BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID of Ligand	PubChem SID of Ligand	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
366790	C[C@H]1SC(N)=N[C@]2(CO[C@@H](CF)C[C@@H]12)c1ccc(F)cc1F	InChI=1S/C15H17F3N2OS/c1-8-12-5-10(6-16)21-7-15(12,20-14(19)22-8)11-3-2-9(17)4-13(11)18/h2-4,8,10,12H,5-7H2,1H3,(H2,19,20)/t8-,10-,12+,15-/m1/s1	LRUAFSXDUNPHJT-WABIZIGASA-N	207625	US9260455, 1	Isoform D of Beta-secretase 1 (BACE-I-432)			 805					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207625&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507166	322058194							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366791	COC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C16H20F2N2O2S/c1-9-13-6-11(7-21-2)22-8-16(13,20-15(19)23-9)12-4-3-10(17)5-14(12)18/h3-5,9,11,13H,6-8H2,1-2H3,(H2,19,20)/t9-,11-,13+,16-/m1/s1	VWZBYKQRKVQAQK-QBTOZTBISA-N	50081643	CHEMBL3422240::US9260455, 2	Isoform D of Beta-secretase 1 (BACE-I-432)			 737					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081643&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507168	313074384		CHEMBL3422240					1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366792	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C14H16F2N2OS/c1-8-4-9-6-20-13(17)18-14(9,7-19-8)11-3-2-10(15)5-12(11)16/h2-3,5,8-9H,4,6-7H2,1H3,(H2,17,18)/t8-,9-,14-/m0/s1	OLZWOORXDWFBII-FZNYLWTLSA-N	50078349	CHEMBL3414707::US9260455, 3	Isoform D of Beta-secretase 1 (BACE-I-432)			 704					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078349&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507167	313073631		CHEMBL3414707					1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366793	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C(F)F)c1ccc(F)cc1F	InChI=1S/C14H14F4N2OS/c15-8-1-2-9(10(16)4-8)14-6-21-11(12(17)18)3-7(14)5-22-13(19)20-14/h1-2,4,7,11-12H,3,5-6H2,(H2,19,20)/t7-,11+,14-/m0/s1	JPLGMHYUAWBTII-OXSLBIJZSA-N	50078320	CHEMBL3414700::US9260455, 4	Isoform D of Beta-secretase 1 (BACE-I-432)			 672					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078320	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078320&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507165	103970916		CHEMBL3414700				ZINC06176176	1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366794	CCOC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H22F2N2O2S/c1-3-22-8-12-7-14-10(2)24-16(20)21-17(14,9-23-12)13-5-4-11(18)6-15(13)19/h4-6,10,12,14H,3,7-9H2,1-2H3,(H2,20,21)/t10-,12-,14+,17-/m1/s1	PSZBVAJZXDPBHP-SXRDFINZSA-N	207626	US9260455, 5	Isoform D of Beta-secretase 1 (BACE-I-432)			 613					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207626&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507169	322058195							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366795	CC(C)OC[C@H]1C[C@H]2[C@@H](C)SC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C18H24F2N2O2S/c1-10(2)23-8-13-7-15-11(3)25-17(21)22-18(15,9-24-13)14-5-4-12(19)6-16(14)20/h4-6,10-11,13,15H,7-9H2,1-3H3,(H2,21,22)/t11-,13-,15+,18-/m1/s1	WNSIJZXQJTZAPQ-JPHJHBEYSA-N	207627	US9260455, 6	Isoform D of Beta-secretase 1 (BACE-I-432)			 718					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=207627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=207627&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507383	322058196							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366796	CC(C)C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C17H22F2N2OS/c1-10(2)5-13-6-11-8-23-16(20)21-17(11,9-22-13)14-4-3-12(18)7-15(14)19/h3-4,7,10-11,13H,5-6,8-9H2,1-2H3,(H2,20,21)/t11-,13-,17-/m0/s1	KSUADMBOPPDFIC-BNLOLNQZSA-N	50078321	CHEMBL3414711::US9260455, 7	Isoform D of Beta-secretase 1 (BACE-I-432)			 118					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078321	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078321&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73388368	313073627		CHEMBL3414711					1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
366797	COC[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F	InChI=1S/C15H18F2N2O2S/c1-20-6-11-4-9-7-22-14(18)19-15(9,8-21-11)12-3-2-10(16)5-13(12)17/h2-3,5,9,11H,4,6-8H2,1H3,(H2,18,19)/t9-,11+,15-/m0/s1	AVYXEHSYNNACNZ-ISOBSLSZSA-N	50078324	CHEMBL3414708::US9260455, 8	Isoform D of Beta-secretase 1 (BACE-I-432)			 855					4.5	37.00 C	US Patent		10.7270/Q2GB22WN		aid1802266	US9260455	Brodney, MA; Beck, EM; Butler, CR; Davoren, JE	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078324&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			73507384	313073630		CHEMBL3414708					1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390401	NC1=N[C@]2(COCC[C@H]2CS1)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H19F3N4O3S/c21-15-3-1-12(26-17(28)16-4-2-13(8-25-16)30-18(22)23)7-14(15)20-10-29-6-5-11(20)9-31-19(24)27-20/h1-4,7-8,11,18H,5-6,9-10H2,(H2,24,27)(H,26,28)/t11-,20-/m0/s1	QRAMMCLVMBTOID-YBTHPKLGSA-N	223406	US9315520, Comparator 4::US9605007, Comparator 4	Isoform D of Beta-secretase 1 (BACE-I-432)			 9					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223406	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223406&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			45279898	336285274							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390402	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18?/m0/s1	ZLZUHACSRMOLLV-SKHBRDHGSA-N	223407	US9315520, 1-HCl	Isoform D of Beta-secretase 1 (BACE-I-432)			 31					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223407	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223407&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435362	336285275							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390403	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1cc(NC(=O)c2ccc(cn2)C#N)cs1	InChI=1S/C19H19N5O2S2/c1-11-4-13-8-28-18(21)24-19(13,10-26-11)16-5-14(9-27-16)23-17(25)15-3-2-12(6-20)7-22-15/h2-3,5,7,9,11,13H,4,8,10H2,1H3,(H2,21,24)(H,23,25)/t11-,13-,19-/m0/s1	YIXDWYJNAHJADD-BLWXERESSA-N	223408	US9315520, Comparator 5	Isoform D of Beta-secretase 1 (BACE-I-432)			 73					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223408&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118446134	336285276							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390404	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2coc(CF)n2)cs1	InChI=1S/C16H18FN5O3S2/c1-8-2-9-5-27-15(18)22-16(9,7-25-8)14-21-11(6-26-14)20-13(23)10-4-24-12(3-17)19-10/h4,6,8-9H,2-3,5,7H2,1H3,(H2,18,22)(H,20,23)/t8-,9-,16?/m0/s1	ABEZBNOKPIPPHW-IJLCECLYSA-N	223409	US9315520, 3	Isoform D of Beta-secretase 1 (BACE-I-432)			 7					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223409&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435383	336285277							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390405	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccn(n2)C(F)F)cs1	InChI=1S/C16H18F2N6O2S2/c1-8-4-9-5-28-15(19)22-16(9,7-26-8)13-21-11(6-27-13)20-12(25)10-2-3-24(23-10)14(17)18/h2-3,6,8-9,14H,4-5,7H2,1H3,(H2,19,22)(H,20,25)/t8-,9-,16?/m0/s1	RODMHPIORBBNPR-IJLCECLYSA-N	223410	US9315520, 4	Isoform D of Beta-secretase 1 (BACE-I-432)			 19					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223410&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435366	336285278							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390406	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccc(cn2)C#N)cs1	InChI=1S/C18H18N6O2S2/c1-10-4-12-7-28-17(20)24-18(12,9-26-10)16-23-14(8-27-16)22-15(25)13-3-2-11(5-19)6-21-13/h2-3,6,8,10,12H,4,7,9H2,1H3,(H2,20,24)(H,22,25)/t10-,12-,18?/m0/s1	TYNXFCODUDWTAD-NTMPORJMSA-N	223411	US9315520, 5	Isoform D of Beta-secretase 1 (BACE-I-432)			 22					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223411&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435404	336285279							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390407	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)cs1	InChI=1S/C16H17ClF2N6O2S2/c1-7-2-8-4-29-15(20)23-16(8,6-27-7)13-22-10(5-28-13)21-12(26)11-9(17)3-25(24-11)14(18)19/h3,5,7-8,14H,2,4,6H2,1H3,(H2,20,23)(H,21,26)/t7-,8-,16?/m0/s1	WKQPDCHFDUEQDH-UBJYMUIPSA-N	223412	US9315520, 6	Isoform D of Beta-secretase 1 (BACE-I-432)			 4					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223412&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435457	336285280							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390408	NC1=N[C@]2(CO[C@H](C[C@H]2CS1)C(F)(F)F)c1cc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C21H18F6N4O3S/c22-14-3-1-11(30-17(32)15-4-2-12(7-29-15)34-18(23)24)6-13(14)20-9-33-16(21(25,26)27)5-10(20)8-35-19(28)31-20/h1-4,6-7,10,16,18H,5,8-9H2,(H2,28,31)(H,30,32)/t10-,16+,20-/m0/s1	FLRLJQHWZJIQAA-OJTOOCJTSA-N	223413	US9315520, Comparator 6::US9605007, Comparator 6::US9744173, Comparator 6	Isoform D of Beta-secretase 1 (BACE-I-432)			 6					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223413	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223413&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			45278903	336285281							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390409	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccc(Cl)cn2)cs1	InChI=1S/C17H18ClN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17?/m0/s1	UFKMIVRYLMOXNT-IUPUIGEKSA-N	223414	US9315520, 7-HCl	Isoform D of Beta-secretase 1 (BACE-I-432)			 19					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223414	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223414&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435411	336285282							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390410	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2coc(n2)C(F)F)cs1	InChI=1S/C16H17F2N5O3S2/c1-7-2-8-4-28-15(19)23-16(8,6-26-7)14-22-10(5-27-14)21-12(24)9-3-25-13(20-9)11(17)18/h3,5,7-8,11H,2,4,6H2,1H3,(H2,19,23)(H,21,24)/t7-,8-,16?