BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 74845 OB(O)c1cccc(NS(=O)(=O)c2cc(cs2)S(=O)(=O)c2ccccc2)c1 InChI=1S/C16H14BNO6S3/c19-17(20)12-5-4-6-13(9-12)18-27(23,24)16-10-15(11-25-16)26(21,22)14-7-2-1-3-8-14/h1-11,18-20H YZOKHYPIQNIFRQ-UHFFFAOYSA-N 50115616 3-(4-BENZENESULFONYL-THIOPHENE-2-SULFONYLAMINO)-PHENYLBORONIC ACID::4-Benzenesulfonyl-thiophene-2-sulfonic acid (3-dihydroxyboranyl-phenyl)-amide::Amide and sulfonamide derivatives, 2::Aza-boronic acid derivative::CHEMBL113381 Beta-lactamase TEM 5.81e+4 7 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00034-5 10.7270/Q27M06BZ 11410378 aid1799472 Tondi, D; Powers, RA; Caselli, E; Negri, MC; Blázquez, J; Costi, MP; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115616&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search ETP 1GA9 1475 104009505 CHEMBL113381 DB02858 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 74848 OB(O)c1cccc(NS(=O)(=O)c2cccc(c2)S(=O)(=O)Nc2cccc(c2)B(O)O)c1 InChI=1S/C18H18B2N2O8S2/c23-19(24)13-4-1-6-15(10-13)21-31(27,28)17-8-3-9-18(12-17)32(29,30)22-16-7-2-5-14(11-16)20(25)26/h1-12,21-26H BKZJNYNXBZSUPD-UHFFFAOYSA-N 39849 Amide and sulfonamide derivatives, 33 Beta-lactamase TEM 7.3e+3 7 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00034-5 10.7270/Q27M06BZ 11410378 aid1799472 Tondi, D; Powers, RA; Caselli, E; Negri, MC; Blázquez, J; Costi, MP; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39849&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9804998 123080157 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 74851 OB(O)c1cccc(NS(=O)(=O)c2cccc(NS(=O)(=O)c3ccc(cc3)C(O)=O)c2)c1 InChI=1S/C19H17BN2O8S2/c23-19(24)13-7-9-17(10-8-13)31(27,28)22-16-5-2-6-18(12-16)32(29,30)21-15-4-1-3-14(11-15)20(25)26/h1-12,21-22,25-26H,(H,23,24) SXBYWLSPXCJQIF-UHFFFAOYSA-N 39856 Amide and sulfonamide derivatives, 41 Beta-lactamase TEM 2.5e+3 7 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00034-5 10.7270/Q27M06BZ 11410378 aid1799472 Tondi, D; Powers, RA; Caselli, E; Negri, MC; Blázquez, J; Costi, MP; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39856&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9869567 123080164 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 235382 COC(=O)C1N2[C@@H](CC2=O)O\C1=C(/C\C=C\c1ccccc1)C=O InChI=1S/C18H17NO5/c1-23-18(22)16-17(24-15-10-14(21)19(15)16)13(11-20)9-5-8-12-6-3-2-4-7-12/h2-8,11,15-16H,9-10H2,1H3/b8-5+,17-13+/t15-,16?/m1/s1 CRIIDFPLOBDCDK-IESOIDBDSA-N 60600 US9120808, Example 13 Beta-lactamase TEM 639.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60600&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 16189294 24787944 ZINC15962133 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324226 CCCC1(N2[C@@H](CC2=O)OC1=CCO)C([O-])=O InChI=1S/C11H15NO5/c1-2-4-11(10(15)16)7(3-5-13)17-9-6-8(14)12(9)11/h3,9,13H,2,4-6H2,1H3,(H,15,16)/p-1/b7-3+/t9-,11?/m1/s1 FPJUOUJTKUOLCV-ISDAKNICSA-M 178213 US9120808, Example 56 Beta-lactamase TEM 17789 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178213&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987487 313063568 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324229 COC(=O)C1N2[C@@H](CC2=O)OC1=C(CCCc1ccccc1)C(=O)OC InChI=1S/C19H21NO6/c1-24-18(22)13(10-6-9-12-7-4-3-5-8-12)17-16(19(23)25-2)20-14(21)11-15(20)26-17/h3-5,7-8,15-16H,6,9-11H2,1-2H3/b17-13-/t15-,16?/m1/s1 WUZOFCVGXRSCHI-VLCNFMPYSA-N 178214 US9120808, Example 57 Beta-lactamase TEM 10.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178214&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987488 313063569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324232 OC(=O)C(CC=CCN(Cc1ccccc1)C(=O)OCc1ccccc1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C34H32N2O8/c37-28-20-29-36(28)30(33(40)42-22-25-14-6-2-7-15-25)31(44-29)27(32(38)39)18-10-11-19-35(21-24-12-4-1-5-13-24)34(41)43-23-26-16-8-3-9-17-26/h1-17,29-30H,18-23H2,(H,38,39)/b11-10+,31-27-/t29-,30?/m1/s1 HXKNILWLBVUKER-SUVRPQBXSA-N 178215 US9120808, Example 58 Beta-lactamase TEM 1.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178215&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987489 313063570 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324235 ICC1CC(CO1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H18INO5/c19-8-13-6-12(10-23-13)17-16(20-14(21)7-15(20)25-17)18(22)24-9-11-4-2-1-3-5-11/h1-5,13,15-16H,6-10H2/t13?,15-,16?/m1/s1 GWGNBTHOPHGFDX-OGVSOVDVSA-N 178180 US9120808, Example 59 Beta-lactamase TEM 4392.3 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178180&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663046 313063541 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324100 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 29.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324103 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 1065.9 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324106 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 17.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324108 C=CCC(C=O)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H17NO5/c1-2-6-13(10-20)17-16(19-14(21)9-15(19)24-17)18(22)23-11-12-7-4-3-5-8-12/h2-5,7-8,10,15-16H,1,6,9,11H2/b17-13-/t15-,16?/m1/s1 LSWFYHUYIAXPOB-VLCNFMPYSA-N 178182 US9120808, Example 1 Beta-lactamase TEM 66.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178182&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987468 313063542 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324110 C=CCC1(N2[C@@H](CC2=O)OC1=CC=O)C(=O)OCc1ccccc1 InChI=1S/C18H17NO5/c1-2-9-18(17(22)23-12-13-6-4-3-5-7-13)14(8-10-20)24-16-11-15(21)19(16)18/h2-8,10,16H,1,9,11-12H2/b14-8+/t16-,18?/m1/s1 SPTMQRZXEWVYFQ-LGJWTYRLSA-N 178183 US9120808, Example 2 Beta-lactamase TEM 945.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178183&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 88879666 313063543 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324112 C=CCC(C=O)=C1O[C@@H]2CC(=O)N2C1(CC=C)C(=O)OCc1ccccc1 InChI=1S/C21H21NO5/c1-3-8-16(13-23)19-21(11-4-2,22-17(24)12-18(22)27-19)20(25)26-14-15-9-6-5-7-10-15/h3-7,9-10,13,18H,1-2,8,11-12,14H2/b19-16-/t18-,21?/m1/s1 RNEZBAWBDZGLDN-CGLKDYMESA-N 178184 US9120808, Example 3 Beta-lactamase TEM 8386.3 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178184&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987469 313063544 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324114 O=CC(CC=Cc1ccccc1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C24H21NO5/c26-15-19(13-7-12-17-8-3-1-4-9-17)23-22(25-20(27)14-21(25)30-23)24(28)29-16-18-10-5-2-6-11-18/h1-12,15,21-22H,13-14,16H2/b12-7+,23-19-/t21-,22?/m1/s1 NMQXSANBHIOUJJ-TYJSTWMOSA-N 178185 US9120808, Example 4 Beta-lactamase TEM 89 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178185&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987470 313063545 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324117 O=CC=C1O[C@@H]2CC(=O)N2C1(CC=Cc1ccccc1)C(=O)OCc1ccccc1 InChI=1S/C24H21NO5/c26-15-13-20-24(25-21(27)16-22(25)30-20,14-7-12-18-8-3-1-4-9-18)23(28)29-17-19-10-5-2-6-11-19/h1-13,15,22H,14,16-17H2/b12-7+,20-13-/t22-,24?/m1/s1 KBUJSCWFZMYQLR-QQKZXBOMSA-N 178186 US9120808, Example 5::US9120808, Example 6 Beta-lactamase TEM 4923.3 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178186&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118181206 313063546 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324120 O=CC=C1O[C@@H]2CC(=O)N2C1(CC=Cc1ccccc1)C(=O)OCc1ccccc1 InChI=1S/C24H21NO5/c26-15-13-20-24(25-21(27)16-22(25)30-20,14-7-12-18-8-3-1-4-9-18)23(28)29-17-19-10-5-2-6-11-19/h1-13,15,22H,14,16-17H2/b12-7+,20-13-/t22-,24?/m1/s1 KBUJSCWFZMYQLR-QQKZXBOMSA-N 178186 US9120808, Example 5::US9120808, Example 6 Beta-lactamase TEM 2792.3 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178186&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118181206 313063546 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324123 OCC=CCC(C=O)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C19H19NO6/c21-9-5-4-8-14(11-22)18-17(20-15(23)10-16(20)26-18)19(24)25-12-13-6-2-1-3-7-13/h1-7,11,16-17,21H,8-10,12H2/b5-4+,18-14-/t16-,17?/m1/s1 PIPGAOFSHNWTAH-QGNNKKJBSA-N 178188 US9120808, Example 7 Beta-lactamase TEM 78.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178188&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987471 313063547 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324125 OCC=CCC1(N2[C@@H](CC2=O)OC1=CC=O)C(=O)OCc1ccccc1 InChI=1S/C19H19NO6/c21-10-5-4-9-19(18(24)25-13-14-6-2-1-3-7-14)15(8-11-22)26-17-12-16(23)20(17)19/h1-8,11,17,21H,9-10,12-13H2/b5-4-,15-8-/t17-,19?/m1/s1 PODACQWVDNEGKW-WMYCVDERSA-N 178189 US9120808, Example 8::US9120808, Example 9 Beta-lactamase TEM 5642.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178189&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987472 313063548 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324128 OCC=CCC1(N2[C@@H](CC2=O)OC1=CC=O)C(=O)OCc1ccccc1 InChI=1S/C19H19NO6/c21-10-5-4-9-19(18(24)25-13-14-6-2-1-3-7-14)15(8-11-22)26-17-12-16(23)20(17)19/h1-8,11,17,21H,9-10,12-13H2/b5-4-,15-8-/t17-,19?/m1/s1 PODACQWVDNEGKW-WMYCVDERSA-N 178189 US9120808, Example 8::US9120808, Example 9 Beta-lactamase TEM 827.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178189&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987472 313063548 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324130 CC(=O)OCC=CCC(C=O)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C21H21NO7/c1-14(24)27-10-6-5-9-16(12-23)20-19(22-17(25)11-18(22)29-20)21(26)28-13-15-7-3-2-4-8-15/h2-8,12,18-19H,9-11,13H2,1H3/b6-5+,20-16-/t18-,19?/m1/s1 OUNQKFHIKDLFII-FTVIDMELSA-N 178191 US9120808, Example 10 Beta-lactamase TEM 139.9 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178191&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987473 313063549 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324132 CC(=O)OCC=CCC1(N2[C@@H](CC2=O)OC1=CC=O)C(=O)OCc1ccccc1 InChI=1S/C21H21NO7/c1-15(24)27-12-6-5-10-21(20(26)28-14-16-7-3-2-4-8-16)17(9-11-23)29-19-13-18(25)22(19)21/h2-9,11,19H,10,12-14H2,1H3/b6-5-,17-9-/t19-,21?/m1/s1 BGQRDDSRQMAZIR-YDJAWIAZSA-N 178192 US9120808, Example 11::US9120808, Example 12 Beta-lactamase TEM 7306.7 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178192&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118343670 313063550 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324134 CC(=O)OCC=CCC1(N2[C@@H](CC2=O)OC1=CC=O)C(=O)OCc1ccccc1 InChI=1S/C21H21NO7/c1-15(24)27-12-6-5-10-21(20(26)28-14-16-7-3-2-4-8-16)17(9-11-23)29-19-13-18(25)22(19)21/h2-9,11,19H,10,12-14H2,1H3/b6-5-,17-9-/t19-,21?/m1/s1 BGQRDDSRQMAZIR-YDJAWIAZSA-N 178192 US9120808, Example 11::US9120808, Example 12 Beta-lactamase TEM 5897.7 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178192&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118343670 313063550 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324137 COC(=O)C1(CC=Cc2ccccc2)N2[C@@H](CC2=O)OC1=CC=O InChI=1S/C18H17NO5/c1-23-17(22)18(10-5-8-13-6-3-2-4-7-13)14(9-11-20)24-16-12-15(21)19(16)18/h2-9,11,16H,10,12H2,1H3/b8-5+,14-9+/t16-,18?/m1/s1 VWSIAIDFEKNQNE-SRNKDFPPSA-N 178194 US9120808, Example 14::US9120808, Example 15 Beta-lactamase TEM 19632 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178194&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 88879655 313063551 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324140 COC(=O)C1(CC=Cc2ccccc2)N2[C@@H](CC2=O)OC1=CC=O InChI=1S/C18H17NO5/c1-23-17(22)18(10-5-8-13-6-3-2-4-7-13)14(9-11-20)24-16-12-15(21)19(16)18/h2-9,11,16H,10,12H2,1H3/b8-5+,14-9+/t16-,18?/m1/s1 VWSIAIDFEKNQNE-SRNKDFPPSA-N 178194 US9120808, Example 14::US9120808, Example 15 Beta-lactamase TEM 4268.3 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178194&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 88879655 313063551 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324143 COC(=O)C1N2[C@@H](CC2=O)OC1=C(CC=C)C=O InChI=1S/C12H13NO5/c1-3-4-7(6-14)11-10(12(16)17-2)13-8(15)5-9(13)18-11/h3,6,9-10H,1,4-5H2,2H3/b11-7-/t9-,10?/m1/s1 HLBYYYVPQDVZIQ-XETXAFAXSA-N 178196 US9120808, Example 16 Beta-lactamase TEM 65.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178196&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987474 313063552 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324146 COC(=O)C1(CC=C)N2[C@@H](CC2=O)OC1=CC=O InChI=1S/C12H13NO5/c1-3-5-12(11(16)17-2)8(4-6-14)18-10-7-9(15)13(10)12/h3-4,6,10H,1,5,7H2,2H3/b8-4+/t10-,12?/m1/s1 WEJZNOFAZVDYFB-FOXUPHSNSA-N 178197 US9120808, Example 17 Beta-lactamase TEM 13259.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178197&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 88879645 313063553 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324149 CC(C)(C)C(=O)OCOC(=O)C1N2[C@@H](CC2=O)OC1=C(CC=Cc1ccccc1)C=O InChI=1S/C23H25NO7/c1-23(2,3)22(28)30-14-29-21(27)19-20(31-18-12-17(26)24(18)19)16(13-25)11-7-10-15-8-5-4-6-9-15/h4-10,13,18-19H,11-12,14H2,1-3H3/b10-7+,20-16-/t18-,19?/m1/s1 XQZUNXLRBIFXDD-XRWPXBKOSA-N 178198 US9120808, Example 18 Beta-lactamase TEM 27.1 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178198&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987475 313063554 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324152 CC(C)(C)C(=O)OCOC(=O)C1(CC=Cc2ccccc2)N2[C@@H](CC2=O)OC1=CC=O InChI=1S/C23H25NO7/c1-22(2,3)20(27)29-15-30-21(28)23(12-7-10-16-8-5-4-6-9-16)17(11-13-25)31-19-14-18(26)24(19)23/h4-11,13,19H,12,14-15H2,1-3H3/b10-7+,17-11-/t19-,23?/m1/s1 RTZMBJMWCNEYEE-HUCLUGSFSA-N 178199 US9120808, Example 19 Beta-lactamase TEM 870.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178199&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987476 313063555 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324155 OC(=O)C(CC=C)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H17NO6/c1-2-6-12(17(21)22)16-15(19-13(20)9-14(19)25-16)18(23)24-10-11-7-4-3-5-8-11/h2-5,7-8,14-15H,1,6,9-10H2,(H,21,22)/b16-12-/t14-,15?/m1/s1 RBWUPNXZJVLGSA-OPGGXJNDSA-N 178200 US9120808, Example 24 Beta-lactamase TEM 30.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178200&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987477 313063556 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324158 OC(=O)C(CC=Cc1ccccc1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C24H21NO6/c26-19-14-20-25(19)21(24(29)30-15-17-10-5-2-6-11-17)22(31-20)18(23(27)28)13-7-12-16-8-3-1-4-9-16/h1-12,20-21H,13-15H2,(H,27,28)/b12-7+,22-18-/t20-,21?/m1/s1 FVJOWYDVEXFNKI-BCMBZQKMSA-N 178201 US9120808, Example 26 Beta-lactamase TEM 9.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178201&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987478 313063557 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324161 OC(=O)C=C1O[C@@H]2CC(=O)N2C1(C\C=C\c1ccccc1)C(=O)OCc1ccccc1 InChI=1S/C24H21NO6/c26-20-15-21-25(20)24(19(31-21)14-22(27)28,13-7-12-17-8-3-1-4-9-17)23(29)30-16-18-10-5-2-6-11-18/h1-12,14,21H,13,15-16H2,(H,27,28)/b12-7+,19-14?/t21-,24?/m1/s1 TXPJIXCYUFODBL-NVXDFMSBSA-N 178145 US9120808, Example 27::US9120808, Example 28 Beta-lactamase TEM 426.1 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178145&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68206075 313063533 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324164 OC(=O)C=C1O[C@@H]2CC(=O)N2C1(C\C=C\c1ccccc1)C(=O)OCc1ccccc1 InChI=1S/C24H21NO6/c26-20-15-21-25(20)24(19(31-21)14-22(27)28,13-7-12-17-8-3-1-4-9-17)23(29)30-16-18-10-5-2-6-11-18/h1-12,14,21H,13,15-16H2,(H,27,28)/b12-7+,19-14?/t21-,24?/m1/s1 TXPJIXCYUFODBL-NVXDFMSBSA-N 178145 US9120808, Example 27::US9120808, Example 28 Beta-lactamase TEM 45684.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178145&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68206075 313063533 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324167 COC(=O)C1N2[C@@H](CC2=O)OC1=C(CC=C)C(O)=O InChI=1S/C12H13NO6/c1-3-4-6(11(15)16)10-9(12(17)18-2)13-7(14)5-8(13)19-10/h3,8-9H,1,4-5H2,2H3,(H,15,16)/b10-6-/t8-,9?/m1/s1 DMUDPEVSVHCUNB-RFFQBLADSA-N 178202 US9120808, Example 32 Beta-lactamase TEM 121.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178202&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987479 313063558 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324170 COC(=O)C1N2[C@@H](CC2=O)OC1=C(CC=Cc1ccccc1)C(O)=O InChI=1S/C18H17NO6/c1-24-18(23)15-16(25-14-10-13(20)19(14)15)12(17(21)22)9-5-8-11-6-3-2-4-7-11/h2-8,14-15H,9-10H2,1H3,(H,21,22)/b8-5+,16-12-/t14-,15?/m1/s1 QEYQIONWPOMBON-CTJIIYQFSA-N 178203 US9120808, Example 34 Beta-lactamase TEM 21.7 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178203&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987480 313063559 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324173 COC(=O)C1(C\C=C\c2ccccc2)N2[C@@H](CC2=O)OC1=CC(O)=O InChI=1S/C18H17NO6/c1-24-17(23)18(9-5-8-12-6-3-2-4-7-12)13(10-16(21)22)25-15-11-14(20)19(15)18/h2-8,10,15H,9,11H2,1H3,(H,21,22)/b8-5+,13-10?/t15-,18?/m1/s1 FJEAGJSMLOQFME-AOEGRYEOSA-N 178153 US9120808, Example 35::US9120808, Example 36 Beta-lactamase TEM 1561.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178153&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68206078 313063534 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324176 COC(=O)C1(C\C=C\c2ccccc2)N2[C@@H](CC2=O)OC1=CC(O)=O InChI=1S/C18H17NO6/c1-24-17(23)18(9-5-8-12-6-3-2-4-7-12)13(10-16(21)22)25-15-11-14(20)19(15)18/h2-8,10,15H,9,11H2,1H3,(H,21,22)/b8-5+,13-10?/t15-,18?/m1/s1 FJEAGJSMLOQFME-AOEGRYEOSA-N 178153 US9120808, Example 35::US9120808, Example 36 Beta-lactamase TEM 407.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178153&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68206078 313063534 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324179 CC(C)(C)C(=O)OCOC(=O)C1N2[C@@H](CC2=O)OC1=C(CC=Cc1ccccc1)C(O)=O InChI=1S/C23H25NO8/c1-23(2,3)22(29)31-13-30-21(28)18-19(32-17-12-16(25)24(17)18)15(20(26)27)11-7-10-14-8-5-4-6-9-14/h4-10,17-18H,11-13H2,1-3H3,(H,26,27)/b10-7+,19-15-/t17-,18?/m1/s1 ZXZLCZGIXSRHMF-PJTZRWQUSA-N 178204 US9120808, Example 37 Beta-lactamase TEM 44.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178204&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987481 313063560 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324182 OCC(CC=C)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H19NO5/c1-2-6-13(10-20)17-16(19-14(21)9-15(19)24-17)18(22)23-11-12-7-4-3-5-8-12/h2-5,7-8,15-16,20H,1,6,9-11H2/b17-13-/t15-,16?/m1/s1 ZUIFBYULLQUXTF-VLCNFMPYSA-N 178205 US9120808, Example 38::US9120808, Example 38a Beta-lactamase TEM 8016 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178205&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663152 313063561 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324185 OCC(CC=C)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H19NO5/c1-2-6-13(10-20)17-16(19-14(21)9-15(19)24-17)18(22)23-11-12-7-4-3-5-8-12/h2-5,7-8,15-16,20H,1,6,9-11H2/b17-13-/t15-,16?/m1/s1 ZUIFBYULLQUXTF-VLCNFMPYSA-N 178205 US9120808, Example 38::US9120808, Example 38a Beta-lactamase TEM 1948.6 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178205&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663152 313063561 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324188 OCC(CC=Cc1ccccc1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C24H23NO5/c26-15-19(13-7-12-17-8-3-1-4-9-17)23-22(25-20(27)14-21(25)30-23)24(28)29-16-18-10-5-2-6-11-18/h1-12,21-22,26H,13-16H2/b12-7+,23-19-/t21-,22?/m1/s1 FAKBCYAIPVOYTK-TYJSTWMOSA-N 178207 US9120808, Example 39 Beta-lactamase TEM 4124.9 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178207&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987482 313063562 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324190 OCC=C1O[C@@H]2CC(=O)N2C1(CC=C)C(=O)OCc1ccccc1 InChI=1S/C18H19NO5/c1-2-9-18(17(22)23-12-13-6-4-3-5-7-13)14(8-10-20)24-16-11-15(21)19(16)18/h2-8,16,20H,1,9-12H2/b14-8+/t16-,18?/m1/s1 ADMWSBHYYMUDFV-LGJWTYRLSA-N 178208 US9120808, Example 40 Beta-lactamase TEM 23621.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178208&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663061 313063563 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324193 ICC1CC(C(=O)O1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H16INO6/c19-8-11-6-12(17(22)25-11)16-15(20-13(21)7-14(20)26-16)18(23)24-9-10-4-2-1-3-5-10/h1-5,11,14-15H,6-9H2/t11?,14-,15?/m1/s1 ROBNSNBYRBBNOO-XGTXGMFGSA-N 178163 US9120808, Example 41::US9120808, Example 42 Beta-lactamase TEM 0.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178163&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663155 313063535 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324196 ICC1CC(C(=O)O1)=C1O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H16INO6/c19-8-11-6-12(17(22)25-11)16-15(20-13(21)7-14(20)26-16)18(23)24-9-10-4-2-1-3-5-10/h1-5,11,14-15H,6-9H2/t11?,14-,15?/m1/s1 ROBNSNBYRBBNOO-XGTXGMFGSA-N 178163 US9120808, Example 41::US9120808, Example 42 Beta-lactamase TEM 1.7 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178163&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663155 313063535 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324199 COC(=O)C1N2[C@@H](CC2=O)O\C1=C1/CC(CI)OC1=O InChI=1S/C12H12INO6/c1-18-12(17)9-10(20-8-3-7(15)14(8)9)6-2-5(4-13)19-11(6)16/h5,8-9H,2-4H2,1H3/b10-6+/t5?,8-,9?/m1/s1 VZTMHDMZOMWRDY-BNGSUFQRSA-N 178165 US9120808, Mixture of Example 43 and Example 44 Beta-lactamase TEM 3.5 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178165&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663100 313063536 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324202 CC1C\C(C(=O)O1)=C1/O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H17NO6/c1-10-7-12(17(21)24-10)16-15(19-13(20)8-14(19)25-16)18(22)23-9-11-5-3-2-4-6-11/h2-6,10,14-15H,7-9H2,1H3/b16-12+/t10?,14-,15?/m1/s1 DVLLKFBRONEGAN-HBEDQSHMSA-N 178167 US9120808, Example 46::US9120808, Example 47 Beta-lactamase TEM 1.7 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178167&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663093 313063537 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324205 CC1C\C(C(=O)O1)=C1/O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H17NO6/c1-10-7-12(17(21)24-10)16-15(19-13(20)8-14(19)25-16)18(22)23-9-11-5-3-2-4-6-11/h2-6,10,14-15H,7-9H2,1H3/b16-12+/t10?,14-,15?/m1/s1 DVLLKFBRONEGAN-HBEDQSHMSA-N 178167 US9120808, Example 46::US9120808, Example 47 Beta-lactamase TEM 0.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178167&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663093 313063537 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324208 [N-]=[N+]=NCC1C\C(C(=O)O1)=C1/O[C@@H]2CC(=O)N2C1C(=O)OCc1ccccc1 InChI=1S/C18H16N4O6/c19-21-20-8-11-6-12(17(24)27-11)16-15(22-13(23)7-14(22)28-16)18(25)26-9-10-4-2-1-3-5-10/h1-5,11,14-15H,6-9H2/b16-12+/t11?,14-,15?/m1/s1 OQJRHYHETOWZLM-HSDDFOLNSA-N 178169 US9120808, Example 48 Beta-lactamase TEM 2.4 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178169&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118343513 313063538 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324211 CC1C\C(C(=O)O1)=C1/O[C@@H]2CC(=O)N2C1C(O)=O InChI=1S/C11H11NO6/c1-4-2-5(11(16)17-4)9-8(10(14)15)12-6(13)3-7(12)18-9/h4,7-8H,2-3H2,1H3,(H,14,15)/b9-5+/t4?,7-,8?/m1/s1 OUWZKDIHVIQMRZ-ZKAZXBEYSA-N 178170 US9120808, Example 49 Beta-lactamase TEM 1.8 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178170&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663092 313063539 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324214 CC1CC(C(=O)O1)=C1O[C@@H]2CC(=O)N2C1C(O)=O InChI=1S/C11H11NO6/c1-4-2-5(11(16)17-4)9-8(10(14)15)12-6(13)3-7(12)18-9/h4,7-8H,2-3H2,1H3,(H,14,15)/t4?,7-,8?/m1/s1 OUWZKDIHVIQMRZ-JSTPGZNOSA-N 178171 US9120808, Example 50 Beta-lactamase TEM 4.2 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178171&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 70663092 313063540 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324217 CCCC(C(O)=O)=C1O[C@@H]2CC(=O)N2C1C(O)=O InChI=1S/C11H13NO6/c1-2-3-5(10(14)15)9-8(11(16)17)12-6(13)4-7(12)18-9/h7-8H,2-4H2,1H3,(H,14,15)(H,16,17)/b9-5-/t7-,8?/m1/s1 QAABSWVJCGWPMP-ITHRYJQJSA-N 178209 US9120808, Example 51 Beta-lactamase TEM 254 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178209&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987483 313063564 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324220 COC(=O)C1N2[C@@H](CC2=O)OC1=C(CCCc1ccccc1)C(O)=O InChI=1S/C18H19NO6/c1-24-18(23)15-16(25-14-10-13(20)19(14)15)12(17(21)22)9-5-8-11-6-3-2-4-7-11/h2-4,6-7,14-15H,5,8-10H2,1H3,(H,21,22)/b16-12-/t14-,15?/m1/s1 XSDSQTYLBBGLJR-OPGGXJNDSA-N 178210 US9120808, Example 53 Beta-lactamase TEM 72.8 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178210&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987484 313063565 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324223 CCCC(C(O)=O)=C1O[C@@H]2CC(=O)N2C1C(=O)OC InChI=1S/C12H15NO6/c1-3-4-6(11(15)16)10-9(12(17)18-2)13-7(14)5-8(13)19-10/h8-9H,3-5H2,1-2H3,(H,15,16)/b10-6-/t8-,9?/m1/s1 ALXADSUETYDFDB-RFFQBLADSA-N 178211 US9120808, Example 54 Beta-lactamase TEM 97 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178211&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987485 313063566 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 324224 CCCC(CO)=C1O[C@@H]2CC(=O)N2C1C([O-])=O InChI=1S/C11H15NO5/c1-2-3-6(5-13)10-9(11(15)16)12-7(14)4-8(12)17-10/h8-9,13H,2-5H2,1H3,(H,15,16)/p-1/b10-6-/t8-,9?