BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 843877 Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 387815 US10294226, Compound A::US10487083, Example A::US11059823, Example A Tyrosine-protein kinase JAK3 [512-1124] 12.4 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387815&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 71212257 404856920 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843881 OCCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 420028 US10487083, Example B Tyrosine-protein kinase JAK3 [512-1124] 13.4 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420028&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843885 C[C@@H](O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C18H21N5O/c1-11(24)18-22-15-10-21-17-14(7-9-20-17)16(15)23(18)13-4-2-12(3-5-13)6-8-19/h7,9-13,24H,2-6H2,1H3,(H,20,21)/t11-,12-,13-/m1/s1 IKSRDHMMQOCRHN-JHJVBQTASA-N 50434787 CHEMBL2386635::US10487083, Example C::US10703751, Example 644 of WO2011086053::US11059823, Example C Tyrosine-protein kinase JAK3 [512-1124] 49.7 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434787&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 1J6 4IVC 58395078 175447104 CHEMBL2386635 ZINC72315832 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843889 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 387818 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10294226, Compound Ex. 1::US10487083, Example 1::US10981911, Example 1::US11059823, Example 1 Tyrosine-protein kinase JAK3 [512-1124] 92.2 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387818&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611548 404856923 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843893 N#CC[C@H]1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1 InChI=1S/C19H17N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2/b19-16-/t12-,13? TWQNOXWGOZAOAH-IBTUIJKBSA-N 387819 2-((1r,4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10294226, Compound Ex. 2::US10487083, Example 2::US10981911, Example 2 Tyrosine-protein kinase JAK3 [512-1124] 33.9 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387819&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137279255 404856924 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843897 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC1CC1 387820 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(cyclopropylmethyl)acetamide::US10294226, Compound Ex. 3::US10487083, Example 3::US10981911, Example 3::US11059823, Example 3 Tyrosine-protein kinase JAK3 [512-1124] 82.8 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387820&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611606 404856925 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843901 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCCC#N 387821 N-(2-Cyanoethyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 4::US10487083, Example 4::US10981911, Example 4::US11059823, Example 4 Tyrosine-protein kinase JAK3 [512-1124] 96.2 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387821&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611545 404856926 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843905 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CCOCC1 387822 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)acetamide::US10294226, Compound Ex. 5::US10487083, Example 5::US10981911, Example 5::US11059823, Example 5 Tyrosine-protein kinase JAK3 [512-1124] 23.1 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387822&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611547 404856927 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843909 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC1CCOCC1 387823 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide::US10294226, Compound Ex. 6::US10487083, Example 6::US10981911, Example 10::US11059823, Example 6 Tyrosine-protein kinase JAK3 [512-1124] 28.2 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387823&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611561 404856928 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843913 CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C#N 387824 N-(2-Cyano-2-methylpropyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 7::US10487083, Example 7::US10981911, Example 22::US11059823, Example 7 Tyrosine-protein kinase JAK3 [512-1124] 98.4 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387824&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611580 404856929 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843917 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CCC1 387825 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclobutyl)methyl)acetamide::US10294226, Compound Ex. 8::US10487083, Example 8::US10981911, Example 34::US11059823, Example 8 Tyrosine-protein kinase JAK3 [512-1124] 75.6 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387825&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611549 404856930 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843921 Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cn1 387826 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1-methyl-1H-pyrazol-4-yl)acetamide::US10294226, Compound Ex. 9::US10487083, Example 9::US10981911, Example 38::US11059823, Example 9 Tyrosine-protein kinase JAK3 [512-1124] 79.9 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387826&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611573 404856931 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843925 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC12CCC(CC#N)(CC1)C2 387827 N-(4-(Cyanomethyl)bicyclo[2.2.1]heptan-1-yl)-2-(1-((1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 10::US10487083, Example 10::US10981911, Example 55::US11059823, Example 10 Tyrosine-protein kinase JAK3 [512-1124] 87.5 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387827&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611542 404856932 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843929 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1cc[nH]n1 387828 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1H-pyrazol-3-yl)acetamide::US10294226, Compound Ex. 11::US10487083, Example 11::US10981911, Example 74::US11059823, Example 11 Tyrosine-protein kinase JAK3 [512-1124] 30.3 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387828&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611570 404856933 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 843933 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CC1 387829 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclopropyl)methyl)acetamide::US10294226, Compound Ex. 12::US10487083, Example 12::US10981911, Example 85::US11059823, Example 12 Tyrosine-protein kinase JAK3 [512-1124] 101 US Patent 10.7270/Q2SX6GM6 aid1803967 US10487083 Kreutter, KD; Leonard, K; Rizzolio, MC; Smith, RC; Tichenor, MS; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387829&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611598 404856934 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026045 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 387818 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10294226, Compound Ex. 1::US10487083, Example 1::US10981911, Example 1::US11059823, Example 1 Tyrosine-protein kinase JAK3 [512-1124] 87.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387818&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611548 404856923 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026049 N#CC[C@H]1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1 InChI=1S/C19H17N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2/b19-16-/t12-,13? TWQNOXWGOZAOAH-IBTUIJKBSA-N 387819 2-((1r,4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10294226, Compound Ex. 2::US10487083, Example 2::US10981911, Example 2 Tyrosine-protein kinase JAK3 [512-1124] 33.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387819&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137279255 404856924 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026053 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC1CC1 387820 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(cyclopropylmethyl)acetamide::US10294226, Compound Ex. 3::US10487083, Example 3::US10981911, Example 3::US11059823, Example 3 Tyrosine-protein kinase JAK3 [512-1124] 82.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387820&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611606 404856925 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026057 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCCC#N 387821 N-(2-Cyanoethyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 4::US10487083, Example 4::US10981911, Example 4::US11059823, Example 4 Tyrosine-protein kinase JAK3 [512-1124] 96.2 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387821&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611545 404856926 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026061 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CCOCC1 387822 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)acetamide::US10294226, Compound Ex. 5::US10487083, Example 5::US10981911, Example 5::US11059823, Example 5 Tyrosine-protein kinase JAK3 [512-1124] 23.1 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387822&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611547 404856927 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026065 FC(F)(F)C1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493065 2-((1r,4r)-4-(2-(2-Oxo-2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 6 Tyrosine-protein kinase JAK3 [512-1124] 49.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493065&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142713 447119750 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026069 OCc1ccc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1 493066 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(hydroxymethyl)phenyl)acetamide::US10981911, Example 7 Tyrosine-protein kinase JAK3 [512-1124] 13.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493066&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142619 447119751 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026073 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccc(CC#N)cc1 493067 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(cyanomethyl)phenyl)acetamide::US10981911, Example 8 Tyrosine-protein kinase JAK3 [512-1124] 12.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493067&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143096 447119752 C04116 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026077 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1nc[nH]n1 InChI=1S/C18H16N8/c19-7-5-11-1-3-12(4-2-11)26-15-13-6-8-20-16(13)21-9-14(15)24-18(26)17-22-10-23-25-17/h6,8-12H,1-5H2/b18-17+/t11-,12- UPKCTJYCVZLTGW-WFMRDXOLSA-N 493068 2-((1r,4r)-4-(2-(1H-1,2,4-Triazol-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 9 Tyrosine-protein kinase JAK3 [512-1124] 48.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493068&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297635 447119753 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026081 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC1CCOCC1 387823 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide::US10294226, Compound Ex. 6::US10487083, Example 6::US10981911, Example 10::US11059823, Example 6 Tyrosine-protein kinase JAK3 [512-1124] 28.2 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387823&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611561 404856928 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026085 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cocn1 493070 2-((1r,4r)-4-(2-(Oxazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 11 Tyrosine-protein kinase JAK3 [512-1124] 33.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493070&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142890 447119755 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026089 OC1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493071 2-((1r,4r)-4-(2-(2-(4-Hydroxypiperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 12 Tyrosine-protein kinase JAK3 [512-1124] 99.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493071&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142705 447119756 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026093 O=S(=O)(CCC#N)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493072 2-Cyano-N-((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)ethanesulfonamide::US10981911, Example 13 Tyrosine-protein kinase JAK3 [512-1124] 651 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493072&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142918 447119757 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026097 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccncn1 493073 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(pyrimidin-4-ylmethyl)acetamide::US10981911, Example 14 Tyrosine-protein kinase JAK3 [512-1124] 43.