/m0/s1	JVQDIEFSJNEVEV-UBJYMUIPSA-N	223415	US9315520, 8	Isoform D of Beta-secretase 1 (BACE-I-432)			 11					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223415&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435521	336285283							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390411	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(F)cn2)cs1	InChI=1S/C17H18FN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17-/m0/s1	QQBRRRLRJBDPNK-YMNVWFMLSA-N	223322	US9315520, 9::US9605007, Example 9::US9744173, Example 9	Isoform D of Beta-secretase 1 (BACE-I-432)			 189					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223322	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223322&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435412	336285197							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390412	COc1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H20N6O3S2/c1-9-3-10-6-28-16(18)23-17(10,8-26-9)15-22-12(7-27-15)21-14(24)11-4-20-13(25-2)5-19-11/h4-5,7,9-10H,3,6,8H2,1-2H3,(H2,18,23)(H,21,24)/t9-,10-,17-/m0/s1	OWMWOBMERLAIGE-YMNVWFMLSA-N	223323	US9315520, 10::US9605007, Example 10::US9744173, Example 10	Isoform D of Beta-secretase 1 (BACE-I-432)			 536					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223323&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435506	336285198							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390413	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(CF)cn2)cs1	InChI=1S/C17H19FN6O2S2/c1-9-2-10-6-28-16(19)24-17(10,8-26-9)15-23-13(7-27-15)22-14(25)12-5-20-11(3-18)4-21-12/h4-5,7,9-10H,2-3,6,8H2,1H3,(H2,19,24)(H,22,25)/t9-,10-,17-/m0/s1	CBLCZFAAVKWPBF-YMNVWFMLSA-N	223324	US9315520, 11::US9605007, Example 11::US9744173, Example 11	Isoform D of Beta-secretase 1 (BACE-I-432)			 315					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223324	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223324&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435396	336285199							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390414	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(OCC(F)F)cn2)cs1	InChI=1S/C18H20F2N6O3S2/c1-9-2-10-6-31-17(21)26-18(10,8-29-9)16-25-13(7-30-16)24-15(27)11-3-23-14(4-22-11)28-5-12(19)20/h3-4,7,9-10,12H,2,5-6,8H2,1H3,(H2,21,26)(H,24,27)/t9-,10-,18-/m0/s1	MTELPMJTUUXMHL-RAALSFIWSA-N	223325	US9315520, 12::US9605007, Example 12::US9744173, Example 12	Isoform D of Beta-secretase 1 (BACE-I-432)			 280					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223325	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223325&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435479	336285200							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390415	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(F)cc2C)cs1	InChI=1S/C18H20FN5O2S2/c1-9-3-12(19)5-21-14(9)15(25)22-13-7-27-16(23-13)18-8-26-10(2)4-11(18)6-28-17(20)24-18/h3,5,7,10-11H,4,6,8H2,1-2H3,(H2,20,24)(H,22,25)/t10-,11-,18-/m0/s1	MKJNGYHYSXIWAW-FHGNATFXSA-N	223326	US9315520, 13::US9605007, Example 13::US9744173, Example 13	Isoform D of Beta-secretase 1 (BACE-I-432)			 90					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223326	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223326&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435617	336285201							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390416	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(F)cc2)cs1	InChI=1S/C18H19FN4O2S2/c1-10-6-12-7-27-17(20)23-18(12,9-25-10)16-22-14(8-26-16)21-15(24)11-2-4-13(19)5-3-11/h2-5,8,10,12H,6-7,9H2,1H3,(H2,20,23)(H,21,24)/t10-,12-,18-/m0/s1	BTGCUXLUENXMRM-RSNWOKGLSA-N	223327	US9315520, 14::US9605007, Example 14	Isoform D of Beta-secretase 1 (BACE-I-432)			 866					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223327	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223327&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435369	336285202							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390417	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(cn2)C(F)F)cs1	InChI=1S/C17H18F2N6O2S2/c1-8-2-9-5-29-16(20)25-17(9,7-27-8)15-24-12(6-28-15)23-14(26)11-4-21-10(3-22-11)13(18)19/h3-4,6,8-9,13H,2,5,7H2,1H3,(H2,20,25)(H,23,26)/t8-,9-,17-/m0/s1	JYZPKERPINZOAQ-GSRNSYJJSA-N	223328	US9315520, 15::US9605007, Example 15::US9744173, Example 15	Isoform D of Beta-secretase 1 (BACE-I-432)			 145					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223328	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223328&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435488	336285203							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390418	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(cn2)C(F)(F)F)cs1	InChI=1S/C17H17F3N6O2S2/c1-8-2-9-5-30-15(21)26-16(9,7-28-8)14-25-12(6-29-14)24-13(27)10-3-23-11(4-22-10)17(18,19)20/h3-4,6,8-9H,2,5,7H2,1H3,(H2,21,26)(H,24,27)/t8-,9-,16-/m0/s1	DQNJGYDIUVGGMU-BEPCFFQHSA-N	223329	US9315520, 16::US9605007, Example 16::US9744173, Example 16	Isoform D of Beta-secretase 1 (BACE-I-432)			 193					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223329&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435464	336285204							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390419	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(cn2)C(F)(F)F)cs1	InChI=1S/C18H18F3N5O2S2/c1-9-4-11-6-30-16(22)26-17(11,8-28-9)15-25-13(7-29-15)24-14(27)12-3-2-10(5-23-12)18(19,20)21/h2-3,5,7,9,11H,4,6,8H2,1H3,(H2,22,26)(H,24,27)/t9-,11-,17-/m0/s1	ZZHRZUNUORUAKI-NSTVUXKKSA-N	223330	US9315520, 17::US9605007, Example 17::US9744173, Example 17	Isoform D of Beta-secretase 1 (BACE-I-432)			 54					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223330	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223330&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435560	336285205							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390420	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(F)cc2F)cs1	InChI=1S/C17H17F2N5O2S2/c1-8-2-9-5-28-16(20)24-17(9,7-26-8)15-23-12(6-27-15)22-14(25)13-11(19)3-10(18)4-21-13/h3-4,6,8-9H,2,5,7H2,1H3,(H2,20,24)(H,22,25)/t8-,9-,17-/m0/s1	KPPHBCMVHQAEJD-GSRNSYJJSA-N	223331	US9315520, 18::US9605007, Example 18::US9744173, Example 18	Isoform D of Beta-secretase 1 (BACE-I-432)			 153					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223331	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223331&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435529	336285206							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390421	COc1ccc(nc1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C18H21N5O3S2/c1-10-5-11-7-28-17(19)23-18(11,9-26-10)16-22-14(8-27-16)21-15(24)13-4-3-12(25-2)6-20-13/h3-4,6,8,10-11H,5,7,9H2,1-2H3,(H2,19,23)(H,21,24)/t10-,11-,18-/m0/s1	FAOQHMUWUIPURU-FHGNATFXSA-N	223332	US9315520, 19::US9605007, Example 19::US9744173, Example 19	Isoform D of Beta-secretase 1 (BACE-I-432)			 259					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223332	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223332&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435601	336285207							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390422	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)(F)F)cn2)cs1	InChI=1S/C18H18F3N5O3S2/c1-9-4-10-6-31-16(22)26-17(10,8-28-9)15-25-13(7-30-15)24-14(27)12-3-2-11(5-23-12)29-18(19,20)21/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,22,26)(H,24,27)/t9-,10-,17-/m0/s1	JGHWELLXLGSIDW-YMNVWFMLSA-N	223333	US9315520, 20::US9605007, Example 20::US9744173, Example 20	Isoform D of Beta-secretase 1 (BACE-I-432)			 108					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223333	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223333&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435414	336285208							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390423	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cc2)cs1	InChI=1S/C19H20F2N4O3S2/c1-10-6-12-7-30-18(22)25-19(12,9-27-10)16-24-14(8-29-16)23-15(26)11-2-4-13(5-3-11)28-17(20)21/h2-5,8,10,12,17H,6-7,9H2,1H3,(H2,22,25)(H,23,26)/t10-,12-,19-/m0/s1	OPDKSXUPVRRQFC-DKHZXNSXSA-N	223334	US9315520, 21::US9605007, Example 21::US9744173, Example 21	Isoform D of Beta-secretase 1 (BACE-I-432)			 106					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223334	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223334&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435377	336285209							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390424	CC#CCOc1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C20H22N6O3S2/c1-3-4-5-28-16-8-22-14(7-23-16)17(27)24-15-10-30-18(25-15)20-11-29-12(2)6-13(20)9-31-19(21)26-20/h7-8,10,12-13H,5-6,9,11H2,1-2H3,(H2,21,26)(H,24,27)/t12-,13-,20-/m0/s1	VBTNLZCJDCSFOZ-QAJFTPDKSA-N	223335	US9315520, 22::US9605007, Example 22::US9744173, Example 22	Isoform D of Beta-secretase 1 (BACE-I-432)			 13					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223335	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223335&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435549	336285210							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390425	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cc3ccccn3n2)cs1	InChI=1S/C19H20N6O2S2/c1-11-6-12-8-29-18(20)23-19(12,10-27-11)17-22-15(9-28-17)21-16(26)14-7-13-4-2-3-5-25(13)24-14/h2-5,7,9,11-12H,6,8,10H2,1H3,(H2,20,23)(H,21,26)/t11-,12-,19-/m0/s1	CVBNXPCVRUETLV-ZKTNFTSUSA-N	223336	US9315520, 23::US9605007, Example 23::US9744173, Example 23	Isoform D of Beta-secretase 1 (BACE-I-432)			 1000					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223336	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223336&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435489	336285211							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390426	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccn(C)n2)cs1	