/m1/s1 MMKATEMYLYLBTG-RFFQBLADSA-M 178212 US9120808, Example 55 Beta-lactamase TEM 118403 7 37.00 C US Patent 10.7270/Q2Q81BT5 aid1801578 US9120808 Bulusu, AR NABRIVA THERAPEUTICS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=178212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=178212&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 118987486 313063567 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002806 Cc1ccc(CCB(O)O)cc1 InChI=1S/C9H13BO2/c1-8-2-4-9(5-3-8)6-7-10(11)12/h2-5,11-12H,6-7H2,1H3 UCNGPRDZLFWXRL-UHFFFAOYSA-N 50282570 2-(4-Methylphenyl)ethyl boronic acid::CHEMBL20678 Beta-lactamase TEM 58000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282570&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 5106507 104124244 CHEMBL20678 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002807 OB(O)CCc1ccc2ccccc2c1 InChI=1S/C12H13BO2/c14-13(15)8-7-10-5-6-11-3-1-2-4-12(11)9-10/h1-6,9,14-15H,7-8H2 JJMSWOAYYIOHPY-UHFFFAOYSA-N 50282563 2-(2-Naphthyl)ethyl boronic acid::Boronic acid derivative::CHEMBL21848 Beta-lactamase TEM 44000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282563&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274300 104124237 CHEMBL21848 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002808 OB(O)CCc1ccc(Cl)cc1 InChI=1S/C8H10BClO2/c10-8-3-1-7(2-4-8)5-6-9(11)12/h1-4,11-12H,5-6H2 GUFRQVYTEHUFBF-UHFFFAOYSA-N 50282562 2-(4Chlorophenyl)ethyl boronic acid::Boronic acid derivative::CHEMBL21447 Beta-lactamase TEM 41000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282562&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274310 104124236 CHEMBL21447 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002809 O[B-](=[OH+])c1cccc(c1)[N+]([O-])=O InChI=1S/C6H6BNO4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4,9-10H ZNRGSYUVFVNSAW-UHFFFAOYSA-N 50067887 3-NITROPHENYLBORONIC ACID::3-Nitro-phenyl-1-dihydroxyborane::3-Nitrophenyl boronic acid::Boronic acid derivative::CHEMBL20945::m-nitophenyl boronic acid Beta-lactamase TEM 121000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067887&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search NPB 3RXX,1KDS 1677 103962313 CHEMBL20945 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002810 OB(O)c1ccc(Br)cc1 InChI=1S/C6H6BBrO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H QBLFZIBJXUQVRF-UHFFFAOYSA-N 50067892 4-Bromophenyl-boronic acid::4-bromo phenyl boronic acid::4-bromophenyl boronic acid::4-bromophenylboronic acid::Boronic acid derivative::CHEMBL20866 Beta-lactamase TEM 28000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067892&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 79599 103962318 CHEMBL20866 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002811 COc1ccc(cc1)B(O)O InChI=1S/C7H9BO3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5,9-10H,1H3 VOAAEKKFGLPLLU-UHFFFAOYSA-N 26133 (4-methoxyphenyl)boranediol::CHEMBL21427::Phenylboronic Acid, 12 Beta-lactamase TEM 670000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26133&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 201262 56464570 CHEMBL21427 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002812 Cc1cccc(CCB(O)O)c1 InChI=1S/C9H13BO2/c1-8-3-2-4-9(7-8)5-6-10(11)12/h2-4,7,11-12H,5-6H2,1H3 BNIRNKXKNRSRHP-UHFFFAOYSA-N 50282566 2-(3-Methylphenyl)ethyl boronic acid::CHEMBL281606 Beta-lactamase TEM 83000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282566&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274284 104124240 CHEMBL281606 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002813 OB(O)c1ccc(F)c(Cl)c1 InChI=1S/C6H5BClFO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,10-11H WJDZZXIDQYKVDG-UHFFFAOYSA-N 50282573 3-Chloro-4-fluorophenyl boronic acid::CHEMBL279024 Beta-lactamase TEM 152000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282573&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2734660 104124247 CHEMBL279024 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002814 COc1cccc(CCB(O)O)c1 InChI=1S/C9H13BO3/c1-13-9-4-2-3-8(7-9)5-6-10(11)12/h2-4,7,11-12H,5-6H2,1H3 SCTAGQZQNPVBJV-UHFFFAOYSA-N 50282575 2-(3-Methoxyphenyl)ethyl boronic acid::CHEMBL281783 Beta-lactamase TEM 50000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282575&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274299 104124249 CHEMBL281783 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002815 Cc1ccccc1CCB(O)O InChI=1S/C9H13BO2/c1-8-4-2-3-5-9(8)6-7-10(11)12/h2-5,11-12H,6-7H2,1H3 SWHKCKLSVWHSED-UHFFFAOYSA-N 50282572 2-(2-Methylphenyl)ethyl boronic acid::CHEMBL21503 Beta-lactamase TEM 141000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282572&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 4361790 104124246 CHEMBL21503 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002816 OB(O)CCC1CCCCC1 InChI=1S/C8H17BO2/c10-9(11)7-6-8-4-2-1-3-5-8/h8,10-11H,1-7H2 UTDUYVCUESABMU-UHFFFAOYSA-N 50282568 2-Cyclohexylethyl boronic acid::CHEMBL277463 Beta-lactamase TEM 276000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282568&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44228204 104124242 CHEMBL277463 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002817 OB(O)c1ccc(Cl)cc1Cl InChI=1S/C6H5BCl2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,10-11H QNEGDGPAXKYZHZ-UHFFFAOYSA-N 50282564 2,4-Dichlorophenyl boronic acid::2,4-dichloro benzene boronic acid::Boronic acid derivative::CHEMBL20726 Beta-lactamase TEM 94000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282564&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2734659 104124238 CHEMBL20726 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002818 OB(O)c1cccc(c1)-c1ccccc1 InChI=1S/C12H11BO2/c14-13(15)12-8-4-7-11(9-12)10-5-2-1-3-6-10/h1-9,14-15H GOXICVKOZJFRMB-UHFFFAOYSA-N 26126 (3-phenylphenyl)boranediol::Phenylboronic Acid, 5 Beta-lactamase TEM 13900 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26126&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2734315 56464563 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002819 OB(O)CCc1cccc2ccccc12 InChI=1S/C12H13BO2/c14-13(15)9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7,14-15H,8-9H2 NLOFGAWFSZSJFG-UHFFFAOYSA-N 50282574 2-(1-Naphthyl)ethyl boronic acid::CHEMBL20434 Beta-lactamase TEM 101000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282574&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44273981 104124248 CHEMBL20434 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002820 OB(O)c1ccc(Cl)c(Cl)c1 InChI=1S/C6H5BCl2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H JKIGHOARKAIPJI-UHFFFAOYSA-N 50282567 3,4-Dichlorophenyl boronic acid::3,4-dichloro benzene boronic acid::CHEMBL20776::Phenylboronic acid, 9 Beta-lactamase TEM 143000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282567&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2734330 104124241 CHEMBL20776 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002821 OB(O)c1ccccc1 InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H HXITXNWTGFUOAU-UHFFFAOYSA-N 26996 CHEMBL21485::PhB(OH)2::Phenyl-boronic acid::Phenylboronic acid, 22::benzeneboronic acid::phenylboranediol::phenylboronic acid Beta-lactamase TEM 491000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26996&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search PBC 6VIM,1JU3,6UQU,4OB0,2A32 66827 57298706 44923 CHEMBL21485 DB01795 C16200 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002822 Nc1cccc(c1)B(O)O InChI=1S/C6H8BNO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H,8H2 JMZFEHDNIAQMNB-UHFFFAOYSA-N 50067906 (3-aminophenyl)boronic acid, 1::3-aminophenyl boronic acid::3-aminophenylboronic acid::Aza-boronic acid derivative::Boronic acid derivative::CHEMBL20852::M-AMINOPHENYLBORONIC ACID Beta-lactamase TEM 3700000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067906&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search APB 4LV0,4E6W,3BLS 92269 103962332 CHEMBL20852 DB01896 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002823 OB(O)CCc1ccccc1Cl InChI=1S/C8H10BClO2/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-4,11-12H,5-6H2 AJQTYJLXOACNAP-UHFFFAOYSA-N 50282565 2-(2-Chlorophenyl)ethyl boronic acid::CHEMBL279974 Beta-lactamase TEM 106000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282565&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274258 104124239 CHEMBL279974 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002824 OB(O)CCc1ccccc1 InChI=1S/C8H11BO2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5,10-11H,6-7H2 VPRUMANMDWQMNF-UHFFFAOYSA-N 26142 (2-phenylethyl)boranediol::Alkylboronic Acid, 21 Beta-lactamase TEM 29800 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26142&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search PBA 6CHA 65389 56464579 DB01963 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002825 OB(O)CCc1ccc(cc1)C(F)(F)F InChI=1S/C9H10BF3O2/c11-9(12,13)8-3-1-7(2-4-8)5-6-10(14)15/h1-4,14-15H,5-6H2 FSBSBSOGFYWNRU-UHFFFAOYSA-N 50282569 2-(4-Trifluoromethylphenyl)ethyl boronic acid::CHEMBL20560 Beta-lactamase TEM 43000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282569&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44273939 104124243 CHEMBL20560 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002826 OB(O)CCc1ccc(cc1)C(O)=O InChI=1S/C9H11BO4/c11-9(12)8-3-1-7(2-4-8)5-6-10(13)14/h1-4,13-14H,5-6H2,(H,11,12) RHVWEVVYPHHZKS-UHFFFAOYSA-N 50282561 2-(4-Carboxyphenyl)ethyI boronic acid::CHEMBL21123 Beta-lactamase TEM 49000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282561&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44273961 104124235 CHEMBL21123 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50002805 OB(O)c1cccc(Br)c1 InChI=1S/C6H6BBrO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H AFSSVCNPDKKSRR-UHFFFAOYSA-N 50282571 3-Bromophenyl boronic acid::CHEMBL278140 Beta-lactamase TEM 83000 ChEMBL 10.1016/S0960-894X(01)80336-X 10.7270/Q2W9595N Martin, R; Gold, M; Jones, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50282571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50282571&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2734318 104124245 CHEMBL278140 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50006853 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 800 ChEMBL 10.1016/S0960-894X(97)00401-0 10.7270/Q2M32VR6 Pfaendler, HR; Weishaupt, R; Medicus, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50006855 C[C@@H](O)[C@@H]1[C@@H]2N(C1=O)C(C([O-])=O)=C(C(C)(C)C)S2(=O)=O InChI=1S/C12H17NO6S/c1-5(14)6-9(15)13-7(11(16)17)8(12(2,3)4)20(18,19)10(6)13/h5-6,10,14H,1-4H3,(H,16,17)/p-1/t5-,6+,10-/m1/s1 ZCVZNXFIILRURF-GOZTUDAPSA-M 50290040 CHEMBL67925::Potassium; (5R,6S)-3-tert-butyl-6-((R)-1-hydroxy-ethyl)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 10000 ChEMBL 10.1016/S0960-894X(97)00401-0 10.7270/Q2M32VR6 Pfaendler, HR; Weishaupt, R; Medicus, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50290040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50290040&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934525 104131611 CHEMBL67925 ZINC26279723 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50006856 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 40 ChEMBL 10.1016/S0960-894X(97)00401-0 10.7270/Q2M32VR6 Pfaendler, HR; Weishaupt, R; Medicus, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50006859 C[C@@H](O)[C@@H]1[C@H]2SC(=C(N2C1=O)C([O-])=O)C(C)(C)C InChI=1S/C12H17NO4S/c1-5(14)6-9(15)13-7(11(16)17)8(12(2,3)4)18-10(6)13/h5-6,10,14H,1-4H3,(H,16,17)/p-1/t5-,6+,10-/m1/s1 YJWBOGUQTYCPBN-GOZTUDAPSA-M 50290039 CHEMBL69141::Potassium; (5R,6S)-3-tert-butyl-6-((R)-1-hydroxy-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 50000 ChEMBL 10.1016/S0960-894X(97)00401-0 10.7270/Q2M32VR6 Pfaendler, HR; Weishaupt, R; Medicus, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50290039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50290039&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934524 104131610 CHEMBL69141 ZINC26280187 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50006862 C[C@@H](O)[C@@H]1[C@@H]2N(C1=O)C(C([O-])=O)=C(S2=O)C(C)(C)C InChI=1S/C12H17NO5S/c1-5(14)6-9(15)13-7(11(16)17)8(12(2,3)4)19(18)10(6)13/h5-6,10,14H,1-4H3,(H,16,17)/p-1/t5-,6+,10-,19?/m1/s1 GSVZWBPOOFMGAJ-PISQCCPLSA-M 50290038 CHEMBL419441::Potassium; (5R,6S)-3-tert-butyl-6-((R)-1-hydroxy-ethyl)-4,7-dioxo-4lambda*4*-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 90000 ChEMBL 10.1016/S0960-894X(97)00401-0 10.7270/Q2M32VR6 Pfaendler, HR; Weishaupt, R; Medicus, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50290038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50290038&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934523 104131609 CHEMBL419441 ZINC26292305 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011966 COC1=C(N2C([C@@H]([C@@H](C)O)C2=O)[C@@H]1C)C([O-])=O InChI=1S/C11H15NO5/c1-4-7-6(5(2)13)10(14)12(7)8(11(15)16)9(4)17-3/h4-7,13H,1-3H3,(H,15,16)/p-1/t4-,5+,6+,7?/m0/s1 XUUNBOUAUWVPDD-CUWOBHIPSA-M 50089775 CHEMBL287670::Potassium; (4S,5R,6S)-6-((R)-1-hydroxy-ethyl)-3-methoxy-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 230 ChEMBL 10.1016/s0960-894x(00)00248-1 10.7270/Q2FN15GX 10890171 Pfaendler, HR; Weishaupt, R; Meffert, H University of Munich http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089775&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931382 103988386 CHEMBL287670 ZINC28771502 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011968 COC1=C(N2[C@H](C1)[C@@H]([C@@H](C)O)C2=O)C([O-])=O InChI=1S/C10H13NO5/c1-4(12)7-5-3-6(16-2)8(10(14)15)11(5)9(7)13/h4-5,7,12H,3H2,1-2H3,(H,14,15)/p-1/t4-,5-,7-/m1/s1 JQVSNQBXQNNKIW-WYDQCIBASA-M 50089777 CHEMBL27621::Potassium; (5R,6S)-6-((R)-1-hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 340000 ChEMBL 10.1016/s0960-894x(00)00248-1 10.7270/Q2FN15GX 10890171 Pfaendler, HR; Weishaupt, R; Meffert, H University of Munich http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089777&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931384 103988388 CHEMBL27621 ZINC03975801 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011969 COC1=C(N2C([C@@H]([C@@H](C)O)C2=O)[C@H]1C)C([O-])=O InChI=1S/C11H15NO5/c1-4-7-6(5(2)13)10(14)12(7)8(11(15)16)9(4)17-3/h4-7,13H,1-3H3,(H,15,16)/p-1/t4-,5-,6-,7?/m1/s1 XUUNBOUAUWVPDD-RKEPMNIXSA-M 50089776 CHEMBL283629::Potassium; (4R,5R,6S)-6-((R)-1-hydroxy-ethyl)-3-methoxy-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 130 ChEMBL 10.1016/s0960-894x(00)00248-1 10.7270/Q2FN15GX 10890171 Pfaendler, HR; Weishaupt, R; Meffert, H University of Munich http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089776&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931383 103988387 CHEMBL283629 ZINC29203515 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011496 CC1(C)S[C@@H]2[C@H](CO)C(=O)N2[C@H]1C([O-])=O InChI=1S/C9H13NO4S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)15-9/h4-5,7,11H,3H2,1-2H3,(H,13,14)/p-1/t4-,5+,7-/m1/s1 DJIMYYWAZIOWRD-JCGDXUMPSA-M 50076675 CHEMBL265722::Sodium; (2S,5R,6R)-6-hydroxymethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 31000 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076675&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931075 103969546 CHEMBL265722 ZINC28096014 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011501 CC1(C)S[C@@H]2[C@@H](CO)C(=O)N2[C@H]1C([O-])=O InChI=1S/C9H13NO4S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)15-9/h4-5,7,11H,3H2,1-2H3,(H,13,14)/p-1/t4-,5-,7+/m0/s1 DJIMYYWAZIOWRD-KZLJYQGOSA-M 50076676 CHEMBL177463::Sodium; (2S,5R,6S)-6-hydroxymethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 59000 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076676&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931076 103969547 CHEMBL177463 ZINC28102870 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011509 CC(C)[C@H](NC[C@H]1OCC[C@H]1SC1=C(N2C([C@@H]([C@@H](C)O)C2=O)[C@H]1C)C(O)=O)C(O)=O InChI=1S/C20H30N2O7S/c1-8(2)14(19(25)26)21-7-11-12(5-6-29-11)30-17-9(3)15-13(10(4)23)18(24)22(15)16(17)20(27)28/h8-15,21,23H,5-7H2,1-4H3,(H,25,26)(H,27,28)/t9-,10-,11-,12-,13-,14+,15?/m1/s1 STUCJEURXSAYOH-OOHKFKTASA-N 50076671 (4R,6S)-3-{(2R,3R)-2-[((S)-1-Carboxy-2-methyl-propylamino)-methyl]-tetrahydro-furan-3-ylsulfanyl}-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid::CHEMBL366664 Beta-lactamase TEM 91 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076671&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44386703 103969542 CHEMBL366664 ZINC28100939 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011512 CC1(C)[C@@H](N2[C@@H]([C@@H](CO)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO6S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)17(9,15)16/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5-,7+/m0/s1 ODGTYAIFNCCEHW-KZLJYQGOSA-N 50076672 (2S,5R,6S)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL24878::Sodium; (2S,5R,6S)-6-hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 8000 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076672&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 15535824 103969543 CHEMBL24878 ZINC28759437 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011513 C[C@@H](O)[C@@H]1[C@@H]2N([C@@H](C([O-])=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C10H15NO6S/c1-4(12)5-7(13)11-6(9(14)15)10(2,3)18(16,17)8(5)11/h4-6,8,12H,1-3H3,(H,14,15)/p-1/t4-,5+,6+,8-/m1/s1 JWBKZXUHEFRKRV-FZGKIIIMSA-M 50076677 CHEMBL177912::Sodium; (2S,5R,6S)-6-((R)-1-hydroxy-ethyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 47900 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076677&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931077 103969548 CHEMBL177912 ZINC28100125 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011514 C[C@H](O)[C@H]1[C@@H]2N([C@@H](C([O-])=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C10H15NO6S/c1-4(12)5-7(13)11-6(9(14)15)10(2,3)18(16,17)8(5)11/h4-6,8,12H,1-3H3,(H,14,15)/p-1/t4-,5+,6-,8+/m0/s1 JWBKZXUHEFRKRV-SKHQTKALSA-M 50076673 CHEMBL175189::Sodium; (2S,5R,6R)-6-((S)-1-hydroxy-ethyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 204000 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076673&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931073 103969544 CHEMBL175189 ZINC28101526 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011515 C[C@H](O)[C@@H]1[C@@H]2N([C@@H](C([O-])=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C10H15NO6S/c1-4(12)5-7(13)11-6(9(14)15)10(2,3)18(16,17)8(5)11/h4-6,8,12H,1-3H3,(H,14,15)/p-1/t4-,5-,6-,8+/m0/s1 JWBKZXUHEFRKRV-VUBPFVNUSA-M 50076674 CHEMBL177772::Sodium; (2S,5R,6S)-6-((S)-1-hydroxy-ethyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM >334000 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076674&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931074 103969545 CHEMBL177772 ZINC28100290 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011526 CC1(C)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO6S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)17(9,15)16/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5+,7-/m1/s1 ODGTYAIFNCCEHW-JCGDXUMPSA-N 50076678 (2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion::CHEMBL416561 Beta-lactamase TEM 8 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076678&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9852179 103969549 CHEMBL416561 ZINC03986689 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011527 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 1400 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011530 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na] InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1 RFMIKMMOLPNEDG-QVUDESDKSA-M 50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum Beta-lactamase TEM 60 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663400 104044614 CHEMBL1439 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011531 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C([O-])=O InChI=1S/C11H14N4O6S/c1-11(5-14-3-2-12-13-14)7(10(18)19)15-8(17)6(4-16)9(15)22(11,20)21/h2-3,6-7,9,16H,4-5H2,1H3,(H,18,19)/p-1/t6-,7+,9-,11+/m1/s1 XPRZVSWHOFCGHP-SZVQBCOZSA-M 50076683 CHEMBL6533::Sodium; (2S,3S,5R,6R)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 6 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076683&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931081 103969554 CHEMBL6533 ZINC03979561 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011532 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 1400 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011536 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na] InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1 RFMIKMMOLPNEDG-QVUDESDKSA-M 50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum Beta-lactamase TEM 60 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663400 104044614 CHEMBL1439 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011537 C[C@]1(\C=C\C#N)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C([O-])=O InChI=1S/C11H12N2O6S/c1-11(3-2-4-12)7(10(16)17)13-8(15)6(5-14)9(13)20(11,18)19/h2-3,6-7,9,14H,5H2,1H3,(H,16,17)/p-1/b3-2+/t6-,7+,9-,11+/m1/s1 NZNHTQCXWOAKDT-SURRTWTPSA-M 50076679 CHEMBL269471::Sodium; (2S,3S,5R,6R)-3-((E)-2-cyano-vinyl)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 74 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076679&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931078 103969550 CHEMBL269471 ZINC33967650 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011538 CO\N=C\[C@@]1(C)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H14N2O7S/c1-10(4-11-19-2)6(9(15)16)12-7(14)5(3-13)8(12)20(10,17)18/h4-6,8,13H,3H2,1-2H3,(H,15,16)/p-1/b11-4+/t5-,6+,8-,10+/m1/s1 FQSPFOVCHGZCIK-YOMQDVOZSA-M 50076682 CHEMBL6678::Sodium; (2S,3S,5R,6R)-6-hydroxymethyl-3-(methoxyimino-methyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 64 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076682&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931080 103969553 CHEMBL6678 ZINC25966233 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011539 C[C@]1(\C=C/C#N)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C([O-])=O InChI=1S/C11H12N2O6S/c1-11(3-2-4-12)7(10(16)17)13-8(15)6(5-14)9(13)20(11,18)19/h2-3,6-7,9,14H,5H2,1H3,(H,16,17)/p-1/b3-2-/t6-,7+,9-,11+/m1/s1 NZNHTQCXWOAKDT-QORJOZBASA-M 50076681 CHEMBL6469::Sodium; (2S,3S,5R,6R)-3-((Z)-2-cyano-vinyl)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 19 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076681&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931079 103969552 CHEMBL6469 ZINC33967649 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50011544 C[C@]1(\C=C\C#N)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H10N2O5S/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17/h2-3,7-8H,5H2,1H3,(H,14,15)/p-1/b3-2+/t7-,8+,10+/m1/s1 JYGFUXUBGZBBAC-RCRIAUEHSA-M 50076680 CHEMBL6461::Ro-48-1220::Sodium; (2S,3R,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::Sodium; (2S,3S,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 42 ChEMBL 10.1016/s0960-894x(99)00107-9 10.7270/Q2PK0FBJ 10230627 Bitha, P; Li, Z; Francisco, GD; Yang, Y; Petersen, PJ; Lenoy, E; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22873173 103969551 CHEMBL6461 ZINC13604487 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031062 COC(=O)c1cnnn1C[C@@]1(C)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C13H15N3O7S/c1-13(5-16-6(4-14-15-16)12(20)23-2)10(11(18)19)9-7(17)3-8(9)24(13,21)22/h4,8-10H,3,5H2,1-2H3,(H,18,19)/p-1/t8?,9?,10-,13-/m0/s1 MWZMTCLBFOZXKV-GPCLJDEGSA-M 50021960 CHEMBL286323::Sodium; 3-(5-methoxycarbonyl-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 300 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021960&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928982 103932649 CHEMBL286323 ZINC29230866 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031064 CCOC(=O)c1cn(C[C@@]2(C)[C@@H](C3C(CC3=O)S2(=O)=O)C([O-])=O)nn1 InChI=1S/C14H17N3O7S/c1-3-24-13(21)7-5-17(16-15-7)6-14(2)11(12(19)20)10-8(18)4-9(10)25(14,22)23/h5,9-11H,3-4,6H2,1-2H3,(H,19,20)/p-1/t9?,10?,11-,14-/m0/s1 SUJDDWICKSOENB-PTNRUYDSSA-M 50021958 CHEMBL33950::Sodium; 3-(4-ethoxycarbonyl-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 54 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021958&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928981 103932647 CHEMBL33950 ZINC29238311 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031066 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 21000 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031068 COC(=O)c1nnn(C[C@@]2(C)[C@@H](C3C(CC3=O)S2(=O)=O)C([O-])=O)c1C(=O)OC InChI=1S/C15H17N3O9S/c1-15(9(12(20)21)8-6(19)4-7(8)28(15,24)25)5-18-11(14(23)27-3)10(16-17-18)13(22)26-2/h7-9H,4-5H2,1-3H3,(H,20,21)/p-1/t7?,8?,9-,15-/m0/s1 CJHINZCBCHTSOE-PRFJFZKWSA-M 50021957 CHEMBL284273::Sodium; 3-(4,5-bis-methoxycarbonyl-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 300 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021957&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928980 103932646 CHEMBL284273 ZINC29240650 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031071 C[C@]1(Cn2nncc2C([O-])=O)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C12H13N3O7S/c1-12(4-15-5(10(17)18)3-13-14-15)9(11(19)20)8-6(16)2-7(8)23(12,21)22/h3,7-9H,2,4H2,1H3,(H,17,18)(H,19,20)/p-2/t7?,8?,9-,12-/m0/s1 DZCHPZBOQLTTII-RMVUORRVSA-L 50021962 CHEMBL288566::dipotassium 1-{[(3R,4S)-4-carboxylato-3-methyl-2,2-dioxido-6-oxo-2-thiabicyclo[3.2.0]hept-3-yl]methyl}-1H-1,2,3-triazole-5-carboxylate Beta-lactamase TEM 1700 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021962&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928984 103932651 CHEMBL288566 ZINC29249170 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031072 C[C@]1(Cn2cc(nn2)C([O-])=O)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C12H13N3O7S/c1-12(4-15-3-5(10(17)18)13-14-15)9(11(19)20)8-6(16)2-7(8)23(12,21)22/h3,7-9H,2,4H2,1H3,(H,17,18)(H,19,20)/p-2/t7?,8?,9-,12-/m0/s1 GIFHLGGIPIAVNV-RMVUORRVSA-L 50021961 CHEMBL286829::dipotassium 1-{[(3R,4S)-4-carboxylato-3-methyl-2,2-dioxido-6-oxo-2-thiabicyclo[3.2.0]hept-3-yl]methyl}-1H-1,2,3-triazole-4-carboxylate Beta-lactamase TEM 600 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021961&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928983 103932650 CHEMBL286829 ZINC29241255 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031073 C[C@]1(Cn2cc(N)nn2)[C@@H](C2C(CC2=O)S1(=O)=O)C(O)=O InChI=1S/C11H14N4O5S/c1-11(4-15-3-7(12)13-14-15)9(10(17)18)8-5(16)2-6(8)21(11,19)20/h3,6,8-9H,2,4,12H2,1H3,(H,17,18)/t6?,8?,9-,11-/m0/s1 LDDMNOXUAMVHDZ-WMUAKXSPSA-N 50021955 3-(4-Amino-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylic acid::CHEMBL35480 Beta-lactamase TEM 700 