BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 336628 C(CN1CCO[C@@H](COc2ccccn2)C1)N1CCc2ccccc12 InChI=1S/C20H25N3O2/c1-2-6-19-17(5-1)8-10-23(19)12-11-22-13-14-24-18(15-22)16-25-20-7-3-4-9-21-20/h1-7,9,18H,8,10-16H2/t18-/m1/s1 DSTWBFPFQZUGGQ-GOSISDBHSA-N 186923 US9079895, 15r D(4) dopamine receptor 814 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186923&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062829 315662710 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336629 Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C21H27N3O2/c1-17-6-8-22-21(14-17)26-16-19-15-23(12-13-25-19)10-11-24-9-7-18-4-2-3-5-20(18)24/h2-6,8,14,19H,7,9-13,15-16H2,1H3/t19-/m1/s1 XEESQZOHNMFSPW-LJQANCHMSA-N 186925 US9079895, 17r D(4) dopamine receptor 1931 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186925&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062567 315662712 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336630 O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc12 InChI=1S/C21H24N2O3/c24-21(23-11-10-17-6-4-5-9-20(17)23)15-22-12-13-25-19(14-22)16-26-18-7-2-1-3-8-18/h1-9,19H,10-16H2/t19-/m0/s1 QTIAESZAMKLZSK-IBGZPJMESA-N 186926 US9079895, 18s D(4) dopamine receptor 5526 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186926&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062560 315662713 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336631 C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc12 InChI=1S/C21H26N2O2/c1-2-7-19(8-3-1)25-17-20-16-22(14-15-24-20)12-13-23-11-10-18-6-4-5-9-21(18)23/h1-9,20H,10-17H2/t20-/m0/s1 ZKTUDHGKQCWRDH-FQEVSTJZSA-N 186927 US9079895, 19s D(4) dopamine receptor 132 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186927&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062646 315662714 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336632 C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc12 InChI=1S/C20H25N3O2/c1-2-6-20-17(4-1)7-9-23(20)11-10-22-12-13-24-19(15-22)16-25-18-5-3-8-21-14-18/h1-6,8,14,19H,7,9-13,15-16H2/t19-/m1/s1 NVTIHTIPOLNIHA-LJQANCHMSA-N 186929 US9079895, 21r D(4) dopamine receptor 2406 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186929&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71086389 315662716 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336633 O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc12 InChI=1S/C20H23N3O3/c24-20(23-9-7-16-4-1-2-6-19(16)23)14-22-10-11-25-18(13-22)15-26-17-5-3-8-21-12-17/h1-6,8,12,18H,7,9-11,13-15H2/t18-/m0/s1 XYHRHHHLNLGIRG-SFHVURJKSA-N 186930 US9079895, 20s::US9079895, 21s D(4) dopamine receptor 182 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186930&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062889 315662717 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336634 Clc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc34)CCO2)c1 InChI=1S/C21H23ClN2O3/c22-17-5-3-6-18(12-17)27-15-19-13-23(10-11-26-19)14-21(25)24-9-8-16-4-1-2-7-20(16)24/h1-7,12,19H,8-11,13-15H2/t19-/m1/s1 APCQYPHUPXTFSO-LJQANCHMSA-N 186932 US9079895, 22r D(4) dopamine receptor 536 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186932&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061785 315662718 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336635 Clc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc34)CCO2)c1 InChI=1S/C21H23ClN2O3/c22-17-5-3-6-18(12-17)27-15-19-13-23(10-11-26-19)14-21(25)24-9-8-16-4-1-2-7-20(16)24/h1-7,12,19H,8-11,13-15H2/t19-/m0/s1 APCQYPHUPXTFSO-IBGZPJMESA-N 186934 US9079895, 22s D(4) dopamine receptor 2858 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186934&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061724 315662720 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336636 Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C21H25ClN2O2/c22-18-5-3-6-19(14-18)26-16-20-15-23(12-13-25-20)10-11-24-9-8-17-4-1-2-7-21(17)24/h1-7,14,20H,8-13,15-16H2/t20-/m1/s1 QAJBOIGVHPCSNX-HXUWFJFHSA-N 186933 US9079895, 23r D(4) dopamine receptor 1666 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186933&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061729 315662719 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336637 Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C21H25ClN2O2/c22-18-5-3-6-19(14-18)26-16-20-15-23(12-13-25-20)10-11-24-9-8-17-4-1-2-7-21(17)24/h1-7,14,20H,8-13,15-16H2/t20-/m0/s1 QAJBOIGVHPCSNX-FQEVSTJZSA-N 186935 US9079895, 23s D(4) dopamine receptor 146 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186935&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061709 