)43-28-9-4-23(20-33)5-10-28/h2-11,21,26,29,36H,12-19,22H2,1H3,(H,35,39)	KHXARCSTRQBUHC-UHFFFAOYSA-N	328079	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonamido)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 217::US9663496, Compound 217	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328079&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56651339	384582995							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816897	Cc1ccc(OC2CCN(CC2)C(=O)c2cnc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O3/c1-22-2-8-26(9-3-22)40-27-12-16-37(17-13-27)31(39)29-20-33-28(19-34-29)30(38)35-25-10-14-36(15-11-25)21-24-6-4-23(18-32)5-7-24/h2-9,19-20,25,27H,10-17,21H2,1H3,(H,35,38)	HQFKPRNNDOUANQ-UHFFFAOYSA-N	409192	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)pyrazine-2-carboxamide::US10377742, Compound 218	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409192&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073462	406790768							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816898	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1cnc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C35H39N7O3/c36-21-25-3-5-26(6-4-25)24-40-17-13-29(14-18-40)39-34(44)31-22-38-32(23-37-31)35(45)42-19-11-28(12-20-42)33(43)27-7-9-30(10-8-27)41-15-1-2-16-41/h3-10,22-23,28-29H,1-2,11-20,24H2,(H,39,44)	HVWHBZWYBCRQOP-UHFFFAOYSA-N	328081	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 219::US9663496, Compound 219	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328081&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710464	384582997							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816899	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cnc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C36H42N8O3/c1-41-18-20-43(21-19-41)31-8-6-28(7-9-31)34(45)29-10-16-44(17-11-29)36(47)33-24-38-32(23-39-33)35(46)40-30-12-14-42(15-13-30)25-27-4-2-26(22-37)3-5-27/h2-9,23-24,29-30H,10-21,25H2,1H3,(H,40,46)	YFJQTHWORCUTFF-UHFFFAOYSA-N	328082	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)pyrazine-2- carboxamide::US10377742, Compound 220::US9663496, Compound 220	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328082&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710371	384582998							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816900	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O3/c1-23-2-8-26(9-3-23)31(39)27-12-18-38(19-13-27)33(41)30-11-10-28(21-35-30)32(40)36-29-14-16-37(17-15-29)22-25-6-4-24(20-34)5-7-25/h2-11,21,27,29H,12-19,22H2,1H3,(H,36,40)	KGDGVGWNVIEHQL-UHFFFAOYSA-N	409195	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 221	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409195&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676188	406790771							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816901	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O3/c1-22-2-6-24(7-3-22)30(38)25-12-18-37(19-13-25)32(40)29-11-8-26(20-34-29)31(39)35-28-14-16-36(17-15-28)21-23-4-9-27(33)10-5-23/h2-11,20,25,28H,12-19,21H2,1H3,(H,35,39)	ULVQTPRAEGEBBG-UHFFFAOYSA-N	409196	N-(1-(4-fluorobenzyl)piperidin-4-yl)-6-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 222	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409196&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676189	406790772							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816902	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(C)cc2)cc1	InChI=1S/C33H38N4O4/c1-23-3-7-25(8-4-23)31(38)26-13-19-37(20-14-26)33(40)30-12-9-27(21-34-30)32(39)35-28-15-17-36(18-16-28)22-24-5-10-29(41-2)11-6-24/h3-12,21,26,28H,13-20,22H2,1-2H3,(H,35,39)	NDAAPEZTNBMFSX-UHFFFAOYSA-N	409197	N-(1-(4-methoxybenzyl)piperidin-4-yl)-6- (4-(4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 223	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409197&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676190	406790773							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816903	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O4/c1-20-2-4-21(5-3-20)29(37)22-14-16-36(17-15-22)31(39)27-12-6-23(18-33-27)30(38)35-25-9-13-28(34-19-25)40-26-10-7-24(32)8-11-26/h2-13,18-19,22H,14-17H2,1H3,(H,35,38)	IMOHABWBRHBSLW-UHFFFAOYSA-N	409198	N-(6-(4-fluorophenoxy)pyridin-3-yl)-6-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 224	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409198&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676191	406790774							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816904	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O3/c1-22-2-6-24(7-3-22)30(38)25-12-18-37(19-13-25)32(40)26-8-11-29(34-20-26)31(39)35-28-14-16-36(17-15-28)21-23-4-9-27(33)10-5-23/h2-11,20,25,28H,12-19,21H2,1H3,(H,35,39)	LNDMBSSQDKPZBK-UHFFFAOYSA-N	409199	N-(1-(4-fluorobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 225	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409199&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073533	406790775							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816905	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O3/c1-22-2-9-27(10-3-22)39-28-14-18-36(19-15-28)31(38)24-6-11-29(33-20-24)30(37)34-26-12-16-35(17-13-26)21-23-4-7-25(32)8-5-23/h2-11,20,26,28H,12-19,21H2,1H3,(H,34,37)	UWFMRHLPQYNROO-UHFFFAOYSA-N	409200	N-(1-(4-fluorobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 226	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409200&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073210	406790776							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816906	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O3/c1-23-2-9-28(10-3-23)40-29-14-18-37(19-15-29)32(39)26-8-11-30(34-21-26)31(38)35-27-12-16-36(17-13-27)22-25-6-4-24(20-33)5-7-25/h2-11,21,27,29H,12-19,22H2,1H3,(H,35,38)	FRTBKUDRDRDNQH-UHFFFAOYSA-N	409201	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 227	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409201&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676192	406790777							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816907	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O3/c1-23-2-8-26(9-3-23)31(39)27-12-18-38(19-13-27)33(41)28-10-11-30(35-21-28)32(40)36-29-14-16-37(17-15-29)22-25-6-4-24(20-34)5-7-25/h2-11,21,27,29H,12-19,22H2,1H3,(H,36,40)	JHTZDDUIDJQPJL-UHFFFAOYSA-N	409202	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 228	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409202&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676193	406790778							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816908	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O3/c1-26-4-8-28(9-5-26)34(42)29-14-22-41(23-15-29)36(44)33-13-10-30(24-37-33)35(43)38-31-16-20-39(21-17-31)25-27-6-11-32(12-7-27)40-18-2-3-19-40/h4-13,24,29,31H,2-3,14-23,25H2,1H3,(H,38,43)	XYCNAKIYNYYVAN-UHFFFAOYSA-N	409203	6-(4-(4-(methylsulfonyl)benzoyl)piperidine- 1-carbonyl)-N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4-yl)nicotinamide::US10377742, Compound 229	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409203&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676194	406790779							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816909	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)N3CCCC3)CC2)cc1	InChI=1S/C35H43N5O3/c1-26-4-11-31(12-5-26)43-32-16-22-40(23-17-32)35(42)33-13-8-28(24-36-33)34(41)37-29-14-20-38(21-15-29)25-27-6-9-30(10-7-27)39-18-2-3-19-39/h4-13,24,29,32H,2-3,14-23,25H2,1H3,(H,37,41)	IFWMUAMJALGARH-UHFFFAOYSA-N	409204	6-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)-N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4-yl)nicotinamide::US10377742, Compound 230	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409204&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676195	406790780							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816910	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C30H27FN4O4/c1-20-2-8-24(9-3-20)38-26-14-16-35(17-15-26)30(37)21-4-12-27(32-18-21)29(36)34-23-7-13-28(33-19-23)39-25-10-5-22(31)6-11-25/h2-13,18-19,26H,14-17H2,1H3,(H,34,36)	BNYMQAJOSJXUFB-UHFFFAOYSA-N	409205	N-(6-(4-fluorophenoxy)pyridin-3-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 231	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409205&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073549	406790781							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816911	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O4/c1-20-2-4-21(5-3-20)29(37)22-14-16-36(17-15-22)31(39)23-6-12-27(33-18-23)30(38)35-25-9-13-28(34-19-25)40-26-10-7-24(32)8-11-26/h2-13,18-19,22H,14-17H2,1H3,(H,35,38)	KQQWQTMZKXZLSA-UHFFFAOYSA-N	409206	N-(6-(4-fluorophenoxy)pyridin-3-yl)-5-(4- (4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 232	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409206&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073507	406790782							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816912	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1	InChI=1S/C36H43N5O3/c1-26-4-8-28(9-5-26)34(42)29-14-22-41(23-15-29)36(44)30-10-13-33(37-24-30)35(43)38-31-16-20-39(21-17-31)25-27-6-11-32(12-7-27)40-18-2-3-19-40/h4-13,24,29,31H,2-3,14-23,25H2,1H3,(H,38,43)	KTLZAASEAJJCLM-UHFFFAOYSA-N	409207	5-(4-(4-(methylsulfonyl)benzoyl)piperidine- 1-carbonyl)-N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4-yl)picolinamide::US10377742, Compound 233	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409207&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073489	406790783							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816913	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(C)cc2)cc1	InChI=1S/C33H38N4O4/c1-23-3-7-25(8-4-23)31(38)26-13-19-37(20-14-26)33(40)27-9-12-30(34-21-27)32(39)35-28-15-17-36(18-16-28)22-24-5-10-29(41-2)11-6-24/h3-12,21,26,28H,13-20,22H2,1-2H3,(H,35,39)	KZZKCAHRHQVUET-UHFFFAOYSA-N	409208	N-(1-(4-methoxybenzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 234	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409208&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			89732604	406790784							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816914	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Cc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H29FN4O3/c1-21-2-11-27(12-3-21)39-28-14-16-36(17-15-28)31(38)29-13-6-23(19-34-29)30(37)35-26-10-9-25(33-20-26)18-22-4-7-24(32)8-5-22/h2-13,19-20,28H,14-18H2,1H3,(H,35,37)	HFCRTCMPAUPEJW-UHFFFAOYSA-N	409209	N-(6-(4-fluorophenoxy)pyridin-3-yl)-6-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 235	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409209&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676196	406790785							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816915	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O3/c1-21-2-5-27(6-3-21)40-28-10-14-37(15-11-28)31(39)29-7-4-23(19-34-29)30(38)35-26-8-12-36(13-9-26)20-22-16-24(32)18-25(33)17-22/h2-7,16-19,26,28H,8-15,20H2,1H3,(H,35,38)	XELPDCRJZXPXEC-UHFFFAOYSA-N	409210	N-(1-(3,5-difluorobenzyl)piperidin-4-yl)-6- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 236	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409210&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676197	406790786							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816916	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(C)cc2)cc1	InChI=1S/C32H38N4O4/c1-23-3-8-28(9-4-23)40-29-15-19-36(20-16-29)32(38)30-12-7-25(21-33-30)31(37)34-26-13-17-35(18-14-26)22-24-5-10-27(39-2)11-6-24/h3-12,21,26,29H,13-20,22H2,1-2H3,(H,34,37)	GNPZRGSPKYRVQL-UHFFFAOYSA-N	409211	N-(1-(4-methoxybenzyl)piperidin-4-yl)-6- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 237	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409211&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676198	406790787							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816917	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(C)cc2)c1	InChI=1S/C32H38N4O4/c1-23-6-9-27(10-7-23)40-28-14-18-36(19-15-28)32(38)30-11-8-25(21-33-30)31(37)34-26-12-16-35(17-13-26)22-24-4-3-5-29(20-24)39-2/h3-11,20-21,26,28H,12-19,22H2,1-2H3,(H,34,37)	SUIBOECFXUWNJD-UHFFFAOYSA-N	409212	N-(1-(3-methoxybenzyl)piperidin-4-yl)-6- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 238	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409212&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676199	406790788							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816918	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C32H35F3N4O4/c1-22-5-8-26(9-6-22)42-27-13-17-39(18-14-27)31(41)29-10-7-24(20-36-29)30(40)37-25-11-15-38(16-12-25)21-23-3-2-4-28(19-23)43-32(33,34)35/h2-10,19-20,25,27H,11-18,21H2,1H3,(H,37,40)	UEBVAJNVSYRMTO-UHFFFAOYSA-N	409213	6-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 239	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409213&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676200	406790789							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816919	[N-]=[N+]=Nc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H32N8O3/c33-19-22-1-3-23(4-2-22)21-39-15-13-27(14-16-39)36-31(42)26-7-10-29(35-20-26)32(43)40-17-11-25(12-18-40)30(41)24-5-8-28(9-6-24)37-38-34/h1-10,20,25,27H,11-18,21H2,(H,36,42)	PUIJFXMIHQEIKP-UHFFFAOYSA-N	328102	6-(4-(4- azidobenzoyl)piperidine- 1-carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 240::US9663496, Compound 240	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328102&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			89724914	384583018							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816920	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(C)cc2)c1	InChI=1S/C32H38N4O4/c1-23-6-9-27(10-7-23)40-28-14-18-36(19-15-28)32(38)25-8-11-30(33-21-25)31(37)34-26-12-16-35(17-13-26)22-24-4-3-5-29(20-24)39-2/h3-11,20-21,26,28H,12-19,22H2,1-2H3,(H,34,37)	LKRAGLNUAHXJNT-UHFFFAOYSA-N	409215	N-(1-(3-methoxybenzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 241	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409215&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676201	406790791							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816921	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C32H35F3N4O4/c1-22-5-8-26(9-6-22)42-27-13-17-39(18-14-27)31(41)24-7-10-29(36-20-24)30(40)37-25-11-15-38(16-12-25)21-23-3-2-4-28(19-23)43-32(33,34)35/h2-10,19-20,25,27H,11-18,21H2,1H3,(H,37,40)	NMFZGXPEWYDHKX-UHFFFAOYSA-N	409216	5-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 242	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409216&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676202	406790792							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816922	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C37H43N7O3/c1-41-20-22-43(23-21-41)33-9-6-29(7-10-33)35(45)30-12-18-44(19-13-30)37(47)34-11-8-31(25-39-34)36(46)40-32-14-16-42(17-15-32)26-28-4-2-27(24-38)3-5-28/h2-11,25,30,32H,12-23,26H2,1H3,(H,40,46)	DNOOJFBSTXDBIH-UHFFFAOYSA-N	328105	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 243::US9663496, Compound 243	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328105&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710526	384583021							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816923	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C37H43F3N6O4/c1-43-20-22-45(23-21-43)31-7-4-27(5-8-31)34(47)28-12-18-46(19-13-28)36(49)33-11-6-29(24-41-33)35(48)42-30-14-16-44(17-15-30)25-26-2-9-32(10-3-26)50-37(38,39)40/h2-11,24,28,30H,12-23,25H2,1H3,(H,42,48)	BSKIKGJMGXCCRR-UHFFFAOYSA-N	328106	6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 244::US9663496, Compound 244	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328106&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710318	384583022							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816924	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C35H35FN6O4/c1-40-18-20-41(21-19-40)29-8-2-24(3-9-29)33(43)25-14-16-42(17-15-25)35(45)31-12-4-26(22-37-31)34(44)39-28-7-13-32(38-23-28)46-30-10-5-27(36)6-11-30/h2-13,22-23,25H,14-21H2,1H3,(H,39,44)	CSSYEVQJDFHNJP-UHFFFAOYSA-N	328107	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 245::US9663496, Compound 245	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328107&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710727	384583023							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816925	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C34H37N5O5S/c35-21-24-1-3-25(4-2-24)23-38-17-13-27(14-18-38)37-33(40)26-5-12-32(36-22-26)34(41)39-19-15-29(16-20-39)44-28-6-8-30(9-7-28)45(42,43)31-10-11-31/h1-9,12,22,27,29,31H,10-11,13-20,23H2,(H,37,40)	CINVMDLCMBUCQO-UHFFFAOYSA-N	328108	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 246::US9663496, Compound 246	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328108&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710410	384583024							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816926	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(=O)(=O)C3CC3)cn2)cc1	InChI=1S/C32H29FN4O6S/c33-22-2-5-25(6-3-22)43-30-14-4-23(20-35-30)36-31(38)21-1-13-29(34-19-21)32(39)37-17-15-26(16-18-37)42-24-7-9-27(10-8-24)44(40,41)28-11-12-28/h1-10,13-14,19-20,26,28H,11-12,15-18H2,(H,36,38)	ZZWJDICOSBHOKT-UHFFFAOYSA-N	328109	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 247::US9663496, Compound 247	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328109&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710789	384583025							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816927	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C37H45N5O5S/c43-36(39-29-15-21-40(22-16-29)26-27-3-6-30(7-4-27)41-19-1-2-20-41)28-5-14-35(38-25-28)37(44)42-23-17-32(18-24-42)47-31-8-10-33(11-9-31)48(45,46)34-12-13-34/h3-11,14,25,29,32,34H,1-2,12-13,15-24,26H2,(H,39,43)	WTXNEQJNAQMKMM-UHFFFAOYSA-N	328110	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 248::US9663496, Compound 248	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328110&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710451	384583026							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816928	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(=O)(=O)C2CC2)cc1	InChI=1S/C34H37F3N4O6S/c35-34(36,37)47-28-4-1-23(2-5-28)22-40-17-13-25(14-18-40)39-32(42)24-3-12-31(38-21-24)33(43)41-19-15-27(16-20-41)46-26-6-8-29(9-7-26)48(44,45)30-10-11-30/h1-9,12,21,25,27,30H,10-11,13-20,22H2,(H,39,42)	LOCVLBUUUHGTAV-UHFFFAOYSA-N	328111	6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 249::US9663496, Compound 249	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328111&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710535	384583027							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816929	Cc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H34N6O2/c1-23-2-9-28(10-3-23)36-16-18-37(19-17-36)31(39)26-8-11-29(33-21-26)30(38)34-27-12-14-35(15-13-27)22-25-6-4-24(20-32)5-7-25/h2-11,21,27H,12-19,22H2,1H3,(H,34,38)	NIJAFYOANGVJPO-UHFFFAOYSA-N	409224	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(methylsulfonyl)phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 250	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409224&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676203	406790800							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816930	CC(C)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H38N6O2/c1-24(2)27-7-10-30(11-8-27)38-17-19-39(20-18-38)33(41)28-9-12-31(35-22-28)32(40)36-29-13-15-37(16-14-29)23-26-5-3-25(21-34)4-6-26/h3-12,22,24,29H,13-20,23H2,1-2H3,(H,36,40)	KHKOALZGRAJSFA-UHFFFAOYSA-N	409225	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(isopropylsulfonyl)phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 251	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409225&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676204	406790801							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816931	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O3/c1-22-2-8-25(9-3-22)31(40)26-12-16-39(17-13-26)33(42)27-10-11-30(36-19-27)32(41)37-29-14-15-38(21-28(29)34)20-24-6-4-23(18-35)5-7-24/h2-11,19,26,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m1/s1	WSHUFJLKIMPHGV-FQLXRVMXSA-N	409226	N-((trans)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-5-(4-(4- (methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 252	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409226&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676205	406790802							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816932	Cc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@H]1F	InChI=1S/C33H34F4N4O4/c1-21-2-6-23(7-3-21)30(42)24-12-16-41(17-13-24)32(44)25-8-11-29(38-18-25)31(43)39-28-14-15-40(20-27(28)34)19-22-4-9-26(10-5-22)45-33(35,36)37/h2-11,18,24,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28-/m1/s1	NTVPQQJMHXKAKS-VSGBNLITSA-N	409227	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)benzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 253	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409227&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676206	406790803							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816933	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(cc3)C#N)C[C@H]2F)cc1	InChI=1S/C32H34FN5O3/c1-22-2-9-26(10-3-22)41-27-12-16-38(17-13-27)32(40)25-8-11-30(35-19-25)31(39)36-29-14-15-37(21-28(29)33)20-24-6-4-23(18-34)5-7-24/h2-11,19,27-29H,12-17,20-21H2,1H3,(H,36,39)/t28-,29-/m1/s1	ODBQSZFTJYTYMN-FQLXRVMXSA-N	409228	N-((trans)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-5-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 254	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409228&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676207	406790804							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816934	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(OC(F)(F)F)cc3)C[C@H]2F)cc1	InChI=1S/C32H34F4N4O4/c1-21-2-7-24(8-3-21)43-25-12-16-40(17-13-25)31(42)23-6-11-29(37-18-23)30(41)38-28-14-15-39(20-27(28)33)19-22-4-9-26(10-5-22)44-32(34,35)36/h2-11,18,25,27-28H,12-17,19-20H2,1H3,(H,38,41)/t27-,28-/m1/s1	VKGSNVAHZGVOQI-VSGBNLITSA-N	409229	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)benzyl)piperidin-4-yl)-5- (4-(4-(methylsulfonyl)phenoxy)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 255	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409229&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676208	406790805							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816935	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)S(=O)(=O)C1CC1	InChI=1S/C33H36N6O4S/c34-21-24-1-3-25(4-2-24)23-37-15-13-27(14-16-37)36-32(40)31-12-5-26(22-35-31)33(41)39-19-17-38(18-20-39)28-6-8-29(9-7-28)44(42,43)30-10-11-30/h1-9,12,22,27,30H,10-11,13-20,23H2,(H,36,40)	CWUZNYCHXNYQDR-UHFFFAOYSA-N	328118	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (cyclopropylsulfonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 256::US9663496, Compound 256	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328118&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710418	384583034							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816936	FC(F)(F)S(=O)(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31F3N6O4S/c32-31(33,34)45(43,44)27-8-6-26(7-9-27)39-15-17-40(18-16-39)30(42)24-5-10-28(36-20-24)29(41)37-25-11-13-38(14-12-25)21-23-3-1-22(19-35)2-4-23/h1-10,20,25H,11-18,21H2,(H,37,41)	CIYOQUUILYLVDA-UHFFFAOYSA-N	328119	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylsulfonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 257::US9663496, Compound 257	