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493073&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142637 447119758 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026101 CC(C)(CO)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493074 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(3-hydroxy-2,2-dimethylpropyl)acetamide::US10981911, Example 15 Tyrosine-protein kinase JAK3 [512-1124] 54.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493074&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142427 447119759 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026517 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccncc1 493179 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(pyridin-4-yl)acetamide::US10981911, Example 118 Tyrosine-protein kinase JAK3 [512-1124] 50.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493179&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142730 447119864 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026521 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cncs1 493180 2-((1r,4r)-4-(2-(Thiazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 119 Tyrosine-protein kinase JAK3 [512-1124] 117 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493180&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143138 447119865 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026525 COCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493181 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-methoxyethyl)acetamide::US10981911, Example 120 Tyrosine-protein kinase JAK3 [512-1124] 228 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493181&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193308 447119866 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026529 OCc1ccc(cc1)C(=O)c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493182 2-((1r,4r)-4-(2-(4-(4-(Hydroxymethyl)benzoyl)phenyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 121 Tyrosine-protein kinase JAK3 [512-1124] 431 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493182&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142725 447119867 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026533 O=C(NC1COC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493183 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(oxetan-3-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 122 Tyrosine-protein kinase JAK3 [512-1124] 437 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493183&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142925 447119868 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026537 O=C(Nc1cn[nH]c1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493184 2-((1r,4r)-4-(2-(1H-pyrazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 123 Tyrosine-protein kinase JAK3 [512-1124] 146 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493184&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 156280095 447119869 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026105 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cn[nH]n1 InChI=1S/C18H16N8/c19-7-5-11-1-3-12(4-2-11)26-16-13-6-8-20-17(13)21-9-14(16)23-18(26)15-10-22-25-24-15/h6,8-12H,1-5H2/b18-15-/t11-,12- RGWMWRKGEBUXAW-QQMGJYJCSA-N 493075 2-((1r,4r)-4-(2-(2H-1,2,3-Triazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 16 Tyrosine-protein kinase JAK3 [512-1124] 37.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493075&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297632 447119760 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026109 O\N=C(\NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493076 (E)-N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-hydroxybenzimidamide::US10981911, Example 17A Tyrosine-protein kinase JAK3 [512-1124] 65.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493076&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142606 447119761 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026113 O\N=C(/NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493077 (Z)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[23-b]pyridin-2-yl)methyl)-N-hydroxybenzimidamide::US10981911, Example 17B Tyrosine-protein kinase JAK3 [512-1124] 102 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493077&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142606 447119762 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026117 OC1CN(C1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493078 2-((1r,4r)-4-(2-(2-(3-Hydroxyazetidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 18 Tyrosine-protein kinase JAK3 [512-1124] 540 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493078&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142863 447119763 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026121 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N[C@H]1CC[C@H](CC#N)CC1 493079 N-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 19 Tyrosine-protein kinase JAK3 [512-1124] 31.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493079&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142440 447119764 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026125 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccccc1 493080 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-phenylacetamide::US10981911, Example 20 Tyrosine-protein kinase JAK3 [512-1124] 20.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493080&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142436 447119765 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026129 OC12CC3CC(C1)CC(CNC(=O)Cc1nc4cnc5[nH]ccc5c4n1[C@H]1CC[C@H](CC#N)CC1)(C3)C2 493081 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(((1S,3R,5R,7S)-3-hydroxyadamantan-1-yl)methyl)acetamide::US10981911, Example 21 Tyrosine-protein kinase JAK3 [512-1124] 55.1 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493081&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146213263 447119766 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026133 CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C#N 387824 N-(2-Cyano-2-methylpropyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 7::US10487083, Example 7::US10981911, Example 22::US11059823, Example 7 Tyrosine-protein kinase JAK3 [512-1124] 93.6 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387824&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611580 404856929 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026137 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC12CCC(CC1)(C2)C#N 493083 N-(4-Cyanobicyclo[2.2.1]heptan-1-yl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 23 Tyrosine-protein kinase JAK3 [512-1124] 38.1 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493083&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142689 447119768 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026141 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)COC1 493084 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((3-hydroxyoxetan-3-yl)methyl)acetamide::US10981911, Example 24 Tyrosine-protein kinase JAK3 [512-1124] 57.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493084&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193305 447119769 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026145 N#CC[C@H]1CC[C@@H](CC1)n1c(Cc2ccn[nH]2)nc2cnc3[nH]ccc3c12 493085 2-((1r,4r)-4-(2-((1H-Pyrazol-5-yl)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 25 Tyrosine-protein kinase JAK3 [512-1124] 77.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493085&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142438 447119770 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026149 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCC(CC1)N1CCOCC1 InChI=1S/C27H35N7O2/c28-9-5-19-1-3-21(4-2-19)34-24(31-23-18-30-27-22(26(23)34)6-10-29-27)17-25(35)33-11-7-20(8-12-33)32-13-15-36-16-14-32/h6,10,18-21H,1-5,7-8,11-17H2,(H,29,30)/t19-,21- JDRBWHJXQOIQSD-XUTJKUGGSA-N 50527405 CHEMBL4456630::US10981911, Example 26 Tyrosine-protein kinase JAK3 [512-1124] 106 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527405&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379949 440735987 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026153 OC[C@H]1CC[C@@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493087 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)acetamide::US10981911, Example 27 Tyrosine-protein kinase JAK3 [512-1124] 36.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493087&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143099 447119772 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026157 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CCCCC1 493088 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-cyclohexylacetamide::US10981911, Example 28 Tyrosine-protein kinase JAK3 [512-1124] 32.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493088&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143100 447119773 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026161 OCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493089 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxyethyl)acetamide::US10981911, Example 29 Tyrosine-protein kinase JAK3 [512-1124] 67.2 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493089&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142933 447119774 C04080 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026541 N\C(=N/OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493185 (Z*)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)benzimidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 124 Tyrosine-protein kinase JAK3 [512-1124] 141 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493185&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142947 447119870 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026545 COCC\C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)=N\O 493186 (EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-hydroxy-3-methoxypropanimidamide::US10981911, Example 125 Tyrosine-protein kinase JAK3 [512-1124] 622 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493186&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142922 447119871 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026549 O=C(c1ccc(COCc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)c1ccc(cc1)C#C 493187 2-((1r,4r)-4-(2-(((4-(4-Ethynylbenzoyl)benzyl)oxy)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 126 Tyrosine-protein kinase JAK3 [512-1124] 317 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493187&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142969 447119872 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026553 O[C@@H]1CCN(C1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493188 2-((1r,4r)-4-(2-(2-((R)-3-Hydroxypyrrolidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 127 Tyrosine-protein kinase JAK3 [512-1124] 788 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493188&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142938 447119873 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026557 CCOC(=O)N1CC(C1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493189 Ethyl 3-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)azetidine-1-carboxylate::US10981911, Example 128 Tyrosine-protein kinase JAK3 [512-1124] 1088 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493189&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142961 447119874 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026561 CC(C)c1noc(=O)n1Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493190 2-((1r,4r)-4-(2-((3-Isopropyl-5-oxo-1,2,4-oxadiazol-4(5H)-yl)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 129 Tyrosine-protein kinase JAK3 [512-1124] 2695 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493190&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142929 447119875 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026565 O=C(c1ccc(OCc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)c1ccc(cc1)C#C 493191 2-((1r,4r)-4-(2-((4-(4-Ethynylbenzoyl)phenoxy)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 130 Tyrosine-protein kinase JAK3 [512-1124] 130 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493191&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142939 447119876 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026569 OCC12CCC(CC1)(C2)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493192 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(hydroxymethyl)bicyclo[2.2.1]heptan-1-yl)acetamide::US10981911, Example 131 Tyrosine-protein kinase JAK3 [512-1124] 100 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493192&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379918 447119877 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026573 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]cc(F)c3c2n1[C@H]1CC[C@H](CC#N)CC1 493193 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-8-fluoro-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10981911, Example 132 Tyrosine-protein kinase JAK3 [512-1124] 61.