BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 188588 CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1 InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3 SFKDMBHAUPXODT-UHFFFAOYSA-N 86639 BC11-15::US9173884, BC11-15 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 2.5e+4 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86639&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2409032 136352688 ZINC03293408 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188599 O=c1nc2sc3ccccc3n2c(=O)n1-c1ccccc1 InChI=1S/C15H9N3O2S/c19-13-16-14-18(11-8-4-5-9-12(11)21-14)15(20)17(13)10-6-2-1-3-7-10/h1-9H FCPXRIBIDATENX-UHFFFAOYSA-N 60808 BDBM86640::US9173884, BC11-19 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60808&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2802078 318123000 ZINC02435357 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188610 Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1 InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29) KCNWFXKVXRZIGO-UHFFFAOYSA-N 60812 BDBM86641::US9173884, BC11-28 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60812&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 3257208 318123002 ZINC37867061 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188621 CCCSc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3 YHNDCCKFNWDQGW-UHFFFAOYSA-N 86642 BC11-38::US9173884, BC11-38 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86642&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2052828 136352691 6559 ZINC02459456 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188632 CCCCSc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C16H18N2OS2/c1-2-3-10-21-16-17-13-9-11-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8H,2-3,9-11H2,1H3 RFJZKWIAOIBWJA-UHFFFAOYSA-N 86643 BC11-38-1::US9173884, BC11-38-1 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86643&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2155145 136352692 ZINC02719706 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188643 CCC(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C16H18N2OS2/c1-3-11(2)21-16-17-13-9-10-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8,11H,3,9-10H2,1-2H3 UWXVMIBCJRNBBP-UHFFFAOYSA-N 86644 BC11-38-2::US9173884, BC11-38-2 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 5.12e+4 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86644&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 3403301 136352693 ZINC00213941 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188654 CCCSc1nc2CCSc2c(=O)n1-c1ccc(C)cc1 InChI=1S/C16H18N2OS2/c1-3-9-21-16-17-13-8-10-20-14(13)15(19)18(16)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3 KGBOKJHTYLICFD-UHFFFAOYSA-N 86645 BC11-38-3::US9173884, BC11-38-3 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86645&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2052838 136352694 ZINC02459466 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 188665 CCCSc1nc2CCSc2c(=O)n1-c1ccccc1OC InChI=1S/C16H18N2O2S2/c1-3-9-22-16-17-11-8-10-21-14(11)15(19)18(16)12-6-4-5-7-13(12)20-2/h4-7H,3,8-10H2,1-2H3 MXDVDZKXHJWBLR-UHFFFAOYSA-N 86646 BC11-38-4::US9173884, BC11-38-4 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1.00e+5 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.12.010 10.7270/Q2FB51JK 22284362 aid1799706 Ceyhan, O; Birsoy, K; Hoffman, CS Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86646&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2155273 136352695 ZINC02719834 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339164 CCCSc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3 YHNDCCKFNWDQGW-UHFFFAOYSA-N 86642 BC11-38::US9173884, BC11-38 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86642&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2052828 136352691 6559 ZINC02459456 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339175 Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1 InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29) KCNWFXKVXRZIGO-UHFFFAOYSA-N 60812 BDBM86641::US9173884, BC11-28 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60812&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 3257208 318123002 ZINC37867061 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339186 O=c1nc2sc3ccccc3n2c(=O)n1-c1ccccc1 InChI=1S/C15H9N3O2S/c19-13-16-14-18(11-8-4-5-9-12(11)21-14)15(20)17(13)10-6-2-1-3-7-10/h1-9H FCPXRIBIDATENX-UHFFFAOYSA-N 60808 BDBM86640::US9173884, BC11-19 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60808&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2802078 318123000 ZINC02435357 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339197 CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1 InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3 SFKDMBHAUPXODT-UHFFFAOYSA-N 86639 BC11-15::US9173884, BC11-15 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 25000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86639&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2409032 136352688 ZINC03293408 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339212 CCCCSc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C16H18N2OS2/c1-2-3-10-21-16-17-13-9-11-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8H,2-3,9-11H2,1H3 RFJZKWIAOIBWJA-UHFFFAOYSA-N 86643 BC11-38-1::US9173884, BC11-38-1 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86643&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2155145 136352692 ZINC02719706 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339223 CCC(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1 InChI=1S/C16H18N2OS2/c1-3-11(2)21-16-17-13-9-10-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8,11H,3,9-10H2,1-2H3 UWXVMIBCJRNBBP-UHFFFAOYSA-N 86644 BC11-38-2::US9173884, BC11-38-2 