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328119&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710255	384583035							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816937	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)C(=O)C1CC1	InChI=1S/C34H36N6O3/c35-21-24-1-3-25(4-2-24)23-38-15-13-29(14-16-38)37-33(42)31-12-9-28(22-36-31)34(43)40-19-17-39(18-20-40)30-10-7-27(8-11-30)32(41)26-5-6-26/h1-4,7-12,22,26,29H,5-6,13-20,23H2,(H,37,42)	SRJYEJPJELERDT-UHFFFAOYSA-N	328120	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (cyclopropanecarbonyl)  phenyl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 258::US9663496, Compound 258	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328120&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710311	384583036							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816938	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)Oc3ccc(C)cc3)cn2)cc1	InChI=1S/C32H30N4O5/c1-21-3-9-26(10-4-21)40-28-15-17-36(18-16-28)32(39)24-7-13-29(33-19-24)31(38)35-25-8-14-30(34-20-25)41-27-11-5-23(6-12-27)22(2)37/h3-14,19-20,28H,15-18H2,1-2H3,(H,35,38)	PJSJDTHVWVECNP-UHFFFAOYSA-N	409233	N-(6-(4-acetylphenoxy)pyridin-3-yl)-5-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 259	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409233&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676209	406790809							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816939	CCc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C34H37N5O3/c1-2-24-7-9-27(10-8-24)32(40)28-13-19-39(20-14-28)34(42)29-11-12-31(36-22-29)33(41)37-30-15-17-38(18-16-30)23-26-5-3-25(21-35)4-6-26/h3-12,22,28,30H,2,13-20,23H2,1H3,(H,37,41)	HHGYWGZUFUZIJY-UHFFFAOYSA-N	409234	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(ethylsulfonyl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 260	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409234&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676210	406790810							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816940	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(nc2)S(=O)(=O)c2ccc(F)cc2)cc1	InChI=1S/C30H27FN4O5S/c1-20-2-8-24(9-3-20)40-25-14-16-35(17-15-25)30(37)21-4-12-27(32-18-21)29(36)34-23-7-13-28(33-19-23)41(38,39)26-10-5-22(31)6-11-26/h2-13,18-19,25H,14-17H2,1H3,(H,34,36)	HRXDQFIBPTVVSO-UHFFFAOYSA-N	409235	N-(6-(4-fluorophenylsulfonyl)pyridin-3-yl)- 5-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 261	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409235&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676211	406790811							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816941	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32FN5O4S/c32-25-6-8-27(9-7-25)42(40,41)28-13-17-37(18-14-28)31(39)24-5-10-29(34-20-24)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-33)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,35,38)	WPGURWCGKIGDPP-UHFFFAOYSA-N	328124	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 262::US9663496, Compound 262	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328124&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710286	384583040							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816942	FC(F)(F)C(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F3N6O3/c33-32(34,35)29(42)24-5-8-27(9-6-24)40-15-17-41(18-16-40)31(44)25-7-10-28(37-20-25)30(43)38-26-11-13-39(14-12-26)21-23-3-1-22(19-36)2-4-23/h1-10,20,26H,11-18,21H2,(H,38,43)	RGJWOFQNRMIXJW-UHFFFAOYSA-N	328125	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(2,2,2- trifluoroacetyl)phenyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 263::US9663496, Compound 263	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328125&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710688	384583041							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816943	O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccccc2)CC1	InChI=1S/C31H37N5O2/c37-30(33-27-13-17-35(18-14-27)22-24-7-3-1-4-8-24)26-11-12-29(32-21-26)31(38)34-28-15-19-36(20-16-28)23-25-9-5-2-6-10-25/h1-12,21,27-28H,13-20,22-23H2,(H,33,37)(H,34,38)	GFDOYTAWIKLKSA-UHFFFAOYSA-N	328126	N2,N5-bis(1- benzylpiperidin-4- yl)pyridine-2,5- dicarboxamide::US10377742, Compound 264::US9663496, Compound 264	5'-AMP-activated protein kinase catalytic subunit alpha-2					 7500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328126&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710860	384583042							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816944	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)N1CCCC(C1)Oc1ccc(cc1)C#N	InChI=1S/C31H32N6O2/c32-18-23-3-5-25(6-4-23)21-36-16-13-26(14-17-36)35-31(38)30-12-9-27(20-34-30)37-15-1-2-29(22-37)39-28-10-7-24(19-33)8-11-28/h3-12,20,26,29H,1-2,13-17,21-22H2,(H,35,38)	PYKNAWSLPPFUNW-UHFFFAOYSA-N	328127	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- cyanophenoxy)piperidin- 1-yl)picolinamide::US10377742, Compound 265::US9663496, Compound 265	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328127&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710439	384583043							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816945	Clc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32ClN5O2/c32-26-7-5-24(6-8-26)30(38)25-11-17-37(18-12-25)28-9-10-29(34-20-28)31(39)35-27-13-15-36(16-14-27)21-23-3-1-22(19-33)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,35,39)	JVERBNBWKSQTRY-UHFFFAOYSA-N	328128	5-(4-(4- chlorobenzoyl)piperidin- 1-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 266::US9663496, Compound 266	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328128&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710328	384583044							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816946	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(NC2CCN(CC2)c2ccc(cc2)C#N)cn1	InChI=1S/C31H33N7O/c32-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-28(21-34-30)35-26-13-17-38(18-14-26)29-8-5-24(20-33)6-9-29/h1-10,21,26-27,35H,11-18,22H2,(H,36,39)	SXLNCLDXSZOPBZ-UHFFFAOYSA-N	328129	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- cyanophenyl)piperidin- 4-ylamino)picolinamide::US10377742, Compound 267::US9663496, Compound 267	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328129&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710270	384583045							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816947	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccncc1	InChI=1S/C30H32N6O3/c31-19-22-1-3-23(4-2-22)21-35-15-9-25(10-16-35)34-29(37)28-6-5-24(20-33-28)30(38)36-17-11-27(12-18-36)39-26-7-13-32-14-8-26/h1-8,13-14,20,25,27H,9-12,15-18,21H2,(H,34,37)	AHTSNSKNLLGNAL-UHFFFAOYSA-N	328130	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2-(4- fluorophenyl)propan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 269::US9663496, Compound 268::US9663496, Compound 269	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328130&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710848	384583046							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816948	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccncc1	InChI=1S/C30H32N6O3/c31-19-22-1-3-23(4-2-22)21-35-15-9-25(10-16-35)34-29(37)28-6-5-24(20-33-28)30(38)36-17-11-27(12-18-36)39-26-7-13-32-14-8-26/h1-8,13-14,20,25,27H,9-12,15-18,21H2,(H,34,37)	AHTSNSKNLLGNAL-UHFFFAOYSA-N	328130	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2-(4- fluorophenyl)propan-2- yl)piperazine-1- carbonyl)picolinamide::US10377742, Compound 269::US9663496, Compound 268::US9663496, Compound 269	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328130&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710848	384583046							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816949	Fc1ccc(OC2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-24-6-8-26(9-7-24)39-27-13-16-36(20-27)30(38)23-5-10-28(33-18-23)29(37)34-25-11-14-35(15-12-25)19-22-3-1-21(17-32)2-4-22/h1-10,18,25,27H,11-16,19-20H2,(H,34,37)	RLJZRJSNAZYVPY-UHFFFAOYSA-N	328132	(S)-N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 270::US9663496, Compound 270	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328132&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710414	384583047							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816950	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)24-5-8-29(36-19-24)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	XRDMDDSSWUSOAX-UHFFFAOYSA-N	328133	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 271::US9663496, Compound 271	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328133&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710298	384583048							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816951	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C30H24F2N4O4/c31-22-4-1-19(2-5-22)28(37)20-13-15-36(16-14-20)30(39)21-3-11-26(33-17-21)29(38)35-24-8-12-27(34-18-24)40-25-9-6-23(32)7-10-25/h1-12,17-18,20H,13-16H2,(H,35,38)	JLWLTWZTDHMFKR-UHFFFAOYSA-N	328134	5-(4-(4-fluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 272::US9663496, Compound 272	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328134&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710533	384583049							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816952	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H24F2N4O4/c30-20-2-7-23(8-3-20)38-25-13-15-35(16-14-25)29(37)19-1-11-26(32-17-19)28(36)34-22-6-12-27(33-18-22)39-24-9-4-21(31)5-10-24/h1-12,17-18,25H,13-16H2,(H,34,36)	CIXKEBBNLUBQNZ-UHFFFAOYSA-N	328135	5-(4-(4-fluorophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 273::US9663496, Compound 273	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328135&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710300	384583050							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816953	COc1ccc(OC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O4/c1-40-27-9-11-28(12-10-27)41-29-3-2-16-37(22-29)32(39)25-8-13-30(34-20-25)31(38)35-26-14-17-36(18-15-26)21-24-6-4-23(19-33)5-7-24/h4-13,20,26,29H,2-3,14-18,21-22H2,1H3,(H,35,38)	KFXYGIMFSTTWQR-UHFFFAOYSA-N	328136	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 274::US9663496, Compound 274	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328136&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710710	384583051							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816954	COc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H36N6O2/c1-39-29-9-7-28(8-10-29)37-18-14-25(15-19-37)34-27-6-11-30(33-21-27)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-32)3-5-24/h2-11,21,25-26,34H,12-19,22H2,1H3,(H,35,38)	KXVNZBABMIWAFP-UHFFFAOYSA-N	328137	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- methoxyphenyl)  piperidin-4- ylamino)picolinamide::US10377742, Compound 275::US9663496, Compound 275	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328137&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710448	384583052							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816955	Fc1ccc(cc1)N1CCC(CC1)Nc1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H33FN6O/c31-24-5-8-28(9-6-24)37-17-13-25(14-18-37)34-27-7-10-29(33-20-27)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,25-26,34H,11-18,21H2,(H,35,38)	WDIUOLAJMWXWDH-UHFFFAOYSA-N	328138	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(1-(4- fluorophenyl)piperidin- 4-ylamino)picolinamide::US10377742, Compound 276::US9663496, Compound 276	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328138&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710751	384583053							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816956	COc1cccc(OC2CCCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C32H35N5O4/c1-40-27-4-2-5-28(18-27)41-29-6-3-15-37(22-29)32(39)25-11-12-30(34-20-25)31(38)35-26-13-16-36(17-14-26)21-24-9-7-23(19-33)8-10-24/h2,4-5,7-12,18,20,26,29H,3,6,13-17,21-22H2,1H3,(H,35,38)	RSHRVHMHGAFLSZ-UHFFFAOYSA-N	328139	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(3- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 277::US9663496, Compound 277	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328139&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710461	384583054							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816957	Fc1ccc(O[C@@H]2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-24-6-8-26(9-7-24)39-27-13-16-36(20-27)30(38)23-5-10-28(33-18-23)29(37)34-25-11-14-35(15-12-25)19-22-3-1-21(17-32)2-4-22/h1-10,18,25,27H,11-16,19-20H2,(H,34,37)/t27-/m1/s1	RLJZRJSNAZYVPY-HHHXNRCGSA-N	328140	(R)-N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 278::US9663496, Compound 278	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328140&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652034	384583055							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816958	F[C@H]1CN(CC[C@@H]1Oc1ccc(cc1)C#N)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31FN6O3/c33-28-21-39(16-13-30(28)42-27-8-5-23(18-35)6-9-27)32(41)25-7-10-29(36-19-25)31(40)37-26-11-14-38(15-12-26)20-24-3-1-22(17-34)2-4-24/h1-10,19,26,28,30H,11-16,20-21H2,(H,37,40)/t28-,30-/m0/s1	ISSLZKSSYLRMSG-JDXGNMNLSA-N	328141	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-((trans)-4-(4- cyanophenoxy)-3- fluoropiperidine-1- carbonyl)picolinamide::US10377742, Compound 279::US9663496, Compound 279	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328141&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710441	384583056							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816959	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1C2CCC1CC(C2)Oc1ccc(cc1)C#N	InChI=1S/C34H34N6O3/c35-19-23-1-3-25(4-2-23)22-39-15-13-27(14-16-39)38-33(41)32-12-7-26(21-37-32)34(42)40-28-8-9-29(40)18-31(17-28)43-30-10-5-24(20-36)6-11-30/h1-7,10-12,21,27-29,31H,8-9,13-18,22H2,(H,38,41)	HVGKNJVYYFTFOB-UHFFFAOYSA-N	328142	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-((1R,3r,5S)-3-(4- cyanophenoxy)-8- azabicyclo[3.2.1]octane- 8-carbonyl)picolinamide::US10377742, Compound 280::US9663496, Compound 280	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328142&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			77175293	384583057							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816960	Fc1ccc(cc1F)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H31F2N5O3/c33-27-7-5-24(17-28(27)34)30(40)23-9-15-39(16-10-23)32(42)25-6-8-29(36-19-25)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	RVVFUTBGTJOJLC-UHFFFAOYSA-N	328143	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(3,4- difluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 281::US9663496, Compound 281	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328143&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710359	384583058							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816961	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C31H31F2N5O3/c32-24-6-8-29(27(33)17-24)41-26-11-15-38(16-12-26)31(40)23-5-7-28(35-19-23)30(39)36-25-9-13-37(14-10-25)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,25-26H,9-16,20H2,(H,36,39)	NTZCHZCFSJZAQG-UHFFFAOYSA-N	328144	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 282::US9663496, Compound 282	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328144&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710344	384583059							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816962	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1cccnc1	InChI=1S/C30H32N6O3/c31-18-22-3-5-23(6-4-22)21-35-14-9-25(10-15-35)34-29(37)28-8-7-24(19-33-28)30(38)36-16-11-26(12-17-36)39-27-2-1-13-32-20-27/h1-8,13,19-20,25-26H,9-12,14-17,21H2,(H,34,37)	WOYQNFWVHGYKBX-UHFFFAOYSA-N	328145	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(pyridin-3- yloxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 283::US9663496, Compound 283	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328145&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710446	384583060							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816963	CCOC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C34H37N5O5/c1-2-43-34(42)26-7-10-29(11-8-26)44-30-15-19-39(20-16-30)33(41)27-9-12-31(36-22-27)32(40)37-28-13-17-38(18-14-28)23-25-5-3-24(21-35)4-6-25/h3-12,22,28,30H,2,13-20,23H2,1H3,(H,37,40)	QBCOHMKIOZPEPA-UHFFFAOYSA-N	328146	US10377742, Compound 284::US9663496, Compound 284::ethyl 4-(1-(6-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)nicotinoyl)  piperidin-4- yloxy)benzoate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328146&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710564	384583061							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816964	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O3/c1-41-29-9-6-26(7-10-29)22-36-14-12-28(13-15-36)35-31(39)30-11-8-27(21-34-30)32(40)38-18-16-37(17-19-38)23-25-4-2-24(20-33)3-5-25/h2-11,21,28H,12-19,22-23H2,1H3,(H,35,39)	ZSDOZPPRAYGYEU-UHFFFAOYSA-N	328147	5-(4-(4- cyanobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 285::US9663496, Compound 285	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328147&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710495	384583062							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816965	COc1cc(ccc1OC1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C#N	InChI=1S/C32H34N6O3/c1-40-31-18-25(20-34)6-9-30(31)41-28-12-16-38(17-13-28)27-7-8-29(35-21-27)32(39)36-26-10-14-37(15-11-26)22-24-4-2-23(19-33)3-5-24/h2-9,18,21,26,28H,10-17,22H2,1H3,(H,36,39)	VHMVZBCHWOEJTQ-UHFFFAOYSA-N	328148	5-(4-(4-cyano-2- methoxyphenoxy)  piperidin-1-yl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 286::US9663496, Compound 286	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328148&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710506	384583063							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816966	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C32H34F2N4O4/c1-42-28-5-2-22(3-6-28)30(39)23-8-14-38(15-9-23)32(41)24-4-7-29(35-19-24)31(40)36-27-10-12-37(13-11-27)20-21-16-25(33)18-26(34)17-21/h2-7,16-19,23,27H,8-15,20H2,1H3,(H,36,40)	PQSYSUQLVSDROG-UHFFFAOYSA-N	328149	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 287::US9663496, Compound 287	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328149&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710486	384583064							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816967	Fc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C31H31F3N4O3/c32-24-4-1-21(2-5-24)29(39)22-7-13-38(14-8-22)31(41)23-3-6-28(35-18-23)30(40)36-27-9-11-37(12-10-27)19-20-15-25(33)17-26(34)16-20/h1-6,15-18,22,27H,7-14,19H2,(H,36,40)	RAFLQQGXFCLPCT-UHFFFAOYSA-N	328150	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 288::US9663496, Compound 288	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328150&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710815	384583065							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816968	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)c1	InChI=1S/C31H31F2N5O3/c32-24-15-22(16-25(33)17-24)20-37-11-7-26(8-12-37)36-30(39)29-6-3-23(19-35-29)31(40)38-13-9-28(10-14-38)41-27-4-1-21(18-34)2-5-27/h1-6,15-17,19,26,28H,7-14,20H2,(H,36,39)	SGEPABNOVNCCBC-UHFFFAOYSA-N	328151	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 289::US9663496, Compound 289	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328151&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710422	384583066							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816969	CC(C)(C)OC(=O)NCCCc1cc(cnc1C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C39H48FN7O4/c1-39(2,3)51-38(50)42-16-4-5-31-23-32(37(49)47-21-19-46(20-22-47)27-30-10-12-33(40)13-11-30)25-43-35(31)36(48)44-34-14-17-45(18-15-34)26-29-8-6-28(24-41)7-9-29/h6-13,23,25,34H,4-5,14-22,26-27H2,1-3H3,(H,42,50)(H,44,48)	HWTMPFJOXKCYBU-UHFFFAOYSA-N	328152	US10377742, Compound 290::US9663496, Compound 290::tert-butyl 3-(2-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)pyridin-3- yl)propylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328152&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710277	384583067							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816970	Fc1ccc(CN2CCN(CC2)C(=O)c2cnc(C(=O)NC3CCN(Cc4ccc(cc4)C#N)CC3)c(CCCNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]3SCC4NC(=O)NC34)c2)cc1	InChI=1S/C55H75FN10O9S/c56-45-13-11-42(12-14-45)38-65-22-24-66(25-23-65)54(70)44-34-43(51(60-36-44)53(69)61-46-15-20-64(21-16-46)37-41-9-7-40(35-57)8-10-41)4-3-18-58-50(68)17-26-72-28-30-74-32-33-75-31-29-73-27-19-59-49(67)6-2-1-5-48-52-47(39-76-48)62-55(71)63-52/h7-14,34,36,46-48,52H,1-6,15-33,37-39H2,(H,58,68)(H,59,67)(H,61,69)(H2,62,63,71)/t47?,48-,52?