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493193&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193369 447119878 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026577 CNC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493194 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 133 Tyrosine-protein kinase JAK3 [512-1124] 154 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493194&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142972 447119879 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026581 CS(=O)(=O)N1CC(C1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493195 2-((1r,4r)-4-(2-(1-(Methylsulfonyl)azetidin-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 134 Tyrosine-protein kinase JAK3 [512-1124] 1290 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493195&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142926 447119880 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026585 C[Si](C)(C)[C@@H]1CC[C@@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493198 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1S,4S)-4-(trimethylsilyl)cyclohexyl)acetamide::US10981911, Example 135 Tyrosine-protein kinase JAK3 [512-1124] 54.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493198&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 153445216 447119883 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026589 OC1(CNC(=O)c2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CCCCCC1 493200 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-((1-hydroxycycloheptyl)methyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 136 Tyrosine-protein kinase JAK3 [512-1124] 65.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493200&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142439 447119885 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026593 CC(C)COC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493201 Isobutyl ((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)carbamate::US10981911, Example 137 Tyrosine-protein kinase JAK3 [512-1124] 280 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493201&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379872 447119886 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026597 O=C(NCCC#N)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493202 N-(2-Cyanoethyl)-1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 138 Tyrosine-protein kinase JAK3 [512-1124] 195 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493202&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142888 447119887 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026165 N=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493090 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzimidamide::US10981911, Example 30 Tyrosine-protein kinase JAK3 [512-1124] 996 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493090&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142649 447119775 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026169 Clc1c[nH]nc1-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C19H16ClN7/c20-14-9-24-26-16(14)19-25-15-10-23-18-13(6-8-22-18)17(15)27(19)12-3-1-11(2-4-12)5-7-21/h6,8-12H,1-5H2/b19-16+/t11-,12- WGLPNYUMXGBKKM-PIFXALSSSA-N 493091 2-((1r,4r)-4-(2-(4-Chloro-1H-pyrazol-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 31 Tyrosine-protein kinase JAK3 [512-1124] 121 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493091&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193379 447119776 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026173 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC12CC3CC(CC(C3)C1)C2 493092 N-((3R,5R)-Adamantan-1-yl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 32 Tyrosine-protein kinase JAK3 [512-1124] 59.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493092&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142859 447119777 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026177 O[C@H]1CC[C@@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C24H30N6O2/c25-11-9-15-1-5-17(6-2-15)30-21(13-22(32)28-16-3-7-18(31)8-4-16)29-20-14-27-24-19(23(20)30)10-12-26-24/h10,12,14-18,31H,1-9,13H2,(H,26,27)(H,28,32)/t15-,16-,17-,18- JFEOTMHLMSEPBP-OPMHRUBESA-N 50527407 CHEMBL4582390::US10981911, Example 33 Tyrosine-protein kinase JAK3 [512-1124] 38.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527407&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142625 440735989 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026181 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CCC1 387825 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclobutyl)methyl)acetamide::US10294226, Compound Ex. 8::US10487083, Example 8::US10981911, Example 34::US11059823, Example 8 Tyrosine-protein kinase JAK3 [512-1124] 42.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387825&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611549 404856930 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026185 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1cnccn1 493095 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(pyrazin-2-ylmethyl)acetamide::US10981911, Example 35 Tyrosine-protein kinase JAK3 [512-1124] 107 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493095&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142851 447119780 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026189 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ncc[nH]1 493096 N-((1H-imidazol-2-yl)methyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 36 Tyrosine-protein kinase JAK3 [512-1124] 12.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493096&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126075 447119781 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026193 O[C@H]1C[C@@H](C1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493097 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1R,3R)-3-hydroxycyclobutyl)acetamide::US10981911, Example 37 Tyrosine-protein kinase JAK3 [512-1124] 38.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493097&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193309 447119782 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026197 Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cn1 387826 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1-methyl-1H-pyrazol-4-yl)acetamide::US10294226, Compound Ex. 9::US10487083, Example 9::US10981911, Example 38::US11059823, Example 9 Tyrosine-protein kinase JAK3 [512-1124] 79.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387826&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611573 404856931 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026201 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccc(cc1)C#N 493099 N-(4-Cyanobenzyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 39 Tyrosine-protein kinase JAK3 [512-1124] 142 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493099&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142842 447119784 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026205 NC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493100 1-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)urea::US10981911, Example 40 Tyrosine-protein kinase JAK3 [512-1124] 47.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493100&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142856 447119785 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026209 N#CC[C@H]1CC[C@@H](CC1)n1c(Cc2cscn2)nc2cnc3[nH]ccc3c12 493101 2-((1r,4r)-4-(2-(Thiazol-4-ylmethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 41 Tyrosine-protein kinase JAK3 [512-1124] 19.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493101&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142433 447119786 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026213 O[C@H]1CCN(C1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493102 2-((1S,4r)-4-(2-(2-((S)-3-Hydroxypyrrolidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 42 Tyrosine-protein kinase JAK3 [512-1124] 439 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493102&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126497 447119787 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026217 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCCOc1ccncc1 493103 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-(pyridin-4-yloxy)ethyl)acetamide::US10981911, Example 43 Tyrosine-protein kinase JAK3 [512-1124] 87.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493103&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193310 447119788 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026601 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C1CCCCC1 493204 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)cyclohexanecarboxamide::US10981911, Example 139 Tyrosine-protein kinase JAK3 [512-1124] 746 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493204&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143000 447119889 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026605 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)C1NC(=NO1)C1CC1 493205 2-((1r,4r)-4-(2-(3-Cyclopropyl-4,5-dihydro-1,2,4-oxadiazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 140 Tyrosine-protein kinase JAK3 [512-1124] 56.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493205&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142464 447119890 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026609 O=S(=O)(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C1CCCCC1 493206 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)cyclohexanesulfonamide::US10981911, Example 141 Tyrosine-protein kinase JAK3 [512-1124] 4070 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493206&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143157 447119891 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026613 CS(C)(=O)=NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493207 2-((1r,4r)-4-(2-(((Dimethyl(oxo)-λ6-sulfanylidene)amino)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 142 Tyrosine-protein kinase JAK3 [512-1124] 383 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493207&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142944 447119892 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026617 FS(F)(F)(F)(F)c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493208 2-((1r,4r)-4-(2-(4-(Pentafluoro-λ6-sulfanyl)phenyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 143 Tyrosine-protein kinase JAK3 [512-1124] 1272 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493208&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142967 447119893 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026621 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1cn[nH]c1 493209 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-1H-pyrazole-4-carboxamide::US10981911, Example 144 Tyrosine-protein kinase JAK3 [512-1124] 376 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493209&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142934 447119894 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026625 COCCNC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493210 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(2-methoxyethyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 145 Tyrosine-protein kinase JAK3 [512-1124] 175 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493210&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143017 447119895 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026629 O=C(NCC1CCCCC1)OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493211 (1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl (cyclohexylmethyl)carbamate::US10981911, Example 146 Tyrosine-protein kinase JAK3 [512-1124] 319 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493211&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142738 447119896 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026633 CC(=O)N1CC(C1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493212 2-((1r,4r)-4-(2-(1-Acetylazetidin-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 147 Tyrosine-protein kinase JAK3 [512-1124] 1974 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493212&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142936 447119897 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026637 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493213 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzamide::US10981911, Example 148 Tyrosine-protein kinase JAK3 [512-1124] 767 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493213&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142920 447119898 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026641 OC[C@H]1CCCN1C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493214 2-((1r,4r)-4-(2-(2-((R)-2-(Hydroxymethyl)pyrrolidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 149 Tyrosine-protein kinase JAK3 [512-1124] 926 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493214&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142633 447119899 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026645 CC(C)C(\N)=N\OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493215 (Z*)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)isobutyrimidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 150 Tyrosine-protein kinase JAK3 [512-1124] 110 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493215&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142741 447119900 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026649 N\C(=N/OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C1CC1 493216 (Z*)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)cyclopropanecarboximidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 151 Tyrosine-protein kinase JAK3 [512-1124] 103 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493216&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143003 447119901 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026653 N\C(=N/OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C12CC3CC(CC(C3)C1)C2 493217 (3R,5R,7R,E*)-N′-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)adamantane-1-carboximidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 152 Tyrosine-protein kinase JAK3 [512-1124] 803 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493217&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143030 447119902 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026221 CC(C)(C)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493104 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-neopentylacetamide::US10981911, Example 44 Tyrosine-protein kinase JAK3 [512-1124] 52.