InChI=1S/C16H20N6O2S2/c1-9-5-10-6-26-15(17)20-16(10,8-24-9)14-19-12(7-25-14)18-13(23)11-3-4-22(2)21-11/h3-4,7,9-10H,5-6,8H2,1-2H3,(H2,17,20)(H,18,23)/t9-,10-,16-/m0/s1	ODHPORBDAZCOFR-PUTJDCORSA-N	223337	US9315520, 24::US9605007, Example 24::US9744173, Example 24	Isoform D of Beta-secretase 1 (BACE-I-432)			 81					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223337	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223337&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435557	336285212							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390427	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(cn2)C(F)F)cs1	InChI=1S/C18H19F2N5O2S2/c1-9-4-11-6-29-17(21)25-18(11,8-27-9)16-24-13(7-28-16)23-15(26)12-3-2-10(5-22-12)14(19)20/h2-3,5,7,9,11,14H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,11-,18-/m0/s1	VODMRWRUUKHXBB-DNTLEWNLSA-N	223338	US9315520, 25::US9605007, Example 25::US9744173, Example 25	Isoform D of Beta-secretase 1 (BACE-I-432)			 74					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223338	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223338&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435434	336285213							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390428	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OCF)cn2)cs1	InChI=1S/C18H20FN5O3S2/c1-10-4-11-6-29-17(20)24-18(11,8-26-10)16-23-14(7-28-16)22-15(25)13-3-2-12(5-21-13)27-9-19/h2-3,5,7,10-11H,4,6,8-9H2,1H3,(H2,20,24)(H,22,25)/t10-,11-,18-/m0/s1	VEDHYWULCFLZLU-FHGNATFXSA-N	223339	US9315520, 26::US9605007, Example 26::US9744173, Example 26	Isoform D of Beta-secretase 1 (BACE-I-432)			 68					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223339	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223339&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435370	336285214							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390429	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2coc(n2)C2CC2)cs1	InChI=1S/C18H21N5O3S2/c1-9-4-11-6-28-17(19)23-18(11,8-26-9)16-22-13(7-27-16)21-14(24)12-5-25-15(20-12)10-2-3-10/h5,7,9-11H,2-4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,11-,18-/m0/s1	VFCAYPOLCRSWNC-DNTLEWNLSA-N	223340	US9315520, 27::US9605007, Example 27::US9744173, Example 27	Isoform D of Beta-secretase 1 (BACE-I-432)			 1310					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223340	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223340&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435408	336285215							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390430	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnccn2)cs1	InChI=1S/C16H18N6O2S2/c1-9-4-10-6-26-15(17)22-16(10,8-24-9)14-21-12(7-25-14)20-13(23)11-5-18-2-3-19-11/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,17,22)(H,20,23)/t9-,10-,16-/m0/s1	IKSLBTJLVKHCPK-PUTJDCORSA-N	223341	US9315520, 28::US9605007, Example 28::US9744173, Example 28	Isoform D of Beta-secretase 1 (BACE-I-432)			 647					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223341	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223341&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435554	336285216							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390431	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cn(C)nc2C)cs1	InChI=1S/C17H22N6O2S2/c1-9-4-11-6-27-16(18)21-17(11,8-25-9)15-20-13(7-26-15)19-14(24)12-5-23(3)22-10(12)2/h5,7,9,11H,4,6,8H2,1-3H3,(H2,18,21)(H,19,24)/t9-,11-,17-/m0/s1	AMFCYNCVUSEZKE-NSTVUXKKSA-N	223342	US9315520, 29::US9605007, Example 29::US9744173, Example 29	Isoform D of Beta-secretase 1 (BACE-I-432)			 1990					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223342	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223342&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435390	336285217							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390432	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cccnn2)cs1	InChI=1S/C16H18N6O2S2/c1-9-5-10-6-26-15(17)21-16(10,8-24-9)14-20-12(7-25-14)19-13(23)11-3-2-4-18-22-11/h2-4,7,9-10H,5-6,8H2,1H3,(H2,17,21)(H,19,23)/t9-,10-,16-/m0/s1	KQUUSQLBNZEBSG-PUTJDCORSA-N	223343	US9315520, 30::US9605007, Example 30::US9744173, Example 30	Isoform D of Beta-secretase 1 (BACE-I-432)			 2160					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223343	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223343&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435620	336285218							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390433	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cc(on2)C2CC2)cs1	InChI=1S/C18H21N5O3S2/c1-9-4-11-6-28-17(19)22-18(11,8-25-9)16-21-14(7-27-16)20-15(24)12-5-13(26-23-12)10-2-3-10/h5,7,9-11H,2-4,6,8H2,1H3,(H2,19,22)(H,20,24)/t9-,11-,18-/m0/s1	KENHHNMXVIAHLZ-DNTLEWNLSA-N	223344	US9315520, 31::US9605007, Example 31::US9744173, Example 31	Isoform D of Beta-secretase 1 (BACE-I-432)			 3820					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223344	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223344&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435580	336285219							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390434	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cc(on2)C(F)(F)F)cs1	InChI=1S/C16H16F3N5O3S2/c1-7-2-8-4-29-14(20)23-15(8,6-26-7)13-22-11(5-28-13)21-12(25)9-3-10(27-24-9)16(17,18)19/h3,5,7-8H,2,4,6H2,1H3,(H2,20,23)(H,21,25)/t7-,8-,15-/m0/s1	JYRNKTIZIIHCIG-VQLIFVOLSA-N	223345	US9315520, 32::US9605007, Example 32::US9744173, Example 32	Isoform D of Beta-secretase 1 (BACE-I-432)			 1400					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223345	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223345&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435419	336285220							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390435	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cn(cn2)C2CCC2)cs1	InChI=1S/C19H24N6O2S2/c1-11-5-12-7-29-18(20)24-19(12,9-27-11)17-23-15(8-28-17)22-16(26)14-6-25(10-21-14)13-3-2-4-13/h6,8,10-13H,2-5,7,9H2,1H3,(H2,20,24)(H,22,26)/t11-,12-,19-/m0/s1	ITYWKJYCAPJVMB-ZKTNFTSUSA-N	223346	US9315520, 33::US9605007, Example 33::US9744173, Example 33	Isoform D of Beta-secretase 1 (BACE-I-432)			 34100					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223346	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223346&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435373	336285221							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390436	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cc(nn2C)C2CCC2)cs1	InChI=1S/C20H26N6O2S2/c1-11-6-13-8-30-19(21)24-20(13,10-28-11)18-23-16(9-29-18)22-17(27)15-7-14(25-26(15)2)12-4-3-5-12/h7,9,11-13H,3-6,8,10H2,1-2H3,(H2,21,24)(H,22,27)/t11-,13-,20-/m0/s1	SSQFRZCBPFEOAS-LOOLNKMNSA-N	223347	US9315520, 34::US9605007, Example 34::US9744173, Example 34	Isoform D of Beta-secretase 1 (BACE-I-432)			 1480					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223347	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223347&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435514	336285222							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390437	COCc1cc(no1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H21N5O4S2/c1-9-3-10-6-28-16(18)21-17(10,8-25-9)15-20-13(7-27-15)19-14(23)12-4-11(5-24-2)26-22-12/h4,7,9-10H,3,5-6,8H2,1-2H3,(H2,18,21)(H,19,23)/t9-,10-,17-/m0/s1	WOYRAWQEJFVPFI-YMNVWFMLSA-N	223348	US9315520, 35::US9605007, Example 35::US9744173, Example 35	Isoform D of Beta-secretase 1 (BACE-I-432)			 5860					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223348	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223348&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435391	336285223							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390438	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(=O)n(C)c2)cs1	InChI=1S/C18H21N5O3S2/c1-10-5-12-7-28-17(19)22-18(12,9-26-10)16-21-13(8-27-16)20-15(25)11-3-4-14(24)23(2)6-11/h3-4,6,8,10,12H,5,7,9H2,1-2H3,(H2,19,22)(H,20,25)/t10-,12-,18-/m0/s1	IECQITLUAYZASQ-RSNWOKGLSA-N	223349	US9315520, 36::US9605007, Example 36::US9744173, Example 36	Isoform D of Beta-secretase 1 (BACE-I-432)			 1410					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223349	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223349&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435444	336285224							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390439	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OCC(F)F)cn2)cs1	InChI=1S/C19H21F2N5O3S2/c1-10-4-11-7-31-18(22)26-19(11,9-29-10)17-25-15(8-30-17)24-16(27)13-3-2-12(5-23-13)28-6-14(20)21/h2-3,5,8,10-11,14H,4,6-7,9H2,1H3,(H2,22,26)(H,24,27)/t10-,11-,19-/m0/s1	ZPUSXGOIEYOOMF-ADWYPQAOSA-N	223350	US9315520, 37::US9605007, Example 37::US9744173, Example 37	Isoform D of Beta-secretase 1 (BACE-I-432)			 485					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223350	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223350&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435462	336285225							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390440	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nc(C)oc2C(F)(F)F)cs1	InChI=1S/C17H18F3N5O3S2/c1-7-3-9-4-30-15(21)25-16(9,6-27-7)14-24-10(5-29-14)23-13(26)11-12(17(18,19)20)28-8(2)22-11/h5,7,9H,3-4,6H2,1-2H3,(H2,21,25)(H,23,26)/t7-,9-,16-/m0/s1	ASVFESAYRASUCE-VNNFXVPXSA-N	223351	US9315520, 38::US9605007, Example 38::US9744173, Example 38	Isoform D of Beta-secretase 1 (BACE-I-432)			 145					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223351	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223351&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435358	336285226							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390441	CCc1cc(C(=O)Nc2csc(n2)[C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)n(C)n1	InChI=1S/C18H24N6O2S2/c1-4-12-6-13(24(3)23-12)15(25)20-14-8-27-16(21-14)18-9-26-10(2)5-11(18)7-28-17(19)22-18/h6,8,10-11H,4-5,7,9H2,1-3H3,(H2,19,22)(H,20,25)/t10-,11-,18-/m0/s1	