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 51200 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86644&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 3403301 136352693 ZINC00213941 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339234 CCCSc1nc2CCSc2c(=O)n1-c1ccc(C)cc1 InChI=1S/C16H18N2OS2/c1-3-9-21-16-17-13-8-10-20-14(13)15(19)18(16)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3 KGBOKJHTYLICFD-UHFFFAOYSA-N 86645 BC11-38-3::US9173884, BC11-38-3 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86645&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2052838 136352694 ZINC02459466 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 339245 CCCSc1nc2CCSc2c(=O)n1-c1ccccc1OC InChI=1S/C16H18N2O2S2/c1-3-9-22-16-17-11-8-10-21-14(11)15(19)18(16)12-6-4-5-7-13(12)20-2/h4-7H,3,8-10H2,1-2H3 MXDVDZKXHJWBLR-UHFFFAOYSA-N 86646 BC11-38-4::US9173884, BC11-38-4 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 US Patent 10.7270/Q2PK0DZ6 aid1801800 US9173884 Hoffman, CS; Ceyhan, O Boston College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86646&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 2155273 136352695 ZINC02719834 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51223715 COc1ccccc1NC(=O)C1Cc2cc(OC3CCCC3)c(OC)cc2C(=N1)c1ccccc1 InChI=1S/C29H30N2O4/c1-33-25-15-9-8-14-23(25)31-29(32)24-16-20-17-27(35-21-12-6-7-13-21)26(34-2)18-22(20)28(30-24)19-10-4-3-5-11-19/h3-5,8-11,14-15,17-18,21,24H,6-7,12-13,16H2,1-2H3,(H,31,32) UIIDPEAWDOFXDG-UHFFFAOYSA-N 50502852 CHEMBL4464755 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >200000 ChEMBL 10.1016/j.bmcl.2019.126720 10.7270/Q25X2D6W 31610942 Liao, Y; Jia, X; Tang, Y; Li, S; Zang, Y; Wang, L; Cui, ZN; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502852&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 155530589 440711437 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50303893 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N 14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 24 ChEMBL 10.1016/j.bmc.2015.03.005 10.7270/Q28917JN 25801159 Sawant, SD; Lakshma Reddy, G; Dar, MI; Srinivas, M; Gupta, G; Sahu, PK; Mahajan, P; Nargotra, A; Singh, S; Sharma, SC; Tikoo, M; Singh, G; Vishwakarma, RA; Syed, SH CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search VIA 5212 46514731 9139 CHEMBL192 4743 C07259 ZINC19796168 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50303898 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)NCCCCCCO InChI=1S/C23H33N5O5S/c1-4-10-18-20-21(28(3)27-18)23(30)26-22(25-20)17-15-16(11-12-19(17)33-5-2)34(31,32)24-13-8-6-7-9-14-29/h11-12,15,24,29H,4-10,13-14H2,1-3H3,(H,25,26,30) NWAWSQQMTQQBGL-UHFFFAOYSA-N 50067186 CHEMBL3401745 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 5.2 ChEMBL 10.1016/j.bmc.2015.03.005 10.7270/Q28917JN 25801159 Sawant, SD; Lakshma Reddy, G; Dar, MI; Srinivas, M; Gupta, G; Sahu, PK; Mahajan, P; Nargotra, A; Singh, S; Sharma, SC; Tikoo, M; Singh, G; Vishwakarma, RA; Syed, SH CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067186&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 118728649 103961684 CHEMBL3401745 ZINC13781399 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50432876 COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1 InChI=1S/C21H23F2NO4/c1-26-16-9-6-14(7-10-16)13-24-20(25)15-8-11-18(28-21(22)23)19(12-15)27-17-4-2-3-5-17/h6-12,17,21H,2-5,13H2,1H3,(H,24,25) DBNDIIUELFNMBG-UHFFFAOYSA-N 50129817 CHEMBL3628685 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.bmc.2015.10.033 10.7270/Q2GQ70KG 26526739 Zhou, ZZ; Ge, BC; Chen, YF; Shi, XD; Yang, XM; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129817&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 122193679 321902957 CHEMBL3628685 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50874282 COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(OCCO)cc(O)c2c(=O)c1OCCO InChI=1S/C25H28O8/c1-15(2)4-9-18-20(31-12-10-26)14-19(28)21-22(29)25(32-13-11-27)23(33-24(18)21)16-5-7-17(30-3)8-6-16/h4-8,14,26-28H,9-13H2,1-3H3 WTJGVHRGWYENBZ-UHFFFAOYSA-N 50272529 3,7-Bis(2-hydroxyethyl)icaritin::CHEMBL498486 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 30900 ChEMBL 10.1021/np800049y 10.7270/Q2R78G4G 18778098 Dell'Agli, M; Galli, GV; Dal Cero, E; Belluti, F; Matera, R; Zironi, E; Pagliuca, G; Bosisio, E University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50272529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50272529&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 25058047 104116918 CHEMBL498486 ZINC40976043 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50874283 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N 14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 160 ChEMBL 10.1021/np800049y 10.7270/Q2R78G4G 18778098 Dell'Agli, M; Galli, GV; Dal Cero, E; Belluti, F; Matera, R; Zironi, E; Pagliuca, G; Bosisio, E University of Milan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search VIA 5212 46514731 9139 CHEMBL192 4743 C07259 ZINC19796168 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50975393 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N 14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 39 ChEMBL 10.1021/jm301159y 10.7270/Q2154J6G 23137303 Wang, G; Liu, Z; Chen, T; Wang, Z; Yang, H; Zheng, M; Ren, J; Tian, G; Yang, X; Li, L; Li, J; Suo, J; Zhang, R; Jiang, X; Terrett, NK; Shen, J; Xu, Y; Jiang, H Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search VIA 5212 46514731 9139 CHEMBL192 4743 C07259 ZINC19796168 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50975422 CCCOc1ccc(cc1-c1nc(CC)c(CC)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H32N4O4S/c1-5-14-30-20-9-8-16(31(28,29)26-12-10-25(4)11-13-26)15-18(20)21-23-19(7-3)17(6-2)22(27)24-21/h8-9,15H,5-7,10-14H2,1-4H3,(H,23,24,27) FJJLJIBQQGUEHI-UHFFFAOYSA-N 