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021955&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44282937 103932644 CHEMBL35480 ZINC29247054 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031074 COC(=O)c1cn(C[C@@]2(C)[C@@H](C3C(CC3=O)S2(=O)=O)C([O-])=O)nn1 InChI=1S/C13H15N3O7S/c1-13(5-16-4-6(14-15-16)12(20)23-2)10(11(18)19)9-7(17)3-8(9)24(13,21)22/h4,8-10H,3,5H2,1-2H3,(H,18,19)/p-1/t8?,9?,10-,13-/m0/s1 DRBXTSRICBKWDR-GPCLJDEGSA-M 50021963 CHEMBL33711::Sodium; 3-(4-methoxycarbonyl-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 49 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021963&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928985 103932652 CHEMBL33711 ZINC29230894 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031075 C[C@]1(Cn2ccnn2)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C11H13N3O5S/c1-11(5-14-3-2-12-13-14)9(10(16)17)8-6(15)4-7(8)20(11,18)19/h2-3,7-9H,4-5H2,1H3,(H,16,17)/p-1/t7?,8?,9-,11-/m0/s1 AVPVJZPIBNHZQN-CAUGXEKISA-M 50021956 CHEMBL285387::Sodium; 3-methyl-2,2,6-trioxo-3-[1,2,3]triazol-1-ylmethyl-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 690 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021956&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928979 103932645 CHEMBL285387 ZINC29234607 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031076 C[C@]1(Cn2cc(nn2)[Si](C)(C)C)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C14H21N3O5SSi/c1-14(7-17-6-10(15-16-17)24(2,3)4)12(13(19)20)11-8(18)5-9(11)23(14,21)22/h6,9,11-12H,5,7H2,1-4H3,(H,19,20)/p-1/t9?,11?,12-,14-/m0/s1 NNBVKIUYCIQKNA-UOTDJEAJSA-M 50021964 CHEMBL284828::Sodium; 3-methyl-2,2,6-trioxo-3-(4-trimethylsilanyl-[1,2,3]triazol-1-ylmethyl)-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 510 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021964&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928986 103932653 CHEMBL284828 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031077 CCOC(=O)c1cnnn1C[C@@]1(C)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C14H17N3O7S/c1-3-24-13(21)7-5-15-16-17(7)6-14(2)11(12(19)20)10-8(18)4-9(10)25(14,22)23/h5,9-11H,3-4,6H2,1-2H3,(H,19,20)/p-1/t9?,10?,11-,14-/m0/s1 AGRPURZKBDMSSM-PTNRUYDSSA-M 50021965 CHEMBL35418::Sodium; 3-(5-ethoxycarbonyl-[1,2,3]triazol-1-ylmethyl)-3-methyl-2,2,6-trioxo-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 340 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021965&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928987 103932654 CHEMBL35418 ZINC29238280 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031079 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 320000 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034424 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 800 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034425 Cc1ccc(cc1N1CCC1=O)C(O)=O InChI=1S/C11H11NO3/c1-7-2-3-8(11(14)15)6-9(7)12-5-4-10(12)13/h2-3,6H,4-5H2,1H3,(H,14,15) XLQAIEGAEHIXRJ-UHFFFAOYSA-N 50022785 4-Methyl-3-(2-oxo-azetidin-1-yl)-benzoic acid::CHEMBL124880 Beta-lactamase TEM 10000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022785&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13400034 103933342 CHEMBL124880 ZINC27208282 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034426 Cc1ccc(cc1N1CC(F)C1=O)C(O)=O InChI=1S/C11H10FNO3/c1-6-2-3-7(11(15)16)4-9(6)13-5-8(12)10(13)14/h2-4,8H,5H2,1H3,(H,15,16) WKRYJOUCCNCEFZ-UHFFFAOYSA-N 50022786 3-(3-Fluoro-2-oxo-azetidin-1-yl)-4-methyl-benzoic acid::CHEMBL125999 Beta-lactamase TEM 20000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022786&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13994440 103933343 CHEMBL125999 ZINC27209688 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034427 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1 JGSARLDLIJGVTE-MBNYWOFBSA-N 50022787 (+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G)::(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion (Penicillin G)::3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G)::BICILLIN::PENICILLIN G::PENICILLIN G PROCAINE::PENICILLIN-2::PERMAPEN::PFIZERPEN::PFIZERPEN-AS::benzylpenicillin Beta-lactamase TEM 20000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022787&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search PNN 1FXV,3HUO,1UOB,5KMW,3KP2,1UOF,1GM7 5904 103933344 18208 DB01053 4796 C00395 ZINC03871701 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034428 Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C(O)=O)-c1ccccc1Cl InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1 LQOLIRLGBULYKD-JKIFEVAISA-N 50022788 (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL891::CLOXAPEN::TEGOPEN::cloxacillin Beta-lactamase TEM 13000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022788&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search CXN 6098 103933345 49566 CHEMBL891 DB01147 C00395 ZINC03875417 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034429 OC(=O)c1ccc2C(F)CC3CC(=O)N3c2c1 InChI=1S/C12H10FNO3/c13-9-4-7-5-11(15)14(7)10-3-6(12(16)17)1-2-8(9)10/h1-3,7,9H,4-5H2,(H,16,17) VFHYJAZQZSRGAA-UHFFFAOYSA-N 50022789 4-Fluoro-1-oxo-2,2a,3,4-tetrahydro-1H-azeto[1,2-a]quinoline-7-carboxylic acid::CHEMBL125658 Beta-lactamase TEM 39000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022789&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13877491 103933346 CHEMBL125658 ZINC27208458 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034430 OC(=O)c1ccc2CCC3CC(=O)N3c2c1 InChI=1S/C12H11NO3/c14-11-6-9-4-3-7-1-2-8(12(15)16)5-10(7)13(9)11/h1-2,5,9H,3-4,6H2,(H,15,16) YQSQCTCUOCDPIC-UHFFFAOYSA-N 50022790 1-Oxo-2,2a,3,4-tetrahydro-1H-azeto[1,2-a]quinoline-7-carboxylic acid::CHEMBL333494 Beta-lactamase TEM 20000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022790&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13877489 103933347 CHEMBL333494 ZINC27211754 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034431 Cc1ccc(cc1N1CC(Br)(Br)C1=O)C(O)=O InChI=1S/C11H9Br2NO3/c1-6-2-3-7(9(15)16)4-8(6)14-5-11(12,13)10(14)17/h2-4H,5H2,1H3,(H,15,16) YMQXBQIBJGRFFO-UHFFFAOYSA-N 50022791 3-(3,3-Dibromo-2-oxo-azetidin-1-yl)-4-methyl-benzoic acid::CHEMBL123270 Beta-lactamase TEM 160000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022791&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13994439 103933348 CHEMBL123270 ZINC27204794 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034432 Cc1ccc(cc1N1CC(F)(F)C1=O)C(O)=O InChI=1S/C11H9F2NO3/c1-6-2-3-7(9(15)16)4-8(6)14-5-11(12,13)10(14)17/h2-4H,5H2,1H3,(H,15,16) SHOPFZUVLSWSLQ-UHFFFAOYSA-N 50022793 3-(3,3-Difluoro-2-oxo-azetidin-1-yl)-4-methyl-benzoic acid::CHEMBL338243 Beta-lactamase TEM 83000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022793&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13994437 103933350 CHEMBL338243 ZINC27209515 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034433 OC(=O)c1ccc2C(Cl)CC3CC(=O)N3c2c1 InChI=1S/C12H10ClNO3/c13-9-4-7-5-11(15)14(7)10-3-6(12(16)17)1-2-8(9)10/h1-3,7,9H,4-5H2,(H,16,17) NILNONPRPJNISS-UHFFFAOYSA-N 50022792 4-Chloro-1-oxo-2,2a,3,4-tetrahydro-1H-azeto[1,2-a]quinoline-7-carboxylic acid::CHEMBL122500 Beta-lactamase TEM 50000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022792&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13877490 103933349 CHEMBL122500 ZINC27203930 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034434 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 800 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034435 Cc1ccc(cc1N1CC(F)(Br)C1=O)C(O)=O InChI=1S/C11H9BrFNO3/c1-6-2-3-7(9(15)16)4-8(6)14-5-11(12,13)10(14)17/h2-4H,5H2,1H3,(H,15,16) ZMEYGWYAPROCLD-UHFFFAOYSA-N 50022795 3-(3-Bromo-3-fluoro-2-oxo-azetidin-1-yl)-4-methyl-benzoic acid::CHEMBL125652 Beta-lactamase TEM 60000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022795&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13994436 103933352 CHEMBL125652 ZINC27208296 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50034436 Cc1ccc(cc1N1CC(Br)C1=O)C(O)=O InChI=1S/C11H10BrNO3/c1-6-2-3-7(11(15)16)4-9(6)13-5-8(12)10(13)14/h2-4,8H,5H2,1H3,(H,15,16) YMHLNIJMMQYHGA-UHFFFAOYSA-N 50022794 3-(3-Bromo-2-oxo-azetidin-1-yl)-4-methyl-benzoic acid::CHEMBL338512 Beta-lactamase TEM 40000 ChEMBL 10.1021/jm00397a018 10.7270/Q21R6PHS 3257523 Joyeau, R; Molines, H; Labia, R; Wakselman, M CNRS-CERCOA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022794&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13994438 103933351 CHEMBL338512 ZINC27203942 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50043381 C[C@]1(\C=C\C#N)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H10N2O5S/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17/h2-3,7-8H,5H2,1H3,(H,14,15)/p-1/b3-2+/t7-,8+,10+/m1/s1 JYGFUXUBGZBBAC-RCRIAUEHSA-M 50076680 CHEMBL6461::Ro-48-1220::Sodium; (2S,3R,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::Sodium; (2S,3S,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 1070 ChEMBL 10.1021/jm9601967 10.7270/Q2ZK5H99 8809160 Richter, HG; Angehrn, P; Hubschwerlen, C; Kania, M; Page, MG; Specklin, JL; Winkler, FK F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22873173 103969551 CHEMBL6461 ZINC13604487 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50043384 C[C@]1(\C=C\C#N)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H10N2O5S/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17/h2-3,7-8H,5H2,1H3,(H,14,15)/p-1/b3-2+/t7-,8+,10+/m1/s1 JYGFUXUBGZBBAC-RCRIAUEHSA-M 50076680 CHEMBL6461::Ro-48-1220::Sodium; (2S,3R,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::Sodium; (2S,3S,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 980 ChEMBL 10.1021/jm9601967 10.7270/Q2ZK5H99 8809160 Richter, HG; Angehrn, P; Hubschwerlen, C; Kania, M; Page, MG; Specklin, JL; Winkler, FK F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22873173 103969551 CHEMBL6461 ZINC13604487 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041438 CC(=O)OCC1=C(N2[C@@H](\C(=C\Br)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C11H10BrNO7S/c1-5(14)20-3-6-4-21(18,19)10-7(2-12)9(15)13(10)8(6)11(16)17/h2,10H,3-4H2,1H3,(H,16,17)/p-1/b7-2+/t10-/m1/s1 IWSSJMHCOIGHBY-CYZOPGGISA-M 50033684 CHEMBL269657::Sodium; (R)-3-acetoxymethyl-7-[1-bromo-meth-(E)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033684&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929130 103941944 CHEMBL269657 ZINC13740799 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041439 CC(=O)OCC1=C(N2[C@@H](C(=C(Cl)Cl)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C11H9Cl2NO7S/c1-4(15)21-2-5-3-22(19,20)10-6(8(12)13)9(16)14(10)7(5)11(17)18/h10H,2-3H2,1H3,(H,17,18)/p-1/t10-/m1/s1 ZLZSKFBDQKKTSB-SNVBAGLBSA-M 50033689 CHEMBL8111::Sodium; (R)-3-acetoxymethyl-7-dichloromethylene-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 8300 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033689&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929133 103941948 CHEMBL8111 ZINC13740796 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041441 CON(C)C(=O)\C=C1/[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O InChI=1S/C14H16N2O7S/c1-7(17)23-5-8-6-24-13-9(4-10(18)15(2)22-3)12(19)16(13)11(8)14(20)21/h4,13H,5-6H2,1-3H3,(H,20,21)/p-1/b9-4-/t13-/m1/s1 FCRFEZIEAJOTEF-VVOKDJNJSA-M 50033683 CHEMBL8353::Sodium; (R)-3-acetoxymethyl-7-[1-(methoxy-methyl-carbamoyl)-meth-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033683&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929129 103941943 CHEMBL8353 ZINC13740792 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041442 CC(=O)OCC1=C(N2[C@@H](C(=C(Br)Br)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C11H9Br2NO7S/c1-4(15)21-2-5-3-22(19,20)10-6(8(12)13)9(16)14(10)7(5)11(17)18/h10H,2-3H2,1H3,(H,17,18)/p-1/t10-/m1/s1 PXOKVALSRAGFAH-SNVBAGLBSA-M 50033686 CHEMBL7995::Sodium; (R)-3-acetoxymethyl-7-dibromomethylene-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033686&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929131 103941946 CHEMBL7995 ZINC13740795 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041445 CC(=O)OCC1=C(N2[C@H](SC1)C(=C(Cl)Cl)C2=O)C([O-])=O InChI=1S/C11H9Cl2NO5S/c1-4(15)19-2-5-3-20-10-6(8(12)13)9(16)14(10)7(5)11(17)18/h10H,2-3H2,1H3,(H,17,18)/p-1/t10-/m1/s1 SPOYTMWGOMJDIX-SNVBAGLBSA-M 50033687 CHEMBL8259::Sodium; (R)-3-acetoxymethyl-7-dichloromethylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033687&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929132 103941947 CHEMBL8259 ZINC13740786 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041450 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C(C)(C)C)C2=O)C([O-])=O InChI=1S/C15H19NO5S/c1-8(17)21-6-9-7-22-13-10(5-15(2,3)4)12(18)16(13)11(9)14(19)20/h5,13H,6-7H2,1-4H3,(H,19,20)/p-1/b10-5-/t13-/m1/s1 GVESJWVLYJUUMT-OMPYUXFZSA-M 50033695 CHEMBL8343::Sodium; (R)-3-acetoxymethyl-7-[2,2-dimethyl-prop-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033695&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929139 103941954 CHEMBL8343 ZINC13740794 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041453 CC(=O)OCC1=C(N2[C@@H](\C(=C\c3ccccc3)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C17H15NO7S/c1-10(19)25-8-12-9-26(23,24)16-13(7-11-5-3-2-4-6-11)15(20)18(16)14(12)17(21)22/h2-7,16H,8-9H2,1H3,(H,21,22)/p-1/b13-7+/t16-/m1/s1 YOCVKSISBJBEES-ROCHPLJESA-M 50033699 CHEMBL8511::Sodium; (R)-3-acetoxymethyl-5,5,8-trioxo-7-[1-phenyl-meth-(E)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033699&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929143 103941958 CHEMBL8511 ZINC13740797 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041454 CC(=O)OCC1=C(N2[C@@H](\C(=C/c3ccccc3)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C17H15NO7S/c1-10(19)25-8-12-9-26(23,24)16-13(7-11-5-3-2-4-6-11)15(20)18(16)14(12)17(21)22/h2-7,16H,8-9H2,1H3,(H,21,22)/p-1/b13-7-/t16-/m1/s1 YOCVKSISBJBEES-VXXVJXPCSA-M 50033693 CHEMBL268860::Sodium; (R)-3-acetoxymethyl-5,5,8-trioxo-7-[1-phenyl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033693&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929137 103941952 CHEMBL268860 ZINC03826256 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041463 CC(=O)OCC1=C(N2[C@H](SC1)C(=CC(C)=O)C2=O)C([O-])=O InChI=1S/C13H13NO6S/c1-6(15)3-9-11(17)14-10(13(18)19)8(4-20-7(2)16)5-21-12(9)14/h3,12H,4-5H2,1-2H3,(H,18,19)/p-1/t12-/m1/s1 ZSPQUKSEVIUMSR-GFCCVEGCSA-M 50033697 CHEMBL8571::Sodium; (R)-3-acetoxymethyl-8-oxo-7-[2-oxo-prop-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033697&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929141 103941956 CHEMBL8571 ZINC13740790 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041464 CC(=O)OCC1=C(N2[C@@H](C(=C=CC(C)(C)C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C16H19NO7S/c1-9(18)24-7-10-8-25(22,23)14-11(5-6-16(2,3)4)13(19)17(14)12(10)15(20)21/h6,14H,7-8H2,1-4H3,(H,20,21)/p-1/t5?,14-/m1/s1 HFICAXNAWUOCGS-XJQCMFKWSA-M 50033690 CHEMBL416327::Sodium; (R)-3-acetoxymethyl-7-(3,3-dimethyl-but-1-enylidene)-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033690&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929134 103941949 CHEMBL416327 ZINC03918658 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041465 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C=O)C2=O)C([O-])=O InChI=1S/C12H11NO6S/c1-6(15)19-4-7-5-20-11-8(2-3-14)10(16)13(11)9(7)12(17)18/h2-3,11H,4-5H2,1H3,(H,17,18)/p-1/b8-2-/t11-/m1/s1 FJJSTWQDAAUCMC-GPWUBDCCSA-M 50033700 CHEMBL8307::Sodium; (R)-3-acetoxymethyl-8-oxo-7-[2-oxo-eth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033700&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929144 103941959 CHEMBL8307 ZINC13740791 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041466 CC(=O)OCC1=C(N2[C@@H](\C(=C/C(C)(C)C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C15H19NO7S/c1-8(17)23-6-9-7-24(21,22)13-10(5-15(2,3)4)12(18)16(13)11(9)14(19)20/h5,13H,6-7H2,1-4H3,(H,19,20)/p-1/b10-5-/t13-/m1/s1 GGHHCDXUXTXKBM-OMPYUXFZSA-M 50033694 CHEMBL266689::Sodium; (R)-3-acetoxymethyl-7-[2,2-dimethyl-prop-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033694&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929138 103941953 CHEMBL266689 ZINC13740800 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041470 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C(=O)OC(C)(C)C)C2=O)C([O-])=O InChI=1S/C16H19NO7S/c1-8(18)23-6-9-7-25-14-10(5-11(19)24-16(2,3)4)13(20)17(14)12(9)15(21)22/h5,14H,6-7H2,1-4H3,(H,21,22)/p-1/b10-5-/t14-/m1/s1 KKHROROKABOCRS-XTXQVDMPSA-M 50033696 CHEMBL269308::Sodium; (R)-3-acetoxymethyl-7-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033696&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929140 103941955 CHEMBL269308 ZINC03826255 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041472 CC(=O)OCC1=C(N2[C@@H](\C(=C/CO)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C12H13NO8S/c1-6(15)21-4-7-5-22(19,20)11-8(2-3-14)10(16)13(11)9(7)12(17)18/h2,11,14H,3-5H2,1H3,(H,17,18)/p-1/b8-2-/t11-/m1/s1 BIUVASJLHVNNEP-GPWUBDCCSA-M 50033698 CHEMBL273744::Sodium; (R)-3-acetoxymethyl-7-[2-hydroxy-eth-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033698&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929142 103941957 CHEMBL273744 ZINC13740798 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041477 CC(=O)OCC1=C(N2[C@@H](\C(=C/C(=O)OC(C)(C)C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C16H19NO9S/c1-8(18)25-6-9-7-27(23,24)14-10(5-11(19)26-16(2,3)4)13(20)17(14)12(9)15(21)22/h5,14H,6-7H2,1-4H3,(H,21,22)/p-1/b10-5-/t14-/m1/s1 LQVZDTYWLLBGHZ-XTXQVDMPSA-M 50033680 CHEMBL268919::Sodium; (R)-3-acetoxymethyl-7-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 5 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929126 103941940 CHEMBL268919 ZINC03949252 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041479 CC(=O)OCC1=C(N2[C@@H](\C(=C/c3ccccn3)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C16H14N2O7S/c1-9(19)25-7-10-8-26(23,24)15-12(6-11-4-2-3-5-17-11)14(20)18(15)13(10)16(21)22/h2-6,15H,7-8H2,1H3,(H,21,22)/p-1/b12-6-/t15-/m1/s1 ITFVZKLBKASFHP-NYXMJBRJSA-M 50033701 CHEMBL268632::Sodium; (R)-3-acetoxymethyl-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 800 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033701&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929145 103941960 CHEMBL268632 ZINC03826254 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041495 CC(=O)OCC1=C(N2[C@H](SC1)C(=C(Br)Br)C2=O)C([O-])=O InChI=1S/C11H9Br2NO5S/c1-4(15)19-2-5-3-20-10-6(8(12)13)9(16)14(10)7(5)11(17)18/h10H,2-3H2,1H3,(H,17,18)/p-1/t10-/m1/s1 IAYUXXWVOBMOKN-SNVBAGLBSA-M 50033691 CHEMBL7597::Sodium; (R)-3-acetoxymethyl-7-dibromomethylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033691&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929135 103941950 CHEMBL7597 ZINC13740785 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041496 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/c1ccccc1)C2=O)C([O-])=O InChI=1S/C17H15NO5S/c1-10(19)23-8-12-9-24-16-13(7-11-5-3-2-4-6-11)15(20)18(16)14(12)17(21)22/h2-7,16H,8-9H2,1H3,(H,21,22)/p-1/b13-7-/t16-/m1/s1 VGEKZJBJPIFSJW-VXXVJXPCSA-M 50033681 CHEMBL268631::Sodium; (R)-3-acetoxymethyl-8-oxo-7-[1-phenyl-meth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033681&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929127 103941941 CHEMBL268631 ZINC13740787 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041497 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/c1ccccn1)C2=O)C([O-])=O InChI=1S/C16H14N2O5S/c1-9(19)23-7-10-8-24-15-12(6-11-4-2-3-5-17-11)14(20)18(15)13(10)16(21)22/h2-6,15H,7-8H2,1H3,(H,21,22)/p-1/b12-6-/t15-/m1/s1 CQNPZZNQXQNFCS-NYXMJBRJSA-M 50033682 CHEMBL267745::Sodium; (R)-3-acetoxymethyl-8-oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >2000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033682&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929128 103941942 CHEMBL267745 ZINC13740788 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041498 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C([O-])=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/p-1/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-M 50033685 CHEMBL8290::Sodium; (2R,5R)-3-[2-hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 60 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033685&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 16204478 103941945 CHEMBL8290 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041501 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na] InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1 RFMIKMMOLPNEDG-QVUDESDKSA-M 50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum Beta-lactamase TEM 25 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663400 104044614 CHEMBL1439 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50041447 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C\Br)C2=O)C([O-])=O InChI=1S/C11H10BrNO5S/c1-5(14)18-3-6-4-19-10-7(2-12)9(15)13(10)8(6)11(16)17/h2,10H,3-4H2,1H3,(H,16,17)/p-1/b7-2+/t10-/m1/s1 LEADWAGQWAFRFE-CYZOPGGISA-M 50033692 CHEMBL8371::Sodium; (R)-3-acetoxymethyl-7-[1-bromo-meth-(E)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1021/jm00006a022 10.7270/Q29S1Q29 7699694 Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929136 103941951 CHEMBL8371 ZINC13740793 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178486 COC(=O)\C=C\CC1[C@H]2N([C@@H](C(O)=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C13H17NO7S/c1-13(2)9(12(17)18)14-10(16)7(11(14)22(13,19)20)5-4-6-8(15)21-3/h4,6-7,9,11H,5H2,1-3H3,(H,17,18)/b6-4+/t7?,9-,11-/m0/s1 WHIIGHHQWOXKEP-KWLOKCHISA-N 50099186 (2S,5S)-6-((E)-3-Methoxycarbonyl-allyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6221 Beta-lactamase TEM 2800 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099186&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264125 103996104 CHEMBL6221 ZINC25962797 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178487 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(nn3)-c3ccc(N)cc3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C17H19N5O5S/c1-17(2)13(16(24)25)22-14(23)12(15(22)28(17,26)27)7-10-8-21(20-19-10)11-5-3-9(18)4-6-11/h3-6,8,12-13,15H,7,18H2,1-2H3,(H,24,25)/t12-,13+,15-/m1/s1 QEYUTORLTFVDOI-VNHYZAJKSA-N 50099184 (2S,5R,6R)-6-[1-(4-Amino-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL267863 Beta-lactamase TEM 600 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099184&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10386556 103996102 CHEMBL267863 ZINC25963309 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178489 COC(=O)\C=C\CC1[C@@H]2N([C@@H](C(O)=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C13H17NO7S/c1-13(2)9(12(17)18)14-10(16)7(11(14)22(13,19)20)5-4-6-8(15)21-3/h4,6-7,9,11H,5H2,1-3H3,(H,17,18)/b6-4+/t7?,9-,11+/m0/s1 WHIIGHHQWOXKEP-ASQRRCTNSA-N 50099189 (2S,5R)-6-((E)-3-Methoxycarbonyl-allyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6309 Beta-lactamase TEM 8600 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099189&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264221 103996107 CHEMBL6309 ZINC25963538 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178492 CC(=O)CC=CC1[C@H]2N([C@@H](C(O)=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C13H17NO6S/c1-7(15)5-4-6-8-10(16)14-9(12(17)18)13(2,3)21(19,20)11(8)14/h4,6,8-9,11H,5H2,1-3H3,(H,17,18)/t8?,9-,11-/m0/s1 KKSAGQLHTXTMBB-PCFYAGROSA-N 50099188 (2S,5S)-3,3-Dimethyl-4,4,7-trioxo-6-((E)-4-oxo-pent-2-enyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6311 Beta-lactamase TEM 6500 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099188&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931643 103996106 CHEMBL6311 ZINC25963563 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178498 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(nn3)-c3ccc(F)cc3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C17H17FN4O5S/c1-17(2)13(16(24)25)22-14(23)12(15(22)28(17,26)27)7-10-8-21(20-19-10)11-5-3-9(18)4-6-11/h3-6,8,12-13,15H,7H2,1-2H3,(H,24,25)/t12-,13+,15-/m1/s1 QSGHUBRFRCSOPB-VNHYZAJKSA-N 50099193 (2S,5R,6R)-6-[1-(4-Fluoro-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6292 Beta-lactamase TEM 1600 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099193&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264223 103996111 CHEMBL6292 ZINC25963304 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178502 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 1400 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178503 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 60 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178508 CON(C)C(=O)\C=C\CC1[C@@H]2N([C@@H](C(O)=O)C(C)(C)S2=O)C1=O InChI=1S/C14H20N2O6S/c1-14(2)10(13(19)20)16-11(18)8(12(16)23(14)21)6-5-7-9(17)15(3)22-4/h5,7-8,10,12H,6H2,1-4H3,(H,19,20)/b7-5+/t8?,10-,12+,23?