CGRINOQDQPTZNQ-FHGNATFXSA-N	223352	US9315520, 39::US9605007, Example 39::US9744173, Example 39	Isoform D of Beta-secretase 1 (BACE-I-432)			 369					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223352	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223352&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435438	336285227							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390442	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnn(C)n2)cs1	InChI=1S/C15H19N7O2S2/c1-8-3-9-5-26-14(16)20-15(9,7-24-8)13-19-11(6-25-13)18-12(23)10-4-17-22(2)21-10/h4,6,8-9H,3,5,7H2,1-2H3,(H2,16,20)(H,18,23)/t8-,9-,15-/m0/s1	ZYZWEQGTOMZDFU-UTEYVOQOSA-N	223353	US9315520, 40::US9605007, Example 40::US9744173, Example 40	Isoform D of Beta-secretase 1 (BACE-I-432)			 134					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223353	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223353&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435558	336285228							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390443	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cc(C)nn2C)cs1	InChI=1S/C17H22N6O2S2/c1-9-4-12(23(3)22-9)14(24)19-13-7-26-15(20-13)17-8-25-10(2)5-11(17)6-27-16(18)21-17/h4,7,10-11H,5-6,8H2,1-3H3,(H2,18,21)(H,19,24)/t10-,11-,17-/m0/s1	BFNZIGAGWOZILF-DINDLPBHSA-N	223354	US9315520, 41::US9605007, Example 41::US9744173, Example 41	Isoform D of Beta-secretase 1 (BACE-I-432)			 364					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223354	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223354&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435589	336285229							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390444	CCc1nc(co1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H21N5O3S2/c1-3-13-19-11(5-24-13)14(23)20-12-7-26-15(21-12)17-8-25-9(2)4-10(17)6-27-16(18)22-17/h5,7,9-10H,3-4,6,8H2,1-2H3,(H2,18,22)(H,20,23)/t9-,10-,17-/m0/s1	XCOKYPIHKSJERY-YMNVWFMLSA-N	223355	US9315520, 42::US9605007, Example 42::US9744173, Example 42	Isoform D of Beta-secretase 1 (BACE-I-432)			 341					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223355&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435425	336285230							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390445	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncn(C)n2)cs1	InChI=1S/C15H19N7O2S2/c1-8-3-9-4-26-14(16)20-15(9,6-24-8)13-19-10(5-25-13)18-12(23)11-17-7-22(2)21-11/h5,7-9H,3-4,6H2,1-2H3,(H2,16,20)(H,18,23)/t8-,9-,15-/m0/s1	XSHMGCWZBJZOJD-UTEYVOQOSA-N	223356	US9315520, 43::US9605007, Example 43::US9744173, Example 43	Isoform D of Beta-secretase 1 (BACE-I-432)			 435					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223356&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435544	336285231							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390446	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(C)(F)F)cn2)cs1	InChI=1S/C19H21F2N5O3S2/c1-10-5-11-7-31-17(22)26-19(11,9-28-10)16-25-14(8-30-16)24-15(27)13-4-3-12(6-23-13)29-18(2,20)21/h3-4,6,8,10-11H,5,7,9H2,1-2H3,(H2,22,26)(H,24,27)/t10-,11-,19-/m0/s1	VDCUDRLINVFMIC-ADWYPQAOSA-N	223357	US9315520, 44::US9605007, Example 44::US9744173, Example 44	Isoform D of Beta-secretase 1 (BACE-I-432)			 185					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223357	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223357&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435495	336285232							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390447	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F	InChI=1S/C20H20ClFN4O2S/c1-11-6-12-9-29-19(23)26-20(12,10-28-11)15-7-14(3-4-16(15)22)25-18(27)17-5-2-13(21)8-24-17/h2-5,7-8,11-12H,6,9-10H2,1H3,(H2,23,26)(H,25,27)/t11-,12-,20-/m0/s1	UOHXUSCZQJMWQO-PVUDRZGPSA-N	223358	US9315520, Comparator 7::US9605007, Comparator 7::US9744173, Comparator 7	Isoform D of Beta-secretase 1 (BACE-I-432)			 1					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223358	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223358&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			45279589	336285233							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390448	COc1cnc(C(=O)Nc2csc(n2)[C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)c(C)n1	InChI=1S/C18H22N6O3S2/c1-9-4-11-6-29-17(19)24-18(11,8-27-9)16-23-12(7-28-16)22-15(25)14-10(2)21-13(26-3)5-20-14/h5,7,9,11H,4,6,8H2,1-3H3,(H2,19,24)(H,22,25)/t9-,11-,18-/m0/s1	SXWPACCPHBMXRP-DNTLEWNLSA-N	223359	US9315520, 46::US9605007, Example 46::US9744173, Example 46	Isoform D of Beta-secretase 1 (BACE-I-432)			 320					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223359	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223359&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435507	336285234							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390449	COc1cnc(C(=O)Nc2csc(n2)[C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)c(C)c1	InChI=1S/C19H23N5O3S2/c1-10-4-13(26-3)6-21-15(10)16(25)22-14-8-28-17(23-14)19-9-27-11(2)5-12(19)7-29-18(20)24-19/h4,6,8,11-12H,5,7,9H2,1-3H3,(H2,20,24)(H,22,25)/t11-,12-,19-/m0/s1	NIJBHFCCBZSVIL-ZKTNFTSUSA-N	223360	US9315520, 47::US9605007, Example 47::US9744173, Example 47	Isoform D of Beta-secretase 1 (BACE-I-432)			 101					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223360	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223360&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435595	336285235							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390450	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)nc2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-11-6-30-17(21)25-18(11,8-27-9)15-24-12(7-29-15)23-14(26)10-2-3-13(22-5-10)28-16(19)20/h2-3,5,7,9,11,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,11-,18-/m0/s1	FHBJDCALKCDUTG-DNTLEWNLSA-N	223361	US9315520, 48::US9605007, Example 48::US9744173, Example 48	Isoform D of Beta-secretase 1 (BACE-I-432)			 232					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223361	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223361&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435584	336285236							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390451	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2coc(C)n2)cs1	InChI=1S/C16H19N5O3S2/c1-8-3-10-5-26-15(17)21-16(10,7-24-8)14-20-12(6-25-14)19-13(22)11-4-23-9(2)18-11/h4,6,8,10H,3,5,7H2,1-2H3,(H2,17,21)(H,19,22)/t8-,10-,16-/m0/s1	GBRGCYPLTRHZCZ-ACZUWMGVSA-N	223362	US9315520, 49::US9605007, Example 49::US9744173, Example 49	Isoform D of Beta-secretase 1 (BACE-I-432)			 103					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223362	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223362&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435456	336285237							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390452	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2coc(n2)C(F)(F)F)cs1	InChI=1S/C16H16F3N5O3S2/c1-7-2-8-4-29-14(20)24-15(8,6-27-7)13-23-10(5-28-13)22-11(25)9-3-26-12(21-9)16(17,18)19/h3,5,7-8H,2,4,6H2,1H3,(H2,20,24)(H,22,25)/t7-,8-,15-/m0/s1	OFGNUYLKKKCTPY-VQLIFVOLSA-N	223363	US9315520, 50::US9605007, Example 50::US9744173, Example 50	Isoform D of Beta-secretase 1 (BACE-I-432)			 189					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223363	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223363&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435594	336285238							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390453	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nc(C)no2)cs1	InChI=1S/C15H18N6O3S2/c1-7-3-9-4-26-14(16)20-15(9,6-23-7)13-19-10(5-25-13)18-11(22)12-17-8(2)21-24-12/h5,7,9H,3-4,6H2,1-2H3,(H2,16,20)(H,18,22)/t7-,9-,15-/m0/s1	AQIUHWLUHZEXFK-UHCFIKNESA-N	223364	US9315520, 51::US9605007, Example 51::US9744173, Example 51	Isoform D of Beta-secretase 1 (BACE-I-432)			 98					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223364	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223364&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435569	336285239							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390454	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2noc(C)n2)cs1	InChI=1S/C15H18N6O3S2/c1-7-3-9-4-26-14(16)20-15(9,6-23-7)13-19-10(5-25-13)18-12(22)11-17-8(2)24-21-11/h5,7,9H,3-4,6H2,1-2H3,(H2,16,20)(H,18,22)/t7-,9-,15-/m0/s1	YZIWNCOTCWRMSQ-UHCFIKNESA-N	223365	US9315520, 52::US9605007, Example 52::US9744173, Example 52	Isoform D of Beta-secretase 1 (BACE-I-432)			 91					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223365	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223365&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435517	336285240							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390455	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nc(C)oc2C)cs1	InChI=1S/C17H21N5O3S2/c1-8-4-11-5-27-16(18)22-17(11,7-24-8)15-21-12(6-26-15)20-14(23)13-9(2)25-10(3)19-13/h6,8,11H,4-5,7H2,1-3H3,(H2,18,22)(H,20,23)/t8-,11-,17-/m0/s1	AZQXJBAPDQNPHK-UUFZHILXSA-N	223366	US9315520, 53::US9605007, Example 53::US9744173, Example 53	Isoform D of Beta-secretase 1 (BACE-I-432)			 65					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223366	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223366&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435553	336285241							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390456	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(OCC3CC3)cn2)cs1	InChI=1S/C20H24N6O3S2/c1-11-4-13-8-31-19(21)26-20(13,10-29-11)18-25-15(9-30-18)24-17(27)14-5-23-16(6-22-14)28-7-12-2-3-12/h5-6,9,11-13H,2-4,7-8,10H2,1H3,(H2,21,26)(H,24,27)/t11-,13-,20-/m0/s1	NTZLXCBNRLXSKA-LOOLNKMNSA-N	223367	US9315520, 54::US9605007, Example 54::US9744173, Example 54	Isoform D of Beta-secretase 1 (BACE-I-432)			 161					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223367	