50399909 CHEMBL2180945 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 46 ChEMBL 10.1021/jm301159y 10.7270/Q2154J6G 23137303 Wang, G; Liu, Z; Chen, T; Wang, Z; Yang, H; Zheng, M; Ren, J; Tian, G; Yang, X; Li, L; Li, J; Suo, J; Zhang, R; Jiang, X; Terrett, NK; Shen, J; Xu, Y; Jiang, H Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399909&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search NI0 46836255 163348933 CHEMBL2180945 ZINC95577125 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50522372 CCOc1ccc(CC2CC(C2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 InChI=1S/C22H27N5O4/c1-4-16-18-19(27(3)25-16)22(29)24-20(23-18)15-11-12(6-7-17(15)31-5-2)8-13-9-14(10-13)21(28)26-30/h6-7,11,13-14,30H,4-5,8-10H2,1-3H3,(H,26,28)(H,23,24,29) WFSWUBOROARLDR-UHFFFAOYSA-N 50196675 CHEMBL3900593 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 2.6 ChEMBL 10.1021/acs.jmedchem.6b00908 10.7270/Q2KP8448 27606546 Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J University of Navarra http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196675&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134133374 375977525 CHEMBL3900593 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50522513 CCOc1ccc(OC2CCN(CC2)c2ncc(cn2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 InChI=1S/C26H30N8O5/c1-4-19-21-22(33(3)31-19)25(36)30-23(29-21)18-12-17(6-7-20(18)38-5-2)39-16-8-10-34(11-9-16)26-27-13-15(14-28-26)24(35)32-37/h6-7,12-14,16,37H,4-5,8-11H2,1-3H3,(H,32,35)(H,29,30,36) GDXUQGMYOAPPJF-UHFFFAOYSA-N 50196772 CHEMBL3936651 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0.130000 ChEMBL 10.1021/acs.jmedchem.6b00908 10.7270/Q2KP8448 27606546 Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J University of Navarra http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196772&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134149668 375977543 CHEMBL3936651 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50543895 FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Cl InChI=1S/C19H18ClF2NO3/c20-14-7-3-4-8-15(14)23-18(24)12-9-10-16(26-19(21)22)17(11-12)25-13-5-1-2-6-13/h3-4,7-11,13,19H,1-2,5-6H2,(H,23,24) IOCQLERZNMLYQW-UHFFFAOYSA-N 50208310 CHEMBL3883753 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208310&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134129996 375982003 CHEMBL3883753 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50543897 FC(F)Oc1ccc(cc1OC1CCCC1)C(=O)Nc1cccnc1 InChI=1S/C18H18F2N2O3/c19-18(20)25-15-8-7-12(10-16(15)24-14-5-1-2-6-14)17(23)22-13-4-3-9-21-11-13/h3-4,7-11,14,18H,1-2,5-6H2,(H,22,23) BPBJURKFWJXNTD-UHFFFAOYSA-N 50208311 CHEMBL3885161 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208311&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134130328 375982004 CHEMBL3885161 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50544278 FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1ccccc1Cl InChI=1S/C18H16ClF2NO3/c19-13-3-1-2-4-14(13)22-17(23)12-7-8-15(25-18(20)21)16(9-12)24-10-11-5-6-11/h1-4,7-9,11,18H,5-6,10H2,(H,22,23) FXJNCIZGQFVQLF-UHFFFAOYSA-N 50208314 CHEMBL3884788 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208314&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134131162 375982005 CHEMBL3884788 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50544297 FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1cccnc1 InChI=1S/C17H16F2N2O3/c18-17(19)24-14-6-5-12(8-15(14)23-10-11-3-4-11)16(22)21-13-2-1-7-20-9-13/h1-2,5-9,11,17H,3-4,10H2,(H,21,22) UZHICMGVAYPCLG-UHFFFAOYSA-N 50208315 CHEMBL3884224 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.ejmech.2016.08.052 10.7270/Q29P33N6 27597413 Zhou, ZZ; Ge, BC; Zhong, QP; Huang, C; Cheng, YF; Yang, XM; Wang, HT; Xu, JP Southern Medical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208315&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 134130563 375982006 CHEMBL3884224 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50741734 COc1ccc(Cn2c3sc4CN(CC5CCOCC5)CCc4c3c3ncnn3c2=O)c(F)c1 InChI=1S/C24H26FN5O3S/c1-32-17-3-2-16(19(25)10-17)12-29-23-21(22-26-14-27-30(22)24(29)31)18-4-7-28(13-20(18)34-23)11-15-5-8-33-9-6-15/h2-3,10,14-15H,4-9,11-13H2,1H3 FOZFBBKUKXGMND-UHFFFAOYSA-N 289653 6-(2-Fluoro-4-methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)methyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5 (6H)-one::US10092575, Example 141::US10376514, Example 141 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.7b00302 10.7270/Q2D79DP3 28406621 Dyck, B; Branstetter, B; Gharbaoui, T; Hudson, AR; Breitenbucher, JG; Gomez, L; Botrous, I; Marrone, T; Barido, R; Allerston, CK; Cedervall, EP; Xu, R; Sridhar, V; Barker, R; Aertgeerts, K; Schmelzer, K; Neul, D; Lee, D; Massari, ME; Andersen, CB; Sebring, K; Zhou, X; Petroski, R; Limberis, J; Augustin, M; Chun, LE; Edwards, TE; Peters, M; Tabatabaei, A Dart Neuroscience LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=289653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=289653&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 72706254 381610018 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50741760 Clc1ccc(Cn2c3sc4CCCCc4c3c3ncnn3c2=O)cc1 InChI=1S/C18H15ClN4OS/c19-12-7-5-11(6-8-12)9-22-17-15(13-3-1-2-4-14(13)25-17)16-20-10-21-23(16)18(22)24/h5-8,10H,1-4,9H2 SRUIZVZXCPBTGE-UHFFFAOYSA-N 292797 US10105367, Example 82::US10376514, Example 82 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 460 ChEMBL 10.1021/acs.jmedchem.7b00302 10.7270/Q2D79DP3 28406621 Dyck, B; Branstetter, B; Gharbaoui, T; Hudson, AR; Breitenbucher, JG; Gomez, L; Botrous, I; Marrone, T; Barido, R; Allerston, CK; Cedervall, EP; Xu, R; Sridhar, V; Barker, R; Aertgeerts, K; Schmelzer, K; Neul, D; Lee, D; Massari, ME; Andersen, CB; Sebring, K; Zhou, X; Petroski, R; Limberis, J; Augustin, M; Chun, LE; Edwards, TE; Peters, M; Tabatabaei, A