/m0/s1	WPSSXRQGFUCSRU-BUHZPHELSA-N	328153	N-(1-(4- cyanobenzyl)piperidin-4- yl)-3-(5,21-dioxo-25- ((3aS,4S,6aR)-2- oxohexahydro-lH- thieno[3,4-d]imidazol-4- yl)-8,11,14,17-tetraoxa- 4,20-diazapentacosyl)-5- (4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 291::US9663496, Compound 291	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328153&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			89737193	384583068							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816971	Fc1ccc(OC2CCN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C29H29F3N4O3/c30-21-2-4-25(5-3-21)39-26-9-12-36(18-26)29(38)20-1-6-27(33-16-20)28(37)34-24-7-10-35(11-8-24)17-19-13-22(31)15-23(32)14-19/h1-6,13-16,24,26H,7-12,17-18H2,(H,34,37)	ADMHSPDKZAALOS-UHFFFAOYSA-N	328154	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-((S)-3-(4- fluorophenoxy)  pyrrolidine-1- carbonyl)picolinamide::US10377742, Compound 292::US9663496, Compound 292	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328154&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710429	384583069							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816972	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O3/c1-21-2-5-27(6-3-21)40-28-10-14-37(15-11-28)31(39)23-4-7-29(34-19-23)30(38)35-26-8-12-36(13-9-26)20-22-16-24(32)18-25(33)17-22/h2-7,16-19,26,28H,8-15,20H2,1H3,(H,35,38)	HDGCNHRJTDVRSF-UHFFFAOYSA-N	328155	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(p- tolyloxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 293::US9663496, Compound 293	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328155&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073179	384583070							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816973	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(F)(F)F)c1	InChI=1S/C31H31F5N4O3/c32-23-15-20(16-24(33)17-23)19-39-11-7-25(8-12-39)38-29(41)28-6-1-21(18-37-28)30(42)40-13-9-27(10-14-40)43-26-4-2-22(3-5-26)31(34,35)36/h1-6,15-18,25,27H,7-14,19H2,(H,38,41)	APBUQRJICSRSSS-UHFFFAOYSA-N	328156	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 294::US9663496, Compound 294	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328156&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710472	384583071							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816974	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C30H31F3N4O3/c31-22-2-4-26(5-3-22)40-27-9-13-37(14-10-27)30(39)21-1-6-28(34-18-21)29(38)35-25-7-11-36(12-8-25)19-20-15-23(32)17-24(33)16-20/h1-6,15-18,25,27H,7-14,19H2,(H,35,38)	QPCNUSNHBFCPAM-UHFFFAOYSA-N	328157	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- fluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 295::US9663496, Compound 295	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328157&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710661	384583072							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816975	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C31H34F2N4O4/c1-40-26-3-5-27(6-4-26)41-28-10-14-37(15-11-28)31(39)22-2-7-29(34-19-22)30(38)35-25-8-12-36(13-9-25)20-21-16-23(32)18-24(33)17-21/h2-7,16-19,25,28H,8-15,20H2,1H3,(H,35,38)	HIVGHAUHDXNYQB-UHFFFAOYSA-N	328158	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(4- methoxyphenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 296::US9663496, Compound 296	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328158&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710188	384583073							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816976	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)c(F)c2)c1	InChI=1S/C30H30F4N4O3/c31-21-13-19(14-22(32)15-21)18-37-9-5-23(6-10-37)36-29(39)28-4-1-20(17-35-28)30(40)38-11-7-24(8-12-38)41-25-2-3-26(33)27(34)16-25/h1-4,13-17,23-24H,5-12,18H2,(H,36,39)	DTDPXJTYCFTEEW-UHFFFAOYSA-N	328159	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(4-(3,4- difluorophenoxy)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 297::US9663496, Compound 297	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328159&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710719	384583074							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816977	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)c(F)c2)c1	InChI=1S/C31H30F4N4O3/c32-23-13-19(14-24(33)16-23)18-38-9-7-25(8-10-38)37-30(41)28-4-2-22(17-36-28)31(42)39-11-5-20(6-12-39)29(40)21-1-3-26(34)27(35)15-21/h1-4,13-17,20,25H,5-12,18H2,(H,37,41)	DLBGZVFJKSQFKW-UHFFFAOYSA-N	328160	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 298::US9663496, Compound 298	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328160&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710420	384583075							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816978	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@H]2CC[C@H](CC2)Oc2cc(F)cc(F)c2)cc1	InChI=1S/C30H30F3N3O4/c31-20-2-6-24(7-3-20)39-26-11-13-36(14-12-26)30(38)19-1-10-28(34-18-19)29(37)35-23-4-8-25(9-5-23)40-27-16-21(32)15-22(33)17-27/h1-3,6-7,10,15-18,23,25-26H,4-5,8-9,11-14H2,(H,35,37)/t23-,25+	WBQCMGADTQIKRW-GUOBSTCESA-N	409273	N-((cis)-4-(3,5- difluorophenoxy)cyclohexyl)-5-(4-(4- fluorophenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 299	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409273	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409273&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710703	406790849							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816979	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1cc(F)cc(F)c1	InChI=1S/C32H33F2N3O5/c1-41-26-7-2-20(3-8-26)30(38)21-12-14-37(15-13-21)32(40)22-4-11-29(35-19-22)31(39)36-25-5-9-27(10-6-25)42-28-17-23(33)16-24(34)18-28/h2-4,7-8,11,16-19,21,25,27H,5-6,9-10,12-15H2,1H3,(H,36,39)/t25-,27+	WUUYOPINRPLTPV-LDNJAJMQSA-N	409274	N-((cis)-4-(3,5- difluorophenoxy)cyclohexyl)-5-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 300	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409274	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409274&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710704	406790850							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816980	FC(F)(F)c1ccc(OC2CCN(CC2)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F3N5O2/c32-31(33,34)24-5-8-27(9-6-24)41-28-13-17-39(18-14-28)26-7-10-29(36-20-26)30(40)37-25-11-15-38(16-12-25)21-23-3-1-22(19-35)2-4-23/h1-10,20,25,28H,11-18,21H2,(H,37,40)	JHRNQZYMFIIVGE-UHFFFAOYSA-N	328163	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)picolinamide::US10377742, Compound 301::US9663496, Compound 301	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328163&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710654	384583078							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816981	COc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H35N5O3/c1-40-29-9-6-25(7-10-29)31(38)26-12-18-37(19-13-26)28-8-11-30(34-21-28)32(39)35-27-14-16-36(17-15-27)22-24-4-2-23(20-33)3-5-24/h2-11,21,26-27H,12-19,22H2,1H3,(H,35,39)	HVAFECNXPDQFSX-UHFFFAOYSA-N	328164	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- methoxybenzoyl)  piperidin-1- yl)picolinamide::US10377742, Compound 302::US9663496, Compound 302	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328164&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710614	384583079							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816982	Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)39-27-12-6-24(7-13-27)35-30(37)29-14-3-22(20-34-29)31(38)36-17-15-28(16-18-36)40-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27+	XZNBTHWUHWCAHY-FEGDYQJNSA-N	409277	5-(4-(4-cyanophenoxy)piperidine-1- carbonyl)-N-((cis)-4-(4- fluorophenoxy)cyclohexyl)picolinamide::US10377742, Compound 303	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409277&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710712	406790853							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816983	Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)C#N)cc1	InChI=1S/C32H31FN4O4/c33-25-6-10-27(11-7-25)41-28-12-8-26(9-13-28)36-31(39)29-14-5-24(20-35-29)32(40)37-17-15-23(16-18-37)30(38)22-3-1-21(19-34)2-4-22/h1-7,10-11,14,20,23,26,28H,8-9,12-13,15-18H2,(H,36,39)/t26-,28+	KESKUMQAYVXYTP-DBAYTGFXSA-N	409278	5-(4-(4-fluorobenzoyl)piperidine-1- carbonyl)-N-((cis)-4-(4- fluorophenoxy)cyclohexyl)picolinamide::US10377742, Compound 304	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409278&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300167	406790854							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816984	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NCCOc1ccc(F)cc1	InChI=1S/C28H28FN3O5/c1-36-23-7-2-19(3-8-23)26(33)20-12-15-32(16-13-20)28(35)21-4-11-25(31-18-21)27(34)30-14-17-37-24-9-5-22(29)6-10-24/h2-11,18,20H,12-17H2,1H3,(H,30,34)	MLGAAABCCVIOEF-UHFFFAOYSA-N	328167	N-(2-(4- fluorophenoxy)ethyl)-5- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 305::US9663496, Compound 305	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328167&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710253	384583082							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816985	Fc1ccc(OCCNC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C27H25FN4O4/c28-21-4-8-22(9-5-21)35-16-13-30-26(33)25-10-3-20(18-31-25)27(34)32-14-11-24(12-15-32)36-23-6-1-19(17-29)2-7-23/h1-10,18,24H,11-16H2,(H,30,33)	ZSPDVYPDGBHLED-UHFFFAOYSA-N	328168	5-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(2-(4- fluorophenoxy)ethyl)  picolinamide::US10377742, Compound 306::US9663496, Compound 306	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328168&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710370	384583083							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816986	Fc1ccc(COC2CN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H30FN5O3/c31-25-8-5-23(6-9-25)20-39-27-18-36(19-27)30(38)24-7-10-28(33-16-24)29(37)34-26-11-13-35(14-12-26)17-22-3-1-21(15-32)2-4-22/h1-10,16,26-27H,11-14,17-20H2,(H,34,37)	JUPFXDZHGLSJJR-UHFFFAOYSA-N	328169	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(3-(4- fluorobenzyloxy)  azetidine-1- carbonyl)picolinamide::US10377742, Compound 307::US9663496, Compound 307	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328169&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710407	384583084							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816987	Fc1ccc(COC2CN(C2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3cc(F)cc(F)c3)CC2)cc1	InChI=1S/C29H29F3N4O3/c30-22-4-1-19(2-5-22)18-39-26-16-36(17-26)29(38)21-3-6-27(33-14-21)28(37)34-25-7-9-35(10-8-25)15-20-11-23(31)13-24(32)12-20/h1-6,11-14,25-26H,7-10,15-18H2,(H,34,37)	JTXPMIJNGKYFRZ-UHFFFAOYSA-N	328170	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-5-(3-(4- fluorobenzyloxy)  azetidine-1- carbonyl)picolinamide::US10377742, Compound 308::US9663496, Compound 308	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328170&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710575	384583085							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816988	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)30-11-8-27(21-35-30)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	JKGJLUCJLNJXKG-UHFFFAOYSA-N	328171	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 309::US9663496, Compound 309	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328171&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710293	384583086							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816989	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cc(F)cc(F)c2)CC1	InChI=1S/C32H34F2N4O4/c1-42-28-5-2-22(3-6-28)30(39)23-8-14-38(15-9-23)32(41)29-7-4-24(19-35-29)31(40)36-27-10-12-37(13-11-27)20-21-16-25(33)18-26(34)17-21/h2-7,16-19,23,27H,8-15,20H2,1H3,(H,36,40)	HFGMPLDTNKSDKF-UHFFFAOYSA-N	328172	N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 310::US9663496, Compound 310	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328172&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710633	384583087							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816990	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(F)cc1	InChI=1S/C32H34FN3O5/c1-40-26-9-2-21(3-10-26)30(37)22-16-18-36(19-17-22)32(39)23-4-15-29(34-20-23)31(38)35-25-7-13-28(14-8-25)41-27-11-5-24(33)6-12-27/h2-6,9-12,15,20,22,25,28H,7-8,13-14,16-19H2,1H3,(H,35,38)/t25-,28+	DDIKEHGCFSSELH-XBMBGIQASA-N	409285	N-((cis)-4-(4-fluorophenoxy)cyclohexyl)-5- (4-(4-methoxybenzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 311	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409285&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710582	406790861							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816991	Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2)cc1	InChI=1S/C30H31F2N3O4/c31-21-2-8-24(9-3-21)38-26-12-6-23(7-13-26)34-29(36)28-14-1-20(19-33-28)30(37)35-17-15-27(16-18-35)39-25-10-4-22(32)5-11-25/h1-5,8-11,14,19,23,26-27H,6-7,12-13,15-18H2,(H,34,36)/t23-,26+	VGTANERTDXIGKZ-VJXHGUGDSA-N	409286	N-((cis)-4-(4-fluorophenoxy)cyclohexyl)-5- (4-(4-fluorophenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 312	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409286&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710648	406790862							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816992	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CC(C2)Oc2ccc(cc2)C#N)c1	InChI=1S/C29H27F2N5O3/c30-22-11-20(12-23(31)13-22)16-35-9-7-24(8-10-35)34-28(37)27-6-3-21(15-33-27)29(38)36-17-26(18-36)39-25-4-1-19(14-32)2-5-25/h1-6,11-13,15,24,26H,7-10,16-18H2,(H,34,37)	OALQOHPDGYLZQW-UHFFFAOYSA-N	328175	5-(3-(4- cyanophenoxy)azetidine- 1-carbonyl)-N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 313::US9663496, Compound 313	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328175&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710675	384583090							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816993	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCn3c(C2)nnc3-c2ccc(cc2)C#N)c1	InChI=1S/C31H28F2N8O2/c32-24-13-21(14-25(33)15-24)18-39-9-7-26(8-10-39)36-30(42)27-6-5-23(17-35-27)31(43)40-11-12-41-28(19-40)37-38-29(41)22-3-1-20(16-34)2-4-22/h1-6,13-15,17,26H,7-12,18-19H2,(H,36,42)	BYINZUBHGSJUSR-UHFFFAOYSA-N	328176	5-(3-(4-cyanophenyl)- 5,6,7,8-tetrahydro- [1,2,4]triazolo[4,3- a]pyrazine-7-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)picolinamide::US10377742, Compound 314::US9663496, Compound 314	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328176&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710319	384583091							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816994	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H33N5O5/c1-41-27-9-4-23(5-10-27)30(38)24-12-16-36(17-13-24)32(40)29-11-6-25(21-34-29)31(39)35-26-14-18-37(19-15-26)42-28-7-2-22(20-33)3-8-28/h2-11,21,24,26H,12-19H2,1H3,(H,35,39)	CGHXVKSEPXSOKT-UHFFFAOYSA-N	409289	N-((1s,4s)-4-(4-cyanophenoxy)cyclohexyl)- 6-(4-(4-methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 315	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409289	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409289&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300114	406790865							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816995	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(CC1)Oc1ccc(F)cc1	InChI=1S/C31H33FN4O5/c1-40-26-7-2-21(3-8-26)29(37)22-12-16-35(17-13-22)31(39)28-11-4-23(20-33-28)30(38)34-25-14-18-36(19-15-25)41-27-9-5-24(32)6-10-27/h2-11,20,22,25H,12-19H2,1H3,(H,34,38)	PBWMNTCCVDFBFE-UHFFFAOYSA-N	409290	N-((cis)-4-(4-fluorophenoxy)cyclohexyl)-6- (4-(4-methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 316	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409290&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300131	406790866							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816996	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C32H35FN4O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)29-11-6-25(20-34-29)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21H2,1H3,(H,35,39)	KNIWBJVPMSYDST-UHFFFAOYSA-N	328179	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 317::US9663496, Compound 317	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328179&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710269	384583094							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816997	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C33H38N4O5/c1-41-28-8-3-23(4-9-28)22-36-17-15-27(16-18-36)35-32(39)26-7-12-30(34-21-26)33(40)37-19-13-25(14-20-37)31(38)24-5-10-29(42-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3,(H,35,39)	XGFSPOXBSRLZDO-UHFFFAOYSA-N	328180	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 318::US9663496, Compound 318	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328180&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710519	384583095							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816998	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H35N5O4/c1-40-27-7-4-24(5-8-27)22-36-16-12-26(13-17-36)35-31(38)25-6-11-30(34-21-25)32(39)37-18-14-29(15-19-37)41-28-9-2-23(20-33)3-10-28/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	KBPBPTZMSUNTBK-UHFFFAOYSA-N	328181	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 319::US9663496, Compound 319	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328181&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710665	384583096							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
816999	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-11-26(12-16-36)35-30(38)24-5-10-29(34-20-24)31(39)37-17-13-28(14-18-37)40-27-8-3-22(19-33)4-9-27/h1-10,20,26,28H,11-18,21H2,(H,35,38)	CJNVQFBBNTVLGQ-UHFFFAOYSA-N	328182	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 320::US9663496, Compound 320	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328182&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710562	384583097							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817000	O=C(N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H31N5O4/c33-19-22-1-8-26(9-2-22)40-28-12-6-25(7-13-28)36-31(38)24-5-14-30(35-21-24)32(39)37-17-15-29(16-18-37)41-27-10-3-23(20-34)4-11-27/h1-5,8-11,14,21,25,28-29H,6-7,12-13,15-18H2,(H,36,38)/t25-,28+	QXYDKUCICQMFKB-XBMBGIQASA-N	409295	N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(4-cyanophenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 321	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409295&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710423	406790871							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817001	Fc1cc(F)cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)c1	InChI=1S/C31H31F2N5O3/c32-24-15-22(16-25(33)17-24)20-37-11-7-26(8-12-37)36-30(39)23-3-6-29(35-19-23)31(40)38-13-9-28(10-14-38)41-27-4-1-21(18-34)2-5-27/h1-6,15-17,19,26,28H,7-14,20H2,(H,36,39)	DVERKLBRNMUJHI-UHFFFAOYSA-N	328184	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(3,5- difluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 322::US9663496, Compound 322	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328184&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710490	384583099							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817002	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)26-7-10-30(35-21-26)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)	ZXOKHOODFVNZIC-UHFFFAOYSA-N	328185	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 323::US9663496, Compound 323	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328185&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710645	384583100							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817003	Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H31FN4O4/c32-23-4-10-26(11-5-23)39-27-12-6-24(7-13-27)35-30(37)22-3-14-29(34-20-22)31(38)36-17-15-28(16-18-36)40-25-8-1-21(19-33)2-9-25/h1-5,8-11,14,20,24,27-28H,6-7,12-13,15-18H2,(H,35,37)/t24-,27+	ODCYZWPLGOHHLR-FEGDYQJNSA-N	409298	6-(4-(4-cyanophenoxy)piperidine-1- carbonyl)-N-((cis)-4-(4- fluorophenoxy)cyclohexyl)nicotinamide::US10377742, Compound 324	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409298&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710505	406790874							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817004	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(F)cc2)nc1	InChI=1S/C31H27FN4O5/c1-40-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)27-12-4-22(18-33-27)30(38)35-24-7-13-28(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	XYFIPKRIPGHVQF-UHFFFAOYSA-N	328187	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 325::US9663496, Compound 325	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328187&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710529	384583102							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817005	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C#N)cn2)cc1	InChI=1S/C30H24FN5O4/c31-22-4-9-25(10-5-22)40-28-12-6-23(19-34-28)35-29(37)21-3-11-27(33-18-21)30(38)36-15-13-26(14-16-36)39-24-7-1-20(17-32)2-8-24/h1-12,18-19,26H,13-16H2,(H,35,37)	XSUNUTFPDUBUTM-UHFFFAOYSA-N	328188	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 326::US9663496, Compound 326	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328188&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710283	384583103							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817006	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H36FN5O3/c1-40-28-9-4-24(5-10-28)21-35-14-12-27(13-15-35)34-30(38)25-6-11-29(33-20-25)31(39)37-18-16-36(17-19-37)22-23-2-7-26(32)8-3-23/h2-11,20,27H,12-19,21-22H2,1H3,(H,34,38)	OUYBMULCCUWUIY-UHFFFAOYSA-N	328189	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 327::US9663496, Compound 327	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328189&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710301	384583104							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817007	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C30H33F2N5O2/c31-25-6-1-22(2-7-25)20-35-13-11-27(12-14-35)34-29(38)24-5-10-28(33-19-24)30(39)37-17-15-36(16-18-37)21-23-3-8-26(32)9-4-23/h1-10,19,27H,11-18,20-21H2,(H,34,38)	JKAJRLZIQKBLFQ-UHFFFAOYSA-N	328190	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 328::US9663496, Compound 328	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328190&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710463	384583105							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817008	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)c(F)c2)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)29-9-5-24(19-35-29)32(41)38-16-10-22(11-17-38)30(39)23-4-8-27(33)28(34)18-23/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	NJOONPNZPKPCKC-UHFFFAOYSA-N	328191	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 329::US9663496, Compound 329	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328191&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710605	384583106							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817009	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)c(F)c3)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-21-3-6-23(7-4-21)41-27-10-5-22(17-35-27)36-29(39)26-9-2-20(16-34-26)30(40)37-13-11-18(12-14-37)28(38)19-1-8-24(32)25(33)15-19/h1-10,15-18H,11-14H2,(H,36,39)	RNONESCEJJROHR-UHFFFAOYSA-N	328192	5-(4-(3,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 330::US9663496, Compound 330	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328192&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710435	384583107							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817010	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(cn2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)29-9-4-23(19-35-29)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	MYYQGOANVIXKIS-UHFFFAOYSA-N	328193	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)picolinamide::US10377742, Compound 331::US9663496, Compound 331	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328193&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710337	384583108							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817011	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C31H32FN5O3/c32-25-6-1-23(2-7-25)21-36-15-17-37(18-16-36)31(39)29-14-5-24(20-34-29)30(38)35-26-8-12-28(13-9-26)40-27-10-3-22(19-33)4-11-27/h1-7,10-11,14,20,26,28H,8-9,12-13,15-18,21H2,(H,35,38)/t26-,28+	QMTWAPVKHUNKFZ-DBAYTGFXSA-N	409306	N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(4-fluorobenzyl)piperazine-1- carbonyl)nicotinamide::US10377742, Compound 332	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409306&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710663	406790882							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817012	CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C29H35N5O5/c1-29(2,3)39-28(37)34-14-10-22(11-15-34)32-26(35)21-6-9-25(31-19-21)27(36)33-16-12-24(13-17-33)38-23-7-4-20(18-30)5-8-23/h4-9,19,22,24H,10-17H2,1-3H3,(H,32,35)	BJGOHBYNVRHYBW-UHFFFAOYSA-N	328195	US10377742, Compound 333::US9663496, Compound 333::tert-butyl 4-(6-(4-(4- cyanophenoxy)  piperidine-1- carbonyl)nicotinamido)  piperidine-1-carboxylate	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328195&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710352	384583110							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817013	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C29H25F2N5O3/c30-22-4-1-20(2-5-22)19-35-13-15-36(16-14-35)29(38)26-11-3-21(17-32-26)28(37)34-24-8-12-27(33-18-24)39-25-9-6-23(31)7-10-25/h1-12,17-18H,13-16,19H2,(H,34,37)	HOYLOGISDOAXOM-UHFFFAOYSA-N	328196	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 334::US9663496, Compound 334	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328196&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710607	384583111							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817014	O=C(NC1CCNCC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C24H27N5O3/c25-15-17-1-4-20(5-2-17)32-21-9-13-29(14-10-21)24(31)22-6-3-18(16-27-22)23(30)28-19-7-11-26-12-8-19/h1-6,16,19,21,26H,7-14H2,(H,28,30)	QLERZABOMGLECS-UHFFFAOYSA-N	328197	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(piperidin-4- yl)nicotinamide::US10377742, Compound 335::US9663496, Compound 335	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328197&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710756	384583112							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817015	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O3/c36-23-26-5-10-31(11-6-26)44-32-15-21-41(22-16-32)35(43)33-12-7-28(24-37-33)34(42)38-29-13-19-39(20-14-29)25-27-3-8-30(9-4-27)40-17-1-2-18-40/h3-12,24,29,32H,1-2,13-22,25H2,(H,38,42)	ZWSIGMIBWASNND-UHFFFAOYSA-N	328198	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 336::US9663496, Compound 336	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328198&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710563	