/m0/s1 NODZXNWCPAUXPG-IDLZWDITSA-N 50099187 (2S,5R)-6-[(E)-3-(Methoxy-methyl-carbamoyl)-allyl]-3,3-dimethyl-4,7-dioxo-4lambda*4*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL267627 Beta-lactamase TEM 12000 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099187&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264287 103996105 CHEMBL267627 ZINC25963277 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178510 CC(=O)CC=CC1[C@@H]2N([C@@H](C(O)=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C13H17NO6S/c1-7(15)5-4-6-8-10(16)14-9(12(17)18)13(2,3)21(19,20)11(8)14/h4,6,8-9,11H,5H2,1-3H3,(H,17,18)/t8?,9-,11+/m0/s1 KKSAGQLHTXTMBB-CAWIPBJDSA-N 50099195 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-6-((E)-4-oxo-pent-2-enyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6301 Beta-lactamase TEM 8400 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099195&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931644 103996113 CHEMBL6301 ZINC25963529 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178511 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(CC4CCCN4)nn3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C16H23N5O5S/c1-16(2)12(15(23)24)21-13(22)11(14(21)27(16,25)26)6-10-8-20(19-18-10)7-9-4-3-5-17-9/h8-9,11-12,14,17H,3-7H2,1-2H3,(H,23,24)/t9?,11-,12+,14-/m1/s1 ANCXGKPUGCZNAI-OOPHUOBASA-N 50099185 (2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-(1-pyrrolidin-2-ylmethyl-1H-[1,2,3]triazol-4-ylmethyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6261 Beta-lactamase TEM 7900 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099185&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264222 103996103 CHEMBL6261 ZINC25963137 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178517 CC1(C)[C@@H](N2[C@H](C(C\C=C\C#N)C2=O)S1(=O)=O)C(O)=O InChI=1S/C12H14N2O5S/c1-12(2)8(11(16)17)14-9(15)7(5-3-4-6-13)10(14)20(12,18)19/h3-4,7-8,10H,5H2,1-2H3,(H,16,17)/b4-3+/t7?,8-,10-/m0/s1 HXCNDHVLZREMRV-QYJMCNQRSA-N 50099191 (2S,5S)-6-((E)-3-Cyano-allyl)-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL267626 Beta-lactamase TEM 24000 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099191&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264226 103996109 CHEMBL267626 ZINC36079875 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178518 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(nn3)-c3ccccc3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C17H18N4O5S/c1-17(2)13(16(23)24)21-14(22)12(15(21)27(17,25)26)8-10-9-20(19-18-10)11-6-4-3-5-7-11/h3-7,9,12-13,15H,8H2,1-2H3,(H,23,24)/t12-,13+,15-/m1/s1 JLLMLHDLOMWYNZ-VNHYZAJKSA-N 50099192 (2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-(1-phenyl-1H-[1,2,3]triazol-4-ylmethyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6220 Beta-lactamase TEM 1000 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099192&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264225 103996110 CHEMBL6220 ZINC25962787 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178523 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(CC(N)Cc4ccc(O)cc4)nn3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C20H25N5O6S/c1-20(2)16(19(28)29)25-17(27)15(18(25)32(20,30)31)8-13-10-24(23-22-13)9-12(21)7-11-3-5-14(26)6-4-11/h3-6,10,12,15-16,18,26H,7-9,21H2,1-2H3,(H,28,29)/t12?,15-,16+,18-/m1/s1 NRHINWWLSKCJNI-NZHQHIMKSA-N 50099194 (2S,5R,6R)-6-{1-[2-Amino-3-(4-hydroxy-phenyl)-propyl]-1H-[1,2,3]triazol-4-ylmethyl}-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL263882 Beta-lactamase TEM 15000 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099194&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264224 103996112 CHEMBL263882 ZINC25963642 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178524 CC1(C)[C@@H](N2[C@@H](C(C\C=C\C=O)C2=O)S1(=O)=O)C(O)=O InChI=1S/C12H15NO6S/c1-12(2)8(11(16)17)13-9(15)7(5-3-4-6-14)10(13)20(12,18)19/h3-4,6-8,10H,5H2,1-2H3,(H,16,17)/b4-3+/t7?,8-,10+/m0/s1 APLLQHCDOOGSFW-OQAFJANISA-N 50099196 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-6-((E)-4-oxo-but-2-enyl)-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6286 Beta-lactamase TEM 12000 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099196&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44264288 103996114 CHEMBL6286 ZINC25963287 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50178527 CC1(C)[C@@H](N2[C@@H]([C@H](Cc3cn(nn3)-c3ccc(O)cc3)C2=O)S1(=O)=O)C(O)=O InChI=1S/C17H18N4O6S/c1-17(2)13(16(24)25)21-14(23)12(15(21)28(17,26)27)7-9-8-20(19-18-9)10-3-5-11(22)6-4-10/h3-6,8,12-13,15,22H,7H2,1-2H3,(H,24,25)/t12-,13+,15-/m1/s1 KPAZRDMJBFRIBA-VNHYZAJKSA-N 50099190 (2S,5R,6R)-6-[1-(4-Hydroxy-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL6281 Beta-lactamase TEM 700 ChEMBL 10.1016/s0960-894x(01)00148-2 10.7270/Q2W958G8 11327608 Sandanayaka, VP; Feigelson, GB; Prashad, AS; Yang, Y; Petersen, PJ Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099190&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10001379 103996108 CHEMBL6281 ZINC25963252 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257889 CC1(C)S[C@@H]2[C@H](S)C(=O)N2[C@H]1C(O)=O InChI=1S/C8H11NO3S2/c1-8(2)4(7(11)12)9-5(10)3(13)6(9)14-8/h3-4,6,13H,1-2H3,(H,11,12)/t3-,4+,6-/m1/s1 WOYLBXUCZPJYOV-ALEPSDHESA-N 50140665 (2S,5R,6R)-6-Mercapto-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL24351 Beta-lactamase TEM >1000000 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140665&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274998 104030225 CHEMBL24351 ZINC28758305 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257896 CC1(C)S[C@@H]2[C@@H](S)C(=O)N2[C@H]1C(O)=O InChI=1S/C8H11NO3S2/c1-8(2)4(7(11)12)9-5(10)3(13)6(9)14-8/h3-4,6,13H,1-2H3,(H,11,12)/t3-,4-,6+/m0/s1 WOYLBXUCZPJYOV-RVJQKOHUSA-N 50140670 (2S,5R,6S)-6-Mercapto-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL24275 Beta-lactamase TEM 988000.0 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140670&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274974 104030230 CHEMBL24275 ZINC28757367 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257897 CC1(C)[C@@H](N2[C@@H]([C@@H](CO)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO6S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)17(9,15)16/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5-,7+/m0/s1 ODGTYAIFNCCEHW-KZLJYQGOSA-N 50076672 (2S,5R,6S)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL24878::Sodium; (2S,5R,6S)-6-hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 14600 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076672&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 15535824 103969543 CHEMBL24878 ZINC28759437 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257898 CC1(C)S[C@@H]2[C@@H](CO)C(=O)N2[C@H]1C(O)=O InChI=1S/C9H13NO4S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)15-9/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5-,7+/m0/s1 DJIMYYWAZIOWRD-KZLJYQGOSA-N 50140671 (2S,5R,6S)-6-Hydroxymethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::Beta-lactam compound, 1::CHEMBL277857 Beta-lactamase TEM 275000 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140671&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10443886 104030231 CHEMBL277857 ZINC28102870 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257902 CC1(C)S[C@@H]2[C@H](CS)C(=O)N2[C@H]1C(O)=O InChI=1S/C9H13NO3S2/c1-9(2)5(8(12)13)10-6(11)4(3-14)7(10)15-9/h4-5,7,14H,3H2,1-2H3,(H,12,13)/t4-,5+,7-/m1/s1 RHBQBGRVEOOJQL-JCGDXUMPSA-N 50140673 (2S,5R,6S)-6-Mercaptomethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL25644 Beta-lactamase TEM 601000 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140673&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10377312 104030233 CHEMBL25644 ZINC28758758 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257903 CC1(C)S[C@@H]2[C@@H](CS)C(=O)N2[C@H]1C(O)=O InChI=1S/C9H13NO3S2/c1-9(2)5(8(12)13)10-6(11)4(3-14)7(10)15-9/h4-5,7,14H,3H2,1-2H3,(H,12,13)/t4-,5-,7+/m0/s1 RHBQBGRVEOOJQL-KZLJYQGOSA-N 50140667 (2S,5R,6R)-6-Mercaptomethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL277225 Beta-lactamase TEM 648000.0 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140667&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44275089 104030227 CHEMBL277225 ZINC28758962 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257904 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na] InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1 RFMIKMMOLPNEDG-QVUDESDKSA-M 50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum Beta-lactamase TEM 122 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663400 104044614 CHEMBL1439 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257910 CC1(C)[C@@H](N2[C@@H]([C@H](CO)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO6S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)17(9,15)16/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5+,7-/m1/s1 ODGTYAIFNCCEHW-JCGDXUMPSA-N 50076678 (2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion::CHEMBL416561 Beta-lactamase TEM 650 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076678&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9852179 103969549 CHEMBL416561 ZINC03986689 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257891 CC1(C)[C@@H](N2[C@@H]([C@H](CS)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO5S2/c1-9(2)5(8(12)13)10-6(11)4(3-16)7(10)17(9,14)15/h4-5,7,16H,3H2,1-2H3,(H,12,13)/t4-,5+,7-/m1/s1 MQNFPHMTROMTJB-JCGDXUMPSA-N 50140666 (2S,5R,6S)-6-Mercaptomethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL25766 Beta-lactamase TEM 6800 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140666&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9948373 104030226 CHEMBL25766 ZINC28758109 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257929 CC1(C)[C@@H](N2[C@@H]([C@@H](S)C2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S2/c1-8(2)4(7(11)12)9-5(10)3(15)6(9)16(8,13)14/h3-4,6,15H,1-2H3,(H,11,12)/t3-,4-,6+/m0/s1 AFPLSUQTYBHSDG-RVJQKOHUSA-N 50140669 (2S,5R,6S)-6-Mercapto-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL26275 Beta-lactamase TEM 69200 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140669&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44274973 104030229 CHEMBL26275 ZINC28756593 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257930 CC1(C)S[C@@H]2[C@H](CO)C(=O)N2[C@H]1C(O)=O InChI=1S/C9H13NO4S/c1-9(2)5(8(13)14)10-6(12)4(3-11)7(10)15-9/h4-5,7,11H,3H2,1-2H3,(H,13,14)/t4-,5+,7-/m1/s1 DJIMYYWAZIOWRD-JCGDXUMPSA-N 50140672 (2S,5R,6R)-6-Hydroxymethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::Beta-lactam compound, 2::CHEMBL25613 Beta-lactamase TEM 752000.0 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140672&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 15535828 104030232 CHEMBL25613 ZINC28096014 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50257931 CC1(C)[C@@H](N2[C@@H]([C@@H](CS)C2=O)S1(=O)=O)C(O)=O InChI=1S/C9H13NO5S2/c1-9(2)5(8(12)13)10-6(11)4(3-16)7(10)17(9,14)15/h4-5,7,16H,3H2,1-2H3,(H,12,13)/t4-,5-,7+/m0/s1 MQNFPHMTROMTJB-KZLJYQGOSA-N 50140668 (2S,5R,6R)-6-Mercaptomethyl-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL24235 Beta-lactamase TEM 51700 ChEMBL 10.1016/j.bmcl.2003.12.037 10.7270/Q22Z14ZG 14980686 Buynak, JD; Chen, H; Vogeti, L; Gadhachanda, VR; Buchanan, CA; Palzkill, T; Shaw, RW; Spencer, J; Walsh, TR Southern Methodist University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140668&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44275088 104030228 CHEMBL24235 ZINC28758382 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50274555 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c3CCCc3sc2n1 InChI=1S/C15H11N3O3S2/c19-12-8(13-18(12)10(6-22-13)14(20)21)4-7-5-17-9-2-1-3-11(9)23-15(17)16-7/h4-6,13H,1-3H2,(H,20,21)/p-1/b8-4-/t13-/m1/s1 XFARUGBBAMTOCU-IBSXUBTNSA-M 50149467 (5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,1-b][1,3]thiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL122450::Sodium; (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate::sodium (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 1 ChEMBL 10.1021/jm049903j 10.7270/Q2MK6CCT 15214794 Tabei, K; Feng, X; Venkatesan, AM; Abe, T; Hideki, U; Mansour, TS; Siegel, MM Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149467&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91932994 104037578 CHEMBL122450 ZINC13580839 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50274560 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cnc2COCCn12 InChI=1S/C13H11N3O4S/c17-11-8(12-16(11)9(6-21-12)13(18)19)3-7-4-14-10-5-20-2-1-15(7)10/h3-4,6,12H,1-2,5H2,(H,18,19)/p-1/b8-3-/t12-/m1/s1 MTRYCRPKNWRHLE-CPWLGJMPSA-M 50149468 CHEMBL263746::Sodium; (R)-6-[1-(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-3-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 0.4 ChEMBL 10.1021/jm049903j 10.7270/Q2MK6CCT 15214794 Tabei, K; Feng, X; Venkatesan, AM; Abe, T; Hideki, U; Mansour, TS; Siegel, MM Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149468&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 71776534 104037579 CHEMBL263746 ZINC27196434 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50274567 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 100 ChEMBL 10.1021/jm049903j 10.7270/Q2MK6CCT 15214794 Tabei, K; Feng, X; Venkatesan, AM; Abe, T; Hideki, U; Mansour, TS; Siegel, MM Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50274571 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CCCn2n1 InChI=1S/C13H11N3O3S/c17-11-9(12-16(11)10(6-20-12)13(18)19)5-7-4-8-2-1-3-15(8)14-7/h4-6,12H,1-3H2,(H,18,19)/p-1/b9-5-/t12-/m1/s1 YJSNNWLWFJHTLH-DJTUGOFGSA-M 50149466 CHEMBL124416::Sodium; (R)-6-[1-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 1 ChEMBL 10.1021/jm049903j 10.7270/Q2MK6CCT 15214794 Tabei, K; Feng, X; Venkatesan, AM; Abe, T; Hideki, U; Mansour, TS; Siegel, MM Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149466&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91932993 104037577 CHEMBL124416 ZINC03819348 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289580 Cc1cccc2sc3nc(\C=C4/[C@H]5SC=C(N5C4=O)C(=O)O[Na])cn3c12 InChI=1S/C17H11N3O3S2.Na/c1-8-3-2-4-12-13(8)19-6-9(18-17(19)25-12)5-10-14(21)20-11(16(22)23)7-24-15(10)20;/h2-7,15H,1H3,(H,22,23);/q;+1/p-1/b10-5-;/t15-;/m1./s1 AAJNAPQWOPAZAE-BUROSNQKSA-M 50157687 (5R,6Z)-6-[(5-methylimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL222866 Beta-lactamase TEM 9 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157687&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23673074 104044610 CHEMBL222866 ZINC13586483 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289581 Cc1ccc2c(c1)sc1nc(\C=C3/[C@H]4SC=C(N4C3=O)C(=O)O[Na])cn21 InChI=1S/C17H11N3O3S2.Na/c1-8-2-3-11-13(4-8)25-17-18-9(6-19(11)17)5-10-14(21)20-12(16(22)23)7-24-15(10)20;/h2-7,15H,1H3,(H,22,23);/q;+1/p-1/b10-5-;/t15-;/m1./s1 FMUADCKWHCHFKD-BUROSNQKSA-M 50157688 (5R,6Z)-6-[(7-methylimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL222375 Beta-lactamase TEM 3 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157688&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23671165 104044611 CHEMBL222375 ZINC13586481 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289582 [Na]OC(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c(n1)sc1ccccc21 InChI=1S/C16H9N3O3S2.Na/c20-13-9(14-19(13)11(7-23-14)15(21)22)5-8-6-18-10-3-1-2-4-12(10)24-16(18)17-8;/h1-7,14H,(H,21,22);/q;+1/p-1/b9-5-;/t14-;/m1./s1 ICRJCLPRVQCDKT-MBZBDMRWSA-M 50157689 (5R,6Z)-6-(imidazo[2,1-b][1,3]benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL222758 Beta-lactamase TEM 10 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157689&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663813 104044612 CHEMBL222758 ZINC13586478 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289584 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(=O)O[Na] InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1 RFMIKMMOLPNEDG-QVUDESDKSA-M 50157692 CHEMBL1439::CL-307579::Sodium; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::TAZOBACTAM SODIUM::US9035062, TAZ::sodium (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::tazobactum Beta-lactamase TEM 100 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157692&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23663400 104044614 CHEMBL1439 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289585 [Na]OC(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c(n1)sc1cc(Cl)ccc21 InChI=1S/C16H8ClN3O3S2.Na/c17-7-1-2-10-12(3-7)25-16-18-8(5-19(10)16)4-9-13(21)20-11(15(22)23)6-24-14(9)20;/h1-6,14H,(H,22,23);/q;+1/p-1/b9-4-;/t14-;/m1./s1 SVACAECNLJKLOK-DEJRPRKJSA-M 50157693 (5R,6Z)-6-[(7-chloroimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL388778 Beta-lactamase TEM 6 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157693&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23682403 104044615 CHEMBL388778 ZINC13586480 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289586 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c3CCCc3sc2n1 InChI=1S/C15H11N3O3S2/c19-12-8(13-18(12)10(6-22-13)14(20)21)4-7-5-17-9-2-1-3-11(9)23-15(17)16-7/h4-6,13H,1-3H2,(H,20,21)/p-1/b8-4-/t13-/m1/s1 XFARUGBBAMTOCU-IBSXUBTNSA-M 50149467 (5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,1-b][1,3]thiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL122450::Sodium; (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate::sodium (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 1 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149467&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91932994 104037578 CHEMBL122450 ZINC13580839 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289600 Fc1ccc2c(c1)sc1nc(\C=C3/[C@H]4SC=C(N4C3=O)C(=O)O[Na])cn21 InChI=1S/C16H8FN3O3S2.Na/c17-7-1-2-10-12(3-7)25-16-18-8(5-19(10)16)4-9-13(21)20-11(15(22)23)6-24-14(9)20;/h1-6,14H,(H,22,23);/q;+1/p-1/b9-4-;/t14-;/m1./s1 HUPHEXATWXVGJT-DEJRPRKJSA-M 50157694 (5R,6Z)-6-[(7-fluoroimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium::CHEMBL222922 Beta-lactamase TEM 8 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157694&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23697537 104044616 CHEMBL222922 ZINC13586479 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50289602 COc1ccc2c(c1)sc1nc(\C=C3/[C@H]4SC=C(N4C3=O)C(=O)O[Na])cn21 InChI=1S/C17H11N3O4S2.Na/c1-24-9-2-3-11-13(5-9)26-17-18-8(6-19(11)17)4-10-14(21)20-12(16(22)23)7-25-15(10)20;/h2-7,15H,1H3,(H,22,23);/q;+1/p-1/b10-4-;/t15-;/m1./s1 NCXKBKBIIBQZIH-OWYPWVCMSA-M 50157691 (5R,6Z)-6-[(7-methoxyimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid sodium::CHEMBL375172 Beta-lactamase TEM 18 ChEMBL 10.1021/jm049680x 10.7270/Q2542N22 15588091 Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157691&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23669372 104044613 CHEMBL375172 ZINC13586482 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353730 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CNCCn2n1 InChI=1S/C13H12N4O3S/c18-11-9(12-17(11)10(6-21-12)13(19)20)4-7-3-8-5-14-1-2-16(8)15-7/h3-4,6,12,14H,1-2,5H2,(H,19,20)/p-1/b9-4-/t12-/m1/s1 NCGUZWKSZMMNCP-TWLAMCEISA-M 50191377 (5R),(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrazin-2-ylmethylene)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL379856 Beta-lactamase TEM 1 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191377&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936181 104074495 CHEMBL379856 ZINC34717636 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353735 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CN(Cc3cccnc3)CCc2s1 InChI=1S/C20H17N3O3S2/c24-18-15(19-23(18)16(11-27-19)20(25)26)7-14-6-13-10-22(5-3-17(13)28-14)9-12-2-1-4-21-8-12/h1-2,4,6-8,11,19H,3,5,9-10H2,(H,25,26)/p-1/b15-7-/t19-/m1/s1 JTXLOXAHJKZYOH-ZUYGLVRRSA-M 50191382 (5R,6Z)-7-oxo-6-{[5-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)]methylene}-7oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL211143 Beta-lactamase TEM 10 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191382&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936186 104074500 CHEMBL211143 ZINC34717635 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353736 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CSCCn2n1 InChI=1S/C13H11N3O3S2/c17-11-9(12-16(11)10(6-21-12)13(18)19)4-7-3-8-5-20-2-1-15(8)14-7/h3-4,6,12H,1-2,5H2,(H,18,19)/p-1/b9-4-/t12-/m1/s1 YRWWCWBDXGMNHI-TWLAMCEISA-M 50191379 (5R)(6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-thiazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL212760 Beta-lactamase TEM 1 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191379&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936183 104074497 CHEMBL212760 ZINC03819346 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353740 COc1ccc(CN2CCc3sc(\C=C4/[C@H]5SC=C(N5C4=O)C([O-])=O)cc3C2)cc1 InChI=1S/C22H20N2O4S2/c1-28-15-4-2-13(3-5-15)10-23-7-6-19-14(11-23)8-16(30-19)9-17-20(25)24-18(22(26)27)12-29-21(17)24/h2-5,8-9,12,21H,6-7,10-11H2,1H3,(H,26,27)/p-1/b17-9-/t21-/m1/s1 ZKKACLLQVNCVQU-VYBYYTRPSA-M 50191381 (5R,6Z)-6-{[5-(4-methoxybenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)]methylene}-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL378041 Beta-lactamase TEM 2 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191381&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936185 104074499 CHEMBL378041 ZINC34717632 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353743 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2COCCn2n1 InChI=1S/C13H11N3O4S/c17-11-9(12-16(11)10(6-21-12)13(18)19)4-7-3-8-5-20-2-1-15(8)14-7/h3-4,6,12H,1-2,5H2,(H,18,19)/p-1/b9-4-/t12-/m1/s1 DWYDARUUOLMALM-TWLAMCEISA-M 50191385 (5R,6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c]-[1,4]oxazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL377382 Beta-lactamase TEM 4 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191385&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936189 104074503 CHEMBL377382 ZINC03819351 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353749 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2OCCCn2n1 InChI=1S/C13H11N3O4S/c17-11-8(12-16(11)9(6-21-12)13(18)19)4-7-5-10-15(14-7)2-1-3-20-10/h4-6,12H,1-3H2,(H,18,19)/p-1/b8-4-/t12-/m1/s1 RRXLDJWFWBTXTP-HXUAIIEXSA-M 50191388 (5R)(6Z)-6-(6,7-5H-dihydropyrazolo[5,1-b]-oxazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL377001 Beta-lactamase TEM 6 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191388&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936192 104074506 CHEMBL377001 ZINC34717637 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353756 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CN(CCc2s1)c1cc2COCCc2s1 InChI=1S/C21H18N2O4S3/c24-19-14(20-23(19)15(10-28-20)21(25)26)7-13-5-11-8-22(3-1-16(11)29-13)18-6-12-9-27-4-2-17(12)30-18/h5-7,10,20H,1-4,8-9H2,(H,25,26)/p-1/b14-7-/t20-/m1/s1 KIBIIJXINDFXSV-BHBFUXRTSA-M 50191389 6-(6,7-dihydro-4H-thieno[3,2-c]pyran-2-ylmethylene)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylicacid sodium salt::CHEMBL380061 Beta-lactamase TEM 1 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191389&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936193 104074507 CHEMBL380061 ZINC34717630 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353761 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C/c1cn2CCOCc2n1 InChI=1S/C13H11N3O4S/c17-11-8(12-16(11)9(6-21-12)13(18)19)3-7-4-15-1-2-20-5-10(15)14-7/h3-4,6,12H,1-2,5H2,(H,18,19)/p-1/b8-3+/t12-/m1/s1 DMEYZPJEFHGESJ-STWLFGJUSA-M 50191378 CHEMBL212163::sodium (R,E)-6-((6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl)methylene)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 0.4 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191378&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936182 104074496 CHEMBL212163 ZINC34717629 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353762 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CS(=O)(=O)CCn2n1 InChI=1S/C13H11N3O5S2/c17-11-9(12-16(11)10(5-22-12)13(18)19)4-7-3-8-6-23(20,21)2-1-15(8)14-7/h3-5,12H,1-2,6H2,(H,18,19)/p-1/b9-4-/t12-/m1/s1 IBSSBUWAVGFIIX-TWLAMCEISA-M 50191390 (5R),(6Z)-6-(5,5-dioxo-4,5,6,7-tetrahydro-5'6-pyrazolo[5,1-c][1,4]thiazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL378119 Beta-lactamase TEM 1 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191390&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936194 104074508 CHEMBL378119 ZINC34717628 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353769 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2CCSCc2n1 InChI=1S/C13H11N3O3S2/c17-11-8(12-16(11)9(5-21-12)13(18)19)3-7-4-15-1-2-20-6-10(15)14-7/h3-5,12H,1-2,6H2,(H,18,19)/p-1/b8-3-/t12-/m1/s1 UAILHDKDBBFHDN-CPWLGJMPSA-M 50191383 (5R),(6Z)-6-(5,6-dihydro-8H-imidazo[2,1-c]-[1,4]thiazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL425963 Beta-lactamase TEM 3 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191383&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936187 104074501 CHEMBL425963 ZINC34717633 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353777 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C/c1cn2CCNCc2n1 InChI=1S/C13H12N4O3S/c18-11-8(12-17(11)9(6-21-12)13(19)20)3-7-5-16-2-1-14-4-10(16)15-7/h3,5-6,12,14H,1-2,4H2,(H,19,20)/p-1/b8-3+/t12-/m1/s1 SZEAVITUDYBJGA-STWLFGJUSA-M 50191380 CHEMBL379440::sodium (R,E)-7-oxo-6-((5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)methylene)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate Beta-lactamase TEM 5 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191380&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936184 104074498 CHEMBL379440 ZINC34093360 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353778 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 100 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353781 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cc2CCCCn2n1 InChI=1S/C14H13N3O3S/c18-12-10(13-17(12)11(7-21-13)14(19)20)6-8-5-9-3-1-2-4-16(9)15-8/h5-7,13H,1-4H2,(H,19,20)/p-1/b10-6-/t13-/m1/s1 XTADYNGCKRLHLU-AGEOTTOMSA-M 50191386 (5R)(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo-[1,5-a]pyridin-2-ylmethylene)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL385593 Beta-lactamase TEM 2 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191386&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936190 104074504 CHEMBL385593 ZINC34717634 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353786 CN1CCn2cc(\C=C3/[C@H]4SC=C(N4C3=O)C([O-])=O)nc2C1 InChI=1S/C14H14N4O3S/c1-16-2-3-17-5-8(15-11(17)6-16)4-9-12(19)18-10(14(20)21)7-22-13(9)18/h4-5,7,13H,2-3,6H2,1H3,(H,20,21)/p-1/b9-4-/t13-/m1/s1 MRXVYOLTKNEJHK-VVOKDJNJSA-M 50191387 (5R),(6Z)-6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-ylmethylene)-7-oxo-4-thia-1-aza-bicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL212478 Beta-lactamase TEM 4 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191387&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936191 104074505 CHEMBL212478 ZINC34717631 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50353787 [O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C/c1cn2CCSCc2n1 InChI=1S/C13H11N3O3S2/c17-11-8(12-16(11)9(5-21-12)13(18)19)3-7-4-15-1-2-20-6-10(15)14-7/h3-5,12H,1-2,6H2,(H,18,19)/p-1/b8-3+/t12-/m1/s1 UAILHDKDBBFHDN-STWLFGJUSA-M 50191384 (5R),(6E)-6-(5,6-dihydro-8H-imidazo[2,1-c][1,4]thiazin-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt::CHEMBL211889 Beta-lactamase TEM 730 ChEMBL 10.1021/jm060021p 10.7270/Q2TX3F1B 16854068 Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50191384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50191384&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936188 104074502 CHEMBL211889 ZINC34717638 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50396364 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 80 ChEMBL 10.1128/AAC.00614-07 10.7270/Q2H131TX 17709463 Robin, F; Delmas, J; Brebion, A; Dubois, D; Constantin, JM; Bonnet, R CHU Clermont-Ferrand http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50396366 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 130 ChEMBL 10.1128/AAC.00614-07 10.7270/Q2H131TX 17709463 Robin, F; Delmas, J; Brebion, A; Dubois, D; Constantin, JM; Bonnet, R CHU Clermont-Ferrand http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404420 OCCN(CCO)Cc1ccc2sc(cc2c1)B(O)O InChI=1S/C13H18BNO4S/c16-5-3-15(4-6-17)9-10-1-2-12-11(7-10)8-13(20-12)14(18)19/h1-2,7-8,16-19H,3-6,9H2 ZCHQBQNKHHGUIG-UHFFFAOYSA-N 50225372 CHEMBL235097::pinacol 5-{[bis(2-hydroxyethyl)amino]methyl}benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 1000 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225372&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655488 104096678 CHEMBL235097 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404421 Cc1ccc2sc(cc2c1)B(O)O InChI=1S/C9H9BO2S/c1-6-2-3-8-7(4-6)5-9(13-8)10(11)12/h2-5,11-12H,1H3 DHNHZPQPQAINDI-UHFFFAOYSA-N 50225371 5-methyl-benzo[b]thiophen-2-ylboronic acid::CHEMBL238243 Beta-lactamase TEM 30 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225371&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2794641 104096677 CHEMBL238243 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404422 OB(O)c1cc2ccccc2s1 InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H YNCYPMUJDDXIRH-UHFFFAOYSA-N 26139 1-benzothiophen-2-ylboranediol::1-benzothiophen-2-ylboronic acid, 18::CHEMBL34964::Phenylboronic acid, 11 Beta-lactamase TEM 27 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26139&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BZB 3FKV,4BD0,4BD1,3IXG,3IXB,1C3B,4C3Q 2359 56464576 CHEMBL34964 DB04360 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404423 OB(O)c1cc2cc(CNc3ccc(Cl)c(Cl)c3)ccc2s1 InChI=1S/C15H12BCl2NO2S/c17-12-3-2-11(7-13(12)18)19-8-9-1-4-14-10(5-9)6-15(22-14)16(20)21/h1-7,19-21H,8H2 WJLXVAIRFZLEMT-UHFFFAOYSA-N 50225373 CHEMBL396872::pinacol 5-[(3,4-dichlorophenylamino)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 10 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225373&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655482 104096679 CHEMBL396872 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404424 Nn1cn[n+](Cc2ccc3sc(cc3c2)B(O)O)c1 InChI=1S/C11H12BN4O2S/c13-15-6-14-16(7-15)5-8-1-2-10-9(3-8)4-11(19-10)12(17)18/h1-4,6-7,17-18H,5,13H2/q+1 OIJFJYAPZDYGLS-UHFFFAOYSA-N 50225374 5 [(1,2,4-triazol-1-ylmethyl]benzo[b]thiophen-2-ylboronic acid::CHEMBL235951 Beta-lactamase TEM 170 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225374&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655692 104096680 CHEMBL235951 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404425 Nc1ccc2sc(cc2c1)B(O)O InChI=1S/C8H8BNO2S/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4,11-12H,10H2 JKKGGMCLDMDJBH-UHFFFAOYSA-N 50225375 CHEMBL396390::pinacol 5-aminomethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 260 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225375&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 24742025 104096681 CHEMBL396390 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404426 OB(O)c1cc2cc(Br)ccc2s1 InChI=1S/C8H6BBrO2S/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4,11-12H RUQKSUMPFAJLNQ-UHFFFAOYSA-N 50225376 CHEMBL397522::pinacol 5-bromomethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 30 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225376&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23005355 104096682 CHEMBL397522 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404427 OB(O)c1cc2cc(COc3ccc(Cl)c(Cl)c3)ccc2s1 InChI=1S/C15H11BCl2O3S/c17-12-3-2-11(7-13(12)18)21-8-9-1-4-14-10(5-9)6-15(22-14)16(19)20/h1-7,19-20H,8H2 ORYFBEFEVAROPS-UHFFFAOYSA-N 50225377 CHEMBL237390::pinacol 5-(3,4-dichlorophenoxymethyl)benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 83 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225377&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655484 104096683 CHEMBL237390 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404428 OB(O)c1cc2cc(CN(C=O)C=O)ccc2s1 InChI=1S/C11H10BNO4S/c14-6-13(7-15)5-8-1-2-10-9(3-8)4-11(18-10)12(16)17/h1-4,6-7,16-17H,5H2 GVTZPLCQJFQOTQ-UHFFFAOYSA-N 50225378 CHEMBL235073::pinacol 5-diformylaminomethylbenzo[b]thiophen-2-ylboronate::{5-[(DIFORMYLAMINO)METHYL]-1-BENZOTHIEN-2-YL}BORONIC ACID Beta-lactamase TEM 37 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225378&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search VA1 2I72 23655305 104096684 CHEMBL235073 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404429 OB(O)c1cc2cc(CNc3ccc(cc3)C(O)(C(F)(F)F)C(F)(F)F)ccc2s1 InChI=1S/C18H14BF6NO3S/c20-17(21,22)16(27,18(23,24)25)12-2-4-13(5-3-12)26-9-10-1-6-14-11(7-10)8-15(30-14)19(28)29/h1-8,26-29H,9H2 AGZMSTRZJHCCDI-UHFFFAOYSA-N 50225381 CHEMBL235293::pinacol5-{[4-(1-hydroxy-2,2,2-trifluoro-1-trifluoromethylethyl)-phenylamino]methyl}benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 28 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225381&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655481 104096687 CHEMBL235293 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404430 OB(O)c1cc2cc(CNc3cccc(c3)[N+]([O-])=O)ccc2s1 InChI=1S/C15H13BN2O4S/c19-16(20)15-7-11-6-10(4-5-14(11)23-15)9-17-12-2-1-3-13(8-12)18(21)22/h1-8,17,19-20H,9H2 XVMINMUHFBYDMD-UHFFFAOYSA-N 50225379 CHEMBL235292::pinacol 5-[(3-nitrophenylamino)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 37 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225379&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655308 104096685 CHEMBL235292 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404431 OB(O)c1cc2cc(CNC=O)ccc2s1 InChI=1S/C10H10BNO3S/c13-6-12-5-7-1-2-9-8(3-7)4-10(16-9)11(14)15/h1-4,6,14-15H,5H2,(H,12,13) HGLTXGPYNBUTBC-UHFFFAOYSA-N 50225384 5-formylaminomethylbenzo[b]thiophen-2-ylboronic acid::CHEMBL235291 Beta-lactamase TEM 450 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225384&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655307 104096690 CHEMBL235291 C06049 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404432 OB(O)c1cc2cc(CNc3cccc(c3)B(O)O)ccc2s1 InChI=1S/C15H15B2NO4S/c19-16(20)12-2-1-3-13(8-12)18-9-10-4-5-14-11(6-10)7-15(23-14)17(21)22/h1-8,18-22H,9H2 DDMLJZBFSFVMIE-UHFFFAOYSA-N 50225380 CHEMBL235308::pinacol 5-[(phenylamino3-boronicacid)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 45 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225380&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655685 104096686 CHEMBL235308 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404433 OB(O)C1=CCCS1 InChI=1S/C4H7BO2S/c6-5(7)4-2-1-3-8-4/h2,6-7H,1,3H2 HBWATGYSAHIWIX-UHFFFAOYSA-N 50225388 CHEMBL236759::thiophene-2-ylboronic acid Beta-lactamase TEM 2500 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225388&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44435718 104096694 CHEMBL236759 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404434 OB(O)c1cc2cc(Cn3ccnc3)ccc2s1 InChI=1S/C12H11BN2O2S/c16-13(17)12-6-10-5-9(1-2-11(10)18-12)7-15-4-3-14-8-15/h1-6,8,16-17H,7H2 PUCQEQODRLZNBJ-UHFFFAOYSA-N 50225389 5-imidazol-1-yl-methylbenzo[b]thiophen-2-ylboronic acid::CHEMBL395186 Beta-lactamase TEM 82 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225389&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655690 104096695 CHEMBL395186 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404435 OB(O)c1cc2cc(CNc3ccc(cc3)N3CCOCC3)ccc2s1 InChI=1S/C19H21BN2O3S/c23-20(24)19-12-15-11-14(1-6-18(15)26-19)13-21-16-2-4-17(5-3-16)22-7-9-25-10-8-22/h1-6,11-12,21,23-24H,7-10,13H2 XERIMYALBKZDJZ-UHFFFAOYSA-N 50225385 CHEMBL391537::pinacol 5-[(4-morpholin-4-yl-phenylamino)methyl]benzo[b]-thiophen-2-ylboronate Beta-lactamase TEM 800 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225385&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655688 104096691 CHEMBL391537 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404436 OB(O)c1cc2cc(CN3CCNCC3)ccc2s1 InChI=1S/C13H17BN2O2S/c17-14(18)13-8-11-7-10(1-2-12(11)19-13)9-16-5-3-15-4-6-16/h1-2,7-8,15,17-18H,3-6,9H2 AKBSFHBVPHVWIW-UHFFFAOYSA-N 50225382 CHEMBL398112::pinacol 5-piperazin-1-ylmethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 2000 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225382&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655684 104096688 CHEMBL398112 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404437 OB(O)c1cc2cc(COc3ccccc3)ccc2s1 InChI=1S/C15H13BO3S/c17-16(18)15-9-12-8-11(6-7-14(12)20-15)10-19-13-4-2-1-3-5-13/h1-9,17-18H,10H2 KUVZFYLSYWXFBD-UHFFFAOYSA-N 50225386 CHEMBL396871::pinacol 5-phenoxymethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 250 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225386&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655483 104096692 CHEMBL396871 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404438 COc1ccc(NCc2ccc3sc(cc3c2)B(O)O)cc1OC InChI=1S/C17H18BNO4S/c1-22-14-5-4-13(9-15(14)23-2)19-10-11-3-6-16-12(7-11)8-17(24-16)18(20)21/h3-9,19-21H,10H2,1-2H3 IQEFBPFYMDWCHP-UHFFFAOYSA-N 50225387 CHEMBL396889::pinacol 5-[(3,4-dimethoxyphenylamino)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 250 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225387&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655487 104096693 CHEMBL396889 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404439 OB(O)c1cc2cc(CSc3ccccc3)ccc2s1 InChI=1S/C15H13BO2S2/c17-16(18)15-9-12-8-11(6-7-14(12)20-15)10-19-13-4-2-1-3-5-13/h1-9,17-18H,10H2 NKBQQHAXUYEGJK-UHFFFAOYSA-N 50225383 CHEMBL236203::pinacol 5-phenylsulphanylmethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 80 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225383&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655486 104096689 CHEMBL236203 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404440 CC(=O)c1ccc(NCc2ccc3sc(cc3c2)B(O)O)cc1 InChI=1S/C17H16BNO3S/c1-11(20)13-3-5-15(6-4-13)19-10-12-2-7-16-14(8-12)9-17(23-16)18(21)22/h2-9,19,21-22H,10H2,1H3 HSPMSGHIXSXVHR-UHFFFAOYSA-N 50225390 CHEMBL235523::pinacol 5-[(4-acetylphenylamino)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 250 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225390&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655686 104096696 CHEMBL235523 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404441 OB(O)c1cc2cc(COCc3ccccc3)ccc2s1 InChI=1S/C16H15BO3S/c18-17(19)16-9-14-8-13(6-7-15(14)21-16)11-20-10-12-4-2-1-3-5-12/h1-9,18-19H,10-11H2 FQAPYKJKLMNWLX-UHFFFAOYSA-N 50225391 CHEMBL237181::pinacol 5-benzyloxymethylbenzo[b]thiophen-2-ylboronate Beta-lactamase TEM 600 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225391&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655485 104096697 CHEMBL237181 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404442 OB(O)c1cc2cc(O)ccc2s1 InChI=1S/C8H7BO3S/c10-6-1-2-7-5(3-6)4-8(13-7)9(11)12/h1-4,10-12H VDCIKADVYWVDGT-UHFFFAOYSA-N 50225392 5-hydroxymethylbenzo[b]thiophen-2-ylboronic acid::CHEMBL395398 Beta-lactamase TEM 43 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225392&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44435712 104096698 CHEMBL395398 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50404443 OB(O)c1cc2cc(CNCC(O)=O)ccc2s1 InChI=1S/C11H12BNO4S/c14-11(15)6-13-5-7-1-2-9-8(3-7)4-10(18-9)12(16)17/h1-4,13,16-17H,5-6H2,(H,14,15) VRCPBICEVAIMRL-UHFFFAOYSA-N 50225393 CHEMBL235526::pinacol 5-[(carboxymethylamino)methyl]benzo[b]thiophen-2-ylboronate Beta-lactamase TEM 28 ChEMBL 10.1021/jm070643q 10.7270/Q21N80W5 17956081 Venturelli, A; Tondi, D; Cancian, L; Morandi, F; Cannazza, G; Segatore, B; Prati, F; Amicosante, G; Shoichet, BK; Costi, MP Università degli Studi di Modena e Reggio Emilia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225393&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23655689 104096699 CHEMBL235526 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724643 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C([O-])=O)C2=O)C([O-])=O InChI=1S/C12H11NO7S/c1-5(14)20-3-6-4-21-11-7(2-8(15)16)10(17)13(11)9(6)12(18)19/h2,11H,3-4H2,1H3,(H,15,16)(H,18,19)/p-2/b7-2-/t11-/m1/s1 MDAINRPXGSCIOC-IGVIJBNESA-L 50284785 (6R,7Z)-3-[(acetyloxy)methyl]-7-(2-oxido-2-oxoethylidene)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; sodium salt::CHEMBL36888 Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284785&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934800 104126356 CHEMBL36888 ZINC29314880 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724648 CC(=O)OCC1=C(N2[C@@H](\C(=C/C(=O)OC(C)(C)C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C16H19NO9S/c1-8(18)25-6-9-7-27(23,24)14-10(5-11(19)26-16(2,3)4)13(20)17(14)12(9)15(21)22/h5,14H,6-7H2,1-4H3,(H,21,22)/p-1/b10-5-/t14-/m1/s1 LQVZDTYWLLBGHZ-XTXQVDMPSA-M 50033680 CHEMBL268919::Sodium; (R)-3-acetoxymethyl-7-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 5 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929126 103941940 CHEMBL268919 ZINC03949252 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724649 CC(C)(C)OC(=O)\C=C1/[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O InChI=1S/C14H19NO5S/c1-13(2,3)20-8(16)6-7-10(17)15-9(12(18)19)14(4,5)21-11(7)15/h6,9,11H,1-5H3,(H,18,19)/p-1/b7-6-/t9-,11+/m0/s1 BQYSWXZGFUSYTK-RWTFEVOBSA-M 50284788 CHEMBL33895::Sodium; (2S,5R)-6-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284788&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934803 104126359 CHEMBL33895 ZINC29251104 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724653 CC1(C)[C@@H](N2[C@@H](\C(=C/C([O-])=O)C2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H11NO7S/c1-10(2)6(9(15)16)11-7(14)4(3-5(12)13)8(11)19(10,17)18/h3,6,8H,1-2H3,(H,12,13)(H,15,16)/p-2/b4-3-/t6-,8+/m0/s1 BFVDGHQWCMHZCR-YRNGGQEVSA-L 50284789 (2S,5R,6Z)-6-(carboxymethylene)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide;sodium salt::CHEMBL287095 Beta-lactamase TEM 120 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284789&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934804 104126360 CHEMBL287095 ZINC26159467 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724654 CC(=O)C=C1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O InChI=1S/C11H13NO4S/c1-5(13)4-6-8(14)12-7(10(15)16)11(2,3)17-9(6)12/h4,7,9H,1-3H3,(H,15,16)/p-1/t7-,9+/m0/s1 IKGZFJCMJFERPR-IONNQARKSA-M 50284790 CHEMBL35987::Sodium; (2S,5R)-3,3-dimethyl-7-oxo-6-[2-oxo-prop-(Z)-ylidene]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 3 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284790&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934805 104126361 CHEMBL35987 ZINC05159243 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724655 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 25 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724657 COC(=O)\C=C1/[C@@H]2N([C@@H](C([O-])=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C11H13NO7S/c1-11(2)7(10(15)16)12-8(14)5(4-6(13)19-3)9(12)20(11,17)18/h4,7,9H,1-3H3,(H,15,16)/p-1/b5-4-/t7-,9+/m0/s1 LTSHHIPSCFMNJJ-LZUCFRIBSA-M 50284784 CHEMBL290112::Sodium; (2S,5R)-6-[1-methoxycarbonyl-meth-(Z)-ylidene]-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 308 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284784&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934799 104126355 CHEMBL290112 ZINC29323278 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724660 CC(=O)OCC1=C(N2[C@@H](C(=C=C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C12H11NO7S/c1-3-8-10(15)13-9(12(16)17)7(4-20-6(2)14)5-21(18,19)11(8)13/h11H,1,4-5H2,2H3,(H,16,17)/p-1/t11-/m1/s1 ZLYQUOKXGNQRIC-LLVKDONJSA-M 50284794 CHEMBL36689::Sodium; (R)-3-acetoxymethyl-5,5,8-trioxo-7-vinylidene-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284794&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934808 104126365 CHEMBL36689 ZINC29317483 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724664 CC(=O)OCC1=C(N2[C@@H](C(=C)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C11H11NO7S/c1-5-9(14)12-8(11(15)16)7(3-19-6(2)13)4-20(17,18)10(5)12/h10H,1,3-4H2,2H3,(H,15,16)/p-1/t10-/m1/s1 SUKFPPMYJISQEB-SNVBAGLBSA-M 50284783 CHEMBL37794::Sodium; (R)-3-acetoxymethyl-7-methylene-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 800 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284783&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934798 104126354 CHEMBL37794 ZINC29313394 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724666 CC(=O)OCC1=C(N2[C@@H](\C(=C/C([O-])=O)C2=O)S(=O)(=O)C1)C([O-])=O InChI=1S/C12H11NO9S/c1-5(14)22-3-6-4-23(20,21)11-7(2-8(15)16)10(17)13(11)9(6)12(18)19/h2,11H,3-4H2,1H3,(H,15,16)(H,18,19)/p-2/b7-2-/t11-/m1/s1 OWSYJEORPQIBAC-IGVIJBNESA-L 50284792 (6R,7Z)-3-[(acetyloxy)methyl]-7-(2-oxido-2-oxoethylidene)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide; sodium salt::CHEMBL290165 Beta-lactamase TEM 400 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284792&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934806 104126363 CHEMBL290165 ZINC29318833 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724667 COC(=O)\C=C1/[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O InChI=1S/C11H13NO5S/c1-11(2)7(10(15)16)12-8(14)5(9(12)18-11)4-6(13)17-3/h4,7,9H,1-3H3,(H,15,16)/p-1/b5-4-/t7-,9+/m0/s1 WMEHQPKGOVJLPV-LZUCFRIBSA-M 50284795 CHEMBL36213::Sodium; (2S,5R)-6-[1-methoxycarbonyl-meth-(Z)-ylidene]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284795&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934809 104126366 CHEMBL36213 ZINC29315749 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724671 COC(=O)\C=C1/[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O InChI=1S/C13H13NO7S/c1-6(15)21-4-7-5-22-12-8(3-9(16)20-2)11(17)14(12)10(7)13(18)19/h3,12H,4-5H2,1-2H3,(H,18,19)/p-1/b8-3-/t12-/m1/s1 AOZHCLHLXLZFCC-CPWLGJMPSA-M 50284787 CHEMBL34981::Sodium; (R)-3-acetoxymethyl-7-[1-methoxycarbonyl-meth-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284787&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934802 104126358 CHEMBL34981 ZINC29252967 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724676 COC(=O)\C=C1/[C@@H]2N(C1=O)C(C([O-])=O)=C(COC(C)=O)CS2(=O)=O InChI=1S/C13H13NO9S/c1-6(15)23-4-7-5-24(20,21)12-8(3-9(16)22-2)11(17)14(12)10(7)13(18)19/h3,12H,4-5H2,1-2H3,(H,18,19)/p-1/b8-3-/t12-/m1/s1 IOZBBLWTTHEQCC-CPWLGJMPSA-M 50284786 CHEMBL36657::Sodium; (R)-3-acetoxymethyl-7-[1-methoxycarbonyl-meth-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM 37 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284786&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934801 104126357 CHEMBL36657 ZINC29313321 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724677 CC(C)(C)OC(=O)\C=C1/[C@@H]2N([C@@H](C([O-])=O)C(C)(C)S2(=O)=O)C1=O InChI=1S/C14H19NO7S/c1-13(2,3)22-8(16)6-7-10(17)15-9(12(18)19)14(4,5)23(20,21)11(7)15/h6,9,11H,1-5H3,(H,18,19)/p-1/b7-6-/t9-,11+/m0/s1 OWOUVVRZHCNSFW-RWTFEVOBSA-M 50284793 CHEMBL284539::Sodium; (2S,5R)-6-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-3,3-dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 136 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284793&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91934807 104126364 CHEMBL284539 ZINC29317726 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724679 CC1(C)S[C@H]2N([C@H]1C([O-])=O)C(=O)\C2=C\C([O-])=O InChI=1S/C10H11NO5S/c1-10(2)6(9(15)16)11-7(14)4(3-5(12)13)8(11)17-10/h3,6,8H,1-2H3,(H,12,13)(H,15,16)/p-2/b4-3-/t6-,8+/m0/s1 BJXIZXYMGFDKBP-YRNGGQEVSA-L 50284796 (6Z)-6-(carboxymethylene)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; sodium salt::CHEMBL39640 Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50284796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50284796&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23257456 104126367 CHEMBL39640 ZINC29325097 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724685 CC(=O)OCC1=C(N2[C@H](SC1)\C(=C/C(=O)OC(C)(C)C)C2=O)C([O-])=O InChI=1S/C16H19NO7S/c1-8(18)23-6-9-7-25-14-10(5-11(19)24-16(2,3)4)13(20)17(14)12(9)15(21)22/h5,14H,6-7H2,1-4H3,(H,21,22)/p-1/b10-5-/t14-/m1/s1 KKHROROKABOCRS-XTXQVDMPSA-M 50033696 CHEMBL269308::Sodium; (R)-3-acetoxymethyl-7-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Beta-lactamase TEM >20000 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033696&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91929140 103941955 CHEMBL269308 ZINC03826255 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50724688 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 60 ChEMBL 10.1016/0960-894X(95)00249-S 10.7270/Q2ZW1MDG Buynak, JD; Geng, B; Bachmann, B; Ling, Hua TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50737431 C\C=C1/[C@H]2C3CSCCC3=C(N2C1=O)C([O-])=O InChI=1S/C12H13NO3S/c1-2-6-9-8-5-17-4-3-7(8)10(12(15)16)13(9)11(6)14/h2,8-9H,3-5H2,1H3,(H,15,16)/p-1/b6-2+/t8?,9-/m0/s1 CJHIIEVRZUZNQE-XBIFLVPGSA-M 50112047 CHEMBL176949::Sodium; (R)-2-eth-(E)-ylidene-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylate Beta-lactamase TEM 100000 ChEMBL 10.1016/s0960-894x(02)00061-6 10.7270/Q2NC61S9 11959006 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Lek d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112047&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931940 104006560 CHEMBL176949 ZINC13587042 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50737433 C\C=C1/[C@@H]2C3CCCCC3=C(N2C1=O)C([O-])=O InChI=1S/C13H15NO3/c1-2-7-10-8-5-3-4-6-9(8)11(13(16)17)14(10)12(7)15/h2,8,10H,3-6H2,1H3,(H,16,17)/p-1/b7-2+/t8?,10-/m1/s1 CIJAZLWHLDAZJS-SQXGTUSBSA-M 50112048 CHEMBL368418::Sodium; (S)-1-eth-(E)-ylidene-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylate Beta-lactamase TEM 39000 ChEMBL 10.1016/s0960-894x(02)00061-6 10.7270/Q2NC61S9 11959006 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Lek d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112048&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931941 104006561 CHEMBL368418 ZINC28105445 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50737436 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 25000 ChEMBL 10.1016/s0960-894x(02)00061-6 10.7270/Q2NC61S9 11959006 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Lek d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50737437 C\C=C1/[C@@H]2C3CSCCC3=C(N2C1=O)C([O-])=O InChI=1S/C12H13NO3S/c1-2-6-9-8-5-17-4-3-7(8)10(12(15)16)13(9)11(6)14/h2,8-9H,3-5H2,1H3,(H,15,16)/p-1/b6-2+/t8?,9-/m1/s1 CJHIIEVRZUZNQE-QKAYSLHJSA-M 50112051 CHEMBL175015::Sodium; (S)-2-eth-(E)-ylidene-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylate Beta-lactamase TEM 32000 ChEMBL 10.1016/s0960-894x(02)00061-6 10.7270/Q2NC61S9 11959006 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Lek d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112051&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931943 104006564 CHEMBL175015 ZINC28096675 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50737438 C\C=C1/[C@H]2C3CCCCC3=C(N2C1=O)C([O-])=O InChI=1S/C13H15NO3/c1-2-7-10-8-5-3-4-6-9(8)11(13(16)17)14(10)12(7)15/h2,8,10H,3-6H2,1H3,(H,16,17)/p-1/b7-2+/t8?,10-/m0/s1 CIJAZLWHLDAZJS-FVFDJMOISA-M 50112049 CHEMBL174970::Sodium; (R)-1-eth-(E)-ylidene-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylate Beta-lactamase TEM 120000 ChEMBL 10.1016/s0960-894x(02)00061-6 10.7270/Q2NC61S9 11959006 Copar, A; Prevec, T; Anzic, B; Mesar, T; Selic, L; Vilar, M; Solmajer, T Lek d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112049&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91931942 104006562 CHEMBL174970 ZINC13587040 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50777272 C[C@]1(\C=C\C#N)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C10H10N2O5S/c1-10(3-2-4-11)8(9(14)15)12-6(13)5-7(12)18(10,16)17/h2-3,7-8H,5H2,1H3,(H,14,15)/p-1/b3-2+/t7-,8+,10+/m1/s1 JYGFUXUBGZBBAC-RCRIAUEHSA-M 50076680 CHEMBL6461::Ro-48-1220::Sodium; (2S,3R,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate::Sodium; (2S,3S,5R)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate Beta-lactamase TEM 130 ChEMBL 10.1021/jm9601967 10.7270/Q2ZK5H99 8809160 Richter, HG; Angehrn, P; Hubschwerlen, C; Kania, M; Page, MG; Specklin, JL; Winkler, FK F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076680&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22873173 103969551 CHEMBL6461 ZINC13604487 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50814990 [O-]C(=O)c1ccccc1C(=C1C=C(I)C(=O)C(I)=C1)c1cc(I)c([O-])c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)18(13)25)17(10-7-15(23)19(26)16(24)8-10)11-3-1-2-4-12(11)20(27)28/h1-8,25H,(H,27,28)/p-2 KVFPRLVRGPLMDH-UHFFFAOYSA-L 50111589 2-[(3,5-diiodo-4-oxidophenyl)(3,5-diiodo-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate::2-[3,5-diiodo-4-olatophenyl(3,5-diiodo-4-oxo-2,5-cyclohexadienyliden)methyl]benzoate Beta-lactamase TEM 3000 ChEMBL 10.1021/jm030266r 10.7270/Q29C6Z59 13678405 McGovern, SL; Helfand, BT; Feng, B; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111589&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 3770186 104006127 29067 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50815000 [O-]C(=O)c1ccccc1C(=C1C=C(I)C(=O)C(I)=C1)c1cc(I)c([O-])c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)18(13)25)17(10-7-15(23)19(26)16(24)8-10)11-3-1-2-4-12(11)20(27)28/h1-8,25H,(H,27,28)/p-2 KVFPRLVRGPLMDH-UHFFFAOYSA-L 50111589 2-[(3,5-diiodo-4-oxidophenyl)(3,5-diiodo-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate::2-[3,5-diiodo-4-olatophenyl(3,5-diiodo-4-oxo-2,5-cyclohexadienyliden)methyl]benzoate