Dart Neuroscience LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=292797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=292797&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 8HP 137528755 381613084 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50729139 Cc1cc([C@@H]2CN(CC(F)(F)C2)C(=O)c2ccc(F)c(Br)c2)n2ncnc2n1 InChI=1S/C18H15BrF3N5O/c1-10-4-15(27-17(25-10)23-9-24-27)12-6-18(21,22)8-26(7-12)16(28)11-2-3-14(20)13(19)5-11/h2-5,9,12H,6-8H2,1H3/t12-/m0/s1 TTWAYHJJEHLVNR-LBPRGKRZSA-N 50236225 CHEMBL4074744::US11186582, Example 269::US11419874, DNS-8254 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.6b01793 10.7270/Q2Q242GF 28165743 Gomez, L; Massari, ME; Vickers, T; Freestone, G; Vernier, W; Ly, K; Xu, R; McCarrick, M; Marrone, T; Metz, M; Yan, YG; Yoder, ZW; Lemus, R; Broadbent, NJ; Barido, R; Warren, N; Schmelzer, K; Neul, D; Lee, D; Andersen, CB; Sebring, K; Aertgeerts, K; Zhou, X; Tabatabaei, A; Peters, M; Breitenbucher, JG Dart Neuroscience LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236225&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 7OJ 118479645 384991879 CHEMBL4074744 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50759897 COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl InChI=1S/C23H21ClN4O2/c1-14(29)28-8-7-21-18(13-28)23(17-9-15(11-25)3-5-20(17)27-21)26-12-16-4-6-22(30-2)19(24)10-16/h3-6,9-10H,7-8,12-13H2,1-2H3,(H,26,27) YLBRHUHHQIYMSH-UHFFFAOYSA-N 50241831 CHEMBL4062273::US10899756, Compound U Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 30 ChEMBL 10.1021/acs.jmedchem.7b00979 10.7270/Q2J67K3P 28985058 Fiorito, J; Vendome, J; Saeed, F; Staniszewski, A; Zhang, H; Yan, S; Deng, SX; Arancio, O; Landry, DW Columbia University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241831&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 89706867 386402126 CHEMBL4062273 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 50760788 CCN1Cc2nc3ccc(cc3c(NCc3ccc(OC)c(Cl)c3)c2C1=O)C#N InChI=1S/C22H19ClN4O2/c1-3-27-12-18-20(22(27)28)21(15-8-13(10-24)4-6-17(15)26-18)25-11-14-5-7-19(29-2)16(23)9-14/h4-9H,3,11-12H2,1-2H3,(H,25,26) CXMJWJJNVWXSJV-UHFFFAOYSA-N 50241840 CHEMBL4072903::US10899756, Compound K Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 6.6 ChEMBL 10.1021/acs.jmedchem.7b00979 10.7270/Q2J67K3P 28985058 Fiorito, J; Vendome, J; Saeed, F; Staniszewski, A; Zhang, H; Yan, S; Deng, SX; Arancio, O; Landry, DW Columbia University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241840&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 117824250 386402134 CHEMBL4072903 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51119818 COCCNc1cc(O)c2c(c1)oc1c(Cc3ccc4OCOc4c3)[nH]c(-c3nccs3)c1c2=O InChI=1S/C25H21N3O6S/c1-31-6-4-26-14-10-16(29)20-19(11-14)34-24-15(8-13-2-3-17-18(9-13)33-12-32-17)28-22(21(24)23(20)30)25-27-5-7-35-25/h2-3,5,7,9-11,26,28-29H,4,6,8,12H2,1H3 VNWKVRSLWCIUCC-UHFFFAOYSA-N 50459162 CHEMBL4218772 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1.2 ChEMBL 10.1021/acs.jmedchem.8b01209 10.7270/Q26D5WMB 30148362 Wu, D; Huang, Y; Chen, Y; Huang, YY; Geng, H; Zhang, T; Zhang, C; Li, Z; Guo, L; Chen, J; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50459162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50459162&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 138319693 433926427 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51059994 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(Cc2ccc(s2)C(=O)NO)ccc1OCC InChI=1S/C23H25N5O4S/c1-4-6-16-19-20(28(3)26-16)23(30)25-21(24-19)15-12-13(7-9-17(15)32-5-2)11-14-8-10-18(33-14)22(29)27-31/h7-10,12,31H,4-6,11H2,1-3H3,(H,27,29)(H,24,25,30) NGFDENLSEDFSFN-UHFFFAOYSA-N 50458479 CHEMBL4212186 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1.4 ChEMBL 10.1016/j.ejmech.2018.03.005 10.7270/Q2H134MG 29549837 Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J University of Navarra http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458479&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 136645466 433925744 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51114611 COC(=O)C1Cc2cc(OC)c(OC3CCCC3)cc2CN1C(=O)c1ccc(OC(F)(F)F)cc1 InChI=1S/C25H26F3NO6/c1-32-21-12-16-11-20(24(31)33-2)29(14-17(16)13-22(21)34-18-5-3-4-6-18)23(30)15-7-9-19(10-8-15)35-25(26,27)28/h7-10,12-13,18,20H,3-6,11,14H2,1-2H3 WTHDBTGFIKDFRU-UHFFFAOYSA-N 50455383 CHEMBL4215772 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.bmcl.2018.02.056 10.7270/Q2W66PBS 29545101 Liao, Y; Guo, Y; Li, S; Wang, L; Tang, Y; Li, T; Chen, W; Zhong, G; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455383&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 145974174 433923499 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51114625 COc1cc2CCN(Cc2cc1OC1CCCC1)S(=O)(=O)c1ccc(NC(C)=O)cc1 InChI=1S/C23H28N2O5S/c1-16(26)24-19-7-9-21(10-8-19)31(27,28)25-12-11-17-13-22(29-2)23(14-18(17)15-25)30-20-5-3-4-6-20/h7-10,13-14,20H,3-6,11-12,15H2,1-2H3,(H,24,26) MATVLUWHSFXXRL-UHFFFAOYSA-N 50455384 CHEMBL4206423 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.bmcl.2018.02.056 10.7270/Q2W66PBS 29545101 Liao, Y; Guo, Y; Li, S; Wang, L; Tang, Y; Li, T; Chen, W; Zhong, G; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455384&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 145978345 433923500 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51049433 CCc1ccc(s1)C1N(Cc2c1[nH]c1ccccc1c2=O)c1ncccn1 InChI=1S/C21H18N4OS/c1-2-13-8-9-17(27-13)19-18-15(12-25(19)21-22-10-5-11-23-21)20(26)14-6-3-4-7-16(14)24-18/h3-11,19H,2,12H2,1H3,(H,24,26) DRWIDCWXXLOIMG-UHFFFAOYSA-N 50458306 CHEMBL4218398 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 