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223367&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435405	336285242							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390457	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(OC3CC3)cn2)cs1	InChI=1S/C19H22N6O3S2/c1-10-4-11-7-30-18(20)25-19(11,9-27-10)17-24-14(8-29-17)23-16(26)13-5-22-15(6-21-13)28-12-2-3-12/h5-6,8,10-12H,2-4,7,9H2,1H3,(H2,20,25)(H,23,26)/t10-,11-,19-/m0/s1	PXDXKVAQKOIJDD-ADWYPQAOSA-N	223368	US9315520, 55::US9605007, Example 55::US9744173, Example 55	Isoform D of Beta-secretase 1 (BACE-I-432)			 519					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223368	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223368&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435356	336285243							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390458	C[C@@H](F)COc1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C19H23FN6O3S2/c1-10(20)6-28-15-5-22-13(4-23-15)16(27)24-14-8-30-17(25-14)19-9-29-11(2)3-12(19)7-31-18(21)26-19/h4-5,8,10-12H,3,6-7,9H2,1-2H3,(H2,21,26)(H,24,27)/t10-,11+,12+,19+/m1/s1	WFZJVMNFHPJIGJ-FAQIYOQMSA-N	223369	US9315520, 56::US9605007, Example 56::US9744173, Example 56	Isoform D of Beta-secretase 1 (BACE-I-432)			 360					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223369	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223369&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435448	336285244							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390459	C[C@H](F)COc1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C19H23FN6O3S2/c1-10(20)6-28-15-5-22-13(4-23-15)16(27)24-14-8-30-17(25-14)19-9-29-11(2)3-12(19)7-31-18(21)26-19/h4-5,8,10-12H,3,6-7,9H2,1-2H3,(H2,21,26)(H,24,27)/t10-,11-,12-,19-/m0/s1	WFZJVMNFHPJIGJ-DEFUNYHZSA-N	223370	US9315520, 57::US9744173, Example 57	Isoform D of Beta-secretase 1 (BACE-I-432)			 372					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223370	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223370&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435354	336285245							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390460	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2cnc(OCC(C)(F)F)cn2)cs1	InChI=1S/C19H22F2N6O3S2/c1-10-3-11-6-32-17(22)27-19(11,9-29-10)16-26-13(7-31-16)25-15(28)12-4-24-14(5-23-12)30-8-18(2,20)21/h4-5,7,10-11H,3,6,8-9H2,1-2H3,(H2,22,27)(H,25,28)/t10-,11-,19-/m0/s1	HWYDXAVLRPSTHY-ADWYPQAOSA-N	223371	US9315520, 58::US9605007, Example 58::US9744173, Example 58	Isoform D of Beta-secretase 1 (BACE-I-432)			 161					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223371	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223371&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435394	336285246							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390461	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2oc(C)nc2C)cs1	InChI=1S/C17H21N5O3S2/c1-8-4-11-5-27-16(18)22-17(11,7-24-8)15-21-12(6-26-15)20-14(23)13-9(2)19-10(3)25-13/h6,8,11H,4-5,7H2,1-3H3,(H2,18,22)(H,20,23)/t8-,11-,17?/m0/s1	PJMDEFSXAQKKNU-VNYAIOOWSA-N	223416	US9315520, 59	Isoform D of Beta-secretase 1 (BACE-I-432)			 740					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223416&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435387	336285284							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390462	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cn(C)nc2C(F)(F)F)cs1	InChI=1S/C17H19F3N6O2S2/c1-8-3-9-5-30-15(21)24-16(9,7-28-8)14-23-11(6-29-14)22-13(27)10-4-26(2)25-12(10)17(18,19)20/h4,6,8-9H,3,5,7H2,1-2H3,(H2,21,24)(H,22,27)/t8-,9-,16?/m0/s1	WSIXANPYMOOJSE-IJLCECLYSA-N	223417	US9315520, 60	Isoform D of Beta-secretase 1 (BACE-I-432)			 3840					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223417	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223417&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435581	336285285							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390463	CC(C)n1cnc(c1)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C18H24N6O2S2/c1-10(2)24-5-13(20-9-24)15(25)21-14-7-27-16(22-14)18-8-26-11(3)4-12(18)6-28-17(19)23-18/h5,7,9-12H,4,6,8H2,1-3H3,(H2,19,23)(H,21,25)/t11-,12-,18?/m0/s1	FPVCCDXUQZIJKQ-WOWAASLYSA-N	223418	US9315520, 61	Isoform D of Beta-secretase 1 (BACE-I-432)			 1830					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223418	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223418&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435470	336285286							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390464	CC(C)Cc1cc(no1)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C19H25N5O3S2/c1-10(2)4-13-6-14(24-27-13)16(25)21-15-8-28-17(22-15)19-9-26-11(3)5-12(19)7-29-18(20)23-19/h6,8,10-12H,4-5,7,9H2,1-3H3,(H2,20,23)(H,21,25)/t11-,12-,19?/m0/s1	RONGFOZZCCZHJR-MVBRQXBDSA-N	223419	US9315520, 62	Isoform D of Beta-secretase 1 (BACE-I-432)			 9690					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223419	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223419&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435566	336285287							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390465	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cnn(C)c2)cs1	InChI=1S/C16H20N6O2S2/c1-9-3-11-6-26-15(17)21-16(11,8-24-9)14-20-12(7-25-14)19-13(23)10-4-18-22(2)5-10/h4-5,7,9,11H,3,6,8H2,1-2H3,(H2,17,21)(H,19,23)/t9-,11-,16?/m0/s1	FLSYKADZRPHBBY-NEYSTMPUSA-N	223420	US9315520, 63	Isoform D of Beta-secretase 1 (BACE-I-432)			 3940					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223420&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435533	336285288							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390466	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cc(C)on2)cs1	InChI=1S/C16H19N5O3S2/c1-8-3-10-5-26-15(17)20-16(10,7-23-8)14-19-12(6-25-14)18-13(22)11-4-9(2)24-21-11/h4,6,8,10H,3,5,7H2,1-2H3,(H2,17,20)(H,18,22)/t8-,10-,16?/m0/s1	CIQZEKVVKGDGEG-CSDMTXSLSA-N	223421	US9315520, 64	Isoform D of Beta-secretase 1 (BACE-I-432)			 2620					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223421	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223421&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435485	336285289							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390467	CC(C)Cc1cc(nn1C)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C20H28N6O2S2/c1-11(2)5-14-7-15(25-26(14)4)17(27)22-16-9-29-18(23-16)20-10-28-12(3)6-13(20)8-30-19(21)24-20/h7,9,11-13H,5-6,8,10H2,1-4H3,(H2,21,24)(H,22,27)/t12-,13-,20?/m0/s1	KIDCVTNWJYBYFJ-CFLSSUJWSA-N	223422	US9315520, 65	Isoform D of Beta-secretase 1 (BACE-I-432)			 51000					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223422&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435609	336285290							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390468	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccncn2)cs1	InChI=1S/C16H18N6O2S2/c1-9-4-10-5-26-15(17)22-16(10,7-24-9)14-21-12(6-25-14)20-13(23)11-2-3-18-8-19-11/h2-3,6,8-10H,4-5,7H2,1H3,(H2,17,22)(H,20,23)/t9-,10-,16?/m0/s1	PXWFEBPIVDFJNU-VLVWQGGMSA-N	223423	US9315520, 66	Isoform D of Beta-secretase 1 (BACE-I-432)			 575					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223423&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435526	336285291							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390469	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cc(C)no2)cs1	InChI=1S/C16H19N5O3S2/c1-8-3-11(24-21-8)13(22)18-12-6-25-14(19-12)16-7-23-9(2)4-10(16)5-26-15(17)20-16/h3,6,9-10H,4-5,7H2,1-2H3,(H2,17,20)(H,18,22)/t9-,10-,16?/m0/s1	GBCMWKCOVLVKAA-VLVWQGGMSA-N	223424	US9315520, 67	Isoform D of Beta-secretase 1 (BACE-I-432)			 5040					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223424&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435505	336285292							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390470	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cnc(C)cn2)cs1	InChI=1S/C17H20N6O2S2/c1-9-4-20-12(5-19-9)14(24)21-13-7-26-15(22-13)17-8-25-10(2)3-11(17)6-27-16(18)23-17/h4-5,7,10-11H,3,6,8H2,1-2H3,(H2,18,23)(H,21,24)/t10-,11-,17?/m0/s1	RVLGYTRATZMUDO-BFNLLXIESA-N	223425	US9315520, 68	Isoform D of Beta-secretase 1 (BACE-I-432)			 2110					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223425&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435388	336285293							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390471	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cc3CCCn3n2)cs1	InChI=1S/C18H22N6O2S2/c1-10-5-11-7-28-17(19)22-18(11,9-26-10)16-21-14(8-27-16)20-15(25)13-6-12-3-2-4-24(12)23-13/h6,8,10-11H,2-5,7,9H2,1H3,(H2,19,22)(H,20,25)/t10-,11-,18?/m0/s1	HFWGFZWZOIDXSR-QMZNTLOPSA-N	223426	US9315520, 69	Isoform D of Beta-secretase 1 (BACE-I-432)			 6200					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223426&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435608	336285294							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390472	CC(C)c1cc(C(=O)Nc2csc(n2)C23CO[C@@H](C)C[C@H]2CSC(N)=N3)n(C)n1	InChI=1S/C19H26N6O2S2/c1-10(2)13-6-14(25(4)24-13)16(26)21-15-8-28-17(22-15)19-9-27-11(3)5-12(19)7-29-18(20)23-19/h6,8,10-12H,5,7,9H2,1-4H3,(H2,20,23)(H,21,26)/t11-,12-,19?/m0/s1	NLXQVVUOVUDGPI-MVBRQXBDSA-N	223427	US9315520, 70	Isoform D of Beta-secretase 1 (BACE-I-432)			 10400					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223427&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435465	336285295							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390473	CCc1cc(on1)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H21N5O3S2/c1-3-11-5-12(25-22-11)14(23)19-13-7-26-15(20-13)17-8-24-9(2)4-10(17)6-27-16(18)21-17/h5,7,9-10H,3-4,6,8H2,1-2H3,(H2,18,21)(H,19,23)/t9-,10-,17?