Beta-lactamase TEM 7000 ChEMBL 10.1021/jm030266r 10.7270/Q29C6Z59 13678405 McGovern, SL; Helfand, BT; Feng, B; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111589&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 3770186 104006127 29067 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50815002 [O-]C(=O)c1ccccc1C(=C1C=C(I)C(=O)C(I)=C1)c1cc(I)c([O-])c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)18(13)25)17(10-7-15(23)19(26)16(24)8-10)11-3-1-2-4-12(11)20(27)28/h1-8,25H,(H,27,28)/p-2 KVFPRLVRGPLMDH-UHFFFAOYSA-L 50111589 2-[(3,5-diiodo-4-oxidophenyl)(3,5-diiodo-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate::2-[3,5-diiodo-4-olatophenyl(3,5-diiodo-4-oxo-2,5-cyclohexadienyliden)methyl]benzoate Beta-lactamase TEM 3000 ChEMBL 10.1021/jm030266r 10.7270/Q29C6Z59 13678405 McGovern, SL; Helfand, BT; Feng, B; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111589&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 3770186 104006127 29067 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50815008 [O-]C(=O)c1ccccc1C(=C1C=C(I)C(=O)C(I)=C1)c1cc(I)c([O-])c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)18(13)25)17(10-7-15(23)19(26)16(24)8-10)11-3-1-2-4-12(11)20(27)28/h1-8,25H,(H,27,28)/p-2 KVFPRLVRGPLMDH-UHFFFAOYSA-L 50111589 2-[(3,5-diiodo-4-oxidophenyl)(3,5-diiodo-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate::2-[3,5-diiodo-4-olatophenyl(3,5-diiodo-4-oxo-2,5-cyclohexadienyliden)methyl]benzoate Beta-lactamase TEM 3000 ChEMBL 10.1021/jm030266r 10.7270/Q29C6Z59 13678405 McGovern, SL; Helfand, BT; Feng, B; Shoichet, BK Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111589&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 3770186 104006127 29067 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848058 CCCCO[C@@H]1CCC[C@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 InChI=1S/C17H23NO4/c1-3-5-9-22-12-8-6-7-11-13(12)15(17(20)21)18-14(11)10(4-2)16(18)19/h4,11-12,14H,3,5-9H2,1-2H3,(H,20,21)/p-1/b10-4+/t11-,12-,14+/m1/s1 ZZWPJCNMJSBJDZ-UHEBKQLESA-M 50218932 CHEMBL396998::sodium (8R,9R)-10(S)-[1(R)-hydroxyethyl]-4(R)-butoxy-11-oxo-1-azatricyclo[7.2.0 .03,8]undec-2-enecarboxylate Beta-lactamase TEM 12 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218932&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936030 104092390 CHEMBL396998 ZINC28710918 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848060 C\C=C1/[C@H]2[C@H]3CCC[C@H](OCCF)C3=C(N2C1=O)C([O-])=O InChI=1S/C15H18FNO4/c1-2-8-12-9-4-3-5-10(21-7-6-16)11(9)13(15(19)20)17(12)14(8)18/h2,9-10,12H,3-7H2,1H3,(H,19,20)/p-1/b8-2+/t9-,10-,12-/m0/s1 OVEFSUBTHUNTRK-JCKKZLPESA-M 50218934 CHEMBL395017::sodium (8S,9R)-10(E)-ethylidene-4(S)-(2'-fluoroethoxy)-11-oxo-1-azatricyclo[7.2.0.03, 8]undec-2-enecarboxylate Beta-lactamase TEM 21 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218934&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936032 104092392 CHEMBL395017 ZINC28710920 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848063 CCO[C@H]1CCC[C@@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 InChI=1S/C15H19NO4/c1-3-8-12-9-6-5-7-10(20-4-2)11(9)13(15(18)19)16(12)14(8)17/h3,9-10,12H,4-7H2,1-2H3,(H,18,19)/p-1/b8-3+/t9-,10-,12-/m0/s1 KYVATCVZAZHVGK-SCMGXACRSA-M 50218937 CHEMBL230226::sodium (8S,9R)-10(E)-ethylidene-4(S)-ethoxy-11-oxo-1-azatricyclo[7.2.0.03,8]undec-2 -enecarboxylate Beta-lactamase TEM 57 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218937&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936035 104092395 CHEMBL230226 ZINC28710916 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848066 CCCCO[C@H]1CCC[C@@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 InChI=1S/C17H23NO4/c1-3-5-9-22-12-8-6-7-11-13(12)15(17(20)21)18-14(11)10(4-2)16(18)19/h4,11-12,14H,3,5-9H2,1-2H3,(H,20,21)/p-1/b10-4+/t11-,12-,14-/m0/s1 ZZWPJCNMJSBJDZ-GNURROEBSA-M 50218939 CHEMBL230332::sodium (5S,8aS,8bR)-5-butoxy-1-eth-(E)-ylidene-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylate Beta-lactamase TEM 32 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218939&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936037 104092397 CHEMBL230332 ZINC28710919 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848069 C\C=C1/[C@H]2[C@H]3CCC[C@H](OCCC#N)C3=C(N2C1=O)C([O-])=O InChI=1S/C16H18N2O4/c1-2-9-13-10-5-3-6-11(22-8-4-7-17)12(10)14(16(20)21)18(13)15(9)19/h2,10-11,13H,3-6,8H2,1H3,(H,20,21)/p-1/b9-2+/t10-,11-,13-/m0/s1 FUPMZGCETKRXTR-FFKCEWRFSA-M 50218936 CHEMBL397438::sodium (8S,9R)-10(E)-ethylidene-4(S)-(2'-cyanoethoxy)-11-oxo-1-azatricyclo[7.2.0.03, 8]undec-2-enecarboxylate Beta-lactamase TEM 18 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218936&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936034 104092394 CHEMBL397438 ZINC28710921 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848070 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 30 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848072 CCO[C@@H]1CCC[C@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 InChI=1S/C15H19NO4/c1-3-8-12-9-6-5-7-10(20-4-2)11(9)13(15(18)19)16(12)14(8)17/h3,9-10,12H,4-7H2,1-2H3,(H,18,19)/p-1/b8-3+/t9-,10-,12+/m1/s1 KYVATCVZAZHVGK-WOCUHLHXSA-M 50218933 CHEMBL230859::sodium (8R,9R)-10(E)-ethylidene-4(R)-ethoxy-11-oxo-1-azatricyclo[7.2.0.03,8]undec-2 -enecarboxylate Beta-lactamase TEM 22 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218933&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936031 104092391 CHEMBL230859 ZINC28710915 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848074 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 17 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848075 CO[C@H]1CCC[C@@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 InChI=1S/C14H17NO4/c1-3-7-11-8-5-4-6-9(19-2)10(8)12(14(17)18)15(11)13(7)16/h3,8-9,11H,4-6H2,1-2H3,(H,17,18)/p-1/b7-3+/t8-,9-,11-/m0/s1 ACQFJWSLWQLLIA-PLWQYUFKSA-M 50218935 CHEMBL396509::sodium (8S,9R)-10(E)-ethylidene-4(S)-methoxy-11-oxo-1-azatricyclo[7.2.0.03,8]undec -2-enecarboxylate Beta-lactamase TEM 55 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218935&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936033 104092393 CHEMBL396509 ZINC28710914 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50848080 C\C=C1/[C@H]2[C@H]3CCC[C@H](OC(C)C)C3=C(N2C1=O)C([O-])=O InChI=1S/C16H21NO4/c1-4-9-13-10-6-5-7-11(21-8(2)3)12(10)14(16(19)20)17(13)15(9)18/h4,8,10-11,13H,5-7H2,1-3H3,(H,19,20)/p-1/b9-4+/t10-,11-,13-/m0/s1 VDZDNZXKYYQECM-UIXYVRDFSA-M 50218938 CHEMBL396753::sodium (8S,9R)-10(E)-ethylidene-4(S)-isopropoxy-11-oxo-1-azatricyclo[7.2.0.03,8]undec-2-enecarboxylate Beta-lactamase TEM 39 ChEMBL 10.1021/jm0703237 10.7270/Q2FF3T5F 17665896 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T Lek Pharmaceuticals d.d. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218938&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91936036 104092396 CHEMBL396753 ZINC28710917 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50865592 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 170 ChEMBL 10.1128/AAC.01439-06 10.7270/Q2028SFP 17353248 Papagiannitsis, CC; Loli, A; Tzouvelekis, LS; Tzelepi, E; Arlet, G; Miriagou, V Institut Pasteur Hellenique http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50865593 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 7300 ChEMBL 10.1128/AAC.01439-06 10.7270/Q2028SFP 17353248 Papagiannitsis, CC; Loli, A; Tzouvelekis, LS; Tzelepi, E; Arlet, G; Miriagou, V Institut Pasteur Hellenique http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50865594 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 90 ChEMBL 10.1128/AAC.01439-06 10.7270/Q2028SFP 17353248 Papagiannitsis, CC; Loli, A; Tzouvelekis, LS; Tzelepi, E; Arlet, G; Miriagou, V Institut Pasteur Hellenique http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50984718 C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CCO[C@@H]3CN)=C(N2C1=O)C(O)=O InChI=1S/C15H22N2O5S/c1-6-11-10(7(2)18)14(19)17(11)12(15(20)21)13(6)23-9-3-4-22-8(9)5-16/h6-11,18H,3-5,16H2,1-2H3,(H,20,21)/t6-,7-,8-,9-,10-,11-/m1/s1 HTXPDRHSGPNWKA-VRGHXPGPSA-N 50403733 CHEMBL1206880::CL-191121 Beta-lactamase TEM 35 ChEMBL 10.1016/s0960-894x(99)00106-7 10.7270/Q2TB163Q 10230626 Bitha, P; Li, Z; Francisco, GD; Rasmussen, BA; Lin, YI Wyeth-Ayerst Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403733&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9906050 163352757 CHEMBL1206880 ZINC03808350 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557835 C[C@@]1(CSc2nc3ccccc3o2)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C15H13BrN2O4S2/c1-15(6-23-14-17-7-4-2-3-5-8(7)22-14)10(13(20)21)18-11(19)9(16)12(18)24-15/h2-5,9-10,12H,6H2,1H3,(H,20,21)/t9-,10+,12-,15+/m1/s1 XJAMHNGKVYJQKN-HMDURAKOSA-N 50212642 CHEMBL70269 Beta-lactamase TEM 30.3 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212642&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311970 376070551 CHEMBL70269 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557841 Cn1cnnc1SC[C@@]1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C11H14N4O5S2/c1-11(4-21-10-13-12-5-14(10)2)8(9(17)18)15-6(16)3-7(15)22(11,19)20/h5,7-8H,3-4H2,1-2H3,(H,17,18)/t7-,8+,11+/m1/s1 QDJWMEGFGPTSBD-FYBVGQRMSA-N 50212640 CHEMBL423309 Beta-lactamase TEM 72.2 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212640&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311943 376070549 CHEMBL423309 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557844 C[C@@]1(CSc2nc[nH]n2)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C10H11BrN4O3S2/c1-10(2-19-9-12-3-13-14-9)5(8(17)18)15-6(16)4(11)7(15)20-10/h3-5,7H,2H2,1H3,(H,17,18)(H,12,13,14)/t4-,5+,7-,10+/m1/s1 DVGGIJLCNIHENJ-ASTPYSOASA-N 50212645 CHEMBL305908 Beta-lactamase TEM 21.1 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212645&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44312264 376070554 CHEMBL305908 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557847 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 557 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557861 C[C@@]1(CSc2nc3ccccc3s2)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C15H13BrN2O3S3/c1-15(6-22-14-17-7-4-2-3-5-8(7)23-14)10(13(20)21)18-11(19)9(16)12(18)24-15/h2-5,9-10,12H,6H2,1H3,(H,20,21)/t9-,10+,12-,15+/m1/s1 WOFAABWEQYFPBT-HMDURAKOSA-N 50212643 CHEMBL308516 Beta-lactamase TEM 35.9 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212643&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311944 376070552 CHEMBL308516 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558168 C[C@]1(CSc2nc3ccccc3[nH]2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C15H15N3O5S2/c1-15(7-24-14-16-8-4-2-3-5-9(8)17-14)12(13(20)21)18-10(19)6-11(18)25(15,22)23/h2-5,11-12H,6-7H2,1H3,(H,16,17)(H,20,21)/t11-,12+,15+/m1/s1 ANZJFEYHQKFAQH-XUJVJEKNSA-N 50212646 CHEMBL72972 Beta-lactamase TEM 65.5 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212646&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311985 376070555 CHEMBL72972 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558169 C[C@]1(CSC2=NCCS2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C11H14N2O5S3/c1-11(5-20-10-12-2-3-19-10)8(9(15)16)13-6(14)4-7(13)21(11,17)18/h7-8H,2-5H2,1H3,(H,15,16)/t7-,8+,11+/m1/s1 MXCGPVVSKSQZRV-FYBVGQRMSA-N 50212637 CHEMBL72046 Beta-lactamase TEM 22.8 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212637&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311932 376070546 CHEMBL72046 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558495 Cn1ccnc1SC[C@@]1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C12H15N3O5S2/c1-12(6-21-11-13-3-4-14(11)2)9(10(17)18)15-7(16)5-8(15)22(12,19)20/h3-4,8-9H,5-6H2,1-2H3,(H,17,18)/t8-,9+,12+/m1/s1 RROHCWIBSPHGHX-PTRXPTGYSA-N 50212639 CHEMBL302241 Beta-lactamase TEM 289 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212639&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311971 376070548 CHEMBL302241 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558500 C[C@]1(CSc2nc3ccccc3o2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C15H14N2O6S2/c1-15(7-24-14-16-8-4-2-3-5-9(8)23-14)12(13(19)20)17-10(18)6-11(17)25(15,21)22/h2-5,11-12H,6-7H2,1H3,(H,19,20)/t11-,12+,15+/m1/s1 QOMLCKUMUUKMOX-XUJVJEKNSA-N 50212634 CHEMBL309009 Beta-lactamase TEM 10.5 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212634&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44311630 376070543 CHEMBL309009 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558504 C[C@@]1(CSC2=NCCS2)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C11H13BrN2O3S3/c1-11(4-19-10-13-2-3-18-10)6(9(16)17)14-7(15)5(12)8(14)20-11/h5-6,8H,2-4H2,1H3,(H,16,17)/t5-,6+,8-,11+/m1/s1 SIVNUZUWNGEGKW-AGNDVQSCSA-N 50212636 CHEMBL310221 Beta-lactamase TEM 40.3 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212636&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44312261 376070545 CHEMBL310221 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558525 Cn1nnnc1SC[C@]1(C)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C10H12BrN5O3S2/c1-10(3-20-9-12-13-14-15(9)2)5(8(18)19)16-6(17)4(11)7(16)21-10/h4-5,7H,3H2,1-2H3,(H,18,19)/t4-,5+,7-,10+/m1/s1 GCUVODSDAPCLNV-ASTPYSOASA-N 50212635 CHEMBL415266 Beta-lactamase TEM 101 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212635&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44312263 376070544 CHEMBL415266 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558718 CC1(C)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C8H10BrNO3S/c1-8(2)4(7(12)13)10-5(11)3(9)6(10)14-8/h3-4,6H,1-2H3,(H,12,13)/t3-,4+,6-/m1/s1 DAVPSCAAXXVSFU-ALEPSDHESA-N 50212641 Brobactam Beta-lactamase TEM 14.3 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212641&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 65754 376070550 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558721 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 40.2 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50558997 Cn1nnnc1SC[C@@]1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H13N5O5S2/c1-10(4-21-9-11-12-13-14(9)2)7(8(17)18)15-5(16)3-6(15)22(10,19)20/h6-7H,3-4H2,1-2H3,(H,17,18)/t6-,7+,10+/m1/s1 XQHZBWNBBIUYCN-FWWHASMVSA-N 50212638 CHEMBL302512 Beta-lactamase TEM 17.3 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212638&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 14556048 376070547 CHEMBL302512 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557810 Cn1ccnc1SC[C@]1(C)S[C@@H]2[C@H](Br)C(=O)N2[C@H]1C(O)=O InChI=1S/C12H14BrN3O3S2/c1-12(5-20-11-14-3-4-15(11)2)7(10(18)19)16-8(17)6(13)9(16)21-12/h3-4,6-7,9H,5H2,1-2H3,(H,18,19)/t6-,7+,9-,12+/m1/s1 FEKDJDOMDQNFAM-GUKKNSHRSA-N 50212644 CHEMBL73450 Beta-lactamase TEM 15.3 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212644&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44312320 376070553 CHEMBL73450 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50557820 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 20.0 ChEMBL 10.7270/Q2ZW1P2T n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031069 C[C@]1(Cn2ccnn2)[C@@H](C2C(CC2=O)S1(=O)=O)C([O-])=O InChI=1S/C11H13N3O5S/c1-11(5-14-3-2-12-13-14)9(10(16)17)8-6(15)4-7(8)20(11,18)19/h2-3,7-9H,4-5H2,1H3,(H,16,17)/p-1/t7?,8?,9-,11-/m0/s1 AVPVJZPIBNHZQN-CAUGXEKISA-M 50021956 CHEMBL285387::Sodium; 3-methyl-2,2,6-trioxo-3-[1,2,3]triazol-1-ylmethyl-2lambda*6*-thia-bicyclo[3.2.0]heptane-4-carboxylate Beta-lactamase TEM 690 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021956&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 91928979 103932645 CHEMBL285387 ZINC29234607 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50031078 CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 FKENQMMABCRJMK-RITPCOANSA-N 50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US9120808, Sulbactam sodium salt Beta-lactamase TEM 10000 ChEMBL 10.1021/jm00391a032 10.7270/Q28G8JQ0 3039137 Micetich, RG; Maiti, SN; Spevak, P; Hall, TW; Yamabe, S; Ishida, N; Tanaka, M; Yamazaki, T; Nakai, A; Ogawa, K TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021954&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 0RN 7K8K,4FH2,8EBR 130313 103932643 9321 CHEMBL403 DB09324 C07770 ZINC00897244 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50770787 OC(=O)c1ccc(cc1CS)-c1ccc(F)cc1 InChI=1S/C14H11FO2S/c15-12-4-1-9(2-5-12)10-3-6-13(14(16)17)11(7-10)8-18/h1-7,18H,8H2,(H,16,17) KYTCAZSHGDLTNM-UHFFFAOYSA-N 50247459 CHEMBL4065946 Beta-lactamase TEM 32800 ChEMBL 10.1021/acs.jmedchem.7b01728 10.7270/Q2GQ716Z 29271657 Cain, R; Brem, J; Zollman, D; McDonough, MA; Johnson, RM; Spencer, J; Makena, A; Abboud, MI; Cahill, S; Lee, SY; McHugh, PJ; Schofield, CJ; Fishwick, CWG University of Leeds http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247459&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 137631517 401960934 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 50770799 OC(=O)c1ccc(cc1CS)-c1cccc(Cl)c1Cl InChI=1S/C14H10Cl2O2S/c15-12-3-1-2-10(13(12)16)8-4-5-11(14(17)18)9(6-8)7-19/h1-6,19H,7H2,(H,17,18) DRYKFHDMYZDMRX-UHFFFAOYSA-N 50247467 CHEMBL4083640 Beta-lactamase TEM 5500 ChEMBL 10.1021/acs.jmedchem.7b01728 10.7270/Q2GQ716Z 29271657 Cain, R; Brem, J; Zollman, D; McDonough, MA; Johnson, RM; Spencer, J; Makena, A; Abboud, MI; Cahill, S; Lee, SY; McHugh, PJ; Schofield, CJ; Fishwick, CWG University of Leeds http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247467&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 137645597 401960935 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147324 CC(C)CCCCCCCCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C23H38O3/c1-19(2)15-12-10-8-6-4-3-5-7-9-11-13-16-20-17-14-18-21(24)22(20)23(25)26/h14,17-19,24H,3-13,15-16H2,1-2H3,(H,25,26) INJRDKYNWRETLO-UHFFFAOYSA-N 50469656 CHEMBL34277 Beta-lactamase TEM 26700000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469656&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 44280802 433936921 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147326 CCC(C)CCCCCCCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C23H38O3/c1-3-19(2)15-12-10-8-6-4-5-7-9-11-13-16-20-17-14-18-21(24)22(20)23(25)26/h14,17-19,24H,3-13,15-16H2,1-2H3,(H,25,26) HTRXHLGQLRRIRG-UHFFFAOYSA-N 50469658 CHEMBL34634 Beta-lactamase TEM 27500000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469658&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 14262510 433936923 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147331 CCCCCCCCCCCCCCCc1cccc(O)c1 InChI=1S/C21H36O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-20-17-15-18-21(22)19-20/h15,17-19,22H,2-14,16H2,1H3 PTFIPECGHSYQNR-UHFFFAOYSA-N 50082305 3-Pentadecyl-phenol::3-pentadecyl phenol::3-pentadecylphenol::5-pentadecylphenol::CHEMBL34689 Beta-lactamase TEM >108000000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082305&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68146 103982116 CHEMBL34689 ZINC06845726 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147334 OC(=O)c1c(O)cccc1CCCCCCC\C=C/C\C=C/CC=C InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h2,4-5,7-8,15,17-18,23H,1,3,6,9-14,16H2,(H,24,25)/b5-4-,8-7- QUVGEKPNSCFQIR-UTOQUPLUSA-N 50292429 2-Hydroxy-6-pentadecyl-benzoic acid::2-Pentadecyl-6-hydroxybenzoic acid::2-hydroxy-6-((8Z,11Z)-pentadeca-8,11,14-trienyl)benzoic acid::2-hydroxy-6-pentadecylbenzoic acid::6-[8(Z),11(Z),14-pentadecatrienyl]salicylic acid::6-pentadecatrienylsalicylic acid::6-pentadecylsalicylic acid::6-{8(Z),11(Z),14-pentadecatrienyl}salicylic acid::6[8'(Z ),11'(Z ),14'-pentadecatrienyl]salicylicacid::BPH-953::CHEMBL455368::anacardic acid Beta-lactamase TEM 2330000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50292429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50292429&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9875131 104133980 CHEMBL455368 ZINC17198574 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147336 CCCCCCCCCCCCCCCc1cccc(OC)c1C(O)=O InChI=1S/C23H38O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17-20-18-16-19-21(26-2)22(20)23(24)25/h16,18-19H,3-15,17H2,1-2H3,(H,24,25) AFDSGPNKWBGVCV-UHFFFAOYSA-N 50469660 CHEMBL30915 Beta-lactamase TEM 2200000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469660&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 313885 433936925 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147338 CC\C=C/C\C=C/C\C=C/CCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C24H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h3-4,6-7,9-10,17,19-20,25H,2,5,8,11-16,18H2,1H3,(H,26,27)/b4-3-,7-6-,10-9- MBYMHCHZLAJVRK-PDBXOOCHSA-N 50469657 CHEMBL33995::SB-202742 Beta-lactamase TEM 13400000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469657&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10067772 433936922 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147340 CCCCCCCCCCCCCCCc1cccc(O)c1O InChI=1S/C21H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(22)21(19)23/h15,17-18,22-23H,2-14,16H2,1H3 DQTMTQZSOJMZSF-UHFFFAOYSA-N 50469662 CHEBI:59111::CHEMBL8087 Beta-lactamase TEM 2147483647 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469662&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 68118 433936927 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147342 CCCCCCCCCCc1cccc(O)c1O InChI=1S/C16H26O2/c1-2-3-4-5-6-7-8-9-11-14-12-10-13-15(17)16(14)18/h10,12-13,17-18H,2-9,11H2,1H3 RIJPREMBVOLUIU-UHFFFAOYSA-N 50469663 CHEMBL33019 Beta-lactamase TEM 199000000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469663&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 13848091 433936928 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147345 CCCCCCCCCCc1ccccc1C(O)=O InChI=1S/C17H26O2/c1-2-3-4-5-6-7-8-9-12-15-13-10-11-14-16(15)17(18)19/h10-11,13-14H,2-9,12H2,1H3,(H,18,19) RGRRXKZHELYJHJ-UHFFFAOYSA-N 50469659 2-Decyl-Benzoic Acid::CHEMBL284924 Beta-lactamase TEM 68600000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469659&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 21698838 433936924 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147354 CCCCCCCCCCc1cccc(O)c1 InChI=1S/C16H26O/c1-2-3-4-5-6-7-8-9-11-15-12-10-13-16(17)14-15/h10,12-14,17H,2-9,11H2,1H3 HRMIBYZWBMSUHC-UHFFFAOYSA-N 50469664 3-Decyl-Phenol::CHEMBL33202 Beta-lactamase TEM 8100000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469664&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 20034951 433936929 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147356 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 145000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147359 CCCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C15H22O3/c1-2-3-4-5-6-7-9-12-10-8-11-13(16)14(12)15(17)18/h8,10-11,16H,2-7,9H2,1H3,(H,17,18) URXCFPXNCPBEJA-UHFFFAOYSA-N 50469666 6-Octylsalicylic Acid::CHEMBL33379 Beta-lactamase TEM 207000000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469666&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 14298684 433936931 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147360 CCCCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C24H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h17,19-20,25H,2-16,18H2,1H3,(H,26,27) XUSNORMUTPYOKW-UHFFFAOYSA-N 50469665 CHEMBL30914 Beta-lactamase TEM 5040000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469665&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 14274508 433936930 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147361 CCCCCCCCCCc1cccc(OC)c1C(O)=O InChI=1S/C18H28O3/c1-3-4-5-6-7-8-9-10-12-15-13-11-14-16(21-2)17(15)18(19)20/h11,13-14H,3-10,12H2,1-2H3,(H,19,20) XZYAYMRZTRZSTF-UHFFFAOYSA-N 50469661 CHEMBL30870 Beta-lactamase TEM 184000000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469661&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 20757679 433936926 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51147395 CCCCCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C17H26O3/c1-2-3-4-5-6-7-8-9-11-14-12-10-13-15(18)16(14)17(19)20/h10,12-13,18H,2-9,11H2,1H3,(H,19,20) ZQDLBPGHPAIXKL-UHFFFAOYSA-N 50469667 6-Decylsalicylic Acid::CHEMBL416038 Beta-lactamase TEM 43100000 ChEMBL 10.1016/S0960-894X(01)80506-0 10.7270/Q21V5HPM n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469667&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 9795646 433936932 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51167175 CC\C=C/C\C=C/C\C=C/CCCCCCCc1cccc(O)c1C(O)=O InChI=1S/C24H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-21-19-17-20-22(25)23(21)24(26)27/h3-4,6-7,9-10,17,19-20,25H,2,5,8,11-16,18H2,1H3,(H,26,27)/b4-3-,7-6-,10-9- MBYMHCHZLAJVRK-PDBXOOCHSA-N 50469657 CHEMBL33995::SB-202742 Beta-lactamase TEM 13400 ChEMBL 10.1021/np50107a016 10.7270/Q2SQ935W 8064298 Coates, NJ; Gilpin, ML; Gwynn, MN; Lewis, DE; Milner, PH; Spear, SR; Tyler, JW SmithKline Beecham Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469657&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 10067772 433936922 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51167177 OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1-/t6-,7-/m1/s1 HZZVJAQRINQKSD-PBFISZAISA-N 50021959 CHEMBL777::MM 14151::US9120808, Clavulanic acid potassium salt::antibiotic MM 14151::clavulanic acid Beta-lactamase TEM 145 ChEMBL 10.1021/np50107a016 10.7270/Q2SQ935W 8064298 Coates, NJ; Gilpin, ML; Gwynn, MN; Lewis, DE; Milner, PH; Spear, SR; Tyler, JW SmithKline Beecham Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021959&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search J01 6NVU,2XH9,2XF3,2XFS,6PQ8,2JAP 5280980 103932648 48947 CHEMBL777 DB00766 C06662 ZINC03830569 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 867652 CC(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O InChI=1S/C9H14N4O7S/c1-5(14)10-11-8(15)7-3-2-6-4-12(7)9(16)13(6)20-21(17,18)19/h6-7H,2-4H2,1H3,(H,10,14)(H,11,15)(H,17,18,19)/t6-,7+/m1/s1 WVZOCYGRXONJLX-RQJHMYQMSA-N 428643 US10544146, Ex. 40 Beta-lactamase TEM 52.0 US Patent 10.7270/Q2KS6TX4 aid1804119 US10544146 Maiti, SN; Nguyen, D; Khan, J; Ling, R FEDORA PHARMACEUTICALS INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=428643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=428643&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 