384583113							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817016	O=C(NC1CCN(Cc2ccc(cc2)N2CCOCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C35H40N6O4/c36-23-26-3-8-31(9-4-26)45-32-13-17-41(18-14-32)35(43)33-10-5-28(24-37-33)34(42)38-29-11-15-39(16-12-29)25-27-1-6-30(7-2-27)40-19-21-44-22-20-40/h1-10,24,29,32H,11-22,25H2,(H,38,42)	FKPBNJOZUYPWPE-UHFFFAOYSA-N	328199	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- morpholinobenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 337::US9663496, Compound 337	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328199&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710674	384583114							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817017	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H32F3N5O4/c33-32(34,35)44-28-8-3-23(4-9-28)21-39-15-11-25(12-16-39)38-30(41)24-5-10-29(37-20-24)31(42)40-17-13-27(14-18-40)43-26-6-1-22(19-36)2-7-26/h1-10,20,25,27H,11-18,21H2,(H,38,41)	DSZCBNUFKPZERX-UHFFFAOYSA-N	328200	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 338::US9663496, Compound 338	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328200&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710640	384583115							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817018	FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H31F3N6O2/c32-31(33,34)25-6-8-27(9-7-25)39-15-17-40(18-16-39)30(42)24-5-10-28(36-20-24)29(41)37-26-11-13-38(14-12-26)21-23-3-1-22(19-35)2-4-23/h1-10,20,26H,11-18,21H2,(H,37,41)	ZRFMAUMUQYAFKO-UHFFFAOYSA-N	328201	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethyl)phenyl)  piperazine-1- carbonyl)picolinamide::US10377742, Compound 339::US9663496, Compound 339	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328201&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			53476411	384583116							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817019	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1ccc(cc1)C#N	InChI=1S/C31H31N7O2/c32-19-23-1-3-25(4-2-23)22-36-13-11-27(12-14-36)35-30(39)29-10-7-26(21-34-29)31(40)38-17-15-37(16-18-38)28-8-5-24(20-33)6-9-28/h1-10,21,27H,11-18,22H2,(H,35,39)	SVZYBPGZXSSLEB-UHFFFAOYSA-N	328202	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cyanophenyl)piperazne- 1-carbonyl)picolinamide::US10377742, Compound 340::US9663496, Compound 340	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328202&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			53476410	384583117							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817020	Fc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C30H31FN6O2/c31-25-6-8-27(9-7-25)36-15-17-37(18-16-36)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-35(14-12-26)21-23-3-1-22(19-32)2-4-23/h1-10,20,26H,11-18,21H2,(H,34,38)	KAPJCNOKYHCMQW-UHFFFAOYSA-N	328203	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- fluorophenyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 341::US9663496, Compound 341	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328203&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710406	384583118							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817021	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-20-2-6-23(7-3-20)41-27-10-5-22(17-35-27)36-29(39)26-9-1-19(16-34-26)30(40)37-13-11-18(12-14-37)28(38)24-8-4-21(32)15-25(24)33/h1-10,15-18H,11-14H2,(H,36,39)	QGQJHZASQZDJMZ-UHFFFAOYSA-N	328204	5-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 342::US9663496, Compound 342	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328204&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710716	384583119							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817022	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(F)cc3F)cn2)cc1	InChI=1S/C29H23F3N4O4/c30-19-2-6-22(7-3-19)40-27-10-5-21(17-34-27)35-28(37)18-1-8-25(33-16-18)29(38)36-13-11-23(12-14-36)39-26-9-4-20(31)15-24(26)32/h1-10,15-17,23H,11-14H2,(H,35,37)	GUJSBGWSDRFUAC-UHFFFAOYSA-N	328205	6-(4-(2,4- difluorophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 343::US9663496, Compound 343	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328205&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710555	384583120							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817023	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(F)cc2F)cc1	InChI=1S/C31H34F2N4O4/c1-40-25-6-2-21(3-7-25)20-36-14-10-24(11-15-36)35-30(38)22-4-8-28(34-19-22)31(39)37-16-12-26(13-17-37)41-29-9-5-23(32)18-27(29)33/h2-9,18-19,24,26H,10-17,20H2,1H3,(H,35,38)	XRBKWKWORRIBMT-UHFFFAOYSA-N	328206	6-(4-(2,4- difluorophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 344::US9663496, Compound 344	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328206&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710858	384583121							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817024	Fc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C31H31F2N5O3/c32-24-6-8-29(27(33)17-24)41-26-11-15-38(16-12-26)31(40)28-7-5-23(19-35-28)30(39)36-25-9-13-37(14-10-25)20-22-3-1-21(18-34)2-4-22/h1-8,17,19,25-26H,9-16,20H2,(H,36,39)	CQZOSLVFDRPCFJ-UHFFFAOYSA-N	328207	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2,4- difluorophenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 345::US9663496, Compound 345	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328207&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710857	384583122							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817025	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1	InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)29-8-5-24(19-36-29)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	CZGHJHFJDOKLEU-UHFFFAOYSA-N	328208	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 346::US9663496, Compound 346	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328208&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710841	384583123							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817026	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(F)cc2F)cc1	InChI=1S/C32H34F2N4O4/c1-42-26-6-2-21(3-7-26)20-37-14-12-25(13-15-37)36-31(40)23-4-9-29(35-19-23)32(41)38-16-10-22(11-17-38)30(39)27-8-5-24(33)18-28(27)34/h2-9,18-19,22,25H,10-17,20H2,1H3,(H,36,40)	SNUABOBOUCELJX-UHFFFAOYSA-N	328209	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 347::US9663496, Compound 347	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328209&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710714	384583124							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817027	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C30H23F3N4O4/c31-20-2-6-23(7-3-20)41-27-10-5-22(17-35-27)36-29(39)19-1-9-26(34-16-19)30(40)37-13-11-18(12-14-37)28(38)24-8-4-21(32)15-25(24)33/h1-10,15-18H,11-14H2,(H,36,39)	MMDHXUCOBFMXDW-UHFFFAOYSA-N	328210	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 348::US9663496, Compound 348	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328210&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710581	384583125							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817028	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m1/s1	LEUSDRGCPVXECX-FQLXRVMXSA-N	328314	N-((3R,4R)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 452::US9663496, Compound 452	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328314&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652376	384573241							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817029	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@H]1F	InChI=1S/C33H34F4N4O5/c1-45-25-9-4-22(5-10-25)30(42)23-12-16-41(17-13-23)32(44)29-11-6-24(18-38-29)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-26(8-3-21)46-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28-/m1/s1	HWOSDYNCBXZMQP-VSGBNLITSA-N	409324	N-((trans)-3-fluoro-1-(4- (trifluoromethoxy)benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 350	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409324&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710760	406790900							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817030	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C30H31N7O2/c31-19-22-1-3-24(4-2-22)21-36-15-11-25(12-16-36)33-30(38)28-9-10-29(35-34-28)37-17-13-27(14-18-37)39-26-7-5-23(20-32)6-8-26/h1-10,25,27H,11-18,21H2,(H,33,38)	NSZYFVPQFQAZIY-UHFFFAOYSA-N	328213	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- cyanophenoxy)piperidin- 1-yl)pyridazine-3- carboxamide::US10377742, Compound 351::US9663496, Compound 351	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328213&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710647	384583128							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817031	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)N2CCCC2)C[C@H]1F	InChI=1S/C36H42FN5O4/c1-46-30-11-6-26(7-12-30)34(43)27-14-20-42(21-15-27)36(45)33-13-8-28(22-38-33)35(44)39-32-16-19-40(24-31(32)37)23-25-4-9-29(10-5-25)41-17-2-3-18-41/h4-13,22,27,31-32H,2-3,14-21,23-24H2,1H3,(H,39,44)/t31-,32-/m1/s1	GMBOADRJUJIWFX-ROJLCIKYSA-N	409326	N-((trans)-3-fluoro-1-(4-(pyrrolidin-1- yl)benzyl)piperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 352	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409326&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710350	406790902							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817032	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(C)C)cc2)C[C@H]1F	InChI=1S/C35H41FN4O5/c1-23(2)45-29-9-4-24(5-10-29)21-39-17-16-31(30(36)22-39)38-34(42)27-8-13-32(37-20-27)35(43)40-18-14-26(15-19-40)33(41)25-6-11-28(44-3)12-7-25/h4-13,20,23,26,30-31H,14-19,21-22H2,1-3H3,(H,38,42)/t30-,31-/m1/s1	MPRAAOIVYGMJKJ-FIRIVFDPSA-N	409327	N-((trans)-3-fluoro-1-(4- isopropoxybenzyl)piperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 353	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409327&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710630	406790903							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817033	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(C#N)c(F)c2)C[C@H]1F	InChI=1S/C33H33F2N5O4/c1-44-26-7-4-22(5-8-26)31(41)23-10-14-40(15-11-23)33(43)30-9-6-25(18-37-30)32(42)38-29-12-13-39(20-28(29)35)19-21-2-3-24(17-36)27(34)16-21/h2-9,16,18,23,28-29H,10-15,19-20H2,1H3,(H,38,42)/t28-,29-/m1/s1	XSTWHJANPVSKRP-FQLXRVMXSA-N	409328	N-((trans)-1-(4-cyano-3-fluorobenzyl)-3- fluoropiperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 354	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409328&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710730	406790904							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817034	O=C(NC1CCN(Cc2cocn2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C28H30N6O4/c29-15-20-1-4-24(5-2-20)38-25-9-13-34(14-10-25)28(36)26-6-3-21(16-30-26)27(35)32-22-7-11-33(12-8-22)17-23-18-37-19-31-23/h1-6,16,18-19,22,25H,7-14,17H2,(H,32,35)	MZHVANYWYUEJSQ-UHFFFAOYSA-N	328217	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(oxazol-4- ylmethyl)piperidin-4- yl)nicotinamide::US10377742, Compound 355::US9663496, Compound 355	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328217&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710394	384583132							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817035	O=C(NC1CCN(Cc2nccs2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C28H30N6O3S/c29-17-20-1-4-23(5-2-20)37-24-9-14-34(15-10-24)28(36)25-6-3-21(18-31-25)27(35)32-22-7-12-33(13-8-22)19-26-30-11-16-38-26/h1-6,11,16,18,22,24H,7-10,12-15,19H2,(H,32,35)	SMBYEQDVWMFBTL-UHFFFAOYSA-N	328218	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(thiazol-2- ylmethyl)piperidin-4- yl)nicotinamide::US10377742, Compound 356::US9663496, Compound 356	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328218&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710626	384583133							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817036	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C34H38N6O4/c1-38(2)33(42)26-7-10-29(11-8-26)44-30-15-19-40(20-16-30)34(43)27-9-12-31(36-22-27)32(41)37-28-13-17-39(18-14-28)23-25-5-3-24(21-35)4-6-25/h3-12,22,28,30H,13-20,23H2,1-2H3,(H,37,41)	HUYCPHYFJJCRHE-UHFFFAOYSA-N	328219	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 357::US9663496, Compound 357	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328219&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710491	384583134							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817037	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H35N5O4/c1-23(39)26-6-9-29(10-7-26)42-30-14-18-38(19-15-30)33(41)27-8-11-31(35-21-27)32(40)36-28-12-16-37(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)	CGANLALLTGBPTO-UHFFFAOYSA-N	328220	5-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 358::US9663496, Compound 358	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328220&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710604	384583135							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817038	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)22-4-12-28(33-18-22)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	UGQQVZAGWFGYST-UHFFFAOYSA-N	328221	5-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 359::US9663496, Compound 359	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328221&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710752	384583136							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817039	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C32H30FN5O5/c1-37(2)31(40)21-3-9-25(10-4-21)42-27-15-17-38(18-16-27)32(41)22-5-13-28(34-19-22)30(39)36-24-8-14-29(35-20-24)43-26-11-6-23(33)7-12-26/h3-14,19-20,27H,15-18H2,1-2H3,(H,36,39)	BBMMNIYHXIHSPL-UHFFFAOYSA-N	328222	5-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 360::US9663496, Compound 360	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328222&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710272	384583137							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817040	FC(F)(F)c1ccc(OC2CCN(CC2)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C30H31F3N6O2/c31-30(32,33)23-5-7-25(8-6-23)41-26-13-17-39(18-14-26)28-10-9-27(36-37-28)29(40)35-24-11-15-38(16-12-24)20-22-3-1-21(19-34)2-4-22/h1-10,24,26H,11-18,20H2,(H,35,40)	YTSTYPROPVLXLB-UHFFFAOYSA-N	328223	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethyl)  phenoxy)piperidin-1- yl)pyridazine-3- carboxamide::US10377742, Compound 361::US9663496, Compound 361	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328223&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710281	384583138							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817041	COc1ccc(cc1)C(=O)C1CCN(CC1)c1ccc(nn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H34N6O3/c1-40-27-8-6-24(7-9-27)30(38)25-12-18-37(19-13-25)29-11-10-28(34-35-29)31(39)33-26-14-16-36(17-15-26)21-23-4-2-22(20-32)3-5-23/h2-11,25-26H,12-19,21H2,1H3,(H,33,39)	UZPPXFTWQGIEIS-UHFFFAOYSA-N	409336	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-methoxybenzoyl)piperidin-1- yl)pyridazine-3-carboxamide::US10377742, Compound 362	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409336&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710610	406790912							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817042	[O-][N+](=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32N6O5/c32-19-22-1-3-23(4-2-22)21-35-15-11-25(12-16-35)34-30(38)24-5-10-29(33-20-24)31(39)36-17-13-28(14-18-36)42-27-8-6-26(7-9-27)37(40)41/h1-10,20,25,28H,11-18,21H2,(H,34,38)	DSEUJSHMFHEHFZ-UHFFFAOYSA-N	328225	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- nitrophenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 363::US9663496, Compound 363	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328225&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710493	384583140							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817043	Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O3/c32-19-22-1-3-23(4-2-22)21-36-15-11-26(12-16-36)35-30(38)24-5-10-29(34-20-24)31(39)37-17-13-28(14-18-37)40-27-8-6-25(33)7-9-27/h1-10,20,26,28H,11-18,21,33H2,(H,35,38)	IJVKVAYSNCCZQF-UHFFFAOYSA-N	328226	6-(4-(4-aminophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 364::US9663496, Compound 364	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328226&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710347	384583141							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817044	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C36H40N6O3/c37-23-26-3-5-27(6-4-26)25-40-19-15-31(16-20-40)39-35(44)33-12-9-30(24-38-33)36(45)42-21-13-29(14-22-42)34(43)28-7-10-32(11-8-28)41-17-1-2-18-41/h3-12,24,29,31H,1-2,13-22,25H2,(H,39,44)	UXNBFMGMBOACEC-UHFFFAOYSA-N	409339	N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4- (4-(pyrrolidin-1-yl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 365	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409339&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710534	406790915							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817045	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H36N6O4/c1-23(40)36-27-7-9-29(10-8-27)43-30-14-18-39(19-15-30)33(42)31-11-6-26(21-35-31)32(41)37-28-12-16-38(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)(H,37,41)	GNMBIYXIFWVHBU-UHFFFAOYSA-N	328228	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 366::US9663496, Compound 366	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328228&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710449	384583143							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817046	CS(=O)(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H36N6O5S/c1-44(41,42)36-27-7-9-28(10-8-27)43-29-14-18-38(19-15-29)32(40)30-11-6-25(21-34-30)31(39)35-26-12-16-37(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29,36H,12-19,22H2,1H3,(H,35,39)	GJMRQEGEEYASHD-UHFFFAOYSA-N	328229	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (methylsulfonamido)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 367::US9663496, Compound 367	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328229&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710731	384583144							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817047	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCCC3)cn2)cc1	InChI=1S/C34H32FN5O4/c35-26-6-11-29(12-7-26)44-31-14-8-27(22-37-31)38-33(42)30-13-5-25(21-36-30)34(43)40-19-15-24(16-20-40)32(41)23-3-9-28(10-4-23)39-17-1-2-18-39/h3-14,21-22,24H,1-2,15-20H2,(H,38,42)	STPZXMKMNKFXAI-UHFFFAOYSA-N	328230	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)picolinamide::US10377742, Compound 368::US9663496, Compound 368	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328230&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710458	384583145							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817048	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)C#N	InChI=1S/C33H32N6O3/c34-19-23-1-3-25(4-2-23)22-38-15-13-29(14-16-38)37-32(41)30-10-9-28(21-36-30)33(42)39-17-11-27(12-18-39)31(40)26-7-5-24(20-35)6-8-26/h1-10,21,27,29H,11-18,22H2,(H,37,41)	NGDYCJGYGAYDIM-UHFFFAOYSA-N	328231	5-(4-(4-cyanobenzoyl)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 369::US9663496, Compound 369	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328231&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710591	384583146							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817049	CN(C)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C34H38N6O3/c1-38(2)30-10-7-26(8-11-30)32(41)27-13-19-40(20-14-27)34(43)31-12-9-28(22-36-31)33(42)37-29-15-17-39(18-16-29)23-25-5-3-24(21-35)4-6-25/h3-12,22,27,29H,13-20,23H2,1-2H3,(H,37,42)	AJYLLLGCOILHRH-UHFFFAOYSA-N	409344	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-(dimethylamino)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 370	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409344&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			134300170	406790920							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817050	O=C(CCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C51H67N9O10S/c52-32-36-4-6-37(7-5-36)34-59-20-14-40(15-21-59)56-49(63)38-8-13-43(54-33-38)50(64)60-22-16-42(17-23-60)70-41-11-9-39(10-12-41)55-47(62)18-24-66-26-28-68-30-31-69-29-27-67-25-19-53-46(61)3-1-2-45-48-44(35-71-45)57-51(65)58-48/h4-13,33,40,42,44-45,48H,1-3,14-31,34-35H2,(H,53,61)(H,55,62)(H,56,63)(H2,57,58,65)/t44-,45-,48-/m0/s1	FDMHQQSOTGDXCF-UMQMWPJCSA-N	328233	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(17-oxo-20- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10,13-tetraoxa- 16- azaicosanamido)phenoxy )piperidine-1- carbonyl)nicotinamide::US10377742, Compound 371::US9663496, Compound 371	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328233&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119947	384583148							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817051	CSc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H35N5O3S/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	FCLDRVKLOOYCDQ-UHFFFAOYSA-N	328234	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (methylthio)benzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 372::US9663496, Compound 372	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328234&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710721	384583149							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817052	CSc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)[N+]([O-])=O)CC1	InChI=1S/C32H35N5O5S/c1-43-28-9-4-23(5-10-28)30(38)24-12-18-36(19-13-24)32(40)29-11-6-25(20-33-29)31(39)34-26-14-16-35(17-15-26)21-22-2-7-27(8-3-22)37(41)42/h2-11,20,24,26H,12-19,21H2,1H3,(H,34,39)	ZDKXCRDPYIEKMR-UHFFFAOYSA-N	328235	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4- nitrobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 373::US9663496, Compound 373	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328235&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			122486211	384583150							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817053	CS(=O)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CC[N](O)(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H36N5O5S/c1-44(43)29-9-6-25(7-10-29)31(39)26-12-16-37(17-13-26)33(41)27-8-11-30(35-21-27)32(40)36-28-14-18-38(42,19-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28,42H,12-19,22H2,1H3,(H,36,40)	JVGCPHCLKAXZJD-UHFFFAOYSA-N	409348	1-(4-cyanobenzyl)-4-(5-(4-(4- (methylsulfinyl)benzoyl)piperidine-1- carbonyl)picolinamido)piperidine 1-oxide::US10377742, Compound 374	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409348&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			123509830	406790924							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817054	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)-n1cccn1	InChI=1S/C35H35N7O3/c36-22-25-2-4-26(5-3-25)24-40-18-14-30(15-19-40)39-34(44)32-11-8-29(23-37-32)35(45)41-20-12-28(13-21-41)33(43)27-6-9-31(10-7-27)42-17-1-16-38-42/h1-11,16-17,23,28,30H,12-15,18-21,24H2,(H,39,44)	CYNGANONKKUHAT-UHFFFAOYSA-N	328237	5-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)picolinamide::US10377742, Compound 375::US9663496, Compound 375	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328237&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710742	384583152							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817055	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCOCC1	InChI=1S/C36H40N6O4/c37-23-26-1-3-27(4-2-26)25-40-15-13-31(14-16-40)39-35(44)33-10-7-30(24-38-33)36(45)42-17-11-29(12-18-42)34(43)28-5-8-32(9-6-28)41-19-21-46-22-20-41/h1-10,24,29,31H,11-22,25H2,(H,39,44)	WCBBIBOXLBNHOV-UHFFFAOYSA-N	328238	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- morpholinobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 