315662721 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336638 COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc34)CCO2)c1 InChI=1S/C22H26N2O4/c1-26-18-6-4-7-19(13-18)28-16-20-14-23(11-12-27-20)15-22(25)24-10-9-17-5-2-3-8-21(17)24/h2-8,13,20H,9-12,14-16H2,1H3/t20-/m1/s1 KJWABLDVLWKPKR-HXUWFJFHSA-N 186938 US9079895, 25r D(4) dopamine receptor 2486 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186938&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 90181059 315662724 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336639 COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C22H28N2O3/c1-25-19-6-4-7-20(15-19)27-17-21-16-23(13-14-26-21)11-12-24-10-9-18-5-2-3-8-22(18)24/h2-8,15,21H,9-14,16-17H2,1H3/t21-/m0/s1 ROKNCKQMECSPFV-NRFANRHFSA-N 186937 US9079895, 25s D(4) dopamine receptor 3362 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186937&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062708 315662723 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336640 Cc1ncccc1OC[C@@H]1CN(CCN2CCc3ccccc23)CCO1 InChI=1S/C21H27N3O2/c1-17-21(7-4-9-22-17)26-16-19-15-23(13-14-25-19)11-12-24-10-8-18-5-2-3-6-20(18)24/h2-7,9,19H,8,10-16H2,1H3/t19-/m0/s1 DYMQPSSXRFHPQS-IBGZPJMESA-N 186940 US9079895, 26s D(4) dopamine receptor 435 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186940&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062664 315662726 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336641 Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C20H24ClN3O2/c21-17-11-18(13-22-12-17)26-15-19-14-23(9-10-25-19)7-8-24-6-5-16-3-1-2-4-20(16)24/h1-4,11-13,19H,5-10,14-15H2/t19-/m1/s1 QURJBQQAYVMKHZ-LJQANCHMSA-N 186941 US9079895, 27r D(4) dopamine receptor 3618 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186941&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71086303 315662727 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336642 Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)c1 InChI=1S/C20H24ClN3O2/c21-17-11-18(13-22-12-17)26-15-19-14-23(9-10-25-19)7-8-24-6-5-16-3-1-2-4-20(16)24/h1-4,11-13,19H,5-10,14-15H2/t19-/m0/s1 QURJBQQAYVMKHZ-IBGZPJMESA-N 186942 US9079895, 27s D(4) dopamine receptor 90 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186942&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71086428 315662728 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336643 Cc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)cn1 InChI=1S/C21H27N3O2/c1-17-6-7-19(14-22-17)26-16-20-15-23(12-13-25-20)10-11-24-9-8-18-4-2-3-5-21(18)24/h2-7,14,20H,8-13,15-16H2,1H3/t20-/m0/s1 DQFUJEZGAUMKKT-FQEVSTJZSA-N 186944 US9079895, 28s D(4) dopamine receptor 503 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186944&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71062579 315662730 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336644 Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc23)CCO1 InChI=1S/C22H29N3O2/c1-17-7-9-23-18(2)22(17)27-16-20-15-24(13-14-26-20)11-12-25-10-8-19-5-3-4-6-21(19)25/h3-7,9,20H,8,10-16H2,1-2H3/t20-/m1/s1 HPLSCEVPHLQHEB-HXUWFJFHSA-N 186945 US9079895, 29r D(4) dopamine receptor 4947 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186945&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061585 315662731 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336645 Fc1ccc(OC[C@@H]2CN(CCN3CCc4ccccc34)CCO2)cc1 InChI=1S/C21H25FN2O2/c22-18-5-7-19(8-6-18)26-16-20-15-23(13-14-25-20)11-12-24-10-9-17-3-1-2-4-21(17)24/h1-8,20H,9-16H2/t20-/m0/s1 RTXIZQIIOLWLRO-FQEVSTJZSA-N 186969 US9079895, 32s D(4) dopamine receptor 3926 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186969&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71061611 315662743 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4 336646 CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1 InChI=1S/C22H25ClN2O3/c1-16-11-17-5-2-3-8-21(17)25(16)22(26)14-24-9-10-27-20(13-24)15-28-19-7-4-6-18(23)12-19/h2-8,12,16,20H,9-11,13-15H2,1H3/t16?,20-/m0/s1 XRYWJXIFEBMFIK-FZCLLLDFSA-N 186962 US9079895, 64 D(4) dopamine receptor 2394 7.4 US Patent 10.7270/Q2D7996K aid1801769 US9079895 Besnard, J; Hopkins, AL; Gilbert, I; Ruda, GF; Abecassis, K University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=186962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7893&target=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=186962&enzyme=D%284%29+dopamine+receptor&column=ki&startPg=0&Increment=50&submit=Search 71618702 315662736 1 MGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC D(4) dopamine receptor DRD4_MOUSE P51436 O35838 Q7TT80 Q8BXS4