71682990 434318222 C02000 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51265229 OB(O)c1sc2ccccc2c1\C=C\C(O)=O InChI=1S/C11H9BO4S/c13-10(14)6-5-8-7-3-1-2-4-9(7)17-11(8)12(15)16/h1-6,15-16H,(H,13,14)/b6-5+ IYRVQPJBSDCZBO-AATRIKPKSA-N 50516761 CHEMBL3286879 Beta-lactamase TEM 40 ChEMBL 10.1016/j.ejmech.2019.06.092 10.7270/Q28055ZM 31288128 Fernandes, GFS; Denny, WA; Dos Santos, JL S£o Paulo State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516761&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 2GK 4LEN 90680707 440725343 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51233835 NCc1ccc(cc1)C(=O)N[C@H]1Cc2cccc(C(O)=O)c2OB1O InChI=1S/C17H17BN2O5/c19-9-10-4-6-11(7-5-10)16(21)20-14-8-12-2-1-3-13(17(22)23)15(12)25-18(14)24/h1-7,14,24H,8-9,19H2,(H,20,21)(H,22,23)/t14-/m0/s1 IYRRPBDRRHYOLY-AWEZNQCLSA-N 50505403 CHEMBL4533632 Beta-lactamase TEM 3.0 ChEMBL 10.1021/acs.jmedchem.9b00911 10.7270/Q2P272DC 31454231 Krajnc, A; Brem, J; Hinchliffe, P; Calvopiña, K; Panduwawala, TD; Lang, PA; Kamps, JJAG; Tyrrell, JM; Widlake, E; Saward, BG; Walsh, TR; Spencer, J; Schofield, CJ University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505403&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 142473761 440713988 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270503 CC(C)C[C@@H](NC(=O)[C@H](C)CS)B(O)O InChI=1S/C9H20BNO3S/c1-6(2)4-8(10(13)14)11-9(12)7(3)5-15/h6-8,13-15H,4-5H2,1-3H3,(H,11,12)/t7-,8-/m1/s1 SITGXABKUNMKGV-HTQZYQBOSA-N 50518877 CHEMBL4546207 Beta-lactamase TEM 70550 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518877&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155553532 440727459 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270504 C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1 FAKRSMQSSFJEIM-RQJHMYQMSA-N 21642 (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid::CHEMBL1560::Capozide::Captopril::Lopirin::SQ 14,225::SQ14534::US11491146, Compound L-Captopril Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21642&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search X8Z 4C1D,4C1F,4C1H,4DPR,3LUS,6V61,5ZIO,4EXS,2X8Z,6U10,5AYA,4PQA,4C2P,1J37 44093 49700752 3380 CHEMBL1560 DB01197 5158 ZINC00057001 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270505 COc1ccc(C[C@H](NC(=O)[C@H](C)CS)B(O)O)cc1 InChI=1S/C13H20BNO4S/c1-9(8-20)13(16)15-12(14(17)18)7-10-3-5-11(19-2)6-4-10/h3-6,9,12,17-18,20H,7-8H2,1-2H3,(H,15,16)/t9-,12+/m1/s1 PQADIRATANJZTA-SKDRFNHKSA-N 50518878 CHEMBL4464588 Beta-lactamase TEM 3360 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518878&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155530470 440727460 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270506 C[C@H](CS)C(=O)N[C@H](B(O)O)c1ccc2ccccc2c1 InChI=1S/C15H18BNO3S/c1-10(9-21)15(18)17-14(16(19)20)13-7-6-11-4-2-3-5-12(11)8-13/h2-8,10,14,19-21H,9H2,1H3,(H,17,18)/t10-,14+/m1/s1 IQMDPFNHBHCYOR-YGRLFVJLSA-N 50518879 CHEMBL4450911 Beta-lactamase TEM 2030 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518879&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155522169 440727461 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270507 CC(C)[C@@H](NC(=O)[C@H](C)CS)B(O)O InChI=1S/C8H18BNO3S/c1-5(2)7(9(12)13)10-8(11)6(3)4-14/h5-7,12-14H,4H2,1-3H3,(H,10,11)/t6-,7-/m1/s1 LKWZXMPOAPIRSL-RNFRBKRXSA-N 50518880 CHEMBL4438924 Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518880&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155513518 440727462 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270508 OB(O)[C@@H](Cc1coc2ccccc12)NC(=O)CCS InChI=1S/C13H16BNO4S/c16-13(5-6-20)15-12(14(17)18)7-9-8-19-11-4-2-1-3-10(9)11/h1-4,8,12,17-18,20H,5-7H2,(H,15,16)/t12-/m1/s1 KODSQKNWIFWKEO-GFCCVEGCSA-N 50518881 CHEMBL4455145 Beta-lactamase TEM 35740 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518881&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155524678 440727463 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270509 OB(O)[C@@H](Cc1coc2ccccc12)NC(=O)CS InChI=1S/C12H14BNO4S/c15-12(7-19)14-11(13(16)17)5-8-6-18-10-4-2-1-3-9(8)10/h1-4,6,11,16-17,19H,5,7H2,(H,14,15)/t11-/m1/s1 GJIFDHQPJZOHPL-LLVKDONJSA-N 50518882 CHEMBL4471138 Beta-lactamase TEM 6840 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518882&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155534856 440727464 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270510 CCCC(=O)NCB(O)O InChI=1S/C5H12BNO3/c1-2-3-5(8)7-4-6(9)10/h9-10H,2-4H2,1H3,(H,7,8) WYUKBCPRJKKWPG-UHFFFAOYSA-N 50518883 CHEMBL4577981 Beta-lactamase TEM 100280 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518883&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155564582 440727465 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270511 CCC(=O)NCB(O)O InChI=1S/C4H10BNO3/c1-2-4(7)6-3-5(8)9/h8-9H,2-3H2,1H3,(H,6,7) WAWWIDFTJZZHNC-UHFFFAOYSA-N 50518884 CHEMBL4588584 Beta-lactamase TEM 36260 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518884&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 11607917 440727466 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270512 C[C@]1(Cn2ccnn2)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 50053173 (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda 6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide::3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::CHEMBL404::CL-298741::TAZOBACTAM::US9120808, Tazobactam sodium salt::US9676777, TAZ::YTR-830H::Zosyn Beta-lactamase TEM 190 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053173&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search TAZ 1VM1 123630 103949887 9421 CHEMBL404 DB01606 C07771 ZINC03787060 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270513 OB(O)[C@H](Cc1ccccc1)NC(=O)C(CS)Cc1ccccc1 InChI=1S/C18H22BNO3S/c21-18(16(13-24)11-14-7-3-1-4-8-14)20-17(19(22)23)12-15-9-5-2-6-10-15/h1-10,16-17,22-24H,11-13H2,(H,20,21)/t16?,17-/m0/s1 PRRLVNGPQFZIHL-DJNXLDHESA-N 50518885 CHEMBL4451026 Beta-lactamase TEM 114070 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518885&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155522350 440727467 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270514 OB(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CS)N1C(=O)c2ccccc2C1=O InChI=1S/C19H19BN2O5S/c23-17(21-16(20(26)27)10-12-6-2-1-3-7-12)15(11-28)22-18(24)13-8-4-5-9-14(13)19(22)25/h1-9,15-16,26-28H,10-11H2,(H,21,23)/t15-,16+/m1/s1 OAVOXSKIFPDVFR-CVEARBPZSA-N 50518886 CHEMBL4471673 Beta-lactamase TEM 32820 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518886&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155535317 440727468 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270515 OB(O)[C@H](Cc1ccccc1)NC(=O)CCS InChI=1S/C11H16BNO3S/c14-11(6-7-17)13-10(12(15)16)8-9-4-2-1-3-5-9/h1-5,10,15-17H,6-8H2,(H,13,14)/t10-/m0/s1 YJAUBKVHBZDGEC-JTQLQIEISA-N 50518887 CHEMBL4527309 Beta-lactamase TEM 15840 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518887&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155544369 440727469 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270516 CCC(=O)N[C@@H](Cc1ccccc1)B(O)O InChI=1S/C11H16BNO3/c1-2-11(14)13-10(12(15)16)8-9-6-4-3-5-7-9/h3-7,10,15-16H,2,8H2,1H3,(H,13,14)/t10-/m0/s1 GOSWZPMWKSLXDI-JTQLQIEISA-N 50518888 CHEMBL4466256 Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518888&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155531699 440727470 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270517 C[C@H](CS)C(=O)N[C@@H](Cc1ccc(F)cc1)B(O)O InChI=1S/C12H17BFNO3S/c1-8(7-19)12(16)15-11(13(17)18)6-9-2-4-10(14)5-3-9/h2-5,8,11,17-19H,6-7H2,1H3,(H,15,16)/t8-,11+/m1/s1 SYBMBVLEALMERL-KCJUWKMLSA-N 50518889 CHEMBL4560468 Beta-lactamase TEM 4160 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518889&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155558613 440727471 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270518 C[C@H](CS)C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O InChI=1S/C14H18BNO4S/c1-9(8-21)14(17)16-13(15(18)19)6-10-7-20-12-5-3-2-4-11(10)12/h2-5,7,9,13,18-19,21H,6,8H2,1H3,(H,16,17)/t9-,13+/m1/s1 RHFFZKGRUWBIGC-RNCFNFMXSA-N 50518890 CHEMBL4439726 Beta-lactamase TEM 10770 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518890&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155514065 440727472 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270519 C[C@H](CS)C(=O)N[C@H](Cc1coc2ccccc12)B(O)O InChI=1S/C14H18BNO4S/c1-9(8-21)14(17)16-13(15(18)19)6-10-7-20-12-5-3-2-4-11(10)12/h2-5,7,9,13,18-19,21H,6,8H2,1H3,(H,16,17)/t9-,13-/m1/s1 RHFFZKGRUWBIGC-NOZJJQNGSA-N 50518891 CHEMBL4460127 Beta-lactamase TEM 32700 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518891&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BY0 6JN6 138455174 440727473 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270520 C[C@H](CS)C(=O)N[C@H](B(O)O)c1ccc(F)cc1 InChI=1S/C11H15BFNO3S/c1-7(6-18)11(15)14-10(12(16)17)8-2-4-9(13)5-3-8/h2-5,7,10,16-18H,6H2,1H3,(H,14,15)/t7-,10+/m1/s1 CDDJMEDWZMPIRW-XCBNKYQSSA-N 50518892 CHEMBL4453017 Beta-lactamase TEM 14170 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518892&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BX9 6JN4 138753149 440727474 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270521 C[C@H](CS)C(=O)N[C@@H](B(O)O)c1ccc(F)cc1 InChI=1S/C11H15BFNO3S/c1-7(6-18)11(15)14-10(12(16)17)8-2-4-9(13)5-3-8/h2-5,7,10,16-18H,6H2,1H3,(H,14,15)/t7-,10-/m1/s1 CDDJMEDWZMPIRW-GMSGAONNSA-N 50518893 CHEMBL4545947 Beta-lactamase TEM 67940 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518893&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BXU 6JN5 138455171 440727475 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270522 C[C@H](CS)C(=O)N[C@@H](B(O)O)c1ccc2ccccc2c1 InChI=1S/C15H18BNO3S/c1-10(9-21)15(18)17-14(16(19)20)13-7-6-11-4-2-3-5-12(11)8-13/h2-8,10,14,19-21H,9H2,1H3,(H,17,18)/t10-,14-/m1/s1 IQMDPFNHBHCYOR-QMTHXVAHSA-N 50518894 CHEMBL4444926 Beta-lactamase TEM 215720 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518894&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155517363 440727476 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270523 C[C@H](CS)C(=O)N[C@@H](Cc1ccccc1)B(O)O InChI=1S/C12H18BNO3S/c1-9(8-18)12(15)14-11(13(16)17)7-10-5-3-2-4-6-10/h2-6,9,11,16-18H,7-8H2,1H3,(H,14,15)/t9-,11+/m1/s1 FYDJFEUAPCQUQY-KOLCDFICSA-N 50518895 CHEMBL4454286 Beta-lactamase TEM 15410 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518895&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BX6 6JN3 138455168 440727477 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270524 C[C@H](CS)C(=O)N[C@@H](B(O)O)c1ccccc1 InChI=1S/C11H16BNO3S/c1-8(7-17)11(14)13-10(12(15)16)9-5-3-2-4-6-9/h2-6,8,10,15-17H,7H2,1H3,(H,13,14)/t8-,10-/m1/s1 JSHOMWZZXGBSLY-PSASIEDQSA-N 50518896 CHEMBL4517893 Beta-lactamase TEM 68590 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518896&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155541103 440727478 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270525 C[C@H](CS)C(=O)NCB(O)O InChI=1S/C5H12BNO3S/c1-4(2-11)5(8)7-3-6(9)10/h4,9-11H,2-3H2,1H3,(H,7,8)/t4-/m1/s1 HXSZVYICUWXMQS-SCSAIBSYSA-N 50518897 CHEMBL4450628 Beta-lactamase TEM 40970 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518897&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BHU 6J8Q,6J8R 138455166 440727479 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270526 C[C@H](CS)C(=O)NCC(O)=O InChI=1S/C6H11NO3S/c1-4(3-11)6(10)7-2-5(8)9/h4,11H,2-3H2,1H3,(H,7,10)(H,8,9)/t4-/m1/s1 VXOCIBBWDLKODX-SCSAIBSYSA-N 50518898 CHEMBL4546893 Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518898&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 29982928 440727480 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270527 OB(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CS)NCc1ccccc1 InChI=1S/C18H23BN2O3S/c22-18(16(13-25)20-12-15-9-5-2-6-10-15)21-17(19(23)24)11-14-7-3-1-4-8-14/h1-10,16-17,20,23-25H,11-13H2,(H,21,22)/t16-,17+/m1/s1 BUZSQQWFRAWZOA-SJORKVTESA-N 50518899 CHEMBL4460555 Beta-lactamase TEM 28020 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518899&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155527828 440727481 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270528 C[C@H](CS)C(=O)N[C@H](Cc1ccc(F)cc1)B(O)O InChI=1S/C12H17BFNO3S/c1-8(7-19)12(16)15-11(13(17)18)6-9-2-4-10(14)5-3-9/h2-5,8,11,17-19H,6-7H2,1H3,(H,15,16)/t8-,11-/m1/s1 SYBMBVLEALMERL-LDYMZIIASA-N 50518900 CHEMBL4545274 Beta-lactamase TEM 178980 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518900&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155552801 440727482 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270529 C[C@H](CS)C(=O)N[C@H](B(O)O)c1ccccc1 InChI=1S/C11H16BNO3S/c1-8(7-17)11(14)13-10(12(15)16)9-5-3-2-4-6-9/h2-6,8,10,15-17H,7H2,1H3,(H,13,14)/t8-,10+/m1/s1 JSHOMWZZXGBSLY-SCZZXKLOSA-N 50518901 CHEMBL4468952 Beta-lactamase TEM 6370 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518901&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155533176 440727483 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270530 C[C@H](CS)C(=O)N[C@H](B(O)O)c1ccc(C)cc1 InChI=1S/C12H18BNO3S/c1-8-3-5-10(6-4-8)11(13(16)17)14-12(15)9(2)7-18/h3-6,9,11,16-18H,7H2,1-2H3,(H,14,15)/t9-,11+/m1/s1 JPGSBBIDSWFANO-KOLCDFICSA-N 50518902 CHEMBL4458011 Beta-lactamase TEM 2410 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518902&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155525928 440727484 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270531 CC(C)[C@H](NC(=O)[C@H](C)CS)B(O)O InChI=1S/C8H18BNO3S/c1-5(2)7(9(12)13)10-8(11)6(3)4-14/h5-7,12-14H,4H2,1-3H3,(H,10,11)/t6-,7+/m1/s1 LKWZXMPOAPIRSL-RQJHMYQMSA-N 50518903 CHEMBL4445648 Beta-lactamase TEM 165780 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518903&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155518013 440727485 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270532 CCCC(=O)N[C@@H](Cc1ccccc1)B(O)O InChI=1S/C12H18BNO3/c1-2-6-12(15)14-11(13(16)17)9-10-7-4-3-5-8-10/h3-5,7-8,11,16-17H,2,6,9H2,1H3,(H,14,15)/t11-/m0/s1 AUSSHJQGUQTRPJ-NSHDSACASA-N 50518904 CHEMBL4544829 Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518904&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 147015730 440727486 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270533 CC(C)C[C@H](NC(=O)[C@H](C)CS)B(O)O InChI=1S/C9H20BNO3S/c1-6(2)4-8(10(13)14)11-9(12)7(3)5-15/h6-8,13-15H,4-5H2,1-3H3,(H,11,12)/t7-,8+/m1/s1 SITGXABKUNMKGV-SFYZADRCSA-N 50518905 CHEMBL4469059 Beta-lactamase TEM 170700 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518905&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155533700 440727487 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270534 OB(O)[C@H](Cc1ccccc1)NC(=O)CS InChI=1S/C10H14BNO3S/c13-10(7-16)12-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9,14-16H,6-7H2,(H,12,13)/t9-/m0/s1 TVNFGLNUEGQYOF-VIFPVBQESA-N 50518906 CHEMBL4444728 Beta-lactamase TEM 18730 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518906&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155517666 440727488 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270535 C[C@H](CS)C(=O)N[C@@H](B(O)O)c1ccc(C)cc1 InChI=1S/C12H18BNO3S/c1-8-3-5-10(6-4-8)11(13(16)17)14-12(15)9(2)7-18/h3-6,9,11,16-18H,7H2,1-2H3,(H,14,15)/t9-,11-/m1/s1 JPGSBBIDSWFANO-MWLCHTKSSA-N 50518907 CHEMBL4472399 Beta-lactamase TEM 13500 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518907&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155535451 440727489 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270536 COc1ccc(C[C@@H](NC(=O)[C@H](C)CS)B(O)O)cc1 InChI=1S/C13H20BNO4S/c1-9(8-20)13(16)15-12(14(17)18)7-10-3-5-11(19-2)6-4-10/h3-6,9,12,17-18,20H,7-8H2,1-2H3,(H,15,16)/t9-,12-/m1/s1 PQADIRATANJZTA-BXKDBHETSA-N 50518908 CHEMBL4543432 Beta-lactamase TEM 80720 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518908&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155510617 440727490 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51270537 C[C@H](CS)C(=O)N[C@H](Cc1ccccc1)B(O)O InChI=1S/C12H18BNO3S/c1-9(8-18)12(15)14-11(13(16)17)7-10-5-3-2-4-6-10/h2-6,9,11,16-18H,7-8H2,1H3,(H,14,15)/t9-,11-/m1/s1 FYDJFEUAPCQUQY-MWLCHTKSSA-N 50518909 CHEMBL4464521 Beta-lactamase TEM >300000 ChEMBL 10.1021/acs.jmedchem.9b00735 10.7270/Q22R3W2M 31269398 Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50518909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50518909&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155530513 440727491 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306160 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2 BYBLEWFAAKGYCD-UHFFFAOYSA-N 31772 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid::Brentan::CHEMBL91::Dactarin::Miconazole::US9138393, Miconazole Nitrate::US9144538, Miconazole Nitrate::cid_4189 Beta-lactamase TEM 125000 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31772&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search X89 3OZU 4189 85240398 6923 CHEMBL91 DB01110 2449 C08070 ZINC00896740 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306161 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31 InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 50238741 CHEBI:31638::Faslodex::Fulvestrant::ICI-182780::ZD-9238 Beta-lactamase TEM 55900 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238741&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22273644 85716166 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306162 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2 BYBLEWFAAKGYCD-UHFFFAOYSA-N 31772 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid::Brentan::CHEMBL91::Dactarin::Miconazole::US9138393, Miconazole Nitrate::US9144538, Miconazole Nitrate::cid_4189 Beta-lactamase TEM 125000 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31772&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search X89 3OZU 4189 85240398 6923 CHEMBL91 DB01110 2449 C08070 ZINC00896740 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306163 Oc1c(I)cc(cc1I)C1(OC(=O)c2ccccc12)c1cc(I)c(O)c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)17(13)25)20(10-7-15(23)18(26)16(24)8-10)12-4-2-1-3-11(12)19(27)28-20/h1-8,25-26H FWQKRBDABCRWKV-UHFFFAOYSA-N 50530710 IODOPHTHALEIN Beta-lactamase TEM 3400 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50530710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50530710&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 67846 440739292 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306164 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31 InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 50238741 CHEBI:31638::Faslodex::Fulvestrant::ICI-182780::ZD-9238 Beta-lactamase TEM 55900 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50238741&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 22273644 85716166 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51306165 Oc1c(I)cc(cc1I)C1(OC(=O)c2ccccc12)c1cc(I)c(O)c(I)c1 InChI=1S/C20H10I4O4/c21-13-5-9(6-14(22)17(13)25)20(10-7-15(23)18(26)16(24)8-10)12-4-2-1-3-11(12)19(27)28-20/h1-8,25-26H FWQKRBDABCRWKV-UHFFFAOYSA-N 50530710 IODOPHTHALEIN Beta-lactamase TEM 3400 ChEMBL 10.1021/acs.jmedchem.9b01019 10.7270/Q2HX1H4Z 31589047 Torosyan, H; Shoichet, BK University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50530710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50530710&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 67846 440739292 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51292566 CC(=O)N[C@@H](Cc1cccc(c1)C(O)=O)B(O)O InChI=1S/C11H14BNO5/c1-7(14)13-10(12(17)18)6-8-3-2-4-9(5-8)11(15)16/h2-5,10,17-18H,6H2,1H3,(H,13,14)(H,15,16)/t10-/m0/s1 OBZSRKUYUGJGIM-JTQLQIEISA-N 50526862 CHEMBL1231367 Beta-lactamase TEM 110 ChEMBL 10.1021/acs.jmedchem.9b01279 10.7270/Q27P92V4 31663735 González-Bello, C; Rodríguez, D; Pernas, M; Rodríguez, Á; Colchón, E Universidade de Santiago de Compostela http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526862&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search BJI 1ERM 5287795 440735444 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965054 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C10H12FN3O5/c1-4-2-5-3-13(6(4)8(12)15)10(18)14(5)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5?,6-,7+/m0/s1 HBJXCJGYADJSFE-BOJSHJERSA-N 466964 (2S)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}(fluoro)ethanoic acid lithium salt::US10800778, Example 3 Beta-lactamase TEM 19.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466964&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922438 441576657 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965057 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2O[C@H](F)C(O)=O InChI=1S/C10H12FN3O5/c1-4-2-5-3-13(6(4)8(12)15)10(18)14(5)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5?,6-,7-/m0/s1 HBJXCJGYADJSFE-BYRXKDITSA-N 466965 (2R)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}(fluoro)ethanoic acid lithium salt::US10800778, Example 4 Beta-lactamase TEM 1.35 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466965&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922439 441576658 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965060 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2OC(F)C(O)=O InChI=1S/C10H12FN3O5/c1-4-2-5-3-13(6(4)8(12)15)10(18)14(5)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5?,6-,7?/m0/s1 HBJXCJGYADJSFE-HUDPQJTASA-N 466966 US10800778, Example 5::{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}(fluoro)acetic acid lithium salt (mixture of diastereomers) Beta-lactamase TEM 4.40 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466966&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922440 441576659 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965063 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2OC(F)(F)C(O)=O InChI=1S/C10H11F2N3O5/c1-4-2-5-3-14(6(4)7(13)16)9(19)15(5)20-10(11,12)8(17)18/h2,5-6H,3H2,1H3,(H2,13,16)(H,17,18)/t5?,6-/m0/s1 QYPIGCMIMCHYCS-GDVGLLTNSA-N 466967 US10800778, Example 8::{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}(difluoro)acetic acid lithium salt Beta-lactamase TEM 1.50 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466967&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922441 441576660 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965066 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2OCC(O)=O InChI=1S/C10H13N3O5/c1-5-2-6-3-12(8(5)9(11)16)10(17)13(6)18-4-7(14)15/h2,6,8H,3-4H2,1H3,(H2,11,16)(H,14,15)/t6?,8-/m0/s1 RUDGJWAKUPBPKU-XDKWHASVSA-N 466968 US10800778, Example 10::{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}acetic acid lithium salt Beta-lactamase TEM 430 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466968&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922442 441576661 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965069 CC1=C[C@@H]2CN([C@@H]1C(N)=O)C(=O)N2OC(C)(F)C(O)=O InChI=1S/C11H14FN3O5/c1-5-3-6-4-14(7(5)8(13)16)10(19)15(6)20-11(2,12)9(17)18/h3,6-7H,4H2,1-2H3,(H2,13,16)(H,17,18)/t6?,7-,11?/m0/s1 SOQURWNDDXDSTI-KKOGVWMFSA-N 466969 2-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy}-2-fluoropropanoic acid lithium salt (mixture of diastereomers)::US10800778, Example 11 Beta-lactamase TEM 230 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466969&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922443 441576662 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965072 CC(=O)NNC(=O)[C@H]1N2C[C@@H](C=C1C)N(OC(F)C(O)=O)C2=O InChI=1S/C12H15FN4O6/c1-5-3-7-4-16(8(5)10(19)15-14-6(2)18)12(22)17(7)23-9(13)11(20)21/h3,7-9H,4H2,1-2H3,(H,14,18)(H,15,19)(H,20,21)/t7?,8-,9?/m0/s1 BLOSWWBHNLGJRP-MGURRDGZSA-N 466970 2-(((2S,5R)-2-(2-acetylhydrazinecarbonyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 27 Beta-lactamase TEM 47.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466970&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922444 441576663 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965075 CC1=C[C@@H]2CN([C@@H]1C(=O)NCc1cnccn1)C(=O)N2OC(F)C(O)=O InChI=1S/C15H16FN5O5/c1-8-4-10-7-20(15(25)21(10)26-12(16)14(23)24)11(8)13(22)19-6-9-5-17-2-3-18-9/h2-5,10-12H,6-7H2,1H3,(H,19,22)(H,23,24)/t10?,11-,12?/m0/s1 SFPTWFMBZJRMKD-CXQJBGSLSA-N 466971 2-fluoro-2-(((2S,5R)-3-methyl-7-oxo-2-((pyrazin-2-ylmethyl)carbamoyl)-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)acetic acid lithium salt::US10800778, Example 30 Beta-lactamase TEM 81.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466971&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922445 441576664 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965078 CC1=C[C@H](N2C[C@@H]1N(O[C@H](F)C(O)=O)C2=O)C(N)=O InChI=1S/C10H12FN3O5/c1-4-2-5(8(12)15)13-3-6(4)14(10(13)18)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5-,6?,7-/m0/s1 CZCMDCKIUIXEQC-LOJRBXKRSA-N 466972 (2R)-2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 33 Beta-lactamase TEM 3.20 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466972&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922446 441576665 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965081 CC1=C[C@H](N2C[C@@H]1N(O[C@@H](F)C(O)=O)C2=O)C(N)=O InChI=1S/C10H12FN3O5/c1-4-2-5(8(12)15)13-3-6(4)14(10(13)18)19-7(11)9(16)17/h2,5-7H,3H2,1H3,(H2,12,15)(H,16,17)/t5-,6?,7+/m0/s1 CZCMDCKIUIXEQC-REJBHVJUSA-N 466973 (2S)-2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 34 Beta-lactamase TEM 26.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466973&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922447 441576666 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965084 NC(=O)[C@H]1N2C[C@@H](C=C1C1CC1)N(O[C@H](F)C(O)=O)C2=O InChI=1S/C12H14FN3O5/c13-9(11(18)19)21-16-6-3-7(5-1-2-5)8(10(14)17)15(4-6)12(16)20/h3,5-6,8-9H,1-2,4H2,(H2,14,17)(H,18,19)/t6?,8-,9-/m0/s1 ZEICLMMMMGQHIK-KBNZOQNLSA-N 466974 (2R)-2-(((2S,5R)-2-carbamoyl-3-cyclopropyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 41 Beta-lactamase TEM 3.50 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466974&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922448 441576667 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965087 NC(=O)[C@H]1N2C[C@@H](C=C1C1CC1)N(O[C@@H](F)C(O)=O)C2=O InChI=1S/C12H14FN3O5/c13-9(11(18)19)21-16-6-3-7(5-1-2-5)8(10(14)17)15(4-6)12(16)20/h3,5-6,8-9H,1-2,4H2,(H2,14,17)(H,18,19)/t6?,8-,9+/m0/s1 ZEICLMMMMGQHIK-TWSLBNPLSA-N 466975 (2R)-2-(((2S,5R)-2-carbamoyl-3-cyclopropyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 42 Beta-lactamase TEM 24.