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493104&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142878 447119789 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026225 Fc1ccc(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1 InChI=1S/C25H25FN6O/c26-18-5-1-17(2-6-18)14-29-23(33)13-22-31-21-15-30-25-20(10-12-28-25)24(21)32(22)19-7-3-16(4-8-19)9-11-27/h1-2,5-6,10,12,15-16,19H,3-4,7-9,13-14H2,(H,28,30)(H,29,33)/t16-,19- MMAFBZVPAFVVFX-RUCARUNLSA-N 50527406 CHEMBL4588333::US10981911, Example 45 Tyrosine-protein kinase JAK3 [512-1124] 183 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527406&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143120 440735988 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026229 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Oc1ccccc1 493106 Phenyl ((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)carbamate::US10981911, Example 46 Tyrosine-protein kinase JAK3 [512-1124] 214 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493106&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142706 447119791 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026233 O[C@H]1CC[C@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493107 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1S,4S)-4-hydroxycyclohexyl)acetamide::US10981911, Example 47 Tyrosine-protein kinase JAK3 [512-1124] 38.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493107&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142625 447119792 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026237 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccccc1 493108 N-Benzyl-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 48 Tyrosine-protein kinase JAK3 [512-1124] 193 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493108&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142406 447119793 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026241 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCCC1 493109 2-((1r,4r)-4-(2-(2-Oxo-2-(pyrrolidin-1-yl)ethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 49 Tyrosine-protein kinase JAK3 [512-1124] 249 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493109&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142627 447119794 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026245 OC1(CCN(C1)C(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493110 2-((1r,4r)-4-(2-(3-Hydroxy-3-phenylpyrrolidine-1-carbonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 50 Tyrosine-protein kinase JAK3 [512-1124] 99.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493110&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143117 447119795 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026249 Nc1ncc(cn1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493111 2-((1r,4r)-4-(2-(2-Aminopyrimidin-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 51 Tyrosine-protein kinase JAK3 [512-1124] 127 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493111&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142865 447119796 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026253 OC12CC3CC(C1)CC(C3)(C2)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493112 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1s,3r,5R,7S)-3-hydroxyadamantan-1-yl)acetamide::US10981911, Example 52 Tyrosine-protein kinase JAK3 [512-1124] 57.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493112&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142721 447119797 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026257 Nc1nccc(n1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493113 2-((1r,4r)-4-(2-(2-Aminopyrimidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 53 Tyrosine-protein kinase JAK3 [512-1124] 61.8 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493113&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143124 447119798 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026261 NC(=O)C12CCC(CC1)(C2)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493114 4-(2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamido)bicyclo[2.2.1]heptane-1-carboxamide::US10981911, Example 54 Tyrosine-protein kinase JAK3 [512-1124] 42.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493114&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142623 447119799 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026265 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC12CCC(CC#N)(CC1)C2 387827 N-(4-(Cyanomethyl)bicyclo[2.2.1]heptan-1-yl)-2-(1-((1r, 4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10294226, Compound Ex. 10::US10487083, Example 10::US10981911, Example 55::US11059823, Example 10 Tyrosine-protein kinase JAK3 [512-1124] 59.6 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387827&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611542 404856932 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026269 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1ncc[nH]1 InChI=1S/C19H17N7/c20-7-5-12-1-3-13(4-2-12)26-16-14-6-8-21-17(14)24-11-15(16)25-19(26)18-22-9-10-23-18/h6,8-13H,1-5H2/t12-,13- MPFVBVUCOVNCCC-JOCQHMNTSA-N 493116 2-((1r,4r)-4-(2-(1H-Imidazol-2-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 56 Tyrosine-protein kinase JAK3 [512-1124] 32.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493116&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297630 447119801 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026273 FC(F)(F)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C20H21F3N6O/c21-20(22,23)11-27-17(30)9-16-28-15-10-26-19-14(6-8-25-19)18(15)29(16)13-3-1-12(2-4-13)5-7-24/h6,8,10,12-13H,1-5,9,11H2,(H,25,26)(H,27,30)/t12-,13- JNUDIJJVTYHAPN-JOCQHMNTSA-N 50527410 CHEMBL4439418::US10981911, Example 57 Tyrosine-protein kinase JAK3 [512-1124] 69.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527410&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142885 440735992 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026277 NC(=O)C12CCC(CC1)(CC2)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C27H33N7O2/c28-13-5-17-1-3-18(4-2-17)34-21(32-20-16-31-24-19(23(20)34)6-14-30-24)15-22(35)33-27-10-7-26(8-11-27,9-12-27)25(29)36/h6,14,16-18H,1-5,7-12,15H2,(H2,29,36)(H,30,31)(H,33,35)/t17-,18-,26?,27? VGQGFYCOZCNACG-RWSJPRBTSA-N 50527409 CHEMBL4447497::US10981911, Example 58 Tyrosine-protein kinase JAK3 [512-1124] 31.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527409&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142423 440735991 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026657 N\C(CN1CCCCC1)=N/OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493218 (Z*)—N′-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)-2-(piperidin-1-yl)acetimidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 153 Tyrosine-protein kinase JAK3 [512-1124] 512 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493218&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142952 447119903 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026661 CC(C)(C)COC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493219 Neopentyl ((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)carbamate::US10981911, Example 154 Tyrosine-protein kinase JAK3 [512-1124] 408 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493219&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142943 447119904 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026665 O=C(NCC1CCCCC1)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493220 1-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-3-(cyclohexylmethyl)urea::US10981911, Example 155 Tyrosine-protein kinase JAK3 [512-1124] 368 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493220&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143148 447119905 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026669 N=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C12CC3CC(CC(C3)C1)C2 493221 (3R,5R,7R)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)adamantane-1-carboximidamide::US10981911, Example 156 Tyrosine-protein kinase JAK3 [512-1124] 1325 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493221&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143106 447119906 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026673 O=C(CCC#N)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493222 3-Cyano-N-((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)propanamide::US10981911, Example 157 Tyrosine-protein kinase JAK3 [512-1124] 1110 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493222&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143009 447119907 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026677 CC(C)(C)OC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493223 US10981911, Example 158::tert-Butyl ((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)carbamate Tyrosine-protein kinase JAK3 [512-1124] 630 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493223&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142745 447119908 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026681 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)C1CNC1 493224 2-((1r,4r)-4-(2-(Azetidin-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 159 Tyrosine-protein kinase JAK3 [512-1124] 1230 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493224&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143155 447119909 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026685 O=C(CC#N)N1CC(C1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493225 3-(3-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)azetidin-1-yl)-3-oxopropanenitrile::US10981911, Example 160 Tyrosine-protein kinase JAK3 [512-1124] 1078 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493225&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142951 447119910 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026689 COCCNC(=O)OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493226 (1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl (2-methoxyethyl)carbamate::US10981911, Example 161 Tyrosine-protein kinase JAK3 [512-1124] 260 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493226&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142467 447119911 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026693 C[S@](=O)(=NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493227 2-((1r,4r)-4-(2-((((R)-Methyl(oxo)(phenyl)-λ6-sulfanylidene)amino)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 162 Tyrosine-protein kinase JAK3 [512-1124] 2265 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493227&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 156570859 447119912 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026697 C[S@@](=O)(=NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493228 2-((1r,4r)-4-(2-((((S)-methyl(oxo)(phenyl)-λ6-sulfanylidene)amino)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 163 Tyrosine-protein kinase JAK3 [512-1124] 864 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493228&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 153445219 447119913 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026701 CC(=O)N1CCC(CC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493229 2-((1r,4r)-4-(2-(1-Acetylpiperidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 164 Tyrosine-protein kinase JAK3 [512-1124] 2149 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493229&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142975 447119914 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026705 O=c1onc(C2CC2)n1Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493230 2-((1r,4r)-4-(2-((3-Cyclopropyl-5-oxo-1,2,4-oxadiazol-4(5H)-yl)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 165 Tyrosine-protein kinase JAK3 [512-1124] 2703 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493230&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143149 447119915 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026709 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cnn(Cc2cocn2)c1 