3.7 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458306&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492998 433925571 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51050768 CCc1ccc(s1)C1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5OS/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32) IFMLEMDUMAPODC-UHFFFAOYSA-N 50458312 CHEMBL4209716 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 4.8 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458312&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492968 433925577 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51051084 CCc1ccc(o1)C1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5O2/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32) RNHNQORGLGCJLQ-UHFFFAOYSA-N 50458305 CHEMBL4212630 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 2.3 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458305&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492943 433925570 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51051086 CCc1ccc(s1)[C@@H]1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5OS/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32)/t24-/m0/s1 IFMLEMDUMAPODC-DEOSSOPVSA-N 50458304 CHEMBL4205338 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 34 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458304&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492970 433925569 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51051088 CCc1ccc(s1)[C@H]1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5OS/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32)/t24-/m1/s1 IFMLEMDUMAPODC-XMMPIXPASA-N 50458313 CHEMBL4217054 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1.2 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458313&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492937 433925578 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51051976 CCc1ccc(o1)C1N(Cc2c1[nH]c1ccccc1c2=O)c1ncccn1 InChI=1S/C21H18N4O2/c1-2-13-8-9-17(27-13)19-18-15(12-25(19)21-22-10-5-11-23-21)20(26)14-6-3-4-7-16(14)24-18/h3-11,19H,2,12H2,1H3,(H,24,26) QQMRBUUPHPWYOK-UHFFFAOYSA-N 50458316 CHEMBL4204725 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 6.2 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458316&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141493002 433925581 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51051979 CCc1ccc(o1)[C@H]1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5O2/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32)/t24-/m1/s1 RNHNQORGLGCJLQ-XMMPIXPASA-N 50458314 CHEMBL4217579 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 1.5 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458314&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141492999 433925579 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51052977 CCc1ccc(o1)[C@@H]1N(Cc2c1[nH]c1ccccc1c2=O)c1ncc(cn1)-c1ccccn1 InChI=1S/C26H21N5O2/c1-2-17-10-11-22(33-17)24-23-19(25(32)18-7-3-4-9-21(18)30-23)15-31(24)26-28-13-16(14-29-26)20-8-5-6-12-27-20/h3-14,24H,2,15H2,1H3,(H,30,32)/t24-/m0/s1 RNHNQORGLGCJLQ-DEOSSOPVSA-N 50458318 CHEMBL4208249 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 3.8 ChEMBL 10.1016/j.ejmech.2018.02.039 10.7270/Q2222XCS 29505934 Zheng, H; Li, L; Sun, B; Gao, Y; Song, W; Zhao, X; Gao, Y; Xie, Z; Zhang, N; Ji, J; Yuan, H; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458318&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141493000 433925583 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140578 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m1/s1 VKKJMPZSQBNIOL-APWZRJJASA-N 50467475 CHEMBL4284224 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 10.0 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467475&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737703 433934740 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140611 CCc1ccc(o1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O3/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m1/s1 QTWIOCLYEVHSLI-OXQOHEQNSA-N 50467484 CHEMBL4281590 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467484&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737676 433934749 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140612 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C21H21N3O2S/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m0/s1 PYRZRKTWNHDCON-QFBILLFUSA-N 50467477 CHEMBL4277243 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 56 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467477&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737690 433934742 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140613 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C21H21N3O2S/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19-/m1/s1 PYRZRKTWNHDCON-VQIMIIECSA-N 50467479 CHEMBL4281081 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467479&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737657 433934744 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140633 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(C)o1 InChI=1S/C20H19N3O3/c1-3-22-19(24)15-10-13-12-6-4-5-7-14(12)21-17(13)18(23(15)20(22)25)16-9-8-11(2)26-16/h4-9,15,18,21H,3,10H2,1-2H3/t15-,18+/m0/s1 QFMUYNLRTWIZJM-MAUKXSAKSA-N 50467473 CHEMBL4292389 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 62 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467473&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737704 433934738 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140634 CCc1ccc(s1)[C@@H]1N2[C@@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O2S/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m0/s1 WNVDDMMDUVNDAO-JXFKEZNVSA-N 50467485 