376::US9663496, Compound 376	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328238&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710482	384583153							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817056	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C36H40N6O3/c37-23-26-3-5-27(6-4-26)25-40-19-15-31(16-20-40)39-35(44)30-9-12-33(38-24-30)36(45)42-21-13-29(14-22-42)34(43)28-7-10-32(11-8-28)41-17-1-2-18-41/h3-12,24,29,31H,1-2,13-22,25H2,(H,39,44)	JHDUODWCMKEUJW-UHFFFAOYSA-N	328239	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 377::US9663496, Compound 377	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328239&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710745	384583154							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817057	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(c1)[N+]([O-])=O	InChI=1S/C32H34N6O6/c1-43-27-7-9-30(29(18-27)38(41)42)44-26-12-16-37(17-13-26)32(40)28-8-6-24(20-34-28)31(39)35-25-10-14-36(15-11-25)21-23-4-2-22(19-33)3-5-23/h2-9,18,20,25-26H,10-17,21H2,1H3,(H,35,39)	PNQUXRANYGABJB-UHFFFAOYSA-N	328240	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-methoxy-2- nitrophenoxy)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 378::US9663496, Compound 378	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328240&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710644	384583155							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817058	Fc1ccc(Oc2ccc(NC(=O)c3ccc(cn3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCOCC3)cn2)cc1	InChI=1S/C34H32FN5O5/c35-26-4-9-29(10-5-26)45-31-12-6-27(22-37-31)38-33(42)30-11-3-25(21-36-30)34(43)40-15-13-24(14-16-40)32(41)23-1-7-28(8-2-23)39-17-19-44-20-18-39/h1-12,21-22,24H,13-20H2,(H,38,42)	GMARCTCAIUDFNX-UHFFFAOYSA-N	328241	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-5-(4-(4- morpholinobenzoyl)  piperidine-1- carbonyl)picolinamide::US10377742, Compound 379::US9663496, Compound 379	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328241&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710846	384583156							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817059	CN1CCN(CC1)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C37H43N7O3/c1-41-20-22-43(23-21-41)33-9-6-29(7-10-33)35(45)30-12-18-44(19-13-30)37(47)31-8-11-34(39-25-31)36(46)40-32-14-16-42(17-15-32)26-28-4-2-27(24-38)3-5-28/h2-11,25,30,32H,12-23,26H2,1H3,(H,40,46)	CQUHOAICBBXVEG-UHFFFAOYSA-N	328242	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-(4- methylpiperazin-1- yl)benzoyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 380::US9663496, Compound 380	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328242&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710545	384583157							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817060	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C35H40FN5O3/c36-29-8-3-25(4-9-29)24-39-19-15-30(16-20-39)38-34(43)28-7-12-32(37-23-28)35(44)41-21-13-27(14-22-41)33(42)26-5-10-31(11-6-26)40-17-1-2-18-40/h3-12,23,27,30H,1-2,13-22,24H2,(H,38,43)	INGGFDWTZNSBPY-UHFFFAOYSA-N	328243	N-(1-(4- fluorobenzyl)piperidin- 4-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 381::US9663496, Compound 381	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328243&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710596	384583158							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817061	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(cc3)N3CCCC3)cn2)cc1	InChI=1S/C34H32FN5O4/c35-26-6-11-29(12-7-26)44-31-14-8-27(22-37-31)38-33(42)25-5-13-30(36-21-25)34(43)40-19-15-24(16-20-40)32(41)23-3-9-28(10-4-23)39-17-1-2-18-39/h3-14,21-22,24H,1-2,15-20H2,(H,38,42)	AECCUDKFJGLGKU-UHFFFAOYSA-N	328244	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 382::US9663496, Compound 382	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328244&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710400	384583159							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817062	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NC(C)=O)c1	InChI=1S/C34H38N6O5/c1-23(41)37-31-19-29(44-2)8-10-32(31)45-28-13-17-40(18-14-28)34(43)30-9-7-26(21-36-30)33(42)38-27-11-15-39(16-12-27)22-25-5-3-24(20-35)4-6-25/h3-10,19,21,27-28H,11-18,22H2,1-2H3,(H,37,41)(H,38,42)	YZTYOHDMZFCQJX-UHFFFAOYSA-N	328245	6-(4-(2-acetamido-4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 383::US9663496, Compound 383	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328245&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710679	384573172							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817063	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(N)c1	InChI=1S/C32H36N6O4/c1-41-27-7-9-30(28(34)18-27)42-26-12-16-38(17-13-26)32(40)29-8-6-24(20-35-29)31(39)36-25-10-14-37(15-11-25)21-23-4-2-22(19-33)3-5-23/h2-9,18,20,25-26H,10-17,21,34H2,1H3,(H,36,39)	PADKHLIKCSPVGB-UHFFFAOYSA-N	328246	6-(4-(2-amino-4- methoxyphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 384::US9663496, Compound 384	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328246&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710732	384573173							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817064	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(c1)N(C)C	InChI=1S/C34H40N6O4/c1-38(2)31-20-29(43-3)9-11-32(31)44-28-14-18-40(19-15-28)34(42)30-10-8-26(22-36-30)33(41)37-27-12-16-39(17-13-27)23-25-6-4-24(21-35)5-7-25/h4-11,20,22,27-28H,12-19,23H2,1-3H3,(H,37,41)	USKHWBFFPMZFMQ-UHFFFAOYSA-N	328247	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(2- (dimethylamino)-4- methoxyphenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 385::US9663496, Compound 385	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328247&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710571	384573174							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817065	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N8O2/c33-19-23-1-5-25(6-2-23)21-39-15-11-27(12-16-39)35-31(41)29-9-10-30(38-37-29)32(42)36-28-13-17-40(18-14-28)22-26-7-3-24(20-34)4-8-26/h1-10,27-28H,11-18,21-22H2,(H,35,41)(H,36,42)	DOZGCVLBIVAPAB-UHFFFAOYSA-N	328248	N3,N6-bis(1-(4- cyanobenzyl)piperidin-4- yl)pyridazine-3,6- dicarboxamide::US10377742, Compound 386::US9663496, Compound 386	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328248&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710695	384573175							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817066	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C32H34N6O4/c1-42-27-8-6-24(7-9-27)30(39)25-12-18-38(19-13-25)32(41)29-11-10-28(35-36-29)31(40)34-26-14-16-37(17-15-26)21-23-4-2-22(20-33)3-5-23/h2-11,25-26H,12-19,21H2,1H3,(H,34,40)	ZLENIQODLNSTCZ-UHFFFAOYSA-N	328249	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyridazine-3- carboxamide::US10377742, Compound 387::US9663496, Compound 387	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328249&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710466	384573176							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817067	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H31N7O3/c32-19-22-1-3-24(4-2-22)21-37-15-11-25(12-16-37)34-30(39)28-9-10-29(36-35-28)31(40)38-17-13-27(14-18-38)41-26-7-5-23(20-33)6-8-26/h1-10,25,27H,11-18,21H2,(H,34,39)	BZJYUHBEBJBKFU-UHFFFAOYSA-N	409362	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-cyanophenoxy)piperidine-1- carbonyl)pyridazine-3-carboxamide::US10377742, Compound 388	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409362&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710613	406790938							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817068	CNc1cc(OC)ccc1OC1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C33H38N6O4/c1-35-30-19-28(42-2)8-10-31(30)43-27-13-17-39(18-14-27)33(41)29-9-7-25(21-36-29)32(40)37-26-11-15-38(16-12-26)22-24-5-3-23(20-34)4-6-24/h3-10,19,21,26-27,35H,11-18,22H2,1-2H3,(H,37,40)	OLOZIBNMGBLLJM-UHFFFAOYSA-N	409363	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-methoxy-2- (methylsulfonamido)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 389	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409363	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409363&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676212	406790939							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817069	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C33H35N5O4/c1-23(39)26-6-9-29(10-7-26)42-30-14-18-38(19-15-30)33(41)31-11-8-27(21-35-31)32(40)36-28-12-16-37(17-13-28)22-25-4-2-24(20-34)3-5-25/h2-11,21,28,30H,12-19,22H2,1H3,(H,36,40)	VPANDGDZYUHJNA-UHFFFAOYSA-N	328252	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 390::US9663496, Compound 390	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328252&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710332	384573179							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817070	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H35FN4O4/c1-22(38)24-4-9-28(10-5-24)41-29-14-18-37(19-15-29)32(40)30-11-6-25(20-34-30)31(39)35-27-12-16-36(17-13-27)21-23-2-7-26(33)8-3-23/h2-11,20,27,29H,12-19,21H2,1H3,(H,35,39)	KSGRCIGWEWONAI-UHFFFAOYSA-N	328253	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 391::US9663496, Compound 391	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328253&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710670	384573180							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817071	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)-n2cccn2)cc1	InChI=1S/C34H35FN6O3/c35-28-7-2-24(3-8-28)23-39-18-14-29(15-19-39)38-33(43)27-6-11-31(36-22-27)34(44)40-20-12-26(13-21-40)32(42)25-4-9-30(10-5-25)41-17-1-16-37-41/h1-11,16-17,22,26,29H,12-15,18-21,23H2,(H,38,43)	BUMYTKZYNNGHLL-UHFFFAOYSA-N	328254	6-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 392::US9663496, Compound 392	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328254&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710817	384573181							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817072	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)-n1cccn1	InChI=1S/C35H35N7O3/c36-22-25-2-4-26(5-3-25)24-40-18-14-30(15-19-40)39-34(44)29-8-11-32(37-23-29)35(45)41-20-12-28(13-21-41)33(43)27-6-9-31(10-7-27)42-17-1-16-38-42/h1-11,16-17,23,28,30H,12-15,18-21,24H2,(H,39,44)	RUVMWHOZYSQUPX-UHFFFAOYSA-N	328255	6-(4-(4-(1H-pyrazol-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 393::US9663496, Compound 393	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328255&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710667	384573182							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817073	COc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c1	InChI=1S/C53H71N9O11S/c1-68-42-11-13-46(73-41-16-22-62(23-17-41)52(66)43-12-10-39(34-56-43)51(65)57-40-14-20-61(21-15-40)35-38-8-6-37(33-54)7-9-38)44(32-42)58-49(64)18-24-69-26-28-71-30-31-72-29-27-70-25-19-55-48(63)5-3-2-4-47-50-45(36-74-47)59-53(67)60-50/h6-13,32,34,40-41,45,47,50H,2-5,14-31,35-36H2,1H3,(H,55,63)(H,57,65)(H,58,64)(H2,59,60,67)/t45-,47-,50-/m0/s1	VCUZCXZAVWJMRB-VZRKZVDPSA-N	328256	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4-methoxy-2- (17-oxo-21- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10,13-tetraoxa- 16-azahenicosanamido)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 394::US9663496, Compound 394	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328256&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119971	384573183							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817074	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H27FN4O5/c1-20(37)21-2-8-25(9-3-21)40-27-14-16-36(17-15-27)31(39)28-12-4-22(18-33-28)30(38)35-24-7-13-29(34-19-24)41-26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	PCKCBYIEMJBCQJ-UHFFFAOYSA-N	328257	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 395::US9663496, Compound 395	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328257&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710299	384573184							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817075	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C31H35FN4O3/c1-22-2-9-27(10-3-22)39-28-14-18-36(19-15-28)31(38)29-11-6-24(20-33-29)30(37)34-26-12-16-35(17-13-26)21-23-4-7-25(32)8-5-23/h2-11,20,26,28H,12-19,21H2,1H3,(H,34,37)	UUZOPWSYPZJFBK-UHFFFAOYSA-N	409370	N-(1-(4-fluorobenzyl)piperidin-4-yl)-6-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 396	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409370	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409370&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676213	406790946							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817076	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H35N5O3/c1-23-2-9-28(10-3-23)40-29-14-18-37(19-15-29)32(39)30-11-8-26(21-34-30)31(38)35-27-12-16-36(17-13-27)22-25-6-4-24(20-33)5-7-25/h2-11,21,27,29H,12-19,22H2,1H3,(H,35,38)	PQDNQTAVIFKNLY-UHFFFAOYSA-N	409371	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 397	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409371	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409371&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676214	406790947							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817077	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C32H34N4O4/c1-22-2-9-26(10-3-22)40-29-16-18-36(19-17-29)32(38)30-15-6-24(21-34-30)31(37)35-25-7-13-28(14-8-25)39-27-11-4-23(20-33)5-12-27/h2-6,9-12,15,21,25,28-29H,7-8,13-14,16-19H2,1H3,(H,35,37)	WKVDROGTYQLCHC-UHFFFAOYSA-N	409372	N-(4-(4-cyanophenoxy)cyclohexyl)-6-(4-(4- (methylsulfonyl)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 398	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409372	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409372&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676215	406790948							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817078	Cc1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H34N6O3/c1-22-2-8-26(9-3-22)40-27-14-18-37(19-15-27)31(39)29-11-10-28(34-35-29)30(38)33-25-12-16-36(17-13-25)21-24-6-4-23(20-32)5-7-24/h2-11,25,27H,12-19,21H2,1H3,(H,33,38)	RFYYTEWAEFWDKF-UHFFFAOYSA-N	409373	N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)pyridazine-3-carboxamide::US10377742, Compound 399	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409373	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409373&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676216	406790949							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817079	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(N)cc2)CC1	InChI=1S/C32H37N5O4/c1-41-28-9-4-23(5-10-28)30(38)24-12-18-37(19-13-24)32(40)29-11-6-25(20-34-29)31(39)35-27-14-16-36(17-15-27)21-22-2-7-26(33)8-3-22/h2-11,20,24,27H,12-19,21,33H2,1H3,(H,35,39)	RIUDPAORZJBEQE-UHFFFAOYSA-N	328262	N-(1-(4- aminobenzyl)piperidin- 4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 400::US9663496, Compound 400	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328262&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710436	384573189							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817080	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(NC(C)=O)cc2)CC1	InChI=1S/C34H39N5O5/c1-23(40)36-28-8-3-24(4-9-28)22-38-17-15-29(16-18-38)37-33(42)27-7-12-31(35-21-27)34(43)39-19-13-26(14-20-39)32(41)25-5-10-30(44-2)11-6-25/h3-12,21,26,29H,13-20,22H2,1-2H3,(H,36,40)(H,37,42)	HVGXPVKSQJFBCU-UHFFFAOYSA-N	328263	N-(1-(4- acetamidobenzyl)  piperidin-4-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 401::US9663496, Compound 401	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328263&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710516	384573190							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817081	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCC(CC2)Oc2ccc(cc2)C#N)cc1	InChI=1S/C33H34N4O5/c1-22(38)24-4-11-28(12-5-24)42-30-16-18-37(19-17-30)33(40)31-15-6-25(21-35-31)32(39)36-26-7-13-29(14-8-26)41-27-9-2-23(20-34)3-10-27/h2-6,9-12,15,21,26,29-30H,7-8,13-14,16-19H2,1H3,(H,36,39)	RKZZIRZVMZFRAJ-UHFFFAOYSA-N	409376	6-(4-(4-acetylphenoxy)piperidine-1- carbonyl)-N-(4-(4- cyanophenoxy)cyclohexyl)nicotinamide::US10377742, Compound 402	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409376	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409376&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710377	406790952							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817082	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(NC(=O)CCOCCOCCOCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)cc2)CC1	InChI=1S/C51H68N8O10S/c1-66-41-13-8-36(9-14-41)48(62)37-16-24-59(25-17-37)50(64)38-10-15-42(53-32-38)49(63)55-40-18-22-58(23-19-40)33-35-6-11-39(12-7-35)54-46(61)20-26-67-28-30-69-31-29-68-27-21-52-45(60)5-3-2-4-44-47-43(34-70-44)56-51(65)57-47/h6-15,32,37,40,43-44,47H,2-5,16-31,33-34H2,1H3,(H,52,60)(H,54,61)(H,55,63)(H2,56,57,65)/t43-,44-,47-/m0/s1	HVUHUGNDUZGZJI-NVVQJRFUSA-N	328265	5-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-(14-oxo-18- ((3aS,4S,6aR)-2- oxohexahydro-1H- thieno[3,4-d]imidazol-4- yl)-4,7,10-trioxa-13- azaoctadecanamido)  benzyl)piperidin-4- yl)picolinamide::US10377742, Compound 403::US9663496, Compound 403	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328265&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119942	384573192							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817083	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(CC2)c2ccc(F)cc2)cc1	InChI=1S/C29H31F2N5O2/c30-23-4-1-21(2-5-23)20-34-15-17-36(18-16-34)29(38)27-10-3-22(19-32-27)28(37)33-25-11-13-35(14-12-25)26-8-6-24(31)7-9-26/h1-10,19,25H,11-18,20H2,(H,33,37)	VGOONDYBJSKCBN-UHFFFAOYSA-N	328266	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- fluorophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 404::US9663496, Compound 404	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328266&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710412	384573193							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817084	COc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H34FN5O3/c1-39-27-9-7-26(8-10-27)35-14-12-25(13-15-35)33-29(37)23-4-11-28(32-20-23)30(38)36-18-16-34(17-19-36)21-22-2-5-24(31)6-3-22/h2-11,20,25H,12-19,21H2,1H3,(H,33,37)	FKSSSDMQVIYXCQ-UHFFFAOYSA-N	328267	6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1-(4- methoxyphenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 405::US9663496, Compound 405	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328267&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710479	384573194							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817085	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)cc1	InChI=1S/C32H36FN5O4/c1-22(39)35-26-7-9-28(10-8-26)42-29-14-18-38(19-15-29)32(41)30-11-4-24(20-34-30)31(40)36-27-12-16-37(17-13-27)21-23-2-5-25(33)6-3-23/h2-11,20,27,29H,12-19,21H2,1H3,(H,35,39)(H,36,40)	YQMZZWAQXKEZOB-UHFFFAOYSA-N	328268	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 406::US9663496, Compound 406	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328268&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710323	384573195							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817086	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(NC(C)=O)cc2)cc1	InChI=1S/C33H39N5O5/c1-23(39)35-26-6-10-29(11-7-26)43-30-15-19-38(20-16-30)33(41)31-12-5-25(21-34-31)32(40)36-27-13-17-37(18-14-27)22-24-3-8-28(42-2)9-4-24/h3-12,21,27,30H,13-20,22H2,1-2H3,(H,35,39)(H,36,40)	XYVPQYHJOMNWFW-UHFFFAOYSA-N	328269	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 407::US9663496, Compound 407	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328269	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328269&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710478	384573196							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817087	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)cc1	InChI=1S/C31H28FN5O5/c1-20(38)35-23-5-10-25(11-6-23)41-27-14-16-37(17-15-27)31(40)21-2-12-28(33-18-21)30(39)36-24-7-13-29(34-19-24)42-26-8-3-22(32)4-9-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)(H,36,39)	CZJQSTWTDOMTMC-UHFFFAOYSA-N	328270	5-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)picolinamide::US10377742, Compound 408::US9663496, Compound 408	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328270&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710378	384573197							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817088	O=C(Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1)C1CC1	InChI=1S/C35H38N6O4/c36-21-24-1-3-25(4-2-24)23-40-17-13-29(14-18-40)39-34(43)27-7-12-32(37-22-27)35(44)41-19-15-31(16-20-41)45-30-10-8-28(9-11-30)38-33(42)26-5-6-26/h1-4,7-12,22,26,29,31H,5-6,13-20,23H2,(H,38,42)(H,39,43)	MPYZAJHIMPJCAB-UHFFFAOYSA-N	328271	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropane- carboxamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 409::US9663496, Compound 409	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328271&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710456	384573198							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817089	FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O3S/c33-32(34,35)44-28-8-6-26(7-9-28)43-27-13-17-40(18-14-27)31(42)24-5-10-29(37-20-24)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	CUGRGOQWDRJFLR-UHFFFAOYSA-N	328272	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylthio)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 410::US9663496, Compound 410	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328272	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328272&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710755	384573199							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817090	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1	InChI=1S/C33H36N6O4/c1-23(40)36-28-3-2-4-30(19-28)43-29-13-17-39(18-14-29)33(42)31-10-9-26(21-35-31)32(41)37-27-11-15-38(16-12-27)22-25-7-5-24(20-34)6-8-25/h2-10,19,21,27,29H,11-18,22H2,1H3,(H,36,40)(H,37,41)	YBCMWZLNHLQBTF-UHFFFAOYSA-N	328273	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 411::US9663496, Compound 411	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328273	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328273&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710618	384573200							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817091	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(C)=O)c2)cc1	InChI=1S/C33H39N5O5/c1-23(39)35-27-4-3-5-30(20-27)43-29-14-18-38(19-15-29)33(41)31-11-8-25(21-34-31)32(40)36-26-12-16-37(17-13-26)22-24-6-9-28(42-2)10-7-24/h3-11,20-21,26,29H,12-19,22H2,1-2H3,(H,35,39)(H,36,40)	UFIJHORMJXQIKW-UHFFFAOYSA-N	328274	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 412::US9663496, Compound 412	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328274	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328274&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710399	384573201							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817092	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(F)cc3)CC2)c1	InChI=1S/C32H36FN5O4/c1-22(39)35-27-3-2-4-29(19-27)42-28-13-17-38(18-14-28)32(41)30-10-7-24(20-34-30)31(40)36-26-11-15-37(16-12-26)21-23-5-8-25(33)9-6-23/h2-10,19-20,26,28H,11-18,21H2,1H3,(H,35,39)(H,36,40)	QAQJNUIVHQIXNU-UHFFFAOYSA-N	328275	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 413::US9663496, Compound 413	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328275	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328275&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710376	384573202							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817093	