493233 2-((1r,4r)-4-(2-(1-(Oxazol-4-ylmethyl)-1H-pyrazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 166 Tyrosine-protein kinase JAK3 [512-1124] 144 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493233&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142733 447119918 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026713 C[Si](C)(C)[C@H]1CC[C@@H](CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493234 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1r,4r)-4-(trimethylsilyl)cyclohexyl)acetamide::US10981911, Example 167 Tyrosine-protein kinase JAK3 [512-1124] 468 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493234&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 153445216 447119919 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026717 CC(C)(O)CN1CCC(CC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493235 2-((1r,4r)-4-(2-(1-(2-Hydroxy-2-methylpropyl)piperidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 168 Tyrosine-protein kinase JAK3 [512-1124] 1570 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493235&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142980 447119920 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026721 O=C(c1ccc(cc1)C#C)c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493236 2-((1r,4r)-4-(2-(4-(4-Ethynylbenzoyl)phenyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 169 Tyrosine-protein kinase JAK3 [512-1124] 5640 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493236&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142958 447119921 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026725 O=C(c1ccc(CCc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)c1ccc(cc1)C#C 493237 2-((1r,4r)-4-(2-(4-(4-Ethynylbenzoyl)phenethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 170 Tyrosine-protein kinase JAK3 [512-1124] >12500 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493237&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143163 447119922 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026729 CC(C)NC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493238 1-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-3-isopropylurea::US10981911, Example 171 Tyrosine-protein kinase JAK3 [512-1124] 211 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493238&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142739 447119923 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026733 CC(C)NC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493239 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-isopropyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 172 Tyrosine-protein kinase JAK3 [512-1124] 3060 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493239&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142687 447119924 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026737 COCCCNC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493240 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(3-methoxypropyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 173 Tyrosine-protein kinase JAK3 [512-1124] 732 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493240&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142457 447119925 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026741 O=C(NCC1CC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493241 1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-N-(cyclopropylmethyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 174 Tyrosine-protein kinase JAK3 [512-1124] 604 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493241&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143159 447119926 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026745 O=C(NC1CC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493242 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-cyclopropyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 175 Tyrosine-protein kinase JAK3 [512-1124] 839 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493242&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143022 447119927 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026749 COC1CCN(CC1)C(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493243 2-((1r,4r)-4-(2-(4-Methoxypiperidine-1-carbonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 176 Tyrosine-protein kinase JAK3 [512-1124] 3252 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493243&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143170 447119928 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026753 O=C(N1CCC(CC1)C#N)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493244 1-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carbonyl)piperidine-4-carbonitrile::US10981911, Example 177 Tyrosine-protein kinase JAK3 [512-1124] 2374 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493244&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143154 447119929 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026757 O=C(NC1CCOCC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493245 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(tetrahydro-2H-pyran-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 178 Tyrosine-protein kinase JAK3 [512-1124] 1313 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493245&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142682 447119930 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026761 COCC(C)NC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493246 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(1-methoxypropan-2-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 179 Tyrosine-protein kinase JAK3 [512-1124] 641 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493246&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142978 447119931 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026765 O=C(N1CCOCC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493247 2-((1r,4r)-4-(2-(Morpholine-4-carbonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 180 Tyrosine-protein kinase JAK3 [512-1124] 2294 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493247&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142470 447119932 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026769 OC1CCN(CC1)C(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493248 2-((1r,4r)-4-(2-(4-Hydroxypiperidine-1-carbonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 181 Tyrosine-protein kinase JAK3 [512-1124] 6301 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493248&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143024 447119933 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026281 CC(C)(O)CCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493119 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(3-hydroxy-3-methylbutyl)acetamide::US10981911, Example 59 Tyrosine-protein kinase JAK3 [512-1124] 122 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493119&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142662 447119804 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026285 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1cc[nH]n1 InChI=1S/C19H17N7/c20-8-5-12-1-3-13(4-2-12)26-17-14-6-9-21-18(14)22-11-16(17)24-19(26)15-7-10-23-25-15/h6-7,9-13H,1-5H2/b19-15-/t12-,13- SBCIUJCFNDKUQC-KHJRLVIRSA-N 493120 2-((1r,4r)-4-(2-(1H-Pyrazol-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 60 Tyrosine-protein kinase JAK3 [512-1124] 72.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493120&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297634 447119805 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026289 CC(C)C(\NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)=N\O 493121 EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-hydroxyisobutyrimidamide::US10981911, Example 61 Tyrosine-protein kinase JAK3 [512-1124] 219 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493121&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143121 447119806 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026293 CC(C)CN1CCC(CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C27H37N7O/c1-18(2)17-33-13-9-20(10-14-33)31-25(35)15-24-32-23-16-30-27-22(8-12-29-27)26(23)34(24)21-5-3-19(4-6-21)7-11-28/h8,12,16,18-21H,3-7,9-10,13-15,17H2,1-2H3,(H,29,30)(H,31,35)/t19-,21- SFRSQEVTJXTTHI-XUTJKUGGSA-N 50527404 CHEMBL4514898::US10981911, Example 62 Tyrosine-protein kinase JAK3 [512-1124] 30.6 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527404&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142442 440735986 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026297 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1nn[nH]n1 InChI=1S/C17H15N9/c18-7-5-10-1-3-11(4-2-10)26-14-12-6-8-19-15(12)20-9-13(14)21-17(26)16-22-24-25-23-16/h6,8-11H,1-5H2/t10-,11- NEQXJZYAXUFTEU-XYPYZODXSA-N 493123 2-((1r,4r)-4-(2-(2H-Tetrazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 63 Tyrosine-protein kinase JAK3 [512-1124] 57.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493123&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297629 447119808 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026301 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1cn[nH]c1 493124 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1H-pyrazol-4-yl)acetamide::US10981911, Example 64 Tyrosine-protein kinase JAK3 [512-1124] 51.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493124&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142644 447119809 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026305 CC1(C)CCC(CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493125 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4,4-dimethylcyclohexyl)acetamide::US10981911, Example 65 Tyrosine-protein kinase JAK3 [512-1124] 81.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493125&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142841 447119810 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026309 CN1CCC(CC1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493126 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1-methylpiperidin-4-yl)acetamide::US10981911, Example 66 Tyrosine-protein kinase JAK3 [512-1124] 18.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493126&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143131 447119811 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026313 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCS(=O)(=O)CC1 493127 2-((1r,4r)-4-(2-(2-(1,1-Dioxidothiomorpholino)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 67 Tyrosine-protein kinase JAK3 [512-1124] 121 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493127&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193332 447119812 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026317 OCc1ccc(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1 493128 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(hydroxymethyl)benzyl)acetamide::US10981911, Example 68 Tyrosine-protein kinase JAK3 [512-1124] 180 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493128&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142449 447119813 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026321 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC1CCCCC1 493129 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(cyclohexylmethyl)acetamide::US10981911, Example 69 Tyrosine-protein kinase JAK3 [512-1124] 111 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493129&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142652 447119814 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026325 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccccc1 493130 1-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-3-phenylurea and its Trifluoroacetate Salt::US10981911, Example 70 Tyrosine-protein kinase JAK3 [512-1124] 108 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493130&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142452 447119815 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026329 COC(C)(C)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493131 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-methoxy-2-methylpropyl)acetamide::US10981911, Example 71 Tyrosine-protein kinase JAK3 [512-1124] 54.2 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493131&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142928 447119816 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026333 COCC\C(N)=N\OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493132 (Z*)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)-3-methoxypropanimidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 72 Tyrosine-protein kinase JAK3 [512-1124] 181 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493132&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142719 447119817 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026337 OCC1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493133 2-((1r,4r)-4-(2-(2-(4-(Hydroxymethyl)piperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 73 Tyrosine-protein kinase JAK3 [512-1124] 199 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493133&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142950 447119818 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026341 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1cc[nH]n1 387828 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(1H-pyrazol-3-yl)acetamide::US10294226, Compound Ex. 11::US10487083, Example 11::US10981911, Example 74::US11059823, Example 11 Tyrosine-protein kinase JAK3 [512-1124] 30.