/m0/s1	FNRRGXMDMGRGGI-IUPUIGEKSA-N	223428	US9315520, 71	Isoform D of Beta-secretase 1 (BACE-I-432)			 9260					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223428&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435539	336285296							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390474	CCn1cc(cn1)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H22N6O2S2/c1-3-23-6-11(5-19-23)14(24)20-13-8-26-15(21-13)17-9-25-10(2)4-12(17)7-27-16(18)22-17/h5-6,8,10,12H,3-4,7,9H2,1-2H3,(H2,18,22)(H,20,24)/t10-,12-,17?/m0/s1	LLDQISFZVVPSKH-LYNBLDOKSA-N	223429	US9315520, 72	Isoform D of Beta-secretase 1 (BACE-I-432)			 7480					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223429&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435615	336285297							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390475	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cc(C)n(C)n2)cs1	InChI=1S/C17H22N6O2S2/c1-9-4-12(22-23(9)3)14(24)19-13-7-26-15(20-13)17-8-25-10(2)5-11(17)6-27-16(18)21-17/h4,7,10-11H,5-6,8H2,1-3H3,(H2,18,21)(H,19,24)/t10-,11-,17?/m0/s1	AVZBGLMNMNRZIT-BFNLLXIESA-N	223430	US9315520, 73	Isoform D of Beta-secretase 1 (BACE-I-432)			 12400					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223430&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435471	336285298							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390476	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ncnn2C)cs1	InChI=1S/C15H19N7O2S2/c1-8-3-9-4-26-14(16)21-15(9,6-24-8)13-20-10(5-25-13)19-12(23)11-17-7-18-22(11)2/h5,7-9H,3-4,6H2,1-2H3,(H2,16,21)(H,19,23)/t8-,9-,15?/m0/s1	RHEXMKAPUVMCJM-KZGJKODISA-N	223431	US9315520, 74	Isoform D of Beta-secretase 1 (BACE-I-432)			 4560					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223431&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435476	336285299							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390477	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cn(C)cn2)cs1	InChI=1S/C16H20N6O2S2/c1-9-3-10-5-26-15(17)21-16(10,7-24-9)14-20-12(6-25-14)19-13(23)11-4-22(2)8-18-11/h4,6,8-10H,3,5,7H2,1-2H3,(H2,17,21)(H,19,23)/t9-,10-,16?/m0/s1	NPGXSCFUAULWBJ-VLVWQGGMSA-N	223432	US9315520, 75	Isoform D of Beta-secretase 1 (BACE-I-432)			 18200					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223432&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435567	336285300							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390478	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cn(C)nn2)cs1	InChI=1S/C15H19N7O2S2/c1-8-3-9-5-26-14(16)19-15(9,7-24-8)13-18-11(6-25-13)17-12(23)10-4-22(2)21-20-10/h4,6,8-9H,3,5,7H2,1-2H3,(H2,16,19)(H,17,23)/t8-,9-,15?/m0/s1	ICLDUMUTESAFQC-KZGJKODISA-N	223433	US9315520, 76	Isoform D of Beta-secretase 1 (BACE-I-432)			 28100					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223433&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435500	336285301							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390479	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccon2)cs1	InChI=1S/C15H17N5O3S2/c1-8-4-9-5-25-14(16)19-15(9,7-22-8)13-18-11(6-24-13)17-12(21)10-2-3-23-20-10/h2-3,6,8-9H,4-5,7H2,1H3,(H2,16,19)(H,17,21)/t8-,9-,15?/m0/s1	OFIOBUSIAWOIEX-KZGJKODISA-N	223434	US9315520, 77	Isoform D of Beta-secretase 1 (BACE-I-432)			 777					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223434&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435598	336285302							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390480	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)C2CC(F)(F)C2)cs1	InChI=1S/C16H20F2N4O2S2/c1-8-2-10-5-26-14(19)22-16(10,7-24-8)13-21-11(6-25-13)20-12(23)9-3-15(17,18)4-9/h6,8-10H,2-5,7H2,1H3,(H2,19,22)(H,20,23)/t8-,10-,16?/m0/s1	LZHZISYSJQHIJA-CSDMTXSLSA-N	223435	US9315520, 78	Isoform D of Beta-secretase 1 (BACE-I-432)			 1490					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223435&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435421	336285303							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390481	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ncccn2)cs1	InChI=1S/C16H18N6O2S2/c1-9-5-10-6-26-15(17)22-16(10,8-24-9)14-21-11(7-25-14)20-13(23)12-18-3-2-4-19-12/h2-4,7,9-10H,5-6,8H2,1H3,(H2,17,22)(H,20,23)/t9-,10-,16?/m0/s1	QYAIWFZNAKNPKY-VLVWQGGMSA-N	223436	US9315520, 79	Isoform D of Beta-secretase 1 (BACE-I-432)			 1080					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223436&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435498	336285304							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390482	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cnn(c2)C2CC2)cs1	InChI=1S/C18H22N6O2S2/c1-10-4-12-7-28-17(19)23-18(12,9-26-10)16-22-14(8-27-16)21-15(25)11-5-20-24(6-11)13-2-3-13/h5-6,8,10,12-13H,2-4,7,9H2,1H3,(H2,19,23)(H,21,25)/t10-,12-,18?/m0/s1	WXZKFRXDHNGWPE-NTMPORJMSA-N	223437	US9315520, 80	Isoform D of Beta-secretase 1 (BACE-I-432)			 8070					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223437	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223437&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435516	336285305							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390483	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cc(Cl)n(C)n2)cs1	InChI=1S/C16H19ClN6O2S2/c1-8-3-9-5-27-15(18)21-16(9,7-25-8)14-20-12(6-26-14)19-13(24)10-4-11(17)23(2)22-10/h4,6,8-9H,3,5,7H2,1-2H3,(H2,18,21)(H,19,24)/t8-,9-,16?/m0/s1	DKLUJYYJLVYPHL-IJLCECLYSA-N	223438	US9315520, 81	Isoform D of Beta-secretase 1 (BACE-I-432)			 3380					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223438&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435568	336285306							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390484	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cnc(cn2)C2CC2)cs1	InChI=1S/C19H22N6O2S2/c1-10-4-12-7-29-18(20)25-19(12,9-27-10)17-24-15(8-28-17)23-16(26)14-6-21-13(5-22-14)11-2-3-11/h5-6,8,10-12H,2-4,7,9H2,1H3,(H2,20,25)(H,23,26)/t10-,12-,19?/m0/s1	RFUMLYLKYQXOPK-OSGQXNIWSA-N	223439	US9315520, 82	Isoform D of Beta-secretase 1 (BACE-I-432)			 1080					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223439	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223439&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435614	336285307							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390485	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2cnn(c2)C(F)F)cs1	InChI=1S/C16H18F2N6O2S2/c1-8-2-10-5-28-15(19)23-16(10,7-26-8)13-22-11(6-27-13)21-12(25)9-3-20-24(4-9)14(17)18/h3-4,6,8,10,14H,2,5,7H2,1H3,(H2,19,23)(H,21,25)/t8-,10-,16?/m0/s1	NWEMGDSSJNZOBN-CSDMTXSLSA-N	223440	US9315520, 83	Isoform D of Beta-secretase 1 (BACE-I-432)			 671					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223440	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223440&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435487	336285308							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390486	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccn(n2)C2CC2)cs1	InChI=1S/C18H22N6O2S2/c1-10-6-11-7-28-17(19)22-18(11,9-26-10)16-21-14(8-27-16)20-15(25)13-4-5-24(23-13)12-2-3-12/h4-5,8,10-12H,2-3,6-7,9H2,1H3,(H2,19,22)(H,20,25)/t10-,11-,18?/m0/s1	HZGLGJXZLAZTTP-QMZNTLOPSA-N	223441	US9315520, 84	Isoform D of Beta-secretase 1 (BACE-I-432)			 1660					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223441	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223441&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435435	336285309							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390487	C[C@H]1C[C@H]2CSC(N)=NC2(CO1)c1nc(NC(=O)c2ccnn2C2CC2)cs1	InChI=1S/C18H22N6O2S2/c1-10-6-11-7-28-17(19)23-18(11,9-26-10)16-22-14(8-27-16)21-15(25)13-4-5-20-24(13)12-2-3-12/h4-5,8,10-12H,2-3,6-7,9H2,1H3,(H2,19,23)(H,21,25)/t10-,11-,18?/m0/s1	LDANGPADBQPDMH-QMZNTLOPSA-N	223442	US9315520, 85	Isoform D of Beta-secretase 1 (BACE-I-432)			 4240					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223442	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223442&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435496	336285310							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390488	CC(C)c1nc(co1)C(=O)Nc1csc(n1)C12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C18H23N5O3S2/c1-9(2)15-20-12(5-25-15)14(24)21-13-7-27-16(22-13)18-8-26-10(3)4-11(18)6-28-17(19)23-18/h5,7,9-11H,4,6,8H2,1-3H3,(H2,19,23)(H,21,24)/t10-,11-,18?/m0/s1	GQLFTOKYLBAWJN-QMZNTLOPSA-N	223443	US9315520, 86	Isoform D of Beta-secretase 1 (BACE-I-432)			 16200					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223443	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223443&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435511	336285311							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390489	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccn(CC(F)F)n2)cs1	InChI=1S/C17H20F2N6O2S2/c1-9-4-10-6-29-16(20)23-17(10,8-27-9)15-22-13(7-28-15)21-14(26)11-2-3-25(24-11)5-12(18)19/h2-3,7,9-10,12H,4-6,8H2,1H3,(H2,20,23)(H,21,26)/t9-,10-,17-/m0/s1	VLPCCGAGIGLCDG-YMNVWFMLSA-N	223372	US9315520, 87::US9605007, Example 87::US9744173, Example 87	Isoform D of Beta-secretase 1 (BACE-I-432)			 398					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223372	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223372&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435578	336285247							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390490	COCCn1ccc(n1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C18H24N6O3S2/c1-11-7-12-8-29-17(19)22-18(12,10-27-11)16-21-14(9-28-16)20-15(25)13-3-4-24(23-13)5-6-26-2/h3-4,9,11-12H,5-8,10H2,1-2H3,(H2,19,22)(H,20,25)/t11-,12-,18-/m0/s1	VXUZLGFPTHMPDO-PZROIBLQSA-N	223373	US9315520, 88::US9605007, Example 88::US9744173, Example 88	Isoform D of Beta-secretase 1 (BACE-I-432)			 418					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223373	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223373&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435400	336285248							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390491	