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(F)cc3)nc2)c1	InChI=1S/C31H28FN5O5/c1-20(38)35-23-3-2-4-27(17-23)41-26-13-15-37(16-14-26)31(40)28-11-5-21(18-33-28)30(39)36-24-8-12-29(34-19-24)42-25-9-6-22(32)7-10-25/h2-12,17-19,26H,13-16H2,1H3,(H,35,38)(H,36,39)	HFTJORLORZXKEZ-UHFFFAOYSA-N	328276	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 414::US9663496, Compound 414	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328276	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328276&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710707	384573203							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817094	FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)24-5-10-29(37-20-24)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	LUSWURPIWQNHMX-UHFFFAOYSA-N	328277	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (trifluoromethylsulfonyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 415::US9663496, Compound 415	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328277	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328277&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710397	384573204							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817095	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ncc(cc1CCCNC(=O)OC(C)(C)C)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C41H50N6O6/c1-41(2,3)53-40(51)43-19-5-6-32-24-33(38(49)45-34-17-20-46(21-18-34)27-29-9-7-28(25-42)8-10-29)26-44-36(32)39(50)47-22-15-31(16-23-47)37(48)30-11-13-35(52-4)14-12-30/h7-14,24,26,31,34H,5-6,15-23,27H2,1-4H3,(H,43,51)(H,45,49)	UUICOLGNKPZDCW-UHFFFAOYSA-N	328278	US10377742, Compound 416::US9663496, Compound 416::tert-butyl 3-(5-(1-(4- cyanobenzyl)piperidin-4- ylcarbamoyl)-2-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)pyridin-3- yl)propylcarbamate	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328278	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328278&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710588	384573205							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817096	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(CC2)c2ccc(cc2)C#N)cc1	InChI=1S/C30H31FN6O2/c31-25-6-1-23(2-7-25)21-35-15-17-37(18-16-35)30(39)28-10-5-24(20-33-28)29(38)34-26-11-13-36(14-12-26)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)	MHLHQNWCMLCICH-UHFFFAOYSA-N	328279	N-(1-(4- cyanophenyl)piperidin- 4-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 417::US9663496, Compound 417	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328279	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328279&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710325	384573206							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817097	O=C(NC1CCN(CC1)c1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H30N6O3/c32-19-22-1-6-26(7-2-22)36-15-11-25(12-16-36)35-30(38)24-5-10-29(34-21-24)31(39)37-17-13-28(14-18-37)40-27-8-3-23(20-33)4-9-27/h1-10,21,25,28H,11-18H2,(H,35,38)	AMGOYODSYQCBIL-UHFFFAOYSA-N	328280	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 418::US9663496, Compound 418	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328280	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328280&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710612	384573207							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817098	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)C(=O)c1cccs1	InChI=1S/C30H31N5O3S/c31-18-21-3-5-22(6-4-21)20-34-13-11-25(12-14-34)33-29(37)26-8-7-24(19-32-26)30(38)35-15-9-23(10-16-35)28(36)27-2-1-17-39-27/h1-8,17,19,23,25H,9-16,20H2,(H,33,37)	HIVBNBYETREPDI-UHFFFAOYSA-N	328281	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(thiophene-2- carbonyl)piperidine-1- carbonyl)picolinamide::US10377742, Compound 419::US9663496, Compound 419	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328281	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328281&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710774	384573208							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817099	CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H33N5O5S/c1-42(39,40)28-9-5-25(6-10-28)35-16-12-24(13-17-35)34-30(37)23-4-11-29(33-21-23)31(38)36-18-14-27(15-19-36)41-26-7-2-22(20-32)3-8-26/h2-11,21,24,27H,12-19H2,1H3,(H,34,37)	RWRQJVGLXNKXAI-UHFFFAOYSA-N	328282	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- (methylsulfonyl)phenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 420::US9663496, Compound 420	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328282	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328282&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710859	384573209							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817100	CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1	InChI=1S/C30H34FN5O4S/c1-41(39,40)27-9-7-26(8-10-27)35-14-12-25(13-15-35)33-29(37)23-4-11-28(32-20-23)30(38)36-18-16-34(17-19-36)21-22-2-5-24(31)6-3-22/h2-11,20,25H,12-19,21H2,1H3,(H,33,37)	BOMYFXTYBRETRO-UHFFFAOYSA-N	409395	6-(4-(4-fluorobenzyl)piperazine-1- carbonyl)-N-(1-(4- (methylsulfonyl)phenyl)piperidin-4- yl)nicotinamide::US10377742, Compound 421	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409395&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710800	406790971							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817101	Fc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C30H30FN5O3/c31-23-4-6-25(7-5-23)35-15-11-24(12-16-35)34-29(37)22-3-10-28(33-20-22)30(38)36-17-13-27(14-18-36)39-26-8-1-21(19-32)2-9-26/h1-10,20,24,27H,11-18H2,(H,34,37)	HLZSPWLRXQTEHF-UHFFFAOYSA-N	328284	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorophenyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 422::US9663496, Compound 422	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328284&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710510	384573211							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817102	COc1ccc(cc1)N1CCC(CC1)NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N	InChI=1S/C31H33N5O4/c1-39-26-9-5-25(6-10-26)35-16-12-24(13-17-35)34-30(37)23-4-11-29(33-21-23)31(38)36-18-14-28(15-19-36)40-27-7-2-22(20-32)3-8-27/h2-11,21,24,28H,12-19H2,1H3,(H,34,37)	XDHLQPZDWFLLBX-UHFFFAOYSA-N	328285	6-(4-(4-cyanophenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxyphenyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 423::US9663496, Compound 423	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328285	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328285&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710327	384573212							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817103	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cccc(OC(F)(F)F)c2)CC1	InChI=1S/C33H35F3N4O5/c1-44-27-8-5-23(6-9-27)30(41)24-11-17-40(18-12-24)32(43)29-10-7-25(20-37-29)31(42)38-26-13-15-39(16-14-26)21-22-3-2-4-28(19-22)45-33(34,35)36/h2-10,19-20,24,26H,11-18,21H2,1H3,(H,38,42)	DRTNBWSDTRSDFI-UHFFFAOYSA-N	328286	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 424::US9663496, Compound 424	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328286	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328286&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710273	384573213							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817104	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2cccc(OC)c2)CC1	InChI=1S/C33H38N4O5/c1-41-28-9-6-24(7-10-28)31(38)25-12-18-37(19-13-25)33(40)30-11-8-26(21-34-30)32(39)35-27-14-16-36(17-15-27)22-23-4-3-5-29(20-23)42-2/h3-11,20-21,25,27H,12-19,22H2,1-2H3,(H,35,39)	FIFRYWRXSPZTJD-UHFFFAOYSA-N	328287	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(3-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 425::US9663496, Compound 425	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328287	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328287&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710603	384573214							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817105	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2cc(C)on2)C[C@@H]1F	InChI=1S/C30H34FN5O5/c1-19-15-23(34-41-19)17-35-12-11-26(25(31)18-35)33-29(38)22-5-8-27(32-16-22)30(39)36-13-9-21(10-14-36)28(37)20-3-6-24(40-2)7-4-20/h3-8,15-16,21,25-26H,9-14,17-18H2,1-2H3,(H,33,38)/t25-,26+/m0/s1	HJLLFICFQXAIAT-IZZNHLLZSA-N	409400	N-((3S,4R)-3-fluoro-1-((5-methylisoxazol- 3-yl)methyl)piperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 426	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409400&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652036	406790976							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817106	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2csc(C)n2)C[C@@H]1F	InChI=1S/C30H34FN5O4S/c1-19-33-23(18-41-19)16-35-12-11-26(25(31)17-35)34-29(38)22-5-8-27(32-15-22)30(39)36-13-9-21(10-14-36)28(37)20-3-6-24(40-2)7-4-20/h3-8,15,18,21,25-26H,9-14,16-17H2,1-2H3,(H,34,38)/t25-,26+/m0/s1	QECRHJAQOQEILO-IZZNHLLZSA-N	409401	N-((3S,4R)-3-fluoro-1-((2-methylthiazol-4- yl)methyl)piperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 427	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409401	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409401&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652037	406790977							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817107	CC(=O)Nc1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)cc1	InChI=1S/C33H36F3N5O5/c1-22(42)38-25-6-8-27(9-7-25)45-28-13-17-41(18-14-28)32(44)30-10-5-24(20-37-30)31(43)39-26-11-15-40(16-12-26)21-23-3-2-4-29(19-23)46-33(34,35)36/h2-10,19-20,26,28H,11-18,21H2,1H3,(H,38,42)(H,39,43)	NXUARYUTSSUSSG-UHFFFAOYSA-N	328290	6-(4-(4- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 428::US9663496, Compound 428	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328290	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328290&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710593	384573217							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817108	CC(=O)Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c1	InChI=1S/C33H36F3N5O5/c1-22(42)38-26-5-3-6-28(19-26)45-27-12-16-41(17-13-27)32(44)30-9-8-24(20-37-30)31(43)39-25-10-14-40(15-11-25)21-23-4-2-7-29(18-23)46-33(34,35)36/h2-9,18-20,25,27H,10-17,21H2,1H3,(H,38,42)(H,39,43)	HJAZSWLXYPIMTM-UHFFFAOYSA-N	328291	6-(4-(3- acetamidophenoxy)  piperidine-1-carbonyl)- N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 429::US9663496, Compound 429	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328291	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328291&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710419	384573218							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817109	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C33H35F3N4O5/c1-44-27-9-4-23(5-10-27)30(41)24-12-18-40(19-13-24)32(43)29-11-6-25(20-37-29)31(42)38-26-14-16-39(17-15-26)21-22-2-7-28(8-3-22)45-33(34,35)36/h2-11,20,24,26H,12-19,21H2,1H3,(H,38,42)	ZWIGVNWZHBPXNS-UHFFFAOYSA-N	328292	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 430::US9663496, Compound 430	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328292	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328292&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710324	384573219							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817110	O=C(Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c1)C1CC1	InChI=1S/C35H38N6O4/c36-21-24-4-6-25(7-5-24)23-40-16-12-28(13-17-40)38-34(43)27-10-11-32(37-22-27)35(44)41-18-14-30(15-19-41)45-31-3-1-2-29(20-31)39-33(42)26-8-9-26/h1-7,10-11,20,22,26,28,30H,8-9,12-19,23H2,(H,38,43)(H,39,42)	HWRKUDAALZUHQC-UHFFFAOYSA-N	328293	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(cyclopropane- carboxamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 431::US9663496, Compound 431	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328293	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328293&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710338	384573220							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817111	Fc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C34H38FN5O4/c35-26-9-4-23(5-10-26)22-39-16-12-27(13-17-39)37-33(42)25-8-11-31(36-21-25)34(43)40-18-14-29(15-19-40)44-30-3-1-2-28(20-30)38-32(41)24-6-7-24/h1-5,8-11,20-21,24,27,29H,6-7,12-19,22H2,(H,37,42)(H,38,41)	QSFYVVXENQIVBX-UHFFFAOYSA-N	328294	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4- fluorobenzyl)piperidin- 4-yl)nicotinamide::US10377742, Compound 432::US9663496, Compound 432	5'-AMP-activated protein kinase catalytic subunit alpha-2					 750					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328294	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328294&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710656	384573221							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817112	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3cccc(NC(=O)C4CC4)c3)cn2)cc1	InChI=1S/C33H30FN5O5/c34-23-7-10-26(11-8-23)44-30-13-9-25(20-36-30)38-32(41)22-6-12-29(35-19-22)33(42)39-16-14-27(15-17-39)43-28-3-1-2-24(18-28)37-31(40)21-4-5-21/h1-3,6-13,18-21,27H,4-5,14-17H2,(H,37,40)(H,38,41)	QGTOSURPTIGUOB-UHFFFAOYSA-N	328295	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 433::US9663496, Compound 433	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328295	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328295&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710484	384573222							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817113	O=C(Nc1cccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)N[C@H]2CC[C@H](CC2)Oc2ccc(cc2)C#N)c1)C1CC1	InChI=1S/C35H37N5O5/c36-21-23-4-11-28(12-5-23)44-29-13-9-26(10-14-29)38-34(42)25-8-15-32(37-22-25)35(43)40-18-16-30(17-19-40)45-31-3-1-2-27(20-31)39-33(41)24-6-7-24/h1-5,8,11-12,15,20,22,24,26,29-30H,6-7,9-10,13-14,16-19H2,(H,38,42)(H,39,41)/t26-,29+	JKWVHOJBLXODFV-RWDNANMHSA-N	409408	N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(3- (cyclopropanecarboxamido)phenoxy) piperidine-1-carbonyl)nicotinamide::US10377742, Compound 434	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409408&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710583	406790984							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817114	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C35H41N5O5/c1-44-29-10-5-24(6-11-29)23-39-17-13-27(14-18-39)37-34(42)26-9-12-32(36-22-26)35(43)40-19-15-30(16-20-40)45-31-4-2-3-28(21-31)38-33(41)25-7-8-25/h2-6,9-12,21-22,25,27,30H,7-8,13-20,23H2,1H3,(H,37,42)(H,38,41)	OUBRCHVVTYPJMB-UHFFFAOYSA-N	328297	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 435::US9663496, Compound 435	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328297	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328297&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710433	384573224							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817115	FC(F)(F)Sc1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H31F3N6O3S/c32-31(33,34)44-26-7-5-24(6-8-26)43-25-13-17-40(18-14-25)30(42)28-10-9-27(37-38-28)29(41)36-23-11-15-39(16-12-23)20-22-3-1-21(19-35)2-4-22/h1-10,23,25H,11-18,20H2,(H,36,41)	PKZHINNMONLOBK-UHFFFAOYSA-N	328298	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethylthio)  phenoxy)piperidine-1- carbonyl)pyridazine-3- carboxamide::US10377742, Compound 436::US9663496, Compound 436	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328298	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328298&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710813	384573225							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817116	CC(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H34N6O4/c1-22(39)25-6-8-27(9-7-25)42-28-14-18-38(19-15-28)32(41)30-11-10-29(35-36-30)31(40)34-26-12-16-37(17-13-26)21-24-4-2-23(20-33)3-5-24/h2-11,26,28H,12-19,21H2,1H3,(H,34,40)	ACJLYGUYLHGBRM-UHFFFAOYSA-N	328299	6-(4-(4-acetylphenoxy)  piperidine-1-carbonyl)- N-(1-(4- cyanobenzyl)piperidin-4- yl)pyridazine-3- carboxamide::US10377742, Compound 437::US9663496, Compound 437	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328299	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328299&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710739	384573226							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817117	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2cccc(NC(=O)C3CC3)c2)cc1	InChI=1S/C35H38F3N5O5/c36-35(37,38)48-29-9-4-23(5-10-29)22-42-16-12-26(13-17-42)40-33(45)25-8-11-31(39-21-25)34(46)43-18-14-28(15-19-43)47-30-3-1-2-27(20-30)41-32(44)24-6-7-24/h1-5,8-11,20-21,24,26,28H,6-7,12-19,22H2,(H,40,45)(H,41,44)	ZEJJGUPFZSMWAX-UHFFFAOYSA-N	328300	6-(4-(3-(cyclopropane- carboxamido)phenoxy)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 438::US9663496, Compound 438	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328300	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328300&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710754	384573227							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817118	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C36H43N5O4/c1-45-32-11-4-26(5-12-32)25-39-20-16-30(17-21-39)38-35(43)29-8-13-33(37-24-29)36(44)41-22-14-28(15-23-41)34(42)27-6-9-31(10-7-27)40-18-2-3-19-40/h4-13,24,28,30H,2-3,14-23,25H2,1H3,(H,38,43)	LLRSNVNZYTWKPN-UHFFFAOYSA-N	328301	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 439::US9663496, Compound 439	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328301	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328301&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710531	384573228							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817119	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-10-3-25(4-11-31)24-42-19-15-29(16-20-42)41-34(46)28-7-12-32(40-23-28)35(47)44-21-13-27(14-22-44)33(45)26-5-8-30(9-6-26)43-17-1-2-18-43/h3-12,23,27,29H,1-2,13-22,24H2,(H,41,46)	CYFFRIPWULCMAW-UHFFFAOYSA-N	328302	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 440::US9663496, Compound 440	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328302	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328302&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710384	384573229							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817120	FC(F)(F)Oc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)c1	InChI=1S/C36H40F3N5O4/c37-36(38,39)48-31-5-3-4-25(22-31)24-42-18-14-29(15-19-42)41-34(46)28-8-11-32(40-23-28)35(47)44-20-12-27(13-21-44)33(45)26-6-9-30(10-7-26)43-16-1-2-17-43/h3-11,22-23,27,29H,1-2,12-21,24H2,(H,41,46)	IRZRWLCHLOQQMF-UHFFFAOYSA-N	328303	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(3- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 441::US9663496, Compound 441	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328303&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710467	384573230							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817121	O=C(N[C@H]1CC[C@H](CC1)Oc1ccc(cc1)C#N)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C36H39N5O4/c37-23-25-3-12-31(13-4-25)45-32-14-8-29(9-15-32)39-35(43)28-7-16-33(38-24-28)36(44)41-21-17-27(18-22-41)34(42)26-5-10-30(11-6-26)40-19-1-2-20-40/h3-7,10-13,16,24,27,29,32H,1-2,8-9,14-15,17-22H2,(H,39,43)/t29-,32+	PWNFGRQMNJTNJN-OGWCZJSDSA-N	409416	N-((cis)-4-(4-cyanophenoxy)cyclohexyl)-6- (4-(4-(pyrrolidin-1-yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 442	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409416&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710659	406790992							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817122	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1F	InChI=1S/C36H42FN5O4/c1-46-33-11-4-25(22-31(33)37)24-40-18-14-29(15-19-40)39-35(44)28-7-10-32(38-23-28)36(45)42-20-12-27(13-21-42)34(43)26-5-8-30(9-6-26)41-16-2-3-17-41/h4-11,22-23,27,29H,2-3,12-21,24H2,1H3,(H,39,44)	FKPPDDDQZXPHNG-UHFFFAOYSA-N	328305	N-(1-(3-fluoro-4- methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 443::US9663496, Compound 443	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328305	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328305&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710480	384573232							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817123	O=C(NC1CCN(Cc2ccc(cc2)N2CCCC2)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(cc1)N1CCCC1	InChI=1S/C39H48N6O3/c46-37(30-7-12-35(13-8-30)44-21-3-4-22-44)31-15-25-45(26-16-31)39(48)36-14-9-32(27-40-36)38(47)41-33-17-23-42(24-18-33)28-29-5-10-34(11-6-29)43-19-1-2-20-43/h5-14,27,31,33H,1-4,15-26,28H2,(H,41,47)	GTYRGADELCISQB-UHFFFAOYSA-N	328306	6-(4-(4-(pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)-N-(1-(4- (pyrrolidin-1- yl)benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 444::US9663496, Compound 444	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328306	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328306&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710698	384573233							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817124	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCNCC1	InChI=1S/C25H30N4O4/c1-33-21-5-2-17(3-6-21)23(30)18-10-14-29(15-11-18)25(32)22-7-4-19(16-27-22)24(31)28-20-8-12-26-13-9-20/h2-7,16,18,20,26H,8-15H2,1H3,(H,28,31)	JEZQAPKFUPHGQX-UHFFFAOYSA-N	328307	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(piperidin-4- yl)nicotinamide::US10377742, Compound 445::US9663496, Compound 445	5'-AMP-activated protein kinase catalytic subunit alpha-2					>10000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328307	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328307&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710471	384573234							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817125	CC(C)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)cc1	InChI=1S/C38H47N5O4/c1-27(2)47-34-12-5-28(6-13-34)26-41-21-17-32(18-22-41)40-37(45)31-9-14-35(39-25-31)38(46)43-23-15-30(16-24-43)36(44)29-7-10-33(11-8-29)42-19-3-4-20-42/h5-14,25,27,30,32H,3-4,15-24,26H2,1-2H3,(H,40,45)	HUMCBAOVNNNRNA-UHFFFAOYSA-N	328308	N-(1-(4- isopropoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pyrrolidin-1- yl)benzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 446::US9663496, Compound 446	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328308	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328308&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710454	384573235							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817126	Fc1cc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(cc2)N2CCCC2)ccc1C#N	InChI=1S/C36H39FN6O3/c37-32-21-25(3-4-28(32)22-38)24-41-17-13-30(14-18-41)40-35(45)29-7-10-33(39-23-29)36(46)43-19-11-27(12-20-43)34(44)26-5-8-31(9-6-26)42-15-1-2-16-42/h3-10,21,23,27,30H,1-2,11-20,24H2,(H,40,45)	LQGICZMHJVYZGC-UHFFFAOYSA-N	328309	N-(1-(4-cyano-3- fluorobenzyl)piperidin- 4-yl)-6-(4-(4-(pyrrolidin- 1-yl)benzoyl)piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 447::US9663496, Compound 447	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328309	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328309&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710475	384573236							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817127	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(NS(=O)(=O)C2CC2)cc1	InChI=1S/C34H38N6O5S/c35-21-24-1-3-25(4-2-24)23-39-17-13-27(14-18-39)37-33(41)26-5-12-32(36-22-26)34(42)40-19-15-30(16-20-40)45-29-8-6-28(7-9-29)38-46(43,44)31-10-11-31/h1-9,12,22,27,30-31,38H,10-11,13-20,23H2,(H,37,41)	CLJBRWCXTFMREC-UHFFFAOYSA-N	328310	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (cyclopropane- sulfonamido)phenoxy)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 448::US9663496, Compound 448	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328310	