CHEMBL4283473 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467485&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737655 433934750 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140635 CCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19-/m1/s1 VKKJMPZSQBNIOL-VQIMIIECSA-N 50467491 CHEMBL4289291 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467491&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737668 433934756 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140644 CCc1ccc(s1)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(C)CC2=O InChI=1S/C21H21N3O2S/c1-3-12-8-9-17(27-12)20-19-14(13-6-4-5-7-15(13)22-19)10-16-21(26)23(2)11-18(25)24(16)20/h4-9,16,20,22H,3,10-11H2,1-2H3/t16-,20-/m1/s1 WNVDDMMDUVNDAO-OXQOHEQNSA-N 50467488 CHEMBL4286052 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467488&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737696 433934753 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140679 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(Br)s2)C1=O InChI=1S/C19H16BrN3O2S/c1-22-9-16(24)23-13(19(22)25)8-11-10-4-2-3-5-12(10)21-17(11)18(23)14-6-7-15(20)26-14/h2-7,13,18,21H,8-9H2,1H3/t13-,18-/m1/s1 KUYGOKWGSHFXJD-FZKQIMNGSA-N 50467474 CHEMBL4289471 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 136 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467474&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 9802738 433934739 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140680 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc(C)s2)C1=O InChI=1S/C20H19N3O2S/c1-11-7-8-16(26-11)19-18-13(12-5-3-4-6-14(12)21-18)9-15-20(25)22(2)10-17(24)23(15)19/h3-8,15,19,21H,9-10H2,1-2H3/t15-,19-/m1/s1 LFVBPBWMEWDRAV-DNVCBOLYSA-N 50467490 CHEMBL4278136 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467490&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737681 433934755 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140681 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)o1 InChI=1S/C21H21N3O3/c1-3-12-9-10-17(27-12)19-18-14(13-7-5-6-8-15(13)22-18)11-16-20(25)23(4-2)21(26)24(16)19/h5-10,16,19,22H,3-4,11H2,1-2H3/t16-,19+/m0/s1 VKKJMPZSQBNIOL-QFBILLFUSA-N 50467472 CHEMBL4281766 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 127 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467472&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737705 433934737 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140682 CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1sccc1C InChI=1S/C20H19N3O2S/c1-3-22-19(24)15-10-13-12-6-4-5-7-14(12)21-16(13)17(23(15)20(22)25)18-11(2)8-9-26-18/h4-9,15,17,21H,3,10H2,1-2H3/t15-,17-/m0/s1 ZJCXRZRYBPCBNM-RDJZCZTQSA-N 50467486 CHEMBL4285199 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 13 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467486&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737666 433934751 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140683 CCCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C23H25N3O2S/c1-3-5-12-25-22(27)18-13-16-15-8-6-7-9-17(15)24-20(16)21(26(18)23(25)28)19-11-10-14(4-2)29-19/h6-11,18,21,24H,3-5,12-13H2,1-2H3/t18-,21+/m0/s1 MHKSTLAWFJQTLC-GHTZIAJQSA-N 50467476 CHEMBL4280648 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 107 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467476&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737667 433934741 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140684 CCCCN1C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c1ccc(CC)s1 InChI=1S/C23H25N3O2S/c1-3-5-12-25-22(27)18-13-16-15-8-6-7-9-17(15)24-20(16)21(26(18)23(25)28)19-11-10-14(4-2)29-19/h6-11,18,21,24H,3-5,12-13H2,1-2H3/t18-,21-/m1/s1 MHKSTLAWFJQTLC-WIYYLYMNSA-N 50467487 CHEMBL4291228 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >1000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467487&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737674 433934752 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140685 CCc1ccc(o1)C1N(CC(=O)c2c1[nH]c1ccccc21)c1ncc(cn1)-c1ccc(OC)c(OC)c1 InChI=1S/C29H26N4O4/c1-4-19-10-12-24(37-19)28-27-26(20-7-5-6-8-21(20)32-27)22(34)16-33(28)29-30-14-18(15-31-29)17-9-11-23(35-2)25(13-17)36-3/h5-15,28,32H,4,16H2,1-3H3 MXRCTQYKTXQWTH-UHFFFAOYSA-N 50467489 CHEMBL4292970 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 288 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467489&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737698 433934754 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140686 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 14777 (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione::(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL779::Cialis::GF 196960::Tadalafil Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14777&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search CIA 110635 46515102 71940 CHEMBL779 DB00820 7299 ZINC03993855 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51140739 CCc1ccc(s1)C1N(CC(=O)c2c1[nH]c1ccccc21)c1ncc(cn1)-c1ccc(OC)c(OC)c1 InChI=1S/C29H26N4O3S/c1-4-19-10-12-25(37-19)28-27-26(20-7-5-6-8-21(20)32-27)22(34)16-33(28)29-30-14-18(15-31-29)17-9-11-23(35-2)24(13-17)36-3/h5-15,28,32H,4,16H2,1-3H3 WKEBNSYJGBPIKM-UHFFFAOYSA-N 50467478 CHEMBL4287438 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 253 ChEMBL 10.1016/j.ejmech.2018.09.028 10.7270/Q2JS9T4N 30245400 Zheng, H; Wu, Y; Sun, B; Cheng, C; Qiao, Y; Jiang, Y; Zhao, S; Xie, Z; Tan, J; Lou, H Shandong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467478&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 141737649 433934743 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51255248 O=C1CN(CCC2CCN(Cc3ccccc3)CC2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1 