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466975&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922449 441576668 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965090 CC1=C[C@@H]2CN([C@@H]1c1nnc(o1)C(N)=O)C(=O)N2OC(F)C(O)=O InChI=1S/C12H12FN5O6/c1-4-2-5-3-17(12(22)18(5)24-7(13)11(20)21)6(4)9-15-16-10(23-9)8(14)19/h2,5-7H,3H2,1H3,(H2,14,19)(H,20,21)/t5?,6-,7?/m0/s1 YHANUKIZKPOWPW-HUDPQJTASA-N 466977 2-[[(2S,5R)-2-(5-carbamoyl-1,3,4-oxadiazol-2-yl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]-2-fluoro-acetic acid lithium salt::US10800778, Example 55 Beta-lactamase TEM 24.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466977&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922450 441576670 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965093 CC1=C[C@@H]2CN([C@@H]1C(=O)NOCCS(N)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C12H17FN4O8S/c1-6-4-7-5-16(12(21)17(7)25-9(13)11(19)20)8(6)10(18)15-24-2-3-26(14,22)23/h4,7-9H,2-3,5H2,1H3,(H,15,18)(H,19,20)(H2,14,22,23)/t7?,8-,9+/m0/s1 WYRIPYFYOUAORN-SXNZSPLWSA-N 466978 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(2-sulfamoylethoxycarbamoyl)-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 56 Beta-lactamase TEM 93.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466978&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922451 441576671 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965096 CC1=C[C@@H]2CN([C@@H]1C(=O)NCCS(N)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C12H17FN4O7S/c1-6-4-7-5-16(12(21)17(7)24-9(13)11(19)20)8(6)10(18)15-2-3-25(14,22)23/h4,7-9H,2-3,5H2,1H3,(H,15,18)(H,19,20)(H2,14,22,23)/t7?,8-,9+/m0/s1 YFHXDSIOXRFREU-SXNZSPLWSA-N 466979 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(2-sulfamoylethylcarbamoyl)-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 57 Beta-lactamase TEM 57.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466979&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922452 441576672 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965099 CC1=C[C@@H]2CN([C@@H]1C(=O)NOC[C@@H]1CCCN1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C15H21FN4O6/c1-8-5-10-6-19(15(24)20(10)26-12(16)14(22)23)11(8)13(21)18-25-7-9-3-2-4-17-9/h5,9-12,17H,2-4,6-7H2,1H3,(H,18,21)(H,22,23)/t9-,10?,11-,12+/m0/s1 SWIHLLNXGOJYRM-YEJSDXFRSA-N 466980 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[[(2S)-pyrrolidin-2-yl]methoxycarbamoyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid TFA salt::US10800778, Example 62 Beta-lactamase TEM 210 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466980&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922453 441576673 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965102 CC1=C[C@@H]2CN([C@@H]1C(=O)NOC[C@@H]1CC(F)(F)CN1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C15H19F3N4O6/c1-7-2-9-4-21(14(26)22(9)28-11(16)13(24)25)10(7)12(23)20-27-5-8-3-15(17,18)6-19-8/h2,8-11,19H,3-6H2,1H3,(H,20,23)(H,24,25)/t8-,9?,10-,11+/m0/s1 QEEMJZXDEIFDDR-OFLUOSHYSA-N 466981 (2S)-2-(((2S,5R)-2-((((S)-4,4-difluoropyrrolidin-2-yl)methoxy)carbamoyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid TFA salt::US10800778, Example 63 Beta-lactamase TEM 110 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466981&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922454 441576674 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965105 CC1=C[C@@H]2CN([C@@H]1C(=O)NC1COC1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C13H16FN3O6/c1-6-2-8-3-16(9(6)11(18)15-7-4-22-5-7)13(21)17(8)23-10(14)12(19)20/h2,7-10H,3-5H2,1H3,(H,15,18)(H,19,20)/t8?,9-,10+/m0/s1 XXDOEORVWMNHIY-CBMCFHRWSA-N 466982 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-2-(oxetan-3-ylcarbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 66 Beta-lactamase TEM 660 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466982&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922455 441576675 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965108 CC1=C[C@@H]2CN([C@@H]1C(=O)NCCNS(C)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C13H19FN4O7S/c1-7-5-8-6-17(13(22)18(8)25-10(14)12(20)21)9(7)11(19)15-3-4-16-26(2,23)24/h5,8-10,16H,3-4,6H2,1-2H3,(H,15,19)(H,20,21)/t8?,9-,10+/m0/s1 VRAFEQHIWHNGLC-CBMCFHRWSA-N 466983 (2S)-2-fluoro-2-[[(2S,5R)-2-[2-(methanesulfonamido)ethylcarbamoyl]-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 67 Beta-lactamase TEM 64.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466983&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922456 441576676 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965111 CC1=C[C@@H]2CN([C@@H]1C(=O)NCc1ncco1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C14H15FN4O6/c1-7-4-8-6-18(14(23)19(8)25-11(15)13(21)22)10(7)12(20)17-5-9-16-2-3-24-9/h2-4,8,10-11H,5-6H2,1H3,(H,17,20)(H,21,22)/t8?,10-,11+/m0/s1 CBBUHGXUJWGHRX-JCBFREDQSA-N 466984 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-2-(oxazol-2-ylmethylcarbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]lacetic acid lithium salt::US10800778, Example 68 Beta-lactamase TEM 310 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466984&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922457 441576677 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965114 CC1=C[C@@H]2CN([C@@H]1C(=O)NCc1cnccn1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C15H16FN5O5/c1-8-4-10-7-20(15(25)21(10)26-12(16)14(23)24)11(8)13(22)19-6-9-5-17-2-3-18-9/h2-5,10-12H,6-7H2,1H3,(H,19,22)(H,23,24)/t10?,11-,12+/m0/s1 SFPTWFMBZJRMKD-GLXQMMQGSA-N 466985 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(pyrazin-2-ylmethyl-carbamoyl)-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 69 Beta-lactamase TEM 180 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466985&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922458 441576678 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965117 CC1=C[C@@H]2CN([C@@H]1C(=O)NOCC1CC1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C14H18FN3O6/c1-7-4-9-5-17(14(22)18(9)24-11(15)13(20)21)10(7)12(19)16-23-6-8-2-3-8/h4,8-11H,2-3,5-6H2,1H3,(H,16,19)(H,20,21)/t9?,10-,11+/m0/s1 OPBQWQXRAFJUEL-QXXIUIOUSA-N 466986 (2S)-2-[[(2S,5R)-2-(cyclopropylmethoxycarbamoyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]-2-fluoro-acetic acid lithium salt::US10800778, Example 70 Beta-lactamase TEM 26.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466986&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922459 441576679 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965120 CC1=C[C@@H]2CN([C@@H]1C(=O)NCCC(N)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C13H17FN4O6/c1-6-4-7-5-17(9(6)11(20)16-3-2-8(15)19)13(23)18(7)24-10(14)12(21)22/h4,7,9-10H,2-3,5H2,1H3,(H2,15,19)(H,16,20)(H,21,22)/t7?,9-,10+/m0/s1 WCRPDOYIEXPPSD-VYDKEIKOSA-N 466987 (2S)-2-[[(2S,5R)-2-[(3-amino-3-oxo-propyl)carbamoyl]-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]-2-fluoro-acetic acid lithium salt::US10800778, Example 71 Beta-lactamase TEM 110 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466987&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922460 441576680 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965123 CC1=C[C@@H]2CN([C@@H]1C(=O)NOC[C@@H]1CCC(=O)N1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C15H19FN4O7/c1-7-4-9-5-19(15(25)20(9)27-12(16)14(23)24)11(7)13(22)18-26-6-8-2-3-10(21)17-8/h4,8-9,11-12H,2-3,5-6H2,1H3,(H,17,21)(H,18,22)(H,23,24)/t8-,9?,11-,12+/m0/s1 FCBPOMQVJRBNEN-WUJXFXLFSA-N 466988 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[(5-oxopyrrolidin-2-yl)methoxycarbamoyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 72 Beta-lactamase TEM 77.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466988&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922461 441576681 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965126 CC1=C[C@@H]2CN([C@@H]1C(=O)NCC[C@@H]1CCC(=O)N1)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C16H21FN4O6/c1-8-6-10-7-20(16(26)21(10)27-13(17)15(24)25)12(8)14(23)18-5-4-9-2-3-11(22)19-9/h6,9-10,12-13H,2-5,7H2,1H3,(H,18,23)(H,19,22)(H,24,25)/t9-,10?,12-,13+/m0/s1 XSJFKEVFSPGNJZ-FZMOHWGLSA-N 466989 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(5-oxopyrrolidin-2-yl)ethylcarbamoyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 73 Beta-lactamase TEM 730 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466989&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922462 441576682 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965129 CC1=C[C@@H]2CN([C@@H]1C(=O)NCCCS(N)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C13H19FN4O7S/c1-7-5-8-6-17(13(22)18(8)25-10(14)12(20)21)9(7)11(19)16-3-2-4-26(15,23)24/h5,8-10H,2-4,6H2,1H3,(H,16,19)(H,20,21)(H2,15,23,24)/t8?,9-,10+/m0/s1 KMIMTPSCZSJCPM-CBMCFHRWSA-N 466990 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(3-sulfamoylpropylcarbamoyl)-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 74 Beta-lactamase TEM 280 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466990&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922463 441576683 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965132 CC1=C[C@@H]2CN([C@@H]1C(=O)NCCNS(N)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C12H18FN5O7S/c1-6-4-7-5-17(12(22)18(7)25-9(13)11(20)21)8(6)10(19)15-2-3-16-26(14,23)24/h4,7-9,16H,2-3,5H2,1H3,(H,15,19)(H,20,21)(H2,14,23,24)/t7?,8-,9+/m0/s1 ABPLMHATNQPHNC-SXNZSPLWSA-N 466991 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(sulfamoylamino)ethyl-carbamoyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 75 Beta-lactamase TEM 83.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466991&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922464 441576684 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965135 CC1=C[C@@H]2CN([C@@H]1CNC(=O)OC(C)(C)C)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C15H22FN3O6/c1-8-5-9-7-18(14(23)19(9)25-11(16)12(20)21)10(8)6-17-13(22)24-15(2,3)4/h5,9-11H,6-7H2,1-4H3,(H,17,22)(H,20,21)/t9?,10-,11-/m1/s1 NHCGBXGSGNHZFN-FHZGLPGMSA-N 466992 (2S)-2-[[(2S,5R)-2-[tert-butoxycarbonylamino)methyl]-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]-2-fluoro-acetic acid lithium salt::US10800778, Example 76 Beta-lactamase TEM 940 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466992&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922465 441576685 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965138 CC1=C[C@@H]2CN([C@@H]1CN)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C10H14FN3O4/c1-5-2-6-4-13(7(5)3-12)10(17)14(6)18-8(11)9(15)16/h2,6-8H,3-4,12H2,1H3,(H,15,16)/t6?,7-,8-/m1/s1 VNFWGXIYPXWXBS-SPDVFEMOSA-N 466993 (2S)-2-[[(2S,5R)-2-(aminomethyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]-2-fluoro-acetic acid::US10800778, Example 77 Beta-lactamase TEM >100000 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466993&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922466 441576686 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965141 CC(=O)NC[C@H]1N2C[C@@H](C=C1C)N(O[C@@H](F)C(O)=O)C2=O InChI=1S/C12H16FN3O5/c1-6-3-8-5-15(9(6)4-14-7(2)17)12(20)16(8)21-10(13)11(18)19/h3,8-10H,4-5H2,1-2H3,(H,14,17)(H,18,19)/t8?,9-,10-/m1/s1 SURSZFGYJRFQEX-VXRWAFEHSA-N 466994 (2S)-2-[[(2S,5R)-2- (acetamidomethyl)-3-methyl-7- oxo-1,6-diazabicyclo[3.2.1]oct-3- en-6-yl]oxy]-2-fluoro-acetic acid lithium salt::US10800778, Example 78 Beta-lactamase TEM 3600 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466994&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922467 441576687 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965144 CC1=C[C@@H]2CN([C@@H]1CNC(=O)C(F)(F)F)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C12H13F4N3O5/c1-5-2-6-4-18(7(5)3-17-10(22)12(14,15)16)11(23)19(6)24-8(13)9(20)21/h2,6-8H,3-4H2,1H3,(H,17,22)(H,20,21)/t6?,7-,8-/m1/s1 WKUUKIISZDMTQV-SPDVFEMOSA-N 466995 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[[(2,2,2-trifluoroacetyl)-aminolmethyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 79 Beta-lactamase TEM 4200 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466995&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922468 441576688 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965147 CC1=C[C@@H]2CN([C@@H]1C(=O)NCC#N)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C12H13FN4O5/c1-6-4-7-5-16(8(6)10(18)15-3-2-14)12(21)17(7)22-9(13)11(19)20/h4,7-9H,3,5H2,1H3,(H,15,18)(H,19,20)/t7?,8-,9+/m0/s1 OOBLDYJFUBJOPF-SXNZSPLWSA-N 466996 (2S)-2-fluoro-2-[[(2S,5R)-2-(cyanomethylcarbamoyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 82 Beta-lactamase TEM 85.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466996&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922469 441576689 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965150 CC1=C[C@@H]2CN([C@@H]1C(=O)NCO)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C11H14FN3O6/c1-5-2-6-3-14(7(5)9(17)13-4-16)11(20)15(6)21-8(12)10(18)19/h2,6-8,16H,3-4H2,1H3,(H,13,17)(H,18,19)/t6?,7-,8+/m0/s1 DIRLPWJRIWGPCS-ZHFSPANRSA-N 466997 (2S)-2-fluoro-2-[[(2S,5R)-2-(hydroxymethylcarbamoyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 87 Beta-lactamase TEM 150 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466997&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922470 441576690 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965153 CC(=O)NCNC(=O)[C@H]1N2C[C@@H](C=C1C)N(O[C@@H](F)C(O)=O)C2=O InChI=1S/C13H17FN4O6/c1-6-3-8-4-17(9(6)11(20)16-5-15-7(2)19)13(23)18(8)24-10(14)12(21)22/h3,8-10H,4-5H2,1-2H3,(H,15,19)(H,16,20)(H,21,22)/t8?,9-,10+/m0/s1 FXRXKUVQNAIPQC-CBMCFHRWSA-N 466998 (2S)-2-fluoro-2-[[(2S,5R)-2-(acetamidomethylcarbamoyl)-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 88 Beta-lactamase TEM 54.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466998&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922471 441576691 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965156 CC1=C[C@@H]2CN([C@@H]1C(=O)NCNS(N)(=O)=O)C(=O)N2O[C@@H](F)C(O)=O InChI=1S/C11H16FN5O7S/c1-5-2-6-3-16(11(21)17(6)24-8(12)10(19)20)7(5)9(18)14-4-15-25(13,22)23/h2,6-8,15H,3-4H2,1H3,(H,14,18)(H,19,20)(H2,13,22,23)/t6?,7-,8+/m0/s1 FCBUHCWXTMAQGJ-ZHFSPANRSA-N 466999 (2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[(sulfamoylamino)-methylcarbamoyl]-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxy]acetic acid lithium salt::US10800778, Example 89 Beta-lactamase TEM 33.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=466999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=466999&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922472 441576692 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965159 CC1=C[C@H](N2C[C@@H]1N(OC(F)(F)C(O)=O)C2=O)C(N)=O InChI=1S/C10H11F2N3O5/c1-4-2-5(7(13)16)14-3-6(4)15(9(14)19)20-10(11,12)8(17)18/h2,5-6H,3H2,1H3,(H2,13,16)(H,17,18)/t5-,6?/m0/s1 KHQWVYGFKAJISE-ZBHICJROSA-N 467000 2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2,2-difluoroacetic acid lithium salt::US10800778, Example 91 Beta-lactamase TEM 0.470 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=467000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=467000&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922473 441576693 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965162 CC1=C[C@H](N2C[C@@H]1N(OCC(O)=O)C2=O)C(N)=O InChI=1S/C10H13N3O5/c1-5-2-6(9(11)16)12-3-7(5)13(10(12)17)18-4-8(14)15/h2,6-7H,3-4H2,1H3,(H2,11,16)(H,14,15)/t6-,7?/m0/s1 TYGMQYXAGAWAHU-PKPIPKONSA-N 467001 2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)acetic acid lithium salt::US10800778, Example 93 Beta-lactamase TEM 150 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=467001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=467001&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922474 441576694 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965165 CC1=C[C@@H](C#N)N2C[C@@H]1N(O[C@H](F)C(O)=O)C2=O InChI=1S/C10H10FN3O4/c1-5-2-6(3-12)13-4-7(5)14(10(13)17)18-8(11)9(15)16/h2,6-8H,4H2,1H3,(H,15,16)/t6-,7?,8-/m0/s1 BVKNUAKQEQUMSY-PPSBICQBSA-N 467002 (2R)-2-(((2S,5R)-2-cyano-4-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl)oxy)-2-fluoroacetic acid lithium salt::US10800778, Example 95 Beta-lactamase TEM 35.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=467002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=467002&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922475 441576695 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965168 NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2O[C@H](F)C(O)=O InChI=1S/C9H12FN3O5/c10-6(8(15)16)18-13-4-1-2-5(7(11)14)12(3-4)9(13)17/h4-6H,1-3H2,(H2,11,14)(H,15,16)/t4?,5-,6-/m0/s1 XMFJVBXAWNAOLU-VZLNHYCJSA-N 467003 US10800778, Comparator 98 Beta-lactamase TEM 1.30 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=467003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=467003&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922476 441576696 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 965171 OC(=O)C(F)ON1[C@H]2CN([C@@H](CC2)C(=O)NC2CCNCC2)C1=O InChI=1S/C14H21FN4O5/c15-11(13(21)22)24-19-9-1-2-10(18(7-9)14(19)23)12(20)17-8-3-5-16-6-4-8/h8-11,16H,1-7H2,(H,17,20)(H,21,22)/t9?,10-,11?/m0/s1 RMNUWMLNSDZJHP-YVNMAJEFSA-N 467004 US10800778, Comparator 99 Beta-lactamase TEM 30.0 US Patent 10.7270/Q2DF6V9G aid1804902 US10800778 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Entasis Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=467004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=467004&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 155922477 441576697 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409322 OB1OC(c2ccccc12)c1ccccc1 InChI=1S/C13H11BO2/c15-14-12-9-5-4-8-11(12)13(16-14)10-6-2-1-3-7-10/h1-9,13,15H UJEQOMQHKUCKBE-UHFFFAOYSA-N 50569204 CHEMBL4864824 Beta-lactamase TEM 4460 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569204&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 23642211 471059349 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409323 OB1OC(c2cccs2)c2ccccc12 InChI=1S/C11H9BO2S/c13-12-9-5-2-1-4-8(9)11(14-12)10-6-3-7-15-10/h1-7,11,13H GCXLARMWTQLWFL-UHFFFAOYSA-N 50569205 CHEMBL4878895 Beta-lactamase TEM 6970 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569205&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164627328 471059350 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409324 OB1OC(c2c[nH]c3ccccc23)c2ccccc12 50569206 CHEMBL4875860 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569206&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164627677 471059351 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409325 OB1OC(c2ccccc12)c1c[nH]c2ccc(F)cc12 50569207 CHEMBL4861951 Beta-lactamase TEM 88830 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569207&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164620790 471059352 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409326 OB1OC(c2ccccc12)c1c[nH]c2ccc(Cl)cc12 50569208 CHEMBL4861004 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569208&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164614790 471059353 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409327 OB1OC(c2ccccc12)c1c[nH]c2ccc(Br)cc12 50569209 CHEMBL4864629 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569209&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164619598 471059354 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409328 Cc1ccc2[nH]cc(C3OB(O)c4ccccc34)c2c1 50569210 CHEMBL4871947 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569210&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164622985 471059355 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409329 OB1OC(c2ccccc12)c1c[nH]c2ccc(OCc3ccccc3)cc12 50569211 CHEMBL4864134 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569211&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164623688 471059356 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409330 OB1OC(c2ccccc12)c1cn(Cc2ccccc2)c2ccccc12 InChI=1S/C22H18BNO2/c25-23-20-12-6-4-11-18(20)22(26-23)19-15-24(14-16-8-2-1-3-9-16)21-13-7-5-10-17(19)21/h1-13,15,22,25H,14H2 BRTRRULEKXKADL-UHFFFAOYSA-N 50569212 CHEMBL4872823 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569212&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164619470 471059357 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409331 OB1OC(c2c[nH]c3ccccc23)c2c1cccc2F 50569213 CHEMBL4878058 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569213&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164626229 471059358 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409332 OB1OC(c2ccc(F)cc12)c1c[nH]c2ccc(Br)cc12 50569214 CHEMBL4851510 Beta-lactamase TEM >100000 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569214&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164610631 471059359 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409333 CN(C)c1ccc(cc1)C1OB(O)c2ccccc12 InChI=1S/C15H16BNO2/c1-17(2)12-9-7-11(8-10-12)15-13-5-3-4-6-14(13)16(18)19-15/h3-10,15,18H,1-2H3 FGWIPVZZFGHNIN-UHFFFAOYSA-N 50569215 CHEMBL4875926 Beta-lactamase TEM 730 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569215&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164629098 471059360 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409334 CNc1ccc(cc1)C1OB(O)c2ccccc12 InChI=1S/C14H14BNO2/c1-16-11-8-6-10(7-9-11)14-12-4-2-3-5-13(12)15(17)18-14/h2-9,14,16-17H,1H3 HDZYUBJLIWKDBR-UHFFFAOYSA-N 50569216 CHEMBL4875825 Beta-lactamase TEM 3200 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569216&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164626810 471059361 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409335 OB1OC(c2ccccc12)c1ccc(cc1)N1CCCCC1 InChI=1S/C18H20BNO2/c21-19-17-7-3-2-6-16(17)18(22-19)14-8-10-15(11-9-14)20-12-4-1-5-13-20/h2-3,6-11,18,21H,1,4-5,12-13H2 JAUYRIGRSLGYJB-UHFFFAOYSA-N 50569217 CHEMBL4861373 Beta-lactamase TEM 32960 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569217&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164613159 471059362 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409336 CN(C)c1ccc(cc1)C1OB(O)c2cccc(F)c12 InChI=1S/C15H15BFNO2/c1-18(2)11-8-6-10(7-9-11)15-14-12(16(19)20-15)4-3-5-13(14)17/h3-9,15,19H,1-2H3 XBNZCPAWEBAFJL-UHFFFAOYSA-N 50569218 CHEMBL4856812 Beta-lactamase TEM 20730 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569218&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164613566 471059363 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409337 CNc1ccc(cc1)C1OB(O)c2cccc(F)c12 InChI=1S/C14H13BFNO2/c1-17-10-7-5-9(6-8-10)14-13-11(15(18)19-14)3-2-4-12(13)16/h2-8,14,17-18H,1H3 WZKAIFIGYGULOA-UHFFFAOYSA-N 50569219 CHEMBL4849046 Beta-lactamase TEM 37870 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569219&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164616111 471059364 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409338 CN(C)c1ccc(cc1)C1OB(O)c2ccc(Cl)cc12 InChI=1S/C15H15BClNO2/c1-18(2)12-6-3-10(4-7-12)15-13-9-11(17)5-8-14(13)16(19)20-15/h3-9,15,19H,1-2H3 BBNXKBWPPCQJID-UHFFFAOYSA-N 50569220 CHEMBL4855048 Beta-lactamase TEM 1540 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569220&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164617486 471059365 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409339 CN(C)c1ccc(cc1)C1OB(O)c2ccc(F)cc12 InChI=1S/C15H15BFNO2/c1-18(2)12-6-3-10(4-7-12)15-13-9-11(17)5-8-14(13)16(19)20-15/h3-9,15,19H,1-2H3 VQFQQGRNDCWXHH-UHFFFAOYSA-N 50569221 CHEMBL4875141 Beta-lactamase TEM 5680 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569221&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164629053 471059366 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409340 COc1ccc2B(O)OC(c2c1)c1ccc(cc1)N(C)C InChI=1S/C16H18BNO3/c1-18(2)12-6-4-11(5-7-12)16-14-10-13(20-3)8-9-15(14)17(19)21-16/h4-10,16,19H,1-3H3 ISUNOYZLVNVLGY-UHFFFAOYSA-N 50569222 CHEMBL4866950 Beta-lactamase TEM 1540 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569222&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164618842 471059367 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409341 CN(C)c1ccc(cc1)C1OB(O)c2cc(Cl)ccc12 InChI=1S/C15H15BClNO2/c1-18(2)12-6-3-10(4-7-12)15-13-8-5-11(17)9-14(13)16(19)20-15/h3-9,15,19H,1-2H3 YMZHMVXNMWFADQ-UHFFFAOYSA-N 50569223 CHEMBL4858119 Beta-lactamase TEM 4340 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569223&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164612469 471059368 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409342 CN(C)c1ccc(cc1)C1OB(O)c2cc3OCOc3cc12 InChI=1S/C16H16BNO4/c1-18(2)11-5-3-10(4-6-11)16-12-7-14-15(21-9-20-14)8-13(12)17(19)22-16/h3-8,16,19H,9H2,1-2H3 ILPWDRPGOMZETE-UHFFFAOYSA-N 50569224 CHEMBL4879305 Beta-lactamase TEM 1150 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50569224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50569224&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search 164627341 471059369 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313 51409343 NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1 NDCUAPJVLWFHHB-UHNVWZDZSA-N 50339145 CHEMBL1689063::trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide Beta-lactamase TEM 1.9 ChEMBL 10.1016/j.bmcl.2021.127956 10.7270/Q2B85CX1 33744439 Yan, YH; Li, ZF; Ning, XL; Deng, J; Yu, JL; Luo, Y; Wang, Z; Li, G; Li, GB; Xiao, YC Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7704&target=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339145&enzyme=Beta-lactamase+TEM&column=ki&startPg=0&Increment=50&submit=Search FYG 7KEQ,7KEP,7KER 9835049 125089247 CHEMBL1689063 C02000 ZINC09302239 1 MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW 1ERM,1ERO,1ERQ,1ESU,1FQG,1JTD,1JVJ,1JWP,1JWV,1LHY,1LI9,1M40,1NXY,1NY0,1NYM,1NYY,1PZO,1PZP,1S0W,1XPB,1YT4,2V1Z,2V20,3CMZ,3DTM,3JYI,3P98,4DXB,4DXC,4GKU,4ZJ2,5AQ8,5HVI,5HW1,5HW5,5NPO,6B2N,7QLP,7QNK,7U6Q,8DE0 Beta-lactamase TEM BLAT_ECOLX P62593 P00810 Q47313