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387828&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611570 404856933 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026345 CC1CC(C)CC(C1)NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493135 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(3,5-dimethylcyclohexyl)acetamide::US10981911, Example 75 Tyrosine-protein kinase JAK3 [512-1124] 62.3 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493135&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142653 447119820 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026349 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)C1CCN(CC1)c1ccc(cc1)C#N 493136 4-(4-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)piperidin-1-yl)benzonitrile::US10981911, Example 76 Tyrosine-protein kinase JAK3 [512-1124] 1214 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493136&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142430 447119821 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026353 O=S(=O)(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493137 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzenesulfonamide::US10981911, Example 77 Tyrosine-protein kinase JAK3 [512-1124] 1915 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493137&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142880 447119822 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026357 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CC2CCC1C2 493138 N-((1S,4R)-Bicyclo[2.2.1]heptan-2-yl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 78 Tyrosine-protein kinase JAK3 [512-1124] 69.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493138&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142431 447119823 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026361 FC(F)Oc1ccc(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1 493139 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(difluoromethoxy)benzyl)acetamide::US10981911, Example 79 Tyrosine-protein kinase JAK3 [512-1124] 223 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493139&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142668 447119824 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026365 OC1(CNC(=O)c2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)COC1 493140 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-((3-hydroxyoxetan-3-yl)methyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 80 Tyrosine-protein kinase JAK3 [512-1124] 89.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493140&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142830 447119825 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026369 Cc1cc([nH]n1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C20H19N7/c1-12-10-16(26-25-12)20-24-17-11-23-19-15(7-9-22-19)18(17)27(20)14-4-2-13(3-5-14)6-8-21/h7,9-11,13-14H,2-6H2,1H3/b20-16+/t13-,14- QJMUSAOGWCJFAW-CRPVRQRCSA-N 493141 2-((1r,4r)-4-(2-(3-Methyl-1H-pyrazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 81 Tyrosine-protein kinase JAK3 [512-1124] 117 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493141&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137297626 447119826 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026373 O=C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccc(cc1)C#N 493142 4-Cyano-N-((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzamide::US10981911, Example 82 Tyrosine-protein kinase JAK3 [512-1124] 189 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493142&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142715 447119827 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026377 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CCSCC1 493143 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(tetrahydro-2H-thiopyran-4-yl)acetamide::US10981911, Example 83 Tyrosine-protein kinase JAK3 [512-1124] 30.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493143&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142894 447119828 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026381 CN1CCC(CC1)NC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493144 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(1-methylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 84 Tyrosine-protein kinase JAK3 [512-1124] 1118 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493144&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142727 447119829 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026385 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CC1 387829 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclopropyl)methyl)acetamide::US10294226, Compound Ex. 12::US10487083, Example 12::US10981911, Example 85::US11059823, Example 12 Tyrosine-protein kinase JAK3 [512-1124] 68.2 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=387829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=387829&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611598 404856934 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026389 CC(=N)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493146 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)acetimidamide::US10981911, Example 86 Tyrosine-protein kinase JAK3 [512-1124] 2269 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493146&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142445 447119831 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026393 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCC(Cc2ccccc2)CC1 493147 2-((1r,4r)-4-(2-(2-(4-Benzylpiperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile and its Trifluoroacetic Acid Salt::US10981911, Example 87 Tyrosine-protein kinase JAK3 [512-1124] 274 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493147&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142917 447119832 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026397 OC1(CCN(CC1)C(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccn1 493148 2-((1r,4r)-4-(2-(4-Hydroxy-4-(pyridin-2-yl)piperidine-1-carbonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 88 Tyrosine-protein kinase JAK3 [512-1124] 541 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493148&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142956 447119833 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026773 CCOC(=O)Cn1cc(cn1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493252 Ethyl 2-(4-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-1H-pyrazol-1-yl)acetate::US10981911, Example 182 Tyrosine-protein kinase JAK3 [512-1124] 276 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493252&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143116 447119937 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026777 Cc1nc(C)c(o1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493253 2-((1r,4r)-4-(2-(2,4-dimethyloxazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 183 Tyrosine-protein kinase JAK3 [512-1124] 645 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493253&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142663 447119938 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026781 Cc1nc(C)c(s1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493254 2-((1r,4r)-4-(2-(2,4-dimethylthiazol-5-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 184 Tyrosine-protein kinase JAK3 [512-1124] 1230 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493254&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143139 447119939 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026785 O=C(Cn1cc(cn1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NC1CC1 493255 2-(4-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-1H-pyrazol-1-yl)-N-cyclopropylacetamide::US10981911, Example 185 Tyrosine-protein kinase JAK3 [512-1124] 150 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493255&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142999 447119940 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026789 Nc1ncccc1-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493256 2-((1r,4r)-4-(2-(2-aminopyridin-3-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 186 Tyrosine-protein kinase JAK3 [512-1124] 4647 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493256&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142749 447119941 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026793 CC(C)(O)Cn1cc(cn1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493257 2-((1r,4r)-4-(2-(1-(2-Hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 187 Tyrosine-protein kinase JAK3 [512-1124] 180 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493257&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142959 447119942 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026797 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]cc(Cl)c3c2n1[C@H]1CC[C@H](CC#N)CC1 493258 2-(8-chloro-1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10981911, Example 188 Tyrosine-protein kinase JAK3 [512-1124] 13.1 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493258&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142743 447119943 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026801 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]cc(Br)c3c2n1[C@H]1CC[C@H](CC#N)CC1 493259 2-(8-bromo-1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10981911, Example 189 Tyrosine-protein kinase JAK3 [512-1124] 16.6 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493259&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143164 447119944 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026805 Cc1c[nH]c2ncc3nc(CC(=O)NCC(C)(C)O)n([C@H]4CC[C@H](CC#N)CC4)c3c12 493260 2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-8-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10981911, Example 190 Tyrosine-protein kinase JAK3 [512-1124] 102 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493260&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142973 447119945 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026809 Cc1cc2c(ncc3nc(CC(=O)NCC(C)(C)O)n([C@H]4CC[C@H](CC#N)CC4)c23)[nH]1 493261 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-7-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide::US10981911, Example 191 Tyrosine-protein kinase JAK3 [512-1124] 1337 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493261&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142468 447119946 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026813 COCCOCCOCCOCCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493262 2-((1r,4r)-4-(2-(2, 5,8,11-Tetraoxatridecan-13-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 192 Tyrosine-protein kinase JAK3 [512-1124] 1119 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493262&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143179 447119947 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026817 NCCOCCOCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493263 N-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 193 Tyrosine-protein kinase JAK3 [512-1124] 69.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493263&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142963 447119948 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026821 COCCOCCOCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493264 2-((1r,4r)-4-(2-((2-(2-methoxyethoxy)ethoxy)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 194 Tyrosine-protein kinase JAK3 [512-1124] 1462 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493264&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142742 447119949 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026825 OC[C@@H]1CCCN1C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493265 2-((1S,4r)-4-(2-(2-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 195 Tyrosine-protein kinase JAK3 [512-1124] 294 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493265&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193337 447119950 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026829 O=C(NC12CC3CC(CC(C3)C1)C2)OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493267 (1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl (3S,5S,7S)-adamantan-1-ylcarbamate::US10981911, Example 196 Tyrosine-protein kinase JAK3 [512-1124] 660 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493267&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146213271 447119952 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026401 CNc1nccc(n1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493149 2-((1r,4r)-4-(2-(2-(Methylamino)pyrimidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 89 Tyrosine-protein kinase JAK3 [512-1124] 60.6 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493149&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142641 447119834 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026405 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCCCC1 493150 2-((1r,4r)-4-(2-(2-Oxo-2-(piperidin-1-yl)ethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 90 Tyrosine-protein kinase JAK3 [512-1124] 85.