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328310&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710476	384573237							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817128	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(NS(=O)(=O)C4CC4)cc3)cn2)cc1	InChI=1S/C32H30FN5O6S/c33-22-2-7-26(8-3-22)44-30-14-6-24(20-35-30)36-31(39)21-1-13-29(34-19-21)32(40)38-17-15-27(16-18-38)43-25-9-4-23(5-10-25)37-45(41,42)28-11-12-28/h1-10,13-14,19-20,27-28,37H,11-12,15-18H2,(H,36,39)	WYUCTYJNLHAUHO-UHFFFAOYSA-N	328311	6-(4-(4-(cyclopropane- sulfonamido)phenoxy)  piperidine-1-carbonyl)- N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 449::US9663496, Compound 449	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328311	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328311&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710599	384573238							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817129	FC(F)(F)S(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C32H32F3N5O5S/c33-32(34,35)46(43,44)28-8-6-26(7-9-28)45-27-13-17-40(18-14-27)31(42)29-10-5-24(20-37-29)30(41)38-25-11-15-39(16-12-25)21-23-3-1-22(19-36)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,38,41)	XVUVHIMZDREIIH-UHFFFAOYSA-N	328312	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (trifluoromethylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 450::US9663496, Compound 450	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328312	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328312&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710750	384573239							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817130	F[C@@H]1CN(Cc2ccc(cc2)C#N)CC[C@H]1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)S(=O)(=O)C(F)(F)F	InChI=1S/C32H31F4N5O5S/c33-27-20-40(19-22-3-1-21(17-37)2-4-22)14-13-28(27)39-30(42)23-5-10-29(38-18-23)31(43)41-15-11-25(12-16-41)46-24-6-8-26(9-7-24)47(44,45)32(34,35)36/h1-10,18,25,27-28H,11-16,19-20H2,(H,39,42)/t27-,28-/m1/s1	BFKLKEDGPVUXEU-VSGBNLITSA-N	409425	N-((trans)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-6-(4-(4- (trifluoromethylsulfonyl)phenoxy) piperidine- 1-carbonyl)nicotinamide::US10377742, Compound 451	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409425&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710383	406791000							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817131	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m1/s1	LEUSDRGCPVXECX-FQLXRVMXSA-N	328314	N-((3R,4R)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 452::US9663496, Compound 452	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328314	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328314&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652376	384573241							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817132	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29-/m0/s1	LEUSDRGCPVXECX-VMPREFPWSA-N	328315	N-((3S,4S)-1-(4- cyanobenzyl)-3- fluoropiperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 453::US9663496, Compound 453	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328315	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328315&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652377	384573242							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817133	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(cc2)C#N)C[C@@H]1F	InChI=1S/C33H34FN5O4/c1-43-27-9-6-24(7-10-27)31(40)25-12-16-39(17-13-25)33(42)30-11-8-26(19-36-30)32(41)37-29-14-15-38(21-28(29)34)20-23-4-2-22(18-35)3-5-23/h2-11,19,25,28-29H,12-17,20-21H2,1H3,(H,37,41)/t28-,29+/m0/s1	LEUSDRGCPVXECX-URLMMPGGSA-N	409428	N-((cis)-1-(4-cyanobenzyl)-3- fluoropiperidin-4-yl)-6-(4-(4- methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 454	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409428&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710444	406791003							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817134	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1	InChI=1S/C35H37F3N4O5/c36-35(37,38)47-30-8-1-23(2-9-30)22-41-17-13-27(14-18-41)40-33(44)26-7-12-31(39-21-26)34(45)42-19-15-29(16-20-42)46-28-10-5-25(6-11-28)32(43)24-3-4-24/h1-2,5-12,21,24,27,29H,3-4,13-20,22H2,(H,40,44)	VUYRMWJLJSPEAR-UHFFFAOYSA-N	328317	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 455::US9663496, Compound 455	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328317	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328317&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710635	384573244							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817135	O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(nc1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C(=O)C1CC1	InChI=1S/C35H37N5O4/c36-21-24-1-3-25(4-2-24)23-39-17-13-29(14-18-39)38-34(42)28-9-12-32(37-22-28)35(43)40-19-15-31(16-20-40)44-30-10-7-27(8-11-30)33(41)26-5-6-26/h1-4,7-12,22,26,29,31H,5-6,13-20,23H2,(H,38,42)	RSAGGDQJRANTFF-UHFFFAOYSA-N	328318	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 456::US9663496, Compound 456	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328318	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328318&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710518	384573245							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817136	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)C(=O)C3CC3)cn2)cc1	InChI=1S/C33H29FN4O5/c34-24-6-11-27(12-7-24)43-30-14-8-25(20-36-30)37-32(40)23-5-13-29(35-19-23)33(41)38-17-15-28(16-18-38)42-26-9-3-22(4-10-26)31(39)21-1-2-21/h3-14,19-21,28H,1-2,15-18H2,(H,37,40)	YWDIAISASAOPKH-UHFFFAOYSA-N	328319	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(6-(4- fluorophenoxy)pyridin- 3-yl)nicotinamide::US10377742, Compound 457::US9663496, Compound 457	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328319	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328319&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710580	384573246							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817137	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)C(=O)C2CC2)cc1	InChI=1S/C35H40N4O5/c1-43-29-9-2-24(3-10-29)23-38-18-14-28(15-19-38)37-34(41)27-8-13-32(36-22-27)35(42)39-20-16-31(17-21-39)44-30-11-6-26(7-12-30)33(40)25-4-5-25/h2-3,6-13,22,25,28,31H,4-5,14-21,23H2,1H3,(H,37,41)	KHGJLNGHJFLLLE-UHFFFAOYSA-N	328320	6-(4-(4- (cyclopropanecarbonyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 458::US9663496, Compound 458	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328320&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710705	384573247							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817138	CS(=O)(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C31H27N5O6S/c1-43(39,40)27-10-8-24(9-11-27)41-26-14-16-36(17-15-26)31(38)28-12-4-22(19-33-28)30(37)35-23-5-13-29(34-20-23)42-25-6-2-21(18-32)3-7-25/h2-13,19-20,26H,14-17H2,1H3,(H,35,37)	ZZTBEWMJLPGORM-UHFFFAOYSA-N	328321	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- (methylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 459::US9663496, Compound 459	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328321&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710354	384573248							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817139	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1	InChI=1S/C32H27N5O5/c1-41-26-10-4-22(5-11-26)30(38)23-14-16-37(17-15-23)32(40)28-12-6-24(19-34-28)31(39)36-25-7-13-29(35-20-25)42-27-8-2-21(18-33)3-9-27/h2-13,19-20,23H,14-17H2,1H3,(H,36,39)	NMTSURTYCYXFAT-UHFFFAOYSA-N	328322	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 460::US9663496, Compound 460	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328322&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710330	384573249							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817140	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N[C@@H]1CCN(Cc2ccc(OC(F)(F)F)cc2)C[C@@H]1F	InChI=1S/C33H34F4N4O5/c1-45-25-9-4-22(5-10-25)30(42)23-12-16-41(17-13-23)32(44)29-11-6-24(18-38-29)31(43)39-28-14-15-40(20-27(28)34)19-21-2-7-26(8-3-21)46-33(35,36)37/h2-11,18,23,27-28H,12-17,19-20H2,1H3,(H,39,43)/t27-,28+/m0/s1	HWOSDYNCBXZMQP-WUFINQPMSA-N	409435	N-((cis)-3-fluoro-1-(4- (trifluoromethoxy)benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 461	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409435&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710689	406791010							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817141	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(C)=O)nc1	InChI=1S/C33H30N4O6/c1-21(38)22-3-11-28(12-4-22)43-30-14-8-26(20-35-30)36-32(40)25-7-13-29(34-19-25)33(41)37-17-15-24(16-18-37)31(39)23-5-9-27(42-2)10-6-23/h3-14,19-20,24H,15-18H2,1-2H3,(H,36,40)	GVYSRPMXFBVISQ-UHFFFAOYSA-N	328324	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 462::US9663496, Compound 462	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328324&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710437	384573251							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817142	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)c(F)c1	InChI=1S/C31H23F2N5O4/c32-22-4-8-25(26(33)15-22)29(39)20-11-13-38(14-12-20)31(41)27-9-3-21(17-35-27)30(40)37-23-5-10-28(36-18-23)42-24-6-1-19(16-34)2-7-24/h1-10,15,17-18,20H,11-14H2,(H,37,40)	MBGUZCQMFZFQCG-UHFFFAOYSA-N	328325	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 463::US9663496, Compound 463	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328325&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710502	384573252							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817143	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C32H26F2N4O5/c1-19(39)20-2-7-25(8-3-20)43-29-11-6-24(18-36-29)37-31(41)22-4-10-28(35-17-22)32(42)38-14-12-21(13-15-38)30(40)26-9-5-23(33)16-27(26)34/h2-11,16-18,21H,12-15H2,1H3,(H,37,41)	GKRIJBBPXCVYRF-UHFFFAOYSA-N	328326	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 464::US9663496, Compound 464	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328326&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710457	384573253							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817144	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)S(C)(=O)=O)nc1	InChI=1S/C32H30N4O7S/c1-42-25-7-3-21(4-8-25)30(37)22-15-17-36(18-16-22)32(39)28-13-5-23(19-33-28)31(38)35-24-6-14-29(34-20-24)43-26-9-11-27(12-10-26)44(2,40)41/h3-14,19-20,22H,15-18H2,1-2H3,(H,35,38)	WWMWPFIHGSDSJL-UHFFFAOYSA-N	328327	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(6-(4-(methylsulfonyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 465::US9663496, Compound 465	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328327&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710641	384573254							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817145	CS(=O)(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C31H26F2N4O6S/c1-44(41,42)24-7-5-23(6-8-24)43-28-11-4-22(18-35-28)36-30(39)20-2-10-27(34-17-20)31(40)37-14-12-19(13-15-37)29(38)25-9-3-21(32)16-26(25)33/h2-11,16-19H,12-15H2,1H3,(H,36,39)	YJVUDJAYUHJDRZ-UHFFFAOYSA-N	328328	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4-(methylsulfonyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 466::US9663496, Compound 466	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328328&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710342	384573255							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817146	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(nc1)S(=O)(=O)c1ccc(F)cc1	InChI=1S/C31H27FN4O6S/c1-42-25-8-2-20(3-9-25)29(37)21-14-16-36(17-15-21)31(39)27-12-4-22(18-33-27)30(38)35-24-7-13-28(34-19-24)43(40,41)26-10-5-23(32)6-11-26/h2-13,18-19,21H,14-17H2,1H3,(H,35,38)	HSERFCLBNQCVPF-UHFFFAOYSA-N	328329	N-(6-(4- fluorophenylsulfonyl)  pyridin-3-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 467::US9663496, Compound 467	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328329&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710512	384573256							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817147	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)cn1	InChI=1S/C32H27N5O5/c1-41-25-9-4-22(5-10-25)30(38)23-14-16-37(17-15-23)32(40)28-12-6-24(19-34-28)31(39)36-29-13-11-27(20-35-29)42-26-7-2-21(18-33)3-8-26/h2-13,19-20,23H,14-17H2,1H3,(H,35,36,39)	MHVPPJHUAXVIGF-UHFFFAOYSA-N	328330	N-(5-(4- cyanophenoxy)pyridin- 2-yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 468::US9663496, Compound 468	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328330&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710779	384573257							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817148	Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)cn2)c(F)c1	InChI=1S/C31H23F2N5O4/c32-22-4-8-25(26(33)15-22)29(39)20-11-13-38(14-12-20)31(41)27-9-3-21(17-35-27)30(40)37-28-10-7-24(18-36-28)42-23-5-1-19(16-34)2-6-23/h1-10,15,17-18,20H,11-14H2,(H,36,37,40)	OWQAWPLCNSFMKM-UHFFFAOYSA-N	328331	N-(5-(4- cyanophenoxy)pyridin- 2-yl)-6-(4-(2,4- difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 469::US9663496, Compound 469	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328331&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710425	384573258							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817149	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C31H32F4N4O5S/c32-23-4-8-26(9-5-23)45(42,43)27-13-17-39(18-14-27)30(41)28-10-3-22(19-36-28)29(40)37-24-11-15-38(16-12-24)20-21-1-6-25(7-2-21)44-31(33,34)35/h1-10,19,24,27H,11-18,20H2,(H,37,40)	KCEAIMNCDQJEOH-UHFFFAOYSA-N	328332	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 470::US9663496, Compound 470	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328332&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710597	384573259							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817150	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C31H32FN5O4S/c32-25-6-8-27(9-7-25)42(40,41)28-13-17-37(18-14-28)31(39)29-10-5-24(20-34-29)30(38)35-26-11-15-36(16-12-26)21-23-3-1-22(19-33)2-4-23/h1-10,20,26,28H,11-18,21H2,(H,35,38)	JZZXYUGABUNNTJ-UHFFFAOYSA-N	328333	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 471::US9663496, Compound 471	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328333&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710702	384573260							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817151	Fc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1	InChI=1S/C30H24FN5O5S/c31-22-4-9-25(10-5-22)42(39,40)26-13-15-36(16-14-26)30(38)27-11-3-21(18-33-27)29(37)35-23-6-12-28(34-19-23)41-24-7-1-20(17-32)2-8-24/h1-12,18-19,26H,13-16H2,(H,35,37)	ZPVFVTXUAVUJPB-UHFFFAOYSA-N	328334	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 472::US9663496, Compound 472	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328334&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710808	384573261							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817152	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)S(=O)(=O)c3ccc(F)cc3)cn2)cc1	InChI=1S/C31H27FN4O6S/c1-20(37)21-2-8-25(9-3-21)42-29-13-7-24(19-34-29)35-30(38)22-4-12-28(33-18-22)31(39)36-16-14-27(15-17-36)43(40,41)26-10-5-23(32)6-11-26/h2-13,18-19,27H,14-17H2,1H3,(H,35,38)	NWALXLHJGKSUHI-UHFFFAOYSA-N	328335	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- fluorophenylsulfonyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 473::US9663496, Compound 473	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328335&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710515	384573262							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817153	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)S(=O)(=O)c2ccc(F)cc2)cc1	InChI=1S/C31H35FN4O5S/c1-41-26-7-2-22(3-8-26)21-35-16-12-25(13-17-35)34-30(37)23-4-11-29(33-20-23)31(38)36-18-14-28(15-19-36)42(39,40)27-9-5-24(32)6-10-27/h2-11,20,25,28H,12-19,21H2,1H3,(H,34,37)	JRJGDHLBBROFNB-UHFFFAOYSA-N	328336	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 474::US9663496, Compound 474	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328336&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710632	384573263							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817154	COc1cccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)S(=O)(=O)c2ccc(F)cc2)c1	InChI=1S/C31H35FN4O5S/c1-41-26-4-2-3-22(19-26)21-35-15-11-25(12-16-35)34-30(37)23-5-10-29(33-20-23)31(38)36-17-13-28(14-18-36)42(39,40)27-8-6-24(32)7-9-27/h2-10,19-20,25,28H,11-18,21H2,1H3,(H,34,37)	DMPDJUBALZCJMN-UHFFFAOYSA-N	328337	6-(4-(4- fluorophenylsulfonyl)  piperidine-1-carbonyl)- N-(1-(3-methoxybenzyl)  piperidin-4- yl)nicotinamide::US10377742, Compound 475::US9663496, Compound 475	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328337	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328337&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710592	384573264							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817155	Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H25FN6O3/c31-24-6-1-22(2-7-24)20-36-13-15-37(16-14-36)30(39)27-11-5-23(18-33-27)29(38)35-25-8-12-28(34-19-25)40-26-9-3-21(17-32)4-10-26/h1-12,18-19H,13-16,20H2,(H,35,38)	LFRYTBJZABLZSQ-UHFFFAOYSA-N	328338	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 476::US9663496, Compound 476	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328338	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328338&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710556	384573265							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817156	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCN(Cc4ccc(F)cc4)CC3)cn2)cc1	InChI=1S/C31H28FN5O4/c1-21(38)23-4-10-27(11-5-23)41-29-13-9-26(19-34-29)35-30(39)24-6-12-28(33-18-24)31(40)37-16-14-36(15-17-37)20-22-2-7-25(32)8-3-22/h2-13,18-19H,14-17,20H2,1H3,(H,35,39)	UUWVSSXXHKEBGA-UHFFFAOYSA-N	328339	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)nicotinamide::US10377742, Compound 477::US9663496, Compound 477	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328339&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710616	384573266							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817157	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C#N)nc1C	InChI=1S/C33H29N5O5/c1-21-28(13-14-30(36-21)43-27-8-3-22(19-34)4-9-27)37-32(40)25-7-12-29(35-20-25)33(41)38-17-15-24(16-18-38)31(39)23-5-10-26(42-2)11-6-23/h3-14,20,24H,15-18H2,1-2H3,(H,37,40)	YOZDAUSMDOLDJM-UHFFFAOYSA-N	328340	N-(6-(4-cyanophenoxy)- 2-methylpyridin-3-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 478::US9663496, Compound 478	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328340&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710622	384573267							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817158	Cc1nc(Oc2ccc(cc2)C#N)ccc1NC(=O)c1ccc(nc1)C(=O)N1CCC(CC1)C(=O)c1ccc(F)cc1F	InChI=1S/C32H25F2N5O4/c1-19-27(10-11-29(37-19)43-24-6-2-20(17-35)3-7-24)38-31(41)22-4-9-28(36-18-22)32(42)39-14-12-21(13-15-39)30(40)25-8-5-23(33)16-26(25)34/h2-11,16,18,21H,12-15H2,1H3,(H,38,41)	FGKOOCQTYBWAPY-UHFFFAOYSA-N	328341	N-(6-(4-cyanophenoxy)- 2-methylpyridin-3-yl)-6- (4-(2,4-difluorobenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 479::US9663496, Compound 479	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328341&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710669	384573268							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817159	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(=O)N(C)C)nc1	InChI=1S/C34H33N5O6/c1-38(2)33(42)24-6-12-28(13-7-24)45-30-15-9-26(21-36-30)37-32(41)25-8-14-29(35-20-25)34(43)39-18-16-23(17-19-39)31(40)22-4-10-27(44-3)11-5-22/h4-15,20-21,23H,16-19H2,1-3H3,(H,37,41)	HIHGKUXVUVLGOQ-UHFFFAOYSA-N	328342	N-(6-(4- (dimethylcarbamoyl)  phenoxy)pyridin-3-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 480::US9663496, Compound 480	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328342&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710595	384573269							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817160	CN(C)C(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)C(=O)c3ccc(F)cc3F)cn2)cc1	InChI=1S/C33H29F2N5O5/c1-39(2)32(43)21-3-8-25(9-4-21)45-29-12-7-24(19-37-29)38-31(42)22-5-11-28(36-18-22)33(44)40-15-13-20(14-16-40)30(41)26-10-6-23(34)17-27(26)35/h3-12,17-20H,13-16H2,1-2H3,(H,38,42)	CSMZDTSEHGVTML-UHFFFAOYSA-N	328343	6-(4-(2,4- difluorobenzoyl)  piperidine-1-carbonyl)- N-(6-(4- (dimethylcarbamoyl)  phenoxy)pyridin-3- yl)nicotinamide::US10377742, Compound 481::US9663496, Compound 481	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328343&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710329	384573270							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817161	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N(C)C1CCN(Cc2ccc(cc2)C#N)CC1	InChI=1S/C34H37N5O4/c1-37(29-15-17-38(18-16-29)23-25-5-3-24(21-35)4-6-25)33(41)28-9-12-31(36-22-28)34(42)39-19-13-27(14-20-39)32(40)26-7-10-30(43-2)11-8-26/h3-12,22,27,29H,13-20,23H2,1-2H3	FRYJAPPODQHJRU-UHFFFAOYSA-N	328344	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1-carbonyl)- N-methylnicotinamide::US10377742, Compound 482::US9663496, Compound 482	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328344&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710664	384573271							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817162	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)N(C)C1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1	InChI=1S/C34H37F3N4O5/c1-39(27-15-17-40(18-16-27)22-23-3-8-29(9-4-23)46-34(35,36)37)32(43)26-7-12-30(38-21-26)33(44)41-19-13-25(14-20-41)31(42)24-5-10-28(45-2)11-6-24/h3-12,21,25,27H,13-20,22H2,1-2H3	MEOATWALOAIMIC-UHFFFAOYSA-N	328345	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-methyl-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 483::US9663496, Compound 483	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328345&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710720	384573272							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817163	COc1ccc(CN2CCC(CC2)N(C)C(=O)c2ccc(nc2)C(=O)N2CCC(CC2)C(=O)c2ccc(OC)cc2)cc1	InChI=1S/C34H40N4O5/c1-36(28-16-18-37(19-17-28)23-24-4-9-29(42-2)10-5-24)33(40)27-8-13-31(35-22-27)34(41)38-20-14-26(15-21-38)32(39)25-6-11-30(43-3)12-7-25/h4-13,22,26,28H,14-21,23H2,1-3H3	HHOJNLQASSTSAG-UHFFFAOYSA-N	328346	6-(4-(4-methoxybenzoyl)  piperidine-1-carbonyl)- N-(1-(4-methoxybenzyl)  piperidin-4-yl)-N- methylnicotinamide::US10377742, Compound 484::US9663496, Compound 484	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328346&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710662	384573273							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817164	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(C)cc3)cn2)cc1	InChI=1S/C32H30N4O5/c1-21-3-9-26(10-4-21)40-28-15-17-36(18-16-28)32(39)29-13-7-24(19-33-29)31(38)35-25-8-14-30(34-20-25)41-27-11-5-23(6-12-27)22(2)37/h3-14,19-20,28H,15-18H2,1-2H3,(H,35,38)	PAIRWBQYWPIOKM-UHFFFAOYSA-N	409459	N-(6-(4-acetylphenoxy)pyridin-3-yl)-6-(4- (4-(methylsulfonyl)phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 485	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409459&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676217	406791034							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817165	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(=O)(=O)C3CC3)cn2)cc1	InChI=1S/C34H32N4O7S/c1-22(39)23-2-6-27(7-3-23)45-32-15-5-25(21-36-32)37-33(40)24-4-14-31(35-20-24)34(41)38-18-16-28(17-19-38)44-26-8-10-29(11-9-26)46(42,43)30-12-13-30/h2-11,14-15,20-21,28,30H,12-13,16-19H2,1H3,(H,37,40)	MAJDJUWLOQSGFM-UHFFFAOYSA-N	328348	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (cyclopropylsulfonyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 