InChI=1S/C35H36N4O4/c40-32-21-38(17-14-23-12-15-37(16-13-23)20-24-6-2-1-3-7-24)35(41)29-19-27-26-8-4-5-9-28(26)36-33(27)34(39(29)32)25-10-11-30-31(18-25)43-22-42-30/h1-11,18,23,29,34,36H,12-17,19-22H2/t29-,34-/m1/s1 KVANOXIAOYTXBY-ANHUGMMASA-N 50513220 CHEMBL4435044 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >100000 ChEMBL 10.1016/j.ejmech.2019.05.020 10.7270/Q2KH0RNP 31103902 Zhang, P; Xu, S; Zhu, Z; Xu, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513220&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 148279038 440721802 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51256939 Cc1ccc2n(c(CCN3C(=O)c4cccc5cccc(C3=O)c45)nc2c1)-c1ccncc1 InChI=1S/C27H20N4O2/c1-17-8-9-23-22(16-17)29-24(31(23)19-10-13-28-14-11-19)12-15-30-26(32)20-6-2-4-18-5-3-7-21(25(18)20)27(30)33/h2-11,13-14,16H,12,15H2,1H3 VFDVYUMIEWOVJX-UHFFFAOYSA-N 50513788 CHEMBL4558162 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >20000 ChEMBL 10.1021/acs.jmedchem.9b00224 10.7270/Q22B92CV 30888810 Huang, YY; Yu, YF; Zhang, C; Chen, Y; Zhou, Q; Li, Z; Zhou, S; Li, Z; Guo, L; Wu, D; Wu, Y; Luo, HB Sun Yat-sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513788&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search AEL 137700779 440722370 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51223663 COc1cc2C(=NC(Cc2cc1OC1CCCC1)C(=O)Nc1ccccc1OC(F)(F)F)c1ccccc1 InChI=1S/C29H27F3N2O4/c1-36-25-17-21-19(16-26(25)37-20-11-5-6-12-20)15-23(33-27(21)18-9-3-2-4-10-18)28(35)34-22-13-7-8-14-24(22)38-29(30,31)32/h2-4,7-10,13-14,16-17,20,23H,5-6,11-12,15H2,1H3,(H,34,35) KZKPKVMAYKNNDQ-UHFFFAOYSA-N 50502858 CHEMBL4451855 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >200000 ChEMBL 10.1016/j.bmcl.2019.126720 10.7270/Q25X2D6W 31610942 Liao, Y; Jia, X; Tang, Y; Li, S; Zang, Y; Wang, L; Cui, ZN; Song, G South China Agricultural University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502858&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 155521936 440711443 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51288142 COc1cc2CCN(C=O)[C@@H](CCc3c[nH]c4cc(C)ccc34)c2cc1OC InChI=1S/C23H26N2O3/c1-15-4-6-18-17(13-24-20(18)10-15)5-7-21-19-12-23(28-3)22(27-2)11-16(19)8-9-25(21)14-26/h4,6,10-14,21,24H,5,7-9H2,1-3H3/t21-/m0/s1 OIDQRHGTWLIKKZ-NRFANRHFSA-N 50525165 CHEMBL4527894 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 3300 ChEMBL 10.1021/acs.jmedchem.9b00518 10.7270/Q2S75KRZ 31099559 Zhang, X; Dong, G; Li, H; Chen, W; Li, J; Feng, C; Gu, Z; Zhu, F; Zhang, R; Li, M; Tang, W; Liu, H; Xu, Y Shanghai Institute of Materia Medica http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525165&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search AKO 138393292 440733747 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51287591 CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 14777 (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione::(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL779::Cialis::GF 196960::Tadalafil Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 402 ChEMBL 10.1021/acs.jmedchem.9b00123 10.7270/Q2T72MWB 31021628 Wang, Z; Jiang, X; Zhang, X; Tian, G; Yang, R; Wu, J; Zou, X; Liu, Z; Yang, X; Wu, C; Shi, J; Li, J; Suo, J; Wang, Y; Zhang, R; Xu, Z; Gong, X; He, Y; Zhu, W; Aisa, HA; Jiang, H; Xu, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14777&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search CIA 110635 46515102 71940 CHEMBL779 DB00820 7299 ZINC03993855 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51287610 CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1 InChI=1S/C24H35N5O3/c1-5-14-32-21-9-8-17(25-22(30)16-29-12-10-28(4)11-13-29)15-19(21)23-26-20(7-3)18(6-2)24(31)27-23/h8-9,15H,5-7,10-14,16H2,1-4H3,(H,25,30)(H,26,27,31) PIOIVHHIGWTEJQ-UHFFFAOYSA-N 50525060 CHEMBL4462192 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 20 ChEMBL 10.1021/acs.jmedchem.9b00123 10.7270/Q2T72MWB 31021628 Wang, Z; Jiang, X; Zhang, X; Tian, G; Yang, R; Wu, J; Zou, X; Liu, Z; Yang, X; Wu, C; Shi, J; Li, J; Suo, J; Wang, Y; Zhang, R; Xu, Z; Gong, X; He, Y; Zhu, W; Aisa, HA; Jiang, H; Xu, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525060&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search B0C 136197286 440733642 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51287620 CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) BNRNXUUZRGQAQC-UHFFFAOYSA-N 14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 36 ChEMBL 10.1021/acs.jmedchem.9b00123 10.7270/Q2T72MWB 31021628 Wang, Z; Jiang, X; Zhang, X; Tian, G; Yang, R; Wu, J; Zou, X; Liu, Z; Yang, X; Wu, C; Shi, J; Li, J; Suo, J; Wang, Y; Zhang, R; Xu, Z; Gong, X; He, Y; Zhu, W; Aisa, HA; Jiang, H; Xu, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search VIA 5212 46514731 9139 CHEMBL192 4743 C07259 ZINC19796168 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51334197 C[C@@H](Nc1nc2n(ncc2c(=O)n1Cc1ccc(F)cc1)C(C)(C)C)c1ccc(Cl)cc1 InChI=1S/C24H25ClFN5O/c1-15(17-7-9-18(25)10-8-17)28-23-29-21-20(13-27-31(21)24(2,3)4)22(32)30(23)14-16-5-11-19(26)12-6-16/h5-13,15H,14H2,1-4H3,(H,28,29)/t15-/m1/s1 BOOYHBPHFVNWNH-OAHLLOKOSA-N 50540044 CHEMBL4644729 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c00711 10.7270/Q20V8HBZ 32603117 Wu, Y; Tian, YJ; Le, ML; Zhang, SR; Zhang, C; Huang, MX; Jiang, MY; Zhang, B; Luo, HB Sun Yat-sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540044&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 154699442 442141607 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51388206 COc1ccc2c3CCN4[C@H](N(C)c5cccc(OC)c5C4=O)c3[nH]c2c1 50560855 CHEMBL4745832 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >150000 ChEMBL 10.1021/acs.jmedchem.0c00983 10.7270/Q2668HWF 32794708 