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493150&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193347 447119835 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026409 CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493151 2-((1r,4r)-4-(2-(4′-(Methylsulfonyl)-[1,1′-biphenyl]-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 91 Tyrosine-protein kinase JAK3 [512-1124] 851 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493151&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142447 447119836 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026413 O=C(c1ccccc1)c1ccc(cc1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493152 2-((1r,4r)-4-(2-(4-Benzoylphenyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 92 Tyrosine-protein kinase JAK3 [512-1124] 874 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493152&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142459 447119837 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026417 CC(C)(O)C1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493154 2-((1r,4r)-4-(2-(2-(4-(2-Hydroxypropan-2-yl)piperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 93 Tyrosine-protein kinase JAK3 [512-1124] 181 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493154&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142927 447119839 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026421 O=C(CC1CC1)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(13-25-20(29)11-15-1-2-15)27-18-12-26-22-17(21(18)28)8-10-24-22/h8,10,12,14-16H,1-7,11,13H2,(H,24,26)(H,25,29)/t14-,16- NIEWQWZIFKHKCR-KOMQPUFPSA-N 50527408 CHEMBL4437638::US10981911, Example 94 Tyrosine-protein kinase JAK3 [512-1124] 264 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527408&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142656 440735990 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026425 O\N=C(/CC1CCCCC1)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493156 (EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-2-cyclohexyl-N-hydroxyacetimidamide::US10981911, Example 95 Tyrosine-protein kinase JAK3 [512-1124] 18.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493156&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379921 447119841 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026429 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1ccc(cc1)C#N 493157 4-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)benzonitrile::US10981911, Example 96 Tyrosine-protein kinase JAK3 [512-1124] 460 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493157&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142462 447119842 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026433 O=S(=O)(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccc(cc1)C#N 493158 4-Cyano-N-((1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)benzenesulfonamide::US10981911, Example 97 Tyrosine-protein kinase JAK3 [512-1124] 3882 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493158&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142732 447119843 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026437 CSc1nccc(n1)-c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493159 2-((1r,4r)-4-(2-(2-(Methylthio)pyrimidin-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 98 Tyrosine-protein kinase JAK3 [512-1124] 117 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493159&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142675 447119844 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026441 C[Si](C)(C)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493160 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((trimethyl silyl)methyl)acetamide::US10981911, Example 99 Tyrosine-protein kinase JAK3 [512-1124] 276 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493160&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 153445223 447119845 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026445 C[Si](C)(C)C1CCC(CC1)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493161 2-((1r,4r)-4-(2-(4-(Trimethylsilyl)cyclohexyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile as its Trifluoroacetic Acid::US10981911, Example 100 Tyrosine-protein kinase JAK3 [512-1124] >6250 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493161&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379906 447119846 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026449 CC(C)(C)C\C(NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)=N\O 493162 (EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-hydroxy-3,3-dimethylbutanimidamide::US10981911, Example 101 Tyrosine-protein kinase JAK3 [512-1124] 182 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493162&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 142379880 447119847 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026453 OC(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)c1ccccc1 493163 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-phenylethyl)acetamide::US10981911, Example 102 Tyrosine-protein kinase JAK3 [512-1124] 201 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493163&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193389 447119848 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026833 COC1CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493268 2-((1r,4r)-4-(2-(2-(4-Methoxypiperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile and its Trifluoroacetic Acid Salt::US10981911, Example 197 Tyrosine-protein kinase JAK3 [512-1124] 132 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493268&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193335 447119953 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026837 CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493269 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-methylacetamide as its Trifluoroacetic Acid Salt::US10981911, Example 198 Tyrosine-protein kinase JAK3 [512-1124] 24.4 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493269&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142708 447119954 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026841 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCC12CC3CC(CC(C3)C1)C2 493278 N-((3R,5R,7R)-Adamantan-1-ylmethyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide as its Trifluoroacetic Acid Salt::US10981911, Example 199 Tyrosine-protein kinase JAK3 [512-1124] 109 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493278&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143034 447119963 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026845 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1ccc(cc1)C#N 493279 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-cyanophenyl)acetamide::US10981911, Example 200 Tyrosine-protein kinase JAK3 [512-1124] 13.7 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493279&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142692 447119964 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026849 NC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493281 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide Trifluoracetic Acid::US10981911, Example 201 Tyrosine-protein kinase JAK3 [512-1124] 47.5 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493281&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193371 447119966 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026853 CC(C)(C)OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493284 2-((1r,4r)-4-(2-(tert-Butoxymethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile and its Trifluoroacetic Acid Salt::US10981911, Example 202 Tyrosine-protein kinase JAK3 [512-1124] 1040 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493284&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142665 447119969 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026857 O=c1onc(-c2ccccc2)n1Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493286 2-((1r,4r)-4-(2-((5-Oxo-3-phenyl-1,2,4-oxadiazol-4(5H)-yl)methyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 203 Tyrosine-protein kinase JAK3 [512-1124] 4675 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493286&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193350 447119971 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026861 O\N=C(\NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C1CCCCC1 493287 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N′-hydroxycyclohexanecarboximidamide::US10981911, Example 204 Tyrosine-protein kinase JAK3 [512-1124] 427 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493287&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143172 447119972 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026865 O=C(Cc1nc2cnc3[nH]ccc3c2n1C12CCC(CC#N)(CC1)CC2)N1CCCCC1 InChI=1S/C25H30N6O/c26-12-11-24-5-8-25(9-6-24,10-7-24)31-20(16-21(32)30-14-2-1-3-15-30)29-19-17-28-23-18(22(19)31)4-13-27-23/h4,13,17H,1-3,5-11,14-16H2,(H,27,28) IBCCFPBZTDBKMM-UHFFFAOYSA-N 493288 2-(4-(2-(2-Oxo-2-(piperidin-1-yl)ethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)bicyclo[2.2.2]octan-1-yl)acetonitrile::US10981911, Example 205 Tyrosine-protein kinase JAK3 [512-1124] 439 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493288&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126036 447119973 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026869 NC(=O)Cc1nc2cnc3[nH]ccc3c2n1C12CCC(CC#N)(CC1)CC2 InChI=1S/C20H22N6O/c21-9-8-19-2-5-20(6-3-19,7-4-19)26-16(11-15(22)27)25-14-12-24-18-13(17(14)26)1-10-23-18/h1,10,12H,2-8,11H2,(H2,22,27)(H,23,24) JXIQODSZYMICLN-UHFFFAOYSA-N 493289 2-(1-(4-(Cyanomethyl)bicyclo[2.2.2]octan-1-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide::US10981911, Example 206 Tyrosine-protein kinase JAK3 [512-1124] 881 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493289&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126499 447119974 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026873 O=C(Cc1nc2cnc3[nH]ccc3c2n1C12CCC(CC#N)(CC1)CC2)Nc1ccccc1 InChI=1S/C26H26N6O/c27-14-13-25-7-10-26(11-8-25,12-9-25)32-21(16-22(33)30-18-4-2-1-3-5-18)31-20-17-29-24-19(23(20)32)6-15-28-24/h1-6,15,17H,7-13,16H2,(H,28,29)(H,30,33) DHPKQSLHIJVITH-UHFFFAOYSA-N 493290 2-(1-(4-(Cyanomethyl)bicyclo[2.2.2]octan-1-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-phenylacetamide::US10981911, Example 207 Tyrosine-protein kinase JAK3 [512-1124] 375 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493290&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135125413 447119975 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026877 O=C(Cc1nc2cnc3[nH]ccc3c2n1C12CCC(CC#N)(CC1)CC2)NCC1CCCCC1 InChI=1S/C27H34N6O/c28-14-13-26-7-10-27(11-8-26,12-9-26)33-22(16-23(34)30-17-19-4-2-1-3-5-19)32-21-18-31-25-20(24(21)33)6-15-29-25/h6,15,18-19H,1-5,7-13,16-17H2,(H,29,31)(H,30,34) XGRCANVTIMWGDG-UHFFFAOYSA-N 493291 2-(1-(4-(Cyanomethyl)bicyclo[2.2.2]octan-1-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(cyclohexylmethyl)acetamide::US10981911, Example 208 Tyrosine-protein kinase JAK3 [512-1124] 536 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493291&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126488 447119976 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026881 CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C12CCC(CC#N)(CC1)CC2 InChI=1S/C21H24N6O/c1-23-17(28)12-16-26-15-13-25-19-14(2-11-24-19)18(15)27(16)21-6-3-20(4-7-21,5-8-21)9-10-22/h2,11,13H,3-9,12H2,1H3,(H,23,28)(H,24,25) LRWVMOVPNZZPFN-UHFFFAOYSA-N 493292 2-(1-(4-(Cyanomethyl)bicyclo[2.2.2]octan-1-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-methylacetamide::US10981911, Example 209 Tyrosine-protein kinase JAK3 [512-1124] 604 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493292&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135126088 447119977 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026457 O\N=C(\Cc1ccccc1)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493164 (EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N-hydroxy-2-phenylacetimidamide::US10981911, Example 103 Tyrosine-protein kinase JAK3 [512-1124] 459 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493164&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142965 447119849 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026461 OC(c1ccc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)(C(F)(F)F)C(F)(F)F 493165 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)acetamide::US10981911, Example 104 Tyrosine-protein kinase JAK3 [512-1124] 298 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493165&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193342 447119850 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026465 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCC(CC1)C#N 493166 1-(2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetyl)piperidine-4-carbonitrile::US10981911, Example 105 Tyrosine-protein kinase JAK3 [512-1124] 204 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493166&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142670 