486::US9663496, Compound 486	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328348&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710579	384573275							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817166	CC(=O)c1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCN(CC3)c3ccc(C)cc3)cn2)cc1	InChI=1S/C31H29N5O4/c1-21-3-9-26(10-4-21)35-15-17-36(18-16-35)31(39)28-13-7-24(19-32-28)30(38)34-25-8-14-29(33-20-25)40-27-11-5-23(6-12-27)22(2)37/h3-14,19-20H,15-18H2,1-2H3,(H,34,38)	YDHXJIHQYNMLIF-UHFFFAOYSA-N	409461	N-(6-(4-acetylphenoxy)pyridin-3-yl)-6-(4- (4-(methylsulfonyl)phenyl)piperazine-1- carbonyl)nicotinamide::US10377742, Compound 487	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409461&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676218	406791036							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817167	CN(C)C(=O)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C(C)=O)nc2)cc1	InChI=1S/C34H33N5O6/c1-22(40)23-4-10-28(11-5-23)45-31-15-9-26(21-36-31)37-32(41)25-8-14-30(35-20-25)34(43)39-18-16-29(17-19-39)44-27-12-6-24(7-13-27)33(42)38(2)3/h4-15,20-21,29H,16-19H2,1-3H3,(H,37,41)	IDAXHXKLJMZMTG-UHFFFAOYSA-N	328350	N-(6-(4- acetylphenoxy)pyridin- 3-yl)-6-(4-(4- (dimethylcarbamoyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 488::US9663496, Compound 488	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328350	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328350&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710520	384573277							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817168	CC(C)c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(cn1)C(=O)Nc1ccc(Oc2ccc(cc2)C(C)=O)nc1	InChI=1S/C33H33N5O4/c1-22(2)24-4-10-28(11-5-24)37-16-18-38(19-17-37)33(41)30-14-8-26(20-34-30)32(40)36-27-9-15-31(35-21-27)42-29-12-6-25(7-13-29)23(3)39/h4-15,20-22H,16-19H2,1-3H3,(H,36,40)	ATXVRIMQWFAQOK-UHFFFAOYSA-N	409463	N-(6-(4-acetylphenoxy)pyridin-3-yl)-6-(4- (4-(isopropylsulfonyl)phenyl)piperazine-1- carbonyl)nicotinamide::US10377742, Compound 489	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409463&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			146676219	406791038							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817169	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C(=O)N(C)C)CC1	InChI=1S/C35H41N5O5/c1-38(2)34(43)27-6-4-24(5-7-27)23-39-18-16-29(17-19-39)37-33(42)28-10-13-31(36-22-28)35(44)40-20-14-26(15-21-40)32(41)25-8-11-30(45-3)12-9-25/h4-13,22,26,29H,14-21,23H2,1-3H3,(H,37,42)	MJFMCJRNWDTCIF-UHFFFAOYSA-N	328352	N-(1-(4- (dimethylcarbamoyl)  benzyl)piperidin-4-yl)-6- (4-(4-methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 490::US9663496, Compound 490	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328352&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			66710509	384573279							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817170	Fc1ccc(CN2CCN(CC2)c2ccc(nn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C29H32FN7O/c30-25-7-5-24(6-8-25)21-36-15-17-37(18-16-36)28-10-9-27(33-34-28)29(38)32-26-11-13-35(14-12-26)20-23-3-1-22(19-31)2-4-23/h1-10,26H,11-18,20-21H2,(H,32,38)	PDHJZIQJMYUJNZ-UHFFFAOYSA-N	328353	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- fluorobenzyl)piperazin- 1-yl)pyridazine-3- carboxamide::US10377742, Compound 491::US9663496, Compound 491	5'-AMP-activated protein kinase catalytic subunit alpha-2					 3000					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328353&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			58073206	384573280							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817171	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F5N5O3S/c32-45(33,34,35,36)28-8-6-26(7-9-28)44-27-13-17-41(18-14-27)31(43)24-5-10-29(38-20-24)30(42)39-25-11-15-40(16-12-25)21-23-3-1-22(19-37)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,39,42)	BAQNKGBJRYOBKF-UHFFFAOYSA-N	328354	N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)picolinamide::US10377742, Compound 492::US9663496, Compound 492	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328354&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119980	384573281							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817172	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1	InChI=1S/C31H32F5N5O3S/c32-45(33,34,35,36)28-8-6-26(7-9-28)44-27-13-17-41(18-14-27)31(43)29-10-5-24(20-38-29)30(42)39-25-11-15-40(16-12-25)21-23-3-1-22(19-37)2-4-23/h1-10,20,25,27H,11-18,21H2,(H,39,42)	YQNDTFLKFFIKOY-UHFFFAOYSA-N	328355	N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 493::US9663496, Compound 493	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328355&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119968	384573282							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817173	FC(F)(F)Oc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(F)(F)(F)(F)F)cc1	InChI=1S/C31H32F8N4O4S/c32-31(33,34)47-26-4-1-21(2-5-26)20-42-15-11-23(12-16-42)41-29(44)22-3-10-28(40-19-22)30(45)43-17-13-25(14-18-43)46-24-6-8-27(9-7-24)48(35,36,37,38)39/h1-10,19,23,25H,11-18,20H2,(H,41,44)	IRXMWPNSDLENHP-UHFFFAOYSA-N	328356	6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)-N-(1-(4- (trifluoromethoxy)  benzyl)piperidin-4- yl)nicotinamide::US10377742, Compound 494::US9663496, Compound 494	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328356&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652378	384573283							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817174	COc1ccc(CN2CCC(CC2)NC(=O)c2ccc(nc2)C(=O)N2CCC(CC2)Oc2ccc(cc2)S(F)(F)(F)(F)F)cc1	InChI=1S/C31H35F5N4O4S/c1-43-25-5-2-22(3-6-25)21-39-16-12-24(13-17-39)38-30(41)23-4-11-29(37-20-23)31(42)40-18-14-27(15-19-40)44-26-7-9-28(10-8-26)45(32,33,34,35)36/h2-11,20,24,27H,12-19,21H2,1H3,(H,38,41)	MZWKXTIWRUKNLP-UHFFFAOYSA-N	328357	N-(1-(4-methoxybenzyl)  piperidin-4-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 495::US9663496, Compound 495	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328357	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328357&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119908	384573284							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817175	Fc1ccc(Oc2ccc(NC(=O)c3ccc(nc3)C(=O)N3CCC(CC3)Oc3ccc(cc3)S(F)(F)(F)(F)F)cn2)cc1	InChI=1S/C29H24F6N4O4S/c30-20-2-5-23(6-3-20)43-27-12-4-21(18-37-27)38-28(40)19-1-11-26(36-17-19)29(41)39-15-13-24(14-16-39)42-22-7-9-25(10-8-22)44(31,32,33,34)35/h1-12,17-18,24H,13-16H2,(H,38,40)	BPLWMEIZMICBAU-UHFFFAOYSA-N	328358	N-(6-(4- fluorophenoxy)pyridin- 3-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 496::US9663496, Compound 496	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328358&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119984	384573285							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817176	FS(F)(F)(F)(F)c1ccc(OC2CCN(CC2)C(=O)c2ccc(cn2)C(=O)Nc2ccc(Oc3ccc(cc3)C#N)nc2)cc1	InChI=1S/C30H24F5N5O4S/c31-45(32,33,34,35)26-9-7-23(8-10-26)43-25-13-15-40(16-14-25)30(42)27-11-3-21(18-37-27)29(41)39-22-4-12-28(38-19-22)44-24-5-1-20(17-36)2-6-24/h1-12,18-19,25H,13-16H2,(H,39,41)	GEWONQLQWOVJJA-UHFFFAOYSA-N	328359	N-(6-(4- cyanophenoxy)pyridin- 3-yl)-6-(4-(4- (pentafluorosulfanyl)  phenoxy)piperidine-1- carbonyl)nicotinamide::US10377742, Compound 497::US9663496, Compound 497	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328359&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			87119930	384573286							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
817177	COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1(F)F	InChI=1S/C33H33F2N5O4/c1-44-27-9-6-24(7-10-27)30(41)25-12-16-40(17-13-25)32(43)28-11-8-26(19-37-28)31(42)38-29-14-15-39(21-33(29,34)35)20-23-4-2-22(18-36)3-5-23/h2-11,19,25,29H,12-17,20-21H2,1H3,(H,38,42)	GLKJXMSLKUEYGJ-UHFFFAOYSA-N	328360	N-(1-(4-cyanobenzyl)- 3,3-difluoropiperidin-4- yl)-6-(4-(4- methoxybenzoyl)  piperidine-1- carbonyl)nicotinamide::US10377742, Compound 498::US9663496, Compound 498	5'-AMP-activated protein kinase catalytic subunit alpha-2					<500					US Patent		10.7270/Q2RV0R22		aid1803740	US10377742	Goff, D; Payan, D; Singh, R; Shaw, S; Carroll, D; Hitoshi, Y	Rigel Pharmaceuticals, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328360&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			56652379	384573287							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51234789	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F	InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1	OSVUGUHRKMMBSE-INMRTLOZSA-N	50505542	CHEMBL4576489	5'-AMP-activated protein kinase catalytic subunit alpha-2				 46						ChEMBL	10.1016/j.bmcl.2019.126641	10.7270/Q2RV0S0K	31526603			Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M	Takeda Pharmaceutical Company Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505542&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			155552127	440714127							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51234804	CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F	InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1	NXSJMRCTGYTSTK-SQHKIPTKSA-N	50505541	CHEMBL4465866	5'-AMP-activated protein kinase catalytic subunit alpha-2				 45						ChEMBL	10.1016/j.bmcl.2019.126641	10.7270/Q2RV0S0K	31526603			Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M	Takeda Pharmaceutical Company Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505541&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			155531579	440714126							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51272747	CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1	InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32)	WVGDUQVQWLHVEA-UHFFFAOYSA-N	50519662	CHEMBL4438748	5'-AMP-activated protein kinase catalytic subunit alpha-2			>10000							ChEMBL	10.1021/acs.jmedchem.9b01143	10.7270/Q2MC93FG	31693351			Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S	TBA	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			155513187	440728244							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
1025337	CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccccc23)c2ccccc2)cc1	InChI=1S/C29H31N5O2/c1-32-16-18-34(19-17-32)20-26(35)33(2)23-14-12-22(13-15-23)30-28(21-8-4-3-5-9-21)27-24-10-6-7-11-25(24)31-29(27)36/h3-15,30H,16-20H2,1-2H3,(H,31,36)/b28-27-	FCLPVPNWFDOVKL-DQSJHHFOSA-N	50248946	CHEMBL1908392::US10981896, Compound 16	5'-AMP-activated protein kinase catalytic subunit alpha-2		 4.20								US Patent		10.7270/Q24X5BWV		aid1805467	US10981896	Dalby, KN; Edupuganti, R; Taliaferro, J; Lee, JH	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248946&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			136242661	104103407							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
1025338	COC(=O)c1ccc2NC(=O)\C(=C(/Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c2c1	InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-19-22(31(39)40-3)9-14-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-	WGWCRXQUBYJTRA-ZIADKAODSA-N	50248937	CHEMBL4062168::US10981896, Compound 15	5'-AMP-activated protein kinase catalytic subunit alpha-2		 9.20								US Patent		10.7270/Q24X5BWV		aid1805467	US10981896	Dalby, KN; Edupuganti, R; Taliaferro, J; Lee, JH	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248937&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			137248544	401961437							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
1025339	CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccc(cc23)C(O)=O)c2ccccc2)cc1	InChI=1S/C30H31N5O4/c1-33-14-16-35(17-15-33)19-26(36)34(2)23-11-9-22(10-12-23)31-28(20-6-4-3-5-7-20)27-24-18-21(30(38)39)8-13-25(24)32-29(27)37/h3-13,18,31H,14-17,19H2,1-2H3,(H,32,37)(H,38,39)/b28-27-	NOMBUNHXDWBICV-DQSJHHFOSA-N	50248938	CHEMBL4089284::US10981896, Compound 21	5'-AMP-activated protein kinase catalytic subunit alpha-2		 4.90								US Patent		10.7270/Q24X5BWV		aid1805467	US10981896	Dalby, KN; Edupuganti, R; Taliaferro, J; Lee, JH	BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248938&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			137301774	401961438							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397229	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WINHZLLDWRZWRT-ATVHPVEESA-N	4814	CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248	5'-AMP-activated protein kinase catalytic subunit alpha-2			 62							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	B49	6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD	5329102	8034462	38940	CHEMBL535	DB01268	5713		ZINC03964325	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397230	Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN	InChI=1S/C18H19FN4O2/c1-9-15(22-10(2)16(9)18(25)21-6-5-20)8-13-12-7-11(19)3-4-14(12)23-17(13)24/h3-4,7-8,22H,5-6,20H2,1-2H3,(H,21,25)(H,23,24)/b13-8-	MUXSMSOGTBJZDC-JYRVWZFOSA-N	50564445	CHEMBL3542333	5'-AMP-activated protein kinase catalytic subunit alpha-2			 141							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564445&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			11221549	461684783							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397231	CN(C)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C20H23FN4O2/c1-11-17(23-12(2)18(11)20(27)22-7-8-25(3)4)10-15-14-9-13(21)5-6-16(14)24-19(15)26/h5-6,9-10,23H,7-8H2,1-4H3,(H,22,27)(H,24,26)/b15-10-	MBTDIENWIYANIG-GDNBJRDFSA-N	4817	N-[2-(dimethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248 analog 12e	5'-AMP-activated protein kinase catalytic subunit alpha-2			 50							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4817&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			5329105	8034465						ZINC13493833	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397232	CCNCCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-	LIZNIAKSBJKPQC-GDNBJRDFSA-N	50564446	CHEMBL3542344	5'-AMP-activated protein kinase catalytic subunit alpha-2			 61							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564446&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			10292573	461684784							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397233	CN(C)CCCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C21H25FN4O2/c1-12-18(11-16-15-10-14(22)6-7-17(15)25-20(16)27)24-13(2)19(12)21(28)23-8-5-9-26(3)4/h6-7,10-11,24H,5,8-9H2,1-4H3,(H,23,28)(H,25,27)/b16-11-	CBVYRMZAJKSDGJ-WJDWOHSUSA-N	50564447	CHEMBL4799580	5'-AMP-activated protein kinase catalytic subunit alpha-2			 75							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564447&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162677234	461684785							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397234	CCN(CC)CCCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C	InChI=1S/C23H29FN4O2/c1-5-28(6-2)11-7-10-25-23(30)21-14(3)20(26-15(21)4)13-18-17-12-16(24)8-9-19(17)27-22(18)29/h8-9,12-13,26H,5-7,10-11H2,1-4H3,(H,25,30)(H,27,29)/b18-13-	MLSDVCJXCYFKAJ-AQTBWJFISA-N	50564448	CHEMBL4788980	5'-AMP-activated protein kinase catalytic subunit alpha-2			 39							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564448	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564448&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			71157876	461684786							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397235	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C	InChI=1S/C22H28N4O2/c1-5-26(6-2)12-11-23-22(28)20-14(3)19(24-15(20)4)13-17-16-9-7-8-10-18(16)25-21(17)27/h7-10,13,24H,5-6,11-12H2,1-4H3,(H,23,28)(H,25,27)/b17-13-	UJGXTMZILSGDLG-LGMDPLHJSA-N	4813	N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxamide::SU11248 analog 12a	5'-AMP-activated protein kinase catalytic subunit alpha-2			 89							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4813&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			5329101	8034461						ZINC13493831	1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397236	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3cc(F)ccc23)c1C	InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)18(25-14(20)4)12-17-16-8-7-15(23)11-19(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	HCSLNMZYDZLMOP-ATVHPVEESA-N	50564449	CHEMBL4779166	5'-AMP-activated protein kinase catalytic subunit alpha-2			 49							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564449	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564449&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162662723	461684787							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397237	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3cc(Cl)ccc23)c1C	InChI=1S/C22H27ClN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)18(25-14(20)4)12-17-16-8-7-15(23)11-19(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	JPQIKBXALJNAKG-ATVHPVEESA-N	50564450	CHEMBL4786972	5'-AMP-activated protein kinase catalytic subunit alpha-2			 65							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564450	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564450&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162668027	461684788							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397238	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3cc(Br)ccc23)c1C	InChI=1S/C22H27BrN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)18(25-14(20)4)12-17-16-8-7-15(23)11-19(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-	WNDUJGBGBDASMN-ATVHPVEESA-N	50564451	CHEMBL4782796	5'-AMP-activated protein kinase catalytic subunit alpha-2			 83							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564451	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564451&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162664768	461684789							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397239	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(cc23)C#N)c1C	InChI=1S/C23H27N5O2/c1-5-28(6-2)10-9-25-23(30)21-14(3)20(26-15(21)4)12-18-17-11-16(13-24)7-8-19(17)27-22(18)29/h7-8,11-12,26H,5-6,9-10H2,1-4H3,(H,25,30)(H,27,29)/b18-12-	MHRSBLMFDBDIOU-PDGQHHTCSA-N	50564453	CHEMBL4794096	5'-AMP-activated protein kinase catalytic subunit alpha-2			 16							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564453&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162673400	461684791							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397240	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CNC(N)=O)cc23)c1C	InChI=1S/C24H32N6O3/c1-5-30(6-2)10-9-26-23(32)21-14(3)20(28-15(21)4)12-18-17-11-16(13-27-24(25)33)7-8-19(17)29-22(18)31/h7-8,11-12,28H,5-6,9-10,13H2,1-4H3,(H,26,32)(H,29,31)(H3,25,27,33)/b18-12-	ZSSGLTYUJFFIAZ-PDGQHHTCSA-N	50564454	CHEMBL4792246	5'-AMP-activated protein kinase catalytic subunit alpha-2			 84							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564454&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162671464	461684792							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397241	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCOC)cc23)c1C	InChI=1S/C25H34N4O3/c1-6-29(7-2)12-11-26-25(31)23-16(3)22(27-17(23)4)15-20-19-14-18(10-13-32-5)8-9-21(19)28-24(20)30/h8-9,14-15,27H,6-7,10-13H2,1-5H3,(H,26,31)(H,28,30)/b20-15-	GRRWNPDZXOTJNA-HKWRFOASSA-N	50564455	CHEMBL4781062	5'-AMP-activated protein kinase catalytic subunit alpha-2			 97							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564455&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162662373	461684793							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397242	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCOC(C)=O)cc23)c1C	InChI=1S/C26H34N4O4/c1-6-30(7-2)12-11-27-26(33)24-16(3)23(28-17(24)4)15-21-20-14-19(10-13-34-18(5)31)8-9-22(20)29-25(21)32/h8-9,14-15,28H,6-7,10-13H2,1-5H3,(H,27,33)(H,29,32)/b21-15-	NICPYYDKEPDTPW-QNGOZBTKSA-N	50564456	CHEMBL4799631	5'-AMP-activated protein kinase catalytic subunit alpha-2			 111							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564456&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162676568	461684794							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397243	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCO)cc23)c1C	InChI=1S/C24H32N4O3/c1-5-28(6-2)11-10-25-24(31)22-15(3)21(26-16(22)4)14-19-18-13-17(9-12-29)7-8-20(18)27-23(19)30/h7-8,13-14,26,29H,5-6,9-12H2,1-4H3,(H,25,31)(H,27,30)/b19-14-	HTVNZZYDHQNFBS-RGEXLXHISA-N	50564457	CHEMBL4800500	5'-AMP-activated protein kinase catalytic subunit alpha-2			 21							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564457&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162676482	461684795							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397244	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC#N)cc23)c1C	InChI=1S/C25H31N5O2/c1-5-30(6-2)13-12-27-25(32)23-16(3)22(28-17(23)4)15-20-19-14-18(8-7-11-26)9-10-21(19)29-24(20)31/h9-10,14-15,28H,5-8,12-13H2,1-4H3,(H,27,32)(H,29,31)/b20-15-	PIPKBPQXMOCACO-HKWRFOASSA-N	50564458	CHEMBL4788376	5'-AMP-activated protein kinase catalytic subunit alpha-2			 32							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564458&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162669908	461684796							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397245	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC(N)=O)cc23)c1C	InChI=1S/C25H33N5O3/c1-5-30(6-2)12-11-27-25(33)23-15(3)21(28-16(23)4)14-19-18-13-17(8-10-22(26)31)7-9-20(18)29-24(19)32/h7,9,13-14,28H,5-6,8,10-12H2,1-4H3,(H2,26,31)(H,27,33)(H,29,32)/b19-14-	IQUHNNUWFFXNMM-RGEXLXHISA-N	50564459	CHEMBL4781578	5'-AMP-activated protein kinase catalytic subunit alpha-2			 61							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564459&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162664520	461684797							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397246	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCN(C)C)cc23)c1C	InChI=1S/C26H37N5O2/c1-7-31(8-2)14-12-27-26(33)24-17(3)23(28-18(24)4)16-21-20-15-19(11-13-30(5)6)9-10-22(20)29-25(21)32/h9-10,15-16,28H,7-8,11-14H2,1-6H3,(H,27,33)(H,29,32)/b21-16-	VBPDEHRSGBYGIY-PGMHBOJBSA-N	50564460	CHEMBL4779730	5'-AMP-activated protein kinase catalytic subunit alpha-2			 154							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564460&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162662393	461684798							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397247	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCNC(C)=O)cc23)c1C	InChI=1S/C26H35N5O3/c1-6-31(7-2)13-12-28-26(34)24-16(3)23(29-17(24)4)15-21-20-14-19(10-11-27-18(5)32)8-9-22(20)30-25(21)33/h8-9,14-15,29H,6-7,10-13H2,1-5H3,(H,27,32)(H,28,34)(H,30,33)/b21-15-	BZYRCHBRDGOULK-QNGOZBTKSA-N	50564461	CHEMBL4795330	5'-AMP-activated protein kinase catalytic subunit alpha-2			 108							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564461&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162673814	461684799							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43						
51397248	CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCN=[N+]=[N-])cc23)c1C	InChI=1S/C24H31N7O2/c1-5-31(6-2)12-11-26-24(33)22-15(3)21(28-16(22)4)14-19-18-13-17(9-10-27-30-25)7-8-20(18)29-23(19)32/h7-8,13-14,28H,5-6,9-12H2,1-4H3,(H,26,33)(H,29,32)/b19-14-	CYJLLGOOGFYAKL-RGEXLXHISA-N	50564462	CHEMBL4796639	5'-AMP-activated protein kinase catalytic subunit alpha-2			 101							ChEMBL	10.1016/j.ejmech.2020.112316	10.7270/Q2348Q5W	32334266			Matheson, CJ; Casalvieri, KA; Backos, DS; Minhajuddin, M; Jordan, CT; Reigan, P	University of Colorado Anschutz Medical Campus	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8886&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564462&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2&column=ki&startPg=0&Increment=50&submit=Search			162674555	461684800							1	MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR	2H6D,2LTU,4CFE,4CFF,5ISO	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2_HUMAN	P54646	Q9H1E8 Q9UD43