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccn(CC#C)n2)cs1	InChI=1S/C18H20N6O2S2/c1-3-5-24-6-4-13(23-24)15(25)20-14-9-27-16(21-14)18-10-26-11(2)7-12(18)8-28-17(19)22-18/h1,4,6,9,11-12H,5,7-8,10H2,2H3,(H2,19,22)(H,20,25)/t11-,12-,18-/m0/s1	NSZZOQRTNRDMDA-PZROIBLQSA-N	223374	US9315520, 89::US9605007, Example 89::US9744173, Example 92	Isoform D of Beta-secretase 1 (BACE-I-432)			 17					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223374	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223374&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435537	336285249							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390492	COCc1nc(co1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C17H21N5O4S2/c1-9-3-10-6-28-16(18)22-17(10,8-26-9)15-21-12(7-27-15)20-14(23)11-4-25-13(19-11)5-24-2/h4,7,9-10H,3,5-6,8H2,1-2H3,(H2,18,22)(H,20,23)/t9-,10-,17-/m0/s1	ZYIJHQUUGUPTRV-YMNVWFMLSA-N	223375	US9315520, 90::US9605007, Example 90::US9744173, Example 90	Isoform D of Beta-secretase 1 (BACE-I-432)			 175					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223375	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223375&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435426	336285250							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390493	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2coc(CC(F)(F)F)n2)cs1	InChI=1S/C17H18F3N5O3S2/c1-8-2-9-5-30-15(21)25-16(9,7-28-8)14-24-11(6-29-14)23-13(26)10-4-27-12(22-10)3-17(18,19)20/h4,6,8-9H,2-3,5,7H2,1H3,(H2,21,25)(H,23,26)/t8-,9-,16-/m0/s1	MXMJZWBLZHRJJU-BEPCFFQHSA-N	223376	US9315520, 91::US9605007, Example 91::US9744173, Example 91	Isoform D of Beta-secretase 1 (BACE-I-432)			 215					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223376	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223376&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435499	336285251							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390494	CC#CCn1ccc(n1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C19H22N6O2S2/c1-3-4-6-25-7-5-14(24-25)16(26)21-15-10-28-17(22-15)19-11-27-12(2)8-13(19)9-29-18(20)23-19/h5,7,10,12-13H,6,8-9,11H2,1-2H3,(H2,20,23)(H,21,26)/t12-,13-,19-/m0/s1	KCURIJGLRGGXQR-JMERFSKESA-N	223377	US9315520, 92::US9605007, Example 92	Isoform D of Beta-secretase 1 (BACE-I-432)			 82					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223377	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223377&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435623	336285252							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390495	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2CCC2)cs1	InChI=1S/C16H22N4O2S2/c1-9-5-11-6-24-15(17)20-16(11,8-22-9)14-19-12(7-23-14)18-13(21)10-3-2-4-10/h7,9-11H,2-6,8H2,1H3,(H2,17,20)(H,18,21)/t9-,11-,16-/m0/s1	MGOMWLLZKHEFEX-QEKSWQHZSA-N	223378	US9315520, 93::US9605007, Example 93::US9744173, Example 93	Isoform D of Beta-secretase 1 (BACE-I-432)			 376					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223378	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223378&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435545	336285253							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390496	CC#CCOc1ccc(nc1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C21H23N5O3S2/c1-3-4-7-28-15-5-6-16(23-9-15)18(27)24-17-11-30-19(25-17)21-12-29-13(2)8-14(21)10-31-20(22)26-21/h5-6,9,11,13-14H,7-8,10,12H2,1-2H3,(H2,22,26)(H,24,27)/t13-,14-,21-/m0/s1	OPGYDARCLCTRIU-RXSFTSLZSA-N	223379	US9315520, 94::US9605007, Example 94::US9744173, Example 94	Isoform D of Beta-secretase 1 (BACE-I-432)			 18					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223379	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223379&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435625	336285254							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390497	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nc(co2)C(F)F)cs1	InChI=1S/C16H17F2N5O3S2/c1-7-2-8-4-28-15(19)23-16(8,6-26-7)14-22-10(5-27-14)21-12(24)13-20-9(3-25-13)11(17)18/h3,5,7-8,11H,2,4,6H2,1H3,(H2,19,23)(H,21,24)/t7-,8-,16-/m0/s1	AUFMLGTWSVZIJK-UFIJUMAVSA-N	223380	US9315520, 95::US9605007, Example 95::US9744173, Example 95	Isoform D of Beta-secretase 1 (BACE-I-432)			 75					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223380	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223380&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435583	336285255							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390498	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nn(cc2C)C(F)F)cs1	InChI=1S/C17H20F2N6O2S2/c1-8-4-25(15(18)19)24-12(8)13(26)21-11-6-28-14(22-11)17-7-27-9(2)3-10(17)5-29-16(20)23-17/h4,6,9-10,15H,3,5,7H2,1-2H3,(H2,20,23)(H,21,26)/t9-,10-,17-/m0/s1	NZUIPBJGYCNZHU-YMNVWFMLSA-N	223381	US9315520, 96::US9605007, Example 96::US9744173, Example 96	Isoform D of Beta-secretase 1 (BACE-I-432)			 2					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223381	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223381&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			91971333	336285256							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390499	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)cn2)cs1	InChI=1S/C17H18F2N6O3S2/c1-8-2-9-5-30-16(20)25-17(9,7-27-8)14-24-11(6-29-14)23-13(26)12-21-3-10(4-22-12)28-15(18)19/h3-4,6,8-9,15H,2,5,7H2,1H3,(H2,20,25)(H,23,26)/t8-,9-,17-/m0/s1	FIYXMKDQPHXQOF-GSRNSYJJSA-N	223382	US9315520, 97::US9605007, Example 97::US9744173, Example 97	Isoform D of Beta-secretase 1 (BACE-I-432)			 177					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223382	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223382&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435610	336285257							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390500	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)nc2C)cs1	InChI=1S/C18H20F2N6O3S2/c1-8-3-10-5-31-17(21)26-18(10,7-28-8)15-25-11(6-30-15)24-14(27)13-9(2)23-12(4-22-13)29-16(19)20/h4,6,8,10,16H,3,5,7H2,1-2H3,(H2,21,26)(H,24,27)/t8-,10-,18-/m0/s1	WAUMCGCMJMRYCC-HDESESHFSA-N	223383	US9315520, 98::US9605007, Example 98::US9744173, Example 98	Isoform D of Beta-secretase 1 (BACE-I-432)			 33					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223383	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223383&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435374	336285258							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390501	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)cs1	InChI=1S/C18H18ClF2N5O3S2/c1-8-2-9-5-31-17(22)26-18(9,7-28-8)15-25-12(6-30-15)24-14(27)13-11(19)3-10(4-23-13)29-16(20)21/h3-4,6,8-9,16H,2,5,7H2,1H3,(H2,22,26)(H,24,27)/t8-,9-,18-/m0/s1	CJOUKFNXLBLNRB-ZMFHDSSTSA-N	223384	US9315520, 99::US9605007, Example 99::US9744173, Example 99	Isoform D of Beta-secretase 1 (BACE-I-432)			 25					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223384	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223384&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435454	336285259							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390502	COCC(F)(F)c1cnc(cn1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C19H22F2N6O3S2/c1-10-3-11-6-32-17(22)27-18(11,8-30-10)16-26-14(7-31-16)25-15(28)12-4-24-13(5-23-12)19(20,21)9-29-2/h4-5,7,10-11H,3,6,8-9H2,1-2H3,(H2,22,27)(H,25,28)/t10-,11-,18-/m0/s1	AVKVXUHPNSLPBM-FHGNATFXSA-N	223385	US9315520, 100::US9605007, Example 100::US9744173, Example 100	Isoform D of Beta-secretase 1 (BACE-I-432)			 220					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223385	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223385&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435523	336285260							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390503	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC[N+]#[C-])cn2)cs1	InChI=1S/C19H20N6O3S2/c1-11-5-12-7-30-18(20)25-19(12,9-27-11)17-24-15(8-29-17)23-16(26)14-4-3-13(6-22-14)28-10-21-2/h3-4,6,8,11-12H,5,7,9-10H2,1H3,(H2,20,25)(H,23,26)/t11-,12-,19-/m0/s1	YNKQUDNLALCMII-ZKTNFTSUSA-N	223386	US9315520, 101	Isoform D of Beta-secretase 1 (BACE-I-432)			 447					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223386	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223386&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			123737674	336285261							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390504	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2nc(CF)oc2C)cs1	InChI=1S/C17H20FN5O3S2/c1-8-3-10-5-28-16(19)23-17(10,7-25-8)15-21-11(6-27-15)20-14(24)13-9(2)26-12(4-18)22-13/h6,8,10H,3-5,7H2,1-2H3,(H2,19,23)(H,20,24)/t8-,10-,17-/m0/s1	HXXFWDUJJHJVQL-UYDXONCASA-N	223387	US9315520, 102::US9605007, Example 102::US9744173, Example 102	Isoform D of Beta-secretase 1 (BACE-I-432)			 12					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223387	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223387&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435502	336285262							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390505	COCC(F)(F)c1ccc(nc1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C20H23F2N5O3S2/c1-11-5-13-7-32-18(23)27-19(13,9-30-11)17-26-15(8-31-17)25-16(28)14-4-3-12(6-24-14)20(21,22)10-29-2/h3-4,6,8,11,13H,5,7,9-10H2,1-2H3,(H2,23,27)(H,25,28)/t11-,13-,19-/m0/s1	SWZKQMKJEIGPTJ-BLWXERESSA-N	223388	US9315520, 103::US9605007, Example 103::US9744173, Example 103	Isoform D of Beta-secretase 1 (BACE-I-432)			 282					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223388	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223388&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435427	336285263							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390506	CCC(F)(F)Oc1ccc(nc1)C(=O)Nc1csc(n1)[C@]12CO[C@@H](C)C[C@H]1CSC(N)=N2	InChI=1S/C20H23F2N5O3S2/c1-3-20(21,22)30-13-4-5-14(24-7-13)16(28)25-15-9-31-17(26-15)19-10-29-11(2)6-12(19)8-32-18(23)27-19/h4-5,7,9,11-12H,3,6,8,10H2,1-2H3,(H2,23,27)(H,25,28)/t11-,12-,19-/m0/s1	