447119851 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026469 OCC(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493167 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2,3-dihydroxypropyl)acetamide::US10981911, Example 106 Tyrosine-protein kinase JAK3 [512-1124] 149 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493167&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 146193359 447119852 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026473 FC1(F)CCN(CC1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493168 2-((1r,4r)-4-(2-(2-(4,4-Difluoropiperidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 107 Tyrosine-protein kinase JAK3 [512-1124] 142 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493168&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143113 447119853 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026477 CCOP(=O)(Cc1ccc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)cc1)OCC 493169 Diethyl 4-(2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamido)benzylphosphonate::US10981911, Example 108 Tyrosine-protein kinase JAK3 [512-1124] 32.9 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493169&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142889 447119854 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026481 O=C(Nc1ccccc1)OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493170 (1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl Phenylcarbamate::US10981911, Example 109 Tyrosine-protein kinase JAK3 [512-1124] 135 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493170&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142678 447119855 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026485 O\N=C(/NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)C1CC1 493171 (EZ)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-N′-hydroxycyclopropanecarboximidamide::US10981911, Example 110 Tyrosine-protein kinase JAK3 [512-1124] 416 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493171&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143140 447119856 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026489 O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)Nc1cccnc1 493172 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(pyridin-3-yl)acetamide::US10981911, Example 111 Tyrosine-protein kinase JAK3 [512-1124] 68.0 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493172&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142892 447119857 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026493 N\C(CC1CC1)=N/OCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493173 (Z)—N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methoxy)-2-cyclopropylacetimidamide; the Structure being the (Z) or (E) Isomer, and the (Z) Notation and its Corresponding Structure Below is Chosen Arbitrarily::US10981911, Example 112 Tyrosine-protein kinase JAK3 [512-1124] 161 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493173&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135143109 447119858 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026497 COCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493174 2-((1r,4r)-4-(2-(Methoxymethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile::US10981911, Example 113 Tyrosine-protein kinase JAK3 [512-1124] 322 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493174&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142734 447119859 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026501 OCCNC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493175 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(2-hydroxyethyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 114 Tyrosine-protein kinase JAK3 [512-1124] 102 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493175&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142861 447119860 C04080 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026505 N#CC[C@H]1CC[C@@H](CC1)n1c(nc2cnc3[nH]ccc3c12)-c1ccc(nc1)C#N 493176 5-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)picolinonitrile::US10981911, Example 115 Tyrosine-protein kinase JAK3 [512-1124] 754 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493176&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142458 447119861 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026509 CC(C)(O)CC(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493177 N-((1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)methyl)-3-hydroxy-3-methylbutanamide::US10981911, Example 116 Tyrosine-protein kinase JAK3 [512-1124] 1191 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493177&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142716 447119862 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1026513 CC(C)(O)CNC(=O)c1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 493178 1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-N-(2-hydroxy-2-methylpropyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2-carboxamide::US10981911, Example 117 Tyrosine-protein kinase JAK3 [512-1124] 273 US Patent 10.7270/Q27P92G6 aid1805481 US10981911 Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=493178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=493178&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 135142456 447119863 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057977 Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N InChI=1S/C17H18N4/c1-11-20-16-7-6-15-14(8-9-19-15)17(16)21(11)13-4-2-12(10-18)3-5-13/h6-9,12-13,19H,2-5H2,1H3 RIKRKORHVRUSHA-UHFFFAOYSA-N 505104 US11066406, A Tyrosine-protein kinase JAK3 [512-1124] 12.4 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505104&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 162370549 459090327 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057981 OCc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N InChI=1S/C17H18N4O/c18-9-11-1-3-12(4-2-11)21-16(10-22)20-15-6-5-14-13(17(15)21)7-8-19-14/h5-8,11-12,19,22H,1-4,10H2 CDNSIWIDKULTPH-UHFFFAOYSA-N 505105 US11066406, B Tyrosine-protein kinase JAK3 [512-1124] 13.4 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505105&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 162370550 459090328 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057985 C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N 505106 US11066406, C Tyrosine-protein kinase JAK3 [512-1124] 49.7 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505106&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 162370551 459090329 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057989 CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1 InChI=1S/C22H28N6O2/c1-22(2,30)13-26-19(29)11-18-27-17-12-25-21-16(8-10-24-21)20(17)28(18)15-5-3-14(4-6-15)7-9-23/h8,10,12,14-15,30H,3-7,11,13H2,1-2H3,(H,24,25)(H,26,29) NJKMSBSVJSQUBU-UHFFFAOYSA-N 505107 US11066406, Ex. 1 Tyrosine-protein kinase JAK3 [512-1124] 92.2 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505107&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611548 459090330 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057993 N#CCC1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1 InChI=1S/C19H19N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2,(H,21,24)(H,22,23) GJBSQXREQHZZIS-UHFFFAOYSA-N 505108 US11066406, Ex. 2 Tyrosine-protein kinase JAK3 [512-1124] 33.9 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505108&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 137279255 459090331 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1057997 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCC1CC1 InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(11-20(29)25-12-15-1-2-15)27-18-13-26-22-17(21(18)28)8-10-24-22/h8,10,13-16H,1-7,11-12H2,(H,24,26)(H,25,29) ZGWBKVUBESXZAN-UHFFFAOYSA-N 505109 US11066406, Ex. 3 Tyrosine-protein kinase JAK3 [512-1124] 82.8 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505109&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611606 459090332 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058001 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCCC#N InChI=1S/C21H23N7O/c22-8-1-10-24-19(29)12-18-27-17-13-26-21-16(7-11-25-21)20(17)28(18)15-4-2-14(3-5-15)6-9-23/h7,11,13-15H,1-6,10,12H2,(H,24,29)(H,25,26) DZYJQAKCPQYEKD-UHFFFAOYSA-N 505110 US11066406, Ex. 4 Tyrosine-protein kinase JAK3 [512-1124] 96.2 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505110&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611545 459090333 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058005 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC1CCOCC1 InChI=1S/C23H28N6O2/c24-9-5-15-1-3-17(4-2-15)29-20(13-21(30)27-16-7-11-31-12-8-16)28-19-14-26-23-18(22(19)29)6-10-25-23/h6,10,14-17H,1-5,7-8,11-13H2,(H,25,26)(H,27,30) MHXZXPSUUPWZDU-UHFFFAOYSA-N 505111 US11066406, Ex. 5 Tyrosine-protein kinase JAK3 [512-1124] 23.1 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505111&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611547 459090334 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058009 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1 InChI=1S/C24H30N6O2/c25-10-9-24(7-2-1-3-8-24)30-20(14-21(31)27-15-17-5-12-32-13-6-17)29-19-16-28-23-18(22(19)30)4-11-26-23/h4,11,16-17H,1-3,5-9,12-15H2,(H,26,28)(H,27,31) VCNGELAFKHCXSO-UHFFFAOYSA-N 505112 US11066406, Ex. 6 Tyrosine-protein kinase JAK3 [512-1124] 28.2 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505112&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 162370552 459090335 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058013 CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N InChI=1S/C23H27N7O/c1-23(2,13-25)14-28-20(31)11-19-29-18-12-27-22-17(8-10-26-22)21(18)30(19)16-5-3-15(4-6-16)7-9-24/h8,10,12,15-16H,3-7,11,14H2,1-2H3,(H,26,27)(H,28,31) CRBPNYKHFXDNRW-UHFFFAOYSA-N 505113 US11066406, Ex. 7 Tyrosine-protein kinase JAK3 [512-1124] 98.4 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505113&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611580 459090336 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058017 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CCC1 InChI=1S/C23H28N6O2/c24-10-6-15-2-4-16(5-3-15)29-19(12-20(30)27-14-23(31)8-1-9-23)28-18-13-26-22-17(21(18)29)7-11-25-22/h7,11,13,15-16,31H,1-6,8-9,12,14H2,(H,25,26)(H,27,30) PLIGCLLCCNAPHR-UHFFFAOYSA-N 505114 US11066406, Ex. 8 Tyrosine-protein kinase JAK3 [512-1124] 75.6 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505114&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611549 459090337 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058021 Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1 InChI=1S/C22H24N8O/c1-29-13-15(11-26-29)27-20(31)10-19-28-18-12-25-22-17(7-9-24-22)21(18)30(19)16-4-2-14(3-5-16)6-8-23/h7,9,11-14,16H,2-6,10H2,1H3,(H,24,25)(H,27,31) ABFZHUCLMXPRPZ-UHFFFAOYSA-N 505115 US11066406, Ex. 9 Tyrosine-protein kinase JAK3 [512-1124] 79.9 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505115&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611573 459090338 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058025 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC12CCC(CC#N)(CC1)C2 InChI=1S/C27H31N7O/c28-12-5-18-1-3-19(4-2-18)34-22(32-21-16-31-25-20(24(21)34)6-14-30-25)15-23(35)33-27-9-7-26(17-27,8-10-27)11-13-29/h6,14,16,18-19H,1-5,7-11,15,17H2,(H,30,31)(H,33,35) OEEIOJZJNUSVKZ-UHFFFAOYSA-N 505116 US11066406, Ex. 10 Tyrosine-protein kinase JAK3 [512-1124] 87.5 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505116&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611542 459090339 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058029 O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)Nc1cc[nH]n1 InChI=1S/C21H22N8O/c22-8-5-13-1-3-14(4-2-13)29-18(11-19(30)27-17-7-10-25-28-17)26-16-12-24-21-15(20(16)29)6-9-23-21/h6-7,9-10,12-14H,1-5,11H2,(H,23,24)(H2,25,27,28,30) RYRVJHUCQBRPSP-UHFFFAOYSA-N 505117 US11066406, Ex. 11 Tyrosine-protein kinase JAK3 [512-1124] 30.3 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505117&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611570 459090340 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 1058033 OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1 InChI=1S/C22H26N6O2/c23-9-5-14-1-3-15(4-2-14)28-18(11-19(29)26-13-22(30)7-8-22)27-17-12-25-21-16(20(17)28)6-10-24-21/h6,10,12,14-15,30H,1-5,7-8,11,13H2,(H,24,25)(H,26,29) PAZQNOKEWKWFNF-UHFFFAOYSA-N 505118 US11066406, Ex. 12 Tyrosine-protein kinase JAK3 [512-1124] 101 US Patent 10.7270/Q2571G4J aid1805680 US11066406 Fernandes, P; Krawczuk, PJ; Tichenor, MS Janssen Pharmaceutica NV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=505118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=769&target=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=505118&enzyme=Tyrosine-protein+kinase+JAK3+%5B512-1124%5D&column=ki&startPg=0&Increment=50&submit=Search 134611598 459090341 1 TFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 3PJC,6LZG,6M17,6W41,6X79,6XC2,6XC3,6XC4,6XC7,6XDG,6XE1,6XR8,6XRA,6YLA,6YM0,6YOR,6YZ5,6Z2M,6ZDG,6ZER,6ZFO,6ZOW,6ZP5,6ZP7,7BWJ,7C2L,7C3N,7C8D,7C8V,7C8W,7CAH,7CAN,7JMO,7JMP Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2