Zhang, T; Lai, Z; Yuan, S; Huang, YY; Dong, G; Sheng, C; Ke, H; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50560855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50560855&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 162648094 461831247 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51388207 COc1cccc2N(C)[C@H]3N(CCc4c3[nH]c3cccc(OC)c43)C(=O)c12 50560857 CHEMBL4794748 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >40000 ChEMBL 10.1021/acs.jmedchem.0c00983 10.7270/Q2668HWF 32794708 Zhang, T; Lai, Z; Yuan, S; Huang, YY; Dong, G; Sheng, C; Ke, H; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50560857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50560857&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search FZA 155804436 461831249 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51388208 COc1cccc2N(C)C3N(CCc4c3[nH]c3ccccc43)C(=O)c12 50560848 4-Methoxyevodiamine::CHEMBL2171791 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >20000 ChEMBL 10.1021/acs.jmedchem.0c00983 10.7270/Q2668HWF 32794708 Zhang, T; Lai, Z; Yuan, S; Huang, YY; Dong, G; Sheng, C; Ke, H; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50560848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50560848&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 56967938 461831240 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51388209 COc1cccc2N(C)[C@H]3N(CCc4c3[nH]c3ccccc43)C(=O)c12 50560849 CHEMBL4782533 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >20000 ChEMBL 10.1021/acs.jmedchem.0c00983 10.7270/Q2668HWF 32794708 Zhang, T; Lai, Z; Yuan, S; Huang, YY; Dong, G; Sheng, C; Ke, H; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50560849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50560849&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 162664349 461831241 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51388210 CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12 InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3 TXDUTHBFYKGSAH-UHFFFAOYSA-N 50016250 CHEMBL81925 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >20000 ChEMBL 10.1021/acs.jmedchem.0c00983 10.7270/Q2668HWF 32794708 Zhang, T; Lai, Z; Yuan, S; Huang, YY; Dong, G; Sheng, C; Ke, H; Luo, HB Sun Yat-Sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016250&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 151289 242041529 CHEMBL81925 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51402159 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)NCCO)c1ccccc1C InChI=1S/C26H27N3O3/c1-18-5-3-4-6-23(18)24-17-25(19-9-13-22(32-2)14-10-19)29(28-24)21-11-7-20(8-12-21)26(31)27-15-16-30/h3-14,25,30H,15-17H2,1-2H3,(H,27,31) IAANKOGQBDQYIA-UHFFFAOYSA-N 50566432 CHEMBL4861917 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566432&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 164619506 471056577 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51402160 COc1c(F)cc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)C(C)(C)C InChI=1S/C26H32F2N4O2/c1-26(2,3)23-16-22(18-14-20(27)24(34-5)21(28)15-18)32(29-23)19-8-6-17(7-9-19)25(33)31-12-10-30(4)11-13-31/h6-9,14-15,22H,10-13,16H2,1-5H3 UTEKZOROJZXCET-UHFFFAOYSA-N 50566435 CHEMBL4872902 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566435&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 164622052 471056580 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51402161 COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H32N4O2/c1-21-6-4-5-7-26(21)27-20-28(22-10-14-25(35-3)15-11-22)33(30-27)24-12-8-23(9-13-24)29(34)32-18-16-31(2)17-19-32/h4-15,28H,16-20H2,1-3H3 JEPQMOXLJIDDMY-UHFFFAOYSA-N 50566438 CHEMBL4852714 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566438&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 164611751 471056583 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51402162 COc1ccc(cc1F)C1CC(=NN1c1ccc(cc1)C(=O)N1CCN(C)CC1)c1ccccc1C InChI=1S/C29H31FN4O2/c1-20-6-4-5-7-24(20)26-19-27(22-10-13-28(36-3)25(30)18-22)34(31-26)23-11-8-21(9-12-23)29(35)33-16-14-32(2)15-17-33/h4-13,18,27H,14-17,19H2,1-3H3 YKESFJBBYRLROW-UHFFFAOYSA-N 50566439 CHEMBL4869439 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566439&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 164618519 471056584 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51402163 COc1ccc(C2CC(=NN2c2ccc(cc2)C(=O)N2CCN(C)CC2)C(C)(C)C)c(F)c1F InChI=1S/C26H32F2N4O2/c1-26(2,3)22-16-20(19-10-11-21(34-5)24(28)23(19)27)32(29-22)18-8-6-17(7-9-18)25(33)31-14-12-30(4)13-15-31/h6-11,20H,12-16H2,1-5H3 INLXRJLYIMPNFU-UHFFFAOYSA-N 50566443 CHEMBL4879176 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >10000 ChEMBL 10.1021/acs.jmedchem.0c01120 10.7270/Q2765K34 33793216 Abdel-Halim, M; Sigler, S; Racheed, NAS; Hefnawy, A; Fathalla, RK; Hammam, MA; Maher, A; Maxuitenko, Y; Keeton, AB; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH German University in Cairo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50566443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50566443&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search 164628091 471056588 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29 51410855 COc1cc2CCN(C=O)[C@@H](Cc3c[nH]c4c(Cl)cccc34)c2cc1OC 50569910 CHEMBL4848137 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' >5000 ChEMBL 10.1016/j.ejmech.2020.113004 10.7270/Q20P13TW 33218684 Zhang, R; Li, H; Zhang, X; Li, J; Su, H; Lu, Q; Dong, G; Dou, H; Fan, C; Gu, Z; Mu, Q; Tang, W; Xu, Y; Liu, H Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7940&target=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569910&enzyme=Cone+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+subunit+alpha%27&column=ki&startPg=0&Increment=50&submit=Search FTX 155923496 471060055 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' PDE6C_HUMAN P51160 A6NCR6 Q5VY29