AMSWUGMEUOIFFW-ZKTNFTSUSA-N	223389	US9315520, 104::US9605007, Example 104::US9744173, Example 104	Isoform D of Beta-secretase 1 (BACE-I-432)			 308					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223389	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223389&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435378	336285264							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390507	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C23CC(C2)C3)cs1	InChI=1S/C17H22N4O2S2/c1-9-2-11-6-25-15(18)21-17(11,8-23-9)14-20-12(7-24-14)19-13(22)16-3-10(4-16)5-16/h7,9-11H,2-6,8H2,1H3,(H2,18,21)(H,19,22)/t9-,10?,11-,16?,17-/m0/s1	APBYGJMZUBCXKD-GRKZCLODSA-N	223390	US9315520, 105::US9605007, Example 105::US9744173, Example 105	Isoform D of Beta-secretase 1 (BACE-I-432)			 85					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223390	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223390&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435439	336285265							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390508	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2(CC2)C#N)cs1	InChI=1S/C16H19N5O2S2/c1-9-4-10-5-25-14(18)21-16(10,8-23-9)13-20-11(6-24-13)19-12(22)15(7-17)2-3-15/h6,9-10H,2-5,8H2,1H3,(H2,18,21)(H,19,22)/t9-,10-,16-/m0/s1	FHNHDVVEABSWBD-PUTJDCORSA-N	223391	US9315520, 106::US9605007, Example 106::US9744173, Example 106	Isoform D of Beta-secretase 1 (BACE-I-432)			 348					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223391	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223391&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435474	336285266							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390509	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2CC2)cs1	InChI=1S/C15H20N4O2S2/c1-8-4-10-5-23-14(16)19-15(10,7-21-8)13-18-11(6-22-13)17-12(20)9-2-3-9/h6,8-10H,2-5,7H2,1H3,(H2,16,19)(H,17,20)/t8-,10-,15-/m0/s1	OVLVGYMJKMQIIL-KPCOEVGBSA-N	223392	US9315520, 107::US9605007, Example 107::US9744173, Example 107	Isoform D of Beta-secretase 1 (BACE-I-432)			 475					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223392	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223392&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435602	336285267							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390510	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2(CCC2)[N+]#[C-])cs1	InChI=1S/C17H21N5O2S2/c1-10-6-11-7-26-15(18)22-17(11,9-24-10)14-21-12(8-25-14)20-13(23)16(19-2)4-3-5-16/h8,10-11H,3-7,9H2,1H3,(H2,18,22)(H,20,23)/t10-,11-,17-/m0/s1	GNLIOIAABVJYGX-DINDLPBHSA-N	223393	US9315520, 108	Isoform D of Beta-secretase 1 (BACE-I-432)			 94					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223393	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223393&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			123692660	336285268							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390511	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2(C)CCC2)cs1	InChI=1S/C17H24N4O2S2/c1-10-6-11-7-25-15(18)21-17(11,9-23-10)14-20-12(8-24-14)19-13(22)16(2)4-3-5-16/h8,10-11H,3-7,9H2,1-2H3,(H2,18,21)(H,19,22)/t10-,11-,17-/m0/s1	WJELMSNRYNVXCO-DINDLPBHSA-N	223394	US9315520, 109::US9605007, Example 109::US9744173, Example 109	Isoform D of Beta-secretase 1 (BACE-I-432)			 461					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223394&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435449	336285269							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390512	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1	ZLZUHACSRMOLLV-RAALSFIWSA-N	223395	US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1	Isoform D of Beta-secretase 1 (BACE-I-432)			 41					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223395&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435360	336285270							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390513	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1	ZLZUHACSRMOLLV-RAALSFIWSA-N	223395	US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1	Isoform D of Beta-secretase 1 (BACE-I-432)			 73					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223395&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435360	336285270							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390514	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(Cl)cn2)cs1	InChI=1S/C17H18ClN5O2S2/c1-9-4-10-6-27-16(19)23-17(10,8-25-9)15-22-13(7-26-15)21-14(24)12-3-2-11(18)5-20-12/h2-3,5,7,9-10H,4,6,8H2,1H3,(H2,19,23)(H,21,24)/t9-,10-,17-/m0/s1	UFKMIVRYLMOXNT-YMNVWFMLSA-N	223396	US9315520, 7::US9315520, Example 7::US9605007, Example 7	Isoform D of Beta-secretase 1 (BACE-I-432)			 33					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223396&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435407	336285271							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390515	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ncc(OC(F)F)cc2C)cs1	InChI=1S/C19H21F2N5O3S2/c1-9-3-12(29-17(20)21)5-23-14(9)15(27)24-13-7-30-16(25-13)19-8-28-10(2)4-11(19)6-31-18(22)26-19/h3,5,7,10-11,17H,4,6,8H2,1-2H3,(H2,22,26)(H,24,27)/t10-,11-,19-/m0/s1	CHAGAOAUIITKPC-ADWYPQAOSA-N	223400	US9315520, 45::US9315520, Example 45::US9605007, Example 45::US9744173, Example 45	Isoform D of Beta-secretase 1 (BACE-I-432)			 23					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223400	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223400&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435524	336285273							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390516	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1	InChI=1S/C18H19F2N5O3S2/c1-9-4-10-6-30-17(21)25-18(10,8-27-9)15-24-13(7-29-15)23-14(26)12-3-2-11(5-22-12)28-16(19)20/h2-3,5,7,9-10,16H,4,6,8H2,1H3,(H2,21,25)(H,23,26)/t9-,10-,18-/m0/s1	ZLZUHACSRMOLLV-RAALSFIWSA-N	223395	US9315520, 1::US9315520, Comparator 1::US9315520, Example 1::US9315520, Example 2::US9605007, Example 1	Isoform D of Beta-secretase 1 (BACE-I-432)			>100000					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223395&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118435360	336285270							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390517	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H20F3N5O3S/c1-10-6-11-8-32-19(24)28-20(11,9-30-10)16-13(21)3-5-15(26-16)27-17(29)14-4-2-12(7-25-14)31-18(22)23/h2-5,7,10-11,18H,6,8-9H2,1H3,(H2,24,28)(H,26,27,29)/t10-,11-,20-/m0/s1	NCLSCERPSPVBHT-MKXJDEKUSA-N	223398	US9315520, Comparator 2::US9315520, Comparator 3::US9605007, Comparator 2::US9744173, Comparator 2	Isoform D of Beta-secretase 1 (BACE-I-432)			 43					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223398	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223398&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118441558	336285272							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1						
390518	C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)ccc1F	InChI=1S/C20H20F3N5O3S/c1-10-6-11-8-32-19(24)28-20(11,9-30-10)16-13(21)3-5-15(26-16)27-17(29)14-4-2-12(7-25-14)31-18(22)23/h2-5,7,10-11,18H,6,8-9H2,1H3,(H2,24,28)(H,26,27,29)/t10-,11-,20-/m0/s1	NCLSCERPSPVBHT-MKXJDEKUSA-N	223398	US9315520, Comparator 2::US9315520, Comparator 3::US9605007, Comparator 2::US9744173, Comparator 2	Isoform D of Beta-secretase 1 (BACE-I-432)			 3					4.5	37.00 C	US Patent		10.7270/Q20000Z5		aid1802663	US9315520	Brodney, MA; Beck, EM; Butler, CR; Zhang, L; O'Neill, BT; Barreiro, G; LaChapelle, EA; Rogers, BN	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223398	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8666&target=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=223398&enzyme=Isoform+D+of+Beta-secretase+1+%28BACE-I-432%29&column=ki&startPg=0&Increment=50&submit=Search			118441558	336285272							1	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK	1FKN,1M4H,1SGZ,1TQF,1W50,1W51,1XN2,1XN3,1XS7,1YM2,1YM4,2B8L,2B8V,2F3E,2F3F,2FDP,2G94,2HIZ,2HM1,2IQG,2IRZ,2IS0,2NTR,2OAH,2OF0,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2P4J,2P83,2P8H,2PH6,2PH8,2QK5,2QMD,2QMF,2QMG,2QP8,2QU2,2QU3,2QZK,2QZL,2VA5,2VA6,2VA7,2VKM,2WJO,2ZDZ,2ZE1,2ZHR,2ZHS,2ZHT,2ZHU,2ZHV,2ZJJ,2ZJK,2ZJM,2ZJN,3CIB,3CIC,3CID,3CKP,3CKR,3DM6,3DUY,3DV1,3DV5,3EXO,3FKT,3H0B,3HVG,3HW1,3I25,3IGB,3IN3,3IN4,3IND,3INE,3INF,3INH,3IVH,3IVI,3IXJ,3IXK,3K5C,3K5D,3K5F,3K5G,3KMX,3KMY,3KN0,3KYR,3L38,3L3A,3L58,3L59,3L5B,3L5C,3L5D,3L5E,3L5F,3LHG,3LNK,3LPI,3LPJ,3LPK,3MSJ,3MSK,3MSL,3N4L,3NSH,3OHF,3OHH,3OOZ,3PI5,3QBH,3QI1,3R1G,3R2F,3RSV,3RSX,3RTH,3RTM,3RTN,3RU1,3RVI,3S2O,3S7L,3S7M,3SKF,3SKG,3TPJ,3TPL,3TPP,3TPR,3U6A,3UDH,3UDJ,3UDK,3UDM,3UDN,3UDP,3UDQ,3UDR,3UDY,3UFL,3UQP,3UQR,3UQU,3UQW,3UQX,3VEU,3VF3,3VG1,3VV6,3VV7,3VV8,3WB4,3WB5,4ACU,4ACX,4AZY,4B00,4B05,4B0Q,4B1D,4B1E,4B70,4B72,4B77,4B78,4D83,4D85,4D88,4D89,4D8C,4DH6,4DI2,4DJU,4DJV,4DJW,4DJX,4DJY,4DPF,4DPI,4DUS,4DV9,4DVF,4EWO,4EXG,4FCO,4FGX,4FM7,4FM8,4FRI,4FRJ,4FRK,4FRS,4FS4,4FSE,4FSL,4GID,4GMI,4H1E,4H3F,4H3G,4H3I,4H3J,4HA5,4HZT,4I0D,4I0E,4I0F,4I0G,4I0H,4I0I,4I0J,4I0Z,4I10,4I11,4I12,4I1C,4IVS,4IVT,4JOO,4JP9,4JPC,4JPE,4K8S,4K9H,4KE0,4KE1,4L7G,4L7H,4L7J,4LC7,4LXA,4LXK,4LXM,4N00,4PZW,4PZX,4R5N,4R8Y,4R91,4R92,4R93,4R95,4RCD,4RCE,4RCF,4RRN,4RRO,4RRS,4TRW,4TRY,4TRZ,4WTU,4WY1,4WY6,4X2L,4X7I,4XKX,4XXS,4YBI,4ZPE,4ZPF,4ZPG,4ZSM,4ZSP,4ZSQ,4ZSR,5CLM,5DQC,5ENK,5ENM,5EZX,5EZZ,5F00,5F01,5HD0,5HDU,5HDV,5HDX,5HDZ,5HE4,5HE5,5HE7,5HTZ,5HU0,5HU1,5I3V,5I3W,5I3X,5I3Y,5IE1,5KQF,5KR8,5MBW,5MCQ,5MXD,5QCO,5QCP,5QCQ,5QCR,5QCS,5QCT,5QCU,5QCV,5QCW,5QCX,5QCY,5QCZ,5QD0,5QD1,5QD2,5QD3,5QD4,5QD5,5QD6,5QD7,5QD8,5QD9,5QDA,5QDB,5QDC,5QDD,5T1U,5T1W,5TOL,5UYU,5V0N,5YGX,5YGY,6BFD,6BFE,6BFW,6BFX,6C2I,6DHC,6DMI,6E3Z,6EQM,6FGY,6JSE,6JSF,6JSG,6JSN,6JT3,6JT4,6NV7,6NV9,6NW3,6OD6,6PZ4,6UVP,6UVV,6UVY,6UWP,6UWV,6WNY,7B1E,7B1P,7B1Q,7D2V,7D2X,7D36,7D5A,7DCZ,7F1D,7MYI,7MYR,7MYU,7N66	Beta-secretase 1	BACE1_HUMAN	P56817	A0M8W7 B0YIU9 E9PE65 H7BXJ9 Q9BYB9 Q9BYC0 Q9BYC1 Q9UJT5 Q9ULS1